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Northern Manhattan Study

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https://www.readbyqxmd.com/read/29779259/periodontal-status-among-elderly-inhabitants-of-northern-manhattan-the-whicap-ancillary-study-of-oral-health
#1
Jaffer A Shariff, Sandra Burkett, Caitlin Wei-Ming Watson, Bin Cheng, James M Noble, Panos N Papapanou
AIM: We conducted a cross-sectional study of the prevalence, extent and severity of periodontitis in a tri-ethnic cohort of ≥65 year-old participants of the Washington-Heights Inwood Community Aging Project (WHICAP). METHODS: 1,130 individuals (57% of eligible invitees) participated in a full-mouth periodontal examination that included assessments of bleeding on probing, pocket depth and clinical attachment loss (CAL) at six sites/tooth. RESULTS: Participants had a mean age of 75...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29775990/cox-model-with-interval-censored-covariate-in-cohort-studies
#2
Soohyun Ahn, Johan Lim, Myunghee Cho Paik, Ralph L Sacco, Mitchell S Elkind
In cohort studies the outcome is often time to a particular event, and subjects are followed at regular intervals. Periodic visits may also monitor a secondary irreversible event influencing the event of primary interest, and a significant proportion of subjects develop the secondary event over the period of follow-up. The status of the secondary event serves as a time-varying covariate, but is recorded only at the times of the scheduled visits, generating incomplete time-varying covariates. While information on a typical time-varying covariate is missing for entire follow-up period except the visiting times, the status of the secondary event are unavailable only between visits where the status has changed, thus interval-censored...
May 18, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29743209/greater-depressive-symptoms-cognition-and-markers-of-brain-aging-northern-manhattan-study
#3
Adina Zeki Al Hazzouri, Michelle R Caunca, Juan Carlos Nobrega, Tali Elfassy, Ying Kuen Cheung, Noam Alperin, Chuanhui Dong, Mitchell S V Elkind, Ralph L Sacco, Charles DeCarli, Clinton B Wright
OBJECTIVE: We examined whether greater depressive symptoms were associated with domain-specific cognitive performance, change in cognition, and MRI markers of brain atrophy and subclinical cerebrovascular disease in a diverse sample of older adults from the Northern Manhattan Study. METHODS: Data were analyzed from the Northern Manhattan Study, a prospective cohort study of mostly Caribbean Hispanic, stroke-free, older adults. A total of 1,111 participants had baseline measures of depressive symptoms, measured as the Center of Epidemiological Studies-Depression Scale, MRI markers, and cognitive function...
May 9, 2018: Neurology
https://www.readbyqxmd.com/read/29713306/association-between-carotid-artery-function-and-structure-in-the-northern-manhattan-study
#4
David Della-Morte, Hannah Gardener, Chuanhui Dong, Matthew Markert, Digna Cabral, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek
Background and purpose: Carotid plaque (CP), carotid intima media thickness (cIMT), and stiffness (STIFF) are pre-clinical markers of atherosclerosis and predictors of cerebrovascular disease (CVD). We sought to investigate whether STIFF is a significant determinant of cIMT and CP, which may provide an insight into the mechanism by which STIFF adds to the risk of CVD. Methods: We analyzed 876 stroke-free subjects from the Northern Manhattan Study with available ultrasound measures...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29558467/cerebral-white-matter-disease-and-functional-decline-in-older-adults-from-the-northern-manhattan-study-a-longitudinal-cohort-study
#5
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon Moon, Janet DeRosa, Ralph Sacco, Mitchell S V Elkind, Clinton B Wright
BACKGROUND: Cerebral white matter hyperintensities (WMHs) on MRI are common and associated with vascular and functional outcomes. However, the relationship between WMHs and longitudinal trajectories of functional status is not well characterized. We hypothesized that whole brain WMHs are associated with functional decline independently of intervening clinical vascular events and other vascular risk factors. METHODS AND FINDINGS: In the Northern Manhattan Study (NOMAS), a population-based racially/ethnically diverse prospective cohort study, 1,290 stroke-free individuals underwent brain MRI and were followed afterwards for a mean 7...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29556112/modeling-accessibility-of-screening-and-treatment-facilities-for-older-adults-using-transportation-networks
#6
Qiuyi Zhang, Mary E Northridge, Zhu Jin, Sara S Metcalf
Increased lifespans and population growth have resulted in an older U.S. society that must reckon with the complex oral health needs that arise as adults age. Understanding accessibility to screening and treatment facilities for older adults is necessary in order to provide them with preventive and restorative services. This study uses an agent-based model to examine the accessibility of screening and treatment facilities via transportation networks for older adults living in the neighborhoods of northern Manhattan, New York City...
