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polymeric membrane dressings

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https://www.readbyqxmd.com/read/29019391/fibrous-nanozyme-dressings-with-catalase-like-activity-for-h2o2-reduction-to-promote-wound-healing
#1
Minghan Hu, Karsten Korschelt, Phillip Daniel, Katharina Landfester, Wolfgang Tremel, Markus B Bannwarth
The concentrations of the redox pair hydrogen peroxide (H2O2) and oxygen (O2) can promote or decelerate the progression and duration of the wound healing process. Although H2O2 can reach critically high concentrations and prohibit healing, a sufficient O2 inflow to the wound is commonly desired. Herein, we describe the fabrication and use of a membrane that can contemptuously decrease H2O2 and increase O2 levels. Therefore, hematite nanozyme particles were integrated into electrospun and cross-linked poly(vinyl alcohol) membranes...
October 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28875763/porosity-effects-of-natural-latex-hevea-brasiliensis-on-release-of-compounds-for-biomedical-applications
#2
M C R Miranda, F G Prezotti, F A Borges, N R Barros, B S F Cury, R D Herculano, E M Cilli
Natural rubber latex biomedical (NRLb) obtained from the rubber tree Hevea brasiliensis has shown great potential in biomedicine and biomaterial applications. NRLb has been utilized as a physical barrier against infectious agents and in the controlled release of drugs and extracts. In the present work, NRLb was polymerized in a lyophilizer using different volumes of water to control the resultant membrane porosity and characterized regarding the surface morphology, water vapour permeability (WVP), mechanical properties, haemolytic activity and cytotoxicity...
September 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28851645/superabsorbent-crosslinked-carboxymethyl-cellulose-peg-hydrogels-for-potential-wound-dressing-applications
#3
Nádia S V Capanema, Alexandra A P Mansur, Anderson C de Jesus, Sandhra M Carvalho, Luiz C de Oliveira, Herman S Mansur
This study focused on the synthesis and comprehensive characterization of environmentally friendly hydrogel membranes based on carboxymethyl cellulose (CMC) for wound dressing and skin repair substitutes. These new CMC hydrogels were prepared with two degrees of functionalization (DS=0.77 and 1.22) and chemically crosslinked with citric acid (CA) for tuning their properties. Additionally, CMC-based hybrids were prepared by blending with polyethylene glycol (PEG, 10wt.%). The results demonstrated that superabsorbent hydrogels (SAP) were produced with swelling degree typically ranging from 100% to 5000%, which was significantly dependent on the concentration of CA crosslinker and the addition of PEG as network modifier...
August 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28676002/recent-advances-in-polymer-based-wound-dressings-for-the-treatment-of-diabetic-foot-ulcer-an-overview-of-state-of-the-art
#4
Zahid Hussain, Hnin Ei Thu, Ahmad Nazrun Shuid, Haliza Katas, Fahad Hussain
Diabetic foot ulcers (DFUs) are the chronic, non-healing complications of diabetic mellitus which compels a significant burden to the patients and the healthcare system. Peripheral vascular disease, diabetic neuropathy, and abnormal cellular and cytokine/chemokine activity are among the prime players which exacerbate the severity and prevent wound reapir. Unlike acute wounds, DFUs impose a substantial challenge to the conventional wound dressings and demand the development of novel and advanced wound healing modalities...
July 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28407434/spatiotemporal-characterization-of-hydration-process-of-asymmetric-polymeric-wound-dressings-for-decubitus-ulcers
#5
Anna Górska, Przemyslaw Dorożyński, Władysław P Węglarz, Krzysztof Jasiński, Mateusz Kurek, Renata Jachowicz, Jolanta Klaja, Piotr Kulinowski
Pressure ulcers belong to the most chalenging clinical problems. As hydration level of such wounds is important for optimal healing, preparation of new wound dressing (WD) materials for pressure ulcers requires thorough in vitro evaluation as prerequisite to final in vivo testing. The aims of the study were to: (a) develop a simple method of preparation of asymmetric polymeric membrane, (b) to propose a set of in vitro methods for membrane characterization during hydration. A polyvinyl alcohol asymmetric membrane with homogeneous skin layer and porous spongy layer was developed with nonadhesive properties and ability to absorb and retain the water...
