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atrial cardiomyopathy

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https://www.readbyqxmd.com/read/29668926/right-atrial-and-ventricular-echocardiographic-strain-analysis-predicts-requirement-for-right-ventricular-support-after-left-ventricular-assist-device-implantation
#1
Dafni Charisopoulou, Nicholas R Banner, Camil Demetrescu, Andre R Simon, Shelley Rahman Haley
Aims: The need for right ventricular assist device (RVAD) support after left ventricular assist device (LVAD) therapy is associated with increased morbidity and mortality. We used 2D echocardiographic strain analysis to assess right atrial (RA) and right ventricular (RV) mechanics and predict the need for RV mechanical support after LVAD implantation. Methods and results: Seventy advanced chronic heart failure (ACHF) patients [59 male, age 47 ± 12 years, 79% dilated cardiomyopathy, left ventricular ejection fraction 23 ± 10%] received continuous-flow LVAD as a bridge to transplantation over an 18 month period...
April 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29663123/creation-of-a-restrictive-atrial-communication-in-heart-failure-with-preserved-and-mid-range-ejection-fraction-effective-palliation-of-left-atrial-hypertension-and-pulmonary-congestion
#2
Anna Bauer, Markus Khalil, Monika Lüdemann, Jürgen Bauer, Anoosh Esmaeili, Roberta De-Rosa, Norbert F Voelkel, Hakan Akintuerk, Dietmar Schranz
BACKGROUND: Left atrial decompression is considered in patients with symptomatic heart failure with preserved ejection fraction (HFpEF). We aimed to evaluate the feasibility and efficacy of transcatheter generation of a restrictive atrial septum communication to manage HFpEF from infancy to adulthood with cardiomyopathy and congenital heart defect. METHODS AND RESULTS: From June 2009 to December 2016, 24 patients (50% with an age less than 16 years) with HFpEF were palliated; NYHA-/Ross class IV (n = 10); median systemic ventricular ejection fraction 64 (range 35-78) %...
April 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29660794/diagnostic-utility-of-cardiac-troponin-i-in-cats-with-hypertrophic-cardiomyopathy
#3
Yasutomo Hori, Masayuki Iguchi, Yasuhiro Heishima, Yohei Yamashita, Kensuke Nakamura, Atsushi Hirakawa, Akihito Kitade, Toshiki Ibaragi, Michio Katagi, Tamotsu Sawada, Masashi Yuki, Nobuyuki Kanno, Haruki Inaba, Noriko Isayama, Hideyuki Onodera, Naoki Iwasa, Mikio Kino, Mikihiro Narukawa, Syuhei Uchida
BACKGROUND: Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats. OBJECTIVE: To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM. ANIMALS: Clinically healthy cats (n = 88) and cats with HCM (n = 93). METHODS: Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29659778/impact-of-diabetes-mellitus-on-the-contractile-properties-of-the-left-and-right-atrial-myofilaments
#4
Constanze Bening, Khaled Alhussini, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Hamouda, Dejan Radakovic, Christoph Schimmer, Grzegorz Hirnle, Rainer Leyh
OBJECTIVES: The incidence of diabetes mellitus in patients with ischaemic cardiomyopathy is increasing. To evaluate the impact of diabetes mellitus on contractility, we examined the calcium-induced force in left and right atrial myofilaments of patients with and without diabetes. METHODS: We included 149 patients (106 without diabetes, 43 with diabetes), scheduled for elective coronary artery bypass grafting from August 2016 to June 2017. The left and right atria were excised and prepared for skinned fibre measurements (pCa-force curve)...
April 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29648690/incremental-value-of-left-atrial-active-function-measured-by-speckle-tracking-echocardiography-in-patients-with-hypertrophic-cardiomyopathy
#5
Kaori Fujimoto, Katsuji Inoue, Makoto Saito, Haruhiko Higashi, Tamami Kono, Teruyoshi Uetani, Jun Aono, Takayuki Nagai, Kazuhisa Nishimura, Jun Suzuki, Takafumi Okura, Shuntaro Ikeda, Satoshi Nakatani, Jitsuo Higaki
PURPOSE: Hypertrophic cardiomyopathy (HCM) impairs left ventricular (LV) diastolic function leading to left atrial (LA) dilatation. Because Doppler echocardiography cannot accurately assess LV diastolic function in hearts with heterogeneous hypertrophy, assessment of LA function might be useful for risk stratification of patients with HCM. This study aimed to elucidate the impact of LA function on outcome in patients with patients. METHODS: Seventy-six patients with HCM who underwent echocardiographic and cardiac magnetic resonance imaging were retrospectively enrolled...
