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https://www.readbyqxmd.com/read/29210486/4d-printed-actuators-with-soft-robotic-functions
#1
María López-Valdeolivas, Danqing Liu, Dick Jan Broer, Carlos Sánchez-Somolinos
Soft matter elements undergoing programed, reversible shape change can contribute to fundamental advance in areas such as optics, medicine, microfluidics, and robotics. Crosslinked liquid crystalline polymers have demonstrated huge potential to implement soft responsive elements; however, the complexity and size of the actuators are limited by the current dominant thin-film geometry processing toolbox. Using 3D printing, stimuli-responsive liquid crystalline elastomeric structures are created here. The printing process prescribes a reversible shape-morphing behavior, offering a new paradigm for active polymer system preparation...
December 6, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29210265/characterizing-the-switching-transitions-of-an-adsorbed-peptide-by-mapping-the-potential-energy-surface
#2
James A Ross-Naylor, Milan Mijajlovic, Hu Zhang, Mark J Biggs
Peptide adsorption occurs across technology, medicine and nature. The functions of adsorbed peptides are related to their conformation. In the past, molecular simulation methods such as molecular dynamics have been used to determine key conformations of adsorbed peptides. However, the transitions between these conformations often occur too slowly to be modeled reliably by such methods. This means such transitions are less well understood. In the study reported here, discrete path sampling is used for the first time to study the potential energy surface of an adsorbed peptide (polyalanine) and the transition pathways between various stable adsorbed conformations that have been identified in prior work by two of the authors (Mijajlovic, M...
December 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29206288/absorbed-dose-kernel-and-self-shielding-calculations-for-a-novel-radiopaque-glass-microsphere-for-transarterial-radioembolization
#3
Cody Church, George Mawko, John Paul Archambault, Robert Lewandowski, David Liu, Sharon Kehoe, Daniel Boyd, Robert Abraham, Alasdair Syme
PURPOSE: Radiopaque microspheres may provide intraprocedural and postprocedural feedback during transarterial radioembolization (TARE). Furthermore, the potential to use higher-resolution x-ray imaging techniques as opposed to nuclear medicine imaging suggests that significant improvements in the accuracy and precision of radiation dosimetry calculations could be realized for this type of therapy. This study investigates the absorbed dose kernel for novel radiopaque microspheres including contributions of both short and long-lived contaminant radionuclides while concurrently quantifying the self-shielding of the glass network...
December 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/29204141/flos-lonicera-combined-with-metformin-ameliorates-hepatosteatosis-and-glucose-intolerance-in-association-with-gut-microbiota-modulation
#4
Na R Shin, Shambhunath Bose, Jing-Hua Wang, AbuZar Ansari, Soo-Kyoung Lim, Young-Won Chin, Han-Seok Choi, Hojun Kim
The gut microbiota is important in energy contribution, metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with chronic metabolic diseases like type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Metformin (MET) and Flos Lonicera (FL) are common treatments for metabolic diseases in Western and Oriental medicinal fields. We evaluated the effect of treatment with FL and MET in combination on hepatosteatosis, glucose tolerance, and gut microbial composition...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29200714/simultaneous-determination-of-ten-constituents-in-chaiqin-qingning-capsule-by-high-performance-liquid-chromatography-coupled-with-triple-quadrupole-mass-spectrometry
#5
Ting Yu Li, Xiao Kui Huo, Lu Zheng, Chao Wang, Hai Jian Cong, Ting Xiang, Lin Zhang, Bao Jing Zhang, Shan Shan Huang, Bin Wu, Xin Yu Li
Background: Chaiqin Qingning Capsule (CQQNC) was a prescription of Traditional Chinese Medicine with the effects of clearing away heat and removing toxin, harmonizing the exterior and interior, it was widely used in Asian, for example, China and Japan, different batches of the raws materials and different processing time may be the vital factor which raised a challenge to control the quality of the CQQNC. Experimental Methods: In this experiment, a high-performance liquid chromatography-mass spectrometry/MS (HPLC-MS/MS) method was developed to simultaneously determine ten bioactive components for the quality control of CQQNC...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199929/healing-a-sick-world-psychiatric-medicine-and-the-atomic-age
#6
Ran Zwigenberg
The onset of nuclear warfare in Hiroshima and Nagasaki had far-reaching implications for the world of medicine. The study of the A-bomb and its implications led to the launching of new fields and avenues of research, most notably in genetics and radiation studies. Far less understood and under-studied was the impact of nuclear research on psychiatric medicine. Psychological research, however, was a major focus of post-war military and civilian research into the bomb. This research and the perceived revolutionary impact of atomic energy and warfare on society, this paper argues, played an important role in the global development of post-war psychiatry...
