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https://www.readbyqxmd.com/read/29334684/aberrant-connectivity-in-mild-cognitive-impairment-and-alzheimer-disease-revealed-by-multimodal-neuroimaging-data
#1
Qing Li, Xia Wu, Fufang Xie, Kewei Chen, Li Yao, Jiacai Zhang, Xiaojuan Guo, Rui Li
BACKGROUND: Making use of multimodal data simultaneously to understand the neural mechanism of mild cognitive impairment (MCI) has been in the focus nowadays. The simultaneous use of multimodal data can take advantage of each modality which may only provide the view of one specific aspect of the brain. OBJECTIVE: To this end, the present study used structural magnetic resonance imaging (sMRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and florbetapir PET to reveal the integrated brain network between MCI and normal controls (NCs)...
January 13, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29334461/enhanced-proton-loss-from-neutral-free-radicals-towards-carbon-centered-superacids
#2
John C Walton
Radical centers close to protons are known to enhance their dissociation. Investigation of the generality of this Radical Enhanced Deprotonation (RED-shift) phenomenon and the kinds of structures in which it operates are reported. The pKas for sulfinic, sulfonic, pentan-2,4-dione and Meldrum's acid species, with adjacent radicals centered on C-, N- and O-atoms, were computed by a DFT method from free energies of deprotonation. All series showed significant RED-shifts that increased with the electronegativity of the radical center...
January 15, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29334443/the-sanford-school-of-medicine-s-healthcare-quality-improvement-program-connecting-education-with-quality-improvement
#3
Shane Schellpfeffer, Mark Beard
No abstract text is available yet for this article.
December 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29334419/a-metallo-pro-drug-to-target-cu-ii-in-the-context-of-alzheimer-s-disease
#4
Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II)-based superoxide dismutase mimic ([MnII(L)]+, 1+) as a pro-drug candidate to target Cu(II) associated events, i.e. Cu(II)-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (Abeta) peptide aggregation. Complex 1+ is able to remove Cu(II) from Abeta, stop ROS and prevent alteration of Abeta aggregation as would do the corresponding free ligand LH. Using 1+ instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334403/soft-tissue-volume-gain-around-dental-implants-using-autogenous-subepithelial-connective-tissue-grafts-harvested-from-the-lateral-palate-or-tuberosity-area-a-randomized-controlled-clinical-study
#5
Ernest Rojo, Giorgio Stroppa, Ignacio Sanz-Martin, Oscar Gonzalez-Martín, Antonio Santos Alemany, José Nart
AIM: To compare the soft tissue volume gain (VG) around single tooth implants with subepithelial connective tissue graft (SCTG) from either the lateral palate (LP) or from the tuberosity area (TA). METHODS: 32 patients with 36 implants with buccal volume deficiencies were randomly assigned to receive SCTG from LP (control group/CG) or TA (test group/TG). Clinical parameters were recorded and volume gain was evaluated by STL image superimposition of 2 intraoral scans (baseline/BL and 3 months after surgery/FU-3)...
January 15, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29334369/dual-gene-activation-and-knockout-screen-reveals-directional-dependencies-in-genetic-networks
#6
Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu, Frank McCormick, Martin Kampmann, Michael T McManus
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcus aureus to carry out a dual screen in which one gene is activated while a second gene is deleted in the same cell. We analyze the quantitative effects of activation and knockout to calculate genetic interaction and directionality scores for each gene pair...
January 15, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29334297/perceptions-of-older-people-s-oral-health-care-among-nurses-working-in-geriatric-home-care
#7
Taru Aro, Marjo Laitala, Anna-Maija Syrjälä, Marja-Liisa Laitala, Jorma I Virtanen
OBJECTIVES: This study investigates nurses' self-reported experiences and perceptions of older people's oral health care using a qualitative method. METHODS: We interviewed 10 nurses working in geriatric home care who regularly visit and take care of older people in their homes. The interviews consisted of semi-structured questions. The interviews were then transcribed and analysed. RESULTS: All nurses were aware of the connection between oral health and general health, but more detailed knowledge about oral health was lacking and confidence in oral health care practices was limited...
