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https://www.readbyqxmd.com/read/29599319/aberrant-expression-of-piwil1-and-piwil2-and-their-clinical-significance-in-ductal-breast-carcinoma
#1
Monika Litwin, Anna Szczepańska-Buda, Dagmara Michałowska, Jędrzej Grzegrzółka, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, Andrzej Wojnar, Piotr Dzięgiel, Wojciech Witkiewicz
BACKGROUND/AIM: P-Element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) are involved in epigenetic regulation of gene expression in germline cells. Aberrant expression of piRNA and PIWI proteins have been identified in various types of tumour cells. The aim of this study was to evaluate the expression profiles of PIWI-like protein-1, -2 (PIWIL1 and PIWIL2), their immunohistochemical (IHC) characteristics in ductal breast cancer, and determine their correlation with clinicopathological parameters of this type of cancer...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29424261/the-breast-tumor-microenvironment-role-in-cancer-development-progression-and-response-to-therapy
#2
Suruchi Mittal, Nicola J Brown, Ingunn Holen
Numerous clinical and pre-clinical studies have provided ample evidence supporting that the tumor microenvironment plays a significant role during breast cancer development, progression and in determining the therapeutic response. Areas covered: This review focuses on the evolving concept of the microenvironment as the critical participant in each step of the multi-stage process of malignant progression. Currently, only a small number of molecules form part of routine molecular diagnostics in breast caner, but microenvironment-derived biomarkers are potential additions to existing predictive and prognostic marker panels...
February 9, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29422613/cx26-drives-self-renewal-in-triple-negative-breast-cancer-via-interaction-with-nanog-and-focal-adhesion-kinase
#3
Praveena S Thiagarajan, Maksim Sinyuk, Soumya M Turaga, Erin E Mulkearns-Hubert, James S Hale, Vinay Rao, Abeba Demelash, Caner Saygin, Arnab China, Tyler J Alban, Masahiro Hitomi, Luke A Torre-Healy, Alvaro G Alvarado, Awad Jarrar, Andrew Wiechert, Valery Adorno-Cruz, Paul L Fox, Benjamin C Calhoun, Jun-Lin Guan, Huiping Liu, Ofer Reizes, Justin D Lathia
Tumors adapt their phenotypes during growth and in response to therapies through dynamic changes in cellular processes. Connexin proteins enable such dynamic changes during development, and their dysregulation leads to disease states. The gap junction communication channels formed by connexins have been reported to exhibit tumor-suppressive functions, including in triple-negative breast cancer (TNBC). However, we find that connexin 26 (Cx26) is elevated in self-renewing cancer stem cells (CSCs) and is necessary and sufficient for their maintenance...
February 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/28981408/multi-instance-multi-label-learning-for-multi-class-classification-of-whole-slide-breast-histopathology-images
#4
Caner Mercan, Selim Aksoy, Ezgi Mercan, Linda G Shapiro, Donald L Weaver, Joann G Elmore
Digital pathology has entered a new era with the availability of whole slide scanners that create the high-resolution images of full biopsy slides. Consequently, the uncertainty regarding the correspondence between the image areas and the diagnostic labels assigned by pathologists at the slide level, and the need for identifying regions that belong to multiple classes with different clinical significances have emerged as two new challenges. However, generalizability of the state-of-the-art algorithms, whose accuracies were reported on carefully selected regions of interest (ROIs) for the binary benign versus cancer classification, to these multi-class learning and localization problems is currently unknown...
January 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28530703/trpv4-plays-a-role-in-breast-cancer-cell-migration-via-ca-2-dependent-activation-of-akt-and-downregulation-of-e-cadherin-cell-cortex-protein
#5
W H Lee, L Y Choong, T H Jin, N N Mon, S Chong, C S Liew, T Putti, S Y Lu, C Harteneck, Y P Lim
TRPV4 belongs to the 'Transient Receptor Potential' (TRP) superfamily. It has been identified to profoundly affect a variety of physiological processes, including nociception, heat sensation and inflammation. Unlike other TRP superfamily channels, its role in cancers are unknown until recently when we reported TRPV4 to be required for cancer cell softness that may promote breast cancer cell extravasation and metastasis. Here, we elucidated the molecular mechanisms mediated by TRPV4 in the metastatic breast cancer cells...
