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https://www.readbyqxmd.com/read/29745817/impaired-mineral-quality-in-dentin-in-x-linked-hypophosphatemia
#1
Benjamin R Coyac, Guillaume Falgayrac, Guillaume Penel, Alain Schmitt, Thorsten Schinke, Agnès Linglart, Marc D McKee, Catherine Chaussain, Claire Bardet
X-linked hypophosphatemia (XLH) is a skeletal disorder arising from mutations in the PHEX gene, transmitted in most cases as an X-linked dominant trait. PHEX deficiency leads to renal phosphate wasting and hypophosphatemia, as well as impaired mineralization of bone and dentin, resulting in severe skeletal and dental complications. Dentin mineralization defects appear as characteristic, large interglobular spaces resulting from the lack of fusion of calculospherites in the circumpulpal region during the mineralization process...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29745448/early-development-of-the-human-dentition-revisited
#2
REVIEW
Maria Hovorakova, Herve Lesot, Miroslav Peterka, Renata Peterkova
In this review, classical data on the early steps in human odontogenesis are summarized and updated with specific insights into the development of the upper and lower embryonic jaws to help in understanding some oral pathologies. The initial step of human odontogenesis is classically characterized by two parallel horseshoe-shaped epithelial laminae. These originate from the oral epithelium and an ingrowth into the jaw mesenchyme: the internal dental lamina gives rise to deciduous tooth primordia, while the external vestibular lamina represents the developmental base of the oral vestibule...
May 10, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29664332/characterization-of-dental-phenotype-in-patients-with-cleidocranial-dysplasia-using-longitudinal-data
#3
Sang-Woon Ha, Yu-Jin Jung, Han-Sol Bae, Hyun-Mo Ryoo, Il-Sik Cho, Seung-Hak Baek
OBJECTIVE: To investigate the characteristics of the dental phenotype in patients with cleidocranial dysplasia (CCD) using longitudinal data. MATERIALS AND METHODS: Twelve unrelated Korean CCD patients were observed using a longitudinal series of radiographs and clinical photographs. Statistical analysis was performed on the dental phenotypic data. RESULTS: Although dysplasia of the clavicles, open fontanelle, and wormian bone were observed in all 12 patients, delayed fusion of the mandibular symphysis was found in four patients...
April 17, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29663272/fiducial-based-fusion-of-3d-dental-models-with-magnetic-resonance-imaging
#4
Amir H Abdi, Alan G Hannam, Sidney Fels
PURPOSE: Magnetic resonance imaging (MRI) is widely used in study of maxillofacial structures. While MRI is the modality of choice for soft tissues, it fails to capture hard tissues such as bone and teeth. Virtual dental models, acquired by optical 3D scanners, are becoming more accessible for dental practice and are starting to replace the conventional dental impressions. The goal of this research is to fuse the high-resolution 3D dental models with MRI to enhance the value of imaging for applications where detailed analysis of maxillofacial structures are needed such as patient examination, surgical planning, and modeling...
April 16, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29652537/subphenotyping-and-classification-of-cleft-lip-and-alveolus-in-adult-unoperated-patients-a-new-embryological-approach
#5
Christl Vermeij-Keers, Anna M Rozendaal, Antonius J M Luijsterburg, Benny S Latief, Costas Lekkas, Lea Kragt, Edwin M Ongkosuwito
OBJECTIVE: Previously, a new embryological classification was introduced subdividing oral clefts into fusion and/or differentiation defects. This subdivision was used to classify all subphenotypes of cleft lip with or without alveolus (CL±A). Subsequently, it was investigated whether further morphological grading of incomplete CLs is clinically relevant, and which alveolar part is deficient in fusion/differentiation defects. DESIGN: Observational cohort study. SETTING: Three hundred fifty adult unoperated Indonesian cleft patients presented themselves for operation...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29629440/incidental-findings-based-on-anatomical-location-and-clinical-significance-in-cbct-scans-of-dental-implant-patients
#6
Sunil Mutalik, Kandasamy Rengasamy, Aditya Tadinada
OBJECTIVE: Several incidental findings with varying degrees of clinical significance are often found on cone beam computed tomography (CBCT) scans of the maxillofacial skeleton acquired for dental procedures. The present study analyzed CBCT scans of dental implant therapy patients to identify incidental findings and assign those findings an appropriate clinical significance. METHOD AND MATERIALS: A total of 500 CBCT scans of patients were evaluated for this study...
