keyword
https://read.qxmd.com/read/38365438/the-association-between-work-interval-regularity-and-sleep-regularity-a-two-week-observational-study-in-daytime-employees
#21
JOURNAL ARTICLE
Hiroki Ikeda, Tomohide Kubo
OBJECTIVES: Several health issues are associated with irregular sleep patterns. However, it is unclear what causes workers to sleep irregularly. The work interval (WI) between the end of one day's working hours and the start of the next day's working hours contains sleep opportunities, and an irregular WI may result in irregular sleep. This study investigated this association among Japanese daytime workers. METHODS: This study recruited 141 daytime workers without shiftwork for a 14-day observational study...
February 14, 2024: Journal of Occupational Health
https://read.qxmd.com/read/38357726/development-of-optic-disc-edema-during-30-days-of-hypercapnic-head-down-tilt-bed-rest-is-associated-with-short-sleep-duration-and-blunted-temperature-amplitude
#22
JOURNAL ARTICLE
Kate H Christian, Carla Petitti, Kyra Ortega-Schwartz, Edwin Mulder, Alexandra Noppe, Melanie von der Wiesche, Claudia Stern, Millennia Young, Brandon R Macias, Steven S Laurie, Andrew T Lovering
Sleep and circadian temperature disturbances occur with spaceflight and may, in part, result from the chronically elevated carbon dioxide (CO2 ) levels on the International Space Station. Impaired sleep may contribute to decreased glymphatic clearance and, when combined with the chronic headward fluid shift during actual spaceflight or the spaceflight analogue head-down tilt bed rest (HDTBR), may contribute to the development of optic disc edema. We determined if strict HDTBR combined with mildly elevated CO2 levels influenced sleep and core temperature and was associated with the development of optic disc edema...
February 15, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38357145/preoperative-bowel-preparation-promotes-intestinal-functional-recovery-after-esophagectomy
#23
JOURNAL ARTICLE
Junliang Ma, Shaolin Chen, Xiaoying Ren, Hao Han, Ming Gong, Yongxiang Song, Lijuan Liu
BACKGROUND: Patients are prone to intestinal dysfunction after esophagectomy. The value of preoperative bowel preparation before esophagectomy is controversial. There is a lack of evidence as to whether preoperative bowel preparation can help patients improve bowel function and shorten the recovery time of bowel function. OBJECTIVES: The objectives of this study were to explore whether preoperative bowel preparation can promote the recovery of intestinal function after esophagectomy...
September 2023: African Health Sciences
https://read.qxmd.com/read/38346506/cosmic-chronometers-is-spaceflight-a-catalyst-for-biological-ageing
#24
REVIEW
Manuela Campisi, Luana Cannella, Sofia Pavanello
Astronauts returning from space missions often exhibit health issues mirroring age-related conditions, suggesting spaceflight as a potential driver of biological ageing and age-related diseases. To unravel the underlying mechanisms of these conditions, this comprehensive review explores the impact of the space "exposome" on the twelve hallmarks of ageing. Through a meticulous analysis encompassing both space environments and terrestrial analogs, we aim to decipher how different conditions influence ageing hallmarks...
February 10, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38343303/bed-rest-and-exercise-remobilization-concurrent-adaptations-in-muscle-glucose-and-protein-metabolism
#25
JOURNAL ARTICLE
Natalie F Shur, Elizabeth J Simpson, Hannah Crossland, Despina Constantin, Sally M Cordon, Dumitru Constantin-Teodosiu, Francis B Stephens, Matthew S Brook, Philip J Atherton, Kenneth Smith, Daniel J Wilkinson, Olivier E Mougin, Christopher Bradley, Ian A Macdonald, Paul L Greenhaff
BACKGROUND: Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same individuals. Moreover, the impact of short-term exercise-supplemented remobilization (ESR) on muscle volume, protein turnover and leg glucose uptake (LGU) in humans is unknown. METHODS: Ten healthy males (24 ± 1 years, body mass index 22...