April 2018: Applied Geography
https://www.readbyqxmd.com/read/29540609/residential-proximity-to-major-roadways-and-risk-of-incident-ischemic-stroke-in-nomas-the-northern-manhattan-study
#7
Erin R Kulick, Gregory A Wellenius, Amelia K Boehme, Ralph L Sacco, Mitchell S Elkind
BACKGROUND AND PURPOSE: The evidence supporting the deleterious cardiovascular health effects of living near a major roadway is growing, although this association is not universal. In primary analyses, we hypothesized that residential proximity to a major roadway would be associated with incident ischemic stroke and that cardiovascular risk factors would modify that association. METHODS: NOMAS (The Northern Manhattan Study) is an ongoing, population-based cohort study designed to measure cardiovascular risk factors, stroke incidence, and other outcomes in a multiethnic urban population...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29376850/a-link-between-subjective-perceptions-of-memory-and-physical-function-implications-for-subjective-cognitive-decline
#8
Stephanie Cosentino, Davangere Devanand, Barry Gurland
Subjective impairment in memory is a frequently defining feature of subjective cognitive decline (SCD), a state hypothesized to precede objectively apparent cognitive symptoms of Alzheimer's disease (AD) and to hold promise as a non-invasive, inexpensive, preclinical indicator of AD. However, a full model of the factors that contribute to subjective memory (SM), and therefore to SCD, has yet to be articulated. While SM impairment is widely known to be associated with negative affect, the extent to which SM functioning may also reflect other factors, particularly subjective beliefs or perceptions about one's health, is not known...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29324717/residual-inequity-assessing-the-unintended-consequences-of-new-york-city-s-clean-heat-transition
#9
Daniel Carrión, W Victoria Lee, Diana Hernández
Energy policies and public health are intimately intertwined. In New York City, a series of policies, known as the Clean Heat Program (CHP), were designed to reduce air pollution by banning residual diesel fuel oils, #6 in 2015 and #4 by 2030. This measure is expected to yield environmental and public health benefits over time. While there is near-universal compliance with the #6 ban, a substantial number of buildings still use #4. In this paper, geographic analysis and qualitative interviews with stakeholders were used to interrogate the CHP's policy implementation in Northern Manhattan and the Bronx...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29314188/-seniors-only-want-respect-designing-an-oral-health-program-for-older-adults
#10
Ivette Estrada, Carol Kunzel, Eric W Schrimshaw, Ariel P Greenblatt, Sara S Metcalf, Mary E Northridge
AIM: Persistent socioeconomic disparities in the oral disease burden contribute to pain and suffering among vulnerable and underserved populations who face systemic barriers to access oral health care, including older adults living in disadvantaged urban neighborhoods. The aim of this study is to gain the views of racial/ethnic minority older adults regarding what they believe would support them and their peers in visiting the dentist regularly. METHODS AND RESULTS: Focus groups were conducted and digitally audio-recorded from 2013 to 2015 with 194 racial/ethnic minority women and men aged 50 years and older living in northern Manhattan who participated in one of 24 focus group sessions about improving oral health for older adults...
January 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29288195/sequencing-of-linkage-region-on-chromosome-12p11-identifies-pkp2-as-a-candidate-gene-for-left-ventricular-mass-in-dominican-families
#11
Nicole D Dueker, Shengru Guo, Ashley Beecham, Liyong Wang, Susan H Blanton, Marco R Di Tullio, Tatjana Rundek, Ralph L Sacco
Increased left ventricular mass (LVM) is an intermediate phenotype for cardiovascular disease (CVD) and a predictor of stroke. Using families from the Dominican Republic, we have previously shown LVM to be heritable and found evidence for linkage to chromosome 12p11. Our current study aimed to further characterize the QTL by sequencing the 1 LOD unit down region in 10 families from the Dominican Republic with evidence for linkage to LVM. Within this region, we tested 5477 common variants [CVs; minor allele frequency (MAF) ≥5%] using the Quantitative Transmission-Disequilibrium Test (QTDT)...
February 2, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29284725/carotid-intima-media-thickness-is-associated-with-white-matter-hyperintensities-the-northern-manhattan-study
#12
David Della-Morte, Chuanhui Dong, Matthew S Markert, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Tatjana Rundek
BACKGROUND AND PURPOSE: Brain white matter hyperintensities (WMH) have been associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a manifestation of small vessel disease, although the total microvascular contribution to multifactorial WMH pathophysiology remains unknown. We hypothesized a possible relationship between carotid intima-media thickness (cIMT), an ultrasound imaging marker of subclinical vascular disease, and brain WMH in a multiethnic, elderly stroke-free community-based cohort...
February 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29284462/estimating-peer-density-effects-on-oral-health-for-community-based-older-adults
#13
Bibhas Chakraborty, Michael J Widener, Sedigheh Mirzaei Salehabadi, Mary E Northridge, Susan S Kum, Zhu Jin, Carol Kunzel, Harvey D Palmer, Sara S Metcalf
BACKGROUND: As part of a long-standing line of research regarding how peer density affects health, researchers have sought to understand the multifaceted ways that the density of contemporaries living and interacting in proximity to one another influence social networks and knowledge diffusion, and subsequently health and well-being. This study examined peer density effects on oral health for racial/ethnic minority older adults living in northern Manhattan and the Bronx, New York, NY...