January 15, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29334277/validation-of-dpoae-screening-conducted-by-village-health-workers-in-a-rural-community-with-real-time-click-evoked-tele-auditory-brainstem-response
#8
Vidya Ramkumar, C S Vanaja, James W Hall, K Selvakumar, Roopa Nagarajan
OBJECTIVE: This study assessed the validity of DPOAE screening conducted by village health workers (VHWs) in a rural community. Real-time click evoked tele-auditory brainstem response (tele-ABR) was used as the gold standard to establish validity. DESIGN: A cross-sectional design was utilised to compare the results of screening by VHWs to those obtained via tele-ABR. Study samples: One hundred and nineteen subjects (0 to 5 years) were selected randomly from a sample of 2880 infants and young children who received DPOAE screening by VHWs...
January 15, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29334274/an-overview-of-robotic-mechanical-devices-for-post-stroke-thumb-rehabilitation
#9
Marian Suarez-Escobar, Elizabeth Rendon-Velez
PURPOSE: This article aims to clarify the current state-of-the-art of robotic/mechanical devices for post-stroke thumb rehabilitation as well as the anatomical characteristics and motions of the thumb that are crucial for the development of any device that aims to support its motion. METHODS: A systematic literature search was conducted to identify robotic/mechanical devices for post-stroke thumb rehabilitation. Specific electronic databases and well-defined search terms and inclusion/exclusion criteria were used for such purpose...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29334227/using-a-television-documentary-to-prevent-suicide-in-men-and-boys
#10
Marisa Schlichthorst, Kylie King, Matthew Spittal, Lennart Reifels, Andrea Phelps, Jane Pirkis
OBJECTIVES: We investigated whether a documentary about masculinity and suicidality ( Man Up) could raise males' awareness of societal pressures to conform to masculine norms and influence their likelihood of connecting with their male friends and seeking help. METHODS: We conducted a repeat cross-sectional survey, posting versions of the survey online before and after Man Up was screened. RESULTS: 1287 male respondents completed the survey; 476 completed the pre-screening survey, 811 the post-screening survey (192 had not viewed Man Up, 619 had)...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29334035/neural-correlates-of-ostracism-in-transgender-persons-living-according-to-their-gender-identity-a-potential-risk-marker-for-psychopathology
#11
Sven C Mueller, Katrien Wierckx, Sara Boccadoro, Guy T'Sjoen
BACKGROUND: Stigmatization in society carries a high risk for development of psychopathology. Transgender persons are at particularly high risk for such stigmatization and social rejection by others. However, the neural correlates of ostracism in this group have not been captured. METHOD: Twenty transgender men (TM, female-to-male) and 19 transgender women (TW, male-to-female) already living in their gender identity and 20 cisgender men (CM) and 20 cisgender women (CW) completed a cyberball task assessing both exclusion and re-inclusion during functional magnetic resonance imaging (fMRI)...
January 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29333876/figuring-it-out-how-late-adolescent-and-young-adult-men-and-women-perceive-and-address-problems-in-sexual-functioning
#12
Lucia F O'Sullivan, Judith Wuest, E Sandra Byers
Although there are high rates of sexual problems and sexual dysfunction in adulthood (Mitchell et al., 2013), little is known about the circumstances under which problems are first experienced. A growing body of research addresses prevalence of problems in sexual functioning among adolescents and young adults, yet little is known about the meanings that young people give to these experiences or how they deal with them. We used content analysis of qualitative interviews with 53 heterosexual, sexually active Canadian adolescents (ages 18 to 21) to explore their perceptions of the sexual problems in functioning they had experienced and the strategies (if any) they used to address them over time...
