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https://www.readbyqxmd.com/read/29213345/the-management-of-chronic-pulmonary-aspergillosis-the-uk-national-aspergillosis-centre-approach
#1
REVIEW
Firas Maghrabi, David W Denning
Purpose of Review: Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbidities, complex clinical picture, drug interactions, toxicities and intolerances. Recent Findings: First line treatment is oral itraconazole or voriconazole. In the event of intolerance or toxicity, patients may be swapped from itraconazole to voriconazole or vice versa...
2017: Current Fungal Infection Reports
https://www.readbyqxmd.com/read/29189615/multi-modal-treatment-of-rhinocerebral-mucormycosis-in-a-pediatric-patient-with-relapsed-pre-b-acute-lymphoblastic-leukemia
#2
Zephyr D Dworsky, John S Bradley, Matthew T Brigger, Alice L Pong, Dennis John Kuo
A 17-year-old female developed invasive rhinocerebral mucormycosis during intensive re-induction chemotherapy for relapsed pre-B acute lymphoblastic leukemia. Due to the high case fatality rate for invasive mucormycosis in profoundly immunosuppressed patients, an aggressive treatment regimen was pursued. In addition to the standard of care treatments with intravenous amphotericin and aggressive surgical debridements, she received intraventricular amphotericin to the brain via an Ommaya reservoir, hyperbaric oxygen treatments, filgrastim, intravenous immunoglobulin and anti-fungal in vitro synergy testing to allow for more targeted antifungal therapy with the addition of micafungin...
November 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29185089/pharmacoeconomic-evaluation-of-micafungin-versus-caspofungin-as-definitive-therapy-for-candidaemia-and-invasive-candidiasis-ic-in-turkey
#3
C F Neoh, E Senol, A Kara, E C Dinleyici, S J Turner, D C M Kong
Micafungin was shown to be as efficacious as caspofungin in treating patients with candidaemia and invasive candidiasis (IC). However, it remains unknown if micafungin or caspofungin is a cost-effective definitive therapy for candidaemia and IC in Turkey. The present study aimed to determine the economic impact of using micafungin versus caspofungin for treatment of candidaemia and IC in the Turkish setting. A decision analytic model was constructed and was populated with data (i.e. transition probabilities, duration of initial antifungal treatment, reasons for treatment failure, percentage of patients who stepped down to oral fluconazole, and duration on oral fluconazole) obtained from a published randomised clinical trial...
November 28, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29172033/in-vitro-antifungal-susceptibility-of-clinical-and-environmental-isolates-of-aspergillus-fumigatus-and-aspergillus-flavus-in-brazil
#4
Laura Bedin Denardi, Bianca Hoch Dalla-Lana, Francielli Pantella Kunz de Jesus, Cecília Bittencourt Severo, Janio Morais Santurio, Régis Adriel Zanette, Sydney Hartz Alves
The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2...
November 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29141316/-a-clinical-analysis-of-micafungin-treatment-of-pulmonary-invasive-fungal-infection-in-pediatric-patients-with-acute-leukemia-or-post-hematopoietic-stem-cells-transplantation
#5
K Huang, K Y Qiu, L L Deng, J P Fang, Y Li, H X Guo, D H Zhou
Objective: To investigate the efficacy and safety of micafungin (MCF) for pulmonary invasive fungal disease (PIFD) in pediatric patients with acute leukemia or post hematopoietic stem cells transplantation. Method: Twenty-five neutropenic PIFD children with acute leukemia or post hematopoietic stem cells transplantation in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were selected from January 2012 to June 2015, including 12 males and 13 females, age range 2-15 (average 6.2±2.0) years. There were 12 cases of acute leukemia (AL) after chemotherapy, 4 cases of acute leukemia (AL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and 9 cases of β-thalassemia major after allo-HSCT...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29125713/outbreak-of-invasive-aspergillosis-in-heart-transplant-recipients-the-role-of-screening-computed-tomography-scans-in-asymptomatic-patients-and-universal-antifungal-prophylaxis
#6
Dima Kabbani, Livia Goldraich, Heather Ross, Coleman Rotstein, Shahid Husain
BACKGROUND: Delays in diagnosing invasive pulmonary aspergillosis (IA), a significant cause of morbidity and mortality among heart transplant recipients (HTRs), may impact on successful treatment. The appropriate screening strategy for IA in these patients remains undefined, particularly in the setting of nosocomial outbreaks. We describe our experience employing chest computed tomography (CT) scans as a screening method for IA. In addition, we comment on antimicrobial prophylaxis in HTRs in the setting of an outbreak...
