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Basedow graves

Zdeněk Fryšák, David Karásek, Milan Halenka
Endocrine orbitopathy (EO) must be understood mainly as a result of oxidative stress. The pathological process finally affects both the appearance and vision of the patient. In the case of inappropriate or late treatment or lack of patient cooperation, it significantly influences the quality of life of those affected. In spite of the sophisticated dia-gnostic algorithms, in some cases it is difficult to confirm the diagnosis of EO. The range of laboratory methods, the essential part of the diagnostic process, has only recently been extended by the possibility of quantification of specific, stimulating immunoglobulins (TSI)...
2016: Vnitr̆ní Lékar̆ství
Nassim Essabah Haraj, Hayat Ahandar, Siham El Aziz, Asma Chadli
The presence of hyperthyroidism is no longer an insurance against the occurrence of thyroid cancer. The combination of the two is common. This is a retrospective study of 355 files of patients followed for differentiated thyroid cancer in the endocrinology department at CHU IBN ROCHD from 1986 to 2014. 12 of those patients were followed for hyperthyroidism, and a fortuitous association with differentiated thyroid cancer was found during the anatomopathological exam, giving us a 3.38% prevalence. The average age of discovery is 44...
2016: Pan African Medical Journal
Adriana Handra-Luca, Ema Dragoescu
Thyroid lymphoepithelial complexes (LECos) are rare, being reported in lymphoma, Graves-Basedow disease, Hashimoto thyroiditis, pericarcinomatous thyroid or in the context of branchial cleft-like cysts. Here we report immunohistochemical expression of cytokeratin 5/6, P63 and TTF1 in 6 cases of thyroid LECos. Two cases had carbimazole treatment for hyperthyroidia and Graves disease. Anti-thyroglobulin, -thyroperoxidase or -TSH antibodies were detected in 4 cases. NSAID or poviodone iodine allergy were present in 2 cases...
August 2016: Annals of Diagnostic Pathology
Roberto Ria, Vittorio Simeon, Assunta Melaccio, Giovanna Di Meo, Stefania Trino, Carmela Mazzoccoli, Ilaria Saltarella, Aurelia Lamanuzzi, Annalisa Morano, Angela Gurrado, Alessandro Pasculli, Gaetano Lastilla, Pellegrino Musto, Antonia Reale, Franco Dammacco, Angelo Vacca, Mario Testini
Gene expression profiling (GEP) of normal thyroid tissue from 43 patients with thyroid carcinoma, 6 with thyroid adenoma, 42 with multinodular goiter, and 6 with Graves-Basedow disease was carried out with the aim of achieving a better understanding of the genetic mechanisms underlying the role of normal cells surrounding the tumor in the thyroid cancer progression. Unsupervised and supervised analyses were performed to compare samples from neoplastic and non-neoplastic diseases. GEP and subsequent RT-PCR analysis identified 28 differentially expressed genes...
May 17, 2016: Oncotarget
R Amri, N Mtaaouä, H Sehli, B Ben Ammou, I Ben Ahmed, N Riden, H Tounsi, R Jazi
OBJECTIFS: La maladie de basedow est une forme clinique de l'hyperthyroïdie qui peut être révélée par un amaigrissement, une exophtalmie, des diarrhées et des troubles du rythme cardiaque. MéTHODES: Nous rapportons une complication inhabituelle faisant révéler la maladie. RéSULTATS: Patient âgé de 34 ans sans antécédents pathologiques notables qui consulte aux urgences pour dysarthrie avec hémiparésie droite. Le scanner cérébral a objectivé une lésion ischémique temporopariétale gauche, l'ECG a montré une ACFA, qui a été réduite médicalement...
December 2015: Annales de Cardiologie et D'angéiologie
L Smith, T Kemp, C H van der Meyden, C-M Schutte
Thyrotoxic myopathy frequently occurs in clinical practice; however, the association of hyperthyroidism with a flaccid, areflexic paraplegia, so-called Basedow paraplegia, appears to represent a controversial and doubtful entity. An 18-year-old female with undiagnosed and untreated Graves’ disease presented with acute onset of global weakness predominantly in the lower limbs, but also affecting the upper limbs. The weakness was accompanied by hypotonia and areflexia. Clinically, the patient had a goitre and signs of thyroid ocular disease...