February 12, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38342807/influence-of-a-passive-tilt-test-on-the-proteomic-composition-of-the-blood-of-healthy-humans
#26
JOURNAL ARTICLE
D N Kashirina, L Kh Pastushkova, A S Kononikhin, A G Brzhozovskiy, I M Larina
In order to identify changes in the blood proteome of healthy volunteers after passive tilt test carried out on day 19 of head-down bed rest, a chromato-mass-spectrometric analysis of samples of dried blood spots was carried out. It was revealed that the body's response to the tilt test was characterized by a decrease in the level of HDL and kininogen-1. After the tilt test, we observed an increase in the level of vimentin, vitamin K-dependent protein C, Wnt signaling pathway proteins, proteins involved in autophagy and adaptive immune response, focal adhesion proteins, vascular damage marker S100A8, PEDF regulator, and some proteins of the heart: cardiac actin ACTC1 and transcription factor GATA4...
February 12, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38338156/evaluation-of-claw-lesions-in-beef-cattle-slaughtered-in-northern-portugal-a-preliminary-study
#27
JOURNAL ARTICLE
Mafalda Seixas, Dina Moura, Luca Grispoldi, Beniamino Cenci-Goga, Sónia Saraiva, Filipe Silva, Isabel Pires, Cristina Saraiva, Juan García-Díez
Claw diseases have a profound impact on cattle welfare, affecting behaviors such as grazing, rumination, rest, decubitus, and water consumption. This study aimed to assess the prevalence of claw lesions and classify them according to the ICAR Claw Health Atlas (International Committee of Animal Recording) in two slaughterhouses. The influence of claw lesions on carcass weight, classification, and fat deposition was also examined. Involving 343 crossbreed cattle from 103 different extensive or semi-intensive farms, this study found an animal prevalence of claw disorders at 65...
February 4, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38336613/combined-rectus-sheath-block-with-transverse-abdominis-plane-block-by-one-puncture-for-analgesia-after-laparoscopic-upper-abdominal-surgery-a-randomized-controlled-prospective-study
#28
JOURNAL ARTICLE
Shan Yu, Yaling Wen, Jing Lin, Jinghao Yang, Yihang He, Youbo Zuo
BACKGROUND: Rectus sheath block (RSB) and transversus abdominis plane block (TAPB) have been shown to reduce opioid consumption and decrease postoperative pain scores in abdominal surgeries. However, there are no reports about the one-puncture technique of RSB combined with TAPB for perioperative pain management during laparoscopic upper abdominal surgery. METHODS: A total of 58 patients were randomly assigned to the control group (C), the TAP group (T), and the one-puncture technique of RSB combined with TAPB group (RT)...
February 9, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38329184/an-investigation-of-cerebral-vascular-functional-properties-in-middle-to-old-age-community-people-with-high-vascular-risk-profiles
#29
JOURNAL ARTICLE
Yao Zhang, Ruiting Zhang, Hui Hong, Shuyue Wang, Linyun Xie, Lei Cui, Jixuan Li, Luwei Hong, Kaicheng Li, Qingze Zeng, Ying Zhou, Minming Zhang, Jianzhong Sun, Peiyu Huang
BACKGROUND: Vascular degeneration is an important cause of brain damage in aging. Assessing the functional properties of the cerebral vascular system may aid early diagnosis and prevention. PURPOSE: To investigate the relationships between potential vascular functional markers and vascular risks, brain parenchymal damage, and cognition. STUDY TYPE: Retrospective. SUBJECTS: Two hundred two general community subjects (42-80 years, males/females: 127/75)...
February 8, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38328428/effect-of-15%C3%A2-days-6%C3%A2-head-down-bed-rest-on-microbial-communities-of-supragingival-plaque-in-young-men
#30
JOURNAL ARTICLE
Di Zhu, Pengyan Qiao, Qian Zhou, Hui Sun, Bingmu Xin, Bin Wu, Chuhua Tang
INTRODUCTION: The microgravity environment astronauts experience during spaceflight can lead to an increased risk of oral diseases and possible changes in oral microecology. In this study, we aimed to assess changes in the microbial community of supragingival plaques to explore the effects of spaceflight microgravity environment on oral microecology. METHODS: Sixteen healthy male volunteers were recruited, and supragingival plaque samples were collected under -6° head-down bed rest (HDBR) at five-time points: day 1 before HDBR; days 5, 10, and 15 of HDBR; and day 6 of recovery...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38326800/nurses-perceptions-of-the-transition-to-100-single-occupancy-patient-rooms-in-a-university-hospital-in-the-netherlands-an-uncontrolled-before-and-after-study
#31
JOURNAL ARTICLE
Ralph Pruijsten, Erwin Ista, Jill Maben, Liesbeth van Heel, Monique van Dijk
BACKGROUND: To improve patients' privacy, comfort and infection control, newly built hospitals increasingly offer 100% single-occupancy patient rooms. Our study examines how nurses perceived the transition from a hospital with multi-bedded patient rooms to one with solely single-occupancy patient rooms designed according to principles of a healing environment. METHODS: In a single-centre, before-after survey study, nurses completed a questionnaire of 21 items in three domains: perceived patient safety and monitoring, nurses' working conditions and patient environment...