January 2018: Medical History
https://www.readbyqxmd.com/read/29199262/impaired-bioenergetics-in-clinical-medicine-a-target-to-tackle
#7
Sergej M Ostojic
Mitochondrial energy deficit is considered a key element of different clinical pathologies - from inherited disorders of energy metabolism to drug-induced mitochondrial toxicity, to cardiometabolic and neurodegenerative diseases. However, clinical manifestations of impaired bioenergetics are not easy to recognize, with patient-reported features usually include non-pathognomonic fatigue and weakness, or exercise intolerance, while specific lab tests are missing. Although it is not clear whether poor energetics is a primary deficit or a secondary consequence of specific disorders, improving mitochondrial viability remains a challenging task in both experimental and clinical medicine...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29195555/feasibility-of-beta-particle-radioguided-surgery-for-a-variety-of-nuclear-medicine-radionuclides
#8
Carlo Mancini-Terracciano, Raffaella Donnarumma, Gaia Bencivenga, Valerio Bocci, Antonella Cartoni, Francesco Collamati, Ilaria Fratoddi, Alessandro Giordano, Luca Indovina, Daria Maccora, Michela Marafini, Riccardo Mirabelli, Silvio Morganti, Dante Rotili, Andrea Russomando, Teresa Scotognella, Elena Solfaroli Camillocci, Marco Toppi, Giacomo Traini, Iole Venditti, Riccardo Faccini
PURPOSE: Beta-particle radioguided tumor resection may potentially overcome the limitations of conventional gamma-ray guided surgery by eliminating, or at least minimizing, the confounding effect of counts contributed by activity in adjacent normal tissues. The current study evaluates the clinical feasibility of this approach for a variety of radionuclides. Nowadays, the only β- radioisotope suited to radioguided surgery is 90Y. Here, we study the β- probe prototype capability to different radionuclides chosen among those used in nuclear medicine...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29195356/a-new-instrument-of-vuv-laser-desorption-ionization-mass-spectrometry-imaging-with-micrometer-spatial-resolution-and-low-level-of-molecular-fragmentation
#9
Jia Wang, Feng Liu, Yuxiang Mo, Zhaoying Wang, Sichun Zhang, Xinrong Zhang
Mass spectrometry imaging (MSI) has important applications in material research, biology, and medicine. The MSI method based on UV laser desorption/ionization (UVLDI) can obtain images of intact samples, but has a high level of molecular fragmentation. In this work, we report a new MSI instrument that uses a VUV laser (125.3 nm) as a desorption/ionization source to exploit its advantages of high single photon energy and small focus size. The new instrument was tested by the mass spectra of Nile red and FGB (Fibrinogen beta chain) samples and mass spectrometric images of a fly brain section...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29193287/sensitivity-enhancement-for-detection-of-hyperpolarized-13-c-mri-probes-with-1-h-spin-coupling-introduced-by-enzymatic-transformation-in-vivo
#10
Cornelius von Morze, James Tropp, Albert P Chen, Irene Marco-Rius, Mark Van Criekinge, Timothy W Skloss, Daniele Mammoli, John Kurhanewicz, Daniel B Vigneron, Michael A Ohliger, Matthew E Merritt
PURPOSE: Although 1 H spin coupling is generally avoided in probes for hyperpolarized (HP) 13 C MRI, enzymatic transformations of biological interest can introduce large 13 C-1 H couplings in vivo. The purpose of this study was to develop and investigate the application of 1 H decoupling for enhancing the sensitivity for detection of affected HP 13 C metabolic products. METHODS: A standalone 1 H decoupler system and custom concentric 13 C/1 H paddle coil setup were integrated with a clinical 3T MRI scanner for in vivo 13 C MR studies using HP [2-13 C]dihydroxyacetone, a novel sensor of hepatic energy status...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29189148/identification-of-novel-ligands-for-therapeutic-lipopeptides-daptomycin-surfactin-and-polymyxin
#11
Satya Eswari Jujjavarapu, Swasti Dhagat, Vinay Kurrey
Due to increase in antibiotic-resistance among pathogens, there is a need for potent and safe drugs. An alternative to antibiotics is lipopeptides which are produced as a secondary metabolite by many microorganisms. They exhibit broad-spectrum activities against pathogens along with anti-cancer properties. Among various lipopeptides produced by microorganisms, daptomycin, surfactin, and polymyxin have gained popularity as medicines but their mechanism of action is not described properly. In silico drug design of these lipopeptides becomes a challenge due to their complex structures...
