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R B P Torrecilha, Y T Utsunomiya, A M Bosco, B F Almeida, P P Pereira, L G Narciso, D C M Pereira, L Baptistiolli, L Calvo-Bado, O Courtenay, C M Nunes, P C Ciarlini
Intensity of peripheral parasite infection has an important role in the transmission of Leishmania spp. from one host to another. As parasite load quantification is still an expensive procedure to be used routinely in epidemiological surveillance, the use of surrogate predictors may be an important asset in the identification of dogs with high transmitting ability. The present study examined whether common clinical and laboratory alterations can serve as predictors of peripheral parasitism in dogs naturally infected with Leishmania spp...
September 15, 2016: Preventive Veterinary Medicine
Viktoria Schwarz, Katrin Bachelier, Stephan H Schirmer, Christian Werner, Ulrich Laufs, Michael Böhm
BACKGROUND: Moderate consumption of red wine is associated with fewer cardiovascular events. We investigated whether red wine consumption counteracts the adverse vascular effects of cigarette smoking. METHODS: Participants smoked 3 cigarettes alone or after drinking a titrated volume of red wine. Clinical chemistry, blood counts, plasma cytokine enzyme-linked immunosorbent assays, immunomagnetic separation of CD14(+) monocytes for gene expression analysis, fluorescence-activated cell sorting for microparticles, and isolation of circulating mononuclear cells to measure telomerase activity were performed, and urine cotinine levels were quantified...
January 2017: American Journal of Medicine
Reshma Gopal Kini, Jayaprakash Chandrashekhar
INTRODUCTION: Haematological changes are the most common complications encountered in malaria. There is significant correlation between several of the haematological parameters and the clinical profile, prognosis and mortality in malaria. White cell counts and differentials are among the most basic and primary investigations done in a patient presenting with fever of short duration. AIM: This study analyzes the numerical and morphological changes in White Blood Cells (WBCs) in peripheral blood in patients with acute malaria in endemic region in an effort to get a picture of specific changes that could be identified by basic investigations...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Dimple Anand, Sumit Ray, Seema Bhargava, Lalit M Srivastava, Ashish Garg, Imran Gafoor, Rahul Singh, Debashish Dhar
AIM OF THE STUDY: Initial differentiation of sepsis from systemic inflammatory response syndrome (SIRS) is of prime importance for early institution of appropriate treatment. This study aimed to compare the differential diagnostic efficacy of absolute eosinophil count (AEC - a routinely available economic marker) with total leukocyte count (TLC) and procalcitonin (PCT - a costly marker available only in specialized settings). MATERIALS AND METHODS: In this prospective observational study, 170 patients of sepsis (severe sepsis = 125; SIRS = 45) were enrolled...
May 2016: Indian Journal of Critical Care Medicine
Özge Korkmaz, Hakki Kaya, Osman Beton, Ali Zorlu, Sabahattin Göksel, Müslim Gül, İlker İnce, Öcal Berkan, Mehmet Birhan Yılmaz
OBJECTIVE: Coronary artery bypass graft surgery in one of the most effective and widely used methods employed in the treatment of ischemic heart disease, but many factors to various degrees are directly associated with perioperative and postoperative problems. In this study, we evaluated the relationship between preoperative eosinophil count and postoperative mortality in patients who underwent coronary artery bypass graft operation. METHODS: A total of 241 patients (157 males, 84 females) who underwent isolated on-pump coronary artery bypass graft operation between 2011 and 2013 in two centers were evaluated retrospectively...
April 18, 2016: Heart Surgery Forum
Ramesh B Jagtap, Amit Gupta, Sushama R Chaphalkar
AIM: In India, dairy industries are important for the livelihood of small scale farmers and dairy owners. Tropical theileriosis, mostly affecting dairy cattle and buffaloes is a major threat to dairy and related industries. Tropical theileriosis is caused by Theileria annulata, a hemoprotozoan parasite transmitted by Ixodid ticks of Hyalomma spp. In the present study, we examined the clinical signs, hematological parameters and flow cytometric profile of whole blood in 30 theileriosis affected crossbred cattle...
December 2015: Veterinary World
C E Lavoignet, P Le Borgne, H Slimani, M Forato, C Kam, P Kauffmann, F Lefebvre, P Bilbault
BACKGROUND: Several studies in internal medicine departments and in intensive care units have shown the interest of eosinopenia in the diagnosis of infected patients. The aim of the present study was to test the value of this marker in the Emergency Department (ED), either alone or associated with other common sepsis markers. METHODS: We report on a retrospective and monocentric study. We reviewed the complete blood count (CBC) of all patients visiting the ED during one-week duration (in February 2014)...
