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https://www.readbyqxmd.com/read/28339349/is-triclosan-a-neurotoxic-agent
#1
Joanna A Ruszkiewicz, Shaojun Li, Maliya B Rodriguez, Michael Aschner
Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s. Given its broad usage as an antiseptic TCS is present ubiquitously in the environment. Trace levels of TCS continue to be detected in many organisms, and it has been shown to be particularly toxic to aquatic species. The mechanisms underlying TCS-mediated toxicity include hormone dyshomeostasis, induction of oxidative stress, apoptosis and inflammation. Although TCS has been considered to be non-toxic to mammals, the adverse effects of continuous, long-term and low concentration exposure remain unknown...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28132117/evaluation-of-antimicrobial-persistent-activity-of-alcohol-based-hand-antiseptics-against-bacterial-contamination
#2
R M López-Gigosos, E Mariscal-López, M Gutierrez-Bedmar, A García-Rodriguez, A Mariscal
The purpose of this study was to evaluate persistent activity of three alcohol-based antiseptics widely used in the clinical routine containing chlorhexidine, triclosan or mecetronium after hand disinfection. Four tests were used to evaluate the antimicrobial activity of antiseptics on: (i) resident microbiota; (ii) nutrient agar plates (NAP) subsequently inoculated with a test organism; and transient microbiota acquired by contact with dry hands (iii), or (iv) a wet inert surface that had been artificially contaminated...
January 28, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27986361/systematic-review-and-meta-analysis-of-the-effectiveness-of-antiseptic-agents-for-meatal-cleaning-in-the-prevention-of-catheter-associated-urinary-tract-infections
#3
REVIEW
O Fasugba, J Koerner, B G Mitchell, A Gardner
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are among the most common healthcare-associated infections. Antiseptic cleaning of the meatal area before and during catheter use may reduce the risk of CAUTIs. AIM: To undertake a systematic review of the literature and meta-analysis of studies investigating the effectiveness of antiseptic cleaning before urinary catheter insertion and during catheter use for prevention of CAUTIs. METHODS: Electronic databases were searched to identify randomized controlled trials...
March 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27981857/effective-modified-conservative-tissue-preserving-protocol-to-treat-stage-i-axillary-hidradenitis-suppurativa-a-prospective-cohort-study-of-627-patients-with-five-years-follow-up
#4
Bader Hamza Shirah, Hamza Asaad Shirah
BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory cutaneous disorder that involves the infundibular terminal follicles in areas rich in apocrine glands and associated with the formation of abscesses and fistulating sinus. The clinical course is variable, and definitive evidence-based guidelines for the management are not well-established. Conservative treatment is controversial, and surgical excision is the recommended method. Herein, we aim to analyze the results of a modified conservative tissue preserving management protocol for stage I axillary hidradenitis suppurativa...
December 16, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27722057/triclosan-in-water-implications-for-human-and-environmental-health
#5
L W B Olaniyan, N Mkwetshana, A I Okoh
Triclosan (TCS) is a broad spectrum antibacterial agent present as an active ingredient in some personal care products such as soaps, toothpastes and sterilizers. It is an endocrine disrupting compound and its increasing presence in water resources as well as in biosolid-amended soils used in farming, its potential for bioaccumulation in fatty tissues and toxicity in aquatic organisms are a cause for concern to human and environmental health. TCS has also been detected in blood, breast milk, urine and nails of humans...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27585555/microbicidal-effects-of-plain-soap-vs-triclocarban-based-antibacterial-soap
#6
S A Kim, M S Rhee
The aim of this study was to determine the bactericidal effects of plain and antibacterial soap. The bactericidal effects of plain and antibacterial soap containing 0.3% triclocarban were examined against 10 Gram-positive and 10 Gram-negative bacterial strains after exposure at 22°C and 40°C for 20 s. Gram-negative bacteria were more susceptible to both soaps than Gram-positive bacteria. However, with one exception (Enterococcus faecalis ATCC 19433 at 40°C), there was no significant difference between the effects of medicated and non-medicated soap at either temperature...
