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Vascular parkinsonism

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https://www.readbyqxmd.com/read/27900498/central-hemodynamics-and-arterial-stiffness-in-idiopathic-and-multiple-system-atrophy
#1
Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A Schneider
Blood pressure is commonly abnormal in parkinsonian disorders, but central hemodynamics and arterial stiffness, well-established predictors of total cardiovascular risk, have rarely been studied in these disorders. 32 patients [27 with idiopathic Parkinson's disease (iPD); 5 with multiple system atrophy (MSA)] and 15 controls matched for cardiac risk factors underwent 24 h-ambulatory blood pressure recordings using an I.E.M. device (Mobil-O-Graph™), measuring peripheral pressure and calculating central pressures and arterial stiffness...
November 29, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27872856/altered-expression-of-epo-might-underlie-hepatic-hemangiomas-in-lrrk2-knockout-mice
#2
Ben Wu, Kaifu Xiao, Zhuohua Zhang, Long Ma
Parkinson's disease (PD) is a severe neurodegenerative disorder caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. The molecular mechanism of PD pathogenesis is unclear. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common genetic cause of familial and sporadic PD. However, studies on LRRK2 mutant mice revealed no visible dopaminergic neuronal loss in the midbrain. While surveying a LRRK2 knockout mouse strain, we found that old animals developed age-dependent hepatic vascular growths similar to cavernous hemangiomas...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27848965/sulfheme-formation-during-homocysteine-s-oxygenation-by-catalase-in-cancers-and-neurodegenerative-diseases
#3
Dominique Padovani, Assia Hessani, Francine T Castillo, Géraldine Liot, Mireille Andriamihaja, Annaïg Lan, Camilla Pilati, François Blachier, Suvajit Sen, Erwan Galardon, Isabelle Artaud
Accumulating evidence suggests that abnormal levels of homocysteine are associated with vascular dysfunctions, cancer cell proliferation and various neurodegenerative diseases. With respect to the latter, a perturbation of transition metal homeostasis and an inhibition of catalase bioactivity have been reported. Herein, we report on some of the molecular bases for the cellular toxicity of homocysteine and demonstrate that it induces the formation of sulfcatalase, an irreversible inactive state of the enzyme, without the intervention of hydrogen sulfide...
November 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27844282/morphological-changes-in-a-severe-model-of-parkinson-s-disease-and-its-suitability-to-test-the-therapeutic-effects-of-microencapsulated-neurotrophic-factors
#4
C Requejo, J A Ruiz-Ortega, H Bengoetxea, A García-Blanco, E Herrán, A Aristieta, M Igartua, J L Pedraz, L Ugedo, R M Hernández, J V Lafuente
The unilateral 6-hydroxydopamine (6-OHDA) lesion of medial forebrain bundle (MFB) in rats affords us to study the advanced stages of Parkinson's disease (PD). Numerous evidences suggest synergic effects when various neurotrophic factors are administered in experimental models of PD. The aim of the present work was to assess the morphological changes along the rostro-caudal axis of caudo-putamen complex and substantia nigra (SN) in the referred model in order to test the suitability of a severe model to evaluate new neurorestorative therapies...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27830890/adrenal-medulla-of-as-agu-rats-a-histological-and-immunohistochemical-study
#5
Musaad A Al-Fayez, Muhammad Atteya, Raeesa A Mohamed, Aly M Ahmed, Ali Hussein Alroalle, Mahmoud Salah Khalil, Mohammed Al-Ahmed, Anthony Payne
