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https://www.readbyqxmd.com/read/27858347/serum-concentrations-of-mood-stabilizers-are-associated-with-memory-but-not-other-cognitive-domains-in-psychosis-spectrum-disorders-explorative-analyses-in-a-naturalistic-setting
#1
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27816324/differences-in-clinical-presentation-between-bipolar-i-and-ii-disorders-in-the-early-stages-of-bipolar-disorder-a-naturalistic-study
#2
Maj Vinberg, Rie Lambaek Mikkelsen, Thomas Kirkegaard, Ellen Margrethe Christensen, Lars Vedel Kessing
AIM: In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional level, the presence of comorbid personality disorders and coping strategies. METHODS: Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders...
October 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27794253/trajectories-of-body-mass-index-change-in-first-episode-of-mania-3-year-data-from-the-systematic-treatment-optimization-program-for-early-mania-stop-em
#3
Chen Hu, Ivan J Torres, Hong Qian, Hubert Wong, Priyanka Halli, Taj Dhanoa, Sharon Ahn, Gang Wang, David J Bond, Raymond W Lam, Lakshmi N Yatham
BACKGROUND: Overweight/obesity is common in patients with bipolar disorder (BD). However, little is known about longitudinal trends in body mass index (BMI) in patients with BD. Furthermore, most studies on the association between BMI and clinical outcomes are restricted by retrospective and cross-sectional designs. This study uses prospectively-gathered data from a first episode mania (FEM) cohort to examine the trajectories of BMI change and analyze their association with clinical outcomes during a 3-year period...
October 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27624425/contribution-of-long-duration-of-undiagnosed-bipolar-disorder-to-high-frequency-of-relapse-a-naturalistic-study-in-china
#4
Wu Hong, Chen Zhang, Meng Juan Xing, Dai Hui Peng, Zhi Guo Wu, Zuo Wei Wang, Jun Chen, Cheng Mei Yuan, You Song Su, Ying Yan Hu, Lan Cao, Yong Wang, Jia Huang, Wei Hong Lu, Zheng Hui Yi, Xin Yu, Jing Ping Zhao, Qinting Zhang, Yi Ru Fang
BACKGROUND: With attention to misdiagnosis of bipolar disorder (BP), long duration of undiagnosed bipolar disorder (DUBP) had been reported recently in years. This study aims to investigate the contributions of long DUBP to the frequency of relapse in bipolar patients, and explore affect factors of DUBP. METHOD: From 26 hospitals throughout China, 3896 participants diagnosed with BP according to International Classification of Diseases 10th criteria were enrolled in this study...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27621637/suicidality-and-symptoms-of-anxiety-irritability-and-agitation-in-patients-experiencing-manic-episodes-with-depressive-symptoms-a-naturalistic-study
#5
Jonas Eberhard, Emmanuelle Weiller
PURPOSE: Patients with a bipolar I disorder (BD-I) manic episode meeting the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria for "with mixed features" have a high incidence of suicide attempts and of anxiety, irritability, and agitation (AIA) symptoms. The aim of this analysis was to explore the relationship between suicidality and AIA symptoms in patients with BD-I experiencing mania with depressive symptoms, using data from a previous naturalistic study...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27434490/voice-analysis-as-an-objective-state-marker-in-bipolar-disorder
#6
M Faurholt-Jepsen, J Busk, M Frost, M Vinberg, E M Christensen, O Winther, J E Bardram, L V Kessing
Changes in speech have been suggested as sensitive and valid measures of depression and mania in bipolar disorder. The present study aimed at investigating (1) voice features collected during phone calls as objective markers of affective states in bipolar disorder and (2) if combining voice features with automatically generated objective smartphone data on behavioral activities (for example, number of text messages and phone calls per day) and electronic self-monitored data (mood) on illness activity would increase the accuracy as a marker of affective states...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27335515/a-cross-sectional-comparative-study-of-insight-in-schizophrenia-and-bipolar-patients-in-remission
#7
Arul Saravanan Ramachandran, Rajkumar Ramanathan, Samir Kumar Praharaj, Haridas Kanradi, Podila Satya Venkata Narasimha Sharma
AIMS: To study insight correlates in schizophrenia and bipolar mood disorder in remission among out-patients attending the Psychiatry Department of a Tertiary Care Hospital. SETTINGS AND DESIGN: In a cross-sectional, naturalistic study, adult patients with schizophrenia and bipolar mood disorder in remission (n = 80; schizophrenia-40, mania-20, bipolar depression-20) were compared on insight measures and clinical correlates. MATERIALS AND METHODS: Scale to Assess the Unawareness of Mental Disorders (SUMD) was used as the main tool to assess current and past measures of insight...
