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https://www.readbyqxmd.com/read/27713130/increased-gene-expression-noise-in-human-cancers-is-correlated-with-low-p53-and-immune-activities-as-well-as-late-stage-cancer
#1
Rongfei Han, Guanqun Huang, Yejun Wang, Yafei Xu, Yueming Hu, Wenqi Jiang, Tianfu Wang, Tian Xiao, Duo Zheng
Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to unveil the mechanisms of gene expression noise control, but the changes of gene expression precision in pathologic conditions like cancers are unknown. Here we analyzed the transcriptomic data of human breast, liver, lung and colon cancers, and found that the expression noise of more than 74.9% genes was increased in cancer tissues as compared to adjacent normal tissues...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27017506/high-use-of-complementary-and-alternative-medicine-among-a-large-cohort-of-women-with-a-family-history-of-breast-cancer-the-sister-study
#2
Heather Greenlee, Christine L Sardo Molmenti, Laura Falci, Ross Ulmer, Sandra Deming-Halverson, Lisa A DeRoo, Dale P Sandler
Use of complementary and alternative medicine (CAM) is high among U.S. women, yet information is limited on use among women at increased breast cancer risk. We analyzed CAM use among women with a family history of breast cancer. CAM use was analyzed among women enrolled 2003-2009 in the Sister Study cohort. Eligible women were aged 35-74, U.S. or Puerto Rican residents, no personal history of breast cancer, and had ≥1 sister with breast cancer. Baseline data on CAM use in the past year were available for 49,734 women...
April 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/26824347/one-step-forward-two-steps-back-xeno-micrornas-reported-in-breast-milk-are-artifacts
#3
Caner Bağcı, Jens Allmer
BACKGROUND: MicroRNAs (miRNAs) are short RNA sequences that guide post-transcriptional regulation of gene expression via complementarity to their target mRNAs. Discovered only recently, miRNAs have drawn a lot of attention. Multiple protein complexes interact to first cleave a hairpin from nascent RNA, export it into the cytosol, trim its loop, and incorporate it into the RISC complex which is important for binding its target mRNA. This process works within one cell, but circulating miRNAs have been described suggesting a role in cell-cell communication...
2016: PloS One
https://www.readbyqxmd.com/read/26316442/an-unusual-presentation-of-46-xy-pure-gonadal-dysgenesis-spontaneous-breast-development-and-menstruation
#4
Gönül Çatlı, Caner Alparslan, P Şule Can, Sinem Akbay, Sefa Kelekçi, Tahir Atik, Berk Özyılmaz, Bumin N Dündar
46,XY pure gonadal dysgenesis (Swyer syndrome) is characterized by normal female genitalia at birth. It usually first becomes apparent in adolescence with delayed puberty and amenorrhea. Rarely, patients can present with spontaneous breast development and/or menstruation. A fifteen-year-old girl presented to our clinic with the complaint of primary amenorrhea. On physical examination, her external genitals were completely female. Breast development and pubic hair were compatible with Tanner stage V. Hormonal evaluation revealed a hypergonadotropic state despite a normal estrogen level...
June 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26170884/yoga-for-health-related-quality-of-life-in-adult-cancer-a-randomized-controlled-feasibility-study
#5
Marcy McCall, Melanie McDonald, Sally Thorne, Alison Ward, Carl Heneghan
An increase in patient-led uptake of complementary therapies in adult cancer has led to a need for more rigorous study of such interventions and their outcomes. This study therefore aimed to evaluate the feasibility and acceptability of a yoga intervention in men and women receiving conventional treatment for a cancer diagnosis. Prospective, mixed methods feasibility trial allocated participants to receive one of three yoga interventions over a four-week study period. Data collection was completed through online survey of QOL-CA/CS and customized surveys...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26078682/the-effect-of-feeding-with-spoon-and-bottle-on-the-time-of-switching-to-full-breastfeeding-and-sucking-success-in-preterm-babies
#6
Aynur Aytekin, Ebru Betül Albayrak, Sibel Küçükoğlu, İbrahim Caner
AIM: This research was conducted to determine the effect of the feeding methods of spoonfeed and feeding by bottle on the time of switching to full breastfeeding and sucking success. MATERIAL AND METHODS: The study was conducted between September 2013 and January 2014 at the primary level of the neonatal intensive care clinics in two hospitals found in the eastern region of Turkey in a comperative and descriptive fashion. The population was composed of preterm babies who received treatment and care in these clinics during the period when the study was conducted and who met the criteria of the investigators...
