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https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#1
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27884454/-management-of-adverse-effects-related-to-human-immunoglobulin-therapy-recommendations-for-clinical-practice
#2
I Marie, P Chérin, M Michallet, E Pelus, J Dantal, J-C Crave, J-C Delain, J-F Viallard
Both intravenous and subcutaneous immunoglobulins are therapeutic modalities approved in various conditions, including primary and secondary immune deficiencies and autoimmune disorders. To date, immunoglobulins have more often been considered as a safe medication, with minor adverse effects such as hypertension, fever and chills, nausea, myalgia or headache. However, with the wider use of immunoglobulins in the treatment of autoimmune diseases, severe side effects have also been reported to occur in immunoglobulin-treated patients, especially anaphylaxis, aseptic meningitis, acute renal impairment, thrombotic events as well as haematological manifestations...
November 21, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27834407/-painful-temporomandibular-dysfunctions-diagnosis-and-treatment
#3
F Lobbezoo, G Aarab, W Knibbe, M Koutris, C J Warnsinck, P Wetselaar, C M Visscher
Painful temporomandibular disorders (TMD pain) are common among the general population. The most common sub diagnoses are myalgia (jaw-muscle pain) and arthralgia (temporomandibular joint pain). The aetiology of TMD pain has a multifactorial nature, and its diagnosis and possible treatment often require a multidisciplinary approach. The most recent insights in the diagnosis and treatment of TMD pain are based on the multidisciplinary guideline 'Chronic Orofacial Pain' that was developed by the Dutch Society of Headache Patients and was published in 2013...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27826219/a-dengue-infection-without-bleeding-manifestations-in-an-adult-with-immune-thrombocytopenic-purpura
#4
N D B Ehelepola, M B K Gunawardhana, T N Sudusinghe, S K D Sooriyaarachchi, S P Manchanayake, K L R Kalupahana
BACKGROUND: Dengue is the most prevalent and fast spreading arboviral infection affecting people. No specific drug is available to treat dengue. Thrombocytopenia with potential of serious hemorrhages is one of the hall mark features of dengue. Immune thrombocytopenic purpura is an autoimmune disease causing thrombocytopenia. If a patient with that gets dengue, we expect severe thrombocytopenia with bleeding manifestations. Only a handful of such cases were reported before, and they were managed in different ways...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27798247/rechallenging-statin-therapy-in-veterans-with-statin-induced-myopathy-post-vitamin-d-replenishment
#5
Jenny H Kang, Quynh-Nhu Nguyen, Juleann Mutka, Quang A Le
BACKGROUND: Statins are the primary class of medications used to lower cholesterol and reduce risks for coronary heart disease. However, statin muscular adverse effects are one of the main reasons for statin nonadherence and a barrier to cardiovascular risk reduction. OBJECTIVES: The primary objective of our study was to examine the effect of replenishing vitamin D on statin-induced myopathy in veteran patients who failed to maintain statin therapy in a pharmacist-run ambulatory care setting...
October 24, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27788886/evaluation-of-long-term-safety-and-efficacy-of-omalizumab-in-elderly-patients-with-uncontrolled-allergic-asthma
#6
Tugba Songul Tat, Aykut Cilli
BACKGROUND: Severe asthma management in elderly patients may be difficult because of increased comorbid conditions, polypharmacy, physiologic changes that occur with aging, incorrect use of inhaler devices, and poor adherence. OBJECTIVE: To evaluate the long-term safety and efficacy of the anti-IgE antibody omalizumab in elderly (aged ≥65 years) patients with uncontrolled allergic asthma. METHODS: The efficiency and adverse effects of omalizumab treatment were evaluated based on data extracted from medical records...
November 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27759344/expanded-dengue
#7
REVIEW
D B Kadam, Sonali Salvi, Ajay Chandanwale
The World Health Organization (WHO) has coined the term expanded dengue to describe cases which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. This has incorporated several atypical findings of dengue. Dengue virus has not been enlisted as a common etiological agent in several conditions like encephalitis, Guillain Barre syndrome. Moreover it is a great mimic of co-existing epidemics like Malaria, Chikungunya and Zika virus disease, which are also mosquito-borne diseases. The atypical manifestations noted in dengue can be mutisystemic and multifacetal...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27712634/systemic-immunoglobulin-light-chain-amyloidosis-associated-myopathy-presentation-diagnostic-pitfalls-and-outcome
#8
Eli Muchtar, Daniele Derudas, Michelle Mauermann, Teerin Liewluck, Angela Dispenzieri, Shaji K Kumar, David Dingli, Martha Q Lacy, Francis K Buadi, Suzanne R Hayman, Prashant Kapoor, Nelson Leung, Rajshekhar Chakraborty, Wilson Gonsalves, Stephen Russell, John A Lust, Yi Lin, Ronald S Go, Steven Zeldenrust, Robert A Kyle, S Vincent Rajkumar, Morie A Gertz
OBJECTIVE: To characterize the natural history of immunoglobulin light chain amyloidosis-associated myopathy and to provide guidelines for recognition. PATIENTS AND METHODS: Fifty-one patients with systemic immunoglobulin light chain amyloidosis and biopsy-confirmed muscle amyloid deposition diagnosed between January 1, 1995, and December 31, 2015, were included in this study. RESULTS: Common presenting symptoms were muscle weakness in 49 patients (96%), dysphagia in 23 (45%), myalgia in 17 (33%), macroglossia in 17 (33%), jaw claudication in 13 (25%), and hoarseness in 9 (18%)...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27650823/origin-of-the-zika-virus-revealed-a-historical-journey-across-the-world
#9
Stephanie Mlacker, Golsa Shafa, Adam S Aldahan, Vidhi V Shah, Sahal Samarkandy, Keyvan Nouri
BACKGROUND: Zika virus (ZIKV) is an arbovirus within the Flaviviridae family, the recent spread of which has promoted public concern. METHODS: This study outlines the clinical features, potential for teratogenicity, diagnosis, and treatment of ZIKV infection. RESULTS: Zika virus is transmitted through the bite of an infected Stegomyia (= Aedes) mosquito, blood transfusion, sexual intercourse, and perinatal routes. Infection has been characterized as mildly symptomatic...