May 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27079133/mixed-depression-in-bipolar-disorder-prevalence-rate-and-clinical-correlates-during-naturalistic-follow-up-in-the-stanley-bipolar-network
#8
Shefali Miller, Trisha Suppes, Jim Mintz, Gerhard Hellemann, Mark A Frye, Susan L McElroy, Willem A Nolen, Ralph Kupka, Gabriele S Leverich, Heinz Grunze, Lori L Altshuler, Paul E Keck, Robert M Post
OBJECTIVE: DSM-5 introduced the "with mixed features" specifier for major depressive episodes. The authors assessed the prevalence and phenomenology of mixed depression among bipolar disorder patients and qualitatively compared a range of diagnostic thresholds for mixed depression. METHOD: In a naturalistic study, 907 adult outpatients with bipolar disorder participating in the Stanley Foundation Bipolar Network were followed longitudinally across 14,310 visits from 1995 to 2002...
April 15, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27071831/increased-sleep-duration-precedes-the-improvement-of-other-symptom-domains-during-the-treatment-of-acute-mania-a-retrospective-chart-review
#9
Igor I Galynker, Zimri S Yaseen, Siva S Koppolu, Barney Vaughan, Magdalena Szklarska-Imiolek, Lisa J Cohen, Thomas M Salvanti, Hae-Joon Kim
BACKGROUND: Understanding trajectories of symptom changes may help gauge treatment response and better identify therapeutic targets in treatment of acute mania. We examined how symptoms of sleep disturbance, mania, and psychosis resolved in a naturalistic treatment setting, hypothesizing that improvement in sleep would precede improvement in manic and psychotic symptoms. METHODS: Charts of 100 patients with admitting diagnoses of bipolar mixed or manic episode were retrospectively reviewed...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/26805563/platelet-parameters-plt-mpv-p-lcr-in-patients-with-schizophrenia-unipolar-depression-and-bipolar-disorder
#10
Adam Wysokiński, Ewa Szczepocka
There are no studies comparing platelet parameters platelet parameters (platelet count (PLT), mean platelet volume (MPV) and platelet large cell ratio (P-LCR)) between patients with schizophrenia, bipolar disorder and unipolar depression. Therefore, the aim of this study was to determine and compare differences in PLT, MPV and P-LCR in patients with schizophrenia, unipolar depression and bipolar disorder. This was a retrospective, cross-sectional, naturalistic study of 2377 patients (schizophrenia n=1243; unipolar depression n=791; bipolar disorder n=343, including bipolar depression n=259 and mania n=84)...
March 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26717522/are-manic-symptoms-that-dip-into-depression-the-essence-of-mixed-features
#11
Gin S Malhi, Kristina Fritz, Christine Allwang, Nicole Burston, Chris Cocks, Jill Devlin, Margaret Harper, Ben Hoadley, Brian Kearney, Peter Klug, Linton Meagher, Mark Rowe, Hany Samir, Raymond Way, Craig Wilson, William Lyndon
BACKGROUND: Three symptoms of (hypo)mania that clinically represent mood disorders mixed states have been omitted from the DSM-5 mixed features specifier because 'they fail to discriminate between manic and depressive syndromes'. Therefore, the present study examined the role of distractibility, irritability and psychomotor agitation (DIP) in characterising mixed depressive states. METHODS: Fifty in-patients at a specialist mood disorders unit underwent a detailed longitudinal clinical evaluation (3-6 weeks) and were assessed on a range of standardized measures to characterise their illness according to depression subtype, duration of illness and clinical features-including specifically depressive and manic symptoms and the context in which these occur...
March 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26455693/what-happens-now-the-importance-of-naturalistic-course-after-first-mania
#12
COMMENT
Andrew A Nierenberg, Louisa G Sylvia, Kristen K Ellard, Sharmin Ghaznavi, Thilo Deckersbach
No abstract text is available yet for this article.
September 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26288263/omega-3-supplementation-for-psychotic-mania-and-comorbid-anxiety-in-children
#13
REVIEW
Anthony T Vesco, Jennifer Lehmann, Barbara L Gracious, L Eugene Arnold, Andrea S Young, Mary A Fristad
OBJECTIVES: Therapeutic benefits of omega-3 fatty acids (Ω3) for mood disorders, psychosis, and anxiety have been reported in the literature. The purpose of the present article is to provide a literature review of Ω3 supplementation for affective disorders and to illustrate the benefits of Ω3 with a case presentation of a young girl with a history of bipolar disorder-type 1 with psychotic features and generalized anxiety disorder. METHODS: Reviewed literature includes treatment studies of the impact of Ω3 on child mood disorders supplemented by review of meta-analyses within the adult mood disorders literature...