April 12, 2018: Echocardiography
https://www.readbyqxmd.com/read/29626283/left-ventricular-energy-loss-and-wall-shear-stress-assessed-by-vector-flow-mapping-in-patients-with-hypertrophic-cardiomyopathy
#6
Ling Ji, Wenzhi Hu, Yonghong Yong, Hongping Wu, Lei Zhou, Di Xu
The aim of this study was to assess left ventricular (LV) summation of energy loss (EL-SUM), average energy loss (EL-AVE) and wall shear stress (WSS) using vector flow mapping (VFM) in patients with hypertrophic cardiomyopathy (HCM). Forty HCM patients, and 40 controls were evaluated by transthoracic echocardiography. Conventional echocardiographic parameters, summation and average of energy loss (EL-total, EL-base, EL-mid and EL-apex), and WSS in each segment were calculated at different phases. Compared with controls, conventional diastolic measurements were impaired in HCM patients...
April 6, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29622585/prevalence-and-progression-of-late-gadolinium-enhancement-in-children-and-adolescents-with-hypertrophic-cardiomyopathy
#7
Anna Axelsson Raja, Hoshang Farhad, Anne Marie Valente, John-Paul Couce, John Lynn Jefferies, Henning Bundgaard, Kenneth Zahka, Harry Lever, Anne M Murphy, Euan Ashley, Sharlene M Day, Mark V Sherrid, Ling Shi, David A Bluemke, Charles E Canter, Steven D Colan, Carolyn Y Ho
Background -Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is believed to represent dense replacement fibrosis. It is seen in ~60% of adult patients with hypertrophic cardiomyopathy (HCM). However, the prevalence of LGE in children and adolescents with HCM is not well established. Additionally, longitudinal studies describing the development and evolution of LGE in pediatric HCM are lacking. This study assesses the prevalence, progression, and clinical correlations of LGE in children and adolescents with, or genetically predisposed to, HCM...
April 5, 2018: Circulation
https://www.readbyqxmd.com/read/29605142/short-and-long-term-outcomes-of-patients-with-hypertrophic-cardiomyopathy-after-noncardiac-surgery-a-single-center-retrospective-study
#8
Tomoaki Yatabe, Toru Kubo, Hiroaki Kitaoka, Masataka Yokoyama
OBJECTIVE: Although several studies have demonstrated that noncardiac surgery in patients with hypertrophic cardiomyopathy (HCM) is safe, the long-term outcomes remain unclear. Therefore, the authors investigated the postoperative long-term outcomes of patients with HCM who underwent noncardiac surgery at their hospital. DESIGN: Retrospective review. SETTING: Single university hospital. PARTICIPANTS: Seventy-two consecutive patients with HCM who underwent noncardiac surgery...
March 6, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29604289/effect-of-spironolactone-on-myocardial-fibrosis-and-other-clinical-variables-in-patients-with-hypertrophic-cardiomyopathy-a-prospective-randomized-trial
#9
Martin S Maron, Raymond H Chan, Navin Kapur, Iris J Jaffe, Adam P McGraw, Raj Kerur, Barry J Maron, James E Udelson
BACKGROUND: Myocardial fibrosis has proved to be an important marker and determinant in the pathogenesis of hypertrophic cardiomyopathy . In particular, scar formation, if substantial, can promote ventricular tachyarrhythmias or progressive heart failure in the absence ofleft ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis would be potentially advantageous to hypertrophic cardiomyopathy patients. METHODS: Eligible hypertrophic cardiomyopathy patients were randomized 1:1 in a prospective double-blind fashion to spironolactone 50 mg or placebo to be taken over a 12-month period...