April 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28386852/polyurethane-siloxane-membranes-containing-graphene-oxide-nanoplatelets-as-antimicrobial-wound-dressings-in-vitro-and-in-vivo-evaluations
#6
Elias Shams, Hamid Yeganeh, Hossein Naderi-Manesh, Reza Gharibi, Zuhair Mohammad Hassan
Preserving wounds from bacterial and fungal infections and retaining optimum moist environment over damaged tissue are major challenges in wound care management. Application of wound dressings with antimicrobial activity and appropriate wound exudates handling ability is of particular significance for promoting wound healing. To this end, preparation and evaluation of novel wound dres1sings made from polyurethane/siloxane network containing graphene oxide (GO) nanoplatelets are described. The particular sol-gel hydrolysis/condensation procedure applied for the preparation of dressings leads to an appropriate distribution of GO nanoplatelets in the dressing membranes...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28239493/a-review-on-polymeric-hydrogel-membranes-for-wound-dressing-applications-pva-based-hydrogel-dressings
#7
REVIEW
Elbadawy A Kamoun, El-Refaie S Kenawy, Xin Chen
This review presents the past and current efforts with a brief description on the featured properties of hydrogel membranes fabricated from biopolymers and synthetic ones for wound dressing applications. Many endeavors have been exerted during past ten years for developing new artificial polymeric membranes, which fulfill the demanded conditions for the treatment of skin wounds. This review mainly focuses on representing specifications of ideal polymeric wound dressing membranes, such as crosslinked hydrogels compatible with wound dressing purposes...
May 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28060006/resolving-epibole-with-polymeric-membrane-dressings-in-home-care
#8
Kimberly S Bare, Jerri Drain
BACKGROUND: The management of chronic (nonhealing) wounds with epibole is challenging and costly, especially when the problem is not promptly identified or the patient is intolerant to conventional treatments. CASE DESCRIPTION: We describe the use of a polymeric membrane dressing (PMD) in 3 patients with chronic (nonhealing) wounds and epibole who were unable to be treated with traditional interventions such as silver nitrate or sharp debridement. Patient 1 was a 51 year-old male with a right foot stasis ulcer with 60% fibrin/slough to the wound bed, patient 2 was a 58-year-old female with a stage 4 pressure injury of the left hip with undermining, and patient 3 was a 62-year-old female with a dehisced abdominal surgical wound...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27842818/antibacterial-activity-and-cytocompatibility-of-chitooligosaccharide-modified-polyurethane-membrane-via-polydopamine-adhesive-layer
#9
Chuang Luo, Wenjun Liu, Binghong Luo, Jinhuan Tian, Wei Wen, Mingxian Liu, Changren Zhou
The aim of this study was to provide a convenient surface modification method for polyurethane (PU) membrane and evaluate its influence on hydrophilicity, antibacterial activity and cell functions, which are the most important factors for wound dressings. For this purpose, chitooligosaccharide (COS) was modified onto the surface of PU membrane based on the self-polymerization of dopamine (DOPA). Surface composition, morphology, hydrophilicity and surface energy of the original and modified PU membranes were characterized...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27356145/polymeric-membrane-dressings-for-topical-wound-management-of-patients-with-infected-wounds-in-a-challenging-environment-a-protocol-with-3-case-examples
#10
Linda L Benskin
Patients with acute wounds often delay seeking medical assistance until an incapacitating infection has developed. When such patients come for help at a remote Christian clinic in northern Ghana, West Africa, the goals of care are to resolve and prevent a return of infection, decrease pain, enable an immediate return to normal activities, and facilitate healing. Because the local protocol of care, Edinburgh University Solution of Lime (EUSOL)-soaked gauze, did not meet these goals, the author tried using a variety of donated wound dressing regimens...