2018: Quintessence International
https://www.readbyqxmd.com/read/29603022/cytotoxic-effects-to-mouse-and-human-gingival-fibroblasts-of-a-nanohybrid-ormocer-versus-dimethacrylate-based-composites
#7
Andrea Schubert, Christopher Ziegler, Andrea Bernhard, Ralf Bürgers, Nicolai Miosge
OBJECTIVES: Tooth-colored composites have emerged as a standard restorative material in caries therapy and have largely replaced materials such as silver amalgam or glass ionomer cements. In addition to their superior esthetics and desirable mechanical properties, composites also comprise negative characteristics, such as wear, shrinkage, and an adverse biocompatibility. Modifications of classic resin-based dental composites have been developed to overcome these shortcomings. For example, ormocers are innovative inorganic-organic hybrid polymers that form a siloxane network modified by the incorporation of organic groups...
March 30, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29535920/metal-artifact-suppression-in-dental-cone-beam-computed-tomography-images-using-image-processing-techniques
#8
Masoumeh Johari, Milad Abdollahzadeh, Farzad Esmaeili, Vahideh Sakhamanesh
Background: Dental cone beam computed tomography (CBCT) images suffer from severe metal artifacts. These artifacts degrade the quality of acquired image and in some cases make it unsuitable to use. Streaking artifacts and cavities around teeth are the main reason of degradation. Methods: In this article, we have proposed a new artifact reduction algorithm which has three parallel components. The first component extracts teeth based on the modeling of image histogram with a Gaussian mixture model...
January 2018: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29491623/fusion-of-maxillary-central-incisors-with-mesiodens
#9
Madhuram Krishnamurthy, V Naveen Kumar, Ashok Leburu, Nadeem Jeddy
Fusion and gemination are developmental anomalies which are quite similar to each other but can be distinguished from each other if properly assessed. Fusion and gemination have been described as a result of developmental anomalies of dental tissues. The exact etiology is still unknown, but a genetic predisposition is suggested. This article highlights the importance of clinical and radiographic correlation in arriving at a definitive diagnosis.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29405385/specificity-protein-7-is-required-for-proliferation-and-differentiation-of-ameloblasts-and-odontoblasts
#10
Ji-Myung Bae, John C Clarke, Harunur Rashid, Mitra D Adhami, Kayla McCullough, Jordan S Scott, Haiyan Chen, Krishna M Sinha, Benoit de Crombrugghe, Amjad Javed
The Sp7/Osterix transcription factor is essential for bone development. Mutations of the Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta. However, the role of Sp7 in embryonic tooth development remains unknown. Here we identified the functional requirement of Sp7 for dentin synthesis and tooth development. Sp7-null mice exhibit craniofacial dysmorphogenesis and are completely void of alveolar bone. Surprisingly, initial tooth morphogenesis progressed normally in Sp7-null mice...
February 5, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29402820/primary-fused-teeth-and-findings-in-permanent-dentition
#11
Hatice Açıkel, Sevgin İbiş, Emine Şen Tunç
OBJECTIVE: The aim of this study was to investigate the characteristics of primary fused teeth (PFT) and its effects on permanent dentition in a group of Turkish children. SUBJECTS AND METHODS: Dental records of 13,450 paediatric patients who attended the Paediatric Dental Clinic in Northern Turkey between 2015 and 2017 were reviewed. Forty patients had been diagnosed with PFT and were included in this study. Clinical and radiographic examinations were conducted, and the distribution of PFT was calculated by type, sex, affected jaw, associated dental anomalies and clinical complications...
February 1, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29234185/ellis-van-creveld-with-an-unusual-dental-anomaly-a-case-report
#12
Suzanne Tanya Nethan, Shruti Sinha, Sunira Chandra
The Ellis-van Creveld (EVC) syndrome is a chondroectodermal dysplasia and is characterized by the cardinal features of disproportionate short stature, polydactyly, hidrotic ectodermal dysplasia, and congenital heart malformations, along with other skeletal and dental abnormalities. It is a rare condition, with very few cases reported in the medical literature. It is inherited as an autosomal recessive disorder with variable expressions, due to the mutation of the EVC syndrome 1 and 2 genes, which are located on chromosome 4p16...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29223396/accelerated-dentinogenesis-by-inhibiting-the-mitochondrial-fission-factor-dynamin-related-protein-1
#13
Yumiko I Matsuishi, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Hiroko Wada, Tamotsu Kiyoshima, Kazuaki Nonaka
Undifferentiated odontogenic epithelium and dental papilla cells differentiate into ameloblasts and odontoblasts, respectively, both of which are essential for tooth development. These differentiation processes involve dramatic functional and morphological changes of the cells. For these changes to occur, activation of mitochondrial functions, including ATP production, is extremely important. In addition, these changes are closely related to mitochondrial fission and fusion, known as mitochondrial dynamics...
January 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29220087/dual-energy-based-metal-segmentation-for-metal-artifact-reduction-in-dental-computed-tomography
#14
Mohamed A A Hegazy, Mohamed Elsayed Eldib, Daniel Hernandez, Myung Hye Cho, Min Hyoung Cho, Soo Yeol Lee
PURPOSE: In a dental CT scan, the presence of dental fillings or dental implants generates severe metal artifacts that often compromise readability of the CT images. Many metal artifact reduction (MAR) techniques have been introduced, but dental CT scans still suffer from severe metal artifacts particularly when multiple dental fillings or implants exist around the region of interest. The high attenuation coefficient of teeth often causes erroneous metal segmentation, compromising the MAR performance...
