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https://www.readbyqxmd.com/read/29436604/cav-1-2-and-cav-2-2-expression-is-regulated-by-different-endogenous-ghrelin-levels-in-pancreatic-acinar-cells-during-acute-pancreatitis
#1
Jie Zhou, Mengbin Qin, Huilin Wang, Jiaping He, Hongzong Fu, Huirong Shi, Zhihai Liang, Guodu Tang
Ghrelin influences pancreatic endocrine and exocrine functions, regulates intracellular calcium [Ca2+]i levels, and has an anti-inflammatory role in acute pancreatitis. This study investigated the role of endogenous ghrelin in the expression of Cav 1.2 (L-type of Ca2+ channel) and Cav 2.2 (N-type of Ca2+ channel) in acute pancreatitis. For this purpose, acute edematous pancreatitis (AEP) and acute necrotizing pancreatitis (ANP) rat models were established. Cav 1.2 and Cav 2.2 expression was assessed by immunohistochemistry in the pancreatic tissues of rats; ghrelin, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) serum levels were detected using ELISA...
February 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29419573/important-role-of-endothelial-caveolin-1-in-the-protective-role-of-endothelium-dependent-hyperpolarization-against-nitric-oxide-mediated-nitrative-stress-in-microcirculation-in-mice
#2
Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa
AIMS: Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a NO generating system in conduit arteries and an EDH-mediated system in resistance arteries, for which caveolin-1 (Cav-1) is involved. However, the physiological role of endothelial Cav-1 in microvessels remains to be elucidated. METHODS AND RESULTS: We newly generated endothelium-specific Cav-1-knockout (eCav-1-KO) mice...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29412114/caveolin-1-in-stroke-neuropathology-and-neuroprotection-a-novel-molecular-therapeutic-target-for-ischemic-related-injury
#3
Shanshan Wang, Brian P Head
Cardiovascular disease and associated cerebral stroke are a global epidemic attributed to genetic and epigenetic factors, such as diet, life style and an increasingly sedentary existence due to technological advances in both the developing and developed world. There are approximately 5.9 million stroke-related deaths worldwide annually. Current epidemiological data indicate that nearly 16.9 million people worldwide suffer a new or recurrent stroke yearly. In 2014 alone, 2.4% of adults in the United States (U...
February 5, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29410348/caloric-restriction-improves-glucose-homeostasis-yet-increases-cardiometabolic-risk-in-caveolin-1-deficient-mice
#4
Korapat Mayurasakorn, Nurul Hasanah, Tsuyoshi Homma, Mika Homma, Isis Katayama Rangel, Amanda E Garza, Jose R Romero, Gail K Adler, Gordon H Williams, Luminita H Pojoga
BACKGROUND AND PURPOSE: The plasma membrane protein caveolin-1 (CAV-1) has been shown to be involved in modulating glucose homeostasis and the actions of the renin-angiotensin-aldosterone system (RAAS). Caloric restriction (CR) is widely accepted as an effective therapeutic approach to improve insulin sensitivity and reduce the severity of diabetes. Recent data indicate that polymorphisms of the CAV-1 gene are strongly associated with insulin resistance, hypertension and metabolic abnormalities in non-obese individuals...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29408536/vasoactive-intestinal-peptide-inhibits-airway-smooth-muscle-cell-proliferation-in-a-mouse-model-of-asthma-via-the-erk1-2-signaling-pathway
#5
Juan Wang, Yun-Xiao Shang, Xu-Xu Cai, Li-Yun Liu
Asthma is a heterogeneous clinical syndrome characterized by airway inflammation, hyper-responsiveness and remodeling. Airway remodeling is irreversible by current antiasthmatic drugs, and it is the main cause of severe asthma. Airway smooth muscle cells (ASMCs) act as the main effector cells for airway remodeling; the proliferation and hypertrophy of which are involved in airway remodeling. Caveolin (Cav)-1 is present on the surface of ASMCs, which is involved in cell cycle and signal transduction regulation, allowing ASMCs to change from proliferation to apoptosis...
