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Northern Manhattan Study

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https://www.readbyqxmd.com/read/29324717/residual-inequity-assessing-the-unintended-consequences-of-new-york-city-s-clean-heat-transition
#1
Daniel Carrión, W Victoria Lee, Diana Hernández
Energy policies and public health are intimately intertwined. In New York City, a series of policies, known as the Clean Heat Program (CHP), were designed to reduce air pollution by banning residual diesel fuel oils, #6 in 2015 and #4 by 2030. This measure is expected to yield environmental and public health benefits over time. While there is near-universal compliance with the #6 ban, a substantial number of buildings still use #4. In this paper, geographic analysis and qualitative interviews with stakeholders were used to interrogate the CHP's policy implementation in Northern Manhattan and the Bronx...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29314188/-seniors-only-want-respect-designing-an-oral-health-program-for-older-adults
#2
Ivette Estrada, Carol Kunzel, Eric W Schrimshaw, Ariel P Greenblatt, Sara S Metcalf, Mary E Northridge
AIM: Persistent socioeconomic disparities in the oral disease burden contribute to pain and suffering among vulnerable and underserved populations who face systemic barriers to access oral health care, including older adults living in disadvantaged urban neighborhoods. The aim of this study is to gain the views of racial/ethnic minority older adults regarding what they believe would support them and their peers in visiting the dentist regularly. METHODS AND RESULTS: Focus groups were conducted and digitally audio-recorded from 2013 to 2015 with 194 racial/ethnic minority women and men aged 50 years and older living in northern Manhattan who participated in one of 24 focus group sessions about improving oral health for older adults...
January 4, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29288195/sequencing-of-linkage-region-on-chromosome-12p11-identifies-pkp2-as-a-candidate-gene-for-left-ventricular-mass-in-dominican-families
#3
Nicole D Dueker, Shengru Guo, Ashley Beecham, Liyong Wang, Susan H Blanton, Marco R Di Tullio, Tatjana Rundek, Ralph L Sacco
Increased left ventricular mass (LVM) is an intermediate phenotype for cardiovascular disease (CVD) and a predictor of stroke. Using families from the Dominican Republic, we have previously shown LVM to be heritable and found evidence for linkage to chromosome 12p11. Our current study aimed to further characterize the QTL by sequencing the 1 LOD unit down region in ten families from the Dominican Republic with evidence for linkage to LVM. Within this region, we tested 5,477 common variants (CVs; minor allele frequency [MAF] ≥5%) using the QTDT test...
December 29, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29284725/carotid-intima-media-thickness-is-associated-with-white-matter-hyperintensities-the-northern-manhattan-study
#4
David Della-Morte, Chuanhui Dong, Matthew S Markert, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Tatjana Rundek
BACKGROUND AND PURPOSE: Brain white matter hyperintensities (WMH) have been associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a manifestation of small vessel disease, although the total microvascular contribution to multifactorial WMH pathophysiology remains unknown. We hypothesized a possible relationship between carotid intima-media thickness (cIMT), an ultrasound imaging marker of subclinical vascular disease, and brain WMH in a multiethnic, elderly stroke-free community-based cohort...
December 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29284462/estimating-peer-density-effects-on-oral-health-for-community-based-older-adults
#5
Bibhas Chakraborty, Michael J Widener, Sedigheh Mirzaei Salehabadi, Mary E Northridge, Susan S Kum, Zhu Jin, Carol Kunzel, Harvey D Palmer, Sara S Metcalf
BACKGROUND: As part of a long-standing line of research regarding how peer density affects health, researchers have sought to understand the multifaceted ways that the density of contemporaries living and interacting in proximity to one another influence social networks and knowledge diffusion, and subsequently health and well-being. This study examined peer density effects on oral health for racial/ethnic minority older adults living in northern Manhattan and the Bronx, New York, NY...