June 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27345136/choline-phosphate-functionalized-cellulose-membrane-a-potential-hemostatic-dressing-based-on-a-unique-bioadhesion-mechanism
#11
Xiaoqiang Yang, Na Li, Iren Constantinesco, Kai Yu, Jayachandran N Kizhakkedathu, Donald E Brooks
UNLABELLED: Wound dressings are a key component in provision of optimal conditions for bleeding control and wound healing. For absorbent dressings, electrostatic interactions are frequently utilized as one of the mechanisms driving dressing adhesion. Herein, a choline phosphate functionalized biocompatible cellulose membrane that can efficiently arrest human red blood cells was developed to have potential application in wound dressing. The bioadhesion is based on the unique multivalent electrostatic interaction between the head groups of phosphatidyl choline based lipids on the cell membrane and its inverse orientation but virtually identical structure, choline phosphate, coupled to the cellulose membrane...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27313054/randomized-controlled-trial-comparing-the-combination-of-a-polymeric-membrane-dressing-plus-negative-pressure-wound-therapy-against-negative-pressure-wound-therapy-alone-the-wicvac-study
#12
Edda Skrinjar, Nikolaus Duschek, Gottfried S Bayer, Ojan Assadian, Spyridon Koulas, Kornelia Hirsch, Jelena Basic, Afshin Assadian
Negative pressure wound therapy (NPWT) is the treatment of choice for chronic wounds; yet, it is associated with considerable workload. Prompted by its nonadhesive and wound-healing properties, this study investigated the effect of an additional polymeric membrane interface dressing (PMD; PolyMem WIC) in NPWT. From October 2011 to April 2013, 60 consecutive patients with chronic leg wounds or surgical site infections after revascularization of lower extremities were randomly allocated to either treatment with conventional NPWT (control arm) or NPWT with an additional PMD (intervention arm)...
June 16, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/26492095/prototype-development-of-the-intelligent-hydrogel-wound-dressing-and-its-efficacy-in-the-detection-of-model-pathogenic-wound-biofilms
#13
N T Thet, D R Alves, J E Bean, S Booth, J Nzakizwanayo, A E R Young, B V Jones, A Toby A Jenkins
The early detection of wound infection in situ can dramatically improve patient care pathways and clinical outcomes. There is increasing evidence that within an infected wound the main bacterial mode of living is a biofilm: a confluent community of adherent bacteria encased in an extracellular polymeric matrix. Here we have reported the development of a prototype wound dressing, which switches on a fluorescent color when in contact with pathogenic wound biofilms. The dressing is made of a hydrated agarose film in which the fluorescent dye containing vesicles were mixed with agarose and dispersed within the hydrogel matrix...
June 22, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26251319/bacterial-response-to-different-surface-chemistries-fabricated-by-plasma-polymerization-on-electrospun-nanofibers
#14
Martina Abrigo, Peter Kingshott, Sally L McArthur
Control over bacterial attachment and proliferation onto nanofibrous materials constitutes a major challenge for a variety of applications, including filtration membranes, protective clothing, wound dressings, and tissue engineering scaffolds. To develop effective devices, the interactions that occur between bacteria and nanofibers with different morphological and physicochemical properties need to be investigated. This paper explores the influence of fiber surface chemistry on bacterial behavior. Different chemical functionalities were generated on the surface of electrospun polystyrene nanofibers through plasma polymerization of four monomers (acrylic acid, allylamine, 1,7-octadiene, and 1,8-cineole)...
2015: Biointerphases
https://www.readbyqxmd.com/read/25382131/polymeric-membrane-dressing-for-radiotherapy-induced-skin-reactions
#15
Fionnula Hegarty, Michelle Wong
Post-radiotherapy treatment depends on how the skin within the treatment field has reacted during radiotherapy for cancer. Skin reactions can range from mild dull erythema and tightening of the skin to severe moist desquamation, which may result in wounds that can be painful and sloughy. It is estimated that approximately 87% of patients will experience a moderate-to-severe skin reaction. This article discusses an evaluation of the use of a polymeric membrane dressing (PolyMem®, Aspen Medical) in 23 patients with skin reactions following radiotherapy...
