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https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#1
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28109168/integrated-omics-analysis-of-specialized-metabolism-in-medicinal-plants
#2
Amit Rai, Kazuki Saito, Mami Yamazaki
Medicinal plants are the rich source of highly diverse specialized metabolites with important pharmacological properties. Until recently, plant biologists were limited in their approach to explore biosynthetic pathways of these metabolites, mainly due to the scarcity of plant genomics resources. Recent advancements in the high-throughput large-scale analytical methods have enabled plant biologists to discover biosynthetic pathways for important plant-based medicinal metabolites. Reduced cost to generate omics datasets, and the development of computational tools for their analysis and integration have led to the elucidation of biosynthetic pathways of several plant origin bio-active metabolites...
January 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28109126/a-step-wise-approach-to-define-binding-mechanisms-of-surrogate-viral-particles-to-multi-modal-anion-exchange-resin-in-a-single-solute-system
#3
Matthew Brown, Sarah Johnson, Kurt Brorson, Scott Lute, David Roush
Multi-modal anion exchange resins combine properties of both anion exchange and hydrophobic interaction chromatography for commercial protein polishing and may provide some viral clearance as well. From a regulatory viral clearance claim standpoint, it is unclear if multi-modal resins are truly orthogonal to either single-mode anion exchange or hydrophobic interaction columns. To answer this, a strategy of solute surface assays and High Throughput Screening of resin in concert with a scale-down model of large scale chromatography purification was employed to determine the predominant binding mechanisms of a panel of bacteriophage (i...
January 21, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28109124/domestication-and-human-demographic-history-in-south-america
#4
S Ivan Perez, María Bárbara Postillone, Diego Rindel
OBJECTIVES: The early groups of hunter-gatherers who peopled South America faced significant ecological changes in their trophic niche for a relatively short period after the initial peopling. In particular, the incorporation of cultigens during the Holocene led to a wider trophic niche and probably to an increased carrying capacity of the environment. Here, we study the relationship between the incorporation of domestic resources during the Holocene and the demographic dynamics of human populations at a regional scale in South America...
January 21, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28109107/-efficacy-of-repetitive-transcranial-magnetic-stimulation-for-alleviating-clinical-symptoms-and-suicidal-ideation-in-elderly-depressive-patients-a-randomized-controlled-trial
#5
Bi-Yong Qin, Li-Lei Dai, Yan Zheng
OBJECTIVE: To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression. METHODS: A total of 178 elderly depressive patients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109060/morphine-pharmacodynamics-in-mechanically-ventilated-preterm-neonates-undergoing-endotracheal-suctioning
#6
P A Välitalo, Ehj Krekels, M van Dijk, Shp Simons, D Tibboel, Caj Knibbe
To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about its efficacy are ambiguous. This work presents an analysis of a previously published study on pain measurements in mechanically ventilated preterm neonates who received either morphine or placebo to improve comfort during invasive ventilation. The research question was whether morphine reduces the pain associated with endotracheal or nasal suctioning before, during, and after suctioning. Because these neonates cannot verbalize their pain levels, pain was assessed on the basis of several validated pain measurement instruments (i...
January 21, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28109027/amplitude-integrated-electroencephalography-can-predict-neurodevelopmental-outcome-at-12-months-of-corrected-age-in-very-preterm-infants
#7
Elisabeth Ralser, Vera Neubauer, Ulrike Pupp-Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
AIM: It is difficult to find diagnostic tools than can reliably predict neurodevelopmental outcomes in very preterm infants in clinical practice. This study evaluated whether amplitude-integrated electroencephalography predicted neurodevelopmental outcome in preterm infants when they reached 12 months of corrected age. METHODS: Between October 2007 and December 2013 we studied 232 preterm infants (51% male) at Innsbruck Medical University Hospital, Austria. Their mean birth weight was 1,264 grams and their mean gestational age was 29...
January 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28108996/physical-activity-and-risk-of-endometrial-cancer-in-the-norwegian-women-and-cancer-nowac-study
#8
Kristin B Borch, Elisabete Weiderpass, Tonje Braaten, Mie Jareid, Oxana A Gavrilyuk, Idlir Licaj
Few studies have investigated the association between endometrial cancer and physical activity (PA) using repeated measures of PA and different subtypes of endometrial cancer. We aimed to investigate the association between endometrial cancer and PA level at two points in time in women with different body mass index (BMI) profiles, and to calculate the population attributable fraction (PAF) of endometrial cancer for low PA levels. We included 82,759 women with complete information on PA at baseline in the Norwegian Women and Cancer Study; 52,370 had follow-up information on PA...
