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https://www.readbyqxmd.com/read/27114794/the-effect-of-progesterone-treatment-after-ovarian-induction-on-endometrial-vegf-gene-expression-and-its-receptors-in-mice-at-pre-implantation-time
#1
Mandana Beigi Boroujeni, Nasim Beigi Boroujeni, Mohammadreza Gholami
OBJECTIVES: Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. MATERIAL AND METHODS: Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimulation]. Uterine horn samples removed at pre-implantation time in each group...
March 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/26887773/-response-of-potassium-channels-to-estrogen-and-progesterone-in-the-uterine-smooth-muscle-cells-of-adenomyosis-in-vitro
#2
Jinghua Shi, Li Jin, Jinhua Leng, Jinghe Lang
OBJECTIVE: To investigate the expression of potassium channels and the influence of estrogen and progesterone on the cultured uterine smooth muscle cells (USMC) of adenomyosis in vitro. METHODS: There were 22 cases of adenomyosis hysterectomy in the adenomyosis group and 12 patients with cervical intraepithelial neoplasia III removal of the uterus in the control group. USMC were separated and cultured in vitro, incubated with different concentrations of estrogen and progesterone...
November 2015: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26793616/immunohistochemical-profile-of-uterine-leiomyoma-with-bizarre-nuclei-comparison-with-conventional-leiomyoma-smooth-muscle-tumors-of-uncertain-malignant-potential-and-leiomyosarcoma
#3
Ali Dastranj Tabrizi, Morteza Ghojazadeh, Hanieh Thagizadeh Anvar, Amir Vahedi, Siamak Naji, Elmira Mostafidi, Siamak Berenjian
PURPOSE: To assess the immunohistochemical profile of the atypical nuclei in leiomyoma with bizarre nuclei and compare with benign and malignant counterparts. METHODS: 26 cases of uterine smooth muscle tumors including 12 leiomyosarcoma(LMS), 10 leiomyoma with bizarre nuclei (LBN) and 4 smooth muscle tumor with uncertain malignant potential (STUMP) were selected using whole tissue sections for this study and analysis. Six cases of ordinary leiomyoma were included as benign control group...
December 2015: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/24879526/nipple-discharge-of-ca15-3-ca125-cea-and-tsgf-as-a-new-biomarker-panel-for-breast-cancer
#4
Gangping Wang, Yan Qin, Junxi Zhang, Jinhui Zhao, Yun'ai Liang, Zuofeng Zhang, Meihua Qin, Yanqing Sun
Breast cancer is the second leading cause of cancer death in women. Serum biomarkers such as cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), and carcinoembryonic antigen (CEA) can be used as diagnostic and prognostic factors and can also provide valuable information during follow-up. However, serum protein biomarkers show limited diagnostic sensitivity and specificity in stand-alone assays because their levels reflect tumor burden. To validate whether biomarkers in nipple discharge may serve as novel biomarkers for breast cancer, we composed a panel of potential cancer biomarkers, including CA15-3, CA125, CEA, and malignant tumor-specific growth factor (TSGF), and evaluated their expression in both serum and nipple discharge in order to explore the expression and significance of estrogen receptor (ER), progestrone receptor (PR), epidermal growth factor receptor type 2 (HER2/neu), CA15-3, CA125, CEA, and TSGF expression for their combined predictive value for breast cancer and in judging the prognosis of breast cancer...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24762589/clinical-implications-and-prognostic-value-of-single-and-combined-biomarkers-in-endometrial-carcinoma
#5
Mingzhu Li, Lijun Zhao, Danhua Shen, Xiaoping Li, Jianliu Wang, Lihui Wei
BACKGROUND: Endometrial carcinoma is one of the most common gynecological cancers and the incidence has been increasing. This study was to identify the relationship of estrogen receptor (ER), progestrone receptor (PR), P53 protein, Ki-67 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) with endometrial carcinoma, the assessment of these biomarkers and their association with clinicopathological parameters was performed. METHODS: A total of 198 cases of primary endometrial carcinoma were investigated for ER, PR, Ki-67, P53, and PTEN antigens by immunohistochemical methods...
