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Northern Manhattan Study

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https://www.readbyqxmd.com/read/29103864/apolipoprotein-e-gene-polymorphism-and-subclinical-carotid-atherosclerosis-the-northern-manhattan-study
#1
Brett Doliner, Chuanhui Dong, Susan H Blanton, Hannah Gardener, Mitchell S V Elkind, Ralph L Sacco, Ryan T Demmer, Moise Desvarieux, Tatjana Rundek
BACKGROUND: Apolipoprotein E (APOE) polymorphism has previously been associated with carotid intima-media thickness (cIMT) in predominantly Caucasian populations. We sought to test the strength of the relationship between APOE-ε4 carrier status and subclinical atherosclerosis in a tri-ethnic population with a large Hispanic representation. METHODS: We assessed the association between APOE polymorphism and cIMT and plaque burden among 1243 stroke-free individuals (mean age 69 years, 65% Hispanic, 18% black, 17% white) using a sequence of multivariable regression models...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29018136/dietary-sodium-to-potassium-ratio-and-risk-of-stroke-in-a-multiethnic-urban-population-the-northern-manhattan-study
#2
MULTICENTER STUDY
Joshua Willey, Hannah Gardener, Sandino Cespedes, Ying K Cheung, Ralph L Sacco, Mitchell S V Elkind
BACKGROUND AND PURPOSE: There is growing evidence that increased dietary sodium (Na) intake increases the risk of vascular diseases, including stroke, at least in part via an increase in blood pressure. Higher dietary potassium (K), seen with increased intake of fruits and vegetables, is associated with lower blood pressure. The goal of this study was to determine the association of a dietary Na:K with risk of stroke in a multiethnic urban population. METHODS: Stroke-free participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were followed-up for incident stroke...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28984588/secular-trends-in-the-incidence-of-dementia-in-a-multi-ethnic-community
#3
James M Noble, Nicole Schupf, Jennifer J Manly, Howard Andrews, Ming-Xin Tang, Richard Mayeux
BACKGROUND: Determination of secular trends in cognitive aging is important for prioritization of resources, services, and research in aging populations. Prior studies have identified declining dementia incidence associated with changes in cardiovascular risk factors and increased educational attainment. However, few studies have examined these factors in multi-ethnic cohorts. OBJECTIVE: To identify secular trends in the incidence rate of dementia in an elderly population...
October 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28975155/genome-wide-scan-in-hispanics-highlights-candidate-loci-for-brain-white-matter-hyperintensities
#4
Ashley Beecham, Chuanhui Dong, Clinton B Wright, Nicole Dueker, Adam M Brickman, Liyong Wang, Charles DeCarli, Susan H Blanton, Tatjana Rundek, Richard Mayeux, Ralph L Sacco
OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population. METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights-Inwood Columbia Aging Project...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28970793/differential-effect-of-left-vs-right-white-matter-hyperintensity-burden-on-functional-decline-the-northern-manhattan-study
#5
Mandip S Dhamoon, Ying-Kuen Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
Asymmetry of brain dysfunction may disrupt brain network efficiency. We hypothesized that greater left-right white matter hyperintensity volume (WMHV) asymmetry was associated with functional trajectories. Methods: In the Northern Manhattan Study, participants underwent brain MRI with axial T1, T2, and fluid attenuated inversion recovery sequences, with baseline interview and examination. Volumetric WMHV distribution across 14 brain regions was determined separately by combining bimodal image intensity distribution and atlas based methods...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28944291/acceptability-of-chairside-screening-for-racial-ethnic-minority-older-adults-a-qualitative-study
#6
A P Greenblatt, I Estrada, E W Schrimshaw, S S Metcalf, C Kunzel, M E Northridge
An aging and more racially and ethnically diverse population, coupled with changes in the health care policy environment, is demanding that the dental profession both redirect and expand its focus. Challenges include providing comprehensive care for patients with complicated medical needs while improving access to care for underserved groups. The purpose of this study is to examine the acceptability of screening for hypertension and diabetes in the dental setting for African American, Puerto Rican, and Dominican older adults who attend senior centers in northern Manhattan, New York City...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28810247/physical-inactivity-predicts-slow-gait-speed-in-an-elderly-multi-ethnic-cohort-study-the-northern-manhattan-study
#7
Joshua Z Willey, Yeseon P Moon, Erin R Kulick, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind
INTRODUCTION: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. METHODS: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test...
