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https://www.readbyqxmd.com/read/29651245/antiseptic-activity-of-ethnomedicinal-xuebijing-revealed-by-the-metabolomics-analysis-using-uhplc-q-orbitrap-hrms
#1
Lihua Zuo, Lin Zhou, Tanye Xu, Zhuolun Li, Liwei Liu, Yingying Shi, Jian Kang, Guanmin Gao, Shuzhang Du, Zhi Sun, Xiaojian Zhang
Xuebijing (XBJ) injection is an ethnomedicinal formula that has been widely used in the therapy of sepsis in China. However, the underlying theraputic mechanisms remain uninvestigated. In this research, a metabolomic method based on UHPLC-Q-Orbitrap HRMS was applied to make a holistic evaluation of XBJ on septic rats which were induced by the classical cecal ligation and puncture (CLP) operation. The plasma metabolic changes were profiled and evaluated by multivariate analytical (MVA) methods. In the results, a total of 41 differential metabolites were identified between CLP-operated group and sham-operated group, which were mainly involved in amino acid metabolism and lipid metabolism...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29650317/monte-carlo-based-assessment-of-magic-magicaug-pagatug-and-pagataug-polymer-gel-dosimeters-for-ovaries-and-uterus-organ-dosimetry-in-brachytherapy-nuclear-medicine-and-tele-therapy
#2
Karim Adinehvand, Fereidoun Nowshiravan Rahatabad
BACKGROUND AND OBJECTIVES: Calculation of 3D dose distribution during radiotherapy and nuclear medicine helps us for better treatment of sensitive organs such as ovaries and uterus. In this research, we investigate two groups of normoxic dosimeters based on meta-acrylic acid (MAGIC and MAGICAUG) and polyacrylamide (PAGATUG and PAGATAUG) for brachytherapy, nuclear medicine and Tele-therapy in their sensitive and critical role as organ dosimeters. METHODS: These polymer gel dosimeters are compared with soft tissue while irradiated by different energy photons in therapeutic applications...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29642719/impact-of-pharmacist-physician-collaboration-on-osteoporosis-treatment-rates
#3
Brandi L Bowers, Amy M Drew, Christian Verry
BACKGROUND: The vast majority of women at high risk for osteoporotic fractures are not treated, despite known significant clinical and economic consequences of this prevalent condition. To date, this is the first study of this size and duration to examine the role of pharmacists in management of osteoporosis in a family medicine clinic. OBJECTIVE: To compare the initiation or continuation of prescription antifracture therapy in high-risk patients with collaborative pharmacist-physician to physician-only management; secondarily, to evaluate recommendation rates for antifracture therapy and calcium and vitamin D...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29630078/applications-of-zeolites-in-biotechnology-and-medicine-a-review
#4
REVIEW
Lucie Bacakova, Marta Vandrovcova, Ivana Kopova, Ivan Jirka
Zeolites are microporous tectosilicates of natural or synthetic origin, which have been extensively used in various technological applications, e.g. as catalysts and as molecular sieves, for separating and sorting various molecules, for water and air purification, including removal of radioactive contaminants, for harvesting waste heat and solar heat energy, for adsorption refrigeration, as detergents, etc. These applications of zeolites were typically related with their porous character, their high adsorption capacity, and their ion exchange properties...
April 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29626946/implementation-of-quality-systems-in-nuclear-medicine-why-it-matters-an-outcome-analysis-quality-management-audits-in-nuclear-medicine-part-iii
#5
REVIEW
Maurizio Dondi, Diana Paez, Leonel Torres, Mario Marengo, Angelika Bischof Delaloye, Kishor Solanki, Annare Van Zyl Ellmann, Enrique Estrada Lobato, Rodolfo Nunez Miller, Francesco Giammarile, Thomas Pascual
The International Atomic Energy Agency (IAEA) developed a comprehensive program-Quality Management Audits in Nuclear Medicine (QUANUM). This program covers all aspects of nuclear medicine practices including, but not limited to, clinical practice, management, operations, and services. The QUANUM program, which includes quality standards detailed in relevant checklists, aims at introducing a culture of comprehensive quality audit processes that are patient oriented, systematic, and outcome based. This paper will focus on the impact of the implementation of QUANUM on daily routine practices in audited centers...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29625706/pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#6
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit/risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
March 6, 2018: Thérapie
https://www.readbyqxmd.com/read/29625260/protective-effects-of-polygonum-multiflorum-on-ischemic-stroke-rat-model-analysed-by-1-h-nmr-metabolic-profiling
#7
Ming-Hui Li, Ling-Yu Ruan, Cheng Chen, Yue-Xiao Xing, Wei Hong, Rong-Hui Du, Jun-Song Wang
Stroke is the third most common cause of death in most industrialized countries. Polygonum multiflorum (He-Shou-Wu, HSW) is one of the traditional Chinese medicines with multiple pharmacological activities which is widely used in Chinese recipe. This study aims to explore the protective effect of HSW on ischemic stroke rat model and to elucidate the underlying mechanisms. The mortality rate, neurological deficit, cerebral infarct size, histopathology, immunohistochemistry, biochemical parameters, quantitative real-time polymerase chain reaction and western blotting were used to access the treatment effects of HSW on ischemic stroke...
