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https://www.readbyqxmd.com/read/29778857/development-of-a-risk-score-based-on-aortic-calcification-to-predict-1-year-mortality-after-transcatheter-aortic-valve-replacement
#1
Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Géraud Souteyrand, Marion Dupré, Marco Spaziano, Marc Bonnet, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre-Yves Courand, Lucie Cassagnes, Eduardo E Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui
OBJECTIVES: The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. BACKGROUND: A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. METHODS: The C4 CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29777507/rankl-expression-is-increased-in-circulating-mononuclear-cells-of-patients-with-calcific-aortic-stenosis
#2
Marcello Rattazzi, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Massimo Puato, Mario Plebani, Martina Zaninotto, Davide Condotta, Giacomo Zoppellaro, Leopoldo Pagliani, Giuseppe Tarantini, Sabino Iliceto, Elisa Covolo, Giuseppe Faggian, Francesco Onorati, Mikhail Dodonov, Alessandro Daniotti, Paola Pantano, Zoran Olivari, Giovanni Benfari, Paolo Pauletto
We aimed to investigate whether the expression of the OPG/RANK/RANKL triad in peripheral blood mononuclear cells (PBMC) and circulating levels of markers of ectopic mineralization (OPG, FGF-23, PPi) are modified in patients with calcific aortic valve disease (CAVD). We found that patients affected by CAVD (n = 50) had significantly higher circulating levels of OPG as compared to control individuals (p = 0.003). No differences between the two groups were found in FGF-23 and PPi levels. RANKL expression was higher in the PBMC from CAVD patients (p = 0...
May 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29773445/transcatheter-aortic-valve-insertion-in-patients-with-hostile-ascending-aorta-calcification
#3
Akio Nakasu, Kevin L Greason, Vuyisile T Nkomo, Mackram F Eleid, Alberto Pochettino, Katherine S King, Gurpreet S Sandhu, Eric E Williamson, David R Holmes
OBJECTIVE: Calcification of the ascending aorta complicates aortic valve replacement. Transcatheter aortic valve replacement is an alternative procedure in this situation, but it requires manipulation through the hostile area in the ascending aorta. We reviewed our transcatheter aortic valve insertion experience to better understand the surgical mortality risk of valve insertion in patients with extensive calcification of the ascending aorta. METHODS: We retrospectively reviewed the records of 665 consecutive patients who received transcatheter aortic valve insertion from November 2008 through December 2015...
April 7, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29762932/pulmonary-hypertension-as-a-possible-cause-of-paradoxical-low-flow-low-gradient-aortic-stenosis
#4
Yuta Watanabe, Haruhiko Higashi, Katsuji Inoue, Jun Aono, Takafumi Okura, Jitsuo Higaki, Shuntaro Ikeda
Paradoxical low-flow, low-gradient aortic stenosis (LFLG AS) is recognized as a subtype of aortic stenosis. A small left ventricular (LV) cavity with marked LV concentric remodeling leads to a reduced stroke volume in this condition. The case is reported of a paradoxical LFLG AS patient who was undergoing treatment for pulmonary hypertension (PH) and interstitial pneumonia associated with scleroderma. Echocardiography demonstrated enlargement of the right ventricle and a diminished LV cavity. Moreover, the aortic valve opening was restricted despite a preserved LV ejection fraction (61%)...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762922/redo-scoring-for-prediction-of-success-of-redo-percutaneous-balloon-mitral-valvuloplasty-in-patients-with-mitral-restenosis
#5
Ragab A Mahfouz, Waleed Elawady, Mohamed Goda, Tamer Moustafa
BACKGROUND: Echocardiographic predictors of redo-percutaneous balloon mitral valvuloplasty (redo-PBMV) have not been well studied, and indications are based mainly on Wilkins score. The study aim was to evaluate the immediate results of redo-PMBV and to introduce a simplified redo-score to predict the success of redo-PBMV. METHODS: Two cohorts of symptomatic patients (derivation group, n = 218; validation group, n = 100) who had undergone redo-PBMV at a mean of 8...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29755074/-structural-deterioration-of-a-bovine-pericardial-valve-in-a-tricuspid-position-14-years-postoperatively-report-of-a-case