September 21, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27621562/clinically-profiling-pediatric-patients-with-dengue
#10
Sriram Pothapregada, Banupriya Kamalakannan, Mahalaskhmy Thulasingham, Srinivasan Sampath
OBJECTIVE: To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry. MATERIALS AND METHODS: All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16...
July 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27455442/clinical-characteristics-and-risk-factors-of-dengue-shock-syndrome-in-children
#11
Dolores Lovera, Celia Martinez de Cuellar, Soraya Araya, Sara Amarilla, Nicolás Gonzalez, Carlos Aguiar, Julia Acuña, Antonio Arbo
BACKGROUND: Dengue shock syndrome (DSS) represents one of the most severe manifestations of dengue virus (DNV) infection. The objective of the present study was to analyze the clinical and laboratory characteristics, risk factors and outcome of DSS in children. METHODOLOGY: Patients (pts) <15 years old admitted with DSS during the 2012-2013 outbreak of serotype 2 of DNV in Paraguay were included. Demographic , clinical, and laboratory data of patients with/without DSS were analyzed...
July 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27118206/comparison-of-low-normal-and-high-normal-igf-1-target-levels-during-growth-hormone-replacement-therapy-a-randomized-clinical-trial-in-adult-growth-hormone-deficiency
#12
Christa C van Bunderen, Paul Lips, Mark H Kramer, Madeleine L Drent
BACKGROUND: Current guidelines state that the goals of growth hormone (GH) therapy in adults should be an appropriate clinical response, avoidance of side effects, and an IGF-1 value within the age-adjusted reference range. There are no published studies on the target level for IGF-1 that offer specific guidance in this regard. OBJECTIVES: To compare low-normal and high-normal target levels of IGF-1 on efficacy and safety of GH treatment. METHODS: A randomized, open-label, clinical trial including thirty-two adults from one university hospital receiving GH therapy for at least one year with a stable IGF-1 concentration between -1 and 1 SD score (SDS)...
June 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26960050/-technical-guidelines-for-the-prevention-diagnosis-and-treatment-of-zika-virus-infection
#13
Antonio Barrera-Cruz, Rita Delia Díaz-Ramos, Ana Belem López-Morales, Concepción Grajales-Muñiz, Arturo Viniegra-Osorio, Jaime Antonio Zaldívar-Cervera, José Jesús Arriaga-Dávila
Infection Zika virus is an emerging disease in the Americas region, which is caused by Zika virus (ZIKV), an arbovirus of the flavivirus genus. The ZIKV is transmitted by the bite of Aedes mosquitoes, both in urban and jungle area. After the mosquito bite, the disease symptoms usually appear after an incubation period of three to twelve days. The infection may be asymptomatic or presented with fever and not purulent conjunctivitis, headache, myalgia, arthralgia, asthenia, maculopapular rash, edema in lower limbs and, less frequently, retro-orbital pain, anorexia, vomiting, diarrhea or pain abdominal...
March 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/26872216/the-epidemiology-virology-and-clinical-findings-of-dengue-virus-infections-in-a-cohort-of-indonesian-adults-in-western-java
#14
Herman Kosasih, Bachti Alisjahbana, Nurhayati, Quirijn de Mast, Irani F Rudiman, Susana Widjaja, Ungke Antonjaya, Harli Novriani, Nugroho H Susanto, Hadi Jusuf, Andre van der Ven, Charmagne G Beckett, Patrick J Blair, Timothy H Burgess, Maya Williams, Kevin R Porter
BACKGROUND: Dengue has emerged as one of the most important infectious diseases in the last five decades. Evidence indicates the expansion of dengue virus endemic areas and consequently the exponential increase of dengue virus infections across the subtropics. The clinical manifestations of dengue virus infection include sudden fever, rash, headache, myalgia and in more serious cases, spontaneous bleeding. These manifestations occur in children as well as in adults. Defining the epidemiology of dengue in a given area is critical to understanding the disease and devising effective public health strategies...