November 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29109159/overtreatment-of-asymptomatic-candiduria-among-hospitalized-patients-a-multi-institutional-study
#7
David M Jacobs, Thomas J Dilworth, Nicholas D Beyda, Anthony M Casapao, Dana R Bowers
Candiduria is common in hospitalized patients and asymptomatic candiduria contributes to antifungal overuse. Guidelines for asymptomatic candiduria do not recommend antifungal use, rather the elimination of predisposing factors. It is unknown whether these recommendations are being followed. The primary objective of this study was to characterize candiduria management among hospitalized patients. This was a retrospective cohort study of a random sample of 305 hospitalized patients with candiduria at four U...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29103728/short-communication-cold-atmospheric-plasma-inactivation-of-prototheca-zopfii-isolated-from-bovine-milk
#8
E Tyczkowska-Sieron, J Markiewicz, B Grzesiak, H Krukowski, A Glowacka, J Tyczkowski
Mastitis is a serious bovine diseases that can be caused by Prototheca zopfii, yeast-like algae belonging to the family Chlorellaceae. The substantial economic losses and health damage associated with bovine mastitis emphasize the need to develop effective strategies aimed at control of the infection. Unfortunately, P. zopfii is highly resistant to most common antibacterial and antifungal agents, as well as to heat treatment. We report here the first attempt to use cold atmospheric plasma to inactivate this pathogen...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29081623/cardiac-safety-of-high-dose-micafungin
#9
Kayla R Stover, John D Cleary
No abstract text is available yet for this article.
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29074432/healthcare-workers-hands-as-a-vehicle-for-the-transmission-of-virulent-strains-of-candida-spp-a-virulence-factor-approach
#10
Karina Mayumi Sakita, Daniella Renata Faria, Eliane Martins da Silva, Flávia Kelly Tobaldini-Valério, Erika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patricia de Souza Bonfim-Mendonça
BACKGROUND: Although the majority of Candida infections are thought to come from endogenous sources, the healthcare workers' (HCWs) hands are being increasingly reported as vehicles for the transmission of pathogens. The aim of the present study was to evaluate the susceptibility of yeast isolated from the HCWs' hands and ICU (Intensive Care Unit) surfaces to antifungal agents and to determine the virulence potential and the genetic similarity between the same. METHODS: The susceptibility of yeasts from the HCWs' hands (n = 57) and ICU surfaces (n = 98) to conventional antifungals (fluconazole, voriconazole, amphotericin B and micafungin) was evaluated using the broth microdilution assay accordance with CLSI M27-A3...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29070656/molecular-diagnostics-of-arthroconidial-yeasts-frequent-pulmonary-opportunists
#11
Engin Kaplan, Abdullah M S Al-Hatmi, Macit Ilkit, A H G Gerrits van den Ende, Ferry Hagen, Jacques F Meis, G Sybren de Hoog
Magnusiomyces capitatus and Saprochaete clavata are members of the clade of arthroconidial yeasts that represent emerging opportunistic pulmonary pathogens in immunocompromised patients. Given that standard rDNA identification often provides confusing results, in this study, we analyzed 34 isolates with the goal of finding new genetic markers for classification using multilocus sequencing and amplified fragment length polymorphism (AFLP). Interspecific similarity using rDNA markers [internal transcribed spacer (ITS) and large subunit] was in the range of 96-99%, whereas that of protein-coding loci (Rbp2, Act, and Tef1α) was lower at 89...
October 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29038263/in-vitro-combination-of-isavuconazole-with-echinocandins-against-azole-susceptible-and-resistant-aspergillus-spp
#12
A Raffetin, V Courbin, V Jullien, E Dannaoui
The in vitro combinations of isavuconazole with echinocandins were evaluated against 30 Aspergillus spp. by a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all the strains. With the agar-based method, indifferent interactions were found for all the strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergy in 4/30 strains, and antagonism in 2/30 strains...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28994449/postantifungal-effect-of-micafungin-against-candida-albicans-candida-dubliniensis-and-candida-africana-in-the-presence-and-absence-of-serum
#13
Tamás Kardos, Qasem Saleh, Renátó Kovács, Rudolf Gesztelyi, Gábor Kardos, Aliz Bozó, Zoltán Tóth, László Majoros
We compared the micafungin killing rate and postantifungal effect (PAFE) at 4, 16 and 32 mg/L in RPMI-1640 and in 50% serum against the C. albicans complex. In RPMI-1640 PAFEs were 1.5 - >19.4, 9.7 - >20.1 and 15.9 - >18.5 hours for C. albicans, C. africana and C. dubliniensis, respectively. In 50% serum PAFEs decreased sharply to 0 - 1.7 hours for all three species; killing rates were always negative. Short growth inhibition without killing in 50% serum suggests that micafungin PAFE has a limited role in the eradication of the C...
October 10, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28994001/comparison-between-etest-and-broth-microdilution-methods-for-testing-itraconazole-resistant-aspergillus-fumigatus-susceptibility-to-antifungal-combinations
#14
Laura Bedin Denardi, Jéssica Tairine Keller, Maria Isabel de Azevedo, Vanessa Oliveira, Fernanda Baldissera Piasentin, Cecília Bittencourt Severo, Janio Morais Santurio, Sydney Hartz Alves
The checkerboard broth microdilution assay (BMD) is the most frequently used method for the in vitro evaluation of drug combinations. However, its use to evaluate the effect of antifungal drugs on filamentous fungi is sometimes associated with endpoint-reading difficulties, and different degrees of interaction are assigned to the same drug combination. We evaluated combinations of the azoles, itraconazole, posaconazole, and voriconazole, with the echinocandins, anidulafungin, caspofungin, and micafungin, against 15 itraconazole-resistant Aspergillus fumigatus clinical strains via the checkerboard BMD and Etest assay...
