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https://www.readbyqxmd.com/read/28913840/loss-of-regulatory-characteristics-in-cd4-cd25-hi-t-cells-induced-by-impaired-transforming-growth-factor-beta-secretion-in-pneumoconiosis
#1
Lu-Qin Bian, Ling Mao, Ying Bi, Shao-Wei Zhou, Zi-Dan Chen, Jun Wen, Jin Shi, Ling Wang
Pneumoconiosis is caused by the accumulation of airborne dust in the lung, which stimulates a progressive inflammatory response that ultimately results in lung fibrosis and respiratory failure. It is possible that regulatory cells in the immune system could function to suppress inflammation and possibly slow or reverse disease progression. However, results in this study suggest that in pneumoconiosis patients, the regulatory T cells (Tregs) and B cells are functionally impaired. First, we found that pneumoconiosis patients presented an upregulation of CD4(+) CD25(+) T cells compared to controls, whereas the CD4(+) CD25(+) and CD4(+) CD25(hi) T cells were enriched with Th1- and Th17-like cells but not Foxp3-expressing Treg cells and evidenced by significantly higher T-bet, interferon (IFN)-γ, and interleukin (IL)-17 expression but lower Foxp3 and transforming growth factor (TGF)-β expression...
September 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28912528/extracellular-vesicles-derived-from-t-regulatory-cells-suppress-t-cell-proliferation-and-prolong-allograft-survival
#2
Sistiana Aiello, Federica Rocchetta, Lorena Longaretti, Silvia Faravelli, Marta Todeschini, Linda Cassis, Francesca Pezzuto, Susanna Tomasoni, Nadia Azzollini, Marilena Mister, Caterina Mele, Sara Conti, Matteo Breno, Giuseppe Remuzzi, Marina Noris, Ariela Benigni
We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4(+)CD25(-) regulatory T cells (dnIKK2-Treg). These cells inhibited Tcell response in-vitro, without needing cell-to-cell contact, and induced kidney allograft survival prolongation in-vivo. Deep insight into the mechanisms behind dnIKK2-Treg-induced suppression of Tcell proliferation remained elusive. Here we document that dnIKK2-Treg release extracellular vesicles (EV) riched in exosomes, fully accounting for the cell-contact independent immunosuppressive activity of parent cells...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910968/efficiency-of-antibody-therapy-in-demyelinating-diseases
#3
Tetsuya Akaishi, Ichiro Nakashima
Monoclonal antibody therapy is a new treatment strategy for many types of diseases including cancers and autoimmune diseases, realizing a high efficacy and tolerability. In multiple sclerosis (MS) and neuromyelitis optica (NMO) spectrum disorders, several monoclonal antibodies have been suggested to decrease the incidence of clinical relapse and the disease activity. In MS, anti-α4 integrin (natalizumab), anti-CD52 (alemtuzumab), anti-CD25 (daclizumab) and anti-CD20 (ocrelizumab) have been shown to effectively reduce the relapses in randomized controlled trials and have been approved by the Food and Drug Administration...