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29624114/ultrastructural-analysis-of-human-umbilical-cord-derived-mscs-at-undifferentiated-stage-and-during-osteogenic-and-adipogenic-differentiation
#8
Serbay Ozkan, Basak Isildar, Mahmut Oncul, Zafer Baslar, Semih Kaleli, Meral Koyuturk
Mesenchymal stem cells (MSCs) are considered as an important tool for regenerative medicine and experimental treatments. Unveiling the ultrastructural changes during the differentiation of MSCs might help us to understand the nature of the process and to develop novel therapeutic approaches. For this purpose, human umbilical cord (hUC) was chosen as MSC source. In the first place, MSCs were isolated from sub-amniotic, intervascular and perivascular areas of hUC by enzymatic and tissue explant method to determine the most favorable region of hUC and technique for further processing...
April 6, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29623512/incorporating-promis-symptom-measures-into-primary-care-practice-a-randomized-clinical-trial
#9
Kurt Kroenke, Tasneem L Talib, Timothy E Stump, Jacob Kean, David A Haggstrom, Paige DeChant, Kittie R Lake, Madison Stout, Patrick O Monahan
BACKGROUND: Symptoms account for more than 400 million clinic visits annually in the USA. The SPADE symptoms (sleep, pain, anxiety, depression, and low energy/fatigue) are particularly prevalent and undertreated. OBJECTIVE: To assess the effectiveness of providing PROMIS (Patient-Reported Outcome Measure Information System) symptom scores to clinicians on symptom outcomes. DESIGN: Randomized clinical trial conducted from March 2015 through May 2016 in general internal medicine and family practice clinics in an academic healthcare system...
April 5, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29619546/clinical-application-of-photodynamic-medicine-technology-using-light-emitting-fluorescence-imaging-based-on-a-specialized-luminous-source
#10
REVIEW
Tsutomu Namikawa, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Michiya Kobayashi, Kazuhiro Hanazaki
The natural amino acid 5-aminolevulinic acid (ALA) is a protoporphyrin IX (PpIX) precursor and a new-generation photosensitive substance that accumulates specifically in cancer cells. When indocyanine green (ICG) is irradiated with near-infrared (NIR) light, it shifts to a higher energy state and emits infrared light with a longer wavelength than the irradiated NIR light. Photodynamic diagnosis (PDD) using ALA and ICG-based NIR fluorescence imaging has emerged as a new diagnostic technique. Specifically, in laparoscopic examinations for serosa-invading advanced gastric cancer, peritoneal metastases could be detected by ALA-PDD, but not by conventional visible-light imaging...
April 4, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29617642/the-science-and-translation-of-lactate-shuttle-theory
#11
REVIEW
George A Brooks
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Shuttling between producer and consumer cells fulfills at least three purposes for lactate: (1) a major energy source, (2) the major gluconeogenic precursor, and (3) a signaling molecule. "Lactate shuttle" (LS) concepts describe the roles of lactate in delivery of oxidative and gluconeogenic substrates as well as in cell signaling. In medicine, it has long been recognized that the elevation of blood lactate correlates with illness or injury severity...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29615415/exposure-of-zebra-mussels-to-extracorporeal-shock-waves-demonstrates-formation-of-new-mineralized-tissue-inside-and-outside-the-focus-zone
#12
Katharina Sternecker, Juergen Geist, Sebastian Beggel, Kristin Dietz-Laursonn, Matias de la Fuente, Hans-Georg Frank, John P Furia, Stefan Milz, Christoph Schmitz
The success rate of extracorporeal shock wave therapy (ESWT) for fracture nonunions in human medicine (i.e., radiographic union at six months after ESWT) is only approximately 75%. Detailed knowledge regarding the underlying mechanisms that induce bio-calcification after ESWT is limited. We analyzed the biological response within mineralized tissue of a new invertebrate model organism, the zebra mussel Dreissena polymorpha , after exposure with extracorporeal shock waves (ESWs). Mussels were exposed to ESWs with positive energy density of 0...
