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Northern Manhattan Study

Jose Gutierrez, Tatjana Rundek, Ken Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind, Marco R Di Tullio
BACKGROUND: Phenotypic expressions of arterial disease vary throughout the body and it is not clear to what extent systemic atherosclerosis influences brain arterial remodeling. We aim to test the hypothesis that systemic atherosclerosis is associated with brain arterial diameters. METHODS: Stroke-free participants in the Northern Manhattan Study MRI subcohort in whom carotid ultrasound, transthoracic echocardiogram, and brain MRA (n = 482) were performed were included in this analysis...
January 4, 2017: Cerebrovascular Diseases
Christiane Reitz, Vanessa A Guzman, Atul Narkhede, Charles DeCarli, Adam M Brickman, José A Luchsinger
OBJECTIVES: Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The objective of this study was to examine the relation of dysglycemia clinical categories (normal glucose tolerance (NGT), pre-diabetes, undiagnosed diabetes, known diabetes) with brain structure in older adults. We also assessed the relation between dysglycemia and cognitive performance...
December 5, 2016: Journal of the American Geriatrics Society
William Cheung
No abstract text is available yet for this article.
November 28, 2016: Journal of General Internal Medicine
José A Luchsinger, Louis Burgio, Mary Mittelman, Ilana Dunner, Jed A Levine, Jian Kong, Stephanie Silver, Mildred Ramirez, Jeanne A Teresi
INTRODUCTION: The prevalence of dementia is increasing without a known cure, resulting in an increasing number of informal caregivers. Caring for a person with dementia results in increased stress and depressive symptoms. There are several behavioural interventions designed to alleviate stress and depressive symptoms in caregivers of persons with dementia with evidence of efficacy. Two of the best-known interventions are the New York University Caregiver Intervention (NYUCI) and the Resources for Enhancing Alzheimer's Caregivers Health (REACH)...
November 25, 2016: BMJ Open
Ying Kuen Cheung, Yeseon P Moon, Erin R Kulick, Ralph L Sacco, Mitchell S V Elkind, Joshua Z Willey
BACKGROUND: Previous studies of exercise have focused on measuring physical activity in totality using summary statistics such as metabolic equivalent score for total intensity or total energy count. OBJECTIVE: We aimed to examine the multidimensionality of leisure-time physical activity (LTPA) and to identify the specific LTPA components that were associated with cardiovascular mortality in the elderly. DESIGN AND PARTICIPANTS: The Northern Manhattan Study (NOMAS) is a multiethnic prospective cohort of elderly stroke-free individuals consisting of a total of 3298 participants recruited between 1993 and 2001, with a median follow-up of 17 years...
October 17, 2016: Journal of General Internal Medicine
Mandip S Dhamoon, Ying-Kuen Cheung, Yeseon P Moon, Clinton B Wright, Joshua Z Willey, Ralph Sacco, Mitchell Sv Elkind
BACKGROUND: high-sensitivity C-reactive protein (CRP) has been associated with cardiovascular events and mortality, but the association of CRP with functional status is not well defined. We hypothesised that serum levels of high-sensitivity CRP are associated with long-term trajectories of functional status independently of vascular risk factors and stroke and myocardial infarction (MI) occurring during follow-up. DESIGN: prospective, population-based. SETTING: northern Manhattan Study...
October 15, 2016: Age and Ageing
Stephanie Lovinsky-Desir, Kyung Hwa Jung, Andrew G Rundle, Lori A Hoepner, Joshua B Bautista, Frederica P Perera, Steven N Chillrud, Matthew S Perzanowski, Rachel L Miller
OBJECTIVE: Regular physical activity can improve cardiopulmonary health; however, increased respiratory rates and tidal volumes during activity may increase the effective internal dose of air pollution exposure. Our objective was to investigate the impact of black carbon (BC) measured by personal sampler on the relationship between physical activity and fractional exhaled nitric oxide (FeNO), a marker of airway inflammation. We hypothesized that higher personal BC would attenuate the protective effect of physical activity on airway inflammation...
November 2016: Environmental Research
Michelle R Caunca, Victor Del Brutto, Hannah Gardener, Nirav Shah, Nelly Dequatre-Ponchelle, Ying Kuen Cheung, Mitchell S V Elkind, Truman R Brown, Charlotte Cordonnier, Ralph L Sacco, Clinton B Wright
BACKGROUND: Cerebral microbleeds (CMBs) represent intracerebral hemorrhages due to amyloid angiopathy or exposure to modifiable risk factors. Few community-based stroke-free studies including blacks and Hispanics have been done. METHODS AND RESULTS: The Northern Manhattan Study (NOMAS) is a stroke-free, racially and ethnically diverse cohort study. Brain MRI was performed in 1290 participants, 925 of whom had available T2* gradient-recall echo data. We used multivariable logistic regression to examine the association of sociodemographics, vascular risk factors, apolipoprotein E (APOE) genotype, and brain MRI markers with CMB presence and location...
