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https://www.readbyqxmd.com/read/29047041/a-profound-computational-study-to-prioritize-the-disease-causing-mutations-in-prps1-gene
#1
Ashish Kumar Agrahari, P Sneha, C George Priya Doss, R Siva, Hatem Zayed
Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited congenital neurological disorders, affecting approximately 1 in 2500 in the US. About 80 genes were found to be in association with CMT. The phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is an essential enzyme in the primary stage of de novo and salvage nucleotide synthesis. The mutations in the PRPS1 gene leads to X-linked Charcot-Marie-Tooth neuropathy type 5 (CMTX5), PRS super activity, Arts syndrome, X-linked deafness-1, breast cancer, and colorectal cancer...
October 18, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29046623/biocompatible-d-a-semiconducting-polymer-nanoparticle-with-light-harvesting-unit-for-highly-effective-photoacoustic-imaging-guided-photothermal-therapy
#2
Jinfeng Zhang, Caixia Yang, Rui Zhang, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Shih-Hao Peng, Xiaoyuan Chen, Gang Liu, Chain-Shu Hsu, Chun-Sing Lee
The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent...
April 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29046352/the-lignan-manassantin-is-a-potent-and-specific-inhibitor-of-mitochondrial-complex-i-and-bioenergetic-activity-in-mammals
#3
Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang
Dineolignans manassantin A and B from the plant Saururus cernuus are used in traditional medicine to manage a wide range of ailments such as edema, jaundice, and gonorrhea. Cell-based studies have identified several molecular target candidates of manassantin including NF-kappaB, MAPK, STAT3 and hypoxia-inducible factor 1 alpha (HIF-1alpha). It is unclear whether or how these structurally diverse proteins or pathways mediate any of the medical benefits of manassantin in vivo. Moreover, it has been recently reported that manassantin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial respiration in intact mammalian cells and live animals...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29041431/depth-resolved-snapshot-energy-dispersive-x-ray-diffraction-using-a-conical-shell-beam
#4
A J Dicken, J P O Evans, K D Rogers, D Prokopiou, S X Godber, M Wilson
We demonstrate a novel imaging architecture to collect range encoded diffraction patterns from overlapping samples in a single conical shell projection. The patterns were measured in the dark area encompassed by the beam via a centrally positioned aperture optically coupled to a pixelated energy-resolving detector. We show that a single exposure measurement of 0.3 mAs enables d-spacing values to be calculated. The axial positions of the samples were not required and the resultant measurements were robust in the presence of crystallographic textures...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29040931/a-combined-experimental-ir-raman-and-uv-vis-and-quantum-chemical-study-of-canadine
#5
Bhawani Datt Joshi, Anubha Srivastava, Poonam Tandon, Sudha Jain, A P Ayala
Plant based natural products cover a major sector of the medicinal field, as such focus on plant research has been increased all over the world. As an attempt to aid that research, we have performed structural and spectroscopic analysis of a natural product, an alkaloid: canadine. Both ab initio Hartree-Fock (HF) and density functional theory (DFT) employing B3LYP using 6-311++G(d,p) basis set were used for the calculations. The calculated vibrational frequencies were scaled and compared with the experimental infrared and Raman spectra...
