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https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#1
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29666026/cervical-cancer-state-of-the-science-from-angiogenesis-blockade-to-checkpoint-inhibition
#2
REVIEW
Lindsey E Minion, Krishnansu S Tewari
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer. Chemotherapy doublets combined with the fully humanized monoclonal antibody, bevacizumab, now constitute first-line therapy for women struggling with recurrent/metastatic cervical carcinoma. Regulatory approval for this indication was based on the phase III randomized trial, GOG 240, which demonstrated a statistically significant and clinically meaningful improvement in overall survival when bevacizumab was added to chemotherapy: 17...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29593728/the-acid-base-balance-and-gender-in-inflammation-a-mini-review
#3
REVIEW
Georges Jacques Casimir, Nicolas Lefèvre, Francis Corazza, Jean Duchateau, Mustapha Chamekh
In humans, acid-base balance is crucial to cell homeostasis. Acidosis is observed in numerous inflammatory processes, primarily acute conditions such as sepsis, trauma, or acute respiratory distress where females tend to exhibit better prognosis compared with males. The mechanisms underlying these gender-dependent differences are multiple, probably involving hormonal and genetic factors, particularly the X chromosome. Although pH influences multiple immunological functions, gender differences in acid-base balance have been poorly investigated...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29558045/liver-dysfunction-in-sepsis
#4
REVIEW
Ewa A Woźnica, Małgorzata Inglot, Ryszard K Woźnica, Lidia Łysenko
Despite continuous progress in medicine, sepsis remains the main cause of deaths in the intensive care unit. Liver failure complicating sepsis/septic shock has a significant impact on mortality in this group of patients. The pathophysiology of sepsis-associated liver dysfunction is very complicated and still not well understood. According to the Surviving Sepsis Campaign (SSC) Guidelines, the diagnosis of liver dysfunction during sepsis is based on the increase in bilirubin concentration >2 mg/dL and the occurrence of coagulation disorders with INR > 1...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29517700/diagnostic-indicator-of-acute-lung-injury-for-pediatric-critically-ill-patients-at-a-tertiary-pediatric-hospital
#5
John Rene Labib, Sally Kamal Ibrahem, Hala Mohamed Sleem, Mohamed M Ismail, Shaimaa A M Abd El Fatah, Marwa Rashad Salem, Amaal A Abdelaal, Hadeel Al-Hanafi
Early identification of acute lung injury (ALI) in pediatric patients at risk of mortality is important for improving outcome.Assessment of soluble form of receptor for advanced glycation end products (sRAGE) as a valid biomarker for diagnosis of ALI among critically ill, pediatric patients in addition to correlating levels of sRAGE and different outcomes of those patients.A Hospital-based case-control study was conducted in pediatric intensive care units (PICUs) at Cairo University Hospital, along a period of 6 months...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29510394/cytokine-production-by-mononuclear-cells-from-patients-with-familial-infantile-bilateral-striatal-necrosis
#6
Esther Ganelin Cohen, Hanna Bessler, Meir Djaldetti, Rachel Straussberg
Prompted by findings suggesting immune instability in infantile bilateral striatal necrosis (IBSN), we evaluated levels of proinflammatory (tumor necrosis factor α, interleukin [IL]-1β, IL-6, interferon [IFN]γ) and anti-inflammatory (IL-10 and IL-1ra) cytokines produced by peripheral blood mononuclear cells (PBMC) from 6 children with IBSN and 11 age-matched controls. Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; p < 0.001) and significantly lower levels of TNFα, IL-1β, and IFNγ (by 36% [p < 0...
