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myalgias guidelines

D B Kadam, Sonali Salvi, Ajay Chandanwale
The World Health Organization (WHO) has coined the term expanded dengue to describe cases which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. This has incorporated several atypical findings of dengue. Dengue virus has not been enlisted as a common etiological agent in several conditions like encephalitis, Guillain Barre syndrome. Moreover it is a great mimic of co-existing epidemics like Malaria, Chikungunya and Zika virus disease, which are also mosquito-borne diseases. The atypical manifestations noted in dengue can be mutisystemic and multifacetal...
July 2016: Journal of the Association of Physicians of India
Eli Muchtar, Daniele Derudas, Michelle Mauermann, Teerin Liewluck, Angela Dispenzieri, Shaji K Kumar, David Dingli, Martha Q Lacy, Francis K Buadi, Suzanne R Hayman, Prashant Kapoor, Nelson Leung, Rajshekhar Chakraborty, Wilson Gonsalves, Stephen Russell, John A Lust, Yi Lin, Ronald S Go, Steven Zeldenrust, Robert A Kyle, S Vincent Rajkumar, Morie A Gertz
OBJECTIVE: To characterize the natural history of immunoglobulin light chain amyloidosis-associated myopathy and to provide guidelines for recognition. PATIENTS AND METHODS: Fifty-one patients with systemic immunoglobulin light chain amyloidosis and biopsy-confirmed muscle amyloid deposition diagnosed between January 1, 1995, and December 31, 2015, were included in this study. RESULTS: Common presenting symptoms were muscle weakness in 49 patients (96%), dysphagia in 23 (45%), myalgia in 17 (33%), macroglossia in 17 (33%), jaw claudication in 13 (25%), and hoarseness in 9 (18%)...
October 2016: Mayo Clinic Proceedings
Stephanie Mlacker, Golsa Shafa, Adam S Aldahan, Vidhi V Shah, Sahal Samarkandy, Keyvan Nouri
BACKGROUND: Zika virus (ZIKV) is an arbovirus within the Flaviviridae family, the recent spread of which has promoted public concern. METHODS: This study outlines the clinical features, potential for teratogenicity, diagnosis, and treatment of ZIKV infection. RESULTS: Zika virus is transmitted through the bite of an infected Stegomyia (= Aedes) mosquito, blood transfusion, sexual intercourse, and perinatal routes. Infection has been characterized as mildly symptomatic...
September 21, 2016: International Journal of Dermatology
Sriram Pothapregada, Banupriya Kamalakannan, Mahalaskhmy Thulasingham, Srinivasan Sampath
OBJECTIVE: To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry. MATERIALS AND METHODS: All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16...
July 2016: Journal of Global Infectious Diseases
Dolores Lovera, Celia Martinez de Cuellar, Soraya Araya, Sara Amarilla, Nicolás Gonzalez, Carlos Aguiar, Julia Acuña, Antonio Arbo
BACKGROUND: Dengue shock syndrome (DSS) represents one of the most severe manifestations of dengue virus (DNV) infection. The objective of the present study was to analyze the clinical and laboratory characteristics, risk factors and outcome of DSS in children. METHODOLOGY: Patients (pts) <15 years old admitted with DSS during the 2012-2013 outbreak of serotype 2 of DNV in Paraguay were included. Demographic , clinical, and laboratory data of patients with/without DSS were analyzed...
July 22, 2016: Pediatric Infectious Disease Journal
Christa C van Bunderen, Paul Lips, Mark H Kramer, Madeleine L Drent
BACKGROUND: Current guidelines state that the goals of growth hormone (GH) therapy in adults should be an appropriate clinical response, avoidance of side effects, and an IGF-1 value within the age-adjusted reference range. There are no published studies on the target level for IGF-1 that offer specific guidance in this regard. OBJECTIVES: To compare low-normal and high-normal target levels of IGF-1 on efficacy and safety of GH treatment. METHODS: A randomized, open-label, clinical trial including thirty-two adults from one university hospital receiving GH therapy for at least one year with a stable IGF-1 concentration between -1 and 1 SD score (SDS)...