October 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29025660/electrospun-carboxyl-multi-walled-carbon-nanotubes-grafted-polyhydroxybutyrate-composite-nanofibers-membrane-scaffolds-preparation-characterization-and-cytocompatibility
#6
Cai Zhijiang, Zhu Cong, Guo Jie, Zhang Qing, Zhao Kongyin
Electrospun polyhydroxybutyrate (PHB)/carboxyl multi-walled carbon nanotubes grafted polyhydroxybutyrate (CMWCNT-g-PHB) composite nanofibers scaffolds were fabricated by electrospinning technology. The grafted product CMWCNT-g-PHB was prepared by condensation reactions between the carboxyl groups of CMWCNT and hydroxyl groups of PHB molecules and characterized by FTIR, XRD, XPS, TG and TEM measurements. The surface morphology, hydrophilicity and tensile mechanical properties of the electrospun PHB/CMWCNT-g-PHB composite nanofibers membrane scaffolds were investigated...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29022335/a-paper-carbon-nanotube-based-wearable-pressure-sensor-for-physiological-signal-acquisition-and-soft-robotic-skin
#7
Zhaoyao Zhan, Rongzhou Lin, Van-Thai Tran, Jianing An, Yuefan Wei, Hejun Du, Tuan Tran, Wenqiang Lu
Wearable and flexible pressure sensor is essential to the realization of personalized medicine through continuously monitoring an individual's state of health and also the development of highly intelligent robot. A flexible, wearable pressure sensor is fabricated based on novel SWNT/tissue paper through a low-cost and scalable approach. The flexible, wearable sensor showed superior performance with concurrence of several merits, including high sensitivity for a broad pressure range and ultralow energy consumption level of (~10-6 W)...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29021821/utilization-of-traditional-complementary-and-alternative-medicine-and-mental-health-among-patients-with-chronic-diseases-in-primary-health-care-settings-in-cambodia
#8
Siyan Yi, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Tyler Fleming, Carinne Brody
BACKGROUND: Coping with chronic illnesses often involves major lifestyle changes that may lead to poor mental health. Furthermore, in order to treat the chronic conditions, many sufferers in Asia turn to traditional, complementary and alternative medicines (TCAM). This study explores prevalence of TCAM use and factors associated with anxiety and depressive symptoms among patients with chronic diseases in Cambodia. METHODS: In 2015, this cross-sectional study was conducted with outpatients receiving treatment and care for chronic diseases in two urban and two rural primary health centers...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29021704/the-effect-of-red-ginseng-and-ginseng-leaves-on-the-substance-and-energy-metabolism-in-hypothyroidism-rats
#9
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou
BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021568/the-brain-and-immune-system-prompt-energy-shortage-in-chronic-inflammation-and-ageing
#10
REVIEW
Rainer H Straub
Sequelae frequently seen in patients with chronic inflammatory diseases, such as fatigue, depressed mood, sleep alterations, loss of appetite, muscle wasting, cachectic obesity, bone loss and hypertension, can be the result of energy shortages caused by an overactive immune system. These sequelae can also be found in patients with chronic inflammatory diseases that are in remission and in ageing individuals, despite the immune system being less active in these situations. This Perspectives article proposes a new way of understanding situations of chronic inflammation (such as rheumatic diseases) and ageing based on the principles of evolutionary medicine, energy regulation and neuroendocrine-immune crosstalk...
October 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29019337/monte-carlo-simulation-of-beta-particle-induced-bremsstrahlung-doses
#11
Dusan Mrdja, Kristina Bikit, Istvan Bikit, Jaroslav Slivka, Sofija Forkapic, Jovana Knezevic
It is well known that the protection from external irradiation produced by beta emitters is simpler than the corresponding shielding of radioactive sources that emit gamma radiation. This is caused by relatively strong absorption (i.e. short range) of electrons in different materials. However, for strong beta sources specific attention should be devoted to the bremsstrahlung radiation induced in the source encapsulation (matrix), especially for emitters with relatively high beta-endpoint energy (1 MeV), that are frequently used in nuclear medicine...
October 11, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28994664/compton-camera-study-for-high-efficiency-spect-and-benchmark-with-anger-system
#12
Mattia Fontana, Denis Dauvergne, Jean Michel Letang, Jean-Luc Ley, Etienne Testa
Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection eciency and energy acceptance are limited and xed by the system's geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years...
October 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28994528/-research-progress-on-regulation-effect-of-panax-notoginseng-saponins-on-mitochondria
#13
REVIEW
Zi-Ping Yang, Yi-Min Bao
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins(PNS) have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflammation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabolism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28994295/thermodynamics-of-polypeptide-supramolecular-assembly-in-the-short-chain-limit
#14
Thomas O Mason, Thomas C T Michaels, Aviad Levin, Christopher M Dobson, Ehud Gazit, Tuomas P J Knowles, Alexander K Buell
The self-assembly of peptides into ordered supramolecular structures, such as fibrils and crystals, is of relevance in such diverse areas as molecular medicine and materials science. However, little information is available about the fundamental thermodynamic driving forces of these types of self-assembly processes. Here we investigate in detail the thermodynamics of assembly of diphenylalanine. This dipeptide forms the central motif of the Aβ polypeptides which are associated with Alzheimer's disease through their presence in amyloid plaques in the nervous systems of affected individuals...