September 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25995638/evaluating-depressive-symptoms-in-mania-a-naturalistic-study-of-patients-with-bipolar-disorder
#14
Allan H Young, Jonas Eberhard
OBJECTIVE: This study aimed to evaluate patients with bipolar I disorder (BD-I) who have mania with depressive symptoms and who meet the new "with mixed features" specifier of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). METHOD: This prospective, multinational, naturalistic study surveyed psychiatrists and their patients with BD-I from October 2013 to March 2014. Eligible patients had BD-I, had a (current) manic episode, and had experienced onset of a manic episode within the previous 3 months...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25943979/making-sense-of-dsm-5-mania-with-depressive-features
#15
MULTICENTER STUDY
María Reinares, Caterina del Mar Bonnín, Diego Hidalgo-Mazzei, Juan Undurraga, Maria Mur, Evaristo Nieto, Cristina Sáez, Eduard Vieta
OBJECTIVE: The assessment of the depressive component during mania has become critical for the accurate diagnosis of mixed states, which were defined very narrowly in the past classification systems before Diagnostic and Statistical Manual of Mental Disorders (5th ed.). The aim of this study was to compare socio-demographic, clinical and therapeutic characteristics, as well as clinical and functional outcomes, between manic patients with and without mixed features to validate the relevance of the Diagnostic and Statistical Manual of Mental Disorders (5th ed...
June 2015: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/25709459/the-noradrenaline-metabolite-mhpg-is-a-candidate-biomarker-between-the-depressive-remission-and-manic-states-in-bipolar-disorder-i-two-long-term-naturalistic-case-reports
#16
Masatake Kurita, Satoshi Nishino, Yukio Numata, Yoshiro Okubo, Tadahiro Sato
BACKGROUND: Treatment of the depressive and manic states in bipolar disorder I (BDI) is a challenge for psychiatrists. Despite the recognized importance of the switch phenomenon, the precise mechanisms underlying this process are yet to be shown. We conducted a naturalistic study in two BDI patients to determine whether biological markers (monoamine metabolites and brain-derived neurotrophic factor [BDNF]) are associated with the switch between depressive and manic states. CASE PRESENTATION AND METHODS: Blood sampling and mood assessments were performed at 2-week intervals over a period of 2 (Case 1, n=72) and 6 (Case 2, n=183) years...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/25670662/clinical-characteristics-of-patients-with-late-life-bipolar-disorder-in-the-community-data-from-the-nndc-registry
#17
MULTICENTER STUDY
Brent P Forester, Olu Ajilore, Cathie Spino, Susan W Lehmann
OBJECTIVE: To compare clinical characteristics of older and younger patients with bipolar disorder enrolled in the United States' National Network of Depression Centers (NNDC) Clinical Care Registry (CCR). DESIGN: Multicenter, de-identified naturalistic data from the National NNDC's CCR for all patients with a diagnosis of bipolar disorder who were enrolled in the registry as of April 25, 2013. PARTICIPANTS: Community-dwelling patients (N = 218), ages 18 years or older, with bipolar disorder diagnosis recruited by NNDC-affiliated medical centers to participate in the NNDC CCR...
September 2015: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/25650685/three-year-naturalistic-mirror-image-assessment-of-adding-memantine-to-the-treatment-of-30-treatment-resistant-patients-with-bipolar-disorder
#18
Giulia Serra, Athanasios Koukopoulos, Lavinia De Chiara, Alexia E Koukopoulos, Leonardo Tondo, Paolo Girardi, Ross J Baldessarini, Gino Serra
BACKGROUND: Developing safe and effective long-term treatments for bipolar disorder remains a major challenge. Given available treatments, patients with bipolar disorder remain unwell in half of long-term follow-up, mostly in depression. As memantine, an N-methyl-D-aspartate (NMDA)-glutamate receptor antagonist used to treat dementia, has been proposed for testing in bipolar disorder, we carried out a 3 + 3-year, mirror-image, chart-review study of the effects of adding memantine to stably continued, but insufficiently effective, ongoing mood-stabilizing treatments...
January 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/25540723/memantine-new-prospective-in-bipolar-disorder-treatment
#19
REVIEW
Giulia Serra, Francesca Demontis, Francesca Serra, Lavinia De Chiara, Andrea Spoto, Paolo Girardi, Giulio Vidotto, Gino Serra
UNLABELLED: We review preclinical and clinical evidences strongly suggesting that memantine, an old drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania and for the prevention of manic/hypomanic and depressive recurrences of manic-depressive illness. Lithium remains the first line for the treatment and prophylaxis of bipolar disorders, but currently available treatment alternatives for lithium resistant patients are of limited and/or questionable efficacy...
December 22, 2014: World Journal of Psychiatry
https://www.readbyqxmd.com/read/25419134/a-prospective-naturalistic-study-of-antidepressant-induced-jitteriness-anxiety-syndrome
#20
Tsuyoto Harada, Ken Inada, Kazuo Yamada, Kaoru Sakamoto, Jun Ishigooka
OBJECTIVE: Patients often develop neuropsychiatric symptoms such as anxiety and agitation after they have started taking an antidepressant, and this is thought to be associated with a potentially increased risk of suicide. However, the incidence of antidepressant-induced jitteriness/anxiety syndrome has not been fully investigated, and little has been reported on its predictors. The aim of this study was to survey the incidence of antidepressant-induced jitteriness/anxiety syndrome and clarify its predictors in a natural clinical setting...
2014: Neuropsychiatric Disease and Treatment
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