2014: Chinese Medical Journal
https://www.readbyqxmd.com/read/24693371/the-effects-of-progesterone-therapy-on-the-gestation-length-and-reduction-of-neonatal-complications-in-patients-who-had-received-tocolytic-therapy-for-acute-phase-of-preterm-labor
#6
Marzie Lotfalizadeh, Nayereh Ghomian, Amirreza Reyhani
BACKGROUND: While tocolytic therapy can halt the process of delivery, some patients return before the 37th week of pregnancy with recurrence of preterm labor signs. OBJECTIVES: This study was designed to evaluate the efficacy of progesterone in the prolonging of gestation and reduction of neonatal complications. MATERIAL AND METHODS: In a clinical trial in 2010, 110 singleton pregnant women admitted at Imam Reza Hospital, Mashhad, Iran, with the diagnosis of preterm labor were divided into three groups: 400 mg/d vaginal progesterone suppositories; 250 mg/w 17-alpha-hydroxyl-progestrone-caproate; and a control group with no additional treatment...
October 2013: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/24639698/efficacy-of-17%C3%AE-hydroxy-progestrone-on-decreasing-preterm-labor-in-art-pregnancies-a-randomized-clinical-trial
#7
Abbas Aflatoonian, Hoora Amouzegar, Razieh Dehghani Firouzabadi
BACKGROUND: Preterm labor (PTL) is one of the most important causes in neonatal mortality and morbidity. Late preterm labor (34-36w) includes 75% of such birth. Assisted reproductive technology (ART) pregnant women are at increased risk of PTL. OBJECTIVE: The study has been undertaken to determine whether beginning and continuing 17-α hydroxy progesterone caproate can reduce risk of PTL or change neonatal mortality. MATERIALS AND METHODS: In a double-blind clinical randomized control trial, 106 women were treated by ART technique for their infertility and in gestational age at 16 weeks entered in our study...
October 2013: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/23898489/important-role-of-the-c-terminal-region-of-pig-aldo-keto-reductase-family-1-member-c1-in-the-nadph-dependent-reduction-of-steroid-hormones
#8
Seul Gi Kwon, Woo Young Bang, Jin Young Jeong, Hwak Rae Cho, Da Hye Park, Jung Hye Hwang, Tae Wan Kim, Moon-Suck Ko, In-Cheol Cho, Young Kuk Joo, Mi-Ae Jeong, Sam Woong Kim, Chul Wook Kim
The NADPH-dependent reduction activities of two paralogous pig AKR1C1s with and without 19 additional amino acid residues in C-terminus were evaluated against steroid hormones including 5alpha-dihydrotestosterone, testosterone, progesterone, androstenedione and 5alpha-androstane-3.17-dione, which act as substrates of the AKR1C1S. Among the hormones, the AKR1C1s exhibited the highest activity against 5alpha-dihydrotestosterone and the lowest activity against testosterone and progesterone. Furthermore, the AKR1C1s showed the largest differential activities against; 5alpha-dihydrotestosterone, but no such change of activities was found against progestrone and testosterone...
June 2013: Indian Journal of Biochemistry & Biophysics
https://www.readbyqxmd.com/read/23886210/expression-and-significance-of-er-pr-vegf-ca15-3-ca125-and-cea-in-judging-the-prognosis-of-breast-cancer
#9
COMPARATIVE STUDY
Su-Jie Zhang, Yi Hu, Hai-Li Qian, Shun-Chang Jiao, Zhe-Feng Liu, Hai-Tao Tao, Lu Han
OBJECTIVE: To explore the expression and significance of estrogen receptor (ER), progestrone receptor (PR), vascular endothelial growth factor (VEGF), CA15-3, CA125 and carcinoma embryonic antigen (CEA) expression in judging the prognosis of breast cancer. MATERIALS AND METHODS: Sixty-five patients with breast cancer undergoing operations in the general surgery department were considered as the observation group, and 50 healthy outpatients of our hospital as the control group...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23739254/adenomatoid-odontogenic-tumour-mimicking-a-periapical-cyst-in-pregnant-woman
#10
Neha Bhandari, Mohit Kothari
Adenomatoid odontogenic tumours (AOT) are uncommon odontogenic lesions characterized histologi-cally by duct-like structures derived from the epithelial component of the lesion and can be distinctly classified into follicular, extrafollicular and extraosseous variants (Neville BW, Damm DD, Allen CM, et al. Adenomatoid Odontogenic Tumor. A Text Book for Oral and Maxillofacial Pathology, 2(nd) edition, 621-3). Most of these tumours develop in the second or third decade of life and have a distinct predilection for women...
