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supraspinatus tendinopathy

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https://www.readbyqxmd.com/read/28879051/targeting-danger-molecules-in-tendinopathy-the-hmgb1-tlr4-axis
#1
Moeed Akbar, Derek S Gilchrist, Susan M Kitson, Briana Nelis, Lindsay A N Crowe, Emma Garcia-Melchor, James H Reilly, Shauna C Kerr, George A C Murrell, Iain B McInnes, Neal L Millar
OBJECTIVES: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. METHODS: Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing 'early pathology') biopsies were collected from patients undergoing arthroscopic shoulder surgery...
2017: RMD Open
https://www.readbyqxmd.com/read/28761710/differential-expression-of-alarmins-s100a9-il-33-hmgb1-and-hif-1%C3%AE-in-supraspinatus-tendinopathy-before-and-after-treatment
#2
Michael J Mosca, Andrew J Carr, Sarah J B Snelling, Kim Wheway, Bridget Watkins, Stephanie G Dakin
BACKGROUND: Alarmins, endogenous molecules released on tissue damage have been shown to play an important role in inflammatory musculoskeletal conditions including fracture repair andrheumatoid arthritis. However, the contribution of alarmins to the pathogenesis of tendon disease is not fully understood. METHODS: We investigated expression of alarmin proteins (S100A9, high-mobility group box 1 (HMGB1) and interleukin-33 (IL-33) and hypoxia-inducible factor 1α (HIF-1α), a subunit of an oxygen sensitive transcription factor, in three cohorts of human supraspinatus tissues: healthy (n=6), painful diseased (n=13) and post-treatment pain-free tendon samples (n=5)...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28641171/electromyographic-analysis-of-rotator-cuff-muscles-in-patients-with-rotator-cuff-tendinopathy-a-systematic-review
#3
REVIEW
Fábio Carlos Lucas de Oliveira, Laurent Julien Bouyer, Amanda L Ager, Jean-Sébastien Roy
The shoulder is inherently an unstable joint which heavily relies on the neuromuscular activation of the rotator cuff (RC) complex for stability during movement. Currently, there is no consensus regarding how the activity of RC muscles is affected among individuals with a RC tendinopathy (RCTe). This study reviewed the evidence of studies comparing the electromyographic (EMG) activity of any RC muscle of shoulders with a symptomatic RCTe to asymptomatic shoulders. Eight databases were searched. Data from 343 participants (201 symptomatic and 209 asymptomatic shoulders) were analyzed from 10 out of 402 included studies...
August 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28585109/efficacy-and-tolerability-of-peritendinous-hyaluronic-acid-in-patients-with-supraspinatus-tendinopathy-a-multicenter-randomized-controlled-trial
#4
César Flores, Ramón Balius, Guillermo Álvarez, Miguel A Buil, Luisa Varela, Carlos Cano, Joaquín Casariego
BACKGROUND: Physical therapy and peritendinous hyaluronic acid (HA) injections have both shown promising results in the treatment of shoulder tendinopathies. However, the superiority of treatment combining physical therapy and HA is unclear. METHODS: Patients with ultrasound-confirmed supraspinatus tendinopathy were randomized to receive either physical therapy + subacromial HA injections or physical therapy only. Treatment efficacy was assessed using a Visual Analog Scale (VAS) for pain and an Activities of Daily Living (ADL) scale...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#5
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28197744/efficiency-of-quantitative-echogenicity-for-investigating-supraspinatus-tendinopathy-by-the-gray-level-histogram-of-two-ultrasound-devices
#6
Jiun-Cheng Hsu, Po-Han Chen, Kuo-Chin Huang, Yao-Hung Tsai, Wei-Hsiu Hsu
PURPOSE: The gray-level histogram of ultrasound is a promising tool for scanning the hypoechogenic appearance of supraspinatus tendinopathy, and the aim of this study was to test the hypothesis that the gray-level value of the supraspinatus tendon in the painful shoulder has a lower value on B-mode images even though in different ultrasound devices. METHODS: Sixty-seven patients who had unilateral shoulder pain with rotator cuff tendinopathy underwent bilateral shoulder ultrasonography, and we compared the mean gray-level values of painful shoulders and contralateral shoulders without any pain in each patient using two ultrasound devices...