April 3, 2018: Biology Open
https://www.readbyqxmd.com/read/29610612/the-effectiveness-of-radial-extracorporeal-shock-wave-therapy-for-chronic-achilles-tendinopathy-a-case-report-with-18-months-follow-up
#13
Erieta Dimitrije Nikolikj-Dimitrova, Cvetanka Gjerakaroska-Savevska, Valentina Koevska, Biljana Mitrevska, Marija Gocevska, Maja Manoleva, Biljana Kalchovska-Ivanovska
BACKGROUND: Achilles tendinopathy (AT) is a pathological state resulting from repetitive loading or stress on the tendon. The article aims to evaluate the effects of the low - energy radial extracorporeal shockwave therapy (RESWT) in the treatment of the adult with chronic insertional Achilles tendinopathy (AT) after the unsuccessful conservative treatment, with 18 months follow - up evaluation. CASE REPORT: We report the case of a 55 years - old male suffering from severe right posterior heel pain for 4 months...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609928/complementary-and-alternative-medicine-utilisation-for-the-management-of-acute-respiratory-tract-infection-in-children-a-systematic-review
#14
REVIEW
S Lucas, M Leach, S Kumar
INTRODUCTION: As many as one in two children across the globe use complementary and alternative medicine (CAM) to manage a health condition. Despite the high prevalence of use, there is still limited information on the types of CAM used in children, particularly for the management of one of the most common childhood health complaints - acute respiratory tract infection (ARTI). This systematic review was undertaken to address this knowledge gap. METHODS: Eligible studies reporting the use of CAM in children with ARTI were identified using a targeted search of seven electronic databases and the grey literature...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29609927/complementary-and-alternative-medicine-for-rheumatic-diseases-a-systematic-review-of-randomized-controlled-trials
#15
REVIEW
Jie Kie Phang, Yu Heng Kwan, Hendra Goh, Victoria Ie Ching Tan, Julian Thumboo, Truls Østbye, Warren Fong
OBJECTIVES: To summarize all good quality randomized controlled trials (RCTs) using complementary and alternative medicine (CAM) interventions in patients with rheumatic diseases. METHODS: A systematic literature review guided by the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) was performed. We excluded non-English language articles and abstract-only publications. Due to the large number of RCTs identified, we only include "good quality" RCTs with Jadad score of five...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29609095/a-comparative-proteomic-characterization-and-nutritional-assessment-of-naturally-and-artificially-cultivated-cordyceps-sinensis
#16
Xu Zhang, Qun Liu, Wei Zhou, Ping Li, Raphael N Alolga, Zhenming Qian, Wenjia Li, Lian-Wen Qi, Xiaojian Yin
Cordyceps sinensis has gained increasing attention due to its nutritional and medicinal properties. Herein, we employed label-free quantitative mass spectrometry to explore the proteome differences between naturally- and artificially-cultivated C. sinensis. A total of 22,829 peptides with confidence ≥95%, corresponding to 2541 protein groups were identified from the caterpillar bodies/stromata of 12 naturally- and artificially-cultivated samples of C. sinensis. Among them, 341 proteins showed significant differences between the samples of natural and artificial cultivation...
March 30, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29609009/effects-of-dahuang-zhechong-pill-on-doxorubicin-resistant-smmc-7721-xenografts-in-mice
#17
Li Wu, Ke Xing Cao, Zi Hui Ni, Wei Dong Li, Zhi Peng Chen, Xiao Liu, Hai Bo Cheng
ETHNOPHARMACOLOGICAL RELEVANCE: Dahuang zhechong pill (DHZCP) is a famous traditional Chinese medicinal prescription from the "Synopsis of Prescriptions of the Golden Chamber (Jin Kui Yao Lue)", an ancient Chinese medical classic. DHZCP is commonly used for clinical treatment of liver cancer by promoting blood circulation to dissolve blood stasis and by removing pathogenic vegetations. DHZCP-based treatment has been derived from Traditional Chinese Medicine (TCM) and is officially recorded in the Chinese Pharmacopoeia...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29608116/modified-mixed-nanomicelles-with-collagen-peptides-enhanced-oral-absorption-of-cucurbitacin-b-preparation-and-evaluation
#18
Lan Tang, Lulu Fu, Zhuanfeng Zhu, Yan Yang, Boxuan Sun, Weiguang Shan, Zhenhai Zhang
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine. Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailability of Cucurbitacin B (CuB). The physicochemical property of micelles was characterized, which confirmed the successful modification of the nanomicelles. CPs-modified nanomicelles in vitro were found to significantly increase cellular uptake and transportation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29607594/management-of-the-female-athlete-triad
#19
Sayaka Nose-Ogura, Miyuki Harada, Osamu Hiraike, Yutaka Osuga, Tomoyuki Fujii
The female athlete triad (FAT) is defined by the American College of Sports Medicine (ACSM) as low energy availability (low EA), functional hypothalamic amenorrhoea and osteoporosis. In low EA, lutein dysfunction first develops, followed by anovulation and, subsequently, oligomenorrhea, leading to amenorrhea. Moreover, low estradiol concentrations due to amenorrhea decrease bone mineral density (BMD). In athletes with one of the factors of FAT, the risk of a stress fracture is 2.4-4.9 times higher and may increase the risk of fracture throughout the lifespan...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29606212/review-plant-g-quadruplex-g4-motifs-in-dna-and-rna-abundant-intriguing-sequences-of-unknown-function
#20
REVIEW
Brianna D Griffin, Hank W Bass
DNA sequences capable of forming G-quadruplex (G4) structures can be predicted and mapped in plant genomes using computerized pattern search programs. Non-telomeric G4 motifs have recently been found to number in the thousands across many plant species and enriched around gene promoters, prompting speculation that they may represent a newly uncovered and ubiquitous family of cis-acting elements. Comparative analysis shows that monocots exhibit five to ten times higher G4 motif density than eudicots, but the significance of this difference has not been determined...
April 2018: Plant Science: An International Journal of Experimental Plant Biology
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