keyword
MENU ▼
Read by QxMD icon Read
search

Micafungin

keyword
https://www.readbyqxmd.com/read/28584152/pharmacodynamic-optimization-for-treatment-of-invasive-candida-auris-infection
#1
Alexander J Lepak, Miao Zhao, Elizabeth L Berkow, Shawn R Lockhart, David R Andes
Candida auris is an emerging, multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median PD target associated with net stasis was a fluconazole AUC/MIC of 26, amphotericin B Cmax/MIC of 0.9, and micafungin AUC/MIC of 54. The micafungin PD targets for C. auris were ≥20-fold lower than other Candida species in this animal model. Clinically relevant micafungin exposures produced the most killing among the three classes...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28584142/micafungin-plasma-levels-are-not-affected-by-continuous-renal-replacement-therapy-experience-in-critically-ill-patients
#2
M G Vossen, D Knafl, M Haidinger, R Lemmerer, M Unger, S Pferschy, W Lamm, A Maier-Salamon, W Jäger, F Thalhammer
Background: Critically ill patients often experience acute kidney injury and the need for renal replacement therapy in the course of their treatment on an ICU. These patients are at an increased risk for candidiasis. Although there have been several reports of micafungin disposition during renal replacement therapy, there are up to this date no data describing the elimination of micafungin during high dose continuous venovenous haemodiafiltration with modified AN69 membranes. The aim of this prospective open label pharmacokinetic study was to assess whether Micafungin plasma levels are affected by continuous haemodiafiltration in critical ill patients using the commonly employed AN69 membrane...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28577122/successful-treatment-of-pulmonary-mucormycosis-caused-by-cunninghamella-bertholletiae-with-high-dose-liposomal-amphotericin-b-10%C3%A2-mg-kg-day-followed-by-a-lobectomy-in-cord-blood-transplant-recipients
#3
Hikari Ota, Hisashi Yamamoto, Muneyoshi Kimura, Hideki Araoka, Takeshi Fujii, Takashi Umeyama, Hideaki Ohno, Yoshitsugu Miyazaki, Daisuke Kaji, Yuki Taya, Aya Nishida, Kazuya Ishiwata, Masanori Tsuji, Shinsuke Takagi, Yuki Asano-Mori, Go Yamamoto, Naoyuki Uchida, Koji Izutsu, Kazuhiro Masuoka, Atsushi Wake, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi
Infection caused by Cunninghamella bertholletiae carries one of the highest mortality rates among mucormycosis, and there are no reported cases that survived from the infection in allogeneic hematopoietic stem cell transplantation recipients occurring before neutrophil engraftment. Here, we present two cases of pulmonary mucormycosis caused by C. bertholletiae occurring before neutrophil engraftment after cord blood transplantation. Both were successfully treated with high-dose liposomal amphotericin B (10 mg/kg/day) combined with micafungin, which was then followed by neutrophil recovery, reduction in immunosuppressive agents, and a subsequent lobectomy...
June 2, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28566496/phosphate-is-the-third-nutrient-monitored-by-tor-in-candida-albicans-and-provides-a-target-for-fungal-specific-indirect-tor-inhibition
#4
Ning-Ning Liu, Peter R Flanagan, Jumei Zeng, Niketa M Jani, Maria E Cardenas, Gary P Moran, Julia R Köhler
The Target of Rapamycin (TOR) pathway regulates morphogenesis and responses to host cells in the fungal pathogen Candida albicans Eukaryotic Target of Rapamycin complex 1 (TORC1) induces growth and proliferation in response to nitrogen and carbon source availability. Our unbiased genetic approach seeking unknown components of TORC1 signaling in C. albicans revealed that the phosphate transporter Pho84 is required for normal TORC1 activity. We found that mutants in PHO84 are hypersensitive to rapamycin and in response to phosphate feeding, generate less phosphorylated ribosomal protein S6 (P-S6) than the WT...
