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https://www.readbyqxmd.com/read/28078818/objectively-diagnosing-rumination-syndrome-in-children-using-esophageal-ph-impedance-and-manometry
#1
M M J Singendonk, J M Oors, A J Bredenoord, T I Omari, R J van der Pol, M J Smits, M A Benninga, M P van Wijk
BACKGROUND: Rumination syndrome is characterized by recurrent regurgitation of recently ingested food into the mouth. Differentiation with other diagnoses and gastroesophageal reflux disease (GERD) in particular, is difficult. Recently, objective pH-impedance (pH-MII) and manometry criteria were proposed for adults. The aim of this study was to determine diagnostic ambulatory pH-MII and manometry criteria for rumination syndrome in children. METHODS: Clinical data and 24-hour pH-MII and manometry recordings of children with a clinical suspicion of rumination syndrome were reviewed...
January 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28070055/superovulatory-responses-in-cynomolgus-monkeys-macaca-fascicularis-depend-on-the-interaction-between-donor-status-and-superovulation-method-used
#2
Ji-Su Kim, Seung-Bin Yoon, Kang-Jin Jeong, Bo-Woong Sim, Seon-A Choi, Sang-Il Lee, Yeung Bae Jin, Bong-Seok Song, Sang-Rae Lee, Sun-Uk Kim, Kyu-Tae Chang
The current study was performed to investigate the effect of oocyte donor status, including age and body weight, on metaphase II (MII) oocyte recovery using two superovulation methods in cynomolgus monkeys. The use of Method A [recombinant gonadotrophin (75 IU/kg, 3×, 3-day intervals) and human chorionic gonadotropin (hCG)] led to great increases in ovary size and the mean number of MII oocytes retrieved in age- and body-weight-dependent manner; in contrast, both the parameters were similar in Method B [recombinant gonadotrophin (60 IU, twice daily, 6 days), recombinant gonadotropin and recombinant human luteinizing hormone (rhLH) (60 IU, twice daily, 3 days), and hCG]...
January 9, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28069092/reduced-competence-of-immature-and-mature-oocytes-vitrified-by-cryotop-method-assessment-by-in-vitro-fertilization-and-parthenogenetic-activation-in-a-bovine-model
#3
Daiane L Bulgarelli, Alessandra A Vireque, Caroline P Pitangui-Molina, Marcos F Silva-de-Sá, Ana Carolina J de Sá Rosa-E-Silva
This study aimed to evaluate the embryo development competence, the nuclear maturation and the viability of germinal vesicle (GV) and metaphase II (MII) oocytes vitrified by the Cryotop method. Cumulus-oocyte complexes were derived from bovine ovaries and three experiments were conducted. In Experiment 1, GV oocytes were vitrified and underwent in vitro maturation (IVM) or not and their nuclear maturation was assessed by orcein staining. In Experiment 2, GV oocytes and MII oocytes were vitrified or not and the viability was assessed by calcein/ethidium homodimer-1 staining...
January 10, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28063961/zinc-supplementation-of-vitrification-medium-improves-in-vitro-maturation-and-fertilization-of-oocytes-derived-from-vitrified-warmed-mouse-ovaries
#4
Shirin Geravandi, Mehri Azadbakht, Mahsa Pourmoradi, Fatemeh Nowrouzi
Oocyte cryopreservation is an approach for fertility preservation for normal women and cancer patients facing chemo and radiotherapy. The present study evaluated the effect of adding zinc chloride to the vitrification medium used for whole mouse ovaries and then assessing the in vitro maturation and fertilization of oocytes when they were subsequently extracted from these vitrified ovarian tissues. Four vitrification solutions with 0, 100,150 and 200 μg/dl zinc (V0, V1, V2 and V3 respectively) were compared...
January 4, 2017: Cryobiology
https://www.readbyqxmd.com/read/28057448/improved-cryotolerance-and-developmental-competence-of-human-oocytes-matured-in-vitro-by-transient-hydrostatic-pressure-treatment-prior-to-vitrification
#5
Ruihuan Gu, Yun Feng, Song Guo, Shen Zhao, Xiaowei Lu, Jing Fu, Xiaoxi Sun, Yijuan Sun
BACKGROUND: At present, the metaphase II (MII) oocytes have a very special structure that leads to complex difficulties associated with its vitrification, and their efficacy still needs a large amount of study to observe. The present study was to investigate whether transient hydrostatic pressure (THP), which was utilized for oocytes before vitrification, had positive effect on the oocytes' developmental ability and reactive oxygen species, and had no damage on meiotic spindle, zona pellucida, and DNA copy number...
