Qian Zhang, Wen Wang, Hongyuan Shen, Hongyu Tao, Yating Wu, Liyuan Ma, Guangfei Yang, Ruijiao Chang, Jiaxing Wang, Hanfei Zhang, Chenyu Wang, Furong Zhang, Jiaojiao Qi, Chengrong Mi
The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core-shell structure...
April 29, 2021: Nanoscale Research Letters