May 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28560585/creation-characterization-and-utilization-of-cryptococcus-neoformans-mutants-sensitive-to-micafungin
#5
Akio Toh-E, Misako Ohkusu, Kiminori Shimizu, Masashi Yamaguchi, Naruhiko Ishiwada, Akira Watanabe, Katsuhiko Kamei
We constructed deletion mutants of Cryptococcus neoformans var neoformans (serotype D) genes encoding late ergosterol biosynthetic pathway enzymes and found that the mutations enhanced susceptibility to various drugs including micafungin, one of the echinocandins, to which wild-type Cryptococcus strains show no susceptibility. Furthermore, through isolation of a mutant resistant to micafungin from a micafungin-sensitive erg mutant and genetic analysis of it, we found that the responsible mutation occurred in the hotspot 2 of FKS1 encoding β-1, 3-glucan synthase, indicating that micafungin inhibited the growth of the erg mutant via inhibiting Fks1 activity...
May 30, 2017: Current Genetics
https://www.readbyqxmd.com/read/28559257/susceptibility-testing-of-the-echinocandins-against-candida-species-in-the-daily-routine-etest%C3%A2-versus-sensititre-yeastone%C3%A2-data-from-a-single-center-in-austria
#6
Maria Aigner, Thomas Erbeznik, Martin Gschwentner, Cornelia Lass-Flörl
Antifungal susceptibility testing of caspofungin, anidulafungin and micafungin against Candida species was performed to evaluate the role of ETest® and Sensititre YeastOne® for antifungal susceptibility testing for daily routine and to survey resistance. 104 Candida species isolates detected from blood cultures were investigated. Determining EUCAST broth microdilution as reference method essential agreement (EA), categorical agreement (CA), very major errors (VME), major (ME) and minor errors (MIN) were assessed reading MICs at 18, 24 and 48 hours...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28537063/-consensus-opinion-on-antifungal-prophylaxis-in-haematologic-patients-results-of-the-promic-project
#7
L Vázquez López, T Villaescusa de la Rosa, R de la Cámara, I Espigado, S Grau Cerrato, M Jurado, M Rovira, M Salavert, D Serrano Simonneau, C Solano Vercet, I Ruiz Camps
OBJECTIVE: Invasive fungal disease (IFD) is an important cause of morbidity and mortality in haematological patients. Antifungal prophylaxis (AFP) is indicated for a number of clinical scenarios in this group of patients. The aim of this study was to reach a consensus on IFD prophylaxis in haematological patients in order to optimize their management. METHODS: A committee of experts in haematology and infectious diseases compiled a survey of 79 items with controversial aspects about antifungal prophylaxis in haematological patients...
May 23, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28513771/species-distribution-and-antifungal-susceptibility-patterns-of-candida-isolates-from-a-public-tertiary-teaching-hospital-in-the-eastern-cape-province-south-africa
#8
P Mnge, B I Okeleye, S D Vasaikar, T Apalata
Candida species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant Candida species. This study aimed to identify the species distribution of Candida isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209 Candida isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar Candida. The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28510690/trichosporonosis-in-pediatric-patients-with-a-hematologic-disorder
#9
Catherine E Foster, Morven S Edwards, Julienne Brackett, Deborah A Schady, C Mary Healy, Carol J Baker
Background.: Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods.: We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute lymphoblastic leukemia at Texas Children's Hospital in Houston, Texas. We also conducted a literature review and identified 16 additional reports of pediatric patients with invasive T asahii infection and an underlying malignant or nonmalignant hematologic disorder...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28506782/the-misleading-effect-of-serum-galactomannan-testing-in-high-risk-hematology-patients-receiving-prophylaxis-with-micafungin
#10
A Vena, E Bouza, A Álvarez-Uría, J Gayoso, P Martin-Rabadan, F Cajuste, J Guinea, J Gómez Castellá, R Alonso, P Munoz
OBJECTIVES: To investigate the performance of the routine serum galactomannan (sGM) assay in the diagnosis of invasive aspergillosis (IA) in high-risk hematology patients receiving prophylaxis with micafungin. METHODS: Retrospective study including all hematological patients who received prophylaxis with micafungin during high-risk IA episodes (neutropenic patients after chemotherapy for acute myeloid leukaemia/myelodysplastic syndrome; allogeneic HSCT during early neutropenic phase or graft-versus-host disease requiring high prednisone doses)...
