Qian-Li Ma, Mai-Ou Shen, Ning Han, Hua-Zhen Xu, Xing-Chun Peng, Qi-Rui Li, Ting-Ting Yu, Liu-Gen Li, Xiang Xu, Bin Liu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
OBJECTIVE: Photodynamic therapy (PDT) has emerged as a promising strategy in the treatment of malignant tumors due to its high selectivity, non-toxicity, and non-invasiveness. However, PDT can also induce DNA damage and subsequent repair response, which may reduce the efficacy of PDT. In the present study, we sought to explore the effect of chlorin e6 (Ce6)-mediated PDT on DNA damage and DNA damage response (DDR) in lung cancer cells. In addition, the effect of PDT combined with ATM inhibitor on molecules of DDR and the possibility of improving the efficacy of PDT were further investigated...
November 22, 2021: Photodiagnosis and Photodynamic Therapy