February 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29407195/effect-of-hypoxia-on-caveolae-related-protein-expression-and-insulin-signaling-in-adipocytes
#6
M Varela-Guruceaga, F I Milagro, J A Martínez, C de Miguel
Obesity is characterized by hypertrophy and hyperplasia of adipose tissue, which have been related to the development of hypoxia and insulin resistance. On the other hand, caveolin-1 (Cav-1), one of the main proteins of caveolae, promotes insulin receptor (IR) phosphorylation and the subsequent activation of insulin signaling. In this work we investigated the effect of hypoxia on Cav-1 regulation and the status of insulin signaling in 3T3-L1 adipocytes. Our results showed that hypoxia inhibited adipogenesis and insulin signaling in adipocytes...
January 30, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29380056/endothelial-dependent-dilation-following-chronic-hypoxia-involves-trpv4-mediated-activation-of-endothelial-bk-channels
#7
Jay S Naik, Benjimen R Walker
Following chronic hypoxia (CH), the systemic vasculature exhibits blunted vasoconstriction due to endothelial-dependent hyperpolarization (EDH). Previous data demonstrate that subsequent to CH, EDH-mediated vasodilation switches from a reliance on SKca and IKca channels to activation of the endothelial BKca channels (eBK). The mechanism by which endothelial cell stimulation activates eBK channels following CH is not known. We hypothesized that following CH, EDH-dependent vasodilation involves a TRPV4-dependent activation of eBK channels...
January 29, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29339715/caveolin-1-inhibits-proliferation-migration-and-invasion-of-human-colorectal-cancer-cells-by-suppressing-phosphorylation-of-epidermal-growth-factor-receptor
#8
Juanli Yang, Tienian Zhu, Ruijing Zhao, Dongmei Gao, Yujie Cui, Kun Wang, Yanli Guo
BACKGROUND Although downregulation of caveolin-1 (Cav-1), which is a key constituent of membrane caveolae and a regulator of cellular processes, is associated with colorectal cancer (CRC), its involvement in the disease progression is largely unknown. This study aimed to explore the role of Cav-1 in CRC and the associated mechanisms. MATERIAL AND METHODS Fresh tissues from patients with CRC and human CRC SW480 cells were used to evaluate Cav-1 and Ki-67 expression using immunohistochemistry and Western blotting...
January 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29299743/basic-fibroblast-growth-factor-protects-astrocytes-against-ischemia-reperfusion-injury-by-upregulating-the-caveolin-1-vegf-signaling-pathway
#9
Meixia Liu, Yudan Wu, Yidian Liu, Zhenzhen Chen, Shujuan He, Huimei Zhang, Liang Wu, Fengxia Tu, Yun Zhao, Chan Liu, Xiang Chen
A previous in vivo study demonstrated that intracerebroventricular injection of basic fibroblast growth factor (bFGF) in middle cerebral artery occlusion rats increased the expression of caveolin-1 (cav-1) and vascular endothelial growth factor (VEGF) in cerebral ischemia penumbra. Because astrocytes are the largest population in the brain, the aim of this in vitro study was to investigate the influence of bFGF on cav-1 and VEGF expression in rat astrocytes following oxygen glucose deprivation/reoxygenation (OGD/R)...
January 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29296972/bone-marrow-transplantation-prevents-right-ventricle-disease-in-the-caveolin-1-deficient-mouse-model-of-pulmonary-hypertension
#10
Kewal Asosingh, Nicholas Wanner, Kelly Weiss, Kimberly Queisser, Liya Gebreab, Biruk Kassa, Eric Stuehr, Brian Graham, Serpil Erzurum
Accumulating evidence shows a causative role for the bone marrow (BM) in the genesis and progression of pulmonary hypertension (PH). Engraftment of BM hematopoietic stem cells from PH patients to mice reproduces the cardiopulmonary pathology of PH. However, it is unknown whether healthy BM can prevent the development of right heart disease. Caveolin-1-deficient (CAV-1 KO) mice develop cardiopulmonary disease with manifestations resembling PH, including elevated right ventricular (RV) systolic pressure (RVSP), RV hypertrophy, and pulmonary endothelial proliferative disease...