BACKGROUND: The outcome of the autogrfat therapy for Parkinson's disease including autologous cells from adrenal medulla was disappointing. This could be attributed to the pathological process in Parkinson's disease affecting cells of the adrenal medulla. This study was performed to investigate the histopathological changes in the adrenal medulla of AS/AGU rat, a model of Parkinson's disease, in comparison with Albino Swiss (AS) rats. MATERIALS AND METHODS: A total of 24 male AS rats were divided into four groups, each of 6 animals: AS W1, AS rats aged one week; AS adult, AS adult rats; AS/AGU W1, AS/AGU rats aged one week; and AS/AGU adult, AS/AGU adult rats...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27801938/causes-of-death-according-to-death-certificates-in-individuals-with-dementia-a-cohort-from-the-swedish-dementia-registry
#6
Sara Garcia-Ptacek, Ingemar Kåreholt, Pavla Cermakova, Debora Rizzuto, Dorota Religa, Maria Eriksdotter
OBJECTIVES: The causes of death in dementia are not established, particularly in rarer dementias. The aim of this study is to calculate risk of death from specific causes for a broader spectrum of dementia diagnoses. DESIGN: Cohort study. SETTING: Swedish Dementia Registry (SveDem), 2007-2012. PARTICIPANTS: Individuals with incident dementia registered in SveDem (N = 28,609); median follow-up 741 days. Observed deaths were 5,368 (19%)...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27784025/arterial-stiffness-and-cardiovascular-autonomic-dysfunction-in-patients-with-parkinson-s-disease
#7
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
BACKGROUND: Pulse wave velocity is a marker of arterial stiffness and a surrogate marker of vascular damage. Autonomic abnormalities associated with blood pressure are relatively commonly observed in patients with Parkinson's disease (PD). OBJECTIVE: The purpose of this study was to compare arterial stiffness between patients with PD and controls and investigate the associations between cardiovascular autonomic dysfunction and pulse wave velocity in PD. METHODS: One hundred twenty-five PD patients without diabetes mellitus were enrolled into this study, along with 22 age-matched controls...
October 27, 2016: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27770207/gait-disorders-in-adults-and-the-elderly-a%C3%A2-clinical-guide
#8
Walter Pirker, Regina Katzenschlager
Human gait depends on a complex interplay of major parts of the nervous, musculoskeletal and cardiorespiratory systems. The individual gait pattern is influenced by age, personality, mood and sociocultural factors. The preferred walking speed in older adults is a sensitive marker of general health and survival. Safe walking requires intact cognition and executive control. Gait disorders lead to a loss of personal freedom, falls and injuries and result in a marked reduction in the quality of life. Acute onset of a gait disorder may indicate a cerebrovascular or other acute lesion in the nervous system but also systemic diseases or adverse effects of medication, in particular polypharmacy including sedatives...
October 21, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27687251/fully-automated-structural-mri-of-the-brain-in-clinical-dementia-workup
#9
Karin Persson, Geir Selbæk, Anne Brækhus, Mona Beyer, Maria Barca, Knut Engedal
BACKGROUND: The dementia syndrome has been regarded a clinical diagnosis but the focus on supplemental biomarkers is increasing. An automatic magnetic resonance imaging (MRI) volumetry method, NeuroQuant® (NQ), has been developed for use in clinical settings. PURPOSE: To evaluate the clinical usefulness of NQ in distinguishing Alzheimer's disease dementia (AD) from non-dementia and non-AD dementia. MATERIAL AND METHODS: NQ was performed in 275 patients diagnosed according to the criteria of ICD-10 for AD, vascular dementia and Parkinson's disease dementia (PDD); the Winblad criteria for mild cognitive impairment; the Lund-Manchester criteria for frontotemporal dementia; and the revised consensus criteria for Lewy body dementia (LBD)...