July 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28910956/-modulation-of-umbilical-cord-blood-mesenchymal-stem-cells-on-treg-cells-in-the-patients-with-aplastic-anemia
#4
Y N Cao, F Zhou, N X Song, Y Fang, R Guan
Objective: To research the modulation of Umbilical cord blood mesenchymal stem cells on the number and function of Treg cells in the patients with aplastic anemia, as well as the expression of LFA-1 on Treg cells. Methods: A total of 20 newly diagnosed NSAA patients were collected from May 2015 to Jun 2016 in Department of Hematopathy, General Hospital of Jinan Military, and 10 healthy volunteers were recruited as controls. Separation of the patients and controls with peripheral blood mononuclear cells were divided into two groups, including PBMCs culture alone, PBMCs co-culture with UC-MSCs, application of flow cytometry detect respectively the proportion of the Treg cells and the expression of LFA-1 on Treg cells under different culture conditions...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28910895/-correlation-analysis-of-the-epstein-barr-virus-recruited-regulatory-t-cells-in-nasopharyngeal-carcinoma-of-immune-escape
#5
P Bi, J Wang, J Lu, X Liu, F Wang, Y F Luo, S D Peng, X P Li
Objective: To investigate the relation of Epstein-Barr virus (EBV)-induced immune escape to regulatory T cells(Treg) in nasopharyngeal carcinoma(NPC). Methods: We recruited 83 patients who were pathologically diagnozed as nasopharyngeal carcinoma and treated in Nanfang Hospital from January to September 2016. CD4(+) CD25(+) FOXP3(+) Treg in peripheral blood was examined by flow cytometry and the level of EBV DNA in the blood was detected by quantitative real-time polymerase chain reaction(qRT-PCR)in 83 patients and 51 healthy adults as control...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28910785/oral-tolerization-with-mycobacterial-heat-shock-protein-65-reduces-chronic-experimental-atherosclerosis-in-aged-mice
#6
Cecilia Wick, Elisabeth Onestingel, Egon Demetz, Hermann Dietrich, Georg Wick
BACKGROUND: Atherosclerosis is a chronic inflammatory disease of the artery wall where both innate and adaptive immunity play important roles. Modulation of the immune response against the stress protein antigen, heat shock protein (HSP) 60, by administration of mycobacterial HSP65 (mbHSP65) orally and/or nasally shows promising therapeutic results in young animals in the sense of less severe experimental atherosclerosis; however, the case of aged animals with already established atherosclerosis has so far never been investigated...
September 15, 2017: Gerontology
https://www.readbyqxmd.com/read/28904130/ccr5-dependent-homing-of-t-regulatory-cells-to-the-tumor-microenvironment-contributes-to-skin-squamous-cell-carcinoma-development
#7
Carine Ervolino de Oliveira, Thais Helena Gasparoto, Claudia Ramos Pinheiro, Nádia Ghinelli Amôr, Maria Renata Sales Nogueira, Ramon Kaneno, Gustavo Pompermaier Garlet, Vanessa Soares Lara, João Santana da Silva, Karen Angélica Cavassani, Ana Paula Campanelli
Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. Recent studies show that regulatory T cells (Tregs) have a critical role in the modulation of an anti- tumor immune response, and consequently the SCC development. Since the accumulation of Tregs at the tumor site is, in part, due to selective recruitment through CCR5 and CCR5-associated chemokines, we investigated the role of CCR5 in the SCC development. Our findings showed that CCR5-deficient mice (CCR5KO) were efficient in controlling papilloma's incidence when compared with wild-type mice...
September 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28903402/impact-of-chronic-methamphetamine-treatment-on-the-atherosclerosis-formation-in-apoe-mice-fed-a-high-cholesterol-diet
#8
Pengfei Zhu, Lun Li, Bo Gao, Mingjing Zhang, Yuting Wang, Ye Gu, Liqun Hu
BACKGROUND: We previously reported that methamphetamine could promote atherosclerosis (AS) in ApoE-/- mice fed normal chow. We herein observed the impact of methamphetamine on AS in ApoE-/- mice fed a high cholesterol diet and explored the potential mechanisms. RESULTS AND MATERIALS AND METHODS: Male ApoE-/- mice fed a high cholesterol diet were treated with saline (NS, n = 5) or methamphetamine [8 mg/kg/day (M8, n = 6) through intraperitoneal injection] for 24 weeks...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901888/effects-of-oral-lactobacillus-administration-on-antioxidant-activities-and-cd4-cd25-forkhead-box-p3-foxp3-t-cells-in-nzb-w-f1-mice
#9
Bor-Show Tzang, Chung-Hsien Liu, Kuo-Ching Hsu, Yi-Hsing Chen, Chih-Yang Huang, Tsai-Ching Hsu
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterised by a dysregulation of the immune system, which causes inflammation responses, excessive oxidative stress and a reduction in the number of cluster of differentiation (CD)4+CD25+forkhead box P3 (FoxP3)+ T cells. Supplementation with certain Lactobacillus strains has been suggested to be beneficial in the comprehensive treatment of SLE. However, little is known about the effect and mechanism of certain Lactobacillus strains on SLE...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28901186/recipient-adipose-derived-stem-cells-enhance-recipient-cell-engraftment-and-prolong-allotransplant-survival-in-a-miniature-swine-hind-limb-model
#10
Yur-Ren Kuo, Chien-Chang Chen, Yen-Chou Chen, Ching-Ming Chien
Donor mesenchymal stem cells (MSCs) could prolong vascularized composite allotransplantation (VCA) survival in our previous studies. However, recipient adipose tissue is easier to harvest than donor tissue for preconditioning modulation. Hence, this study investigated the efficacy of recipient autologous adipose-derived stem cells (rADSCs) for VCA survival. The heterotopic hind-limb transplantation from female donor to male recipient was performed in outbred miniature swine. Group I ( n = 6) was untreated controls...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28899815/blockage-of-regulatory-t-cells-augments-induction-of-protective-immune-responses-by-influenza-virus-like-particles-in-aged-mice
#11
Zhiyuan Wen, Xi Wang, Ke Dong, Huizhong Zhang, Zhigao Bu, Ling Ye, Chinglai Yang
Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated impairment in immune responses...