November 2016: La Revue de Médecine Interne
Yusuke S Hori, Satoshi Kodera, Yasunori Sato, Toshiaki Shiojiri
BACKGROUND: Eosinopenia has been shown to be a prognostic factor in bacteremia, chronic obstructive pulmonary disease, and myocardial infarction, but studies focusing on cerebral infarction are lacking. METHODS: We conducted a retrospective study of 405 patients admitted to the Asahi General Hospital from June 2011 to September 2014 with a diagnosis of cerebral infarction within 24 hours after symptom onset. Differences in mortality, mortality associated with infection, and the prevalence of infection within 2 months of hospital admission were assessed between patients with and without eosinopenia at presentation...
June 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Hatice Ezgi Baris, Safa Baris, Elif Karakoc-Aydiner, Ibrahim Gokce, Nurdan Yildiz, Dilek Cicekkoku, Ismail Ogulur, Ahmet Ozen, Harika Alpay, Isil Barlan
UNLABELLED: The severity and duration of immunosuppression caused by corticosteroids (CSs) usage have not been extensively studied. We aimed to investigate the effects of CSs on the various compartments of immune system in relation to timing of initiation and persistence of therapy. Pediatric patients with idiopathic nephrotic syndrome (NS) treated with 2 mg/kg/day prednisolone and healthy control (HC) were enrolled. Blood samples were drawn for immunologic analyses at baseline and at the first and second weeks and first, second, and third months of CS therapy in addition to first and second weeks and first, second, and third months of discontinuation...
May 2016: European Journal of Pediatrics
Jenessa L Gjeltema, Brigid Troan, Atis Muehlenbachs, Lindy Liu, Alexandre J Da Silva, Yvonne Qvarnstrom, Jeremy R Tobias, Michael R Loomis, Ryan S De Voe
CASE DESCRIPTION A 22-year-old male gorilla (Gorilla gorilla gorilla) housed in a zoo was evaluated for signs of lethargy, head-holding, and cervical stiffness followed by development of neurologic abnormalities including signs of depression, lip droop, and tremors. CLINICAL FINDINGS Physical examination under general anesthesia revealed a tooth root abscess and suboptimal body condition. A CBC and serum biochemical analysis revealed mild anemia, neutrophilia and eosinopenia consistent with a stress leukogram, and signs consistent with dehydration...
February 1, 2016: Journal of the American Veterinary Medical Association
Alberto Tobón-Castaño, Esteban Mesa-Echeverry, Andrés Felipe Miranda-Arboleda
Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods...
2015: Journal of Tropical Medicine
Yusuke S Hori, Toru Fukuhara, Mizuho Aoi, Yoichiro Namba
BACKGROUND: Neutrophilia is associated with brain injury and is frequently accompanied by eosinopenia. Although eosinopenia is a poor prognostic indicator for various diseases, its significance in intracranial events has not been investigated. METHODS: We retrospectively included 22 pediatric patients (≤18 years old) who experienced traumatic intracranial hemorrhage between 2002 and 2015. Patients were divided into two groups based on the presence or absence of eosinopenia on admission, i...
2016: Pediatric Neurosurgery
Mohammad Hossein Rahimi-Rad, Behzad Asgari, Negar Hosseinzadeh, Ali Eishi
BACKGROUND: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause of hospitalization and mortality. Recent studies have shown the usefulness of eosinopenia in predicting the outcomes of patients admitted to the intensive care unit. This study examined the association of eosinopenia with the outcomes of patients with AECOPD. METHODS: This is a prospective study. Patients with AECOPD were divided into two cohorts: patients with eosinopenia and those without eosinopenia...
March 2015: Mædica
Katri Backman, Kirsi Nuolivirta, Hertta Ollikainen, Matti Korppi, Eija Piippo-Savolainen
BACKGROUND: Infant bronchiolitis may be the first manifestation of asthma. AIM: To evaluate the association of early-childhood risk or protective factors for asthma and lung function reduction in adults 30 years after bronchiolitis in infancy. METHODS: Forty-seven former bronchiolitis patients attended the clinical study at the median age of 29.5 years, including doctoral examination and measurement of post-bronchodilator lung function with flow-volume spirometry...
