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https://www.readbyqxmd.com/read/28918761/quality-of-life-in-bipolar-disorder-towards-a-dynamic-understanding
#1
E Morton, G Murray, E E Michalak, R W Lam, S Beaulieu, V Sharma, P Cervantes, S V Parikh, L N Yatham
BACKGROUND: Although quality of life (QoL) is receiving increasing attention in bipolar disorder (BD) research and practice, little is known about its naturalistic trajectory. The dual aims of this study were to prospectively investigate: (a) the trajectory of QoL under guideline-driven treatment and (b) the dynamic relationship between mood symptoms and QoL. METHODS: In total, 362 patients with BD receiving guideline-driven treatment were prospectively followed at 3-month intervals for up to 5 years...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28817765/preventive-effects-of-lamotrigine-in-bipolar-ii-versus-bipolar-i-disorder
#2
Takeshi Terao, Atsuko Ishida, Toshifumi Kimura, Masao Yarita, Terufumi Hara
OBJECTIVE: The preventive effects of mood stabilizers on recurrence/relapse in bipolar disorders have been investigated mostly in bipolar I disorder (BPI) patients, with limited reports on bipolar II disorder (BPII) patients. Here, we conducted an explorative data analysis to investigate whether the preventive effect of lamotrigine on recurrence /relapse in BPII is better than in BPI. METHODS: Data from Japanese patients with a diagnosis of BPI or BPII according to DSM-IV-TR were analyzed in an open-label, noninterventional, naturalistic, prospective postmarketing surveillance study of lamotrigine...
August 15, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28753472/longitudinal-mood-monitoring-in-bipolar-disorder-course-of-illness-as-revealed-through-a-short-messaging-service
#3
Rebecca F McKnight, Amy C Bilderbeck, David J Miklowitz, Christopher Hinds, Guy M Goodwin, John R Geddes
BACKGROUND: Online self-monitoring of mood can be used to investigate differences in course patterns across patient groups. This study explored the feasibility of remote symptom capture with True Colours, a self-rated online mood monitoring tool completed on a weekly basis. METHODS: Participants with bipolar disorder (N = 297) completed weekly depression and mania questionnaires over an average of 27.5 months (range 1 -81 months). Subgroups defined by sex, age, and bipolar I vs...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28665044/mood-symptoms-in-pregnant-and-postpartum-women-with-bipolar-disorder-a-naturalistic-study
#4
Kara E Driscoll, Dorothy K Y Sit, Eydie L Moses-Kolko, Emily Pinheiro, Amy Yang, Jody D Ciolino, Heather F Eng, James F Luther, Crystal T Clark, Stephen R Wisniewski, Katherine L Wisner
OBJECTIVE: We conducted a prospective naturalistic study of pregnant women with bipolar disorder (BD) to evaluate symptoms of BD across childbearing and assess whether pharmacotherapy reduced their severity. METHODS: Assessments were scheduled at 20, 30, and 36 weeks' gestation and 2, 12, 26, and 52 weeks postpartum. Symptoms were assessed using the Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Supplement (SIGH-ADS) and Mania Rating Scale (MRS)...
June 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28590370/early-improvement-predicts-treatment-outcomes-for-patients-with-acute-mania-a-naturalistic-study-in-taiwan
#5
Dian-Jeng Li, Ching-Hua Lin, Mei-Jou Lu
BACKGROUND: Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS: We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Symptom severity was assessed using the Young Mania Rating Scale (YMRS) at weeks 0, 1, 2, 3, and 4. Early improvement was defined as a reduction in the YMRS score of at least 20% or 25%, assessed at weeks 1 and 2...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28470892/impact-of-irritability-a-2-year-observational-study-of-outpatients-with-bipolar-i-or-schizoaffective-disorder
#6
Lesley Berk, Karen T Hallam, Kamalesh Venugopal, Andrew James Lewis, David W Austin, Jayashri Kulkarni, Seetal Dodd, Anthony de Castella, Paul B Fitzgerald, Michael Berk
OBJECTIVES: Many people experience irritability when manic, hypomanic, or depressed, yet its impact on illness severity and quality of life in bipolar and schizoaffective disorders is poorly understood. This study aimed to examine the relationship between irritability and symptom burden, functioning, quality of life, social support, suicidality, and overall illness severity in a naturalistic cohort of people with bipolar I or schizoaffective disorder. METHODS: We used data from 239 adult outpatients with bipolar I or schizoaffective disorder in the Bipolar Comprehensive Outcomes Study (BCOS) - a non-interventional observational study with a 2-year follow-up period...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28255436/does-the-efficacy-of-asenapine-in-bipolar-disorder-increase-in-the-presence-of-comorbidity-with-a-substance-use-disorder-a-naturalistic-study
#7
Sergio De Filippis, Ilaria Cuomo, Georgios D Kotzalidis, Daniela Pucci, Pietro Zingaretti, Raffaella Porrari, Camilla Fini, Paola Motta, Matteo Caloro, Paolo Girardi