June 2010: Singapore Dental Journal
https://www.readbyqxmd.com/read/23056821/a-case-of-atypical-mccune-albright-syndrome-with-vaginal-bleeding
#11
Noushin Rostampour, Mahin Hashemipour, Roya Kelishadi, Silva Hovsepian, Ali Hekmatnia
BACKGROUND: McCune-Albright syndrome (MAS) is a rare non-inherited disorder characterized by the clinical triad of precocious puberty, cafe-au-lait skin lesions, and fibrous dysplasia of bone. CASE PRESENTATION: We report a girl with MAS, presenting initially with vaginal bleeding at the age of 17 months. Ultrasonography revealed unilateral ovarian cysts and ureteral and ovarian enlargement. Considering the clinical and paraclinical findings, the patient diagnosed as a case of gonadotropin-independent precocious puberty was treated with medroxy-progestrone acetate (MPA) for three months...
September 2011: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/22797202/pattern-of-oestrogen-progesterone-and-her2neu-receptors-expression-in-a-heterogeneous-carcinoma-of-the-breast-in-a-lactating-woman
#12
Mohammed Naim, Amit Kumar, Kavita Gaur, Vanesa T John
Oestrogen-progestrone-Her2neu receptor status was studied in various loci/foci of heterogeneous carcinoma of the breast and its metastatic secretory component in the lymph node in a lactating woman. All the carcinoma variants were negative for the trio markers except tumour components evolved to secretory or lactating carcinoma, which showed focal positivity. Findings showed that oestrogenic receptors, progesterone receptors and Her2neu negative primitive carcinoma in a heterogenous breast cancer may evolve into oestrogen receptor, progesterone receptor and Her2neu positive secretory/lactating carcinoma alongside other receptor negative carcinoma variants...
2010: BMJ Case Reports
https://www.readbyqxmd.com/read/22227546/expression-of-oestrogen-progestrone-and-androgen-receptors-in-salivary-gland-tumours-a-review-of-literature
#13
REVIEW
B Tarakji, O Kujan
Hormone therapy is highly recommended on patients with breast cancer who show positive nuclear staining of the cancer cells. It is not known however whether salivary gland tumours can respond to hormone therapy. Twenty eight studies undertaken between 1980 to 2009 involving different types of salivary gland cancers were evaluated and taken into consideration the type of used antibody and the criteria to assess the intensity staining. This review has shown that estrogen progesterone and androgen receptors were detected in few cases of salivary gland tumours...
January 2012: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/22226178/pattern-of-distant-recurrence-according-to-the-molecular-subtypes-in-korean-women-with-breast-cancer
#14
Hyung Seok Park, Shinhyuk Kim, Kiho Kim, Ho Yoo, Byung Joo Chae, Ja Seong Bae, Byung Joo Song, Sang Seol Jung
BACKGROUND: Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. METHODS: In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated...
2012: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/22059352/tumor-derived-ccl-2-and-cxcl-8-as-possible-prognostic-markers-of-breast-cancer-correlation-with-estrogen-and-progestrone-receptor-phenotyping
#15
H M Ghoneim, Sara Maher, Asmaa Abdel-Aty, A Saad, A Kazem, S R Demian
Prognosis of breast cancer is believed to be a multifactorial process best achieved by complex factors including host and tumor-derived biomarkers together with traditional clinicopathological parameters and tumor histologic markers. The present study aimed at evaluating the prognostic significance of chemokine ligand-2 (CCL-2) and interleukin-8 (CXCL-8) expression in extracts of breast carcinomas through correlation with clinicopathological aspects as well as estrogen receptor (ER) and progesterone receptor (PR) phenotyping...