November 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27573526/the-disinfect-initiative-decreasing-the-incidence-of-surgical-infections-in-gynecologic-oncology
#7
Jolyn S Taylor, Claire A Marten, Mark F Munsell, Charlotte C Sun, Kimberly A Potts, Jennifer K Burzawa, Alpa M Nick, Larissa A Meyer, Keith Myers, Diane C Bodurka, Thomas A Aloia, Charles F Levenback, David R Lairson, Kathleen M Schmeler
BACKGROUND: Surgical site infections (SSIs) lead to increased patient morbidity and healthcare costs. Our objective was to decrease the SSI rate following gynecologic surgery. METHODS: Adult patients undergoing abdominal surgery for gynecologic malignancy or benign disease received the following: patient education; preoperative antibacterial soap; appropriate antibiotic prophylaxis; change of gloves and use of clean instruments at surgical closure; surgical dressing for 48 h; and a post-discharge phone call...
February 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27500309/chemical-composition-and-antimicrobial-activity-of-fatty-acid-methyl-ester-of-quercus-leucotrichophora-fruits
#8
Ankita Sati, Sushil Chandra Sati, Nitin Sati, O P Sati
Natural fats and dietary oils are chief source of fatty acids and are well known to have antimicrobial activities against various microbes. The chemical composition and antimicrobial activities of fatty acids from fruits of white Oak (Quercus leucotrichophora) are yet unexplored and therefore the present study for the first time determines the fatty acid composition, and the antibacterial and antifungal activities of fatty acid methyl esters (FAME) of the white Oak plant found along the Himalayan region of Uttarakhand, India...
March 2017: Natural Product Research
https://www.readbyqxmd.com/read/27377698/the-cutaneous-microbiome-and-aspects-of-skin-antimicrobial-defense-system-resist-acute-treatment-with-topical-skin-cleansers
#9
Aimee M Two, Teruaki Nakatsuji, Paul F Kotol, Evangelia Arvanitidou, Laurence Du-Thumm, Tissa R Hata, Richard L Gallo
The human skin microbiome has been suggested to play an essential role in maintaining health by contributing to innate defense of the skin. These observations have inspired speculation that the use of common skin washing techniques may be detrimental to the epidermal antibacterial defense system by altering the microbiome. In this study, several common skin cleansers were used to wash human forearms and the short-term effect on the abundance of the antimicrobial peptide LL-37 and the abundance and diversity of bacterial DNA was measured...
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27047615/crowdsourced-data-indicate-widespread-multidrug-resistance-in-skin-flora-of-healthy-young-adults
#10
Scott Freeman, Nnadozie O Okoroafor, Christopher M Gast, Mikhail Koval, David Nowowiejski, Eileen O'Connor, Robert D Harrington, John W Parks, Ferric C Fang
In a laboratory exercise for undergraduate biology majors, students plated bacteria from swabs of their facial skin under conditions that selected for coagulase-negative Staphylococcus; added disks containing the antibiotics penicillin, oxacillin, tetracycline, and erythromycin; and measured zones of inhibition. Students also recorded demographic and lifestyle variables and merged this information with similar data collected from 9,000 other students who had contributed to the database from 2003 to 2011. Minimum inhibitory concentration (MIC) testing performed at the Harborview Medical Center Microbiology Laboratory (Seattle, WA) indicated a high degree of accuracy for student-generated data; species identification with a matrix-assisted laser desorption ionization (MALDI) Biotyper revealed that over 88% of the cells analyzed by students were S...
March 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/26944235/ximenia-caffra-sond-ximeniaceae-in-sub-saharan-africa-a-synthesis-and-review-of-its-medicinal-potential
#11
REVIEW
Alfred Maroyi
ETHNOPHARMACOLOGICAL RELEVANCE: Ximenia caffra Sond. (Ximeniaceae), commonly known as "sour plum" is traditionally used, both topically and orally to treat a wide range of human diseases and ailments such as wounds, sexually transmitted infections (STIs), infertility, stomach ache, fever, eye problems, diarrhoea, bilharzia, menorrhagia, malaria, intestinal worms, impotence and coughs. The bark and fruits are used by small-scale farmers as ethnoveterinary medicine to treat dermatophilosis, foot rot, saddle sores and control ectoparasites...