January 2, 2017: Cryobiology
https://www.readbyqxmd.com/read/28055144/systematic-study-of-open-shell-trigonal-pyramidal-transition-metal-complexes-with-a-rigid-ligand-scaffold
#6
Dawid Pinkowicz, Francisco Birk, Michał Magott, Kelsey Schulte, Kim Dunbar
A family of distorted trigonal pyramidal transition metal complexes [MII(N3N)Li(THF)] (M = Mn, Fe, Co, Ni) have been studied as candidates for mononuclear Single Molecule Magnetism. Magnetic anisotropy of the family depends on the electronic configuration of the central ion, with the Co analog exhibiting pronounced SMM behavior.
January 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28053142/differences-in-the-secretion-and-transport-of-wnt-proteins
#7
Shinji Takada, Sayumi Fujimori, Takuma Shinozuka, Ritsuko Takada, Yusuke Mii
During the last three decades, our understanding about Wnt signaling has progressed greatly, especially with regards to the molecular mechanism of intracellular transmission of this signaling, as well as its physiological roles. In parallel, the molecular nature of Wnt proteins has gradually but surely been clarified. Wnt proteins are post-translationaly modified with fatty acid and glycosaminoglycans, resulting in constraint of the 3D structure and behavior of the proteins. Specific binding proteins or extracellular vesicles, which appear to shield the lipid moiety from the aquatic environment, enable Wnt proteins to be transported in the extracellular space...
January 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28051267/reduced-expression-of-scf-in-serum-and-follicle-from-patients-with-polycystic-ovary-syndrome
#8
J Tan, X-Y Wen, Q Su, Z-H Huang, J-X He, C-L Xin, Q-F Wu, Y Zou
OBJECTIVE: In humans, stem cell factor (SCF), produced by cumulus granulosa cells during the follicular phase, plays a crucial role in follicular development. Remarkably, polycystic ovary syndrome (PCOS), one of the main reasons affecting women fertility, is accompanied by some abnormal follicles. Is there a relationship between SCF and PCOS? This study aimed to compare the expression of SCF in follicle and serum from patients with and without PCOS undergoing in vitro fertilization (IVF) treatment and to investigate the potential relationship between aberrant SCF expression and PCOS...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28050963/live-births-after-polar-body-biopsy-and-frozen-thawed-cleavage-stage-embryo-transfer-case-report
#9
Fernando Guimarães, Matheus Roque, Marcello Valle, Alessandra Kostolias, Rodrigo A de Azevedo, Ciro D Martinhago, Marcos Sampaio, Selmo Geber
Pre-implantation genetic diagnosis (PGD) or screening (PGS) technology, has emerged and developed in the past few years, benefiting couples as it allows the selection and transfer of healthy embryos during IVF treatments. These techniques can be performed in oocytes (polar-body biopsy) or embryos (blastomere or trophectoderm biopsy). In this case report, we describe the first two live births to be published in Brazil after a polar-body (PB) biopsy. In case 1, a 42-year-old was submitted to PB biopsy with PGS due to advanced maternal age and poor ovarian reserve...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28044052/the-relationship-of-the-post-reflux-swallow-induced-peristaltic-wave-index-and-esophageal-baseline-impedance-with-gastroesophageal-reflux-disease-symptoms
#10
Young Kyu Cho, Joon Seong Lee, Tae Hee Lee, Su Jin Hong, Sang Joon Park, Seong Ran Jeon, Hyun Gun Kim, Jin-Oh Kim
Background/Aims: The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with reflux symptoms is not known. We aimed to evaluate the correlations of the PSPW index and esophageal BI with gastroesophageal reflux disease (GERD) symptoms. Methods: We performed a retrospective review of multichannel intraluminal impedance and pH (MII-pH) tracings in patients with suspected GERD...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28043375/comparative-dynamics-of-5-methylcytosine-reprogramming-and-tet-family-expression-during-preimplantation-mammalian-development-in-mouse-and-sheep
#11