2009: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/21887718/4e-bp1-degradation-and-eif4e-truncation-occur-spatially-distinctly-in-the-porcine-uterine-epithelia-and-are-features-of-noninvasive-implantation-in-the-pig
#16
Karin Wollenhaupt, Kati Reinke, Klaus-Peter Brüssow, Wilhelm Kanitz, Wolfgang Tomek
The implantation of the blastocyst into the endometrium is an indispensable premise for successful embryonic development. This process is regulated by maternal and embryonic signals that influence gene expression at the translational level, among other processes. Recently, we have shown that proteolytical cleavage of the prototypical 25-kDa, mRNA cap-binding protein eIF4E produces a stable variant with a molecular mass of approximately 23 kDa exclusively in the porcine endometrium during implantation. This is accompanied by dephosphorylation and reduction of the abundant repressor 4E-BP1...
December 2011: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/21137648/expression-of-progestrone-receptor-and-proliferative-marker-ki-67-in-various-grades-of-meningioma
#17
Nasrin Shayanfar, Masoud Mashayekh, Masoud Mohammadpour
Meningiomas are slow-growing neoplasms which recur locally, their morphologic grading is simple but do not always correlate with patient outcome. The aim of present study is to evaluate the status of progesterone receptor (PR) and proliferation marker Ki67 in various grades of meningioma in a group of Iranian patients. 78 cases of meningioma were selected from the file of a hospital university. All archival H&E stained sections were reviewed and regraded according to WHO criteria. Immunohistochemical analysis for PR and Ki67 was performed on formalin-fixed, paraffin-embedded samples...
May 2010: Acta Medica Iranica
https://www.readbyqxmd.com/read/20019776/-expression-and-function-of-cyclooxygenase-2-in-endometrial-carcinoma
#18
Jun-ya Chen, Qin-ping Liao
OBJECTIVE: To evaluate the cyclooxygenase-2(COX-2) expression at mRNA and protein levels, as well as its clinical significance, and to study the correlation of COX-2 with angiogenesis, apoptosis and estrogen or progestron receptors. METHODS: Forty-one samples of normal endometrium tissues and 52 ones of endometrial carcinomas(EC) were collected, together with their corresponding clinical information. RT-PCR was adopted to determine the expression of COX-2 mRNA. Immunohistochemical staining was engaged to evaluate the protein expression of COX-2, VEGF, Bcl-2 and the MVD marked by CD105...
December 18, 2009: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/19999724/in-vitro-binding-of-progesterone-to-receptors-in-the-human-endometrium-and-the-myometrium
#19
U Verma, K R Laumas
High affinity, low capacity progesterone binding receptors have been identified in the cytosol fractions of the human endometrium and the myometrium. The endometrial and the myometrial progesterone binding proteins had sedimentation coefficients of 4.5 S and 4.1 S, respectively. Analysis of the bound steroids revealed that, along with progesterone, small amounts of its metabolites (20alpha-hydroxy-4-pregnene-3-one, 5alpha-pregnane-3,20-dione, 5alpha-pregnane-20alpha-ol-3-one) were also bound to the receptor proteins...
August 30, 1973: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/19292937/the-role-of-her2-in-metastatic-breast-cancer-treated-with-a-combination-of-taxanes-and-cisplatin
#20
Hung-Chih Hsu, Hsien-Kun Chang, Yung-Chang Lin, Sheu Hseu, Jen-Shi Chen, Tsai-Shen Yang, Hung-Ming Wang, Wen-Chi Shen
BACKGROUND: A combination of taxanes and cisplatin have shown modest activity as second-line chemotherapy in breast cancer patients who have been exposed to anthracyclines. The purpose of this study was to retrospectively assess whether HER2 is associated with clinical sensitivity or with prognostic significance in breast cancer patient groups who had received chemotherapy with taxanes and cisplatin. METHODS: Patients were treated either with docetaxel 60 mg/m square or paclitaxel 175 mg/m square in combination with cisplatin 50 mg/m/every 3 weeks...
January 2009: Chang Gung Medical Journal
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