#6
Kazunori Ota, Koyu Tanaka, Naoki Asano, Shigeyoshi Gon, Masahito Saito, Kazuho Niimi, Hiromichi Inoue, Motohiko Tamura, Yuji Matsumura, Toshihiro Ohata, Hirotsugu Fukuda, Hiroshi Takano
Although nonstructural dysfunction of a bioprosthesis caused by pannus formation or native valve attachment has been well described, structural valve deterioration( SVD) caused by calcification or tear of a bioprosthesis, especially a bovine pericardial valve, is very rare in the tricuspid position. We report a case of redo tricuspid valve surgery for SVD 14 years after tricuspid valve replacement( TVR) using a Carpentier-Edwards Perimount (CEP) pericardial valve. A 71-year-old woman was referred to our hospital because of exertional dyspnea and pre-syncope...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29754916/accuracy-of-device-landing-zone-calcium-volume-measurement-with-contrast-enhanced-multidetector-computed-tomography
#7
Won-Keun Kim, Matthias Renker, Andreas Rolf, Christoph Liebetrau, Arnaud Van Linden, Mani Arsalan, Mirko Doss, Julian Rieck, Maksymilian P Opolski, Helge Möllmann, Thomas Walther, Christian W Hamm
BACKGROUND: The extent of aortic valve calcification is an important determinant of procedural success in transcatheter aortic valve implantation (TAVI). We sought to validate device landing zone calcium volume (DLZ-CV) measurements on contrast-enhanced multidetector computed tomography (MDCT) with non-contrast-enhanced scans as reference. METHODS: We determined DLZ-CV in 141 patients undergoing transfemoral TAVI. Non-contrast-enhanced images were analyzed using a threshold of 130 HU as reference (DLZ-CV130 )...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29753455/effect-of-severe-bioprosthetic-valve-tissue-ingrowth-and-inflow-calcification-on-valve-in-valve-performance
#8
Hoda Hatoum, Jennifer Dollery, Scott M Lilly, Juan A Crestanello, Lakshmi Prasad Dasi
While in vivo studies clearly demonstrate that supra-annular Valve-in-Valve (ViV) implantation provides the highest probability for optimal post-ViV pressure gradients (PG), there is still no physical insight into explaining anomalies where some supra-annular ViV implantations yield high pressure gradients while some sub-annular implantations yield low pressure gradients. The aim of this study is to explain how severe tissue ingrowth and calcification (TIC) in a surgical aortic valve (SAV) can be one physical mechanism leading to anomalous ViV performance characteristic...
May 4, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29752279/a-comprehensive-study-of-calcific-aortic-stenosis-from-rabbit-to-human-samples
#9
L Mourino-Alvarez, M Baldan-Martin, T Sastre-Oliva, M Martin-Lorenzo, A S Maroto, N Corbacho-Alonso, R Rincon, T Martin-Rojas, L F Lopez-Almodovar, G Alvarez-Llamas, F Vivanco, L R Padial, F de la Cuesta, M G Barderas
The global incidence of calcific aortic stenosis (CAS) is increasing due, in part, to a growing elderly population, and poses a great challenge to public health because of the multiple comorbidities of these patients. Using a rabbit model of CAS, we sought to characterize protein alterations associated with calcified valve tissue that can be ultimately measured in plasma as non-invasive biomarkers of CAS.Aortic valves from healthy and mild stenotic rabbits were analyzed by two-dimensional difference gel electrophoresis, and selected reaction monitoring was used to directly measure the differentially expressed proteins in plasma from the same rabbits to corroborate their potential as diagnostic indicators, and also in plasma from human subjects, to examine their translatability to the clinical setting...
May 10, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29751516/engineering-a-3d-bioprinted-model-of-human-heart-valve-disease-using-nanoindentation-based-biomechanics
#10
Dewy C van der Valk, Casper F T van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V C Bouten, Simon C Body, David J Mooney, Joost P G Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and engineered a three-dimensional (3D)-bioprinted CAVD model that recapitulates leaflet layer biomechanics for the first time...
