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https://www.readbyqxmd.com/read/27896815/how-and-why-are-calcium-currents-curtailed-in-the-skeletal-muscle-voltage-gated-calcium-channels
#1
Bernhard E Flucher, Petronel Tuluc
Voltage-gated calcium channels represent the sole mechanism converting electrical signals of excitable cells into cellular functions such as contraction, secretion, and gene regulation. Specific voltage-sensing domains detect changes in membrane potentials and control channel gating. Calcium ions entering through the channel function as second messengers regulating cell functions; with the exception of skeletal muscle, where CaV 1.1 is essentially not functioning as channel but activates calcium release from intracellular stores...
November 29, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27888581/vascular-toxicity-risk-assessment-of-mc18-and-mc70-novel-potential-diagnostic-tools-for-in-vivo-pet-studies
#2
Fabio Fusi, Miriam Durante, Claudia Sticozzi, Maria Frosini, Maria G Perrone, Nicola A Colabufo, Simona Saponara
The P-glicoprotein (P-gp) inhibitor MC18 has been recently proposed as a valuable PET tracer to measure P-gp expression in vivo. The aim of this study was to evaluate the toxic hazard towards the vasculature of MC18 along with the structurally related and more potent P-gp inhibitor MC70. Their effects on A7r5 and EA.hy926 cells viability, on the mechanical activity of fresh and cultured rat aorta rings as well as on Cav 1.2 channel current (ICa1.2 ) of A7r5 cells were studied. At concentrations >10 μM, MC18 and MC70 decreased cell viability causing evident morphological changes...
November 26, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27886057/age-related-modulations-of-aqp4-and-caveolin-1-in-the-hippocampus-predispose-the-toxic-effect-of-phoneutria-nigriventer-spider-venom
#3
Edilene S Soares, Leila M Stávale, Monique C P Mendonça, Andressa Coope, Maria Alice da Cruz-Höfling
We have previously demonstrated that Phoneutria nigriventer venom (PNV) causes blood-brain barrier (BBB) breakdown, swelling of astrocytes end-feet and fluid permeation into brain interstitium in rats. Caveolae and water channels respond to BBB alterations by co-participation in shear stress response and edema formation/resolution. Herein, we showed post-natal developmental-related changes of two BBB-associated transporter proteins: the endothelial caveolin-1 (Cav-1), the major scaffolding protein from caveolae frame, and the astroglial aquaporin-4 (AQP4), the main water channel protein expressed in astrocytic peri-vascular end-feet processes, in the hippocampus of rats intraperitoneally-administered PNV...
November 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27882079/overexpression-of-caveolin-1-reduces-taxol-resistance-in-human-osteosarcoma-cells-by-attenuating-pi3k-akt-jnk-dependent-autophagy
#4
Jian Guan, Zhenchao Yuan, Juliang He, Zhenjie Wu, Bin Liu, Xiang Lin, Ligen Mo, Hao Mo
Caveolin-1 (CAV-1), which is an oncoprotein and a tumor suppressor, is highly expressed in normal osteoblasts. Although researchers have investigated its role in human osteosarcoma, the mechanism of caveolin-1 action in osteosarcoma remains unknown. In the present study, Saos-2 and U-2 OS cells were cultured with a continuous induction protocol of gradually increasing Taxol concentration for 6 months to establish drug-resistant cell lines. CAV-1 expression levels in osteosarcoma cells were detected via western blotting and quantitative polymerase chain reaction...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27853367/caveolin-1-contributes-to-realgar-nanoparticle-therapy-in-human-chronic-myelogenous-leukemia-k562-cells
#5
Dan Shi, Yan Liu, Ronggang Xi, Wei Zou, Lijun Wu, Zhiran Zhang, Zhongyang Liu, Chao Qu, Baoli Xu, Xiaobo Wang
Chronic myelogenous leukemia (CML) is characterized by the t(9;22) (q34;q11)-associated Bcr-Abl fusion gene, which is an essential element of clinical diagnosis. As a traditional Chinese medicine, realgar has been widely used for the treatment of various diseases for >1,500 years. Inspired by nano-drug, realgar nanoparticles (NPs) have been prepared with an average particle size of <100 nm in a previous work. Compared with coarse realgar, the realgar NPs have higher bioavailability. As a principal constituent protein of caveolae, caveolin-1 (Cav-1) participates in regulating various cellular physiological and pathological processes including tumorigenesis and tumor development...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27847199/triptolide-inhibits-the-migration-and-invasion-of-human-prostate-cancer-cells-via-caveolin-1-cd147-mmps-pathway
#6
Shiqi Yuan, Liping Wang, Xixi Chen, Bo Fan, Qingmin Yuan, Han Zhang, Deyong Yang, Shujing Wang
