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Hybrid allele expression development

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https://www.readbyqxmd.com/read/29738104/differential-expression-networks-and-inheritance-patterns-of-long-non-coding-rnas-in-castor-bean-seeds
#1
Wei Xu, Tianquan Yang, Bin Wang, Bing Han, Huangkai Zhou, Yue Wang, De-Zhu Li, Aizhong Liu
Long non-coding RNAs (lncRNAs) serve as versatile regulators of plant growth and development. The potential functions and inheritance patterns of lncRNAs, as well as the epigenetic regulation of lncRNA itself, remain largely uncharacterized in plant seeds, especially in the persistent endosperm of the dicotyledons. In this study, we investigated diverse RNA-seq data and catalogued 5,356 lncRNAs in castor bean seeds. A small fraction of lncRNAs were transcribed from the same direction as the promoters of protein-coding genes (PCgenes) and exhibited strongly coordinated expression with the nearby PCgene...
May 8, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29735606/allele-specific-control-of-replication-timing-and-genome-organization-during-development
#2
Juan Carlos Rivera-Mulia, Andrew Dimond, Daniel Vera, Claudia Trevilla-Garcia, Takayo Sasaki, Jared Zimmerman, Catherine Dupont, Joost Gribnau, Peter Fraser, David M Gilbert
DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional activity and 3D genome organization. Here, we derived distinct cell types from F1 hybrid musculus X castaneus mouse crosses and exploited the high single nucleotide polymorphism (SNP) density to characterize allelic differences in RT (Repli-seq), genome organization (Hi-C and promoter-capture Hi-C), gene expression (total nuclear RNA-seq) and chromatin accessibility (ATAC-seq)...
May 7, 2018: Genome Research
https://www.readbyqxmd.com/read/29686627/burst-like-transcription-of-mutant-and-wildtype-myh7-alleles-as-possible-origin-of-cell-to-cell-contractile-imbalance-in-hypertrophic-cardiomyopathy
#3
Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G Dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft
Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the HCM-phenotype is thought to be triggered by the different mutations, a common mechanism remains elusive. Studying missense-mutations in the ventricular beta-myosin heavy chain (β-MyHC, MYH7 ) we hypothesized that significant contractile heterogeneity exists among individual cardiomyocytes of HCM-patients that results from cell-to-cell variation in relative expression of mutated vs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29663588/from-transects-to-transcripts-teasing-apart-the-architecture-of-reproductive-isolation
#4
Jill A Hamilton, Joshua M Miller
Understanding the processes underlying speciation has long been a challenge to evolutionary biologists. This spurs from difficulties teasing apart the various mechanisms that contribute to the evolution of barriers to reproduction. The study by Rafati et al. () in this issue of Molecular Ecology combines spatially explicit whole-genome resequencing with evaluation of differential gene expression across individuals with mixed ancestry to associate the genomic architecture of reproductive barriers with expression of reproductive incompatibilities...
March 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29617374/genome-wide-association-studies-reveal-that-members-of-bhlh-subfamily-16-share-a-conserved-function-in-regulating-flag-leaf-angle-in-rice-oryza-sativa
#5
Haijiao Dong, Hu Zhao, Shuangle Li, Zhongmin Han, Gang Hu, Chang Liu, Gaiyu Yang, Gongwei Wang, Weibo Xie, Yongzhong Xing
As a major component of ideal plant architecture, leaf angle especially flag leaf angle (FLA) makes a large contribution to grain yield in rice. We utilized a worldwide germplasm collection to elucidate the genetic basis of FLA that would be helpful for molecular design breeding in rice. Genome-wide association studies (GWAS) identified a total of 40 and 32 QTLs for FLA in Wuhan and Hainan, respectively. Eight QTLs were commonly detected in both conditions. Of these, 2 and 3 QTLs were identified in the indica and japonica subpopulations, respectively...