May 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28493006/activity-of-combined-antifungal-agents-against-multidrug-resistant-candida-glabrata-strains
#11
Laura Bedin Denardi, Jéssica Tairine Keller, Vanessa Oliveira, Débora Alves Nunes Mario, Janio Morais Santurio, Sydney Hartz Alves
In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method in accordance with the Clinical and Laboratory Standards Institute document M27-A3. The checkerboard method was used to evaluate the fractional inhibitory concentration index of the interactions. Cross-resistance was observed among echinocandins; 15% of the isolates resistant to caspofungin were also resistant to anidulafungin and micafungin...
May 10, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28491490/rapid-emergence-of-fks-mutations-in-candida-glabrata-isolates-in-a-peritoneal-candidiasis
#12
Milène Sasso, Claire Roger, Laurence Lachaud
We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata. Isolates recovered before and after treatment were compared by multilocus sequence typing. Results of antifungal susceptibility testing and FKS mutations were reported. The interest of repeating antifungal susceptibility testing for echinocandin molecules during the treatment is discussed and a strategy to research FKS mutations proposed...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28456868/comparative-pathogenicity-of-lomentospora-prolificans-scedosporium-prolificans-isolates-from-mexican-patients
#13
Mariana Elizondo-Zertuche, Alexandra M Montoya, Efrén Robledo-Leal, Idalia Garza-Veloz, Ana L Sánchez-Núñez, Raquel Ballesteros-Elizondo, Gloria M González
We identified 11 Lomentospora prolificans isolates recovered from Mexican patients using phenotypic and molecular characteristics. The identification of isolates was assessed by internal transcribed spacer (ITS rDNA) sequencing. In vitro susceptibility to amphotericin B, fluconazole, voriconazole, posaconazole, caspofungin, anidulafungin and micafungin was determined according to Clinical and Laboratory Standards Institute (CLSI) procedures. Three isolates (07-2239, 11-2242 and 04-2673) were used to induce systemic infection in immunocompetent ICR mice...
April 29, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28446325/-current-status-and-future-perspectives-of-primary-antifungal-prophylaxis-in-patients-with-hematological-malignancies-review
#14
Yan Li, Li Yu
Invasive fungal diseases (IFD) are associated with considerable morbidity and mortality in patients with hematological malignancies. Primary antifungal prophylaxis (PAP) is effective for decreasing incidence of IFD, and the patients will be more tolerable to chemotherapy with less cost and better prognosis. Antifungal drugs as fluconazole, itraconazole, posaconazole, caspofungin and micafungin are all recommended for PAP by many consensus and guidelines. The PAP will be more scientific, appropriate and effective with the development of studies about predicting risk-stratification for IFD, new drugs, pharmacokinetics and integrated prophylaxis...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28438935/candida-guilliermondii-complex-is-characterized-by-high-antifungal-resistance-but-low-mortality-a-report-on-22-cases-of-candidemia
#15
Laura Judith Marcos-Zambrano, Mireia Puig-Asensio, Felipe Pérez-García, Pilar Escribano, Carlos Sánchez-Carrillo, Oscar Zaragoza, Belén Padilla, Manuel Cuenca-Estrella, Benito Almirante, M Teresa Martin-Gómez, Patricia Muñoz, Emilio Bouza, Jesús Guinea
Objectives: The objectives of our study were to describe the characteristics of patients infected with C. guilliermondii candidemia and to perform an in-depth microbiological characterization of isolates and compare them with those of patients with C. albicans candidemia.Methods: We described the risk factors and outcome of 22 patients with candidemia caused by C. guilliermondii complex. Incident isolates were identified using molecular techniques, and susceptibility to fluconazole, anidulafungin and micafungin was studied...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28437176/echinocandins-in-ocular-therapeutics
#16
Akash Patil, Soumyajit Majumdar
Fungal infections of the eye, especially fungal keratitis and endophthalmitis, are major causes of concern and if left untreated could lead to vision loss. Currently, natamycin (polyene antifungal) is the only commercially available topical agent used for the treatment of ocular fungal infections. The other antifungals, belonging to the polyene and azole classes, are used off-label in treating ocular infections and are administered topically, orally, intraocularly, or systemically. Even though their use through the different routes of administration has shown favorable outcomes, challenges such as poor ocular penetration, low bioavailability, ocular toxicity, and systemic side effects limit their utility...