Prostate cancer (PCa) is the second most common type of carcinoma and the 5th leading cause of cancer-related death in males. Triptolide, is a main and effective component of Tripterygium wilfordii Hook F, which exerts an broad-spectrum anti-malignant tumor function. However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27832597/caveolin-1-regulation-of-disrupted-in-schizophrenia-1-as-a-potential-therapeutic-target-for-schizophrenia
#7
Adam Kassan, Junji Egawa, Zheng Zhang, Angels Almenar-Queralt, Quynh My Nguyen, Yasaman Lajevardi, Kaitlyn Kim, Edmund Posadas, Dilip V Jeste, David M Roth, Piyush M Patel, Hemal H Patel, Brian P Head
BACKGROUND: Schizophrenia is a debilitating psychiatric disorder manifested in early adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptible gene for schizophrenia (54, 76, 101) implicated in neuronal development, brain maturation and neuroplasticity (12, 20). Therefore, DISC1 is a promising candidate gene for schizophrenia, but the molecular mechanisms underlying its role in the pathogenesis of the disease are still poorly understood. Interestingly, Caveolin-1 (Cav-1), a cholesterol binding and scaffolding protein, regulates neuronal signal transduction and promotes neuroplasticity...
November 2, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27805790/interplay-among-distinct-ca-2-conductances-drives-ca-2-sparks-stocs-in-rat-cerebral-arteries
#8
Ahmed M Hashad, Neil Mazumdar, Monica Romero, Anders Nygren, Kamran Bigdely-Shamloo, Osama F Harraz, Jose L Puglisi, Edward J Vigmond, Sean M Wilson, Donald G Welsh
Ca(2+) sparks are generated in a voltage dependent manner to initiate spontaneous transient outward currents (STOC), events that moderate arterial constriction. In this study, we defined the mechanisms by which membrane depolarization increases Ca(2+) sparks and subsequent STOC production. Using perforated patch clamp electrophysiology and rat cerebral arterial myocytes, we monitored STOC in the presence and absence of agents that modulate Ca(2+) entry. Beginning with CaV 3.2 inhibition, Ni(2+) was shown to decrease STOC frequency in cells held at hyperpolarized (-40 mV) but not depolarized (-20 mV) voltages...
November 2, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27796700/benzophenone-3-increases-metastasis-potential-in-lung-cancer-cells-via-epithelial-to-mesenchymal-transition
#9
Preeyaporn Plaimee Phiboonchaiyanan, Kesarin Busaranon, Chuanpit Ninsontia, Pithi Chanvorachote
Exposure to compounds with cancer-potentiating effects can contribute to the progression of cancer. Herein we have discovered for the first time that benzophenone-3 (BP-3), a chemical used as sunscreen in various cosmetic products, enhances the ability of lung cancer cells to undergo metastasis. The exposure of the lung cancer cells to BP-3 at non-toxic concentrations significantly increased the number of anoikis resistant cells in a dose-dependent manner. Also, BP-3 increased the growth rate as well as the number of colonies accessed by anchorage-independent growth assay...
October 28, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27796367/serological-and-molecular-epidemiology-of-canine-adenovirus-type-1-in-red-foxes-vulpes-vulpes-in-the-united-kingdom
#10
David Walker, Seán A Fee, Gill Hartley, Jane Learmount, Maria J H O'Hagan, Anna L Meredith, Barend M de C Bronsvoort, Thibaud Porphyre, Colin P Sharp, Adrian W Philbey
Canine adenovirus type 1 (CAV-1) causes infectious canine hepatitis (ICH), a frequently fatal disease which primarily affects canids. In this study, serology (ELISA) and molecular techniques (PCR/qPCR) were utilised to investigate the exposure of free-ranging red foxes (Vulpes vulpes) to CAV-1 in the United Kingdom (UK) and to examine their role as a wildlife reservoir of infection for susceptible species. The role of canine adenovirus type 2 (CAV-2), primarily a respiratory pathogen, was also explored. In foxes with no evidence of ICH on post-mortem examination, 29 of 154 (18...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27773611/involvement-of-caveolin-1-in-low-shear-stress-induced-breast-cancer-cell-motility-and-adhesion-roles-of-fak-src-and-rock-p-mlc-pathways
#11
Niya Xiong, Shun Li, Kai Tang, Hongxia Bai, Yueting Peng, Hong Yang, Chunhui Wu, Yiyao Liu
Tumor cells translocating to distant sites are subjected to hemodynamic shear forces during their passage in the blood vessels. Low shear stress (LSS) plays a critical role in the regulation of various aspects of tumor cells functions, including motility and adhesion. Beyond its structural role, caveolin-1 (Cav-1), the important component of caveolae, represents a modulator of several cancer-associated functions as tumor progression and metastasis. However, the role of Cav-1 in regulating tumor cells response to shear stress remains poorly explored...