November 29, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29186778/comparative-analysis-of-the-complete-chloroplast-genome-of-four-known-ziziphus-species
#12
(no author information available yet)
Ziziphus Mill. (Rhamnaceae) is comprised of about 170 species that are mainly distributed in tropical to subtropical regions, with few in the temperate zone. Several Ziziphus fruit tree species are important energy, nutrient, and medicinal resources for human populations, particularly for those living in rural regions. To date, limited genomic information is available for this genus. Here, we assembled the complete chloroplast genomes of four best known Ziziphus species, i.e., Ziziphus jujuba, Ziziphus acidojujuba, Ziziphus mauritiana, and Ziziphus spina-christi, based on the Illumina Paired-end sequencing method...
November 24, 2017: Genes
https://www.readbyqxmd.com/read/29186646/-how-staff-perceives-head-nurses-leadership-a-qualitative-study
#13
Giuliana Morsiani, Annamaria Bagnasco, Gianluca Catania, Giuseppe Aleo, Milko Zanini, Loredana Sasso
BACKGROUND: The leadership style of the head nurses plays a crucial role in ensuring a work environment that fosters high quality nursing care. Their role involves a range of activities that constantly change, and is therefore difficult to describe. In fact, we do not have a fixed set of characteristics to define the 'ideal candidate'. AIM: To understand how staff defines the key leadership characteristics of the ideal head nurse in charge of a hospital ward. METHOD: Between April-July 2015, 27 nurses were selected from the departments of general medicine in five hospitals...
July 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29186342/linking-metabolic-disease-with-the-pgc-1%C3%AE-gly482ser-polymorphism
#14
Roxanne Vandenbeek, Naveen P Khan, Jennifer L Estall
Peroxisome proliferator-activated receptor (PPAR)-γ coactivator 1 (PGC-1α) is a highly conserved transcriptional coactivator enriched in metabolically active tissues including liver, adipose, pancreas and muscle. It plays a role in regulating whole body energy metabolism and its deregulation has been implicated in Type 2 diabetes (T2D). A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29184961/highly-sensitive-detection-of-hesperidin-using-aunps-rgo-modified-glassy-carbon-electrode
#15
Yang Gao, Xiufeng Wu, Hui Wang, Wenbo Lu, Mandong Guo
The highly sensitive and selective electrochemical sensor of hesperidin based on gold nanoparticles (AuNPs) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE) is reported. The AuNPs and rGO were uniformly introduced on the surface of the GCE via electrodeposition without any reducing agents and have been characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), X-ray photoelectron spectroscopy (XPS), FT-IR, and electrochemical methods. The AuNPs/rGO not only promoted the accumulation of hesperidin onto the GCE surface for quantitative analysis but also accelerated the electron transfer between hesperidin and the electrode substrates...