BACKGROUND: Asenapine is a second-generation antipsychotic approved in Europe for treating moderate-to-severe manic episodes in adults affected by type I bipolar disorder (BD-I). We aimed to compare its efficacy in psychiatric inpatients with BD-I, with or without substance use disorder (SUD). METHODS: We administered flexible asenapine doses ranging from 5-20 mg/day to 119 voluntarily hospitalized patients with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) BD-I diagnosis, with or without SUD...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27858347/serum-concentrations-of-mood-stabilizers-are-associated-with-memory-but-not-other-cognitive-domains-in-psychosis-spectrum-disorders-explorative-analyses-in-a-naturalistic-setting
#8
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27816324/differences-in-clinical-presentation-between-bipolar-i-and-ii-disorders-in-the-early-stages-of-bipolar-disorder-a-naturalistic-study
#9
Maj Vinberg, Rie Lambaek Mikkelsen, Thomas Kirkegaard, Ellen Margrethe Christensen, Lars Vedel Kessing
AIM: In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional level, the presence of comorbid personality disorders and coping strategies. METHODS: Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27794253/trajectories-of-body-mass-index-change-in-first-episode-of-mania-3-year-data-from-the-systematic-treatment-optimization-program-for-early-mania-stop-em
#10
Chen Hu, Ivan J Torres, Hong Qian, Hubert Wong, Priyanka Halli, Taj Dhanoa, Sharon Ahn, Gang Wang, David J Bond, Raymond W Lam, Lakshmi N Yatham
BACKGROUND: Overweight/obesity is common in patients with bipolar disorder (BD). However, little is known about longitudinal trends in body mass index (BMI) in patients with BD. Furthermore, most studies on the association between BMI and clinical outcomes are restricted by retrospective and cross-sectional designs. This study uses prospectively-gathered data from a first episode mania (FEM) cohort to examine the trajectories of BMI change and analyze their association with clinical outcomes during a 3-year period...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27624425/contribution-of-long-duration-of-undiagnosed-bipolar-disorder-to-high-frequency-of-relapse-a-naturalistic-study-in-china
#11
MULTICENTER STUDY
Wu Hong, Chen Zhang, Meng Juan Xing, Dai Hui Peng, Zhi Guo Wu, Zuo Wei Wang, Jun Chen, Cheng Mei Yuan, You Song Su, Ying Yan Hu, Lan Cao, Yong Wang, Jia Huang, Wei Hong Lu, Zheng Hui Yi, Xin Yu, Jing Ping Zhao, Qinting Zhang, Yi Ru Fang
BACKGROUND: With attention to misdiagnosis of bipolar disorder (BP), long duration of undiagnosed bipolar disorder (DUBP) had been reported recently in years. This study aims to investigate the contributions of long DUBP to the frequency of relapse in bipolar patients, and explore affect factors of DUBP. METHOD: From 26 hospitals throughout China, 3896 participants diagnosed with BP according to International Classification of Diseases 10th criteria were enrolled in this study...
October 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27621637/suicidality-and-symptoms-of-anxiety-irritability-and-agitation-in-patients-experiencing-manic-episodes-with-depressive-symptoms-a-naturalistic-study
#12
Jonas Eberhard, Emmanuelle Weiller
PURPOSE: Patients with a bipolar I disorder (BD-I) manic episode meeting the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria for "with mixed features" have a high incidence of suicide attempts and of anxiety, irritability, and agitation (AIA) symptoms. The aim of this analysis was to explore the relationship between suicidality and AIA symptoms in patients with BD-I experiencing mania with depressive symptoms, using data from a previous naturalistic study...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27434490/voice-analysis-as-an-objective-state-marker-in-bipolar-disorder
#13
M Faurholt-Jepsen, J Busk, M Frost, M Vinberg, E M Christensen, O Winther, J E Bardram, L V Kessing
Changes in speech have been suggested as sensitive and valid measures of depression and mania in bipolar disorder. The present study aimed at investigating (1) voice features collected during phone calls as objective markers of affective states in bipolar disorder and (2) if combining voice features with automatically generated objective smartphone data on behavioral activities (for example, number of text messages and phone calls per day) and electronic self-monitored data (mood) on illness activity would increase the accuracy as a marker of affective states...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27335515/a-cross-sectional-comparative-study-of-insight-in-schizophrenia-and-bipolar-patients-in-remission
#14
Arul Saravanan Ramachandran, Rajkumar Ramanathan, Samir Kumar Praharaj, Haridas Kanradi, Podila Satya Venkata Narasimha Sharma
AIMS: To study insight correlates in schizophrenia and bipolar mood disorder in remission among out-patients attending the Psychiatry Department of a Tertiary Care Hospital. SETTINGS AND DESIGN: In a cross-sectional, naturalistic study, adult patients with schizophrenia and bipolar mood disorder in remission (n = 80; schizophrenia-40, mania-20, bipolar depression-20) were compared on insight measures and clinical correlates. MATERIALS AND METHODS: Scale to Assess the Unawareness of Mental Disorders (SUMD) was used as the main tool to assess current and past measures of insight...