April 4, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29593029/genetic-dissection-of-a-supergene-implicates-tfap2a-in-craniofacial-evolution-of-threespine-sticklebacks
#6
Priscilla A Erickson, Jiyeon Baek, James C Hart, Phillip A Cleves, Craig T Miller
In nature, multiple adaptive phenotypes often coevolve and can be controlled by tightly linked genetic loci known as supergenes. Dissecting the genetic basis of these linked phenotypes is a major challenge in evolutionary genetics. Multiple freshwater populations of threespine stickleback fish ( Gasterosteus aculeatus ) have convergently evolved two constructive craniofacial traits, longer branchial bones and increased pharyngeal tooth number, likely as adaptations to dietary differences between marine and freshwater environments...
March 28, 2018: Genetics
https://www.readbyqxmd.com/read/29531066/cross-resistance-to-dicamba-2-4-d-and-fluroxypyr-in-kochia-scoparia-is-endowed-by-a-mutation-in-an-aux-iaa-gene
#7
Sherry LeClere, Chenxi Wu, Philip Westra, R Douglas Sammons
The understanding and mitigation of the appearance of herbicide-resistant weeds have come to the forefront of study in the past decade, as the number of weed species that are resistant to one or more herbicide modes of action is on the increase. Historically, weed resistance to auxin herbicides has been rare, but examples, such as Kochia scoparia L. Schrad (kochia), have appeared, posing a challenge to conventional agricultural practices. Reports of dicamba-resistant kochia populations began in the early 1990s in areas where auxin herbicides were heavily utilized for weed control in corn and wheat cropping systems, and some biotypes are resistant to other auxin herbicides as well...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29444201/hierarchical-analysis-of-rna-seq-reads-improves-the-accuracy-of-allele-specific-expression
#8
Narayanan Raghupathy, Kwangbom Choi, Matthew J Vincent, Glen L Beane, Keith Sheppard, Steven C Munger, Ron Korstanje, Fernando Pardo-Manual de Villena, Gary A Churchill, Alfonso Valencia
Motivation: Allele-specific expression (ASE) refers to the differential abundance of the allelic copies of a transcript. RNA sequencing (RNA-Seq) can provide quantitative estimates of ASE for genes with transcribed polymorphisms. When short-read sequences are aligned to a diploid transcriptome, readmapping ambiguities confound our ability to directly count reads. Multi-mapping reads aligning equally well to multiple genomic locations, isoforms, or alleles can comprise the majority (>85%) of reads...
February 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29402926/cryptic-biological-invasions-a-general-model-of-hybridization
#9
Claudio S Quilodrán, Frédéric Austerlitz, Mathias Currat, Juan I Montoya-Burgos
The dispersal of non-native genes due to hybridization is a form of cryptic invasion with growing concern in evolution and conservation. This includes the spread of transgenic genes and antibiotic resistance. To investigate how genes and phenotypes are transmitted, we developed a general model that, for the first time, considers concurrently: multiple loci, quantitative and qualitative gene expression, assortative mating, dominance/recessivity inheritance and density-dependent demographic effects. Selection acting on alleles or genotypes can also be incorporated...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29391393/lrig1-is-a-haploinsufficient-tumor-suppressor-gene-in-malignant-glioma
#10
Feng Mao, Camilla Holmlund, Mahmood Faraz, Wanzhong Wang, Tommy Bergenheim, Samuel Kvarnbrink, Mikael Johansson, Roger Henriksson, Håkan Hedman
Recently, a genome-wide association study showed that a single nucleotide polymorphism (SNP) -rs11706832-in intron 2 of the human LRIG1 (Leucine-rich repeats and immunoglobulin-like domains 1) gene is associated with susceptibility to glioma. However, the mechanism by which rs11706832 affects glioma risk remains unknown; additionally, it is unknown whether the expression levels of LRIG1 are a relevant determinant of gliomagenesis. Here, we investigated the role of Lrig1 in platelet-derived growth factor (PDGF)-induced experimental glioma in mice by introducing mono-allelic and bi-allelic deletions of Lrig1 followed by inducing gliomagenesis via intracranial retroviral transduction of PDGFB in neural progenitor cells...