September 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28894978/hydrogen-rich-saline-ameliorates-allergic-rhinitis-by-reversing-the-imbalance-of-th1-th2-and-up-regulation-of-cd4-cd25-foxp3-regulatory-t-cells-interleukin-10-and-membrane-bound-transforming-growth-factor-%C3%AE-in-guinea-pigs
#12
Feifei Xu, Shaoqing Yu, Mali Qin, Yong Mao, Ling Jin, Na Che, Shuangxi Liu, Rongming Ge
It is well known that CD4+CD25+Foxp3+Treg cells play an important role in the development of allergic rhinitis (AR); the defect of cell numbers and functions contribute to AR. Hydrogen has been proven effective in alleviating symptoms of AR. We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich saline (HRS) on CD4+CD25+Foxp3+Treg cells in animals with AR and investigate the underlying anti-inflammatory mechanism...
September 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28893978/gut-bacteria-from-multiple-sclerosis-patients-modulate-human-t-cells-and-exacerbate-symptoms-in-mouse-models
#13
Egle Cekanaviciute, Bryan B Yoo, Tessel F Runia, Justine W Debelius, Sneha Singh, Charlotte A Nelson, Rachel Kanner, Yadira Bencosme, Yun Kyung Lee, Stephen L Hauser, Elizabeth Crabtree-Hartman, Ilana Katz Sand, Mar Gacias, Yungjiao Zhu, Patrizia Casaccia, Bruce A C Cree, Rob Knight, Sarkis K Mazmanian, Sergio E Baranzini
The gut microbiota regulates T cell functions throughout the body. We hypothesized that intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune disorder of the CNS and thus analyzed the microbiomes of 71 MS patients not undergoing treatment and 71 healthy controls. Although no major shifts in microbial community structure were found, we identified specific bacterial taxa that were significantly associated with MS. Akkermansia muciniphila and Acinetobacter calcoaceticus, both increased in MS patients, induced proinflammatory responses in human peripheral blood mononuclear cells and in monocolonized mice...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28892752/graphene-quantum-dots-suppress-proinflammatory-t-cell-responses-via-autophagy-dependent-induction-of-tolerogenic-dendritic-cells
#14
Sergej Tomić, Kristina Janjetović, Dušan Mihajlović, Marina Milenković, Tamara Kravić-Stevović, Zoran Marković, Biljana Todorović-Marković, Zdenko Spitalsky, Matej Micusik, Dragana Vučević, Miodrag Čolić, Vladimir Trajković
Graphene quantum dots (GQD) are atom-thick nanodimensional carbon sheets with excellent physico-chemical and biological properties, making them attractive for application in theranostics. However, their immunoregulatory properties are insufficiently investigated, especially in human primary immune cells. We found that non-toxic doses of GQD inhibit the production of proinflammatory and T helper (Th)1 cytokines, and augment the production of anti-inflammatory and Th2 cytokines by human peripheral blood mononuclear cells...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28892471/dynamic-regulation-of-t-follicular-regulatory-cell-responses-by-interleukin-2-during-influenza-infection
#15
Davide Botta, Michael J Fuller, Tatiana T Marquez-Lago, Holly Bachus, John E Bradley, Amy S Weinmann, Allan J Zajac, Troy D Randall, Frances E Lund, Beatriz León, André Ballesteros-Tato
Interleukin 2 (IL-2) promotes Foxp3(+) regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones...