F Jafarpour, S M Hosseini, S Ostadhosseini, H Abbasi, A Dalman, M H Nasr-Esfahani
Despite previous assumption that paternal active DNA demethylation is an evolutionary conserved phenomenon in mammals, emerging studies in other species, particularly sheep, do not support this issue. Recently, ten eleven translocation (TET) enzymes have been suggested as intermediates in genome-wide DNA demethylation through the iterative conversion of five methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC)/5-formylcytosine/5-carboxylcytosine (5caC) derivatives. This study investigated whether TET enzymes and 5mC derivatives are also involved in dynamic reprogramming of early sheep embryos derived by fertilization...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28042535/effects-of-mono-2-ethylhexyl-phthalate-and-di-2-ethylhexyl-phthalate-administrations-on-oocyte-meiotic-maturation-apoptosis-and-gene-quantification-in-mouse-model
#12
Forouzan Absalan, Sadegh Saremy, Esrafil Mansori, Mahin Taheri Moghadam, Ali Reza Eftekhari Moghadam, Razie Ghanavati
OBJECTIVE: Phthalates, which are commonly used to render plastics into soft and flexible materials, have also been determined as developmental and reproductive toxicants in human and animals. The purpose of this study was to evaluate the effect of mono-(2- ethylhexyl) phthalate (MEHP) and di-(2-ethylhexyl) phthalate (DEHP) oral administrations on maturation of mouse oocytes, apoptosis and gene transcription levels. MATERIALS AND METHODS: In this experimental study, immature oocytes recovered from Naval Medical Research Institute (NMRI) mouse strain (6-8 weeks), were divided into seven different experimental and control groups...
2017: Cell Journal
https://www.readbyqxmd.com/read/28040122/vitrification-of-mouse-mii-oocytes-developmental-competency-using-paclitaxel
#13
Farzaneh Fesahat, Azita Faramarzi, Arezoo Khoradmehr, Marjan Omidi, Fatemeh Anbari, Mohammad Ali Khalili
OBJECTIVE: Oocyte cryopreservation provides an important alternative for fertility preservation for women who will be treated with cytotoxic drugs. However, it can cause spindle disorganization of microtubules, putting the zygote at risk for aneuploidy. Paclitaxel is known to stabilize the microtubules that constitute the spindle. The aim of this study was to investigate the suitable concentration of paclitaxel for adding to the vitrification media to improve the developmental potential of post-thawed mature oocytes to blastocyst formation in mice...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28039065/microrna-224-delays-oocyte-maturation-through-targeting-ptx3-in-cumulus-cells
#14
Xiufang Li, Huidan Wang, Yan Sheng, Zhongqing Wang
MicroRNAs (miRNAs) have been improved to regulate oocyte development in a cell- or stage-specific manner. In this study, we aimed to clarify microRNA-224's (miR-224) role in cumulus cells (CCs), to find out whether a change level of miR-224 in CCs could influence the maturation of oocyte. We found that overexpression of miR-224 of CCs led to the impairment of cell expansion, along with a decrease in the gene expression associated with cell expansion and maturation of oocyte. The increased expression of miR-224 in CC interrupted oocyte cell cycle at the GV stage...
December 28, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/28029348/ethnic-identity-and-paranoid-thinking-implicit-out-group-preference-and-language-dominance-predict-paranoia-in-emirati-women
#15
Justin Thomas, Richard P Bentall, Lowri Hadden, Lily O'Hara
BACKGROUND AND OBJECTIVES: Psychotic experiences including persecutory beliefs are elevated among immigrant and minority populations, especially when living in low ethnic density neighbourhoods (the ethnic density effect). Discrimination, victimization and experiencing a sense of 'not belonging' are hypothesized to play a role in this effect. Because a secure ethnic identity protects against poor self-esteem it may also protect against paranoia. This study explores the relationship between language proficiency (Arabic/English), in-group identity (implicit and explicit) and paranoia in female Emirati university students...