May 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27079133/mixed-depression-in-bipolar-disorder-prevalence-rate-and-clinical-correlates-during-naturalistic-follow-up-in-the-stanley-bipolar-network
#15
MULTICENTER STUDY
Shefali Miller, Trisha Suppes, Jim Mintz, Gerhard Hellemann, Mark A Frye, Susan L McElroy, Willem A Nolen, Ralph Kupka, Gabriele S Leverich, Heinz Grunze, Lori L Altshuler, Paul E Keck, Robert M Post
OBJECTIVE: DSM-5 introduced the "with mixed features" specifier for major depressive episodes. The authors assessed the prevalence and phenomenology of mixed depression among bipolar disorder patients and qualitatively compared a range of diagnostic thresholds for mixed depression. METHOD: In a naturalistic study, 907 adult outpatients with bipolar disorder participating in the Stanley Foundation Bipolar Network were followed longitudinally across 14,310 visits from 1995 to 2002...
October 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27071831/increased-sleep-duration-precedes-the-improvement-of-other-symptom-domains-during-the-treatment-of-acute-mania-a-retrospective-chart-review
#16
Igor I Galynker, Zimri S Yaseen, Siva S Koppolu, Barney Vaughan, Magdalena Szklarska-Imiolek, Lisa J Cohen, Thomas M Salvanti, Hae-Joon Kim
BACKGROUND: Understanding trajectories of symptom changes may help gauge treatment response and better identify therapeutic targets in treatment of acute mania. We examined how symptoms of sleep disturbance, mania, and psychosis resolved in a naturalistic treatment setting, hypothesizing that improvement in sleep would precede improvement in manic and psychotic symptoms. METHODS: Charts of 100 patients with admitting diagnoses of bipolar mixed or manic episode were retrospectively reviewed...
April 12, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/26805563/platelet-parameters-plt-mpv-p-lcr-in-patients-with-schizophrenia-unipolar-depression-and-bipolar-disorder
#17
Adam Wysokiński, Ewa Szczepocka
There are no studies comparing platelet parameters platelet parameters (platelet count (PLT), mean platelet volume (MPV) and platelet large cell ratio (P-LCR)) between patients with schizophrenia, bipolar disorder and unipolar depression. Therefore, the aim of this study was to determine and compare differences in PLT, MPV and P-LCR in patients with schizophrenia, unipolar depression and bipolar disorder. This was a retrospective, cross-sectional, naturalistic study of 2377 patients (schizophrenia n=1243; unipolar depression n=791; bipolar disorder n=343, including bipolar depression n=259 and mania n=84)...
March 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26717522/are-manic-symptoms-that-dip-into-depression-the-essence-of-mixed-features
#18
Gin S Malhi, Kristina Fritz, Christine Allwang, Nicole Burston, Chris Cocks, Jill Devlin, Margaret Harper, Ben Hoadley, Brian Kearney, Peter Klug, Linton Meagher, Mark Rowe, Hany Samir, Raymond Way, Craig Wilson, William Lyndon
BACKGROUND: Three symptoms of (hypo)mania that clinically represent mood disorders mixed states have been omitted from the DSM-5 mixed features specifier because 'they fail to discriminate between manic and depressive syndromes'. Therefore, the present study examined the role of distractibility, irritability and psychomotor agitation (DIP) in characterising mixed depressive states. METHODS: Fifty in-patients at a specialist mood disorders unit underwent a detailed longitudinal clinical evaluation (3-6 weeks) and were assessed on a range of standardized measures to characterise their illness according to depression subtype, duration of illness and clinical features-including specifically depressive and manic symptoms and the context in which these occur...
March 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26455693/what-happens-now-the-importance-of-naturalistic-course-after-first-mania
#19
COMMENT
Andrew A Nierenberg, Louisa G Sylvia, Kristen K Ellard, Sharmin Ghaznavi, Thilo Deckersbach
No abstract text is available yet for this article.
September 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26288263/omega-3-supplementation-for-psychotic-mania-and-comorbid-anxiety-in-children
#20
REVIEW
Anthony T Vesco, Jennifer Lehmann, Barbara L Gracious, L Eugene Arnold, Andrea S Young, Mary A Fristad
OBJECTIVES: Therapeutic benefits of omega-3 fatty acids (Ω3) for mood disorders, psychosis, and anxiety have been reported in the literature. The purpose of the present article is to provide a literature review of Ω3 supplementation for affective disorders and to illustrate the benefits of Ω3 with a case presentation of a young girl with a history of bipolar disorder-type 1 with psychotic features and generalized anxiety disorder. METHODS: Reviewed literature includes treatment studies of the impact of Ω3 on child mood disorders supplemented by review of meta-analyses within the adult mood disorders literature...
September 2015: Journal of Child and Adolescent Psychopharmacology
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