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https://www.readbyqxmd.com/read/29911437/synthesis-of-halogenated-azo-aspirin-analogues-from-natural-product-derivatives-as-the-potential-antibacterial-agents
#1
Zainab Ngaini, Nur Arif Mortadza
Chemical modification of medicines from natural product-based molecules has become of interest in recent years. In this study, a series of halogenated azo derivatives 1a-d were synthesised via coupling reaction, followed by Steglich esterification with aspirin (a natural product derivative) to form azo derivatives 2a-d. While, halogenated azo-aspirin 3a-d were synthesised via direct coupling reaction of aspirin and diazonium salt. Bacteriostatic activity was demonstrated against E. coli and S. aureus via turbidimetric kinetic method...
June 17, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29911299/overview-on-radiation-and-tissue-banking-in-latin-america
#2
Eulogia Kairiyama, Maria Esther Martínez Pardo, Eddy Sánchez Noda, Isabel Otero
The International Atomic Energy Agency (IAEA) played an important role in the establishment of new tissue banks and the improvement of already existing ones in Latin America. The Agency strongly supported, through regional, interregional and national technical cooperation projects, providing equipment, expert missions and training for the production and application of human tissues for transplantation. From 1999 to 2005 five regional courses were given in Buenos Aires under the modality of 1-year distance learning training courses and 1-week face to face courses...
June 18, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29911269/exploring-the-lead-compounds-for-zika-virus-ns2b-ns3-protein-an-e-pharmacophore-based-approach
#3
K Rohini, Pratika Agarwal, B Preethi, V Shanthi, K Ramanathan
The rapid spread of the Zika virus and its association with the abnormal brain development constitute a global health emergency. With a continuing spread of the mosquito vector, the exposure is expected to accelerate in the coming years. Despite number of efforts, there is still no proper vaccine or medicine to combat this virus. Of note, the NS2B-NS3 protein is proven to be the potential target for the Zika virus therapeutics. Hence, e-pharmacophore-based drug design strategy was employed to identify potent inhibitors of NS2B-NS3 protein from ASINEX database consisting of 467,802 molecules...
June 18, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29910741/physiology-and-pathophysiology-in-ultra-marathon-running
#4
REVIEW
Beat Knechtle, Pantelis T Nikolaidis
In this overview, we summarize the findings of the literature with regards to physiology and pathophysiology of ultra-marathon running. The number of ultra-marathon races and the number of official finishers considerably increased in the last decades especially due to the increased number of female and age-group runners. A typical ultra-marathoner is male, married, well-educated, and ~45 years old. Female ultra-marathoners account for ~20% of the total number of finishers. Ultra-marathoners are older and have a larger weekly training volume, but run more slowly during training compared to marathoners...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29908572/medicinal-plants-with-traditional-use-ethnobotany-in-the-indian-subcontinent
#5
Reena Rupani, Afton Chavez
Traditional medicine uses cultural knowledge and practices to promote health maintenance as well as diagnose and treat disease. In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported. We review the current understanding and research behind traditional therapies prevalent in the Indian subcontinent, including mind-body and energy-based healing, botanical medicine, and herbal remedies. Topics covered include Ayurveda, yoga, naturopathy, Unani, Siddha, Sowa-Rigpa, homeopathy, and medicinal plants such as neem, guggul, tulsi, amla, and turmeric...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29903607/improvement-of-physical-activity-in-chronic-obstructive-pulmonary-disease-by-pulmonary-rehabilitation-and-pharmacological-treatment
#6
REVIEW
Takanobu Shioya, Susumu Sato, Masahiro Iwakura, Hitomi Takahashi, Yoshino Terui, Sachiko Uemura, Masahiro Satake
Physical activity (PA) is defined as bodily movement produced by skeletal muscles with energy expenditure beyond resting levels. PA is closely related to reduced morbidity and mortality in chronic obstructive pulmonary disease (COPD). Self-report questionnaires are often subject to recall bias, correlating poorly with objectively qualified PA, and do not provide an accurate estimate of free-living energy expenditure. PA may be objectively evaluated by newly developed tri-axial accelerometers by quantifying steps or body movements over a period of time...
June 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29902041/it-hurts-to-move-on-a-family-s-experience-with-chronic-pain-grief-and-healing
#7
Grace S Kao
This article describes a family that had to deal with grief from losing a family member. They sought help for 13-yr-old Katie's prolonged pain following a sprain. The family's unresolved grief over their second child's passing continued to emerge, peeping through the small talk, the wry smiles, the daily efforts to move and do, despite physical pain. As the demands of Katie's rehabilitation stripped away reserves of politeness and energy, the family's emotional pain became more fully uncovered.The author describes the 6-week course of physical and occupational therapies, pain medicine management, and individual and family behavioral health support...