September 2016: Journal of the American Heart Association
Alberto R Ramos, Hannah Gardener, Tatjana Rundek, Mitchell S V Elkind, Bernadette Boden-Albala, Chuanhui Dong, Ying Kuen Cheung, Yaakov Stern, Ralph L Sacco, Clinton B Wright
OBJECTIVE: To examine frequent snoring, sleepiness, and sleep duration with baseline and longitudinal performance on neuropsychological (NP) battery. METHODS: The analysis consists of 711 participants of the Northern Manhattan Study (NOMAS) with sleep data and NP assessment (age 63 ± 8 years, 62% women, 18% white, 17% black, 67% Hispanic) and 687 with repeat NP testing (at a mean of 6 ± 2 years). The main exposures were snoring, sleepiness, and sleep duration obtained during annual follow-up...
October 4, 2016: Neurology
Nao Souma, Tamara Isakova, David Lipiszko, Ralph L Sacco, Mitchell S V Elkind, Janet T DeRosa, Shonni J Silverberg, Armando J Mendez, Chuanhui Dong, Clinton B Wright, Myles Wolf
CONTEXT: An elevated fibroblast growth factor (FGF) 23 is an independent risk factor for cardiovascular disease and mortality in patients with kidney disease. The relationship between FGF23 and cause-specific mortality in the general population is unknown. OBJECTIVE: To investigate the association of elevated FGF23 with the risk of cause-specific mortality in a racially and ethnically diverse urban general population. DESIGN, SETTING, PARTICIPANTS: The Northern Manhattan Study is a population-based prospective cohort study...
October 2016: Journal of Clinical Endocrinology and Metabolism
Frederica Perera, Emily L Roen Nolte, Ya Wang, Amy E Margolis, Antonia M Calafat, Shuang Wang, Wanda Garcia, Lori A Hoepner, Bradley S Peterson, Virginia Rauh, Julie Herbstman
BACKGROUND: Experimental and epidemiological studies suggest that gestational exposure to Bisphenol A (BPA), an ubiquitous endocrine disrupting chemical, may lead to neurobehavioral problems in childhood; however, not all results have been consistent. We previously reported a positive association between prenatal BPA exposure and symptoms of anxiety/depression reported by the mother at child age 7-9 years in boys, but not girls. OBJECTIVES: Here, in the same birth cohort, we investigated the association of prenatal BPA exposure with symptoms of depression and anxiety self-reported by the 10-12 year olds, hypothesizing that we would observe sex-specific differences in anxiety and depressive symptoms...
November 2016: Environmental Research
Clinton B Wright, Chuanhui Dong, Michelle R Caunca, Janet DeRosa, Ying Kuen Cheng, Tatjana Rundek, Mitchell S V Elkind, Charles DeCarli, Ralph L Sacco
BACKGROUND: Brain magnetic resonance imaging (MRI) allows researchers to observe structural pathology that may predict cognitive decline. Some populations are less accessible through traditional in-person visits, and may be under-represented in the literature. METHODS: We examined white matter hyperintensity volume (WMHV) and cerebral parenchymal fraction (CPF) as predictors of cognitive decline measured by a modified Telephone Interview for Cognitive Status (TICS-m) in the Northern Manhattan Stroke Study, a racially and ethnically diverse cohort study...
July 27, 2016: Alzheimer Disease and Associated Disorders
Hannah Gardener, Teshamae Monteith, Tatjana Rundek, Clinton B Wright, Mitchell S V Elkind, Ralph L Sacco
OBJECTIVE: To investigate the association between migraine and hypertension in the Northern Manhattan Study (NOMAS), a multiethnic community-based sample. DESIGN: Cross-sectional cohort study. PARTICIPANTS: 1338 NOMAS participants (mean age 68.1 ± 9.6 years, 37% male, 15% non-Hispanic White, 19% non-Hispanic Black, 67% Hispanic). SETTING: Northern Manhattan community. INTERVENTION: Participants were assessed for migraine symptoms using a self-report questionnaire based on criteria from the International Classification of Headache Disorders...
2016: Ethnicity & Disease
A H Beecham, L Wang, N Vasudeva, Z Liu, C Dong, P J Goldschmidt-Clermont, M A Pericak-Vance, T Rundek, D Seo, S H Blanton, R L Sacco, G W Beecham
Hypertension is strongly influenced by genetic factors. Although hypertension prevalence in some Hispanic sub-populations is greater than in non-Hispanic whites, genetic studies on hypertension have focused primarily on samples of European descent. A recent meta-analysis of 200 000 individuals of European descent identified 29 common genetic variants that influence blood pressure, and a genetic risk score derived from the 29 variants has been proposed. We sought to evaluate the utility of this genetic risk score in Hispanics...