March 6, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29466409/il-7-treatment-augments-and-prolongs-sepsis-induced-expansion-of-il-10-producing-b-lymphocytes-and-myeloid-derived-suppressor-cells
#7
Upasana Kulkarni, Christoph Herrmenau, Stephanie J Win, Michael Bauer, Thomas Kamradt
Immunological dysregulation in sepsis is associated with often lethal secondary infections. Loss of effector cells and an expansion of immunoregulatory cell populations both contribute to sepsis-induced immunosuppression. The extent and duration of this immunosuppression are unknown. Interleukin 7 (IL-7) is important for the maintenance of lymphocytes and can accelerate the reconstitution of effector lymphocytes in sepsis. How IL-7 influences immunosuppressive cell populations is unknown. We have used the mouse model of peritoneal contamination and infection (PCI) to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29449936/function-of-aquaporins-in-sepsis-a-systematic-review
#8
REVIEW
Katharina Rump, Michael Adamzik
Background: Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic strategies is urgent. Promising drug targets or biomarkers may depict aquaporins (AQPs) as they regulate crucial key mechanisms of sepsis. Main body: Here we report on base of the current literature that several AQPs are involved in different physiological processes of sepsis. In immune system mainly AQPs 3, 5 and 9 seem to be important, as they regulate the migration of different immune cells...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29434744/interleukin-1-receptor-associated-kinase-3-downregulation-in-peripheral-blood-mononuclear-cells-attenuates-immunosuppression-in-sepsis
#9
Qin Xia, Yupin Zhou, Xi Wang, Shukun Fu
Sepsis is the leading cause of mortality in intensive care units due to complex inflammatory immune responses and immunosuppression. Recent studies have indicated that the negative regulator of toll like receptors, interleukin-1 receptor-associated kinase 3 (IRAK-3/IRAK-M), serves an important role in immunosuppression during sepsis. In the current study, a cecal ligation puncture model was established in mice using lipopolysaccharide secondary challenge to simulate immunosuppression in sepsis. Peripheral blood mononuclear cells (PBMCs) from this model were then used to evaluate the expression and function of IRAK-M...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29382531/gonadal-hormone-receptors-underlie-the-resistance-of-female-rats-to-inflammatory-and-cardiovascular-complications-of-endotoxemia
#10
Mohammed A El-Lakany, Mohamed A Fouda, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas
The male gender is more vulnerable to immunological complications of sepsis. Here, we tested the hypotheses that female rats are protected against endotoxemia-evoked hypotension and cardiac autonomic dysfunction, and that gonadal hormone receptors account for such protection. Changes in blood pressure, heart rate, and cardiac sympathovagal balance caused by i.v. lipopolysaccharide (LPS) were determined. In male rats, LPS elevated serum TNFα together with falls in blood pressure and rises in heart rate. The spectral index of cardiac sympathovagal balance (low-frequency/high-frequency ratio, LF/HF) was reduced by LPS, suggesting an enhanced parasympathetic dominance...
January 27, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29379043/early-immune-anergy-towards-recall-antigens-and-mitogens-in-patients-at-onset-of-septic-shock
#11
M Feuerecker, L Sudhoff, B Crucian, J-I Pagel, C Sams, C Strewe, A Guo, G Schelling, J Briegel, I Kaufmann, A Choukèr
The pathology of sepsis is typically characterized by an infection and excessive initial inflammation including a cytokine storm, followed by a state of immune suppression or paralysis. This classical view of a two peak kinetic immune response is currently controversially discussed. This study was a sub-study of the randomized clinical Trial SISPCT registered with www.clinicaltrials.gov (NCT00832039, Registration date: 29/01/2009). Blood samples from 76 patients with severe sepsis and septic shock were incubated for 48 h at 37 °C in vitro with bacterial or fungal recall-antigens or specific mitogen antigens within 24 hours of sepsis onset...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377225/pathogenic-mechanisms-of-invasive-group-a-streptococcus-infections-by-influenza-virus-group-a-streptococcus-superinfection
#12
REVIEW
Shigefumi Okamoto, Satoshi Nagase
Group A Streptococcus (GAS) are pathogenic bacteria of the genus Streptococcus and cause severe invasive infections that comprise a wide range of diverse diseases, including acute respiratory distress syndrome, renal failure, toxic shock-like syndrome, sepsis, cellulitis and necrotizing fasciitis. The essential virulence, infected host and external environmental factors required for invasive GAS infections have not yet been determined. Superinfection with influenza virus and GAS induced invasive GAS infections was demonstrated by our team in a mouse model, after which clinical cases of invasive GAS infections secondary to influenza virus infection were reported by other investigators in Japan, USA, Canada, UK China, and other countries...