March 28, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29604277/jip3-deficiency-attenuates-cardiac-hypertrophy-by-suppression-of-jnk-pathway
#10
Qinghua Ma, Yuxiu Liu, Lianghua Chen
Pathological cardiac hypertrophy is a leading cause of morbidity and mortality worldwide; however, our understanding of the molecular mechanisms revealing the disease is still unclear. In the present study, we suggested that c-Jun N-terminal kinase (JNK)-interacting protein 3 (JIP3), involved in various cellular processes, played an essential role in regulating pathological cardiac hypertrophy through in vivo and in vitro studies. JIP3 was highly expressed in human hearts with hypertrophic cardiomyopathy (HCM), and in mouse hypertrophic hearts...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29602943/hemoptysis-after-cardiomems-implantation-case-report-and-review
#11
Aniket S Rali, Zubair Shah, Andrew J Sauer, Kamal Gupta
BACKGROUND The CardioMEMS heart failure system is a small sensor that is placed in a branch pulmonary artery for ambulatory monitoring of pulmonary artery pressures. CardioMEMS has been approved for use in the United States in patients with New York Heart Association (NYHA) class III heart failure and frequent hospitalizations. In this report we describe a patient who had hemoptysis after CardioMEMS implantation. Further, we discuss possible etiologies for the occurrence of hemoptysis and suggest strategies to minimize this risk...
March 31, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29600790/biatrial-electrical-and-structural-atrial-changes-in-heart-failure-electroanatomic-mapping-in-persistent-atrial-fibrillation-in-humans
#12
Sandeep Prabhu, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
OBJECTIVES: This study sought to characterize the biatrial substrate in heart failure (HF) and persistent atrial fibrillation (PeAF). BACKGROUND: Atrial fibrillation (AF) and HF frequently coexist; however, the contribution of HF to the biatrial substrate in PeAF is unclear. METHODS: Consecutive patients with PeAF and normal left ventricular (NLV) systolic function (left ventricular ejection fraction [LVEF] >55%) or idiopathic cardiomyopathy (LVEF ≤45%) undergoing AF ablation were enrolled...
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29596445/time-spent-with-cats-is-never-wasted-lessons-learned-from-feline-acromegalic-cardiomyopathy-a-naturally-occurring-animal-model-of-the-human-disease
#13
Kieran Borgeat, Stijn J M Niessen, Lois Wilkie, Norelene Harrington, David B Church, Virginia Luis Fuentes, David J Connolly
BACKGROUND: In humans, acromegaly due to a pituitary somatotrophic adenoma is a recognized cause of increased left ventricular (LV) mass. Acromegalic cardiomyopathy is incompletely understood, and represents a major cause of morbidity and mortality. We describe the clinical, echocardiographic and histopathologic features of naturally occurring feline acromegalic cardiomyopathy, an emerging disease among domestic cats. METHODS: Cats with confirmed hypersomatotropism (IGF-1>1000ng/ml and pituitary mass; n = 67) were prospectively recruited, as were two control groups: diabetics (IGF-1<800ng/ml; n = 24) and healthy cats without known endocrinopathy or cardiovascular disease (n = 16)...