May 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26908126/prenatal-triclosan-exposure-and-anthropometric-measures-including-anogenital-distance-in-danish-infants
#12
Tina Harmer Lassen, Hanne Frederiksen, Henriette Boye Kyhl, Shanna H Swan, Katharina M Main, Anna-Maria Andersson, Dorte Vesterholm Lind, Steffen Husby, Christine Wohlfahrt-Veje, Niels E Skakkebæk, Tina Kold Jensen
BACKGROUND: Triclosan (TCS) is widely used as an antibacterial agent in consumer products such as hand soap and toothpaste, and human exposure is widespread. TCS is suspected of having endocrine-disrupting properties, but few human studies have examined the developmental effects of prenatal TCS exposure. OBJECTIVES: We prospectively examined associations between prenatal TCS exposure and anthropometric measures at birth and anogenital distance (AGD) at 3 months of age...
August 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/26867165/consumer-products-as-sources-of-chemical-exposures-to-children-case-study-of-triclosan
#13
REVIEW
Gary L Ginsberg, Sophie J Balk
PURPOSE OF REVIEW: Consumer products are often overlooked as sources of children's exposures to toxic chemicals. Various regulatory bodies have developed lists of chemicals of concern that can be found in products contacted by children. However, this information has not been summarized for health practitioners. This review organizes such chemicals and products into four categories, with the antibacterial agent triclosan used to illustrate the potential risks to children from a common ingredient in consumer products...
April 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/26844391/critical-assessment-of-the-ph-of-children-s-soap
#14
Bruna Rafaela Mendes, Danielle Midori Shimabukuro, Marjorie Uber, Kerstin Taniguchi Abagge
OBJECTIVE: To evaluate the pH value of children's antibacterial soaps and syndets used in children's baths and verify whether there is information regarding pH on the product label. METHODS: Quantitative, cross-sectional, analytical observational study that included ninety soap samples, both in bar and liquid presentations, as follows: 67 children's soap (group 1), 17 antibacterial soaps (group 2), and 6 syndets (group 3). Each sample had its pH measured after 1% dilution...
May 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/26832428/randomised-controlled-trial-of-topical-kanuka-honey-for-the-treatment-of-acne
#15
RANDOMIZED CONTROLLED TRIAL
Alex Semprini, Irene Braithwaite, Andrew Corin, Davitt Sheahan, Christopher Tofield, Colin Helm, Barney Montgomery, James Fingleton, Mark Weatherall, Richard Beasley
OBJECTIVE: To investigate the efficacy of Honevo, a topical 90% medical-grade kanuka honey, and 10% glycerine (honey product) as a treatment for facial acne. DESIGN: Randomised controlled trial with single blind assessment of primary outcome variable. SETTING: Outpatient primary care from 3 New Zealand localities. PARTICIPANTS: Of 136 participants aged between 16 and 40 years with a diagnosis of acne and baseline Investigator's Global Assessment (IGA) for acne score of ≥ 2...
February 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/19187682/-efficiency-versus-quality-in-the-nhs-in-portugal-methodologies-for-evaluation
#16
COMPARATIVE STUDY
Maria do Rosário Giraldes
To proceed to the evaluation of the efficiency and quality in the NHS, based in methodologies of evaluation of management, indicators of benchmarking and indicators of process and outcome. The 1980 and 1990 decades have seen the proliferation of all forms of process indicators as a way to control health services. It is not a coincidence that the increase in managed care has been accompanied by an explosion of process indicators, as it has happened in the health system of the USA. More recently the attention has turned away from measures of performance, which measure the process (what has been done) to those which measure outcomes (what was the result)...
September 2008: Acta Médica Portuguesa
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