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https://www.readbyqxmd.com/read/28633346/tetramethylpyrazine-reverses-intracerebroventricular-streptozotocin-induced-memory-deficits-by-inhibiting-gsk-3%C3%AE
#1
Fen Lu, Xu Li, Wei Li, Ke Wei, Yong Yao, Qianlin Zhang, Xinliang Liang, Jiewen Zhang
Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer's disease (AD), which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine (TMP) is one of the major bioactive compounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegenerative diseases, including Parkinson's disease...
June 15, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28626630/arthroscopic-removal-of-proximal-humerus-plates-in-chronic-post-traumatic-shoulder-stiffness
#2
Deepak N Bhatia
Proximal humerus fracture fixation may be complicated by persistent postsurgical stiffness or implant-related problems. Arthroscopic plate removal is a cosmetic and functionally beneficial procedure; however, the procedure is technically difficult in the presence of severe subdeltoid scarring. The technique described here shows an arthroscopic subdeltoid adhesiolysis and proximal humerus plate removal using systematic access to 5 regions of screw positions on the plate. After initial glenohumeral adhesiolysis, a thorough subacromial and subdeltoid bursectomy is performed...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28619495/results-of-atypical-hemifacial-spasm-with-microvascular-decompression-14-cases-reported-and-lectures-reviewed
#3
Hua Zhao, Xin Zhang, Ying Zhang, Yin-da Tang, Jin Zhu, Xu-Hui Wang, Ting-Ting Ying, Shi-Ting Li
OBJECTIVE: There were few studies reporting atypical hemifacial spasm(AHFS) and the mechanism of AHFS is still unclear. The purpose of this article was to study the etiology, prognosis and treatment of atypical hemifacial spasm. METHODS: We retrospectively analyzed the clinical data for 14 consecutive patients that underwent microvascular decompression(MVD) for AHFS from January 2014 to December 2015. The clinical feature, outcome and complications were observed...
June 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28607785/pseudoaneurysm-of-the-anterior-tibial-artery-following-ankle-arthroscopy-in-a-soccer-player
#4
Ichiro Tonogai, Tetsuya Matsuura, Toshiyuki Iwame, Keizo Wada, Tomoya Takasago, Tomohiro Goto, Daisuke Hamada, Yohei Kawatani, Eiki Fujimoto, Tetsuya Kitagawa, Shyoichiro Takao, Seiji Iwamoto, Moriaki Yamanaka, Masafumi Harada, Koichi Sairyo
Ankle arthroscopy carries a lower risk of vascular complications when standard anterolateral and anteromedial portals are used. However, the thickness of the fat pad at the anterior ankle affords little protection for the thin-walled anterior tibial artery, rendering it susceptible to indirect damage during procedures performed on the anterior ankle joint. To our knowledge, only 11 cases of pseudoaneurysm involving the anterior tibial artery after ankle arthroscopy have been described in the literature. Here we reported a rare case of a 19-year-old soccer player who presented with pseudoaneurysm of the anterior tibial artery following ankle arthroscopy using an ankle distraction method and underwent anastomosis for the anterior tibial artery injury...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28589499/results-from-the-surgical-resection-of-severe-heterotopic-ossification-of-the-hip-a-case-series-of-26-patients
#5
George A Macheras, Panagiotis Lepetsos, Andreas Leonidou, Panagiotis P Anastasopoulos, Spyridon P Galanakos, Eleftherios Tsiridis
INTRODUCTION: Surgical resection of heterotopic ossification (HO) around the hip joint is often challenging. The aim of this study is to evaluate the clinical and radiological outcomes following surgical resection of Brooker's type III and IV HO of the hip. METHODS: We retrospectively reviewed clinical and radiological data, between November 2006 and January 2013, of all patients who underwent surgical resection of severe HO of the hip. Brooker's grading, range of motion and the Harris Hip Score before and after surgery were recorded in all cases...
June 6, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28589159/demographics-and-injuries-associated-with-knee-dislocation-a-prospective-review-of-303-patients
#6
Gilbert Moatshe, Grant J Dornan, Sverre Løken, Tom C Ludvigsen, Robert F LaPrade, Lars Engebretsen
BACKGROUND: Information on the incidence, injury mechanisms, ligament injury patterns, and associated injuries of knee dislocations is lacking in the literature. There is a need to characterize ligament injury patterns and associated injuries in knee dislocations to avoid missing common associated diagnoses and to plan surgical treatment. PURPOSE: To evaluate patient demographics, ligament injury patterns and associated injury patterns, and associated injuries in patients with knee dislocation...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28584947/mechanical-recanalization-using-solitaire-ab-device-for-severe-thromboembolic-events-in-endovascular-treatment-of-intracranial-aneurysms
#7
Qiuji Shao, Liangfu Zhu, Tianxiao Li, Li Li, Yingkun He, Kaitao Chang, Xiaodong Liang
INTRODUCTION: Severe thromboembolism with complete occlusion of the proximal arteries during or after coil embolization can cause serious neurologic deficits. The study aimed to assess the effectiveness and safety of Solitaire AB device as a rescue therapy for severe thromboembolic complications in the endovascular treatment of intracranial aneurysms. MATERIALS AND METHODS: Between February 2013 and April 2016, 1047 intracranial aneurysms treated with endovascular procedures were retrospectively reviewed in our center...