December 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/25993646/efficacy-and-safety-of-her2-targeted-agents-for-breast-cancer-with-her2-overexpression-a-network-meta-analysis
#7
Qiuyan Yu, Zhenli Zhu, Yan Liu, Jun Zhang, Ke Li
BACKGROUND: Clinical trials of human epidermal growth factor receptor 2 (HER2)-targeted agents added to standard treatment have been efficacious for HER2-positive (HER2+) advanced breast cancer. To our knowledge, no meta-analysis has evaluated HER2-targeted therapy including trastuzumab emtansine (T-DM1) and pertuzumab for HER2-positive breast caner and ranked the targeted treatments. We performed a network meta-analysis of both direct and indirect comparisons to evaluate the effect of adding HER2-targeted agents to standard treatment and examined side effects...
2015: PloS One
https://www.readbyqxmd.com/read/25725194/mir-491-5p-functions-as-a-tumor-suppressor-by-targeting-jmjd2b-in-er%C3%AE-positive-breast-cancer
#8
Zeng Hui, Chen Yiling, You Wenting, Huang XuQun, Zhou ChuanYi, Li Hui
The involvement of miR-491-5p in breast cancer development is unclear. This study showed that miR-491-5p is significantly downregulated in ERα-positive breast cancer tissues and cell lines and is generally hypermethylated in ERα-positive breast cancer. MiR-491-5p overexpression significantly suppressed estrogen signaling and estrogen-stimulated proliferation of breast cancer cells. Furthermore, the histone demethylase JMJD2B was identified as a direct target of miR-491-5p. The ectopic expression of JMJD2B abrogated the phenotypic changes induced by miR-491-5p in breast cancer cells...
March 24, 2015: FEBS Letters
https://www.readbyqxmd.com/read/25621841/the-evolution-of-checkpoint-blockade-as-a-cancer-therapy-what-s-here-what-s-next
#9
REVIEW
Daniel Sanghoon Shin, Antoni Ribas
Unleashing the immune system to fight cancer has become one of the main treatment modalities since the anti-CTLA-4 antibody, ipilimumab was approved for patients with advanced melanoma in 2011. Pembrolizumab and nivolumab, two anti-PD-1 antibodies recently approved for the treatment of patients with metastatic melanoma, are being actively investigated for the treatment of multiple caners including lung, breast, bladder and renal cancers along with other anti-PD-1/L1 antibodies. Early results of combining of anti-CTLA-4 antibody and anti-PD-1 antibody treatment for advanced melanoma patients are showing impressive response rates with manageable toxicity profiles...
April 2015: Current Opinion in Immunology
https://www.readbyqxmd.com/read/25542235/curcumin-reverses-cisplatin-resistance-in-cisplatin-resistant-lung-caner-cells-by-inhibiting-fa-brca-pathway
#10
Ping Chen, Jian Li, He-Guo Jiang, Ting Lan, Yong-Chang Chen
Cisplatin (DDP) is the most widely used chemotherapy agent for treatment of malignancies including lung cancer. However, the effectiveness of DDP is often weakened by acquired resistance of tumor cells. DDP kills cancer cells primarily by creating intrastrand and interstrand DNA cross-links, which block DNA replication. The Fanconi anemia (FA)/BRCA pathway is a DNA cross-link damage repair pathway, which regulates cellular resistance to DNA cross-link agents, such as DDP. Some study has shown that natural compound curcumin sensitize human ovarian and breast cancer cells to DDP...
