keyword
https://read.qxmd.com/read/38487016/extensive-dynamic-changes-in-the-human-transcriptome-and-its-circadian-organization-during-prolonged-bed-rest
#1
JOURNAL ARTICLE
Simon N Archer, Carla Möller-Levet, María-Ángeles Bonmatí-Carrión, Emma E Laing, Derk-Jan Dijk
Physiological and molecular processes including the transcriptome change across the 24-h day, driven by molecular circadian clocks and behavioral and systemic factors. It is not known how the temporal organization of the human transcriptome responds to a long-lasting challenge. This may, however, provide insights into adaptation, disease, and recovery. We investigated the human 24-h time series transcriptome in 20 individuals during a 90-day constant bed rest protocol. We show that the protocol affected 91% of the transcriptome with 76% of the transcriptome still affected after 10 days of recovery...
March 15, 2024: IScience
https://read.qxmd.com/read/38477590/kinetic-modeling-analysis-of-ar-addition-to-atmospheric-pressure-n-2-h-2-plasma-for-plasma-assisted-catalytic-synthesis-of-nh-3
#2
JOURNAL ARTICLE
Zihan Lin, Shota Abe, Zhe Chen, Surabhi Jaiswal, Bruce E Koel
Zero-dimensional kinetic modeling of atmospheric pressure Ar-N2 -H2 nonthermal plasma was carried out to gain mechanistic insights into plasma-assisted catalytic synthesis of ammonia. Ar dilution is a common technique for tailoring plasma discharge properties and has been shown to enhance NH3 formation when added to N2 -H2 plasma. The kinetic model was developed for a coaxial dielectric barrier discharge quartz wool-packed bed reactor operating at near room temperature using a kHz-frequency plasma source. With 30% Ar mixed in a 1:1 N2 -H2 plasma at 760 Torr, we find that NH3 production is dominated by Eley-Rideal (E-R) surface reactions, which heavily involve surface NH x species derived from N and H radicals in the gas phase, while the influence of excited N2 molecules is negligible...
March 13, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38477070/experimental-bed-rest-as-a-model-to-investigate-mechanisms-of-and-countermeasures-against-microgravity-and-disease-free-inactivity
#3
JOURNAL ARTICLE
Rodrigo Fernandez-Gonzalo, Colleen S Deane, Damian Bailey
No abstract text is available yet for this article.
March 13, 2024: Experimental Physiology
https://read.qxmd.com/read/38468299/segmental-artery-angioembolization-as-an-efficient-treatment-modality-for-delayed-hematuria-with-normal-angiography-two-case%C3%A2-reports
#4
JOURNAL ARTICLE
Alireza Pakdel, Fardin Asgari, Razman Arabzadeh Bahri, Seyed Mohammad Kazem Aghamir
BACKGROUND: Percutaneous nephrolithotomy is the most commonly used modality for the removal of kidney stones larger than 2 cm in size. Like other stone removal methods, percutaneous nephrolithotomy also has some complications, including bleeding and delayed hematuria. These complications are improved with conservative management and bed rest most of the time. However, it may require more invasive treatments. Angioembolization following an abnormal renal angiography is an efficient treatment modality for delayed hematuria...
March 12, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38461309/nephrotic-syndrome-with-rectus-sheath-hematoma-a-case-report
#5
JOURNAL ARTICLE
Ai Fujii, Yuto Matsuda, Tomohisa Yabe, Hayashi Norifumi, Keiji Fujimoto, Masahide Yamazaki, Hitoshi Yokoyama, Kengo Furuichi
BACKGROUND: Rectus sheath hematoma is a rare presentation often associated with abdominal trauma and anticoagulant therapy. Here, we present a patient with severe rectus sheath hematoma accompanied by nephrotic syndrome who achieved significant clinical improvement without the need for invasive treatment. CASE PRESENTATION: A 72-year-old Japanese woman was referred to our hospital for the treatment of nephrotic syndrome. She was receiving steroid and anticoagulant therapy...