February 8, 2024: BMC Nursing
https://read.qxmd.com/read/38324171/patient-use-patterns-of-portable-oxygen-concentrators
#32
JOURNAL ARTICLE
Stanislav Glezer, Michael W Hess, Alan K Kamada
INTRODUCTION: Portable oxygen concentrators (POCs) are medical devices that provide supplemental oxygen to patients requiring long-term oxygen therapy. However, little information is available on day-to-day patterns of how or even whether patients actively switch between their POC mobility features and flow setting options. METHODS: A retrospective analysis was conducted to assess POC usage among patients who used an Inogen One G5 POC in the USA. This study aimed (1) to describe the patterns of use of POCs, (2) to analyze their compatibility with the prescribed oxygen therapy settings, and (3) to demonstrate the contribution of POC usage to get a standardized long-term oxygen therapy (LTOT)...
February 7, 2024: Pulmonary Therapy
https://read.qxmd.com/read/38323829/safety-and-effectiveness-of-an-enhanced-recovery-protocol-in-patients-undergoing-burr-hole-evacuation-for-chronic-subdural-hematoma
#33
JOURNAL ARTICLE
Victor E Staartjes, Antonio Spinello, Nina Schwendinger, Menno R Germans, Carlo Serra, Luca Regli
BACKGROUND AND OBJECTIVES: Enhanced recovery programs may be especially useful in patients with chronic subdural hematoma or hygroma (cSDH), who frequently exhibit frailty and multimorbidity. We aim to evaluate the real-world safety and effectiveness of an enhanced recovery protocol in this population. METHODS: From a prospective registry, burr hole evacuations for cSDH carried out under the protocol (including early thromboprophylaxis, no flat bed rest, early mobilization without drain clamping, and early resumption of antithrombotic medication) were extracted, along with those procedures carried out within the past year before protocol change...
February 7, 2024: Neurosurgery
https://read.qxmd.com/read/38313716/intracranial-hypotension-with-subdural-hematoma-after-spinal-anesthesia-in-obstetric-patient-a-rare-but-fatal-complication
#34
Sujit J Kshirsagar, Anandkumar H Pande, Sanyogita V Naik, Neha M Kamble
Intracranial bleed in the form of subdural hematoma (SDH) with intracranial hypotension after spinal anesthesia for cesarean section is a rare condition with an incidence of around 1 in 5,00,000 obstetric populations. As its presentation is similar to post-dural puncture headache (PDPH), it can be misdiagnosed sometimes. Persistent headache for more than 5 days, vomiting, blurring of vision, and convulsion can guide the diagnosis of intracranial bleed. Magnetic resonance imaging (MRI) helps to diagnose the location, size, and other abnormalities of bleed in such patients...
2024: Saudi Journal of Anaesthesia
https://read.qxmd.com/read/38311665/cancer-associated-thrombosis-and-bleeding
#35
REVIEW
Takayuki Ikezoe
Development of thrombosis is closely associated with poor prognosis in cancer patients. Cancer patients often fulfill Virchow's triad of hyper-coagulable state, vascular endothelial injury, and venous stasis. Cancer cells aberrantly express a variety of procoagulant factors, including tissue factor and podoplanin. Chemotherapeutic agents and radiation cause vascular endothelial injury, and reduced daily activity and bed rest for chemotherapy lead to venous stasis. Due to these factors, cancer patients are at high risk of developing thrombosis...