June 5, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28580257/posterior-surgical-approach-to-the-knee
#8
Scott C Faucett, James Gannon, Jorge Chahla, Marcio B Ferrari, Robert F LaPrade
Posterior knee approaches are reliable techniques to address the treatment of various pathologies of the posterior region of the knee, including Baker cyst excision, tibial plateau fracture fixation, posterior cruciate ligament avulsions and inlay reconstructions, femoral condyle cartilage procedures, posterior meniscal repair and loose body removal among others. Surgery in the posterior knee region can be challenging because of the presence of neurovascular structures including the tibial nerve, popliteal artery and vein, and common peroneal nerve; thus, it is less commonly performed...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28574144/robot-assisted-nerve-sparing-radical-prostatectomy-using-near-infrared-fluorescence-technology-and-indocyanine-green-initial-experience
#9
Mario S Mangano, Alberto De Gobbi, Francesco Beniamin, Claudio Lamon, Matteo Ciaccia, Luigino Maccatrozzo
INTRODUCTION: Indocyanine green (ICG) is a fluorescent molecule that provokes detectable photon emission. The use of ICG with near-infrared (NIR) imaging system (Akorn, Lake Forest, IL) has been described during robotic partial nephrectomy (RAPN) as an adjunctive means of identifying renal artery and parenchymal perfusion.We propose the use of the ICG with NIR fluorescence during laparoscopic robot-assisted radical prostatectomy (RARP), to identify the benchmark artery improving the preservation of neurovascular bundle and to improve the visualization of the vascularization and then the hemostasis...
May 23, 2017: Urologia
https://www.readbyqxmd.com/read/28573513/knee-joint-preservation-surgery-in-osteosarcoma-using-tumour-bearing-bone-treated-with-liquid-nitrogen
#10
Takashi Higuchi, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Yu Aoki, Kensaku Abe, Yuta Taniguchi, Hiroyuki Tsuchiya
PURPOSE: To preserve the joint structure in order to maintain good limb function in patients with osteosarcoma, we perform epiphyseal or metaphyseal osteotomy and reconstruction using frozen autografts that contain a tumour treated with liquid nitrogen. There are two methods of using liquid nitrogen-treated autografts: the free-freezing method and the pedicle-freezing method. The purpose of this study was to evaluate the results of intentional joint-preserving reconstruction using the free-freezing method and the pedicle-freezing method in patients with osteosarcoma...
June 1, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28572033/blood-brain-barrier-disruption-in-diabetic-mice-is-linked-to-nrf2-signaling-deficits-role-of-abcb10
#11
Ravi K Sajja, Shikha Prasad, Suni Tang, Mohammad A Kaisar, Luca Cucullo
Blood-brain barrier (BBB) damage is a critical neurovascular complication of diabetes mellitus that adversely affects the CNS health and function. Previously, we showed the protective role of NF-E2 related factor-2 (Nrf2), a redox sensitive transcription factor, in regulation of BBB integrity. Given the pathogenic role of mitochondrial oxidative stress in diabetes-related microvascular complications, we focused on assessing: 1) the impact of diabetes on brain Nrf2 in correlation with BBB permeability and 2) Nrf2-dependent regulation of the mitochondrial transporter ABCB10, an essential player in mitochondrial function and redox balance at BBB endothelium...
May 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28555373/blood-brain-barrier-injury-in-diabetes-unrecognized-effects-on-brain-and-cognition
#12
REVIEW
Marina Bogush, Nathan A Heldt, Yuri Persidsky
Diabetes mellitus (DM) is a disorder due to the inability properly to metabolize glucose associated with dysregulation of metabolic pathways of lipids and proteins resulting in structural and functional changes of various organ systems. DM has detrimental effects on the vasculature, resulting in the development of various cardiovascular diseases and stemming from microvascular injury. The blood brain barrier (BBB) is a highly specialized structure protecting the unique microenvironment of the brain. Endothelial cells, connected by junctional complexes and expressing numerous transporters, constitute the main cell type in the BBB...
May 29, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28552441/success-rate-and-complications-associated-with-dental-implants-in-the-incisive-canal-region-a-systematic-review
#13
REVIEW
J S de Mello, F Faot, G Correa, O L Chagas Júnior
A systematic review was conducted to evaluate the success rate of dental implants placed in the incisive canal region and the complications related to this procedure. An electronic search was performed in the PubMed, Scopus, and Web of Science databases. Articles reporting the incisive canal deflation technique or neurovascular bundle lateralization technique, with or without concomitant dental implant installation and grafting procedures, were evaluated. Ten articles met the inclusion criteria; only one retrospective study and one longitudinal clinical trial were found...