September 28, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27671901/statins-are-underused-in-recent-onset-parkinson-s-disease-with-increased-vascular-risk-findings-from-the-uk-tracking-parkinson-s-and-oxford-parkinson-s-disease-centre-opdc-discovery-cohorts
#10
Diane M A Swallow, Michael A Lawton, Katherine A Grosset, Naveed Malek, Johannes Klein, Fahd Baig, Claudio Ruffmann, Nin P Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Thomas Foltynie, Huw R Morris, Nigel Williams, Nicholas W Wood, Michele T M Hu, Donald G Grosset
BACKGROUND: Cardiovascular disease (CVD) influences phenotypic variation in Parkinson's disease (PD), and is usually an indication for statin therapy. It is less clear whether cardiovascular risk factors influence PD phenotype, and if statins are prescribed appropriately. OBJECTIVES: To quantify vascular risk and statin use in recent-onset PD, and examine the relationship between vascular risk, PD severity and phenotype. METHODS: Cardiovascular risk was quantified using the QRISK2 calculator (high ≥20%, medium ≥10 and <20%, low risk <10%)...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27668644/the-renin-angiotensin-aldosterone-system-raas-physiology-and-molecular-mechanisms-of-functioning
#11
Monika Chaszczewska-Markowska, Maria Sagan, Katarzyna Bogunia-Kubik
Secretion of renin juxtaglomerular cells into bloodstream initiates activation of an enzymatic-hormonal cascade known as the RAAS (renin - angiotensin - aldosterone system). As a result, blood pressure is increased by the means several interrelated mechanisms. Mechanism of Zjednoczoaction of this system has been known for decades, but a few previously unknown components were recently added, such as ACE-2 and Ang(1-7), and their role often seems to be opposite to that of the conventional components. Local tissue systems also have important biological functions...
September 13, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27659216/impact-of-the-secretome-of-human-mesenchymal-stem-cells-on-brain-structure-and-animal-behavior-in-a-rat-model-of-parkinson-s-disease
#12
Fábio G Teixeira, Miguel M Carvalho, Krishna M Panchalingam, Ana J Rodrigues, Bárbara Mendes-Pinheiro, Sandra Anjo, Bruno Manadas, Leo A Behie, Nuno Sousa, António J Salgado
: : Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated therapeutic benefits are mainly due to their secretome, which has been proposed as a possible therapeutic tool for the treatment of Parkinson's disease (PD). Indeed, it has been shown that the MSC secretome increases neurogenesis and cell survival, and has numerous neuroprotective actions under different conditions. Additionally, using dynamic culturing conditions (through computer-controlled bioreactors) can further modulate the MSC secretome, thereby generating a more potent neurotrophic factor cocktail (i...
September 22, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27642535/the-effect-of-hyperhomocysteinemia-on-motor-symptoms-cognitive-status-and-vascular-risk-in-patients-with-parkinson-s-disease
#13
Bilge Kocer, Hayat Guven, Isik Conkbayir, Selim Selcuk Comoglu, Sennur Delibas
Factors related with hyperhomocysteinemia (HHcy) and the impact of HHcy in Parkinson's disease (PD) are not well understood. We investigated the factors associated with increased levels of homocysteine (Hcy) and the relationship between HHcy and motor symptoms, cognitive status, and vascular risk in patients with Parkinson's disease. Among 60 patients (29 males, 48.3%) with PD, the stage of the disease, the severity of clinical symptoms, and the patients' cognitive status were measured using a modified Hoehn and Yahr Staging Scale (mHY), Unified Parkinson's Disease Rating Scale (UPDRS) II and III, and Mini-Mental State Examination (MMSE), respectively...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27635607/-possibilities-of-non-drug-treatment-for-parkinson-s-disease
#14
D V Pokhabov, V G Abramov, D D Pokhabov
In this article, non-drug methods of treatment of Parkinson's disease are reviewed. Particular attention is given to the motor symptoms of disease, specifically to gait disorders. Information about objective methods of gait impairment is presented. Own results that confirm the effect of a method of tempo-rhythmical correction of walk in patients with Parkinson's disease (PD) and vascular parkinsonism as well as a device for assessment of gait parameters developed by the authors are analyzed. The efficacy of other methods of gait correction using external cues, study design and level of evidence are analyzed as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27631214/circulating-biomarkers-in-acute-myofascial-pain-a-case-control-study
#15
Liza Grosman-Rimon, William Parkinson, Suneel Upadhye, Hance Clarke, Joel Katz, John Flannery, Philip Peng, Dinesh Kumbhare
The aims of the present study were to compare levels of circulating inflammatory biomarkers and growth factors between patients with myofascial pain syndrome (MPS) and healthy control participants, and to assess the relationship among inflammatory markers and growth factors in the two groups.Biomarkers levels were assessed in patients (n = 37) with myofascial pain complaints recruited from the hospital emergency department and non-MPS controls (n = 21), recruited via advertisements in the hospital and community...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27553511/medium-term-prognosis-of-an-incident-cohort-of-parkinsonian-patients-compared-to-controls
#16
S Fielding, A D Macleod, C E Counsell
BACKGROUND: The best data on prognosis comes from population-based incident cohorts but few such cohorts exist for Parkinson's disease and atypical parkinsonism. METHODS: The PINE study is a prospective follow-up study of an incident cohort of people with degenerative or vascular parkinsonism and age-sex matched controls. Participants have annual follow-up from diagnosis until death with review of primary/secondary care records and linkage to the UK death register...