May 22, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28327615/neoadjuvant-chemotherapy-creates-surgery-opportunities-for-inoperable-locally-advanced-breast-cancer
#6
Minghao Wang, Lingmi Hou, Maoshan Chen, Yan Zhou, Yueyang Liang, Shushu Wang, Jun Jiang, Yi Zhang
Neoadjuvant chemotherapy (NAC), the systematic chemotherapy given to patients with locally advanced and inoperable breast caner, has been proven to be of great clinical values. Many scientific reports confirmed NAC could effectively eliminate sub-clinical disseminated lesions of tumor, and improve long-term and disease-free survival rate of patients with locally advanced breast cancer (LABC); however, up to now, LABC is still a serious clinical issue given improved screening and early diagnosis. This study, with main focus on inoperable LABC, investigated the values of NAC in converting inoperable LABC into operable status and assessed the prognosis...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28121956/better-survival-in-pmrt-of-female-breast-cancer-patients-with-5-negative-lymph-nodes-a-population-based-study
#7
Haiyong Wang, Chenyue Zhang, Li Kong, Hui Zhu, Jinming Yu
Many studies have confirmed the role of postmastectomy radiotherapy (PMRT) for breast cancer patients with at least 4 lymph nodes invasion in the postoperative therapy. Recently, the number of negative lymph nodes (NLNs) has been increasingly paid attention to and recognized as a prognostic indicator in different kinds of caners. Therefore, it is very necessary to study the association between the number of NLNs and the prognosis of PMRT in breast cancer patients. In our study, we used Surveillance, Epidemiology, and End Results (SEER) population-based data and identified 16,686 breast cancer patients to explore their correlation...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28081335/comparison-of-wire-guided-localization-and-radio-guided-occult-lesionlocalization-in-preoperative-localization-of-nonpalpable-breast-lesions
#8
Nazım Barış Kanat, Murat Tuncel, Tamer Aksoy, Ayşegül Fırat, Figen Demirkazık, Demirali Onat, Meltem Çağlar Tuncalı, Biray Emine Caner
BACKGROUND/AIM: Breast lesions that are not palpable on physical examination but considered suspicious for malignancy on mammography or ultrasonography should be marked before surgery. Wire-guided localization (WGL) is the most frequently used method for preoperative marking of nonpalpable breast lesions (NPBLs). An alternative is marking by a radioactive agent (radio-guided occult lesion localization; ROLL). The present study aimed to compare WGL and ROLL for preoperative marking. MATERIALS AND METHODS: The study included 25 patients marked by ROLL and 11 patients marked by WGL...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27713130/increased-gene-expression-noise-in-human-cancers-is-correlated-with-low-p53-and-immune-activities-as-well-as-late-stage-cancer
#9
Rongfei Han, Guanqun Huang, Yejun Wang, Yafei Xu, Yueming Hu, Wenqi Jiang, Tianfu Wang, Tian Xiao, Duo Zheng
Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to unveil the mechanisms of gene expression noise control, but the changes of gene expression precision in pathologic conditions like cancers are unknown. Here we analyzed the transcriptomic data of human breast, liver, lung and colon cancers, and found that the expression noise of more than 74.9% genes was increased in cancer tissues as compared to adjacent normal tissues...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27017506/high-use-of-complementary-and-alternative-medicine-among-a-large-cohort-of-women-with-a-family-history-of-breast-cancer-the-sister-study
#10
COMPARATIVE STUDY
Heather Greenlee, Christine L Sardo Molmenti, Laura Falci, Ross Ulmer, Sandra Deming-Halverson, Lisa A DeRoo, Dale P Sandler
Use of complementary and alternative medicine (CAM) is high among U.S. women, yet information is limited on use among women at increased breast cancer risk. We analyzed CAM use among women with a family history of breast cancer. CAM use was analyzed among women enrolled 2003-2009 in the Sister Study cohort. Eligible women were aged 35-74, U.S. or Puerto Rican residents, no personal history of breast cancer, and had ≥1 sister with breast cancer. Baseline data on CAM use in the past year were available for 49,734 women...
