keyword
https://read.qxmd.com/read/38532784/the-s1-subunits-of-sars-cov-2-variants-differentially-trigger-the-il-6-signaling-pathway-in-human-brain-endothelial-cells-and-downstream-impact-on-microglia-activation
#1
JOURNAL ARTICLE
Michael Stangis, Daniel Adesse, Bhavya Sharma, Eduardo Castro, Kush Kumar, Neil Kumar, Masha Minevich, Michal Toborek
OBJECTIVES: Cerebrovascular complications are prevalent in COVID-19 infection and post-COVID conditions; therefore, interactions of SARS-CoV-2 with cerebral microvascular cells became an emerging concern. METHODS: We examined the inflammatory responses of human brain microvascular endothelial cells (HBMEC), the main structural element of the blood-brain barrier (BBB), following exposure to the S1 subunit of the spike protein of different SARS-CoV-2 variants. Specifically, we used the S1 subunit derived from the D614 variant of SARS-CoV-2, which started widely circulating in March of 2020, and from the Delta variant, which started widely circulating in early 2021...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532430/needle%C3%A2-based-gastrocnemius-lengthening-a-novel-ultrasound%C3%A2-guided-noninvasive-technique-part-ii-clinical-results
#2
JOURNAL ARTICLE
A Iborra, M Villanueva, H Fahandezh-Saddi Díaz
BACKGROUND: Isolated gastrocnemius contracture has been associated with more than 30 lower limb disorders, including plantar heel pain/plantar fasciitis, Achilles tendinosis, equinus foot, adult flatfoot, and metatarsalgia. Although many techniques are available for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques usually require epidural or general anesthesia, exsanguination of the lower extremities and stitches and can damage the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
March 26, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38514157/maximum-outcome-with-minimal-resources-report-of-a-multiligamentous-knee-injury-managed-with-modified-confluent-tunnel-technique
#3
JOURNAL ARTICLE
Girinivasan Chellamuthu, Nitesh Kumar Rathi, Munis Ashraf, Benjamin Vinodh
Multiligamentous knee injuries (MLKIs) are rare and challenging to manage in many aspects. The injury requires prompt diagnosis, reconstruction of multiple ligaments, and management of associated neurovascular injuries. Another important aspect that surgeons should consider is resource availability. Successful management of a case of MLKI using the cost-effective 'modified confluent tunnel technique' is described in this case report. We used confluent tunnels for intra- and extra-articular ligament reconstructions at the femoral side...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#4
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38510591/management-of-patients-with-a-neurovascular-conflict-involving-the-optic-nerve-and-a-non-diseased-intracranial-artery-three-cases
#5
H Schenck, M Müther, E Maragno, M Holling, M Cornelissen, R Haeren
INTRODUCTION: Determining whether a neurovascular conflict (NVC) involving the anterior visual pathway (AVP) and a non-diseased intracranial artery is amenable for microvascular decompression is challenging. Moreover, it is unclear whether microvascular decompression of the optic nerve is an effective therapy. RESEARCH QUESTION: What are the outcomes of different treatment strategies for NVCs involving the AVP and a non-diseased intracranial artery? MATERIAL AND METHODS: Data on patients with symptomatic NVCs involving the AVP and a non-diseased intracranial artery was collected and included treatment and outcome parameters...
2024: Brain Spine
https://read.qxmd.com/read/38506687/balloon-pressure-and-clinical-effectiveness-of-percutaneous-microballoon-compression-in-the-treatment-of-primary-trigeminal-neuralgia
#6
JOURNAL ARTICLE
Yingqian Peng, Cong Zou, Yonglin Li, Qing Li, Hui Long, Wuzhou Yang, Zhenping Xiao, Liping Jiang, Wei Gao, Yunwu He
BACKGROUND: Primary trigeminal neuralgia (PTN) is a type of chronic neuropathic pain disorder caused by neurovascular compression. Percutaneous balloon compression (PBC) is a widely used method for the treatment of PTN. OBJECTIVES: To examine the correlation of balloon pressure (BP) during percutaneous microballoon compression (PBC) with postoperative pain relief and complications in the treatment of primary trigeminal neuralgia (PTN). STUDY DESIGN: Forty-five patients diagnosed with PTN and treated with PBC were recruited...