2018: PloS One
https://www.readbyqxmd.com/read/29590384/atrial-remodelling-and-function-implications-for-atrial-fibrillation-surgery
#14
Stefano Benussi, Gijs E de Maat
The exact mechanism of atrial fibrillation (AF) is still incompletely understood. A number of alterations that impact focal electrical discharge, the atrial substrate and modulating factors contribute to its pathogenesis. Atrial remodelling (resulting in atrial cardiomyopathy) sets the stage for AF development. Once present, AF results in the loss of synchronized atrial contraction, which affects ventricular filling and atrial reservoir and conduit functions. Passive atrial function is particularly important in patients with left ventricular diastolic dysfunction...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29584721/multimorbidity-in-patients-with-heart-failure-from-11-asian-regions-a-prospective-cohort-study-using-the-asian-hf-registry
#15
Jasper Tromp, Wan Ting Tay, Wouter Ouwerkerk, Tiew-Hwa Katherine Teng, Jonathan Yap, Michael R MacDonald, Kirsten Leineweber, John J V McMurray, Michael R Zile, Inder S Anand, Carolyn S P Lam
BACKGROUND: Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF and their association with patients' quality of life (QoL) and health outcomes. METHODS AND FINDINGS: We used data on 6,480 patients with chronic HF (1,204 with preserved ejection fraction) enrolled between 1 October 2012 and 6 October 2016 in the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29581222/device-therapies-among-patients-receiving-primary-prevention-implantable-cardioverter-defibrillators-in-the-cardiovascular-research-network
#16
Robert T Greenlee, Alan S Go, Pamela N Peterson, Andrea E Cassidy-Bushrow, Charles Gaber, Romel Garcia-Montilla, Karen A Glenn, Nigel Gupta, Jerry H Gurwitz, Stephen C Hammill, John J Hayes, Alan Kadish, David J Magid, David D McManus, Deborah Multerer, J David Powers, Liza M Reifler, Kristi Reynolds, Claudio Schuger, Param P Sharma, David H Smith, Mary Suits, Sue Hee Sung, Paul D Varosy, Humberto J Vidaillet, Frederick A Masoudi
BACKGROUND: Primary prevention implantable cardioverter-defibrillators (ICDs) reduce mortality in selected patients with left ventricular systolic dysfunction by delivering therapies (antitachycardia pacing or shocks) to terminate potentially lethal arrhythmias; inappropriate therapies also occur. We assessed device therapies among adults receiving primary prevention ICDs in 7 healthcare systems. METHODS AND RESULTS: We linked medical record data, adjudicated device therapies, and the National Cardiovascular Data Registry ICD Registry...
March 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29580630/feasibility-of-performing-radiofrequency-catheter-ablation-and-endomyocardial-biopsy-in-the-same-setting
#17
J William Schleifer, Kevin K Manocha, Samuel J Asirvatham, Peter A Noseworthy, Rajiv Gulati, Paul A Friedman, Malini Madhavan, Thomas M Munger, Leslie T Cooper, Guy S Reeder, David R Holmes, Suraj Kapa
In patients with unexplained cardiomyopathy, electroanatomical mapping can identify abnormal tissue to target during electrophysiology-guided endomyocardial biopsy (EP-guided EMB). The objective of this study is to determine whether catheter ablation performed in the same setting as EP-guided EMB increases procedural risk. Sixty-seven patients (mean age 54.4 ± 13.8, 57% male) undergoing EP-guided EMB were included. Radiofrequency catheter ablation was performed in 17 patients (25%) for ventricular arrhythmias and in 2 (3%) for typical atrial flutter...
March 5, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29579189/cardiac-voltage-gated-sodium-channel-mutations-associated-with-left-atrial-dysfunction-and-stroke-in-children
#18
Adrien Moreau, Alexandre Janin, Gilles Millat, Philippe Chevalier
Aims: Cardiac atrial arrhythmias are the most common type of heart rhythm disorders. Its genetic elucidation remains challenging with poor understanding of cellular and molecular processes. These arrhythmias usually affect elderly population but in rare cases, young children may also suffer from such electrical diseases. Severe complications, including stroke, are commonly age related. This study aims to identify a genetic link between electro-mechanic atrial dysfunction and stroke in children...
March 22, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29570041/percutaneous-left-atrial-appendage-occlusion-in-a-lamin-a-c-gene-mutation-related-cardiomyopathy-patient-with-persistent-left-atrial-appendage-thrombus-a-case-report
#19
Frederic De Roeck, Benjamin Scott, Stefan Verheye, Paul Vermeersch
No abstract text is available yet for this article.
March 23, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29562910/left-ventricular-hypertrophy-diagnosed-after-a-stroke-a-case-report
#20
Wilfred Ifeanyi Umeojiako, Ritesh Kanyal
BACKGROUND: Stroke is a recognized clinical course of hypertrophic cardiomyopathy. This interesting case showed notable difference on the electrocardiogram of a patient 4 months prior to suffering a stroke and 10 days after suffering a stroke. The pre-stroke electrocardiogram showed atrial fibrillation with a narrow QRS complex, while the post-stroke electrocardiogram showed marked left ventricular hypertrophy. Left ventricular hypertrophy was diagnosed using the Sokolow-Lyon indices...
March 22, 2018: Journal of Medical Case Reports
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