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https://www.readbyqxmd.com/read/28724166/iron-pharmacokinetics-in-women-with-iron-deficiency-anaemia-following-a-single-oral-dose-of-a-novel-formulation-of-tardyferon-prolonged-release-ferrous-sulphate
#1
Andrew Leary, Laurence Barthe, Thierry Clavel, Claudie Sanchez, Zahida Issiakhem, Bruno Paillard, Jean-Marc Edmond
Numerous iron-containing preparations are available on the market; these vary in dosage, salt, chemical state of iron (ferric or ferrous) and in the iron delivery process (immediate or prolonged-release). Tardyferon® is a prolonged-release tablet containing 80 mg ferrous sulphate. The formulation has recently been modified; changes to the excipients which constitute the inert formulation matrix have allowed a decrease in tablet size for easier swallowing. The aim of this multicenter open-label study was to characterize the serum pharmacokinetics of iron in non-pregnant women aged 23-45 years with iron deficiency anaemia (IDA) following single oral administration of 160 mg Tardyferon® under fasting conditions...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28723911/male-reproductive-system-and-spermatogenesis-of-limodromus-assimilis-paykull-1790
#2
Lea F Schubert, Stephanie Krüger, Gerald B Moritz, Veit Schubert
Based on advanced light and electron microscopy, we describe the male reproductive system and sperm development of Limodromus assimilis. The genital tract consists of pairs of uni-follicular testes, spermatic ducts with diverticula regions, seminal vesicles, accessory glands, an unpaired ejaculatory duct and an aedeagus containing an internal sac equipped with sclerotic scales. Based on their morphology, we draw conclusions about their functions. After spermatogenesis within the follicle, the spermatozoa become released from the sperm cysts...
2017: PloS One
https://www.readbyqxmd.com/read/28723838/transcatheter-pulmonary-valve-implantation-valve-technology-and-procedural-outcome
#3
Arash Salavitabar, Patrick Flynn, Ralf J Holzer
PURPOSE OF REVIEW: Procedural technique and short-term outcomes of transcatheter pulmonary valve implantation (TPVI) have been widely described. The purpose of this article is to provide an update on current valve technology, and to focus on recent data surrounding TPVI in the dilated right ventricular outflow tract (RVOT), hybrid interventions, significant outcomes, and procedural costs. RECENT FINDINGS: Transcatheter valve technology has expanded with current trials evaluating self-expandable valves that can be implanted in dilated RVOTs...
July 18, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28723805/acute-pancreatitis-induced-by-etoposide-lobaplatin-combination-chemotherapy-used-for-the-treatment-of-lung-cancer-a-case-report-and-literature-review
#4
Cheng-Liang Cao, Peng-Yu Duan, Wang-Jun Zhang, Le Li, Feng-Zhi Qu, Bei Sun, Gang Wang
RATIONALE: Drug-induced pancreatitis (DIP) is a rare type of pancreatitis that is not usually observed in the clinical practice. It is generally difficult to distinguish from acute pancreatitis (AP) induced by other causes. PATIENT CONCERNS: Here, we report a 62-year-old Chinese female patient with "small cell lung cancer" as the initial presentation. Because the patient could not bear the surgical treatment, the chemotherapy composed of lobaplatin and etoposide was performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723719/clinical-application-of-a-transurethral-holmium-laser-excision-of-exposed-polypropylene-mesh-at-lower-urinary-tract-single-surgeon-experience-with-long-term-follow-up
#5
Chan Ho Lee, Ja Yoon Ku, Kyoung Lee, Jeong Zoo Lee, Dong Gil Shin
PURPOSE: The aim of this study was to evaluate the clinical application of a transurethral holmium laser excision of exposed polypropylene mesh as an effective minimally invasive surgical approach in patients with lower urinary tract mesh erosion following the transvaginal placement of polypropylene mesh. METHODS: A retrospective analysis was conducted on the data of 22 patients with exposed polypropylene mesh in the lower urinary tract that was managed using the transurethral holmium laser technique...
July 19, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28723522/efficacy-and-safety-of-hexanic-lipidosterolic-extract-of-serenoa-repens-permixon-in-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Giacomo Novara, Gianluca Giannarini, Antonio Alcaraz, José-M Cózar-Olmo, Aurelien Descazeaud, Francesco Montorsi, Vincenzo Ficarra
CONTEXT: A recent Cochrane Collaboration meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of different extracts of Serenoa repens in relieving lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) concluded that these extracts were no more effective than placebo. However, among all Serenoa repens extracts, Permixon (Pierre Fabre Medicament, Paris, France) has the highest activity and the most accurate standards of drug preparation and extraction...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723511/fit-patient-with-nonmetastatic-castration-resistant-prostate-cancer-lower-urinary-tract-symptoms-and-severe-recurrent-haematuria
#7
Nuradh Joseph, Ananya Choudhury
For biochemical relapse in patients with nonmetastatic castration-resistant prostate cancer previously treated with androgen deprivation alone, external beam radiotherapy to the primary tumour and the pelvic lymph nodes is preferable to radical prostatectomy with lymphadenectomy.