March 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29286128/protection-against-monocrotaline-induced-pulmonary-arterial-hypertension-and-caveolin-1-downregulation-by-fluvastatin-in-rats
#11
Shaoping Zhu, Junyu Wang, Xianguo Wang, Jinping Zhao
Statins are Hydroxymethylglutaryl-coenzyme A reductase inhibitors, which are typically used to lower blood cholesterol. Additional beneficial effects, including improvement to pulmonary arterial hypertension (PAH), have also been confirmed. However, the mechanisms underlying this improvement have not yet been clarified. The present study was conducted to determine if fluvastatin was protective against experimental PAH development and to investigate the potential effects of fluvastatin on caveolin‑1 (cav‑1) expression...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29259049/scleroderma-fibroblasts-suppress-angiogenesis-via-tgf-%C3%AE-caveolin-1-dependent-secretion-of-pigment-epithelium-derived-factor
#12
Vasiliki Liakouli, Jacobo Elies Comez, Yasser Mohamed El-Sherbiny, Margherita Scarcia, Gary Grant, Giuseppina Abignano, Emma C Derrett-Smith, Filomena Esteves, Paola Cipriani, Paul Emery, Christopher P Denton, Roberto Giacomelli, Georgia Mavria, Francesco Del Galdo
OBJECTIVES: Systemic sclerosis (SSc) is characterised by tissue fibrosis and vasculopathy with defective angiogenesis. Transforming growth factor beta (TGF-β) plays a major role in tissue fibrosis, including downregulation of caveolin-1 (Cav-1); however, its role in defective angiogenesis is less clear. Pigment epithelium-derived factor (PEDF), a major antiangiogenic factor, is abundantly secreted by SSc fibroblasts. Here, we investigated the effect of TGF-β and Cav-1 on PEDF expression and the role of PEDF in the ability of SSc fibroblasts to modulate angiogenesis...
December 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29250058/caveolin-1-and-caveolin-2-can-be-antagonistic-partners-in-inflammation-and-beyond
#13
REVIEW
Cecília Jacques Gonçalves de Almeida
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29237245/molecular-mechanisms-and-physiological-relevance-of-rgk-proteins-in-the-heart
#14
REVIEW
U Meza, D Beqollari, R A Bannister
The primary route of Ca2+ entry into cardiac myocytes is via 1,4-dihydropyridine-sensitive, voltage-gated L-type Ca2+ channels. Ca2+ influx through these channels influences duration of action potential and engages excitation-contraction (EC) coupling in both the atria and the myocardium. Members of the RGK (Rad, Rem, Rem2 and Gem/Kir) family of small GTP-binding proteins are potent, endogenously expressed inhibitors of cardiac L-type channels. Although much work has focused on the molecular mechanisms by which RGK proteins inhibit the CaV 1...
