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https://www.readbyqxmd.com/read/29788854/-myocardial-clefts-incidental-findings-in-parainfectious-myocarditis
#1
Florian Berger, Christopher Hansi, Tilo Niemann
Myocardial Clefts - Incidental Findings in Parainfectious Myocarditis Abstract. We report a 23-year-old woman with parainfectious myocarditis due to gastroenteritis. A transthoracic echocardio-graphy revealed a recess in the left inferobasal ventricle. For further investigation, cardiac magnetic resonance imaging was initiated, which revealed a myocardial cleft, a harmless structural variation of the heart. Cardiac magnetic resonance is a non-invasive imaging technique with a high spatial and temporal resolution that enables a precise depiction of the cardiac anatomy and therefore allows for a differentiation between normal and pathological structural variations of the heart...
2018: Praxis
https://www.readbyqxmd.com/read/29773357/acute-transverse-myelitis-following-an-opsoclonus-myoclonus-syndrome-an-unusual-presentation
#2
Thomas Simon, Emmanuel Cheuret, Léa Fiedler, Catherine Mengelle, Eloïse Baudou, Kumaran Deiva
Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an acute transverse myelitis. Screening for neuroblastoma was negative and extensive infectious screening revealed an active HHV-6 infection confirmed by blood and cerebrospinal fluid PCR...
May 8, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29727049/multifactorial-analysis-of-opsoclonus-myoclonus-syndrome-etiology-tumor-vs-no-tumor-in-a-cohort-of-356-us-children
#3
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee
BACKGROUND: Pediatric opsoclonus-myoclonus syndrome (OMS) presents a paradox of etiopathogenesis: A neuroblastic tumor (NB) is found in only one half of the cases, the others are ascribed to infections or designated as idiopathic. METHOD: From an IRB-approved observational study of 356 US children with OMS, secondary analysis of "etiology" and related factors was performed on a well-characterized cohort. The "Tumor" (n = 173) and "No Tumor" groups (n = 183), as defined radiologically, were compared according to multiple factors considered potentially differentiating...
May 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29613895/infectious-myelopathies
#4
Marie F Grill
PURPOSE OF REVIEW: This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS: Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections)...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29322962/etiologic-spectrum-and-prognosis-in-noncompressive-acute-transverse-myelopathies-an-experience-of-80-patients-at-a-tertiary-care-facility
#5
Shuchit Pandey, Ravindra K Garg, Hardeep S Malhotra, Amita Jain, Kiran P Malhotra, Neeraj Kumar, Rajesh Verma, Praveen K Sharma
INTRODUCTION: We evaluated the spectrum of acquired demyelinating and inflammatory disorders in patients presenting with an acute transverse myelopathy. We also studied differences between an acute idiopathic transverse myelitis and myelitis resulting from other etiologies. MATERIALS AND METHODS: Eighty consecutive patients with acute transverse myelopathy were included. At inclusion, clinical profile, serum and cerebrospinal fluid parameters, brain and spinal cord magnetic resonance imaging, and visual evoked potentials were obtained...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29273615/longitudinally-extensive-transverse-myelitis-after-campylobacter-jejuni-enteritis
#6
Yudy Llamas, Karl Hazel, Patrick Nicholson, Lisa Costelloe
Campylobacter jejuni infection is well-known to precipitate Guillain-Barré syndrome through an immune-mediated attack on the peripheral nervous system. Molecular mimicry between C. jejuni lipo-oligosaccharides on the surface of infectious agents and human gangliosides in the peripheral nerves induces cross-reactive immune responses. Although gangliosides also occur in the central nervous system (CNS), autoimmune CNS disorders rarely follow C jejuni infections. However, longitudinally extensive transverse myelitis commonly has a parainfectious cause, triggered by a wide range of micro-organisms including viruses and bacteria...
April 2018: Practical Neurology
https://www.readbyqxmd.com/read/29262438/autoimmune-encephalitis-in-critical-care-optimizing-immunosuppression
#7
Daniel B Rubin, Ayush Batra, Ivana Vodopivec, Henrikas Vaitkevicius
Autoimmune diseases affecting the nervous systems are a common cause of admission to the intensive care unit (ICU). Although there exist several well-described clinical syndromes, patients more commonly present with progressive neurologic dysfunction and laboratory and radiographic evidence of central nervous system (CNS) inflammation. In the critical care setting, the urgency to intervene to prevent permanent damage to the nervous system and secondary injury from the systemic manifestations of these syndromes often conflicts with diagnostic uncertainty...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29204217/parainfectious-ocular-flutter-and-truncal-ataxia-and-dengue
#8
Viroj Wiwanitkit
No abstract text is available yet for this article.