June 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29895364/influence-of-boric-acid-on-energy-metabolism-and-stress-tolerance-of-candida-albicans
#8
Martin Schmidt, Dominic Tran-Nguyen, Patrick Chizek
Boron presents at physiological pH in the form of boric acid (BA), a molecule that has both positive and negative effects on biological processes. In medicine, BA is used as a topical treatment for vaginal yeast infections by Candida species because of its well-documented but poorly understood effect on inhibition of growth in general and of invasive, hyphal growth in particular. The present study examines the influence of BA on carbohydrate energy metabolism of this common human pathogen. Starting from previous findings about an inhibition of key NAD-dependent enzymes by BA in vitro, we confirmed that such an inhibition occurs in permeabilized C...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29893715/measurement-of-gadolinium-retention-current-status-and-review-from-an-applied-radiation-physics-perspective
#9
James L Gräfe, Fiona E McNeill
OBJECTIVE: This article briefly reviews the main measurement techniques for the non-invasive detection of residual gadolinium (Gd) in those exposed to gadolinium based contrast agents (GBCAs). Approach and Main Results: The current status of in vivo Gd measurement is discussed and is put into the context of concerns within the radiology community. The main techniques are based on applied atomic/nuclear medicine utilizing the characteristic atomic and nuclear spectroscopic signature of Gd...
June 12, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29893333/validation-of-gate-for-bone-and-bone-marrow-with-calculation-specific-absorbed-fraction-for-photons
#10
Seydeh Zahra Ghaseminezhad, Alireza Sadremomtaz, Hossein Rajabi
Purpose: GATE/GEANT is a Monte Carlo code dedicated to nuclear medicine that allows calculation of the dose to organs (bone and bone marrow) of voxel phantoms. On the other hand, Medical Internal Radiation Dose (MIRD) is a well-developed system for estimation of the dose to human organs. In this study, results obtained from GATE/GEANT using leg of Snyder phantom is compared to published MIRD data. Materials and Methods: For this, the mathematical leg of Snyder phantom was discretized and converted to a digital phantom of 100 × 100 × 200 voxels...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29893068/wearables-in-medicine
#11
Ali K Yetisen, Juan Leonardo Martinez-Hurtado, Barış Ünal, Ali Khademhosseini, Haider Butt
Wearables as medical technologies are becoming an integral part of personal analytics, measuring physical status, recording physiological parameters, or informing schedule for medication. These continuously evolving technology platforms do not only promise to help people pursue a healthier life style, but also provide continuous medical data for actively tracking metabolic status, diagnosis, and treatment. Advances in the miniaturization of flexible electronics, electrochemical biosensors, microfluidics, and artificial intelligence algorithms have led to wearable devices that can generate real-time medical data within the Internet of things...
June 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29892438/preparation-of-a-low-cost-and-eco-friendly-superabsorbent-composite-based-on-wheat-bran-and-laterite-for-potential-application-in-chinese-herbal-medicine-growth
#12
Jiande Gao, Jin Liu, Hui Peng, Yaya Wang, Sha Cheng, Ziqiang Lei
A low-cost and eco-friendly superabsorbent composite is prepared through the free-radical graft co-polymerization of wheat bran (WB), acrylic acid (AA) and laterite (LA) in an aqueous solution. Elemental map, scanning electron microscopy and Fourier transform infrared spectra revealed that the LA evenly distributed in the superabsorbent composite and wheat bran-g-poly(acrylic acid)/laterite (WB-g-PAA/LA) formed successfully. Thermogravimetric analysis confirmed that the WB-g-PAA/LA had high thermal stability...
May 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29889160/extension-of-the-international-atomic-energy-agency-phantom-study-in-image-quantification-results-of-multicentre-evaluation-in-croatia
#13
Darko Grošev, Marin Gregov, Miroslava Radić Wolfl, Branislav Krstonošić, Dea Dundara Debeljuh
To make quantitative methods of nuclear medicine more available, four centres in Croatia participated in the national intercomparison study, following the materials and methods used in the previous international study organized by the International Atomic Energy Agency (IAEA). The study task was to calculate the activities of four Ba sources (T1/2=10.54 years; Eγ=356 keV) using planar and single-photon emission computed tomography (SPECT) or SPECT/CT acquisitions of the sources inside a water-filled cylindrical phantom...
June 7, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29888960/gene-expression-profiling-of-breast-cancer-cell-lines-treated-with-proton-and-electron-radiations
#14
Valentina Bravatà, Luigi Minafra, Francesco Paolo Cammarata, Pietro Pisciotta, Debora Lamia, Valentina Marchese, Lorenzo Manti, Giuseppe Ap Cirrone, Maria Carla Gilardi, Giacomo Cuttone, Giusi Irma Forte, Giorgio Russo
OBJECTIVE: Technological advances in radiation therapy are evolving with the use of hadrons, such as protons, indicated for tumors where conventional radiotherapy does not give significant advantages or for tumors located in sensitive regions, which need the maximum of dose-saving of the surrounding healthy tissues. The genomic response to conventional and non conventional Linear Energy Transfer exposure is a poor investigated topic and became an issue of radiobiological interest. The aim of this work was to analyze and compare molecular responses in term of gene expression profiles, induced by electron and proton irradiation in breast cancer cell lines...