May 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25412937/the-single-nucleotide-polymorphism-936-c-t-vegf-is-associated-with-human-epidermal-growth-factor-receptor-2-expression-in-moroccan-breast-cancer-women
#11
Jalila Rahoui, Yassir Sbitti, Nadia Touil, Abdelilah Laraqui, Azeddine Ibrahimi, Brahim Rhrab, Abderrahman Al Bouzidi, Driss Moussaoui Rahali, Mohamed Dehayni, Mohamed Ichou, Fatima Zaoui, Saad Mrani
The vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is involved in the development and progression of breast cancer (BC). The functional +936 C/T polymorphism of the VEGF-A gene has been implicated in BC susceptibility; however, published data are conflicting. In the current case-control study, we analyzed the association of the +936 C/T polymorphism with BC risk and tumor markers expression, human epidermal growth factor receptor 2 (HER2/neu) and caner antigen 15.3 (CA 15.3) in Moroccan women...
December 2014: Medical Oncology
https://www.readbyqxmd.com/read/24716117/the-in-vivo-therapeutic-effect-of-free-wanderer-powder-xi%C3%A4-o-y%C3%A3-o-s%C3%A7-n-xiaoyaosan-on-mice-with-4t1-cell-induced-breast-cancer-model
#12
Wen-Fang Chen, Li Xu, Chung-Him Yu, Chui-Kwan Ho, Ka Wu, Gina Cw Leung, Man-Sau Wong
In the present study, we investigated the therapeutic effect of a classical TCM formula, Free Wanderer Powder ( xiāo yáo sǎn), in a breast cancer mouse model induced with estrogen-insensitive breast cancer 4T1 cells. Ovariectomized Balb/c mice (6-8 weeks) or sham mice were injected into the fourth mammary fat pad with 4T1 cells in which tumors were palpable 7 days after injection. On the eighth day, the mice were divided into 4 groups and tubefed daily with vehicle, Free Wanderer Powder ( xiāo yáo sǎn) formula or tamoxifen for 28 days...
January 2012: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/24551675/an-8-years-retrospective-study-of-breast-cancer-incidence-in-ilam-province-western-iran
#13
Yasemi M, Hafezi Ahmadi M R, Khajavikhan J, Peyman H, Asadollahi K H, Yasemi M R, Hemati K
INTRODUCTION: Breast cancer is the most common cancer (27% of all cancers) and common cause of death (16%) which occurs due to cancers among women, either in developed or developing countries. The current study aimed to assess incidence of breast cancer in west of Iran (Ilam province). METHODS: During a cross-sectional study, all documented records of patients who were referred to the health centre of Ilam province in a period of 8 years (2002-2009) were investigated and 82 files which were related to breast cancer were identified...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24527582/-study-on-the-correlation-factors-on-cd44-cd24-low-esa-lin-cell-ratio-in-breast-cancer
#14
Rong Wang, Xiao-Qin Yang, Qing Lü
OBJECTIVE: To explore the related factors on CD44+ CD24-/low ESA+ Lin- cell (breast caner stem cell) ratio in breast cancer patients. METHODS: Flow cytometry was used to analyze CD44+ CD24-/Iow ESA+ Lin- cell ratio in fresh tumor tissues of 40 breast cancer patients administered between March of 2011 and January of 2012 in West China Hospital, Sichuan University, China. Nine individual variables, such as age, clinical stage, histological grade, axillary lymph nodes metastases, immunohistochemisty (IHC) of estrogen receptor (ER), progesterone receptor (PR), C-erbB-2, and Ki-67 were selected to study their correlation with CD44+ CD24-/low ESA+ Lin- cell ratio...
January 2014: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/24292672/nuclear-loss-of-protein-arginine-n-methyltransferase-2-in-breast-carcinoma-is-associated-with-tumor-grade-and-overexpression-of-cyclin-d1-protein
#15
J Zhong, R-X Cao, J-H Liu, Y-B Liu, J Wang, L-P Liu, Y-J Chen, J Yang, Q-H Zhang, Y Wu, W-J Ding, T Hong, X-H Xiao, X-Y Zu, G-B Wen
Human protein arginine N-methyltransferase 2 (PRMT2, HRMT1L1) is a protein that belongs to the arginine methyltransferase family, and it has diverse roles in transcriptional regulation through different mechanisms depending on its binding partners. In this study, we provide evidences for the negative effect of PRMT2 on breast cancer cell proliferation in vitro and in vivo. Morever, cyclin D1, one of the key modulators of cell cycle, was found to be downregulated by PRMT2, and PRMT2 was further shown to suppress the estrogen receptor α-binding affinity to the activator protein-1 (AP-1) site in cyclin D1 promoter through indirect binding with AP-1 site, resulting in the inhibition of cyclin D1 promoter activity in MCF-7 cells...