March 10, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38460465/patient-centered-mild-traumatic-brain-injury-interventions-in-the-emergency-department
#6
REVIEW
Sarah Ray, Jude Luke, Natalie Kreitzer
INTRODUCTION: Traumatic brain injury (TBI) results in 2.5 million emergency department (ED) visits per year in the US, with mild traumatic brain injury (mTBI) accounting for 90% of cases. There is considerable evidence that many experience chronic symptoms months to years later. This population is rarely represented in interventional studies. Management of adult mTBI in the ED has remained unchanged, without consensus of therapeutic options. The aim of this review was to synthesize existing literature of patient-centered ED treatments for adults who sustain an mTBI, and to identify practices that may offer promise...
March 5, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38438929/carbohydrate-ingestion-does-not-suppress-increases-in-fatty-acid-binding-protein-4-concentrations-post-acute-aerobic-exercise-in-healthy-men-a-randomized-crossover-study
#7
JOURNAL ARTICLE
Shigeharu Numao, Ryota Uchida, Takashi Kurosaki, Masaki Nakagaichi
BACKGROUND: Fatty acid-binding protein 4 (FABP4) has been associated with cardiovascular disease and diabetes. Acute aerobic exercise increases circulating FABP4 concentrations, but the underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of inhibition of lipolysis by carbohydrate ingestion on circulating FABP4 concentrations during and after acute aerobic exercise in healthy men. METHODS: Men aged between 20 and 40, with no exercise habits and no metabolic diseases, were recruited...
March 4, 2024: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/38435665/comparative-evaluation-of-nebulised-dexmedetomidine-vs-fentanyl-for-the-treatment-of-post-dural-puncture-headache-pdph-in-parturients-after-caesarean-section-under-spinal-anaesthesia-a-randomised-controlled-study
#8
JOURNAL ARTICLE
Amarjeet Kumar, Chandni Sinha, Kunal Singh, Monika Anant, Ajeet Kumar, Poonam Kumari
BACKGROUND AND AIMS: The incidence of post-dural puncture headache (PDPH) following spinal anaesthesia in the obstetric population is around 0.5%-2%. Hydration, bed rest, caffeine, paracetamol, non-steroid anti-inflammatory drugs, epidural blood patches, etc., are the various modalities used for its management. This study aims to compare nebulised dexmedetomidine versus fentanyl for the treatment of PDPH in parturients after caesarean section under spinal anaesthesia. METHODS: Ninety obstetric patients aged 18-35 years with American Society of Anesthesiologists (ASA) physical status II/III and suffering from PDPH as per the criteria of the International Headache Society after caesarean section under spinal anaesthesia were recruited in this double-blinded randomised study...
February 2024: Indian Journal of Anaesthesia
https://read.qxmd.com/read/38429289/dynamic-changes-in-perivascular-space-morphology-predict-signs-of-spaceflight-associated-neuro-ocular-syndrome-in-bed-rest
#9
JOURNAL ARTICLE
Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino
During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major limitation to our understanding of the changes in brain structure and physiology induced by spaceflight stems from the logistical difficulties of studying astronauts. The current study aimed to determine whether PVS changes also occur on Earth with the spaceflight analog head-down tilt bed rest (HDBR). We examined how the number and morphology of magnetic resonance imaging-visible PVS (MV-PVS) are affected by HDBR with and without elevated carbon dioxide (CO2 )...
March 1, 2024: NPJ Microgravity
https://read.qxmd.com/read/38424716/the-effect-of-protein-or-amino-acid-provision-on-immobilization-induced-muscle-atrophy-in-healthy-adults-a-systematic-review-and-meta-analysis
#10
REVIEW
Alix K Hughes, Thomas Francis, Jessica Rooney, Ross Pollock, Oliver C Witard
Bed rest and limb immobilization are models of muscle disuse associated with skeletal muscle atrophy and reduced strength. The purpose of this systematic review was to examine the impact of protein or amino acid provision before and/or during a period of muscle disuse on muscle atrophy (primary outcome), strength and muscle protein synthesis (secondary outcomes) following a disuse period. We performed a systematic review of Embase, MEDLINE, Web of Science, PubMed and Clinical Trials in December 2022. Eligible studies were randomized controlled trials that combined a dietary protein or amino acid intervention versus control during an experimental model of disuse (bed rest or unilateral limb immobilization) in healthy individuals aged ≥18 years...