December 29, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29221780/short-sleep-is-associated-with-more-depressive-symptoms-in-a-multi-ethnic-cohort-of-older-adults
#6
Suzanne Lippman, Hannah Gardener, Tatjana Rundek, Azizi Seixas, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Alberto R Ramos
OBJECTIVES: To evaluate cross-sectional and prospective associations between short and long sleep duration and depressive symptoms in older adults (aged >65 years). METHODS: The data from a subsample of the racially/ethnically diverse Northern Manhattan Study were analyzed. Depressive symptoms were assessed twice with the Center for Epidemiologic Studies Depression Scale (CES-D), approximately 5 years apart. The presence of depressive symptoms was defined as a CES-D score ≥16 or use of antidepressants...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29166955/brain-arterial-diameters-and-cognitive-performance-the-northern-manhattan-study
#7
Jose Gutierrez, Erin Kulick, Yeseon Park Moon, Chuanhui Dong, Ken Cheung, Bagci Ahmet, Yaakov Stern, Noam Alperin, Tatjana Rundek, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind
OBJECTIVES: To test the hypothesis that brain arterial diameters are associated with cognitive performance, particularly in arteries supplying domain-specific territories. METHODS: Stroke-free participants in the Northern Manhattan Study were invited to have a brain MRI from 2003-2008. The luminal diameters of 13 intracranial arterial segments were obtained using time-of-flight magnetic resonance angiogram (MRA), and then averaged and normalized into a global score and region-specific arterial diameters...
November 23, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29155435/periventricular-white-matter-hyperintensities-and-functional-decline
#8
Mandip S Dhamoon, Ying-Kuen Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
BACKGROUND/OBJECTIVES: We previously showed that global brain white matter hyperintensity volume (WMHV) was associated with accelerated long-term functional decline. The objective of the current study was to determine whether WMHV in particular brain regions is more predictive of functional decline. DESIGN: Prospective population-based study. SETTING: Northern Manhattan magnetic resonance imaging (MRI) study. PARTICIPANTS: Individuals free of stroke at baseline (N = 1,195; mean age 71 ± 9; n = 460 (39%) male)...
November 20, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29103864/apolipoprotein-e-gene-polymorphism-and-subclinical-carotid-atherosclerosis-the-northern-manhattan-study
#9
Brett Doliner, Chuanhui Dong, Susan H Blanton, Hannah Gardener, Mitchell S V Elkind, Ralph L Sacco, Ryan T Demmer, Moise Desvarieux, Tatjana Rundek
BACKGROUND: Apolipoprotein E (APOE) polymorphism has previously been associated with carotid intima-media thickness (cIMT) in predominantly Caucasian populations. We sought to test the strength of the relationship between APOE-ε4 carrier status and subclinical atherosclerosis in a tri-ethnic population with a large Hispanic representation. METHODS: We assessed the association between APOE polymorphism and cIMT and plaque burden among 1243 stroke-free individuals (mean age 69 years, 65% Hispanic, 18% black, 17% white) using a sequence of multivariable regression models...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29018136/dietary-sodium-to-potassium-ratio-and-risk-of-stroke-in-a-multiethnic-urban-population-the-northern-manhattan-study
#10
MULTICENTER STUDY
Joshua Willey, Hannah Gardener, Sandino Cespedes, Ying K Cheung, Ralph L Sacco, Mitchell S V Elkind
BACKGROUND AND PURPOSE: There is growing evidence that increased dietary sodium (Na) intake increases the risk of vascular diseases, including stroke, at least in part via an increase in blood pressure. Higher dietary potassium (K), seen with increased intake of fruits and vegetables, is associated with lower blood pressure. The goal of this study was to determine the association of a dietary Na:K with risk of stroke in a multiethnic urban population. METHODS: Stroke-free participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were followed-up for incident stroke...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28984588/secular-trends-in-the-incidence-of-dementia-in-a-multi-ethnic-community
#11
James M Noble, Nicole Schupf, Jennifer J Manly, Howard Andrews, Ming-Xin Tang, Richard Mayeux
BACKGROUND: Determination of secular trends in cognitive aging is important for prioritization of resources, services, and research in aging populations. Prior studies have identified declining dementia incidence associated with changes in cardiovascular risk factors and increased educational attainment. However, few studies have examined these factors in multi-ethnic cohorts. OBJECTIVE: To identify secular trends in the incidence rate of dementia in an elderly population...