February 2, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29388391/exome-sequencing-in-syndromic-brain-malformations-identifies-novel-mutations-in-actb-and-slc9a6-and-suggests-baz1a-as-a-new-candidate-gene
#11
Valerie Weitensteiner, Rong Zhang, Julia Bungenberg, Matthias Marks, Jan Gehlen, Damian J Ralser, Alina C Hilger, Amit Sharma, Johannes Schumacher, Ulrich Gembruch, Waltraut M Merz, Albert Becker, Janine Altmüller, Holger Thiele, Bernhard G Herrmann, Benjamin Odermatt, Michael Ludwig, Heiko Reutter
BACKGROUND: Syndromic brain malformations comprise a large group of anomalies with a birth prevalence of about 1 in 1,000 live births. Their etiological factors remain largely unknown. To identify causative mutations, we used whole-exome sequencing (WES) in aborted fetuses and children with syndromic brain malformations in which chromosomal microarray analysis was previously unremarkable. METHODS: WES analysis was applied in eight case-parent trios, six aborted fetuses, and two children...
April 17, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29358068/single-parent-expression-is-a-general-mechanism-driving-extensive-complementation-of-non-syntenic-genes-in-maize-hybrids
#12
Jutta A Baldauf, Caroline Marcon, Andrew Lithio, Lucia Vedder, Lena Altrogge, Hans-Peter Piepho, Heiko Schoof, Dan Nettleton, Frank Hochholdinger
Maize (Zea mays L.) displays an exceptional degree of structural genomic diversity [1, 2]. In addition, variation in gene expression further contributes to the extraordinary phenotypic diversity and plasticity of maize. This study provides a systematic investigation on how distantly related homozygous maize inbred lines affect the transcriptomic plasticity of their highly heterozygous F1 hybrids. The classical dominance model of heterosis explains the superiority of hybrid plants by the complementation of deleterious parental alleles by superior alleles of the second parent at many loci [3]...
February 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29356153/mun-meristem-unstructured-encoding-a-spc24-homolog-of-ndc80-kinetochore-complex-affects-development-through-cell-division-in-arabidopsis-thaliana
#13
Jinwoo Shin, Goowon Jeong, Jong-Yoon Park, Hoyeun Kim, Ilha Lee
Kinetochore, a protein super-complex on the centromere of chromosomes, mediates chromosome segregation during cell division by providing attachment sites for spindle microtubules. The NDC80 complex, composed of four proteins, NDC80, NUF2, SPC24 and SPC25, is localized at the outer kinetochore and connects spindle fibers to the kinetochore. Although it is conserved across species, functional studies of this complex are rare in Arabidopsis. Here, we characterize a recessive mutant, meristem unstructured-1 (mun-1), exhibiting an abnormal phenotype with unstructured shoot apical meristem caused by ectopic expression of the WUSCHEL gene in unexpected tissues...
March 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29250101/perspective-is-random-monoallelic-expression-a-contributor-to-phenotypic-variability-of-autosomal-dominant-disorders
#14
Baoheng Gui, Jesse Slone, Taosheng Huang
Several factors have been proposed as contributors to interfamilial and intrafamilial phenotypic variability in autosomal dominant disorders, including allelic variation, modifier genes, environmental factors and complex genetic and environmental interactions. However, regardless of the similarity of genetic background and environmental factors, asymmetric limb or trunk anomalies in a single individual and variable manifestation between monozygotic twins have been observed, indicating other mechanisms possibly involved in expressivity of autosomal dominant diseases...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29199077/evolution-and-genetics-of-precocious-burrowing-behavior-in-peromyscus-mice
#15
Hillery C Metz, Nicole L Bedford, Yangshu Linda Pan, Hopi E Hoekstra
A central challenge in biology is to understand how innate behaviors evolve between closely related species. One way to elucidate how differences arise is to compare the development of behavior in species with distinct adult traits [1]. Here, we report that Peromyscus polionotus is strikingly precocious with regard to burrowing behavior, but not other behaviors, compared to its sister species P. maniculatus. In P. polionotus, burrows were excavated as early as 17 days of age, whereas P. maniculatus did not build burrows until 10 days later...