October 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
M Barbuscia, A Querci, A Tonante, D Paparo, F Taranto, A Ilacqua, E Gagliano, A Milone
In the present study the authors, after a short historical description of the Basedow-Graves' disease, describe their case-study gathered over the last five years. They mention the most widely accepted hypothesis regarding disease's etiology, strongly linked to autoimmune disorders, and the role that some viral agents (Coksackie B and HTLV-II) may have in initiating autoantibody production and T cells activation in genetically predisposed individuals. Basic and clinical aspects of the diagnosis and disease treatment, highlighting the use of thyroidectomy, are addressed...
May 2015: Il Giornale di Chirurgia
Peter Laurberg, S L Andersen
Thyroid hormones are essential development factors and maternal thyroid dysfunction may cause pregnancy complications and diseases in the fetus/child. In the present review we discuss new data on the incidence of Graves'-Basedow disease (GBD) in and around pregnancy, and how hyperthyroidism may affect the risk of spontaneous abortion and stillbirth. A special concern in pregnant women is the potential side effects from the use of antithyroid drugs (ATDs). One type of side effects is the allergic/toxic reactions to the drugs, which seem to be similar in and outside pregnancy, and another is that ATDs tend to over treat the fetus when the mother with GBD is made euthyroid...
2015: Nuklearmedizin. Nuclear Medicine
Anna Kawicka, Bożena Regulska-Ilow, Bożena Regulska-Ilow
In recent years, the authors of epidemiological studies have documented that autoimmune diseases are a major problem of modern society and are classified as diseases of civilization. Autoimmune thyroid diseases (ATDs) are caused by an abnormal immune response to autoantigens present in the thyroid gland - they often coexist with other autoimmune diseases. The most common dysfunctions of the thyroid gland are hypothyroidism, Graves-Basedow disease and Hashimoto's disease. Hashimoto's thyroiditis can be the main cause of primary hypothyroidism of the thyroid gland...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
Letiţia Leuştean, Cristina Preda, Maria-Christina Ungureanu, R Dănilă, Voichiţa Mogoş, Cipriana Stefănescu, Carmen Vulpoi
Graves' disease is the most common form of hyperthyroidism, accounting for 60-80% of all cases of thyrotoxicosis. If left untreated, it may lead to severe thyrotoxicosis with cardiovascular, ocular, psychiatric complication, and in extreme cases thyrotoxic crisis with a high mortality rate. We present the case of a 50-years-old woman diagnosed in another service with Graves' disease and treated for many years with antithyroid drugs (ATDs), admitted to our service for a relapse due to treatment discontinuation...
October 2014: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Seisuke Ota, Akinori Kasahara, Shoko Tada, Takehiro Tanaka, Sachio Umena, Haruka Fukatsu, Toshio Noguchi, Tadashi Matsumura
A 56-year-old female initially visited an otorhinolaryngologist because of an impaired sense of taste in September, 2010 and was referred to our facility in October, 2010. She was diagnosed with Basedow's disease for which she underwent subtotal thyroidectomy in 1984 and arthritis involving multiple joints, primarily affecting her hands. In addition, the anticentromere antibody (ACA) level was markedly high. On physical examination, alopecia as well as hyperpigmentation of the dorsum of the hands and back was observed...
February 2015: Clinical Journal of Gastroenterology
Adriana Handra-Luca
The thymus-parathyroid unit (TPU) occurring in adults is rare.The main symptoms and important clinical findings are as follows: 2 patients presented with neomercazole-resistant Basedow-Graves disease. A third patient presented with thyroid nodules and a fourth patient with a neck mass after thyroid resection for medullary thyroid carcinoma.The main diagnoses were those of thyroid nodules (either in the context of goiter, or not). In the fourth case the diagnosis was of thyroid medullary carcinoma recurrence in the neck...
December 2014: Medicine (Baltimore)
Shunsuke Kikuchi, Toshiyasu Ogata, Jiro Fukae, Jun Tsugawa, Shinji Ouma, Makito Tanabe, Toshihiko Yanase, Yoshio Tsuboi
A 57-year-old female developed dizziness and forgetfulness several days before admission. She was admitted to our hospital because of a headache and nausea. On admission, she had a mild disturbance of consciousness and right hemiparesis. Initial MR imaging revealed multiple infarctions in the acute-to-subacute phases in the right cerebellum, left occipital lobe, and bilateral parietal lobes. Her electrocardiogram showed atrial fibrillation and transesophageal echocardiography revealed the presence of a thrombus at the left atrial appendage, suggesting that she suffered from cardioembolic stroke...