May 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29748594/reassessing-endothelial-to-mesenchymal-transition-in-cardiovascular-diseases
#11
REVIEW
Yan Li, Kathy O Lui, Bin Zhou
Endothelial cells and mesenchymal cells are two different cell types with distinct morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably from lineage-tracing studies, indicates that the two cell types convert into each other during cardiovascular development and pathogenesis. During heart development, endothelial cells transdifferentiate into mesenchymal cells in the endocardial cushion through endothelial-to-mesenchymal transition (EndoMT), a process that is critical for the formation of cardiac valves...
May 10, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29748157/interleukin-32-plays-an-essential-role-in-human-calcified-aortic-valve-cells
#12
Chung-Lin Tsai, Ying-Ming Chiu, Yi-Ju Lee, Chin-Tung Hsieh, Dong-Chen Shieh, Gregory J Tsay, Da-Tian Bau, Yi-Ying Wu
Interleukin-32 (IL-32) is an inflammatory cytokine produced mainly by T, natural killer, and epithelial cells. Previous studies on IL-32 have primarily investigated its proinflammatory properties. The IL-32 also has been described as an activator of the p38 mitogen-activated protein kinase (MAPK) and NF-κB, and induces several cytokines. In this study, we hypothesized that the inflammatory regulators NF-κB, MAP kinase, STAT1, and STAT3 are associated with the expression of the IL-32 protein in human calcified aortic valve cells...
March 1, 2018: European Cytokine Network
https://www.readbyqxmd.com/read/29743908/quantitative-estimation-of-aortic-valve-calcification-in-multislice-computed-tomography-in-predicting-the-development-of-paravalvular-leaks-following-transcatheter-aortic-valve-replacement
#13
Małgorzata Ryś, Tomasz Hryniewiecki, Ilona Michałowska, Patrycjusz Stokłosa, Monika Różewicz-Juraszek, Zbigniew Chmielak, Maciej Dąbrowski, Kryspin Mirota, Piotr Szymański
Introduction: Transcatheter aortic valve implantation (TAVI) improves prognosis in patients disqualified from surgical valve replacement. Calcifications of the aortic complex can lead to deformation of the prosthesis, resulting in paravalvular leaks (PVL). Aim: To evaluate the predictive value of quantitative estimation of volume/weight and geometric distribution of calcifications in multislice computed tomography, for the development of PVL. Material and methods: This was a retrospective, case-control study on patients with a CoreValve aortic prosthesis...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29735255/computed-tomography-predictors-of-mortality-stroke-and-conduction-disturbances-in-women-undergoing-tavr-a-sub-analysis-of-the-win-tavi-registry
#14
Marco Spaziano, Alaide Chieffo, Yusuke Watanabe, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefèvre, Anna Sonia Petronio, Patrizia Presbitero, Didier Tchetche, Alessandro Iadanza, Nicholas M Van Mieghem, Julinda Mehilli, Roxana Mehran, Marie-Claude Morice
BACKGROUND: Aortic valve calcification patterns were associated with short- and long-term outcomes in previous small observational datasets of patients undergoing transcatheter aortic valve implantation (TAVI). The specific impact of multi detector-row computed tomography (MDCT) findings on outcomes in women has not been reported. We sought to describe the associations between MDCT characteristics and clinical outcomes in a registry of 547 women undergoing TAVI. METHODS: WIN-TAVI is the first all-female registry to study the safety and effectiveness of TAVI in women (n = 1019)...
April 27, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29734266/noncoding-rnas-in-calcific-aortic-valve-disease-a-review-of-recent-studies
#15
Wen-Juan Ni, Ying-Zhong Wu, Dong-Hong Ma, Xiao-Min Leng
Calcific aortic valve disease (CAVD) is the most common heart valve disorder in human populations. Nevertheless, there are presently no effective means for its prevention and treatment. It is therefore critical to comprehensively define key mechanisms of the disease. A major focus of cardiovascular research has been characterization of how regulation of gene expression maintains healthy physiologic status of the component tissues of the system and how derangements of gene regulation may become pathological...