September 11, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28891726/nk-cell-effector-functions-regulation-by-modulating-ntreg-cell-population-during-progressive-growth-of-dalton-s-lymphoma-in-mice
#16
Munendra Singh Tomar, Sanjay Kumar, Sanjay Kumar, Pramod Kumar Gautam, Rishi Kant Singh, Praveen Kumar Verma, Surya Pratap Singh, Arbind Acharya
Natural killer (NK) cells are large granular lymphocytes of the innate immune system and play a pivotal role against virus-infected cells, microbial pathogens, and tumor cells. NK cells secrete several cytokine,s but IFN-γ secreted by NK cells play a vital role in the activation of the innate and adaptive immune systems. But during any infection or tumor burden, functional activity of NK cells is downregulated significantly by nTreg cells. It is also found that during tumor progression, the number of nTreg cells increases as a result; it effectively suppresses the antitumor activity of NK cells...
September 11, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28890870/treg-th17-cell-balance-and-phytohaemagglutinin-activation-of-t-lymphocytes-in-peripheral-blood-of-systemic-sclerosis-patients
#17
Ekaterina Krasimirova, Tsvetelina Velikova, Ekaterina Ivanova-Todorova, Kalina Tumangelova-Yuzeir, Desislava Kalinova, Vladimira Boyadzhieva, Nikolay Stoilov, Tsvetelina Yoneva, Rasho Rashkov, Dobroslav Kyurkchiev
AIM: To investigate T-cell activation, the percentage of peripheral T regulatory cells (Tregs), Th17 cells and the circulating cytokine profile in systemic sclerosis (SSc). METHODS: We enrolled a total of 24 SSc patients and 16 healthy controls in the study and divided the patients as having diffuse cutaneous SSc (dcSSc, n = 13) or limited cutaneous SSc (lcSSc, n = 11). We performed a further subdivision of the patients regarding the stage of the disease - early, intermediate or late...
August 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28890720/porcine-b-cell-subset-responses-to-toll-like-receptor-ligands
#18
Roman Othmar Braun, Sylvie Python, Artur Summerfield
Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large collection of TLR ligands and demonstrates that the TLR2 ligand Pam3Cys-SK4 and the TLR7/8 ligands gardiquimod and resiquimod are particularly efficient at inducing proliferation, CD25 and CCR7. This activation was also determined in B-cell subpopulations including a CD21(+)IgM(+) subset, an IgG(+) subset and two putative B1-like subsets, defined as CD21(-)IgM(high)CD11R1(+)CD11c(+)CD14(+) and CD21(-)IgM(high) CD11R1(-)CD11c(+)CD14(-) B cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28890022/lymphoproliferative-responses-to-dendritic-cell-presentation-of-sensitizing-allergens-in-atopic-children-with-multiple-allergies
#19
Tim H Scott-Taylor, Stefan-Claudiu Axinia, Stephan Strobel
BACKGROUND: Peripheral blood mononuclear cells (PBMCs) proliferate inconsistently, rendering current lymphoproliferation assays unreliable in diagnosis. OBJECTIVE: To investigate the utility and nature of proliferation responses in allergy by comparison of the standard lymphoproliferation with a new dendritic cell (DC) stimulated assay. METHODS: Monocyte-derived DCs were pulsed with allergens and incubated with autologous T cells for 7 days...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28888053/mesenchymal-stem-cells-overexpressing-interleukin-35-propagate-immunosuppressive-effects-in-mice
#20
Hao Guo, Na Zhao, Haopeng Gao, Xianghui He
OBJECTIVE: To explore generation of interleukin (IL)-35-expressing mouse adipocyte-derived mesenchymal stem cells (Ad-MSCs) using lentiviral vector and their potential immunosuppressive effects in mice. METHODS: Ad-MSCs were isolated and cultured in vitro and transfected with a lentivirus vector for overexpression of the therapeutic murine IL-35 gene. IL-35 expression in transfected MSCs (IL-35-MSCs) was quantified by enzyme-linked immunosorbent assay (ELISA). The lymphocytes subsets after one-way mixed lymphocyte culture and in vivo intravenous transplantation were analyzed by flow cytometry to evaluate the immunosuppressive effects of IL-35-MSCs...
September 9, 2017: Scandinavian Journal of Immunology
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