December 2014: Brain and Nerve, Shinkei Kenkyū No Shinpo
A V Gostimskiĭ, A F Romanchishen, S S Peredereev
No abstract text is available yet for this article.
2014: Vestnik Khirurgii Imeni I. I. Grekova
Matthew J Lynch, Noel W F Woodford
Graves' disease is the most common cause of hyperthyroidism and is classically characterized by the clinical triad of diffuse toxic goiter, infiltrative ophthalmopathy with exophthalmos and an infiltrative dermopathy. While the name of the Irishman Robert Graves has received the eponymous honor, the first description of the condition in the English language can be attributed to the Englishman Caleb Perry, while in continental Europe the entity in name once honored Karl von Basedow. We present the case of a previously well 43 year old woman who presented in supraventricular tachycardia and acute pulmonary edema and died despite treatment and without a diagnosis for cause of death...
September 2014: Forensic Science, Medicine, and Pathology
J Villar Jiménez, A E Ruiz Serrato, C Bautista Galán, M Á Guerrero León
Thyrotoxic hypokalemic periodic paralysis is an uncommon complication of thyrotoxicosis, characterized by attacks of generalized muscular weakness associated with hypokalemia in patients with hyperthyroidism, most frequently with Graves-Basedow disease. Treatment with antithyroid drugs and potassium supplements reversed the symptoms and the episodes of acute muscular weakness did not reappear.
November 2013: Semergen
Malgorzata Anna Basinska, Anna Andruszkiewicz
BACKGROUND: Adaptation to a chronic somatic disease depends on a variety of factors, including belief in health locus of control. OBJECTIVES: Correlation between health locus of control and illness acceptance in patients with Graves-Basedow and Hashimoto diseases as well as correlation between health locus of control, illness acceptance, sex, and age. PATIENTS AND METHODS: THREE METHODS WERE APPLIED: Multidimensional Health Locus of Control Scale by K...
2012: International Journal of Endocrinology and Metabolism
Cristiano Carlone, Liliana Todini, Isabella Marini, Michele Majorana, Sara Casciato, Anna Teresa Giallonardo, Mauro Pallagrosi, Massimo Salviati, Massimo Biondi
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also known as Hashimoto encephalopathy, represents a rare disorder of presumed autoimmune origins that can be diagnosed when a protean variety of psychiatric symptoms are present in association with elevated titers of anti-thyroid antibodies. Symptoms can have a rapid and complete remission with corticosteroid treatment. A 19-year-old girl, with clinical history of Basedow-Graves disease, has been admitted to our department after presenting acute psychiatric symptomatology...
March 2013: Rivista di Psichiatria
Jorge Alberto Barragán-Garfias, Arturo Zárate
The main physiological function of the immune system consists in the defense against infectious micro-organisms. Sometimes there is a loss of immunological tolerance with the consequence of ignorance of self-antibodies. Some thyroid diseases are related to autoimmune diseases associated with the most common exocrine glands between them. There are also the autoimmune thyroid organ specific diseases, such as Graves-Basedow and the Hashimoto thyroiditis. It has been shown that there is a higher prevalence of autoimmune thyroid diseases in patients with connective tissue diseases (systemic autoimmune) such as Sjögren syndrome, rheumatoid arthritis, systemic lupus erithmatosis and systemic myopathic diseases...
March 2013: Revista Médica del Instituto Mexicano del Seguro Social
Omer Faruk Ozkan, Mehmet Asık, Huseyin Toman, Faruk Ozkul, Oztekin Cıkman, Muammer Karaayvaz
The thyroid is a vascular endocrine gland with two lateral lobes connected by a narrow, median isthmus. Although a wide range of congenital anomalies of the thyroid gland has been reported in the literature, agenesis of the thyroid isthmus is a very rare congenital anomaly. Thyroid isthmus agenesis does not manifest clinical symptoms, and it can be confused with other thyroid pathologies. We describe a patient with no isthmus of the thyroid, associated with Graves-Basedow disease. Thyroid isthmus agenesis should be kept in mind in order for surgical procedures involving thyroid pathologies to be carried out safely...
2013: Case Reports in Surgery
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