March 2024: Pain Physician
https://read.qxmd.com/read/38503162/a-giant-multi-compartment-lipoma-of-the-hand-causing-median-nerve-compression-a-case-report-and-review-of-literature
#7
Deshan Gomez, Dishan Samarathunga, Dammika Dissanayake, Gayan Ekanayake
INTRODUCTION & IMPORTANCE: Lipomas are slow growing benign soft tissue tumors that arise from mesenchymal preadipocytes. Histologically they are composed of mature adipocytes. They typically have a shawl like distribution in the body, anywhere from the subcutaneous space to bone, but are seen only rarely in the hand. When >5 cm, they are referred to as 'giant lipoma' and can be symptomatic due to neurovascular compression and impaired hand function. CASE PRESENTATION: A 51-year-old forensic analyst presented with a progressively enlarging lump over the thenar eminence and palm of his dominant right hand for 2 years duration...
March 15, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38499881/basilar-artery-perforator-aneurysms-a-comparison-with-non-perforator-saccular-aneurysms
#8
JOURNAL ARTICLE
Antony Kaldas, Ardalan Zolnourian, Frederick Ewbank, Ronneil Digpal, Ana Narata, Adam Ditchfield, Jason Macdonald, Diederik Bulters
BACKGROUND: Basilar artery perforator aneurysms (BAPAs) are rare. There is no systematic description of their presentation, imaging, natural history and outcomes and how these compare to conventional non-perforator aneurysms. Thus, the authors in this study aimed to compare BAPAs to non-perforator aneurysms. METHODS: Cases were identified from a prospective neurovascular database, notes and imaging retrospectively reviewed and compared to a consecutive series of patients with non-perforator aneurysms...
March 19, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38495306/neurovascular-coupling-impairment-as-a-mechanism-for-cognitive-deficits-in-covid-19
#9
REVIEW
Cameron D Owens, Camila Bonin Pinto, Sam Detwiler, Lauren Olay, Ana Clara da C Pinaffi-Langley, Peter Mukli, Anna Peterfi, Zsofia Szarvas, Judith A James, Veronica Galvan, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari, Angelia C Kirkpatrick, Calin I Prodan, Andriy Yabluchanskiy
Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular structures and physiologic processes within the neurovascular unit and contribute to cognitive dysfunction. COVID-19 has posed significant complications during acute and convalescent stages in multiple organ systems, including the brain. Cognitive impairment is a prevalent complication in COVID-19 patients, irrespective of severity of acute SARS-CoV-2 infection...
2024: Brain communications
https://read.qxmd.com/read/38493417/a-reappraisal-of-the-deep-uterine-vein-a-multimodal-exploration-with-implications-for-pelvic-surgery
#10
JOURNAL ARTICLE
Fabien Robin, Léa Roux, Myra A Zaheer, Laurent Sulpice, Ludivine Dion, Vincent Lavoue, Julien Landreau, Xavier Morandi, Krystel Nyangoh Timoh
PURPOSE: Pelvic gynecological surgeries, whether for malignant or benign conditions, frequently result in functional complications due to injuries to the autonomic nervous system. Recognizing the deep uterine vein (DUV) as an essential anatomical reference can aid in preserving these structures. Despite its significance, the DUV is infrequently studied and lacks comprehensive documentation in Terminologia Anatomica. This research endeavors to elucidate a detailed characterization of the DUV...
March 17, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38491850/mammalian-diaphanous1-signalling-in-neurovascular-complications-of-diabetes
#11
JOURNAL ARTICLE
Julia Jarosławska, Bernard Kordas, Tadeusz Miłowski, Judyta K Juranek
Over the past few decades, diabetes gradually has become one of the top non-communicable disorders, affecting 476.0 million in 2017 and is predicted to reach 570.9 million people in 2025. It is estimated that 70 to 100% of all diabetic patients will develop some if not all, diabetic complications over the course of the disease. Despite different symptoms, mechanisms underlying the development of diabetic complications are similar, likely stemming from deficits in both neuronal and vascular components supplying hyperglycaemia-susceptible tissues and organs...