November 2015: Pediatric Allergy and Immunology
Emmanuel Jesús Escobar-Valdivia, Julio Edgardo González-Aguirre, Eunice Rebeca Carrillo-Cisneros, Karla Carolina Guerra-Leza, Roberto Mercado-Longoría
BACKGROUND: Predicting mortality in the intensive care unit (ICU) is one of the biggest challenges in critical care medicine. Several studies have linked the presence of eosinopenia with adverse outcomes in different populations. METHODS: We performed a case control study to determine whether the eosinophil count at ICU admission was a predictor of hospital mortality. We included data from patients 18 years or older admitted to the medical or surgical ICU in a university hospital in northern of Mexico...
2015: Journal of Intensive Care
Ashraf M Abdel-Moneim, Mona Y El-Toweissy, Awatef M Ali, Abd Allah M Awad Allah, Hanaa S Darwish, Ismail A Sadek
This study aims to evaluate the protective role of curcumin (Curc) against hematological and biochemical changes, as well as renal pathologies induced by lead acetate [Pb (CH3COO)2·3H2O] treatment. Male albino rats were intraperitoneally treated with Pb(2+) (25 mg of lead acetate/kg b.w., once a day) alone or in combination with Curc (30 mg of Curc/kg b.w., twice a day) for 7 days. Exposure of rats to Pb(2+) caused significant decreases in hemoglobin (Hb) content, hematocrit (Ht) value, and platelet (Plt) count, while Pb(2+)-related leukocytosis was accompanied by absolute neutrophilia, monocytosis, lymphopenia, and eosinopenia...
November 2015: Biological Trace Element Research
H Lee, C W Lim, H P Hong, J W Ju, Y T Jeon, J W Hwang, H P Park
In this study, we evaluated the efficacy of the discharge Acute Physiology and Chronic Health Evaluation (APACHE) II score in predicting post-intensive care unit (ICU) mortality and ICU readmission during the same hospitalisation in a surgical ICU. Of 1190 patients who were admitted to the ICU and stayed >48 hours between October 2007 and March 2010, 23 (1.9%) died and 86 (7.2%) were readmitted after initial ICU discharge, with 26 (3.0%) admitted within 48 hours. The area under the receiver operating characteristics curve of the discharge and admission APACHE II scores in predicting in-hospital mortality was 0...
March 2015: Anaesthesia and Intensive Care
Yi-Xuan Dai, Chuan-Bing Shi, Bo-Ta Cui, Min Wang, Guo-Zhong Ji, Fa-Ming Zhang
Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by patchy or diffuse eosinophilic infiltration of the bowel wall to a variable depth and various gastrointestinal manifestations. We describe a case of severe eosinophilic gastroenteritis presenting as frequent bowel obstruction and diarrhea in a 35-year-old man. The patient was misdiagnosed and underwent surgery because of intestinal obstruction when he was first admitted to a local hospital. Then he was misdiagnosed as having Crohn's disease in another university teaching hospital...
November 21, 2014: World Journal of Gastroenterology: WJG
Emma M Haapaniemi, Meri Kaustio, Hanna L M Rajala, Arjan J van Adrichem, Leena Kainulainen, Virpi Glumoff, Rainer Doffinger, Heikki Kuusanmäki, Tarja Heiskanen-Kosma, Luca Trotta, Samuel Chiang, Petri Kulmala, Samuli Eldfors, Riku Katainen, Sanna Siitonen, Marja-Liisa Karjalainen-Lindsberg, Panu E Kovanen, Timo Otonkoski, Kimmo Porkka, Kaarina Heiskanen, Arno Hänninen, Yenan T Bryceson, Raija Uusitalo-Seppälä, Janna Saarela, Mikko Seppänen, Satu Mustjoki, Juha Kere
The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulation polyendocrinopathy enteropathy X-linked-like syndrome. Here, we immunologically characterized 3 patients with de novo activating mutations in the DNA binding or dimerization domains of STAT3 (p.K392R, p.M394T, and p.K658N, respectively). The patients displayed multiorgan autoimmunity, lymphoproliferation, and delayed-onset mycobacterial disease...
January 22, 2015: Blood
Angélica María Sánchez-Sarmiento, Ticiana Zwarg, Renata Carolina Fernandes-Santos, Thaís Guimarães-Luiz, Alexander Genoy-Puerto, Eliana Reiko Matushima
Deforestation and habitat fragmentation are major threats to the conservation status of New World primates, such as the howler monkey (Alouatta caraya) in Brazil, where vegetation destruction is often associated with projects such as Small Hydro Power Plant (SHP) construction. The resulting stress from the implementation of this type of enterprise may be a factor that influences individual susceptibility against pathogens and can determine the success or failure of mitigation measures proposed by responsible and/or requested companies by environmental agencies...
March 2015: American Journal of Primatology
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