October 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28987949/zingiberis-rhizoma-mediated-enhancement-of-the-pharmacological-effect-of-aconiti-lateralis-radix-praeparata-against-acute-heart-failure-and-the-underlying-biological-mechanisms
#15
Lu Zhang, Xiaohua Lu, Jiabo Wang, Pengyan Li, Haotian Li, Shizhang Wei, Xuelin Zhou, Kun Li, Lifu Wang, Ruilin Wang, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata (Fuzi), a type of Chinese materia medica, has been used to treat acute and chronic heart failure (HF) in traditional Chinese medicine and has been proven in numerous animal studies. It is also well-known that Zingiberis Rhizoma (Ganjiang) is ineffective in the treatment of HF, but it can enhance the anti-HF effect of Fuzi. However, the mechanism underlying this compatibility is still not well investigated. To investigate this mechanism, a model of acute heart failure (AHF) in SD rats induced by propafenone hydrochloride was established in this study...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28987512/genes-linking-mitochondrial-function-cognitive-impairment-and-depression-are-associated-with-endophenotypes-serving-precision-medicine
#16
Peter Petschner, Xenia Gonda, Daniel Baksa, Nora Eszlari, Michael Trivaks, Gabriella Juhasz, Gyorgy Bagdy
Mitochondria densely populate cells in central nervous system providing essential energy for neurons and influencing synaptic plasticity. Harm to these organelles can impair cognitive performance through damaged neurotransmission and altered Ca(2+) homeostasis. Impaired cognition could be one underlying factor which can characterize major depressive disorder, a huge burden for society marked by depressed mood and anhedonia. A growing body of evidence binds mitochondrial dysfunctions with the disease. Cognitive disturbances with different severity are also observable in several patients, suggesting that damage or inherited alterations of mitochondria may have an important role in depression...
October 5, 2017: Neuroscience
https://www.readbyqxmd.com/read/28986937/effects-of-chinese-herbal-medicine-and-cold-exposure-on-plasma-glucose-leucine-and-energy-metabolism-in-sheep
#17
X Liang, J Jin, X Bi, M Kamruzzaman, T Kudo, H Sano
An experiment was carried out to assess the feeding effect of Chinese herbal medicine on N balance, ruminal fermentation characteristics, kinetics of plasma glucose, leucine and energy metabolism in sheep kept at thermoneutral environment (23°C) or exposed to cold (2-4°C). Four sheep were subjected to either mixed hay (MH-diet) or hay supplemented with 2% of a traditional nourishing Chinese herbal medicine mixture (Astragalus root, Angelica root and Atractylodes rhizome; CHM-diet) over two 23-day periods using a crossover design...
October 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28985065/the-origin-of-chalcogen-bonding-interactions
#18
Dominic J Pascoe, Kenneth B Ling, Scott L Cockroft
Favorable molecular interactions between group 16 elements have been implicated in catalysis, biological processes, materi-als and medicinal chemistry. Such interactions have since become known as chalcogen bonds by analogy to hydrogen and halogen bonds. Although the prevalence and applications of chalcogen-bonding interactions continues to develop, debate still surrounds the energetic significance and physicochemical origins of this class of -hole interaction. Here, synthetic mo-lecular balances were used to perform a quantitative experimental investigation of chalcogen-bonding interactions...
October 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28983969/a-high-performance-gradient-insert-for-rapid-and-short-t2-imaging-at-full-duty-cycle
#19
Markus Weiger, Johan Overweg, Manuela Barbara Rösler, Romain Froidevaux, Franciszek Hennel, Bertram Jakob Wilm, Alexander Penn, Urs Sturzenegger, Wout Schuth, Menno Mathlener, Martino Borgo, Peter Börnert, Christoph Leussler, Roger Luechinger, Benjamin Emanuel Dietrich, Jonas Reber, David Otto Brunner, Thomas Schmid, Laetitia Vionnet, Klaas P Pruessmann
PURPOSE: The goal of this study was to devise a gradient system for MRI in humans that reconciles cutting-edge gradient strength with rapid switching and brings up the duty cycle to 100% at full continuous amplitude. Aiming to advance neuroimaging and short-T2 techniques, the hardware design focused on the head and the extremities as target anatomies. METHODS: A boundary element method with minimization of power dissipation and stored magnetic energy was used to design anatomy-targeted gradient coils with maximally relaxed geometry constraints...
October 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28981338/heart-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-4-of-5
#20
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
October 5, 2017: Journal of Dietary Supplements
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