June 2016: European Journal of Internal Medicine
Antonio Barrera-Cruz, Rita Delia Díaz-Ramos, Ana Belem López-Morales, Concepción Grajales-Muñiz, Arturo Viniegra-Osorio, Jaime Antonio Zaldívar-Cervera, José Jesús Arriaga-Dávila
Infection Zika virus is an emerging disease in the Americas region, which is caused by Zika virus (ZIKV), an arbovirus of the flavivirus genus. The ZIKV is transmitted by the bite of Aedes mosquitoes, both in urban and jungle area. After the mosquito bite, the disease symptoms usually appear after an incubation period of three to twelve days. The infection may be asymptomatic or presented with fever and not purulent conjunctivitis, headache, myalgia, arthralgia, asthenia, maculopapular rash, edema in lower limbs and, less frequently, retro-orbital pain, anorexia, vomiting, diarrhea or pain abdominal...
March 2016: Revista Médica del Instituto Mexicano del Seguro Social
Herman Kosasih, Bachti Alisjahbana, Nurhayati, Quirijn de Mast, Irani F Rudiman, Susana Widjaja, Ungke Antonjaya, Harli Novriani, Nugroho H Susanto, Hadi Jusuf, Andre van der Ven, Charmagne G Beckett, Patrick J Blair, Timothy H Burgess, Maya Williams, Kevin R Porter
BACKGROUND: Dengue has emerged as one of the most important infectious diseases in the last five decades. Evidence indicates the expansion of dengue virus endemic areas and consequently the exponential increase of dengue virus infections across the subtropics. The clinical manifestations of dengue virus infection include sudden fever, rash, headache, myalgia and in more serious cases, spontaneous bleeding. These manifestations occur in children as well as in adults. Defining the epidemiology of dengue in a given area is critical to understanding the disease and devising effective public health strategies...
February 2016: PLoS Neglected Tropical Diseases
J Davies, R Tippet, A Watson, J Metcalfe
Catheter-directed thrombolysis is becoming increasingly considered in the treatment of acute ileofemoral deep vein thrombosis. By targeting occlusive thrombi early, it is possible to mitigate the symptoms of post-thrombotic syndrome, which include oedema, pain, and ulceration. NICE guidelines recommend the use of catheter-directed thrombolysis in those without contraindications to treatment. The main risk of thrombolysis is bleeding; however, other side effects such as allergy have been reported. We present a 50-year-old man who presented with an acute left-sided ileofemoral deep vein thrombosis...
February 8, 2016: Phlebology
Marjet J A M Braamskamp, Gisle Langslet, Brian W McCrindle, David Cassiman, Gordon A Francis, Claude Gagné, Daniel Gaudet, Katherine M Morrison, Albert Wiegman, Traci Turner, D Meeike Kusters, Elinor Miller, Joel S Raichlen, Jenny Wissmar, Paul D Martin, Evan A Stein, John J P Kastelein
OBJECTIVE: Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant disorder leading to premature atherosclerosis. Guidelines recommend initiating statins early to reduce low-density lipoprotein cholesterol (LDL-C). Studies have evaluated rosuvastatin in children aged ≥10 years, but its efficacy and safety in younger children is unknown. METHODS: Children with HeFH and fasting LDL-C >4.92 mmol/L (190 mg/dL) or >4.10 mmol/L (>158 mg/dL) with other cardiovascular risk factors received rosuvastatin 5 mg daily...
November 2015: Journal of Clinical Lipidology
A S Omrani, S Shalhoub
The Middle East Respiratory Coronavirus (MERS-CoV) was first isolated from a patient who died with severe pneumonia in June 2012. As of 19 June 2015, a total of 1,338 MERS-CoV infections have been notified to the World Health Organization (WHO). Clinical illness associated with MERS-CoV ranges from mild upper respiratory symptoms to rapidly progressive pneumonia and multi-organ failure. A significant proportion of patients present with non-respiratory symptoms such as headache, myalgia, vomiting and diarrhoea...
November 2015: Journal of Hospital Infection
Mitchell Busch, Gerald Erickson
Chikungunya fever is a viral infection caused by the Chikungunya virus that causes abrupt onset of fever, debilitating arthralgias and myalgias, and some rare but serious atypical presentations in infected patients. This mosquito-borne virus may not be familiar to North American healthcare providers. This article describes the causes, epidemiology, pathophysiology, clinical presentation, diagnostic and screening measures, management guidelines, and future research prospects for Chikungunya infection.