2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28704175/age-related-differences-in-antihypertensive-medication-adherence-in-hispanics-a-cross-sectional-community-based-survey-in-new-york-city-2011-2012
#8
Priti Bandi, Emily Goldmann, Nina S Parikh, Parisa Farsi, Bernadette Boden-Albala
INTRODUCTION: US Hispanics, particularly younger adults in this population, have a higher prevalence of uncontrolled hypertension than do people of other racial/ethnic groups. Little is known about the prevalence and predictors of antihypertensive medication adherence, a major determinant of hypertension control and cardiovascular disease, and differences between age groups in this fast-growing population. METHODS: The cross-sectional study included 1,043 community-dwelling Hispanic adults with hypertension living in 3 northern Manhattan neighborhoods from 2011 through 2012...
July 13, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28630235/ultrasound-markers-of-carotid-atherosclerosis-and-cognition-the-northern-manhattan-study
#9
Hannah Gardener, Michelle R Caunca, Chuanhui Dong, Ying Kuen Cheung, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek, Clinton B Wright
BACKGROUND AND PURPOSE: Ultrasound markers of carotid atherosclerosis may be related to cognitive status. We hypothesized that individuals with greater carotid intima-media thickness (cIMT) and carotid plaque burden would exhibit worse cognition. METHODS: One thousand one hundred sixty-six stroke-free participants from the NOMAS (Northern Manhattan Study) underwent carotid ultrasound and neuropsychological examination. Among them, 826 underwent a second neuropsychological examination an average of 5 years later...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28555103/blood-pressure-control-in-aging-predicts-cerebral-atrophy-related-to-small-vessel-white-matter-lesions
#10
Kyle C Kern, Clinton B Wright, Kaitlin L Bergfield, Megan C Fitzhugh, Kewei Chen, James R Moeller, Nooshin Nabizadeh, Mitchell S V Elkind, Ralph L Sacco, Yaakov Stern, Charles S DeCarli, Gene E Alexander
Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28455324/long-term-exposure-to-ambient-air-pollution-and-subclinical-cerebrovascular-disease-in-nomas-the-northern-manhattan-study
#11
Erin R Kulick, Gregory A Wellenius, Joel D Kaufman, Janet T DeRosa, Patrick L Kinney, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S Elkind
BACKGROUND AND PURPOSE: Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. METHODS: Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28453789/association-between-serum-tumor-necrosis-factor-receptor-1-and-trajectories-of-functional-status-the-northern-manhattan-study
#12
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon P Moon, Clinton B Wright, Joshua Z Willey, Ralph L Sacco, Mitchell S V Elkind
We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged ≥40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863)...
July 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28357682/quality-of-life-independently-predicts-long-term-mortality-but-not-vascular-events-the-northern-manhattan-study
#13
John W Liang, Ying Kuen Cheung, Joshua Z Willey, Yeseon P Moon, Ralph L Sacco, Mitchell S V Elkind, Mandip S Dhamoon
PURPOSE: Cardiovascular disease is a major contributor to morbidity and mortality, and prevention relies on accurate identification of those at risk. Studies of the association between quality of life (QOL) and mortality and vascular events incompletely accounted for depression, cognitive status, social support, and functional status, all of which have an impact on vascular outcomes. We hypothesized that baseline QOL is independently associated with long-term mortality in a large, multi-ethnic urban cohort...
August 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28341719/brain-perivascular-spaces-as-biomarkers-of-vascular-risk-results-from-the-northern-manhattan-study
#14
J Gutierrez, M S V Elkind, C Dong, M Di Tullio, T Rundek, R L Sacco, C B Wright
BACKGROUND AND PURPOSE: Dilated perivascular spaces in the brain are associated with greater arterial pulsatility. We hypothesized that perivascular spaces identify individuals at higher risk for systemic and cerebral vascular events. MATERIALS AND METHODS: Stroke-free participants in the population-based Northern Manhattan Study had brain MR imaging performed and were followed for myocardial infarction, any stroke, and death. Imaging analyses distinguished perivascular spaces from lesions presumably ischemic...