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723510/case-presentation-fit-patient-with-nonmetastatic-castration-resistant-prostate-cancer-lower-urinary-tract-symptoms-and-severe-recurrent-haematuria
#8
R Jeroen A van Moorselaar
Patients with castration-resistant prostate cancer still need a urologist or radiation oncologist for treatment of local complications. Symptomatic progression will be reduced with treatment of the primary tumour.
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723501/antioxidants-is-it-simply-too-late-once-lower-urinary-tract-symptoms-are-established-editorial-to-european-urology-focus-2-3-2016-310-318
#9
EDITORIAL
Marcus J Drake
No abstract text is available yet for this article.
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723480/grey-zones-in-the-field-of-urinary-tract-infections
#10
T E Bjerklund Johansen, Gernot Bonkat, Tommaso Cai, Zafer Tandogdu, Florian Wagenlehner, Magnus Grabe
Urinary tract infections are a very common clinical problem with various knowledge gaps requiring urgent attention in areas including pathophysiology, diagnosis, antibiotic resistance, and prophylaxis. These grey zones preclude optimal management of urologic patients.
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723471/urinary-tract-infections-in-immunocompromised-patients-with-diabetes-chronic-kidney-disease-and-kidney-transplant
#11
REVIEW
Zafer Tandogdu, Tommaso Cai, Bela Koves, Florian Wagenlehner, Truls Erik Bjerklund-Johansen
CONTEXT: This paper provides a brief overview of urinary tract infections (UTIs) in immunocompromised patients from the perspective of a practicing urologist. OBJECTIVE: The primary objective was to provide an update on UTIs in immunocompromised patients. Diabetes mellitus (DM), chronic kidney disease, and kidney transplant (KT) are the most common clinical cases encountered by urologists. Diagnosis, management, and future research needs are summarised. EVIDENCE ACQUISITION: We conducted a nonsystematic review of the literature...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723463/the-global-prevalence-of-infections-in-urology-gpui-study-a-worldwide-surveillance-study-in-urology-patients
#12
Florian Wagenlehner, Zafer Tandogdu, Riccardo Bartoletti, Tommaso Cai, Mete Cek, Ekaterina Kulchavenya, Béla Köves, Kurt Naber, Tamara Perepanova, Peter Tenke, Björn Wullt, Florian Bogenhard, Truls Erik Bjerklund Johansen
The GPIU study is currently the only study registering health care-associated urogenital tract infections, especially in urology patients, in an ongoing surveillance protocol that can help to deliver data on adequate empirical antibiotic therapy in hospitalised urology patients according to guideline recommendations. The annual GPIU study will continue to be performed in November of each year under the URL http://gpiu.esiu.org/.
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723460/beware-of-bugs-hot-issues-in-urinary-tract-infections-and-inflammation
#13
EDITORIAL
Gianluca Giannarini, Tobias Klatte, James W Catto, Alberto Briganti
No abstract text is available yet for this article.
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723378/dietary-antioxidants-and-longitudinal-changes-in-lower-urinary-tract-symptoms-in-elderly-men-the-osteoporotic-fractures-in-men-study
#14
Kathleen F Holton, Lynn M Marshall, Jackilen Shannon, Jodi A Lapidus, James M Shikany, Douglas C Bauer, Elizabeth Barrett-Connor, J Kellogg Parsons
BACKGROUND: Antioxidants can potentially alter the progression of lower urinary tract symptoms (LUTS) through anti-inflammatory mechanisms. OBJECTIVE: To determine if dietary antioxidants are associated with reduced likelihood of LUTS progression or increased likelihood of LUTS remission in untreated elderly men. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of 1670 US men aged 65-100 yr. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Baseline variables included the American Urological Association Symptom Index, dietary intake assessed via a 69-item Block food frequency questionnaire (FFQ), demographics, lifestyle characteristics, quality of life (SF-12), and medication use...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723376/ureteral-involvement-is-associated-with-poor-prognosis-in-upper-urinary-tract-urothelial-carcinoma-patients-treated-by-nephroureterectomy-a-multicenter-database-study
#15
Yuma Waseda, Kazutaka Saito, Junichiro Ishioka, Yoh Matsuoka, Noboru Numao, Yasuhisa Fujii, Yasuyuki Sakai, Fumitaka Koga, Tetsuo Okuno, Chizuru Arisawa, Shigeyoshi Kamata, Katsuji Nagahama, Hitoshi Masuda, Junji Yonese, Yukio Kageyama, Akira Noro, Toshihiko Tsujii, Shinji Morimoto, Shuichi Gotoh, Kazunori Kihara