October 24, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28029191/beauty-in-the-breakdown-morphology-of-the-first-polar-body-in-mature-mouse-eggs
#16
Allison R Grover, Dana Kimelman, Megan A Runge, Francesca E Duncan
In vitro maturation (IVM) is the process whereby oocytes arrested in prophase of meiosis I are stimulated to resume meiosis and progress to metaphase of meiosis II (MII) ex vivo. Here we examined the cytoskeletal morphology of mature MII eggs obtained following IVM. Cumulus oocyte complexes were isolated from antral follicles of hyper-stimulated female mice, and cumulus cells were removed to induce spontaneous oocyte meiotic maturation. This article is protected by copyright. All rights reserved.
December 28, 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28028956/assessment-of-clinical-symptoms-and-multichannel-intraluminal-impedance-and-ph-monitoring-in-children-after-thoracoscopic-repair-of-esophageal-atresia-and-distal-tracheoesophageal-fistula
#17
Barbara M Iwańczak, Agnieszka Kosmowska-Miśków, Anna Kofla-Dłubacz, Mateusz Palczewski, Michał Grabiński, Katarzyna Pawłowska, Krzysztof Matusiewicz, Dariusz Patkowski
BACKGROUND: Motility disturbances of the esophagus and gastroesophageal reflux disease (GERD) are observed frequently in children after repair of congenital esophageal atresia with distal tracheoesophageal fistula (EA/TEF). Recently, in many pediatric surgical centers, thoracoscopic repair was introduced, which theoretically would change the postoperative course. OBJECTIVES: The goal of the study was to assess physical development, disease symptoms, and GERD symptom frequency in children who underwent thoracoscopic surgery of congenital EA/TEF...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028772/hydroxypropyl-cellulose-supplementation-in-vitrification-solutions-a-prospective-study-with-donor-oocytes
#18
Miguel Gallardo, María Hebles, Beatriz Migueles, Mónica Dorado, Laura Aguilera, Mercedes González, Paloma Piqueras, Alejandro Lucas, Lorena Montero, Pascual Sánchez-Martín, Fernando Sánchez-Martín, Ramón Risco
PURPOSE: Hydroxypropyl cellulose (HPC), a polysaccharide that forms a viscous gel under low temperatures, is a promising substitute of the blood-derived macromolecules traditionally used in cryopreservation solutions. The performance of a protein-free, fully synthetic set of vitrification and warming solutions was assessed in a matched pair analysis with donor oocytes. METHODS: A prospective study including 219 donor MII oocytes was carried out, comparing the laboratory outcomes of oocytes vitrified with HPC-based solutions and their fresh counterparts...
December 27, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28025854/changes-in-acetylation-of-lysine-5-on-histone-h4-in-canine-oocytes-following-in-vitro-maturation
#19
T F Motheo, D R Arnold, L C Padilha-Nakaghi, E A Pires-Buttler, A E Alves, M Apparicio, Wrr Vicente, F L Lopes
Post-translational modifications of histones, such as acetylation, are involved in regulating chromatin remodelling and gene expression. Proper in vitro maturation (IVM) of canine oocytes, for many reasons, is up to now inefficient. This study aimed to evaluate the post-translational histone H4 acetylation at lysine 5 (H4K5) in immature and post-IVM canine oocytes. Oocyte nuclear stage was assessed using Hoechst 33342 staining. Acetylation patterns were determined by indirect immunofluorescence staining of immature and post-IVM oocytes, using an antibody against the acetylated lysine 5 residue on histone 4 (H4K5ac)...
December 27, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28024403/genetic-algorithm-managed-peptide-mutant-screening-optimizing-peptide-ligands-for-targeted-receptor-binding
#20
Matthew D King, Thomas Long, Timothy Andersen, Owen M McDougal
This study demonstrates the utility of genetic algorithms to search exceptionally large and otherwise intractable mutant libraries for sequences with optimal binding affinities for target receptors. The Genetic Algorithm Managed Peptide Mutant Screening (GAMPMS) program was used to search an α-conotoxin (α-CTx) MII mutant library of approximately 41 billion possible peptide sequences for those exhibiting the greatest binding affinity for the α3β2-nicotinic acetylcholine receptor (nAChR) isoform. A series of top resulting peptide ligands with high sequence homology was obtained, with each mutant having an estimated ΔGbind approximately double that of the potent native α-CTx MII ligand...
December 27, 2016: Journal of Chemical Information and Modeling
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