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29198162/neurobrucellosis-presenting-as-clinically-definite-amyotrophic-lateral-sclerosis
#9
Andreas A Argyriou, Panagiotis Karanasios, Apostolos Papapostolou, Paraskevi Loukopoulou, Alexandra Makridou, Markos Marangos, Nicolaos Makris
Purpose/Aim: We describe the first case of a patient with neurobrucellosis presenting with clinically-definite ALS. MATERIAL AND METHODS: A 48-year old male patient, in whom the diagnoses of systemic brucellosis and clinically definite ALS were undoubtedly confirmed and were eventually causally interrelated. The disease-specific antibiotic therapy was unsuccessful to slow the evolution of the motor neuron disease and the patient became non ambulatory over time. RESULTS: Considering the close temporal association of ALS onset with the systemic Brucella infection and consequent antigenic stimuli, we might suggest that human brucellosis might have triggered a process of motor neuron degeneration in keeping with neurobrucellosis, primarily due to parainfectious mechanism...
December 29, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28978599/unusual-case-of-acute-urinary-retention-in-a-young-female
#10
Belinda Zer Hui Chern, Shivani Rajaraman, Geetika Verma, Kenneth Wei Jian Heng
We report an unusual case of a 17-year-old young female presenting to the emergency department with varicella infection, acute urinary retention (AUR) and no other neurological deficits. An MRI of the spine confirmed the diagnosis of acute transverse myelitis. Positive serum IgG antibodies against varicella zoster virus (VZV) suggested a parainfectious aetiology. The patient eventually developed weakness and a sensory level from the third thoracic dermatome on day 2 of hospitalisation. Awareness that AUR can precede other neurological deficits in VZV transverse myelitis will prevent misdiagnosis and allow for the prompt treatment of this debilitating illness...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28806453/neurologic-complications-associated-with-the-zika-virus-in-brazilian-adults
#11
Ivan Rocha Ferreira da Silva, Jennifer A Frontera, Ana Maria Bispo de Filippis, Osvaldo Jose Moreira do Nascimento
Importance: There are no prospective cohort studies assessing the incidence and spectrum of neurologic manifestations secondary to Zika virus (ZIKV) infection in adults. Objective: To evaluate the rates of acute ZIKV infection among patients hospitalized with Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis. Design, Setting, and Participants: A prospective, observational cohort study was conducted at a tertiary referral center for neurological diseases in Rio de Janeiro, Brazil, between December 5, 2015, and May 10, 2016, among consecutive hospitalized adults (>18 years of age) with new-onset acute parainfectious or neuroinflammatory disease...
October 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28553394/parainfectious-ocular-flutter-and-truncal-ataxia-in-association-with-dengue-fever
#12
Rohan R Mahale, Anish Mehta, Kiran Buddaraju, Rangasetty Srinivasa
Ocular flutter is an eye movement disorder characterized by purely horizontal rapid saccadic oscillations lasting for a few minutes which stops spontaneously. Postinfectious ocular flutter and truncal ataxia are a rare entity. There are reported cases of opsoclonus myoclonus ataxia in association with dengue virus infection. However, there are no reported cases of parainfectious ocular flutter and truncal ataxia in association with dengue virus infection. Hereby, we report a child with dengue fever who had ocular flutter and truncal ataxia...
January 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28549713/childhood-opsoclonus-myoclonus-syndrome-a-case-series-from-tunisia
#13
Nedia Ben Achour, Saloua Mrabet, Ibtihel Rebai, Ines Abid, Hanene Benrhouma, Hedia Klaa, Aida Rouissi, Ichraf Kraoua, Ilhem Ben Youssef Turki
INTRODUCTION: Opsoclonus myoclonus syndrome (OMS) is a rare immune-mediated disorder characterized by opsoclonus, myoclonus, ataxia and behavioral changes. The aim of our study was to investigate the epidemiology, clinical features, etiological aspects and outcome of OMS in Tunisian children. METHODS: We conducted a retrospective study over 11years (2005-2016) including all patients aged under 18years who were managed for newly diagnosed OMS in a tertiary care research centre for children with neurological symptoms...
October 2017: Brain & Development
https://www.readbyqxmd.com/read/28497710/the-complex-diagnostic-challenge-in-children-with-non-central-nervous-system-cancer-and-cerebellar-mutism
#14
Kathleen Helton, Amy L Patterson, Raja B Khan, Zsila S Sadighi
Multiple etiologies should be considered in the differential diagnosis of immunocompromised patients with non-central nervous system cancer and viral infections who develop mutism. Acute cerebellitis, caused by infections or by neurotoxicity resulting from chemotherapy; paraneoplastic cerebellar degeneration; atypical posterior reversible encephalopathy syndrome; and acute disseminated encephalomyelitis may all cause mutism in such patients. This condition warrants prompt recognition and may require treatment with immunotherapy, as it may be an immune-mediated process...