February 29, 2024: Experimental Physiology
https://read.qxmd.com/read/38414076/lessons-from-an-elderly-patient-with-pulmonary-embolism-caused-by-protein-s-deficiency-a-case-report
#11
JOURNAL ARTICLE
Liu Qiang, Li Hong, Shen Min, Wang Hongping, Chen Xian, Li Tianlang
BACKGROUND: Lower limb deep vein thrombosis (DVT) concurrent with pulmonary embolism (PE) is perilous, particularly in the elderly, exhibiting heterogeneity with thrombophilia mutations. Tailored treatment is essential, yet sudden deaths complicate causative factor elucidation. This report emphasizes genetic testing necessity in PE patients with thrombophilia indicators, facilitating cause identification, personalized treatment guidance, and family education. CASE PRESENTATION: This study details a 75-year-old Chinese woman with DVT and PE, where genetic testing identified thrombophilia, guiding personalized treatment decisions...
February 28, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38411283/daily-blood-flow-restriction-does-not-preserve-muscle-mass-and-strength-during-2%C3%A2-weeks-of-bed-rest
#12
JOURNAL ARTICLE
Cas J Fuchs, Wesley J H Hermans, Jean Nyakayiru, Michelle E G Weijzen, Joey S J Smeets, Thorben Aussieker, Joan M Senden, Will K H W Wodzig, Tim Snijders, Lex B Verdijk, Luc J C van Loon
We measured the impact of blood flow restriction on muscle protein synthesis rates, muscle mass and strength during 2 weeks of strict bed rest. Twelve healthy, male adults (age: 24 ± 3 years, body mass index: 23.7 ± 3.1 kg/m2 ) were subjected to 14 days of strict bed rest with unilateral blood flow restriction performed three times daily in three 5 min cycles (200 mmHg). Participants consumed deuterium oxide and we collected blood and saliva samples throughout 2 weeks of bed rest...
February 27, 2024: Journal of Physiology
https://read.qxmd.com/read/38395902/improving-management-of-ards-uniting-acute-management-and-long-term-recovery
#13
REVIEW
Nicola Latronico, M Eikermann, E W Ely, D M Needham
Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disability for months to years after hospitalization. These findings underscore the importance of extended follow-up to assess and address the Post-Intensive Care Syndrome (PICS), characterized by persistent impairments in physical, cognitive, and/or mental health status that impair quality of life over the long-term...
February 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38394375/methods-of-sampling-malaria-vectors-and-their-reliability-in-estimating-entomological-indices-in-africa
#14
JOURNAL ARTICLE
Teshome Degefa, Delenasaw Yewhalaw, Guiyun Yan
In efforts to intensify malaria control through vector control and hasten the progress towards elimination, the impact of control interventions needs to be evaluated. This requires sampling vector population using appropriate trapping methods. The aim of this article is to critically review methods of sampling malaria vectors and their reliability in estimating entomological indicators of malaria transmission in Africa. The standard methods are human landing catch (HLC), pyrethrum spray catch, and pit shelter for sampling host-seeking, indoor resting, and outdoor resting malaria vectors, respectively...
February 23, 2024: Journal of Medical Entomology
https://read.qxmd.com/read/38392959/the-effects-of-intensive-rehabilitation-combined-with-thiamine-treatment-on-cognitive-recovery-in-a-case-of-non-alcoholic-wernicke-korsakoff-syndrome
#15
Cinzia Palmirotta, Gilda Turi, Serena Tagliente, Michele Pansini, Stefania De Trane, Gianvito Lagravinese
Wernicke-Korsakoff Syndrome (WKS) is a severe neurological disorder resulting from thiamine deficiency, commonly associated with alcohol consumption but also stemming from dietary imbalances or other clinical conditions. Cognitive deficits, affecting memory and executive functions, pose a serious concern, with partial recovery often not complete. A 28-year-old woman underwent surgery for acute necrotizing hemorrhagic pancreatitis, leading to admission for post-acute intensive treatment due to prolonged bed rest syndrome...