December 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29172230/sequential-gene-activation-and-gene-imprinting-during-early-embryo-development-in-maize
#16
Dexuan Meng, Jianyu Zhao, Cheng Zhao, Haishan Luo, Mujiao Xie, Renyi Liu, Jinsheng Lai, Xiaolan Zhang, Weiwei Jin
Gene imprinting is a widely observed epigenetic phenomenon in maize endosperm; however, whether it also occurs in the maize embryo remains controversial. Here, we used high-throughput RNA sequencing on laser capture microdissected and manually dissected maize embryos from reciprocal crosses between inbred lines B73 and Mo17 at six time points (3-13 days after pollination, DAP) to analyze allelic gene expression patterns. Co-expression analysis revealed sequential gene activation during maize embryo development...
February 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29170427/genome-wide-proteomic-profiling-reveals-the-role-of-dominance-protein-expression-in-heterosis-in-immature-maize-ears
#17
Xiaojiao Hu, Hongwu Wang, Kun Li, Yujin Wu, Zhifang Liu, Changling Huang
Heterosis refers to the phenomenon in which hybrid progeny show superior performance relative to their parents. Early maize ear development shows strong heterosis in ear architecture traits and greatly affects grain yield. To explore the underlying molecular mechanisms, genome-wide proteomics of immature ears of maize hybrid ZD909 and its parents were analyzed using tandem mass tag (TMT) technology. A total of 9,713 proteins were identified in all three genotypes. Among them, 3,752 (38.6%) proteins were differentially expressed between ZD909 and its parents...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149037/development-of-novel-polymorphic-est-ssr-markers-in-bailinggu-pleurotus-tuoliensis-for-crossbreeding
#18
Yueting Dai, Wenying Su, Chentao Yang, Bing Song, Yu Li, Yongping Fu
Identification of monokaryons and their mating types and discrimination of hybrid offspring are key steps for the crossbreeding of Pleurotus tuoliensis (Bailinggu). However, conventional crossbreeding methods are troublesome and time consuming. Using RNA-seq technology, we developed new expressed sequence tag-simple sequence repeat (EST-SSR) markers for Bailinggu to easily and rapidly identify monokaryons and their mating types, genetic diversity and hybrid offspring. We identified 1110 potential EST-based SSR loci from a newly-sequenced Bailinggu transcriptome and then randomly selected 100 EST-SSRs for further validation...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29138238/a-resource-for-the-allele-specific-analysis-of-dna-methylation-at-multiple-genomically-imprinted-loci-in-mice
#19
Jadiel A Wasson, Onur Birol, David J Katz
Genomically imprinted loci are expressed mono-allelically, dependent upon the parent of origin. Their regulation not only illuminates how chromatin regulates gene expression but also how chromatin can be reprogrammed every generation. Because of their distinct parent-of-origin regulation, analysis of imprinted loci can be difficult. Single nucleotide polymorphisms (SNPs) are required to accurately assess these elements allele specifically. However, publicly available SNP databases lack robust verification, making analysis of imprinting difficult...
January 4, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29101321/contribution-of-epigenetic-landscapes-and-transcription-factors-to-x-chromosome-reactivation-in-the-inner-cell-mass
#20
Maud Borensztein, Ikuhiro Okamoto, Laurène Syx, Guillaume Guilbaud, Christel Picard, Katia Ancelin, Rafael Galupa, Patricia Diabangouaya, Nicolas Servant, Emmanuel Barillot, Azim Surani, Mitinori Saitou, Chong-Jian Chen, Konstantinos Anastassiadis, Edith Heard
X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst stage. X-chromosome inactivation is then reversed in the inner cell mass. The mechanisms underlying Xp reactivation remain enigmatic. Using in vivo single-cell approaches (allele-specific RNAseq, nascent RNA-fluorescent in situ hybridization and immunofluorescence), we show here that different genes are reactivated at different stages, with more slowly reactivated genes tending to be enriched in H3meK27...
November 3, 2017: Nature Communications
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