June 2, 2016: Journal of Human Hypertension
Mira Katan, Yeseon P Moon, Myunghee C Paik, Beat Mueller, Andreas Huber, Ralph L Sacco, Mitchell S V Elkind
BACKGROUND AND PURPOSE: Chronic infections and neuroendocrine dysfunction may be risk factors for ischemic stroke (IS). We hypothesized that selected blood biomarkers of infection (procalcitonin [PCT]), hypothalamic-pituitary-axis function (copeptin), and hemodynamic dysfunction (midregional proatrial natriuretic peptide [MRproANP]) are associated with incident IS risk in the multiethnic, urban Northern Manhattan Study (NOMAS) cohort. METHODS: A nested case-control study was performed among initially stroke-free participants...
July 2016: Stroke; a Journal of Cerebral Circulation
Eduard Tiozzo, Hannah Gardener, Barry I Hudson, Chuanhui Dong, David Della-Morte, Milita Crisby, Ronald B Goldberg, Mitchell S V Elkind, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Moise Desvarieux, Tatjana Rundek
BACKGROUND AND PURPOSE: Recent drug trials have challenged the high-density lipoprotein-cholesterol (HDL-C) antiatherosclerotic hypothesis, suggesting that total level of HDL-C may not be the best target for intervention. HDL-C subfractions may be better markers of vascular risk than total levels of HDL-C. The objective of this cross-sectional study was to investigate the relationship between HDL2-C and HDL3-C fractions and carotid intima-media thickness (cIMT) in the population-based Northern Manhattan Study...
June 2016: Stroke; a Journal of Cerebral Circulation
Carlos Jose Rodriguez, TanYa M Gwathmey, Zhezhen Jin, Joseph Schwartz, Bettina M Beech, Ralph L Sacco, Marco R Di Tullio, Shunichi Homma
OBJECTIVE: Little is known about the relationship of perceived racism to ambulatory blood pressure (ABP) in Hispanics. We explored possible associations between ABP nocturnal dipping and perceived racism in a Hispanic cohort. METHODS: Participants included 180 community-dwelling Hispanics from the Northern Manhattan Study. Measures included perceived racism, socioeconomic status, social support, and ABP monitoring. Nocturnal ABP nondipping was defined as a less than 10% decline in the average asleep systolic blood pressure relative to the awake systolic blood pressure...
September 2016: Psychosomatic Medicine
Joshua Z Willey, Hannah Gardener, Michelle R Caunca, Yeseon Park Moon, Chuanhui Dong, Yuen K Cheung, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright
OBJECTIVE: Because leisure-time physical activity (LTPA) is protective against incident dementia, we hypothesized that LTPA is protective against decline in domain-specific cognitive performance. METHODS: As part of the Northern Manhattan Study, LTPA was ascertained at enrollment using a validated in-person questionnaire. We assessed cognition in participants in the Northern Manhattan Study MRI substudy using a standard neuropsychological examination (NPE) (n = 1,228), and a repeat examination was performed 5 years later (n = 876)...
May 17, 2016: Neurology
Hannah Gardener, Clinton B Wright, Chuanhui Dong, Ken Cheung, Janet DeRosa, Micaela Nannery, Yaakov Stern, Mitchell S V Elkind, Ralph L Sacco
BACKGROUND: The American Heart Association defined target levels for 7 cardiovascular health (CVH) factors: smoking, body mass index, physical activity, diet, blood pressure, cholesterol, and glucose. We hypothesized that a greater number of American Heart Association ideal CVH metrics would be associated with less decline in cognitive performance in our multiethnic population. METHODS AND RESULTS: A subsample from the population-based Northern Manhattan Study underwent repeated neuropsychological testing (mean interval 6±2 years)...
March 16, 2016: Journal of the American Heart Association
Clinton B Wright, Nirav H Shah, Armando J Mendez, Janet T DeRosa, Mitsuhiro Yoshita, Mitchell S V Elkind, Ralph L Sacco, Charles DeCarli, Tatjana Rundek, Shonni Silverberg, Chuanhui Dong, Myles Wolf
BACKGROUND AND PURPOSE: Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear. METHODS: We used multivariable linear and logistic regression to evaluate associations between FGF23, continuously and by quartiles, with white matter hyperintensity volume, expressed as percent intracranial volume (%ICV), and subclinical brain infarction (SBI) in a community-based stroke-free sample...
April 2016: Stroke; a Journal of Cerebral Circulation
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