October 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27768988/pyrogallol-abates-vsmc-migration-via-modulation-of-caveolin-1-matrix-metalloproteinase-and-intima-hyperplasia-in-carotid-ligation-mouse
#12
Yu-Dong Ma, Varadharajan Thiyagarajan, May-Jywan Tsai, Sheng-I Lue, Yi-Chen Chia, Song-Kun Shyue, Ching-Feng Weng
Migration of vascular smooth muscle cells (VSMCs) contributes to intimal hyperplasia and other vascular diseases. Caveolin-1 (Cav-1) has been recognized as a proliferative inhibitor of VSMCs and is likely to be an important regulator of VSMC migration. The underlying mechanism of pyrogallol on the VSMC migration is not fully understood. This study attempted to dissect the role of Cav-1 and matrix metalloproteinase (MMP) in VSMC migration and to investigate the effect of pyrogallol on VSMC mobility during carotid artery ligation mice...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27764093/high-caveolin-1-expression-in-tumor-stroma-is-associated-with-a-favourable-outcome-in-prostate-cancer-patients-managed-by-watchful-waiting
#13
Peter Hammarsten, Tove Dahl Scherdin, Christina Hägglöf, Pernilla Andersson, Pernilla Wikström, Pär Stattin, Lars Egevad, Torvald Granfors, Anders Bergh
In the present study we have investigated whether Caveolin-1 expression in non-malignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients managed by watchful waiting. Caveolin-1 was measured in prostate tissues obtained through transurethral resection of the prostate from 395 patients diagnosed with prostate cancer. The majority of the patients (n = 298) were followed by watchful waiting after diagnosis. Tissue microarrays constructed from malignant and non-malignant prostate tissue were stained with an antibody against Caveolin-1...
2016: PloS One
https://www.readbyqxmd.com/read/27761489/data-supporting-attempted-caveolae-mediated-phagocytosis-of-surface-fixed-micro-pillars-by-human-osteoblasts
#14
Caroline Moerke, Petra Mueller, Barbara Nebe
The provided data contains the phagocytic interaction of human MG-63 osteoblasts with micro-particles 6 µm in size as well as geometric micro-pillared topography with micro-pillar sizes 5 µm of length, width, height and spacing respectively related to the research article entitled "Attempted caveolae-mediated phagocytosis of surface-fixed micro-pillars by human osteoblasts" in the Biomaterials journal. [1] Micro-particle treatment was used as positive control triggering phagocytosis by the osteoblasts. Caveolin-1 (Cav-1) as major structural component of caveolae [2] plays an important role in the phagocytic process of micro-particles and -pillars...
June 2016: Data in Brief
https://www.readbyqxmd.com/read/27742593/helium-postconditioning-regulates-expression-of-caveolin-1-and-3-and-induces-risk-pathway-activation-after-ischaemia-reperfusion-in-cardiac-tissue-of-rats
#15
Moritz Flick, Martin Albrecht, Gezina T M L Oei, Renske Steenstra, Raphaela P Kerindongo, Coert J Zuurbier, Hemal H Patel, Markus W Hollmann, Benedikt Preckel, Nina C Weber
Caveolae, lipid enriched invaginations of the plasma membrane, are epicentres of cellular signal transduction. The structural proteins of caveolae, caveolins, regulate effector pathways in anaesthetic-induced cardioprotection, including the RISK pathway. Helium (He) postconditioning (HePoc) is known to mimic anaesthetic conditioning and to prevent damage from myocardial infarction. We hypothesize that HePoc regulates caveolin-1 and caveolin-3 (Cav-1 and Cav-3) expression in the rat heart and activates the RISK pathway...