January 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28108993/experience-from-a-multi-country-initiative-to-improve-the-monitoring-of-selected-reproductive-health-indicators-in-africa
#9
Maria Barreix, Özge Tunçalp, Namuunda Mutombo, Ayotunde A Adegboyega, Lale Say
Universal access to sexual and reproductive health remains part of the unfinished business of global development in the Africa. To achieve it, health interventions should be monitored using programmatic indicators. WHO's Strengthening Measurement of Reproductive Health Indicators in Africa initiative, implemented in Ghana, Nigeria, Kenya, Uganda, and Zimbabwe, aimed to improve national information systems for routine monitoring of reproductive health indicators. Participating countries developed action plans employing a two-pronged strategy: (1) revising, standardizing, and harmonizing existing information-system reproductive health indicators; and (2) building data-collection capacity through training and supervision at select pilot sites...
January 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28108988/blood-brain-barrier-closure-time-after-controlled-ultrasound-induced-opening-is-independent-of-opening-volume
#10
Meaghan A O'Reilly, Olivia Hough, Kullervo Hynynen
OBJECTIVES: Microbubble-mediated focused ultrasound (US) opening of the blood-brain barrier (BBB) has shown promising results for the treatment of brain tumors and conditions such as Alzheimer disease. Practical clinical implementation of focused US treatments would aim to treat a substantial portion of the brain; thus, the safety of opening large volumes must be investigated. This study investigated whether the opened volume affects the time for the BBB to be restored after treatment...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108944/the-seroprevalence-of-antithyroid-peroxidase-antibodies-in-bipolar-families-and-bipolar-twins-results-from-two-longitudinal-studies
#11
G Snijders, L de Witte, E Mesman, S Kemner, R Vonk, R Brouwer, W A Nolen, H A Drexhage, M H J Hillegers
BACKGROUND: Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development. OBJECTIVES: Here we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a 'trait' marker for BD...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28108876/concordance-between-self-report-and-performance-based-measures-of-everyday-functioning-in-hiv-associated-neurocognitive-disorders
#12
Talia N Shirazi, Angela C Summers, Bryan R Smith, Sally R Steinbach, Suad Kapetanovic, Avindra Nath, Joseph Snow
Self-report is typically used to differentiate between asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorder (MND) in the assessment of HIV-associated neurocognitive disorders (HAND). Yet, it is unclear whether the lack of self-reported functional impairments in individuals with ANI is indicative of a genuine absence of functional impairment, or of inaccurate self-reports. In the present study, we examined the relationship between previously validated self-report (patient's assessment of own functioning inventory; instrumental activities of daily living inventory) and performance-based (the Texas Functional Living Scale) measures of functional abilities in 112 virologically-controlled HIV-infected, and 40 well-matched, HIV-uninfected participants...
January 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#13
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
January 20, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28108855/causes-of-poor-outcome-in-patients-admitted-with-good-grade-subarachnoid-haemorrhage
#14
Vladimír Beneš, Lubomír Jurák, Radim Brabec, Nina Nechanická, Miroslav Šercl, Ladislav Endrych, Pavel Buchvald, Petr Suchomel
BACKGROUND: Surgical risk in patients with unruptured aneurysms is well known. The relative impact of surgery and natural history of subarachnoid haemorrhage (SAH) on patients in good clinical condition (World Federation of Neurological Surgeons [WFNS] grades 1 and 2) is less well quantified. The aim of this study was to determine causes of poor outcome in patients admitted in good grade SAH. METHODS: A retrospective study of prospectively collected data among WFNS-1 and -2 patients: demographics, SAH and aneurysm-related data, surgical complications and outcome as assesed by the Glasgow Outcome Scale (GOS)...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108819/preemptive-treatment-with-xonrid%C3%A2-a-medical-device-to-reduce-radiation-induced-dermatitis-in-head-and-neck-cancer-patients-receiving-curative-treatment-a-pilot-study
#15
Nicola Alessandro Iacovelli, Simona Naimo, Francesca Bonfantini, Anna Cavallo, Paolo Bossi, Carlo Fallai, Emanuele Pignoli, Salvatore Alfieri, Cristiana Bergamini, Federica Favales, Ester Orlandi
PURPOSE: The purpose of this study was to investigate efficacy, safety and tolerability of Xonrid®, a new medical device, in preventing radiation dermatitis associated with head and neck cancer (HNC) radiotherapy (RT). METHODS: In this monocentric, prospective pilot study, adult consecutive HNC patients who were planned to receive curative RT with or without chemotherapy were enrolled. Patients were instructed to apply Xonrid® on the irradiated area during treatment continuing until 2 weeks after the completion of RT or the development of severe skin toxicity...