November 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27542570/cysteinyl-leukotrienes-and-their-receptors-emerging-therapeutic-targets-in-central-nervous-system-disorders
#17
REVIEW
Arijit Ghosh, Fang Chen, Abhimanyu Thakur, Hao Hong
Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the role of these inflammatory mediators in a broader range of diseases such as in the inflammation associated with the central nervous system (CNS) disorders, vascular inflammation (atherosclerotic), and in cancer...
December 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27541930/modulation-of-dopaminergic-pathways-to-treat-erectile-dysfunction
#18
Ulf Simonsen, Simon Comerma-Steffensen, Karl-Erik Andersson
The currently recommended first-line treatments of erectile dysfunction, phosphodiesterase type 5 inhibitors (PDE5i), e.g. sildenafil, are efficacious in many patients with erectile dysfunction of vascular origin, but this therapy is insufficient in approximately 30-40% of men with erectile dysfunction where there is also a neuronal affection. There is a demand of novel approaches to treat the condition. We review the possibility of modulating the dopaminergic pathways to improve erectile function. Dopamine D1 (D1 , D5 )-and D2 (D2 -D4 )-like receptors in the paraventricular area, the medial preoptic area, the spinal cord, and in the erectile tissue are involved in erection, and several agonists developed for treatment of Parkinson's disease are associated with increased libido...
August 19, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27525728/evaluation-of-retinal-vessel-morphology-in-patients-with-parkinson-s-disease-using-optical-coherence-tomography
#19
Robert Kromer, Carsten Buhmann, Ute Hidding, Matthias Keserü, Diana Keserü, Andrea Hassenstein, Birthe Stemplewitz
PURPOSE: The retina has been found affected in Parkinson's disease (PD). It is unclear if this is due to neurodegeneration of local dopamine-dependent retinal cells, a result of central nervous degeneration including the optic nerve or retinal small vessel disease. This study aimed to detect changes of the retinal vasculature in PD patients compared to controls. METHODS: We examined 49 PD patients and 49 age- and sex-matched healthy controls by spectral domain optical coherence tomography (SD-OCT) with a circular scan centred at the optic disc...
2016: PloS One
https://www.readbyqxmd.com/read/27486046/inflammasomes-link-vascular-disease-with-neuroinflammation-and-brain-disorders
#20
REVIEW
Nikolett Lénárt, David Brough, Ádám Dénes
The role of inflammation in neurological disorders is increasingly recognised. Inflammatory processes are associated with the aetiology and clinical progression of migraine, psychiatric conditions, epilepsy, cerebrovascular diseases, dementia and neurodegeneration, such as seen in Alzheimer's or Parkinson's disease. Both central and systemic inflammatory actions have been linked with the development of brain diseases, suggesting that complex neuro-immune interactions could contribute to pathological changes in the brain across multiple temporal and spatial scales...
October 2016: Journal of Cerebral Blood Flow and Metabolism
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