June 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29884689/guidelines-for-quality-control-testing-of-molecular-breast-imaging-systems
#15
Sara M Nardinger, Thuy D Tran, Tiffinee Swanson, Lacey Ellingson, Courtney Solberg, Michael K O'Connor, Carrie B Hruska
Molecular breast imaging (MBI) is a nuclear medicine test that uses dedicated gamma cameras designed for imaging of the breast. Despite growing adoption of MBI, there is currently a lack of guidance on appropriate quality control procedures for MBI systems. Tests designed for conventional gamma cameras either do not apply or must be modified for dedicated detectors. Our objective was to provide practical guidance for physics testing of MBI systems by adapting existing quality control procedures for conventional systems...
June 8, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29884374/stabilization-of-bovine-lactoperoxidase-in-the-presence-of-ectoine
#16
Marziyeh Borjian Boroujeni, Hashem Nayeri
Lactoperoxidase (LPO) is a heme peroxidase with various applications in industry and medicine. In this study, the effects of ectoine, as a compatible solute, on the structure, thermal stability, thermodynamic parameters, activity, and stability of LPO have been investigated. The results showed that the catalytic activity of LPO was improved by increasing ectoine concentration. The UV-visible absorption spectroscopy and FTIR spectra studies indicated that ectoine could bind to the LPO spontaneously. Moreover, ectoine increased the enzyme Tm and Gibbs free energy...
November 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29883944/gallic-acid-targets-acute-myeloid-leukemia-via-akt-mtor-dependent-mitochondrial-respiration-inhibition
#17
Ruixin Gu, Minqin Zhang, Hu Meng, Dandan Xu, Yonghua Xie
Gallic acid is one of the many phenolic acids that can be found in dietary substances and traditional medicine herbs. The anti-cancer activities of gallic acid have been shown in various cancers but its underlying molecular mechanisms are not well understood. In this study, we show Akt/mammalian target of rapamycin (mTOR)-dependent inhibition of mitochondrial respiration as a mechanism of gallic acid's action in acute myeloid leukemia (AML). Gallic acid significantly induces apoptosis of AML cell lines, primary mononuclear cells (MNC) and CD34 stem/progenitors isolated form AML patients via caspase-dependent pathway...
June 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29881457/genetic-tool-development-and-systemic-regulation-in-biosynthetic-technology
#18
REVIEW
Zhongxue Dai, Shangjie Zhang, Qiao Yang, Wenming Zhang, Xiujuan Qian, Weiliang Dong, Min Jiang, Fengxue Xin
With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical genetic engineering and metabolic engineering. It gives a wider perspective and a deeper level to perceive the nature of life via cell mechanism, regulatory networks, or biological evolution. Currently, synthetic biology has made great breakthrough in energy, chemical industry, and medicine industries, particularly in the programmable genetic control at multiple levels of regulation to perform designed goals...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29875658/integration-of-metabonomics-and-transcriptomics-reveals-the-therapeutic-effects-and-mechanisms-of-baoyuan-decoction-for-myocardial-ischemia
#19
Zhiyong Du, Zeliu Shu, Wei Lei, Chun Li, Kewu Zeng, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
Myocardial ischemia (MI) is an escalating public health care burden worldwide. Baoyuan decoction (BYD) is a traditional Chinese medicine formula with cardioprotective activity; however, its pharmacological characteristics and mechanisms are obscured. Herein, a multi-omics strategy via incorporating the metabonomics, transcriptomics, and pharmacodynamics was adopted to investigate the effects and molecular mechanisms of BYD for treating MI in a rat model of left anterior descending coronary artery (LADCA) ligation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29874910/proteogenomic-analyses-revealed-favorable-metabolism-pattern-alterations-in-rotifer-brachionus-plicatilis-fed-with-selenium-rich-chlorella
#20
Xian Sun, Yizhi Cui, Qing Wang, Shengquan Tang, Xin Cao, Hongtian Luo, Zhili He, Xiaonong Hu, Xiangping Nie, Yufeng Yang, Tong Wang
Organoselenium have garnered attention because of their potential to be used as ingredients in new anti-aging and antioxidation medicines and food. Rotifers are frequently used as a model organism for ageing research. In this study, we used Se-enriched Chlorella (Se-Chlorella), a novel organoselenium compound, to feed Brachionus plicatilis to establish a rotifer model with a prolonged lifespan. The results showed that the antioxidative effect in Se-enriched rotifer was associated with an increase in guaiacol peroxidase (GPX) and catalase (CAT)...
June 6, 2018: Journal of Agricultural and Food Chemistry
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