January 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28108793/effective-cerebrovascular-thrombectomy-requires-well-organized-structures-real-world-experiences-of-a%C3%A2-regional-stroke-network-between-2012-2015
#16
Maria Sophie Stockinger, Johannes Trenkler, Tim von Oertzen, Karin Nussbaumer, Michael Sonnberger, Wolfgang Schimetta, Anthony C Pereira, Gerhard Traxler, Claudia Dorninger, Hans-Peter Haring
BACKGROUND: The objective of this study was to analyse the Neurothrombectomy Network registry of the Neuromed Campus (NMC) of the Kepler University Hospital in Linz (Austria). The data were compared to the results of recently published thrombectomy trials (MR CLEAN, ESCAPE, EXTEND-IA, SWIFT-PRIME, REVASCAT and THRACE). METHODS: We retrospectively studied 246 patients with acute ischemic stroke who underwent thrombectomy between January 2012 and December 2015 at the NMC in Upper Austria...
January 20, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28108773/effects-of-caffeine-on-alcohol-reinforcement-beverage-choice-self-administration-and-subjective-ratings
#17
Mary M Sweeney, Steven E Meredith, Daniel P Evatt, Roland R Griffiths
RATIONALE: Combining alcohol and caffeine is associated with increased alcohol consumption, but no prospective experimental studies have examined whether added caffeine increases alcohol consumption. OBJECTIVES: This study examined how caffeine alters alcohol self-administration and subjective reinforcing effects in healthy adults. METHODS: Thirty-one participants completed six double-blind alcohol self-administration sessions: three sessions with alcohol only (e...
January 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28108759/from-microhabitat-of-floral-nectar-up-to-biogeographic-scale-novel-insights-on-neutral-and-niche-bacterial-assemblies
#18
Yana Aizenberg-Gershtein, Ido Izhaki, Malka Halpern
Microbial model systems are very useful in addressing macro-ecological questions. Two major theories exist to date, to explain the community structure of organisms: (1) the dispersal (neutral) assembly theory which predicts that community similarity decreases with increasing geographic distance, independent of any environmental variables, and (2) the niche assembly theory which predicts that the communities' compositions are more homogeneous among sites characterized by similar environmental conditions. Our study system offered a unique opportunity to investigate the relative role of environmental conditions and spatial factors in shaping community composition...
January 20, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28108701/willingness-to-use-and-have-sex-with-men-taking-hiv-pre-exposure-prophylaxis-prep-results-of-online-surveys-of-australian-gay-and-bisexual-men-2011-2015
#19
Martin Holt, Toby Lea, Heather-Marie Schmidt, Johann Kolstee, Jeanne Ellard, Dean Murphy, Hong-Ha Truong, John de Wit
OBJECTIVE: Assess willingness to use HIV pre-exposure prophylaxis (PrEP), support for others using it and willingness to have sex with partners using PrEP among Australian gay and bisexual men (GBM). METHODS: National, online cross-sectional surveys of Australian GBM were conducted in 2011, 2013 and 2015. Scales measuring support for and willingness to have sex with men using PrEP were developed in 2015 using factor analysis. Trends and associations with key measures were analysed using multivariate logistic regression...
January 20, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28108668/ultraviolet-and-yellow-reflectance-but-not-fluorescence-is-important-for-visual-discrimination-of-conspecifics-by-heliconius-erato
#20
Susan D Finkbeiner, Dmitry A Fishman, Daniel Osorio, Adriana D Briscoe
Toxic Heliconius butterflies have yellow hindwing bars that - unlike their closest relatives - reflect ultraviolet (UV) and long wavelength light, and also fluoresce. The pigment in the yellow scales is 3-hydroxy-DL-kynurenine (3-OHK), found also in the hair and scales of a variety of animals. In other butterflies like pierids with color schemes characterized by independent sources of variation in UV and human-visible yellow/orange, behavioral experiments have generally implicated the UV component as most relevant to mate choice...
January 20, 2017: Journal of Experimental Biology
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