BACKGROUND: The prognostic significance of tumor location for patients with upper urinary tract urothelial carcinoma (UUT-UC) has been disputed. Several papers have reported that ureteral cancer is associated with worse prognosis. OBJECTIVE: To investigate the prognostic significance of the presence of ureteral tumors in UUT-UC patients who underwent radical nephroureterectomy (RNU). DESIGN, SETTING, AND PARTICIPANTS: In this multicenter retrospective study, 1068 eligible patients (median follow-up: 40 mo [interquartile range: 17-77 mo]) were divided into three groups based on tumor location: renal pelvic, ureteral, and both-regional (having both renal pelvic and ureteral tumors)...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723371/complications-of-transvaginal-mesh-for-pelvic-organ-prolapse-and-stress-urinary-incontinence-tips-for-prevention-recognition-and-management
#16
REVIEW
Susan MacDonald, Ryan Terlecki, Elisabetta Costantini, Gopal Badlani
CONTEXT: Mesh-related complications following transvaginal management of pelvic organ prolapse (POP) and/or stress urinary incontinence (SUI) have received significant attention in the last decade. OBJECTIVE: We sought to identify patient, product, and technical factors associated with an increased risk of complications after mesh-based transvaginal repair of anterior POP and SUI. In this review we clarify the different pattern of complications after POP and SUI repairs...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723230/retrograde-endourological-management-of-upper-urinary-tract-abnormalities-in-patients-with-ileal-conduit-urinary-diversion-a-dual-center-experience
#17
Louise Olson, Hywel Satherley, Paul Cleaveland, Bachar Zelhof, Max Mokete, Donald Neilson, Shalom Srirangam
INTRODUCTION: Patients with ileal conduit urinary diversions are at an increased risk of long-term upper urinary tract (UUT) complications, including anastomotic strictures, infections, and urolithiasis. The reconstructed urinary system poses challenges for endoscopic manipulation. We present and describe our dual-center experience in performing retrograde ureteroscopy to treat or diagnose UUT abnormalities in patients with ileal conduit incontinent diversion. PATIENT AND METHODS: We performed a retrospective analysis of medical records for all patients with previous urinary diversion who underwent retrograde ureteroscopic procedures via the ileal loop in our institutions over a 9 year period (between June 2007 and August 2016)...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28723186/ingestible-sensors
#18
Kourosh Kalantar-Zadeh, Nam Ha, Jian Zhen Ou, Kyle J Berean
Ingestible sensing capsules are fast emerging as a critical technology that has the ability to greatly impact health, nutrition, and clinical areas. These ingestible devices are noninvasive and hence are very attractive for customers. With widespread access to smart phones connected to the Internet, the data produced by this technology can be readily seen and reviewed online, and accessed by both users and physicians. The outputs provide invaluable information to reveal the state of gut health and disorders as well as the impact of food, medical supplements, and environmental changes on the gastrointestinal tract...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722661/dck-expression-a-potential-predictive-biomarker-in-the-adjuvant-gemcitabine-chemotherapy-for-biliary-tract-cancer-after-surgical-resection-results-from-a-phase-ii-study
#19
Sang Myung Woo, Kyong-Ah Yoon, Eun Kyung Hong, Weon Seo Park, Sung-Sik Han, Sang-Jae Park, Jungnam Joo, Eun Young Park, Ju Hee Lee, Yun-Hee Kim, Tae Hyun Kim, Woo Jin Lee
The role of adjuvant therapy following resection of biliary tract cancer (BTC) remains unclear. We therefore evaluated the feasibility and toxicity of adjuvant gemcitabine in patients with BTC. This clinical phase II trial was an open-label, single center, single-arm study. Within 8 weeks after gross complete resection of BTC, patients were started on intravenous infusions of gemcitabine 1000 mg/m2 over 30 min on days 1, 8, and 15 of every 28-day cycle. Intratumoral expression of cytidine deaminase (CDA), human equilibrative transporter-1 (hENT1), deoxycytidine kinase (dCK) and ribonucleotide reductase subunit 1 (RRM1) was measured by immunohistochemistry...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722615/assessing-the-short-term-global-health-experience-a-cross-sectional-study-of-demographics-socioeconomic-factors-and-disease-prevalence
#20
Olivia Geen, Allison Pumputis, Cristina Kochi, Andrew Costa, Karl Stobbe
Interest in short-term global health experiences to underserviced populations has grown rapidly in the last few decades. However, there remains very little research on what participants can expect to encounter. At the same time, it has been suggested that in order for physicians and workers to provide safe and effective care, volunteers should have a basic understanding of local culture, health systems, epidemiology, and socioeconomic needs of the community before arriving. Our objective was to add to the limited literature on what short-term global health trips can expect to encounter through a cross-sectional study of patient demographics, socioeconomic markers, and the prevalence of diseases encountered on a short-term medical service trip to Lima, Peru...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
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