December 29, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29221780/short-sleep-is-associated-with-more-depressive-symptoms-in-a-multi-ethnic-cohort-of-older-adults
#14
Suzanne Lippman, Hannah Gardener, Tatjana Rundek, Azizi Seixas, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Alberto R Ramos
OBJECTIVES: To evaluate cross-sectional and prospective associations between short and long sleep duration and depressive symptoms in older adults (aged >65 years). METHODS: The data from a subsample of the racially/ethnically diverse Northern Manhattan Study were analyzed. Depressive symptoms were assessed twice with the Center for Epidemiologic Studies Depression Scale (CES-D), approximately 5 years apart. The presence of depressive symptoms was defined as a CES-D score ≥16 or use of antidepressants...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29166955/brain-arterial-diameters-and-cognitive-performance-the-northern-manhattan-study
#15
Jose Gutierrez, Erin Kulick, Yeseon Park Moon, Chuanhui Dong, Ken Cheung, Bagci Ahmet, Yaakov Stern, Noam Alperin, Tatjana Rundek, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind
OBJECTIVES: To test the hypothesis that brain arterial diameters are associated with cognitive performance, particularly in arteries supplying domain-specific territories. METHODS: Stroke-free participants in the Northern Manhattan Study were invited to have a brain MRI from 2003-2008. The luminal diameters of 13 intracranial arterial segments were obtained using time-of-flight magnetic resonance angiogram (MRA), and then averaged and normalized into a global score and region-specific arterial diameters...
April 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29155435/periventricular-white-matter-hyperintensities-and-functional-decline
#16
Mandip S Dhamoon, Ying-Kuen Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
BACKGROUND/OBJECTIVES: We previously showed that global brain white matter hyperintensity volume (WMHV) was associated with accelerated long-term functional decline. The objective of the current study was to determine whether WMHV in particular brain regions is more predictive of functional decline. DESIGN: Prospective population-based study. SETTING: Northern Manhattan magnetic resonance imaging (MRI) study. PARTICIPANTS: Individuals free of stroke at baseline (N = 1,195; mean age 71 ± 9; n = 460 (39%) male)...
January 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29103864/apolipoprotein-e-gene-polymorphism-and-subclinical-carotid-atherosclerosis-the-northern-manhattan-study
#17
Brett Doliner, Chuanhui Dong, Susan H Blanton, Hannah Gardener, Mitchell S V Elkind, Ralph L Sacco, Ryan T Demmer, Moise Desvarieux, Tatjana Rundek
BACKGROUND: Apolipoprotein E (APOE) polymorphism has previously been associated with carotid intima-media thickness (cIMT) in predominantly Caucasian populations. We sought to test the strength of the relationship between APOE-ε4 carrier status and subclinical atherosclerosis in a tri-ethnic population with a large Hispanic representation. METHODS: We assessed the association between APOE polymorphism and cIMT and plaque burden among 1243 stroke-free individuals (mean age 69 years, 65% Hispanic, 18% black, 17% white) using a sequence of multivariable regression models...
March 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29018136/dietary-sodium-to-potassium-ratio-and-risk-of-stroke-in-a-multiethnic-urban-population-the-northern-manhattan-study
#18
MULTICENTER STUDY
Joshua Willey, Hannah Gardener, Sandino Cespedes, Ying K Cheung, Ralph L Sacco, Mitchell S V Elkind
BACKGROUND AND PURPOSE: There is growing evidence that increased dietary sodium (Na) intake increases the risk of vascular diseases, including stroke, at least in part via an increase in blood pressure. Higher dietary potassium (K), seen with increased intake of fruits and vegetables, is associated with lower blood pressure. The goal of this study was to determine the association of a dietary Na:K with risk of stroke in a multiethnic urban population. METHODS: Stroke-free participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were followed-up for incident stroke...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28984588/secular-trends-in-the-incidence-of-dementia-in-a-multi-ethnic-community
#19
James M Noble, Nicole Schupf, Jennifer J Manly, Howard Andrews, Ming-Xin Tang, Richard Mayeux
BACKGROUND: Determination of secular trends in cognitive aging is important for prioritization of resources, services, and research in aging populations. Prior studies have identified declining dementia incidence associated with changes in cardiovascular risk factors and increased educational attainment. However, few studies have examined these factors in multi-ethnic cohorts. OBJECTIVE: To identify secular trends in the incidence rate of dementia in an elderly population...
October 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28975155/genome-wide-scan-in-hispanics-highlights-candidate-loci-for-brain-white-matter-hyperintensities
#20
Ashley Beecham, Chuanhui Dong, Clinton B Wright, Nicole Dueker, Adam M Brickman, Liyong Wang, Charles DeCarli, Susan H Blanton, Tatjana Rundek, Richard Mayeux, Ralph L Sacco
OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population. METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights-Inwood Columbia Aging Project...
October 2017: Neurology. Genetics
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