November 27, 2014: Oncogene
https://www.readbyqxmd.com/read/24119909/-clinicopathological-features-and-prognosis-of-triple-negative-breast-cancer
#16
Chun-yan Li, Pei Wang, Sheng Zhang, Yan Liu, Jin Zhang
OBJECTIVE: This study was conducted to analyze the clinicopathological characteristics and patient survival factors in triple-negative breast cancer (TNBC). METHODS: A retrospective analysis was performed on 14 506 breast cancer patients admitted to the Departmrnt of Breast Surgery, Tianjin Medical University Cancer Hospital from January 2004 to June 2010. The correlation of pathological characteristics, recurrence time and patterns, and prognosis with TNBC was analyzed...
June 2013: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/24063181/-breast-reconstruction-after-skin-sparing-mastectomy-or-nipple-sparing-mastectomy-for-breast-cancer
#17
Jie Chen, Qing Lü, Xiaodong Wang, Hongjiang Li, Yujuan Chen, Xiaoqin Yang, Helin Zeng
OBJECTIVE: To evaluate the feasibility, oncological safety, and aesthetic result of skin-spring mastectomy (SSM) or nipple-spring mastectomy (NSM) in breast reconstruction of implant (permanent gel or expander) for breast cancer patients who were not fit for the breast conserving surgery (BCS). METHODS: Between October 2005 and July 2011, 89 women with breast caner underwent SSM or NSM, with an average age of 42.4 years (range, 19-55 years) and an average disease duration of 5...
July 2013: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/23982872/association-of-rs2233678-and-rs2233679-polymorphisms-in-the-pin1-gene-with-cancer-risk-a-meta-analysis
#18
Li Zhenzhen, Sun Ning, Liu Xianghua
To data, epidemiological studies have assessed the association between peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene polymorphisms and cancer risk, including breast cancer, hepatocellular carcinoma, lung cancer, esophageal cancer, head and neck squamous cell carcinoma, and laryngeal squamous cell cancer. However, the results of these studies remain controversial. We aimed to examine the associations between two SNPs (rs2233678 and rs2233679) of PIN1 gene and cancer risk by conducting a meta-analysis of case-control studies...
January 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/23593342/fulvestrant-induced-cell-death-and-proteasomal-degradation-of-estrogen-receptor-%C3%AE-protein-in-mcf-7-cells-require-the-csk-c-src-tyrosine-kinase
#19
Wei-Lan Yeh, Keiko Shioda, Kathryn R Coser, Danielle Rivizzigno, Kristen R McSweeney, Toshi Shioda
Fulvestrant is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antagonists or partial agonists, fulvestrant causes proteasomal degradation of ERα protein, shutting down the estrogen signaling to induce proliferation arrest and apoptosis of estrogen-dependent breast cancer cells. We performed genome-wide RNAi knockdown screenings for protein kinases required for fulvestrant-induced apoptosis of the MCF-7 estrogen-dependent human breast caner cells and identified the c-Src tyrosine kinase (CSK), a negative regulator of the oncoprotein c-Src and related protein tyrosine kinases, as one of the necessary molecules...
2013: PloS One
https://www.readbyqxmd.com/read/22576469/sgk3-is-associated-with-estrogen-receptor-expression-in-breast-cancer
#20
Jun Xu, Ma Wan, Quanyuan He, Roland L Bassett, Xiaoyong Fu, Albert C Chen, Fengtao Shi, Chad J Creighton, Rachel Schiff, Lei Huo, Dan Liu
While breast cancer mortality rate has seen a steady decline in the last few decades, advances in better treatment and diagnostic tools remain important as we come into the age of personalized therapy. In this report, we describe our studies of SGK3's role in breast cancer. SGK3 (also known as CISK) is a member of the AGC family of kinases. Our previous work indicates that SGK3 functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with Akt. Here, we show that SGK3 expression is linked to estrogen receptor (ER) both in breast caner cell lines and in primary tumor samples...
July 2012: Breast Cancer Research and Treatment
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