April 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26824347/one-step-forward-two-steps-back-xeno-micrornas-reported-in-breast-milk-are-artifacts
#11
Caner Bağcı, Jens Allmer
BACKGROUND: MicroRNAs (miRNAs) are short RNA sequences that guide post-transcriptional regulation of gene expression via complementarity to their target mRNAs. Discovered only recently, miRNAs have drawn a lot of attention. Multiple protein complexes interact to first cleave a hairpin from nascent RNA, export it into the cytosol, trim its loop, and incorporate it into the RISC complex which is important for binding its target mRNA. This process works within one cell, but circulating miRNAs have been described suggesting a role in cell-cell communication...
2016: PloS One
https://www.readbyqxmd.com/read/26316442/an-unusual-presentation-of-46-xy-pure-gonadal-dysgenesis-spontaneous-breast-development-and-menstruation
#12
Gönül Çatlı, Caner Alparslan, P Şule Can, Sinem Akbay, Sefa Kelekçi, Tahir Atik, Berk Özyılmaz, Bumin N Dündar
46,XY pure gonadal dysgenesis (Swyer syndrome) is characterized by normal female genitalia at birth. It usually first becomes apparent in adolescence with delayed puberty and amenorrhea. Rarely, patients can present with spontaneous breast development and/or menstruation. A fifteen-year-old girl presented to our clinic with the complaint of primary amenorrhea. On physical examination, her external genitals were completely female. Breast development and pubic hair were compatible with Tanner stage V. Hormonal evaluation revealed a hypergonadotropic state despite a normal estrogen level...
June 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26170884/yoga-for-health-related-quality-of-life-in-adult-cancer-a-randomized-controlled-feasibility-study
#13
Marcy McCall, Melanie McDonald, Sally Thorne, Alison Ward, Carl Heneghan
An increase in patient-led uptake of complementary therapies in adult cancer has led to a need for more rigorous study of such interventions and their outcomes. This study therefore aimed to evaluate the feasibility and acceptability of a yoga intervention in men and women receiving conventional treatment for a cancer diagnosis. Prospective, mixed methods feasibility trial allocated participants to receive one of three yoga interventions over a four-week study period. Data collection was completed through online survey of QOL-CA/CS and customized surveys...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26078682/the-effect-of-feeding-with-spoon-and-bottle-on-the-time-of-switching-to-full-breastfeeding-and-sucking-success-in-preterm-babies
#14
Aynur Aytekin, Ebru Betül Albayrak, Sibel Küçükoğlu, İbrahim Caner
AIM: This research was conducted to determine the effect of the feeding methods of spoonfeed and feeding by bottle on the time of switching to full breastfeeding and sucking success. MATERIAL AND METHODS: The study was conducted between September 2013 and January 2014 at the primary level of the neonatal intensive care clinics in two hospitals found in the eastern region of Turkey in a comperative and descriptive fashion. The population was composed of preterm babies who received treatment and care in these clinics during the period when the study was conducted and who met the criteria of the investigators...
December 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/25993646/efficacy-and-safety-of-her2-targeted-agents-for-breast-cancer-with-her2-overexpression-a-network-meta-analysis
#15
Qiuyan Yu, Zhenli Zhu, Yan Liu, Jun Zhang, Ke Li
BACKGROUND: Clinical trials of human epidermal growth factor receptor 2 (HER2)-targeted agents added to standard treatment have been efficacious for HER2-positive (HER2+) advanced breast cancer. To our knowledge, no meta-analysis has evaluated HER2-targeted therapy including trastuzumab emtansine (T-DM1) and pertuzumab for HER2-positive breast caner and ranked the targeted treatments. We performed a network meta-analysis of both direct and indirect comparisons to evaluate the effect of adding HER2-targeted agents to standard treatment and examined side effects...
2015: PloS One
https://www.readbyqxmd.com/read/25725194/mir-491-5p-functions-as-a-tumor-suppressor-by-targeting-jmjd2b-in-er%C3%AE-positive-breast-cancer
#16
Zeng Hui, Chen Yiling, You Wenting, Huang XuQun, Zhou ChuanYi, Li Hui
The involvement of miR-491-5p in breast cancer development is unclear. This study showed that miR-491-5p is significantly downregulated in ERα-positive breast cancer tissues and cell lines and is generally hypermethylated in ERα-positive breast cancer. MiR-491-5p overexpression significantly suppressed estrogen signaling and estrogen-stimulated proliferation of breast cancer cells. Furthermore, the histone demethylase JMJD2B was identified as a direct target of miR-491-5p. The ectopic expression of JMJD2B abrogated the phenotypic changes induced by miR-491-5p in breast cancer cells...