October 2015: JAAPA: Official Journal of the American Academy of Physician Assistants
Patrick Cherin, Isabelle Marie, Mauricette Michallet, Eric Pelus, Jacques Dantal, Jean-Charles Crave, Jean-Christophe Delain, Jean-François Viallard
Immunoglobulin (IG) therapy is actually used for a broad range of diseases including primary and secondary immunodeficiency disorders, and autoimmune diseases. This therapy is available for intravenous (IV) and subcutaneous (SC) administration. The efficacy of the IG therapy has been demonstrated in numerous studies and across different diseases. Generally, IG infusions are well tolerated; however some well-known adverse reactions, ranging from mild to severe, are associated with the therapy. The most common adverse reactions including headache, nausea, myalgia, fever, chills, chest discomfort, skin and anaphylactic reactions, could arise immediately during or after the infusion...
January 2016: Autoimmunity Reviews
Dee Ann Stults Bragg, Anne Walling
Metabolic syndrome is associated with an elevated risk of cardiovascular disease and premature mortality. When metabolic syndrome includes lipid abnormalities, management goals are weight loss and cardiovascular risk management through lifestyle modifications (eg, diet, exercise), and, when appropriate, lowering of lipid levels with pharmacotherapy. Healthy diets are recommended, particularly the Mediterranean diet. Patients also should set a goal of at least 30 minutes of moderate to vigorous exercise on most, preferably all, days of the week...
August 2015: FP Essentials
Ramesh Saeedi, Kevin Johns, Jiri Frohlich, Matthew T Bennett, Gregory Bondy
BACKGROUND: HIV-infected patients on antiretroviral therapy frequently develop dyslipidemias and, despite therapy with potent lipid-lowering agents, a high percentage does not achieve guideline recommended lipid targets. In this study, we examined the efficacy of combination treatment with a statin and the cholesterol transport blocker, ezetimibe, vs. monotherapy with a statin in HIV-infected patients not achieving lipid goals. METHODS: This was a 12-week, prospective, randomized, open-label clinical trial...
2015: Lipids in Health and Disease
Yekaterina Sherman, Rose Karanicolas, Brittany DiMarco, Nancy Pan, Alexa B Adams, Laura V Barinstein, L Nandini Moorthy, Thomas J A Lehman
BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation. METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation...
July 2015: Pediatrics
Jason L Rengo, Damien M Callahan, Patrick D Savage, Philip A Ades, Michael J Toth
INTRODUCTION: Statins have well-known benefits on cardiovascular mortality, though up to 15% of patients experience side effects. With guidelines from the American Heart Association, American College of Cardiology, and American Diabetes Association expected to double the number of statin users, the overall incidence of myalgia and myopathy will increase. METHODS: We evaluated skeletal muscle structure and contractile function at the molecular, cellular, and whole tissue levels in 12 statin tolerant and 12 control subjects...
February 2016: Muscle & Nerve
Mirko Faber, Susanne Schink, Anne Mayer-Scholl, Christoph Ziesch, Ralph Schönfelder, Heidi Wichmann-Schauer, Klaus Stark, Karsten Nöckler
BACKGROUND: Food safety authorities discovered that wild boar meat products contaminated with Trichinella spiralis had entered the food chain in Germany in March 2013. Public health authorities issued guidelines for health professionals including post-exposure prophylaxis (PEP) using mebendazole and advised the public to seek medical advice if exposed. Our objective was to identify factors associated with the development of trichinellosis and to evaluate post exposure prophylaxis. METHODS: Persons who reported to local public health departments as exposed were interviewed concerning exposure, symptoms, and medication...
June 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Chulyong Park, Sungyeul Choi, Dohyung Kim, Jaechan Park, Saerom Lee
BACKGROUND: Occupational radiation exposure causes certain types of cancer, specifically hematopoietic diseases like leukemia. In Korea, radiation exposure is monitored and recorded by law, and guidelines for compensation of radiation-related diseases were implemented in 2001. However, thus far, no occupation-related disease was approved for compensation under these guidelines. Here, we report the first case of radiation-related disease approved by the compensation committee of the Korea Workers' Compensation and Welfare Service, based on the probability of causation...
2014: Annals of Occupational and Environmental Medicine
Kristi L Koenig, Cassondra Majestic, Michael J Burns
Ebola Virus Disease (EVD) has become a public health emergency of international concern. The World Health Organization and Centers for Disease Control and Prevention have developed guidance to educate and inform healthcare workers and travelers worldwide. Symptoms of EVD include abrupt onset of fever, myalgias, and headache in the early phase, followed by vomiting, diarrhea and possible progression to hemorrhagic rash, life-threatening bleeding, and multi-organ failure in the later phase. The disease is not transmitted via airborne spread like influenza, but rather from person-to-person, or animal to person, via direct contact with bodily fluids or blood...
November 2014: Western Journal of Emergency Medicine
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