October 11, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27708218/overexpression-of-caveolin-1-attenuates-brain-edema-by-inhibiting-tight-junction-degradation
#16
Kang-Ho Choi, Hyung-Seok Kim, Man-Seok Park, Eun-Bin Lee, Jung-Kil Lee, Joon-Tae Kim, Ja-Hae Kim, Min-Cheol Lee, Hong-Joon Lee, Ki-Hyun Cho
Cerebral edema from the disruption of the blood-brain barrier (BBB) after cerebral ischemia is a major cause of morbidity and mortality as well as a common event in patients with stroke. Caveolins (Cavs) are thought to regulate BBB functions. Here, we report for the first time that Cav-1 overexpression (OE) decreased brain edema from BBB disruption following ischemic insult. Edema volumes and Cav-1 expression levels were measured following photothrombosis and middle cerebral artery occlusion (MCAO). Endothelial cells that were transduced with a Cav-1 lentiviral expression vector were transplanted into rats...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27698803/expression-and-potential-correlation-among-forkhead-box-protein-m1-caveolin-1-and-e-cadherin-in-colorectal-cancer
#17
Jing Zhang, Kundong Zhang, Lisheng Zhou, Weidong Wu, Tao Jiang, Jun Cao, Kejian Huang, Zhengjun Qiu, Chen Huang
The aim of the present study was to investigate the expression and functions of Forkhead box protein M1 (FoxM1), Caveolin-1 (Cav-1) and E-cadherin in colorectal cancer (CRC), and to determine the correlations among these proteins in CRC development and progression. The protein expression of FoxM1, Cav-1 and E-cadherin was identified using a human CRC and normal tissue microarray. A standard immunohistochemistry assay was performed employing anti-FoxM1, anti-Cav-1 and anti-E-cadherin antibodies. The clinicopathological significance of FoxM1, Cav-1 and E-cadherin in CRC was determined, and correlations were investigated between FoxM1 and Cav-1, FoxM1 and E-cadherin, Cav-1 and E-cadherin, respectively...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27685790/the-influence-of-lipoic-acid-on-caveolin-1-regulated-antioxidative-enzymes-in-the-mouse-model-of-acute-ulcerative-colitis
#18
Aleksandra Piechota-Polanczyk, Marta Zielińska, Damian Piekielny, Jakub Fichna
AIM: This study was undertaken to verify if two-weeks treatment of lipoic acid (LA) influence colon damage and pro-inflammatory cytokine synthesis during DSS-induced acute colitis. Moreover, as LA has anti-oxidative properties, we analyzed its influence on the level of antioxidative enzymes, HO-1 and eNOS, and their regulator- caveolin-1. METHODS: LA was administrated to male C57/BALBc mice at a dose of 25 or 50mg/kg/day (i.p.) for 21days. Acute colitis was induced by administration of 4% DSS (w/v) in drinking water for 5days, followed by 2days of normal drinking water...
September 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27680666/caveolin-1-modulates-aldosterone-mediated-pathways-of-glucose-and-lipid-homeostasis
#19
Rene Baudrand, Nidhi Gupta, Amanda E Garza, Anand Vaidya, Jane A Leopold, Paul N Hopkins, Xavier Jeunemaitre, Claudio Ferri, Jose R Romero, Jonathan Williams, Joseph Loscalzo, Gail K Adler, Gordon H Williams, Luminita H Pojoga
BACKGROUND: Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav-1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav-1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav-1-null mice and humans with a prevalent variant in the CAV1 gene. METHODS AND RESULTS: In mouse studies, cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high- to low-density lipoprotein (all P<0...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27633320/stiffness-dependent-cellular-internalization-of-matrix-bound-bmp-2-and-its-relation-to-smad-and-non-smad-signaling
#20
Flora Gilde, Laure Fourel, Raphael Guillot, Isabelle Pignot-Paintrand, Takaharu Okada, Vincent Fitzpatrick, Thomas Boudou, Corinne Albiges-Rizo, Catherine Picart
: Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as an insoluble cue physically bound to a biomimetic matrix, called here matrix-bound (bBMP-2), are presented to cells by their ventral side. To date, BMP-2 internalization and signaling studies in cell biology have always been performed by adding soluble (sBMP-2) to cells adhered on cell culture plates or glass slides, which will be considered here as a "reference" condition...
December 2016: Acta Biomaterialia
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