October 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28993334/choosing-optimal-antifungal-agents-to-prevent-fungal-infections-in-non-neutropenic-critically-ill-patients-trial-sequential-analysis-network-meta-analysis-and-pharmacoeconomic-analysis
#15
Yan Wang, Jiao Xie, Yuanming Xing, Lu Chen, Ying Li, Ti Meng, Weihua Dong, Xue Wang, Yalin Dong
The use of antifungal interventions in critically ill patients prior to invasive fungal infection (IFI) being microbiologically confirmed as well as the preferred drug are still controversial. A systematic literature search was performed to identify randomized controlled trials (RCTs) that have compared untargeted antifungal treatments applied to non-neutropenic critically ill patients. The primary outcomes were all-cause mortality and proven IFI rates. A random-effects model was used with trial sequential analyses (TSA), a network meta-analysis (NMA) was conducted to obtain indirect evidence, and a cost-effectiveness analysis using a decision-analytic model was completed from the patient perspective over a lifetime horizon...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28992253/in-vitro-antifungal-susceptibility-patterns-of-planktonic-and-sessile-candida-kefyr-clinical-isolates
#16
Fruzsina Nagy, Aliz Bozó, Zoltán Tóth, Lajos Daróczi, László Majoros, Renátó Kovács
The activity of fluconazole, amphotericin B, caspofungin and micafungin was determined using XTT-based fungal damage assays against planktonic cells, early and mature biofilms of Candida kefyr. Median MICs of planktonic cells were 0.25 mg/l, 0.25 mg/l, 0.5 mg/l, and 0.06 mg/l for fluconazole, amphotericin B, caspofungin, and micafungin, respectively. Fluconazole showed at least 50% fungal damage at ≥4 mg/l (51.5% ± 6.63% to 78.38% ± 1.44%) and at ≥128 mg/l (57.88% ± 9.2% to 67.25% ± 9...
August 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28992116/in-vitro-activity-of-echinocandins-against-562-clinical-yeast-isolates-from-a-romanian-multicentre-study
#17
Mihai Mares, Bogdan Minea, Valentin Nastasa, Irina Rosca, Andra-Cristina Bostanaru, Iosif Marincu, Vasilica Toma, Violeta Corina Cristea, Carmen Murariu, Mariana Pinteala
The study presents the echinocandin susceptibility profile of a multi-centre collection of pathogenic yeast isolates from Romanian tertiary hospitals. The 562 isolates were identified using ID32C strips, MALDI-TOF MS and DNA sequencing. Minimal inhibitory concentrations (MICs) of caspofungin (CAS), micafungin (MCA), and anidulafungin (ANI) were assessed and interpreted according to EUCAST guidelines. Minimal fungicidal concentrations (MFC) were determined by plating content from the clear MIC wells. The activity was considered fungicidal at MFC/MIC ≤ 4...
August 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28988900/biofilm-forming-capacity-of-blood-borne-candida-albicans-strains-and-effects-of-antifungal-agents
#18
Hanni Turan, Müge Demirbilek
Infections related to Candida albicans biofilms and subsequent antifungal resistance have become more common with the increased use of indwelling medical devices. Regimens for preventing fungal biofilm formation are needed, particularly in high-risk patients. In this study, we investigated the biofilm formation rate of multiple strains of Candida albicans (n=162 clinical isolates), their antifungal susceptibility patterns, and the efficacy of certain antifungals for preventing biofilm formation. Biofilm formation was graded using a modified Christensen's 96-well plate method...
October 5, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28984722/safety-and-efficacy-of-micafungin-in-extremely-low-birthweight-infants
#19
Simone S Schüller, Carina Bauer, Lukas Unterasinger, Angelika Berger
Little is known about side effects of micafungin in extremely low birthweight (ELBW) infants. In a retrospective single center study 19 ELBW infants were analyzed for micafungin efficacy and safety. At a mean±SD daily dosage of 7.5 ± 2.0mg/kg no clinically relevant side effects were observed. A significant increase of liver enzymes was reversible after treatment.
September 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28983822/in-vitro-activity-of-micafungin-against-biofilms-of-candida-albicans-candida-glabrata-and-candida-parapsilosis-at-different-stages-of-maturation
#20
Małgorzata Prażyńska, Tomasz Bogiel, Eugenia Gospodarek-Komkowska
Candida spp. is able to form a biofilm, which is considered resistant to the majority of antifungals used in medicine. The aim of this study was to evaluate the in vitro activity of micafungin against Candida spp. biofilms at different stages of their maturation (2, 6, and 24 h). We assessed the inhibitory effect of micafungin against 78 clinical isolates of Candida spp., growing as planktonic or sessile cells, by widely recommended broth microdilution method. The in vitro effect on sessile cells viability was evaluated by colorimetric reduction assay...
October 5, 2017: Folia Microbiologica
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