March 24, 2015: FEBS Letters
https://www.readbyqxmd.com/read/25621841/the-evolution-of-checkpoint-blockade-as-a-cancer-therapy-what-s-here-what-s-next
#17
REVIEW
Daniel Sanghoon Shin, Antoni Ribas
Unleashing the immune system to fight cancer has become one of the main treatment modalities since the anti-CTLA-4 antibody, ipilimumab was approved for patients with advanced melanoma in 2011. Pembrolizumab and nivolumab, two anti-PD-1 antibodies recently approved for the treatment of patients with metastatic melanoma, are being actively investigated for the treatment of multiple caners including lung, breast, bladder and renal cancers along with other anti-PD-1/L1 antibodies. Early results of combining of anti-CTLA-4 antibody and anti-PD-1 antibody treatment for advanced melanoma patients are showing impressive response rates with manageable toxicity profiles...
April 2015: Current Opinion in Immunology
https://www.readbyqxmd.com/read/25542235/curcumin-reverses-cisplatin-resistance-in-cisplatin-resistant-lung-caner-cells-by-inhibiting-fa-brca-pathway
#18
Ping Chen, Jian Li, He-Guo Jiang, Ting Lan, Yong-Chang Chen
Cisplatin (DDP) is the most widely used chemotherapy agent for treatment of malignancies including lung cancer. However, the effectiveness of DDP is often weakened by acquired resistance of tumor cells. DDP kills cancer cells primarily by creating intrastrand and interstrand DNA cross-links, which block DNA replication. The Fanconi anemia (FA)/BRCA pathway is a DNA cross-link damage repair pathway, which regulates cellular resistance to DNA cross-link agents, such as DDP. Some study has shown that natural compound curcumin sensitize human ovarian and breast cancer cells to DDP...
May 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25412937/the-single-nucleotide-polymorphism-936-c-t-vegf-is-associated-with-human-epidermal-growth-factor-receptor-2-expression-in-moroccan-breast-cancer-women
#19
Jalila Rahoui, Yassir Sbitti, Nadia Touil, Abdelilah Laraqui, Azeddine Ibrahimi, Brahim Rhrab, Abderrahman Al Bouzidi, Driss Moussaoui Rahali, Mohamed Dehayni, Mohamed Ichou, Fatima Zaoui, Saad Mrani
The vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is involved in the development and progression of breast cancer (BC). The functional +936 C/T polymorphism of the VEGF-A gene has been implicated in BC susceptibility; however, published data are conflicting. In the current case-control study, we analyzed the association of the +936 C/T polymorphism with BC risk and tumor markers expression, human epidermal growth factor receptor 2 (HER2/neu) and caner antigen 15.3 (CA 15.3) in Moroccan women...
December 2014: Medical Oncology
https://www.readbyqxmd.com/read/24716117/the-in-vivo-therapeutic-effect-of-free-wanderer-powder-xi%C3%A4-o-y%C3%A3-o-s%C3%A7-n-xiaoyaosan-on-mice-with-4t1-cell-induced-breast-cancer-model
#20
Wen-Fang Chen, Li Xu, Chung-Him Yu, Chui-Kwan Ho, Ka Wu, Gina Cw Leung, Man-Sau Wong
In the present study, we investigated the therapeutic effect of a classical TCM formula, Free Wanderer Powder ( xiāo yáo sǎn), in a breast cancer mouse model induced with estrogen-insensitive breast cancer 4T1 cells. Ovariectomized Balb/c mice (6-8 weeks) or sham mice were injected into the fourth mammary fat pad with 4T1 cells in which tumors were palpable 7 days after injection. On the eighth day, the mice were divided into 4 groups and tubefed daily with vehicle, Free Wanderer Powder ( xiāo yáo sǎn) formula or tamoxifen for 28 days...
January 2012: Journal of Traditional and Complementary Medicine
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