March 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29338031/pre-existing-malignancy-results-in-increased-prevalence-of-distinct-populations-of-cd4-t-cells-during-sepsis
#13
Jianfeng Xie, Jennifer M Robertson, Ching-Wen Chen, Wenxiao Zhang, Craig M Coopersmith, Mandy L Ford
The presence of pre-existing malignancy in murine hosts results in increased immune dysregulation and risk of mortality following a septic insult. Based on the known systemic immunologic changes that occur in cancer hosts, we hypothesized that the presence of pre-existing malignancy would result in phenotypic and functional changes in CD4+ T cell responses following sepsis. In order to conduct a non-biased, unsupervised analysis of phenotypic differences between CD4+ T cell compartments, cohorts of mice were injected with LLC1 tumor cells and tumors were allowed to grow for 3 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29302904/acute-kidney-injury-in-pregnancy-with-special-reference-to-pregnancy-specific-disorders-a-hospital-based-study-2014-2016
#14
Jai Prakash, Vivek C Ganiger, Suraj Prakash, Mohammad Iqbal, Deba Prasad Kar, Usha Singh, Ashish Verma
INTRODUCTION: There are numerous reports in the literature describing acute kidney injury in pregnancy (P-AKI) due to various obstetric complications. However, there is a dearth of studies on AKI related to pregnancy-specific disorders from India. We aimed to analyze clinical features and outcome of P-AKI related to pregnancy-specific disorders compared to total pregnancy, in India. METHOD: All pregnant women attending the department of Obstetrics and Gynecology from November 2014 to July 2016 were screened for AKI based on: (1) sudden elevation of serum creatinine ≥ 1 mg/dl; (2) oligoanuria for > 12 h; and (3) need for dialysis...
February 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29295868/the-immunoproteasome-specific-inhibitor-onx-0914-reverses-susceptibility-to-acute-viral-myocarditis
#15
Nadine Althof, Carl Christoph Goetzke, Meike Kespohl, Karolin Voss, Arnd Heuser, Sandra Pinkert, Ziya Kaya, Karin Klingel, Antje Beling
Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914-an immunoproteasome-specific inhibitor-as highly protective during severe heart disease. Represented by reduced heart infiltration of monocytes/macrophages and diminished organ damage, ONX 0914 treatment reversed fulminant pathology...
February 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29277158/postoperative-symbiotic-in-patients-with-head-and-neck-cancer-a-double-blind-randomised-trial
#16
Priscilla C Lages, Simone V Generoso, Maria Isabel T D Correia
Studies on the 'gut origin of sepsis' have suggested that stressful insults, such as surgery, can affect intestinal permeability, leading to bacterial translocation. Symbiotics have been reported to be able to improve gut permeability and modulate the immunologic system, thereby decreasing postoperative complications. Therefore we aimed to evaluate the postoperative use of symbiotics in head and neck cancer surgical patients for intestinal function and permeability, as well as the postoperative outcomes. Patients were double-blind randomised into the symbiotic (n 18) or the control group (n 18)...
January 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29275601/-the-need-to-focus-on-the-immunological-mechanism-and-therapy-strategies-of-secondary-infection-in-sepsis
#17
(no author information available yet)
No abstract text is available yet for this article.
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29275405/neonatal-systemic-inflammation-induces-inflammatory-reactions-and-brain-apoptosis-in-a-pathogen-specific-manner
#18
Mari Falck, Damjan Osredkar, Thomas Ragnar Wood, Elke Maes, Torun Flatebø, Hemmen Sabir, Marianne Thoresen
BACKGROUND: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven treatment option. Although established as a neuroprotective therapy, benefit from HT has been questioned when infection is a comorbidity to hypoxic-ischaemic (HI) brain injury. Gram-negative and gram-positive species activate the immune system through different pathogen recognition receptors and subsequent immunological systems. In rodent models, gram-negative (lipopolysaccharide [LPS]) and gram-positive (PAM3CSK4 [PAM]) inflammation similarly increase neuronal vulnerability to HI...
2018: Neonatology
https://www.readbyqxmd.com/read/29273917/recent-advances-in-the-pathogenetic-mechanisms-of-sepsis-associated-acute-kidney-injury
#19
REVIEW
Filippo Fani, Giuseppe Regolisti, Marco Delsante, Vincenzo Cantaluppi, Giuseppe Castellano, Loreto Gesualdo, Gianluca Villa, Enrico Fiaccadori
Sepsis is a serious medical condition that can lead to multi-organ failure and shock, and it is associated with increased mortality. Acute kidney injury (AKI) is a frequent complication of sepsis in critically ill patients, and often requires renal replacement therapy. The pathophysiology of AKI in sepsis has not yet been fully defined. In the past, classic theories were mainly focused on systemic hemodynamic derangements, underscoring the key role of whole kidney hypoperfusion due to reduced renal blood flow...
December 23, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29250561/tnf-tolerance-in-monocytes-and-macrophages-characteristics-and-molecular-mechanisms
#20
REVIEW
René Huber, Rolf Bikker, Bastian Welz, Martin Christmann, Korbinian Brand
Tumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as well as induction tolerance affecting specific immunologically relevant gene sets. In this review article, we summarize the relevance of TNF tolerance in vivo and the molecular mechanisms underlying these forms of tolerance including the role of transcription factors and signaling systems...
2017: Journal of Immunology Research
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