November 29, 2017: Analyst
https://www.readbyqxmd.com/read/29179091/facile-approach-to-synthesize-highly-fluorescent-multicolor-emissive-carbon-dots-via-surface-functionalization-for-cellular-imaging
#16
Aniruddha Kundu, Jungpyo Lee, Byeongho Park, Chaiti Ray, K Vijaya Sankar, Wook Sung Kim, Soo Hyun Lee, Il-Joo Cho, Seong Chan Jun
Luminescent nanomaterials are encouraging scaffolds for diverse applications such as chemical sensors and biosensors, imaging, drug delivery, diagnostics, catalysis, energy, photonics, medicine, and so on. Carbon dots (CDs) are a new class of luminescent carbonaceous nanomaterial that have appeared recently and reaped tremendous scientific interest. Herein, we have exploited a simple approach to prepare tuneable and highly fluorescent CDs via surface functionalization. The successful synthesis of CDs is manifested from several investigations like high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS)...
November 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29177682/density-functional-theory-study-of-structural-and-electronic-properties-of-trans-and-cis-structures-of-thiothixene-as-a-nano-drug
#17
Akram Noori Tahneh, Samaneh Bagheri Novir, Ebrahim Balali
The geometrical structure, electronic and optical properties, electronic absorption spectra, vibrational frequencies, natural charge distribution, MEP analysis and thermodynamic properties of the trans and cis structures of the drug thiothixene were investigated using density functional theory (DFT) and time-dependent DFT (TDDFT) methods with the B3LYP hybrid functional and 6-311 + G(d,p) basis set. The results of the calculations demonstrate that the cis structure of thiothixene has appropriate quantum properties that can act as an active medicine...
November 25, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29177426/the-neutrons-for-science-facility-at-spiral-2
#18
X Ledoux, M Aïche, M Avrigeanu, V Avrigeanu, E Balanzat, B Ban-d'Etat, G Ban, E Bauge, G Bélier, P Bém, C Borcea, T Caillaud, A Chatillon, S Czajkowski, P Dessagne, D Doré, U Fischer, M O Frégeau, J Grinyer, S Guillous, F Gunsing, C Gustavsson, G Henning, B Jacquot, K Jansson, B Jurado, M Kerveno, A Klix, O Landoas, F R Lecolley, J L Lecouey, M Majerle, N Marie, T Materna, J Mrázek, J Novák, S Oberstedt, A Oberstedt, S Panebianco, L Perrot, A J M Plompen, S Pomp, A V Prokofiev, J M Ramillon, F Farget, D Ridikas, B Rossé, O Serot, S P Simakov, E Šimecková, M Stanoiu, M Štefánik, J C Sublet, J Taïeb, D Tarrío, L Tassan-Got, I Thfoin, C Varignon
The neutrons for science (NFS) facility is a component of SPIRAL-2, the new superconducting linear accelerator built at GANIL in Caen (France). The proton and deuteron beams delivered by the accelerator will allow producing intense neutron fields in the 100 keV-40 MeV energy range. Continuous and quasi-mono-kinetic energy spectra, respectively, will be available at NFS, produced by the interaction of a deuteron beam on a thick Be converter and by the 7Li(p,n) reaction on thin converter. The pulsed neutron beam, with a flux up to two orders of magnitude higher than those of other existing time-of-flight facilities, will open new opportunities of experiments in fundamental research as well as in nuclear data measurements...
November 21, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29173516/use-of-complementary-and-alternative-medicine-in-inflammatory-bowel-disease-around-the-world
#19
REVIEW
Petros Zezos, Geoffrey C Nguyen
Use of complementary sand alternative medicine (CAM) is common among patients with inflammatory bowel disease (IBD). CAM can be broadly categorized as whole medical systems, mind-body interventions, biologically based therapies, manipulative and body-based methods, and energy therapies. Most do not use it to treat IBD specifically, and most take it as an adjunct to conventional therapy not in place of it. However, patients are frequently uncomfortable initiating a discussion of CAM with their physicians, which may impact adherence to conventional therapy...
December 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#20
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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