February 4, 2024: International Journal of Hematology
https://read.qxmd.com/read/38301938/reproducibility-of-laser-doppler-flowmetry-in-gingival-microcirculation-a-study-on-six-different-protocols
#36
JOURNAL ARTICLE
Aida Ajan, Karin Roberg, Ingemar Fredriksson, Jahan Abtahi
OBJECTIVES: Laser Doppler Flowmetry (LDF) is a non-invasive technique for the assessment of tissue blood flow, but increased reproducibility would facilitate longitudinal studies. The aim of the study was to assess the interday reproducibility of Laser Doppler Flowmetry (LDF) at rest, at elevated local temperatures, and with the use of the vasodilator Methyl Nicotinate (MN) in six interconnected protocols for the measurement of the blood supply to the microvascular bed of the gingiva...
January 30, 2024: Microvascular Research
https://read.qxmd.com/read/38298797/functional-connectivity-mechanisms-underlying-symptom-reduction-following-lisdexamfetamine-treatment-in-binge-eating-disorder-a-clinical-trial
#37
JOURNAL ARTICLE
Kristi R Griffiths, Isabella A Breukelaar, Grace Harvie, Jenny Yang, Sheryl L Foster, Anthony W Harris, Simon Clarke, Phillipa J Hay, Stephen Touyz, Mayuresh S Korgaonkar, Michael R Kohn
BACKGROUND: Speculation exists as to whether lisdexamfetamine dimesylate (LDX) acts on the functional connectivity (FC) of brain networks that modulate appetite, reward, or inhibitory control in binge-eating disorder (BED). Better insights into its action may help guide the development of more targeted therapeutics and identify who will benefit most from this medication. Here, we use a comprehensive data-driven approach to investigate the brain FC changes that underlie the therapeutic action of LDX in patients with BED...
January 2024: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/38294173/effects-of-30%C3%A2-days-bed-rest-and-exercise-countermeasures-on-pbmc-bioenergetics
#38
JOURNAL ARTICLE
F-M Buescher, M T Schmitz, T Frett, J Kramme, L de Boni, E M Elmenhorst, E Mulder, S Moestl, K Heusser, P Frings-Meuthen, J Jordan, J Rittweger, D Pesta
AIM: Altered mitochondrial function across various tissues is a key determinant of spaceflight-induced physical deconditioning. In comparison to tissue biopsies, blood cell bioenergetics holds promise as a systemic and more readily accessible biomarker, which was evaluated during head-down tilt bed rest (HDTBR), an established ground-based analog for spaceflight-induced physiological changes in humans. More specifically, this study explored the effects of HDTBR and an exercise countermeasure on mitochondrial respiration in peripheral blood mononuclear cells (PBMCs)...
January 31, 2024: Acta Physiologica
https://read.qxmd.com/read/38290228/severe-starvation-and-restraint-in-a-47-year-old-woman-clinical-autopsy-and-histopathological-evidence-of-abuse-and-neglect
#39
Giorgia Franchetti, Clara Cestonaro, Renzo Giordano, Enrica Callegari, Chiara Giraudo, Guido Viel, Giovanni Cecchetto
The recognition of abuse and/or neglect still represents a challenge for both clinicians and forensic pathologists. Whereas abusive behaviors have been largely described among pediatric and elderly populations, adults' abuse and neglect is less frequently encountered, and therefore investigated. We report a case of a middle-aged woman without any known organic or psychiatric disorders who died of a multiple organ failure (MOF) due to extreme cachexia and bed-resting syndrome. The integration of all clinical, autopsy and histopathological data highlighted a picture of severe malnutrition, restraint, and widespread traumatic injuries related to abuse and neglect...
January 17, 2024: Forensic Science International
https://read.qxmd.com/read/38287376/comparison-of-safety-and-efficacy-of-posterior-lumbar-interbody-fusion-plif-and-modified-transforaminal-lumbar-interbody-fusion-m-tlif-in-the-treatment-of-single-segment-lumbar-degenerative-diseases
#40
JOURNAL ARTICLE
Ming Chen, Jianchao Cui, Youtao Liu, Zhuoyan Cai, Cekai Yang, Hao Liu, Yuan Chen, Zhensong Yao
OBJECTIVE: To compare modified transforaminal lumbar interbody fusion (M-TLIF) with posterior lumbar interbody fusion (PLIF) in the treatment of single-segment lumbar degenerative disorders in order to assess its safety and effectiveness. METHODS: From January 2016 to January 2021, 74 patients who received single-segment M-TLIF were examined. A total of 74 patients having single-segment PLIF during the same time period were included in a retrospective controlled study using the same inclusion and exclusion criteria...
January 30, 2024: Journal of Orthopaedic Surgery and Research
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