December 13, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29221162/caveolin-1-mediated-stat3-activation-determines-electrotaxis-of-human-lung-cancer-cells
#15
Li Li, Kejun Zhang, Conghua Lu, Qin Sun, Sanjun Zhao, Lin Jiao, Rui Han, Caiyu Lin, Jianxin Jiang, Min Zhao, Yong He
Migration of cancer cells leads to the invasion of distant organs by primary tumors. Further, endogenous electric fields (EFs) in the tumor microenvironment direct the migration of lung cancer cells by a process referred to as electrotaxis - although the precise mechanism remains unclear. Caveolin-1 (Cav-1) is a multifunctional scaffolding protein that is associated with directional cell migration and lung cancer invasion; however, its precise role in lung cancer electrotaxis is unknown. In the present study, we first detected outward electric currents on the tumor body surface in lung cancer xenografts using a highly-sensitive vibrating probe...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211809/down-regulation-of-the-klf5-c-myc-interaction-due-to-klf5-phosphorylation-mediates-resveratrol-repressing-the-caveolin-1-transcription-through-the-pi3k-pkd1-akt-pathway
#16
Hui Yang, Qiuxia Chen, Fangyun Sun, Nana Zhao, Lirong Wen, Lin Li, Gai Ran
Resveratrol (RSV), a natural polyphenol, has been reported to produce effect on genes transcription in lipid metabolism. In this study, we aim to explore the novel mechanisms of RSV on the regulation of caveolin-1 (Cav-1) transcription. Via body weight, blood glucose, serum lipid, and liver pathology detection, we found that RSV decreased body weight, blood glucose and lipid accumulation in rats fed high-fat diet. Based on co-immunoprecipitation (Co-IP) and western blotting assay, we found that RSV up-regulated klf5 phosphorylation and decreased the interaction of klf5 with c-Myc, which were accompanied by down-regulation of Cav-1 expression in livers of rats fed with high-fat diet...
2017: PloS One
https://www.readbyqxmd.com/read/29207674/genetic-polymorphisms-in-caveolin-1-associate-with-breast-cancer-risk-in-chinese-han-population
#17
Meng Wang, Tian Tian, Xiaobin Ma, Wenge Zhu, Yan Guo, Zhao Duan, Jiangbo Fan, Shuai Lin, Kang Liu, Yi Zheng, Qianwen Sheng, Zhi-Jun Dai, Huixia Peng
Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between CAV-1 polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in CAV-1 using the Sequenom MassARRAY method...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203526/caveolin-1-regulates-lipid-droplet-metabolism-in-endothelial-cells-via-autocrine-prostacyclin-stimulated-camp-mediated-lipolysis
#18
Andrew Kuo, Monica Y Lee, Kui Yang, Richard W Gross, William C Sessa
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in almost all eukaryotic cells and LD associated proteins tightly regulate their dynamics. One LD coat proteins is caveolin-1 (Cav-1), an essential component for caveolae assembly in highly differentiated cells including adipocytes, smooth muscle cells and endothelial cells (EC). However, the role of Cav-1 in LD dynamics is unclear. Here, we report that EC lacking Cav-1 exhibit impaired LD formation. The decreased LD formation was due to due to enhanced  lipolysis, and not caused by reduced triglyceride synthesis or fatty acid uptake...
December 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29193480/rhabdomyolysis-and-fluctuating-asymptomatic-hyperckemia-associated-with-cacna1s-variant
#19
C Anandan, M A Cipriani, R S Laughlin, Z Niu, M Milone
BACKGROUND AND PURPOSE: CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy. RYR1 mutations result in congenital myopathy, malignant hyperthermia and rhabdomyolysis. METHODS: The aim was to describe a novel phenotype associated with a CACNA1S variant at a site previously linked to hypokalemic periodic paralysis...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29191295/changes-in-outcomes-of-cardiac-allograft%C3%A2-vasculopathy-over-30-years-following-heart-transplantation
#20
Maxime Tremblay-Gravel, Normand Racine, Simon de Denus, Anique Ducharme, Guy B Pelletier, Geneviève Giraldeau, Mark Liszkowski, Marie-Claude Parent, Michel Carrier, Annik Fortier, Michel White
OBJECTIVES: This study investigated temporal changes in the demographics and the prognosis of cardiac allograft vasculopathy (CAV) over 30 years following heart transplantation (HTx). BACKGROUND: Effects of the changing HTx demographics on CAV outcomes, based on International Society for Heart and Lung Transplantation (ISHLT) classification of CAV, have been incompletely investigated. METHODS: Patients who underwent HTx at the Montreal Heart Institute were classified according to the severity of CAV (CAV 0 is no presence of CAV; CAV 1 is mild, CAV 2 to 3 is moderate to severe) and era of HTx (early: 1983 to 1998; recent: 1999 to 2011)...
December 2017: JACC. Heart Failure
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