February 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26861476/systemic-inflammatory-response-syndrome-following-catheter-directed-thrombolysis-of-acute-iliofemoral-deep-venous-thrombosis
#15
J Davies, R Tippet, A Watson, J Metcalfe
Catheter-directed thrombolysis is becoming increasingly considered in the treatment of acute ileofemoral deep vein thrombosis. By targeting occlusive thrombi early, it is possible to mitigate the symptoms of post-thrombotic syndrome, which include oedema, pain, and ulceration. NICE guidelines recommend the use of catheter-directed thrombolysis in those without contraindications to treatment. The main risk of thrombolysis is bleeding; however, other side effects such as allergy have been reported. We present a 50-year-old man who presented with an acute left-sided ileofemoral deep vein thrombosis...
February 8, 2016: Phlebology
https://www.readbyqxmd.com/read/26687694/efficacy-and-safety-of-rosuvastatin-therapy-in-children-and-adolescents-with-familial-hypercholesterolemia-results-from-the-charon-study
#16
Marjet J A M Braamskamp, Gisle Langslet, Brian W McCrindle, David Cassiman, Gordon A Francis, Claude Gagné, Daniel Gaudet, Katherine M Morrison, Albert Wiegman, Traci Turner, D Meeike Kusters, Elinor Miller, Joel S Raichlen, Jenny Wissmar, Paul D Martin, Evan A Stein, John J P Kastelein
OBJECTIVE: Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant disorder leading to premature atherosclerosis. Guidelines recommend initiating statins early to reduce low-density lipoprotein cholesterol (LDL-C). Studies have evaluated rosuvastatin in children aged ≥10 years, but its efficacy and safety in younger children is unknown. METHODS: Children with HeFH and fasting LDL-C >4.92 mmol/L (190 mg/dL) or >4.10 mmol/L (>158 mg/dL) with other cardiovascular risk factors received rosuvastatin 5 mg daily...
November 2015: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26452615/middle-east-respiratory-syndrome-coronavirus-mers-cov-what-lessons-can-we-learn
#17
REVIEW
A S Omrani, S Shalhoub
The Middle East Respiratory Coronavirus (MERS-CoV) was first isolated from a patient who died with severe pneumonia in June 2012. As of 19 June 2015, a total of 1,338 MERS-CoV infections have been notified to the World Health Organization (WHO). Clinical illness associated with MERS-CoV ranges from mild upper respiratory symptoms to rapidly progressive pneumonia and multi-organ failure. A significant proportion of patients present with non-respiratory symptoms such as headache, myalgia, vomiting and diarrhoea...
November 2015: Journal of Hospital Infection
https://www.readbyqxmd.com/read/26406179/an-overview-of-chikungunya-virus
#18
Mitchell Busch, Gerald Erickson
Chikungunya fever is a viral infection caused by the Chikungunya virus that causes abrupt onset of fever, debilitating arthralgias and myalgias, and some rare but serious atypical presentations in infected patients. This mosquito-borne virus may not be familiar to North American healthcare providers. This article describes the causes, epidemiology, pathophysiology, clinical presentation, diagnostic and screening measures, management guidelines, and future research prospects for Chikungunya infection.
October 2015: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/26384525/management-of-adverse-events-in-the-treatment-of-patients-with-immunoglobulin-therapy-a-review-of-evidence
#19
REVIEW
Patrick Cherin, Isabelle Marie, Mauricette Michallet, Eric Pelus, Jacques Dantal, Jean-Charles Crave, Jean-Christophe Delain, Jean-François Viallard
Immunoglobulin (IG) therapy is actually used for a broad range of diseases including primary and secondary immunodeficiency disorders, and autoimmune diseases. This therapy is available for intravenous (IV) and subcutaneous (SC) administration. The efficacy of the IG therapy has been demonstrated in numerous studies and across different diseases. Generally, IG infusions are well tolerated; however some well-known adverse reactions, ranging from mild to severe, are associated with the therapy. The most common adverse reactions including headache, nausea, myalgia, fever, chills, chest discomfort, skin and anaphylactic reactions, could arise immediately during or after the infusion...
January 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26280341/metabolic-syndrome-hyperlipidemia
#20
REVIEW
Dee Ann Stults Bragg, Anne Walling
Metabolic syndrome is associated with an elevated risk of cardiovascular disease and premature mortality. When metabolic syndrome includes lipid abnormalities, management goals are weight loss and cardiovascular risk management through lifestyle modifications (eg, diet, exercise), and, when appropriate, lowering of lipid levels with pharmacotherapy. Healthy diets are recommended, particularly the Mediterranean diet. Patients also should set a goal of at least 30 minutes of moderate to vigorous exercise on most, preferably all, days of the week...
August 2015: FP Essentials
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