May 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29731112/degenerative-mitral-stenosis-from-pathophysiology-to-challenging-interventional-treatment
#16
REVIEW
Marko Banovic, Mark DaCosta
Mitral stenosis (MS) is characterized by obstruction of left ventricular inflow as a result of narrowing of the mitral valve orifice. Although its prevalence has declined over the last decade, especially in developed countries, it remains an important cause of morbidity and mortality.  The most often cause of MS worldwide is still postrheumatic mitral valve disease. However, in developed countries, degenerative or calcific changes cause MS in a siginificant proportion of patients. Although the range of treatment for mitral valve disease has grown over the years in parallel with transcatheter therapies for aortic valve disease, these improvements in mitral valve disease therapy have experienced slower development...
April 6, 2018: Current Problems in Cardiology
https://www.readbyqxmd.com/read/29726894/dna-methylation-of-a-plpp3-mir-transposon-based-enhancer-promotes-an-osteogenic-program-in-calcific-aortic-valve-disease
#17
Ghada Mkannez, Valérie Gagné-Ouellet, Mohamed Jalloul Nsaibia, Marie-Chloé Boulanger, Mickael Rosa, Deborah Argaud, Fayez Hadji, Nathalie Gaudreault, Gabrielle Rhéaume, Luigi Bouchard, Yohan Bossé, Patrick Mathieu
Aims: Calcific aortic valve disease (CAVD) is characterized by the osteogenic transition of valve interstitial cells (VICs). In CAVD, lysophosphatidic acid (LysoPA), a lipid mediator with potent osteogenic activity, is produced in the aortic valve (AV) and is degraded by membrane-associated phospholipid phosphatases (PLPPs). We thus hypothesized that a dysregulation of PLPPs could participate to the osteogenic reprograming of VICs during CAVD. Methods and Results: The expression of PLPPs was examined in human control and mineralized AVs and comprehensive analyses were performed to document the gene regulation and impact of PLPPs on the osteogenic transition of VICs...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29726546/the-role-of-standard-non-ecg-gated-chest-ct-in-cardiac-assessment-design-and-rationale-of-the-cardiac-pathologies-in-standard-chest-ct-capact-study
#18
Nienke G Eijsvoogel, Babs M F Hendriks, Hugo B Park, Sibel Altintas, Casper Mihl, Barbora Horehledova, Bastiaan L J H Kietselaer, Harry J G M Crijns, Joachim E Wildberger, Marco Das
Modern high-performance computed tomography (CT) scanners with improved scan acquisition times now allow for routine assessment of cardiac pathologies on chest CTs, which can result in numerous incidental cardiac findings. The CaPaCT study, an observer blinded, single-centre study, aims to assess the visibility, management and possible clinical impact of incidental cardiac pathologies that are now becoming visible on standard chest CTs. A total of 217 consecutive patients referred for a chest CT on a high-performance third-generation dual-source CT scanner will be included...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29726029/near-complete-aortic-mechanical-valve-dehiscence-due-to-endocarditis-reinfection
#19
Neal S Gerstein, Castigliano M Bhamidipati, Peter M Schulman
Prosthetic valve infective endocarditis (IE) is one of the most serious postimplantation complications. Prosthetic aortic valve IE constitutes 1%-6% of all prosthetic valve IE cases. We present a dramatic echocardiographic case of prosthetic aortic valve IE leading to near-complete valve dehiscence. Echocardiographic evidence of prosthetic aortic valve rocking motion is indicative of significant dehiscence. Aside from IE, other causes and risk factors for prosthetic aortic valve dehiscence include inflammatory and autoimmune vasculitides, concomitant ascending aorta aneurysm, and aortic root calcification...
May 3, 2018: Echocardiography
https://www.readbyqxmd.com/read/29721704/workup-and-management-of-patients-with-paradoxical-low-flow-low-gradient-aortic-stenosis
#20
REVIEW
Mohamed-Salah Annabi, Marine Clisson, Marie-Annick Clavel, Philippe Pibarot
About 60% of patients with paradoxical low-flow, low-gradient (PLF-LG) aortic stenosis (AS) have a severe disease that justifies aortic valve replacement (AVR). The first step in patients with symptomatic PLF AS should be to rule out measurement errors and treat hypertension. The second step is to distinguish pseudo-severe from true severe AS (TSAS). The third step is to select the optimal treatment modality at the right time. Regarding the second step, projected aortic valve area calculated using stress echocardiography is superior to traditional severity criteria (AVA < 1...
May 2, 2018: Current Treatment Options in Cardiovascular Medicine
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