February 2018: Medical Physics
https://www.readbyqxmd.com/read/29090126/multidisciplinary-management-of-a-fused-maxillary-central-incisor-moved-through-the-midpalatal-suture-a-case-report
#15
Hakan Bulut, Aylin Pasaoglu
Fusion of teeth is a developmental anomaly. It occurs at the stage of tooth formation, which determines the shape and size of the tooth crown, when one or more teeth fuse at the dentin level during the morphodifferentiation of the dental germs. Such teeth show macrodontia and may cause crowding, as well as esthetic and endodontic problems. In this article, we report a rare case of a maxillary central incisor fused to a supernumerary tooth showing labial and palatal talon cusps, which was orthodontically moved across the midpalatal suture...
November 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29042739/robinow-syndrome-and-fusion-of-primary-teeth
#16
Priti Sushil Jain, Tejashri Shreyas Gupte, Abdulkadeer M Jetpurwala, Shely Pratik Dedhia
Managing patients with rare genetic disorders is a challenge that dentists face often. Robinow syndrome (RS) is one such rare genetic disorder with <200 cases reported worldwide. RS demonstrates multiple craniofacial abnormalities and orodental disorders, which need to be taken into consideration by a dental practitioner while rendering dental care.
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042079/cytotoxicity-and-dna-double-strand-breaks-in-human-gingival-fibroblasts-exposed-to-eluates-of-dental-composites
#17
Yang Yang, Franz-Xaver Reichl, Jianwei Shi, Xiuli He, Reinhard Hickel, Christof Högg
OBJECTIVE: Previously, single composite components were used to study cytotoxicity and induction of DNA double-strand breaks (DNA-DSBs) of dental composite resins. In the present study, cytotoxicity and induction of DNA-DSBs in human gingival fibroblasts (HGFs) were investigated with dental composite eluates consisting of multiple components. The eluates were qualified and quantified. METHODS: The composites Esthet.X® HD, Venus® , X-tra fil® , CLEARFIL™ AP-X, Admira® Fusion and QuiXfil® were polymerized and immersed into Dulbecco's modified Eagle's medium (DMEM) for 72h...
February 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29029849/impact-of-the-heating-quenching-process-on-the-mechanical-optical-and-thermodynamic-properties-of-polyetheretherketone-peek-films
#18
Lisa Bodden, Nina Lümkemann, Valerie Köhler, Marlis Eichberger, Bogna Stawarczyk
OBJECTIVE: The aim of this study was to investigate the impact of a heating/quenching process on the optical, mechanical and thermodynamic properties of filled (20%_4000) and unfilled PEEK films (0%_2000 and 0%_4000). Heating/quenching was performed to simulate thermoforming as possible method to process thermoplastic polymers for dental application. METHODS: For the investigation, films of different PEEK qualities (0%_2000, 0%_4000, 20%_4000) were produced using isostatic pressing (n=10/quality)...
December 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28933802/invesigation-of-prevalence-of-dental-anomalies-by-using-digital-panoramic-radiographs
#19
Nebiha Hilal Bilge, Selin Yeşiltepe, Kübra Törenek Ağırman, Fatma Çağlayan, Osman Murat Bilge
BACKGROUND: This study was performed to evaluate the prevalence of all types and subtypes of dental anomalies among 6 to 40 year-old patients by using panoramic radiographs. MATERIALS AND METHODS: This cross-sectional study was conducted by analyzing digital panoramic radiographs of 1200 patients admitted to our clinic in 2014. Dental anomalies were examined under 5 types and 16 subtypes. Dental anomalies were divided into five types: (a) number (including hypodontia, oligodontia and hyperdontia); (b) size (including microdontia and macrodontia); (c) structure (including amelogenesis imperfecta, dentinogenesis imperfecta and dentin dysplasia); (d) position (including transposition, ectopia, displacement, impaction and inversion); (e) shape (including fusion-gemination, dilaceration and taurodontism); RESULTS: The prevalence of dental anomalies diagnosed by panoramic radiographs was 39...
September 21, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28929117/histological-evidence-of-the-osseointegration-of-fractured-direct-metal-laser-sintering-implants-retrieved-after-5-years-of-function
#20
Francesco Mangano, Carlo Mangano, Adriano Piattelli, Giovanna Iezzi
BACKGROUND: Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential to enhance and accelerate bone healing. To date, however, there are no histologic/histomorphometric studies in the literature evaluating the interface between bone and DMLS implants in the long-term...
2017: BioMed Research International
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