August 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28291512/recurrent-trimethoprim-sulfamethoxazole-induced-aseptic-meningitis-with-associated-ampicillin-induced-myoclonic-twitches%C3%A2
#15
Anna L Fisse, Katrin Straßburger-Krogias, Ralf Gold, Gisa Ellrichmann
OBJECTIVE: To report a case of recurrent trimethoprim-sulfamethoxazole-induced aseptic meningitis with associated ampicillin-induced myoclonic twitches. MATERIALS AND METHODS: The patient was investigated using cerebral computed tomography, magnetic resonance imaging, cerebrospinal fluid examination, and electroencephalography. Written informed consent was obtained from the patient for access to clinical files for research purposes and publication. RESULTS: We present a middle-aged woman with two recurrent episodes of aseptic meningitis after treatment with trimethoprim-sulfamethoxazole...
July 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28120141/autoimmune-movement-disorders-a-clinical-and-laboratory-approach
#16
REVIEW
Josephe Archie Honorat, Andrew McKeon
Autoimmune movement disorders are caused by an aberrant immune response to neural self-antigens. These disorders may be paraneoplastic, parainfectious, or (most commonly) idiopathic. The neurological presentations are diverse, and sometimes multifocal. Movement disorders can occur as part of the spectrum with phenotypes including chorea, myoclonus, ataxia, CNS hyperexcitability (including stiff-person syndrome), dystonia, and parkinsonism. Symptoms are subacute in onset and may have a fluctuating course. The best characterized disorders are unified by neural autoantibodies identified in serum or cerebrospinal fluid...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28000909/-language-disorders-in-acute-cerebellitis-beyond-dysarthria
#17
D Barragan-Martinez, N Nunez-Enamorado, M Berenguer-Potenciano, N Villora-Morcillo, A Martinez de Aragon, A Camacho-Salas
INTRODUCTION: Acute cerebellitis is one of the main causes of cerebellar syndrome in infancy. Among the wide range of manifestations, headache and ataxia being the most predominant, we can find other less frequent, although nonetheless interesting, ones, such as language disorders, which go beyond the well-known cerebellar dysarthria. The different combinations in which the symptoms can appear, especially when not accompanied by ataxia, make the condition a real challenge for the clinician...
January 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/27928148/acute-transverse-myelitis-associated-with-salmonella-bacteremia-a-case-report
#18
Mary E Richert, Hillary Hosier, Adam S Weltz, Eric S Wise, Manjari Joshi, Jose J Diaz
BACKGROUND Acute transverse myelitis (ATM) is an uncommon and often overlooked complication of certain bacterial and viral infections that can have a rapid onset and result in severe neurological deficits.  CASE REPORT This case report describes a previously healthy 28-year-old woman who presented to the trauma center after developing acute paralysis and paresthesias of all four extremities within the span of hours. The initial presumptive diagnosis was spinal cord contusion due to a fall versus an unknown mechanism of trauma, but eventual laboratory studies revealed Salmonella bacteremia, indicating a probable diagnosis of parainfectious ATM...
December 8, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27878586/-parainfectious-optic-neuritis-with-macular-infiltrate-in-neisseria-meningitidis-b-meningitis
#19
A Chronopoulos, F Hoogewoud, H Steffen, G Thumann
OBJECTIVE: We report on the case of a young immunocompetent female patient with parainfectious optic neuritis and macular inflitrate due to Neisseria meningitidis B meningitis. METHOD: Case report RESULTS: A 22-year-old female patient was admitted to the emergency department for intensive care treatment with a strong suspicion of meningitis. Clinical and serological parameters were indicative of a bacterial genesis of the meningitis. By analysis of the cerebrospinal fluid (CSF) Neisseria meningitidis type B could be detected...
October 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27801769/adult-onset-opsoclonus-myoclonus-syndrome-associated-with-ganglionic-acetylcholine-receptor-autoantibody
#20
Jonathan R Galli, Stacey L Clardy, M Mateo Paz Soldán
INTRODUCTION: Opsoclonus-myoclonus syndrome (OMS) may have a toxin induced, parainfectious, or paraneoplastic etiology. Several autoantibodies have been associated with adult-onset OMS, most commonly antineuronal nuclear antibody 2 (Ri), and it is most frequently associated with breast or small cell lung cancer. The nicotinic ganglionic acetylcholine receptor autoantibody (α3-AChR Ab) has not been described in association. CASE REPORT: A 46-year-old woman was evaluated for symptoms of oscillopsia, tremor, gait imbalance, and mild cognitive deficits that began 6 weeks prior...
November 2016: Neurologist
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