February 14, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28122639/persistent-stromal-fibroblast-activation-is-present-in-chronic-tendinopathy
#7
Stephanie G Dakin, Christopher D Buckley, Mohammad Hussein Al-Mossawi, Robert Hedley, Fernando O Martinez, Kim Wheway, Bridget Watkins, Andrew J Carr
BACKGROUND: Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood. METHODS: We investigated stromal fibroblast activation signatures in tissues and cells from patients with tendinopathy. Diseased tendons were collected from well-phenotyped patient cohorts with supraspinatus tendinopathy before and after sub-acromial decompression treatment...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28002923/tendinopathic-supraspinatus-tenocytes-may-have-a-neuroendocrine-like-function-secreting-cgrp-sp-and-vegf-a-pilot-immunohistochemistry-study
#8
R Sahemey, P Malliaras, J S Lewis, G J Michael, P Shortland, D Morrissey, N Maffulli
We wanted to observe and compare the appearance of neurovascular tissue from tendon ex vivo, in patients with and without painful rotator cuff tendinopathy. Supraspinatus tendons were biopsied from 5 participants with painful tendinopathy and normal tendon from a young male. Slides were stained with haematoxylin and eosin and toluidine blue for histological assessment. Immunohistochemical markers for general nerves (protein gene-product 9.5 and synaptophysin), sensory nerves (calcitonin gene-related peptide; substance-P) and vascularisation (vascular endothelial growth factor) were used...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27914921/polydeoxyribonucleotide-injection-in-the-treatment-of-chronic-supraspinatus-tendinopathy-a-case-controlled-retrospective-comparative-study-with-6-month-follow-up
#9
COMPARATIVE STUDY
Young Chun Yoon, Doo-Hyung Lee, Michael Young Lee, Seung-Hyun Yoon
OBJECTIVE: To determine the efficacy of polydeoxyribonucleotide (PDRN) injection for rotator cuff disease (RCD). DESIGN: Case-controlled, retrospective, comparative study. SETTING: Outpatient clinic at a university-affiliated tertiary care hospital. PARTICIPANTS: Patients (N=106) with chronic nontraumatic refractory RCD who were unresponsive to at least 1 month of conservative treatment: 55 patients received PDRN injection (PDRN group) and 51 continued conservative treatment (control group)...
May 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27896393/degree-of-tendon-degeneration-and-stage-of-rotator-cuff-disease
#10
Chris Hyunchul Jo, Won Hyoung Shin, Ji Wan Park, Ji Sun Shin, Ji Eun Kim
PURPOSE: While tendon degeneration has been known to be an important cause of rotator cuff disease, few studies have objectively proven the association of tendon degeneration and rotator cuff disease. The purpose of this study was to investigate changes of tendon degeneration with respect to the stage of rotator cuff disease. METHODS: A total of 48 patients were included in the study: 12 with tendinopathy, 12 with a partial-thickness tear (pRCT), 12 with a full-thickness tear (fRCT), and 12 as the control...
November 28, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27824237/focused-extracorporeal-shock-wave-therapy-combined-with-supervised-eccentric-training-for-supraspinatus-calcific-tendinopathy
#11
Ettore Carlisi, Claudio Lisi, Anna Dall'angelo, Serena Monteleone, Vincenza Nola, Carmine Tinelli, Elena Dalla Toffola
BACKGROUND: Extracorporeal shock wave therapy is effective in reducing shoulder pain and improving function in calcific supraspinatus tendinopathy. Eccentric exercise has been introduced as an effective treatment choice for Achilles tendinopathy, but poor evidence exists about its role in the treatment of rotator cuff tendinopathy. AIM: To investigate if adding a supervised eccentric training of the shoulder abductor muscles could improve the outcome of extracorporeal shock wave therapy...
November 8, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27668218/the-use-of-adipose-derived-progenitor-cells-and-platelet-rich-plasma-combination-for-the-treatment-of-supraspinatus-tendinopathy-in-55-dogs-a-retrospective-study
#12
Sherman O Canapp, Debra A Canapp, Victor Ibrahim, Brittany Jean Carr, Catherine Cox, Jennifer G Barrett
OBJECTIVE: To report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy. METHODS: Medical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27606277/shoulder-disease-patterns-of-the-wheelchair-athletes-of-table-tennis-and-archery-a-pilot-study
#13
Byung-Chun You, Won-Jae Lee, Seung-Hwa Lee, Sol Jang, Hyun-Seok Lee
OBJECTIVE: To investigate the shoulder disease patterns for the table-tennis (TT) and archery (AR) wheelchair athletes via ultrasonographic evaluations. METHODS: A total of 35 wheelchair athletes were enrolled, made up of groups of TT (n=19) and AR (n=16) athletes. They were all paraplegic patients and were investigated for their wheelchair usage duration, careers as sports players, weekly training times, the Wheelchair User's Shoulder Pain Index (WUSPI) scores and ultrasonographic evaluation...
August 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27507844/clinical-and-ultrasonographic-evaluations-of-the-shoulders-of-elite-swimmers
#14
Scott A Rodeo, Joseph T Nguyen, John T Cavanaugh, Yashika Patel, Ronald S Adler
BACKGROUND: Shoulder pain is a common problem in competitive swimmers, but the structural alterations in elite-level competitive swimmers are not well known. HYPOTHESIS: Adaptive changes are common in the rotator cuff, bursa, labrum, and capsule in elite swimmers, and such abnormalities are related to factors concerning training and correlate with symptoms. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: The study population was the 2008 United States Olympic swimming team...