February 14, 2024: Neurology International
https://read.qxmd.com/read/38390278/a-case-report-of-a-child-with-pulmonary-hypertension-associated-with-sars-cov-2-infection
#16
Kentaro Okunushi, Hironobu Kobayashi, Yuri Yoh, Masaya Kunimatsu, Tadashi Shiohama, Tomozumi Takatani, Hiromichi Hamada
We encountered a pediatric case of pulmonary hypertension triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 14-year-old girl was brought to the emergency department of our hospital with fever, respiratory distress, and impaired consciousness. She tested positive for SARS-CoV-2 upon a polymerase chain reaction examination and had prolonged hypoxemia without pneumonia. An echocardiography revealed elevated right ventricular pressure. She was diagnosed with pilocytic astrocytoma at the age of 10 years and underwent a resection of a pituitary tumor...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38388893/analgesic-effect-of-the-ultrasound-guided-thoracolumbar-paravertebral-block-in-patients-undergoing-robot-assisted-laparoscopic-nephrectomy-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Guojiang Yin, Yue Li, Pengxiao Wei, Xuyuan Ma, Bixi Li, Guosheng Gan, Xiaoyang Song
BACKGROUND: Paravertebral block has similar effect as epidural anesthesia, and has good somatic and visceral analgesic effect. Paravertebral block is widely used in thoracic surgery, but rarely used in abdominal surgery. AIMS: This study aimed to evaluate the analgesic effect of thoracolumbar paravertebral block in patients undergoing robot-assisted laparoscopic nephrectomy. METHODS: One hundred patients undergoing elective robot-assisted laparoscopic nephrectomy were included in this study...
February 22, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38381267/unintended-dural-tears-during-unilateral-biportal-endoscopic-lumbar-surgery-incidence-and-risk-factors
#18
JOURNAL ARTICLE
Hang Yu, Qingzhong Zhao, Jianwei Lv, Jianjun Liu, Bin Zhu, Lei Chen, Juehua Jing, Dasheng Tian
BACKGROUND: An unintended dural tear (DT) is the most common intraoperative complication of lumbar spine surgery. The unilateral biportal endoscopic technique (UBE) has become increasingly popular for treating various degenerative diseases of the lumbar spine; however, the DT incidence and risk factors specific to UBE remain undetermined. Therefore, this study aimed to evaluate the incidence and risk factors of DTs in UBE. METHOD: Data from all patients who underwent UBE for degenerative lumbar spinal diseases from November 2018 to December 2021 at our institution were used to assess the effects of demographics, diagnosis, and type of surgery on unintended DT risk...
February 21, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38378626/body-lice-a-vector-for-re-emerging-disease-outbreak-in-a-rehabilitation-camp-in-northwestern-iran
#19
JOURNAL ARTICLE
Esmail Ghorbani, Eslam Moradi-Asl, Mustapha Ahmed Yusuf
OBJECTIVE: The report of the outbreak of body louse in northwestern Iran after three decades reminds us again of the danger of the re-emerging of previous epidemics. RESULTS: The results of the study that nearly 70% of the patients in a rehabilitation Centre were infected with body louse. In this study, scientific measures were taken to prevent the spread of body lice to healthy people, including isolation of the patients, washing the clothes of those infected at high temperatures, and spraying the rest area, beddings, and blankets...
February 20, 2024: BMC Research Notes
https://read.qxmd.com/read/38369183/role-of-splanchnic-circulation-in-the-pathogenesis-of-heart-failure-state-of-the-art-review
#20
REVIEW
Hidenori Yaku, Marat Fudim, Sanjiv J Shah
A hallmark of heart failure (HF), whether it presents itself during rest or periods of physical exertion, is the excessive elevation of intracardiac filling pressures at rest or with exercise. Many mechanisms contribute to the elevated intracardiac filling pressures, and notably, the concept of volume redistribution has gained attention as a cause of the elevated intracardiac filling pressures in patients with HF, particularly HF with preserved ejection fraction, who often present without symptoms at rest, with shortness of breath and fatigue appearing only during exertion...
February 17, 2024: Journal of Cardiology
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