May 25, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28540473/innovative-use-of-single-incision-internal-fixation-of-distal-clavicle-fractures-augmented-with-coracoclavicular-stabilisation
#14
Rajpal Nandra, Tomasz Kowalski, Socrates Kalogrianitis
INTRODUCTION: The management of displaced fractures of the distal clavicle remains controversial, particularly in younger patients where there is no consensus as to which surgical intervention is best. Each surgical method has unique surgical complications and rates of persistent pain and post-traumatic arthritis. We report an innovative surgical technique using a plate fixation augmented with minimally invasive tension slide coracoclavicular fixation using a cortical tenodesis button (8...
May 24, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28536819/a-clinical-review-of-11-cases-of-large-sized-well-differentiated-liposarcomas
#15
Camilla Arvinius, Elías Torrecilla, Joaquín Beano-Collado, Javier García-Coiradas, Roberto García-Maroto, María Puerto-Vázquez, Juan Luis Cebrián-Parra
Well-differentiated liposarcomas of the extremities are one of the most frequent types of malignant soft tissue tumors in adults. These tumors are typically locally aggressive and show a tendency to recurrence after surgical excision even though they do not metastasize and very rarely dedifferentiate. Its clinical presentation is generally a progressively growing mass causing aesthetic, functional, or compressive symptoms depending on the tumor's size and localization. Several authors recommend a wide excision with free margins in order to minimize the risk of recurrence, while others report good results and a low rate of recurrence with more conservative or even marginal excision thereby avoiding complications due to surgical site morbidity...
May 23, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28534175/-aseptic-loosening-of-total-ankle-replacement-two-stage-revision-with-bone-augmentation-of-osseous-defects-and-secondary-prosthesis-implantation
#16
A Barg, M Wiewiorski, V Valderrabano
OBJECTIVE: To remove loosened ankle prosthesis components, perform osseous defect augmentation, and reimplant definitive prosthesis components to preserve ankle range of motion. INDICATIONS: Aseptic loosening of the tibial and/or talar ankle prosthesis components with substantial bone defect. CONTRAINDICATIONS: General surgical/anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy, substantial nonreconstructable osseous defects with or without cysts on the tibial and/or talar side, noncompliance, primary total ankle replacement (TAR) using intramedullary fixation (stem fixation), severely reduced bone quality, insulin-dependent diabetes mellitus, smoking, unrealistic patients' expectations, high activity in sports...
June 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28534159/arthroscopic-treatment-successfully-treats-posterior-elbow-impingement-in-an-athletic-population
#17
Jason L Koh, Brad A Zwahlen, David W Altchek, Todd A Zimmerman
PURPOSE: Posterior elbow impingement can cause disabling pain and limited motion during activities involving elbow extension. Less understood is whether arthroscopic treatment, compared to open surgery, can result in effective management of pain, loss of range of motion, and return athletes to previous levels of activity. This study determined whether arthroscopic debridement is a safe and effective treatment for posterior elbow impingement and whether it enables athletes to return to a previous level of function...
May 22, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28529010/aneurysmal-bone-cyst-healing-response-with-intramedullary-lengthening-nail
#18
Ahmet Emrah Acan, Onur Basci, Hasan Havitcioglu
We report the treatment process of a pediatric patient with deformity and shortening in the arm after a recurrent aggressive aneurysmal bone cyst (ABC) in the proximal humerus. The patient was treated with curettage of the lesion and lengthening on an intramedullary nail following an osteotomy just distal to the ABC. The period of lengthening was approximately 50 days. At the end of the treatment the lengthening goal was achieved without any neurovascular complication. There was a minimal loss in shoulder hyperabduction due to the deformity of the humeral head...
May 18, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28526640/zero-profile-spacer-versus-cage-plate-construct-in-anterior-cervical-discectomy-and-fusion-for-multilevel-cervical-spondylotic-myelopathy-a-systematic-review-and-meta-analysis
#19
Min-Ji Tong, Guang-Heng Xiang, Zi-Li He, De-Heng Chen, Qian Tang, Hua-Zi Xu, Nai-Feng Tian
BACKGROUD: Anterior cervical discectomy and fusion (ACDF) with plate-screw construct has been gradually applied for multilevel cervical spondylotic myelopathy (CSM) in recent years. However, long cervical plate was associated with complications including breakage or loosening of plate and screws, trachea-esophageal injury, neurovascular injury, and postoperative dysphagia. To reduce these complications, the zero-profile spacer has been introduced. This meta-analysis was performed to compared the clinical and radiological outcomes of zero-profile spacer versus cage-plate construct for the treatment of multilevel cervical spondylotic myelopathy...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28526613/the-role-of-trochanteric-flip-osteotomy-in-fixation-of-certain-acetabular-fractures
#20
Sandeep Gupta, Jagdeep Singh, Jagandeep Singh Virk
PURPOSE: Complete visualization of certain acetabular fractures of posterior wall or column with cranial extension involving superior dome from standard surgical exposures is a challenge. Osteotomy of the greater trochanter has been used to enhance fracture visualization, especially the dome, in posterior and lateral exposures of the acetabulum. It also decreases the need for excessive muscle retraction. The purpose of the study was to investigate the outcome associated with trochanteric flip osteotomy in the management of certain acetabulum fractures...
March 23, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
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