October 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28975155/genome-wide-scan-in-hispanics-highlights-candidate-loci-for-brain-white-matter-hyperintensities
#12
Ashley Beecham, Chuanhui Dong, Clinton B Wright, Nicole Dueker, Adam M Brickman, Liyong Wang, Charles DeCarli, Susan H Blanton, Tatjana Rundek, Richard Mayeux, Ralph L Sacco
OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population. METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights-Inwood Columbia Aging Project...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28970793/differential-effect-of-left-vs-right-white-matter-hyperintensity-burden-on-functional-decline-the-northern-manhattan-study
#13
Mandip S Dhamoon, Ying-Kuen Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
Asymmetry of brain dysfunction may disrupt brain network efficiency. We hypothesized that greater left-right white matter hyperintensity volume (WMHV) asymmetry was associated with functional trajectories. Methods: In the Northern Manhattan Study, participants underwent brain MRI with axial T1, T2, and fluid attenuated inversion recovery sequences, with baseline interview and examination. Volumetric WMHV distribution across 14 brain regions was determined separately by combining bimodal image intensity distribution and atlas based methods...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28944291/acceptability-of-chairside-screening-for-racial-ethnic-minority-older-adults-a-qualitative-study
#14
A P Greenblatt, I Estrada, E W Schrimshaw, S S Metcalf, C Kunzel, M E Northridge
An aging and more racially and ethnically diverse population, coupled with changes in the health care policy environment, is demanding that the dental profession both redirect and expand its focus. Challenges include providing comprehensive care for patients with complicated medical needs while improving access to care for underserved groups. The purpose of this study is to examine the acceptability of screening for hypertension and diabetes in the dental setting for African American, Puerto Rican, and Dominican older adults who attend senior centers in northern Manhattan, New York City...
October 2017: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/28810247/physical-inactivity-predicts-slow-gait-speed-in-an-elderly-multi-ethnic-cohort-study-the-northern-manhattan-study
#15
Joshua Z Willey, Yeseon P Moon, Erin R Kulick, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind
INTRODUCTION: Gait speed is associated with multiple adverse outcomes of aging. We hypothesized that physical inactivity would be prospectively inversely associated with gait speed independently of white matter hyperintensity volume and silent brain infarcts on MRI. METHODS: Participants in the Northern Manhattan Study MRI sub-study had physical activity assessed when they were enrolled into the study. A mean of 5 years after the MRI, participants had gait speed measured via a timed 5-meter walk test...
2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28704175/age-related-differences-in-antihypertensive-medication-adherence-in-hispanics-a-cross-sectional-community-based-survey-in-new-york-city-2011-2012
#16
Priti Bandi, Emily Goldmann, Nina S Parikh, Parisa Farsi, Bernadette Boden-Albala
INTRODUCTION: US Hispanics, particularly younger adults in this population, have a higher prevalence of uncontrolled hypertension than do people of other racial/ethnic groups. Little is known about the prevalence and predictors of antihypertensive medication adherence, a major determinant of hypertension control and cardiovascular disease, and differences between age groups in this fast-growing population. METHODS: The cross-sectional study included 1,043 community-dwelling Hispanic adults with hypertension living in 3 northern Manhattan neighborhoods from 2011 through 2012...
July 13, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28630235/ultrasound-markers-of-carotid-atherosclerosis-and-cognition-the-northern-manhattan-study
#17
Hannah Gardener, Michelle R Caunca, Chuanhui Dong, Ying Kuen Cheung, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek, Clinton B Wright
BACKGROUND AND PURPOSE: Ultrasound markers of carotid atherosclerosis may be related to cognitive status. We hypothesized that individuals with greater carotid intima-media thickness (cIMT) and carotid plaque burden would exhibit worse cognition. METHODS: One thousand one hundred sixty-six stroke-free participants from the NOMAS (Northern Manhattan Study) underwent carotid ultrasound and neuropsychological examination. Among them, 826 underwent a second neuropsychological examination an average of 5 years later...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28555103/blood-pressure-control-in-aging-predicts-cerebral-atrophy-related-to-small-vessel-white-matter-lesions
#18
Kyle C Kern, Clinton B Wright, Kaitlin L Bergfield, Megan C Fitzhugh, Kewei Chen, James R Moeller, Nooshin Nabizadeh, Mitchell S V Elkind, Ralph L Sacco, Yaakov Stern, Charles S DeCarli, Gene E Alexander
Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28455324/long-term-exposure-to-ambient-air-pollution-and-subclinical-cerebrovascular-disease-in-nomas-the-northern-manhattan-study
#19
Erin R Kulick, Gregory A Wellenius, Joel D Kaufman, Janet T DeRosa, Patrick L Kinney, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S Elkind
BACKGROUND AND PURPOSE: Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. METHODS: Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28453789/association-between-serum-tumor-necrosis-factor-receptor-1-and-trajectories-of-functional-status-the-northern-manhattan-study
#20
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon P Moon, Clinton B Wright, Joshua Z Willey, Ralph L Sacco, Mitchell S V Elkind
We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged ≥40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863)...
July 1, 2017: American Journal of Epidemiology
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