May 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28323321/observed-hearing-loss-and-incident-dementia-in-a-multiethnic-cohort
#15
Justin S Golub, José A Luchsinger, Jennifer J Manly, Yaakov Stern, Richard Mayeux, Nicole Schupf
OBJECTIVES: To determine whether observed hearing loss (OHL) is associated with incident dementia in a multiethnic population. DESIGN: Prospective epidemiological cohort study. SETTING: Community in northern Manhattan. PARTICIPANTS: Participants in the Washington Heights-Inwood Columbia Aging Project, a longitudinal study on aging and dementia in an ethnically diverse community (n = 1,881). MEASUREMENTS: OHL was defined when the examiner observed it or according to self-reported hearing aid use...
August 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28181636/c-reactive-protein-is-associated-with-disability-independently-of-vascular-events-the-northern-manhattan-study
#16
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon P Moon, Clinton B Wright, Joshua Z Willey, Ralph Sacco, Mitchell Sv Elkind
Background: High-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. Design: Prospective, population-based. Setting: Northern Manhattan Study...
January 15, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28160312/cox-proportional-hazards-models-with-left-truncation-and-time-varying-coefficient-application-of-age-at-event-as-outcome-in-cohort-studies
#17
Minjin Kim, Myunghee Cho Paik, Jiyeong Jang, Ying K Cheung, Joshua Willey, Mitchell S V Elkind, Ralph L Sacco
When analyzing time-to-event cohort data, two different ways of choosing a time scale have been discussed in the literature: time-on-study or age at onset of disease. One advantage of choosing the latter is interpretability of the hazard ratio as a function of age. To handle the analysis of age at onset in a principled manner, we present an analysis of the Cox Proportional Hazards model with time-varying coefficient for left-truncated and right-censored data. In the analysis of Northern Manhattan Study (NOMAS) with age at onset of stroke as outcome, we demonstrate that well-established risk factors may be important only around a certain age span and less established risk factors can have a strong effect in a certain age span...
May 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28123058/procalcitonin-and-midregional-proatrial-natriuretic-peptide-as-biomarkers-of-subclinical-cerebrovascular-damage-the-northern-manhattan-study
#18
Mira Katan, Yeseon Moon, Arnold von Eckardstein, Kathartina Spanaus, Janet DeRosa, Jose Gutierrez, Charles DeCarli, Clinton Wright, Ralph Sacco, Mitchell Elkind
BACKGROUND AND PURPOSE: Chronic infections and cardiac dysfunction are risk factors for stroke. We hypothesized that blood biomarkers of infection (procalcitonin) and cardiac dysfunction (midregional proatrial natriuretic peptide [MR-proANP]), previously associated with small vessel stroke and cardioembolic stroke are also associated with subclinical cerebrovascular damage, including silent brain infarcts and white matter hyperintensity volume. METHODS: The NOMAS (Northern Manhattan Study) was designed to assess risk factors for incident vascular disease in a multiethnic cohort...
March 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28115816/sickle-cell-trait-and-renal-function-in-hispanics-in-the-united-states-the-northern-manhattan-study
#19
Nicole D Dueker, David Della-Morte, Tatjana Rundek, Ralph L Sacco, Susan H Blanton
Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United States; the disorder results in the production of abnormal hemoglobin. It is caused by homozygosity for a genetic mutation in HBB; rs334. While the presence of a single mutation (sickle cell trait, SCT) has long been considered a benign trait, recent research suggests that SCT is associated with renal dysfunction, including a decrease in estimated glomerular filtration rate (eGFR) and increased risk of chronic kidney disease (CKD) in African Americans...
January 19, 2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28049199/systemic-atherosclerosis-relate-to-brain-arterial-diameters-the-northern-manhattan-study
#20
Jose Gutierrez, Tatjana Rundek, Ken Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind, Marco R Di Tullio
BACKGROUND: Phenotypic expressions of arterial disease vary throughout the body and it is not clear to what extent systemic atherosclerosis influences brain arterial remodeling. We aim to test the hypothesis that systemic atherosclerosis is associated with brain arterial diameters. METHODS: Stroke-free participants in the Northern Manhattan Study MRI subcohort in whom carotid ultrasound, transthoracic echocardiogram, and brain MRA (n = 482) were performed were included in this analysis...
2017: Cerebrovascular Diseases
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