March 16, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38491207/extraperitoneal-robot-assisted-laparoscopic-prostatectomy-with-versius-system-single-centre-experience
#12
JOURNAL ARTICLE
F Dibitetto, C Fede Spicchiale, R Castellucci, S Sansalone, A Akhundov, L Defidio, M De Dominicis
INTRODUCTION: Versius Surgical System (CMR Surgical, Cambridge, UK) is a novel tele-operated robotic surgical system designed to assist surgeons for minimally invasive surgery which is gaining momentum in the world of robotic surgery. We describe our single centre experience with Versius and report the advantages and challenges posed by this new robotic system in a series of 53 extraperitoneal robotic assisted laparoscopic prostatectomies (eRALP) for prostate cancer (PCa). MATERIALS AND METHODS: Data of 53 eRALP performed with Versius in our centre were collected and analysed, Descriptive statistics were used to report our results...
March 15, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38490975/modified-tap-drilling-technique-for-mid-cervical-pedicle-screw-placement-a-case-series-of-473-consecutive-screws
#13
JOURNAL ARTICLE
Hasan Kâmil Sucu, İsmail Ertan Sevin, Gökhan Gürkan
STUDY DESIGN: Retrospective cohort study. OBJECTION: To report our modified tap-drilling technique for mid-cervical pedicle screw placement and to evaluate its safety and accuracy. SUMMARY OF BACKGROUND DATA: Cervical pedicle screw fixation, which provides a strong stabilization, has been a major concern due to the potential risks to neurovascular structures despite its increasing use. Several insertion techniques have been described so far to improve the cervical pedicle screw placement accuracy...
March 12, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38490802/how-surgeons-think-to-avoid-error-a-case-study-of-the-neurovascular-bundle-sparing-during-a-robotic-prostatectomy
#14
JOURNAL ARTICLE
Avril Lusty, Janet Alexanian, Simon Kitto, Tim Wood, Luke T Lavallée, Chris Morash, Ilias Cagiannos, Rodney H Breau, Isabelle Raîche
OBJECTIVE: To illustrate how experts efficiently navigate a "slowing down moment" to obtain optimal surgical outcomes using the neurovascular bundle sparing during a robotic prostatectomy as a case study. DESIGN: A series of semistructured interviews with four expert uro-oncologists were completed using a cognitive task analysis methodology. Cognitive task analysis, CTA, refers to the interview and extraction of a general body of knowledge. Each interview participant completed four 1 to 2-hour semistructured CTA interviews...
April 2024: Journal of Surgical Education
https://read.qxmd.com/read/38487394/bilateral-carotid-body-tumours-a-case-report-from-surgeon-s-perspective
#15
Kishen Raj Chandra Sakaran, Toot Tiew, Khidhir Kamil, Hisham Arshad Habeebullah Khan, Mohamad Azim Idris, Lenny Suryani Safri
Carotid body tumour (CBT) is the most common paraganglioma of the head and neck and may compromise neurovascular structures such as carotid vessels, and cranial nerves. Intracranial extension from the mass is possible if left untreated. The main treatment for CBT is surgical resection albeit extremely challenging due to tumour hypervascularity and its relationship to the carotid artery. A bilateral CBT, however, is a rare occurrence. Herein, we present a case of a man who presented to us with bilateral painless and palpable neck mass...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38485848/pretreatment-with-a-dual-antiplatelet-and-anticoagulant-apac-reduces-ischemia-reperfusion-injury-in-a-mouse-model-of-temporary-middle-cerebral-artery-occlusion-implications-for-neurovascular-procedures
#16
JOURNAL ARTICLE
Frederik Denorme, Juhana Frösen, Annukka Jouppila, Antti Lindgren, Julio C Resendiz-Nieves, Hannu Manninen, Simon F De Meyer, Riitta Lassila
BACKGROUND: Several neurovascular procedures require temporary occlusion of cerebral arteries, leading to ischemia of unpredictable length, occasionally causing brain infarction. Experimental models of cerebral ischemia-reperfusion injury have established that platelet adhesion and coagulation play detrimental roles in reperfusion injury following transient cerebral ischemia. Therefore, in a model of cerebral ischemia-reperfusion injury (IRI), we investigated the therapeutic potential of a dual antiplatelet and anticoagulant (APAC) heparin proteoglycan mimetic which is able to bind to vascular injury sites...