June 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28431933/caspofungin-versus-micafungin-in-the-incidence-of-hepatotoxicity-in%C3%A2-patients-with-normal-to-moderate-liver-failure
#17
Yuichi Shibata, Mao Hagihara, Hideo Kato, Noriyo Kawasumi, Jun Hirai, Naoya Nishiyama, Nobuhiro Asai, Yusuke Koizumi, Yuka Yamagishi, Katsuhiko Matsuura, Hiroshige Mikamo
BACKGROUND: One of the major adverse events of caspofungin and micafungin is hepatotoxicity, however, there are few reports compared the incidence of hepatotoxicity between caspofungin and micafungin. Herein, the primary objective of this study was to compare the incidence of hepatotoxicity between caspofungin and micafungin treatments for patients with fungal or suspected fungal infection. METHODS: In total, 201 patients [caspofungin group: 66 patients; micafungin group: 135 patients] treated with echinocandins from April 2014 to November 2015 at Aichi Medical University Hospital...
June 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28429246/comparison-of-efficacy-and-safety-of-caspofungin-versus-micafungin-in-pediatric-allogeneic-stem-cell-transplant-recipients-a-retrospective-analysis
#18
Natalia Maximova, Giulia Schillani, Roberto Simeone, Alessandra Maestro, Davide Zanon
INTRODUCTION: The high morbidity and mortality associated with invasive fungal infections (IFIs) provide the rationale for antifungal prophylaxis in immuno-compromised pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Caspofungin and micafungin are antifungal agents of interest for prophylaxis of IFIs because of their potency against Candida and minimal toxicity or interactions with other drugs. Few studies have demonstrated the safety and efficacy of such echinocandins as prophylaxis for IFIs in patients undergoing HSCT...
May 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28420849/the-effective-treatment-of-lung-infection-due-to-scedosporium-prolificans-with-voriconazole-and-surgery
#19
Seiya Masukane, Yoshihiro Kitahara, Joe Okumoto, Keisuke Sasaki, Kikuo Nakano
Scedosporium prolificans is a fungus that has demonstrated resistance against most currently available antifungal agents and which causes a rapidly disseminating and potentially fatal infection. A 68-year-old woman presented with a fever and consolidation in the lung field. Her symptoms and inflammatory reaction did not improve despite treatment with tazobactam/piperacillin, meropenem, and micafungin. Scedosporium prolificans was detected from the patient's bronchial lavage fluid, and we initiated treatment with voriconazole...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28416539/candida-auris-comparison-of-the-eucast-and-clsi-reference-microdilution-mics-for-eight-antifungal-compounds-and-associated-tentative-ecoffs
#20
M C Arendrup, Anupam Prakash, Joseph Meletiadis, Cheshta Sharma, Anuradha Chowdhary
C. auris is an emerging multidrug-resistant yeast. So far, all but two susceptibility testing studies have examined ≤50 isolates and mostly with the CLSI method. We investigated CLSI and EUCAST MICs for 123 C. auris isolates and eight antifungals and evaluated various methods for ECOFF determination.MICs (mg/L) were determined using CLSI M27-A3 and EUCAST E.Def 7.3. ANOVA analysis with Bonferroni's multiple comparison test and Pearson analysis were used on log2MICs (significant, p<0.05). The percent agreement (±0->2 two-fold dilutions) between the methods was calculated...
April 17, 2017: Antimicrobial Agents and Chemotherapy
keyword
keyword
79659
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"