November 2014: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/25280679/electrospun-propolis-polyurethane-composite-nanofibers-for-biomedical-applications
#16
Jeong In Kim, Hem Raj Pant, Hyun-Jaung Sim, Kang Min Lee, Cheol Sang Kim
Tissue engineering requires functional polymeric membrane for adequate space for cell migration and attachment within the nanostructure. Therefore, biocompatible propolis loaded polyurethane (propolis/PU) nanofibers were successfully prepared using electrospinning of propolis/PU blend solution. Here, composite nanofibers were subjected to detailed analysis using electron microscopy, FT-IR spectroscopy, thermal gravimetric analysis (TGA), and mechanical properties and water contact angle measurement. FE-SEM images revealed that the composite nanofibers became point-bonded with increasing amounts of propolis in the blend due to its adhesive properties...
November 2014: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/24851807/polymeric-membrane-dressings-for-radiotherapy-induced-skin-damage
#17
Audrey Scott
Radiotherapy is one of the mainline treatments for cancer. One of the side effects associated with radiotherapy includes skin problems, which range from mild (dull erythema and tightening of the skin) to severe (moist desquamation resulting in open wounds that can be very painful associated with sloughy and, in some severe cases, necrosis). The increased use of advanced radical treatments, such as intensity-modulated radiotherapy treatment (IMRT), can also result in a higher number of patients experiencing skin reactions...
May 22, 2014: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/24527278/polymem-%C3%A2-wic-%C3%A2-silver-%C3%A2-rope-a-multifunctional-dressing-for-decreasing-pain-swelling-and-inflammation
#18
Linda L L Benskin
PROBLEM: Choosing the most appropriate dressing to meet the complex needs of patients with narrow deep wounds, such as tunnels, fistulas, and cysts, is a daunting task. Such wounds are difficult to cleanse and tend to be extremely painful. Wound patients need a drug-free dressing that handles exudates, decreases the need for traumatic cleansing during dressing changes, and addresses wound pain, inflammation, and swelling. SOLUTION: Multifunctional PolyMem(®) dressings (the generic name is polymeric membrane dressings) contain ingredients that work synergistically to continuously cleanse wounds and bring about rapid healing...
February 2012: Advances in Wound Care
https://www.readbyqxmd.com/read/24522948/bioinspired-porous-membranes-containing-polymer-nanoparticles-for-wound-healing
#19
Ana M Ferreira, Clara Mattu, Elia Ranzato, Gianluca Ciardelli
Skin damages covering a surface larger than 4 cm(2) require a regenerative strategy based on the use of appropriate wound dressing supports to facilitate the rapid tissue replacement and efficient self-healing of the lost or damaged tissue. In the present work, A novel biomimetic approach is proposed for the design of a therapeutic porous construct made of poly(L-lactic acid) (PLLA) fabricated by thermally induced phase separation (TIPS). Biomimicry of ECM was achieved by immobilization of type I collagen through a two-step plasma treatment for wound healing...
December 2014: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/23795955/surface-zwitterionization-of-expanded-poly-tetrafluoroethylene-membranes-via-atmospheric-plasma-induced-polymerization-for-enhanced-skin-wound-healing
#20
Jheng-Fong Jhong, Antoine Venault, Chun-Chung Hou, Sheng-Han Chen, Ta-Chin Wei, Jie Zheng, James Huang, Yung Chang
Development of bioinert membranes to prevent blood clotting, tissue adhesion, and bacterial attachment is important for the wound healing process. In this work, two wound-contacting membranes of expanded poly(tetrafluoroethylene) (ePTFE) grafted with zwitterionic poly(sulfobetaine methacrylate) (PSBMA) and hydrophilic poly(ethylene glycol) methacrylate (PEGMA) via atmospheric plasma-induced surface copolymerization were studied. The surface grafting chemical structure, hydrophilicity, and hydration capability of the membranes were determined to illustrate the correlations between bioadhesive properties and wound recovery of PEGylated and zwitterionic ePTFE membranes...
July 24, 2013: ACS Applied Materials & Interfaces
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