March 15, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38484970/infrasellar-nasopharyngeal-craniopharyngiomas-an-individual-participant-data-meta-analysis-and-review-of-the-literature
#17
REVIEW
Krisna S Maddy, Evan Luther, Ian A Ramsay, Katherine Berry, Lekhaj Daggubati, Alexis Morell, Martin Merenzon, Daniel G Eichberg, Ashish Shah, Ricardo Komotar, Michael Ivan
OBJECTIVE: Craniopharyngiomas are benign tumors of the anterior skull base arising from epithelial remnants of Rathke's pouch. They mainly occur in the suprasellar space, can be incredibly debilitating, and remain difficult to resect as they frequently involve critical neurovascular structures. Although it is embryologically possible for craniopharyngiomas to arise extracranially along the entire migrational path of Rathke's pouch, these remain exceedingly rare, especially among adults, and can be mistaken for nasopharyngeal cancer...
March 12, 2024: World Neurosurgery
https://read.qxmd.com/read/38482632/real-world-experience-with-11c-methionine-pet-in-the-management-of-acromegaly
#18
JOURNAL ARTICLE
Linus Haberbosch, James MacFarlane, Olympia Koulouri, Daniel Gillett, Andrew S Powlson, Sue Oddy, David J Halsall, Kevin A Huynh, Jonathan Jones, Heok K Cheow, Joachim Spranger, Knut Mai, Christian Strasburger, Richard J Mannion, Mark Gurnell
BACKGROUND: L-[methyl-11C]-methionine-positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumours. Met-PET can identify residual or occult disease and make definitive therapies accessible to a subgroup of patients who would otherwise require lifelong medical therapy. However, existing data on its use are still limited to small case series. Here, we report the largest single centre experience (N=61) in acromegaly...
March 14, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38482365/infratemporal-abscess-a-rare-complication-of-a-common-procedure
#19
Rajesh Kotagiri, Matthew L Repp, Michael H Kim, Faissal Stipho
The infratemporal fossa (ITF) is an anatomically complex cavity that houses a variety of muscular and neurovascular structures at the base of the skull. Infections involving the ITF, though uncommon, can be fatal due to the difficulties of accessing this anatomical space and its proclivity to evolve into a cavernous venous thrombosis (CVT). As a result, a multi-disciplinary approach involving several surgical and medical subspecialists is often warranted. We present a case of an infratemporal fossa abscess (IFA) after wisdom teeth extraction with a very complicated clinical course and a distinct microbiologic profile...
2024: Access microbiology
https://read.qxmd.com/read/38481580/isolated-subtalar-dislocations-insights-from-a-case-study-and-literature-review
#20
REVIEW
Alzahid Abdullah, Alghamdi Mohannad, Alkhadra Faisal, Almulihi Qasem, Assiri Mohammed, Almulhim Mohammed, Alhawas Abdulaziz
BACKGROUND: Isolated subtalar joint dislocations without associated fractures are rare in the medical literature. They occur when the talus bone remains in place while the calcaneus and navicular bones shift out of place. These dislocations account for about 15% of talus bone injuries and 1 to 2% of all joint dislocations. They are more common in young men following inversion trauma. OBJECTIVE: This study aims to improve the understanding of diagnosis, treatment, and management of these rare injuries for better patient care...
2024: Medical Archives
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