December 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27446783/influence-of-hyperlipidemia-on-the-treatment-of-supraspinatus-tendinopathy-with-or-without-tear
#15
Jae-Min Kim, Min-Wook Kim, Hyun-Jung Do
OBJECTIVE: To investigate the influence of hyperlipidemia on the treatment of supraspinatus tendinopathy, with or without tear. METHODS: We retrospectively reviewed the data of patients with shoulder pain and patients with supraspinatus tendinopathy, with or without tear, were included in the study. Exclusion criteria were prior shoulder surgery, prior steroid injection, neurological diseases that could lead to shoulder pain, and use of lipid-lowering medication...
June 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27444781/extracorporeal-shockwave-therapy-and-therapeutic-exercise-for-supraspinatus-and-biceps-tendinopathies-in-29-dogs
#16
J J Leeman, K K Shaw, M B Mison, J A Perry, A Carr, R Shultz
Supraspinatus tendinopathy (ST) and biceps tendinopathy (BT) are common causes of forelimb lameness in large-breed dogs and have historically been treated with conservative management or surgery. Extracorporeal shockwave therapy (ESWT) and therapeutic exercise (TE) are thought to be treatment options for these conditions. The objectives of this study were to report the clinical presentations of dogs treated with ESWT for shoulder tendinopathies, to determine the association between shoulder lesion severity identified on ultrasonography or MRI and outcome, and to compare the outcomes of dogs treated with ESWT with and without TE...
October 15, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27434235/dynamic-three-dimensional-shoulder-mri-during-active-motion-for-investigation-of-rotator-cuff-diseases
#17
Christine Tempelaere, Jérome Pierrart, Marie-Martine Lefèvre-Colau, Valérie Vuillemin, Charles-André Cuénod, Ulrich Hansen, Olivier Mir, Wafa Skalli, Thomas Gregory
BACKGROUND: MRI is the standard methodology in diagnosis of rotator cuff diseases. However, many patients continue to have pain despite treatment, and MRI of a static unloaded shoulder seems insufficient for best diagnosis and treatment. This study evaluated if Dynamic MRI provides novel kinematic data that can be used to improve the understanding, diagnosis and best treatment of rotator cuff diseases. METHODS: Dynamic MRI provided real-time 3D image series and was used to measure changes in the width of subacromial space, superior-inferior translation and anterior-posterior translation of the humeral head relative to the glenoid during active abduction...
2016: PloS One
https://www.readbyqxmd.com/read/27431359/ultrasonographic-measures-of-the-acromiohumeral-distance-and-supraspinatus-tendon-thickness-in-manual-wheelchair-users-with-spinal-cord-injury
#18
MULTICENTER STUDY
Amélie Fournier Belley, Dany H Gagnon, François Routhier, Jean-Sébastien Roy
OBJECTIVES: (1) To evaluate the reliability of ultrasonographic measures of the acromiohumeral distance (AHD) in shoulder positions linked to wheelchair propulsion in manual wheelchair users (MWUs) with spinal cord injury (SCI) and able-bodied individuals; (2) to compare ultrasonographic measures of AHD, supraspinatus tendon thickness, and occupation ratio between MWUs with SCI with and without shoulder pain (rotator cuff [RC] tendinopathy); and (3) to compare these ultrasonographic measures between MWUs with SCI and able-bodied individuals...
March 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27404451/intertester-reliability-of-shoulder-complaints-diagnoses-in-primary-health-care
#19
Benny Storheil, Elise Klouman, Stian Holmvik, Nina Emaus, Nils Fleten
OBJECTIVE: Shoulder complaints are frequently encountered in general practice, but precise diagnosing is challenging. This study investigated agreement of shoulder complaints diagnoses between clinicians in a primary health care setting. DESIGN: Cross-sectional study. SETTING: Four primary health care clinicians used patients' history and functional examination of the shoulder by selective tissue tension techniques (STTs), to diagnose shoulder complaints...
September 2016: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/27264348/diagnostic-value-of-angled-oblique-sagittal-images-of-the-supraspinatus-tendon-for-the-detection-of-rotator-cuff-tears-on-mr-imaging
#20
M Etancelin-Jamet, L Bouilleau, A Martin, P Bertrand
PURPOSE: The goal of this study was to evaluate the added value of sagittal T2-weighted magnetic resonance imaging (MRI) of the supraspinatus tendon by comparison with a standard MRI protocol for the evaluation of the rotator cuff. MATERIALS AND METHODS: This retrospective single center study included 100 patients referred for MRI for suspected rotator cuff injuries. Two observers compared sagittal T2-weighted fat-suppressed orthogonal images of the distal portion of the supraspinatus muscle ("cuff" protocol) to those acquired according to the standard MRI protocol, which focuses on the glenoid...
June 2, 2016: Diagnostic and Interventional Imaging
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