January 15, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29333816/national-health-care-network-for-children-with-oral-clefts-organization-functioning-and-preliminary-outcomes
#13
Agustina Cassinelli, Nadia Pauselli, Agustina Piola, Claudia Martinelli, José L Alves de Azeved, María P Bidondo, Boris Groisman, Pablo Barbero, Rosa Liascovich, Ana Sala
INTRODUCTION: Oral clefts are major congenital anomalies that may affect the lip and/or palate, and that may also involve the nose and nostrils. In Argentina, their prevalence is approximately 15 per 10 000 births. In 2015, the Ministry of Health of Argentina created a national health care network for children with oral clefts in Argentina through the joint work with the National Registry of Congenital Anomalies (Red Nacional de Anomalías Congénitas, RENAC) (coordinating center for the national network) and the SUMAR Program...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333781/-research-progress-on-the-relationship-between-triggering-receptor-expressed-on-myeloid-cells-1-and-2-and-malignant-tumors
#14
Yang Yun, Wu Wuchao, Wu Yafei, Zhao Lei
Increasing scientific evidence supports the positive relationship between inflammation and cancer development. The immune response initiated by pattern recognition receptors is critical to triggering of tumor-associated inflammation. Triggering receptor expressed on myeloid cells (TREM) is an immunoglobulin of the super transmembrane glycoprotein family, which is mainly expressed on select groups of myeloid cells. The most important members of TREM comprise TREM-1 and TREM-2. Activation of TREM-1 and TREM-2 signaling is initiated upon binding of their ligands...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333767/-clinical-applications-of-periodontal-gingival-surgery-%C3%A2-autogenous-grafts
#15
Erjia Mao
The field of periodontics has become increasingly discussed and advanced in recent decades. The techniques of periodontal soft tissue grafts are among these advancements. The techniques have been used more and more clinically not only in periodontics, but also in the areas of dental implantology, aesthetics, and orthodontics. In this article, we discuss the clinical indications and the advantages and disadvantages of several autogenous tissue grafts (e.g. pedical grafts, free gingival graft, and subepithelial connective tissue graft)...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333752/workplace-design-for-the-australian-residential-aged-care-workforce
#16
Lucio Naccarella, Clare Newton, Alan Pert, Kurt Seemann, Ruth Williams, Kate Sellick, Briony Dow
OBJECTIVES: This research explored residential aged care (RAC) workplace design features that influence how RAC staff feel valued, productive, safe, like they belong and connected. A secondary aim was to validate emerging themes about RAC design features with stakeholders. METHODS: A multistage qualitative study was conducted in one RAC facility with 100 residents in outer metropolitan Melbourne: (i) photo-elicitation - photographs were used to prompt discussions with RAC staff; (ii) individual interviews with RAC directors; and (iii) validity testing with the advisory committee occurred...
January 14, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29333704/asian-horses-deepen-the-msy-phylogeny
#17
S Felkel, C Vogl, D Rigler, V Jagannathan, T Leeb, R Fries, M Neuditschko, S Rieder, B Velie, G Lindgren, C-J Rubin, C Schlötterer, T Rattei, G Brem, B Wallner
Humans have shaped the population history of the horse ever since domestication about 5500 years ago. Comparative analyses of the Y chromosome can illuminate the paternal origin of modern horse breeds. This may also reveal different breeding strategies that led to the formation of extant breeds. Recently, a horse Y-chromosomal phylogeny of modern horses based on 1.46 Mb of the male-specific Y (MSY) was generated. We extended this dataset with 52 samples from five European, two American and seven Asian breeds...
January 15, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29333646/examining-predictors-of-breakfast-skipping-and-breakfast-program-use-among-secondary-school-students-in-the-compass-study
#18
Katelyn M Godin, Karen A Patte, Scott T Leatherdale
BACKGROUND: Many Canadian schools offer breakfast programs; however, students' engagement in these programs is low, while breakfast skipping is highly prevalent among youth. This study examined whether the availability of breakfast programs supports adolescents' regular breakfast eating, and identified characteristics of breakfast skippers who are not using these programs. METHODS: Data from 30,771 secondary school students from Ontario and Alberta, Canada, participating in Year 3 (2014-2015) of the COMPASS study were used for descriptive and logistic regression analyses...
February 2018: Journal of School Health
https://www.readbyqxmd.com/read/29333621/characterization-of-mouse-neuro-urological-dynamics-in-a-novel-decerebrate-arterially-perfused-mouse-dapm-preparation
#19
Hiroki Ito, Marcus J Drake, Christopher H Fry, Anthony J Kanai, Anthony E Pickering
AIM: To develop the decerebrate arterially perfused mouse (DAPM) preparation, a novel voiding model of the lower urinary tract (LUT) that enables in vitro-like access with in vivo-like neural connectivity. METHODS: Adult male mice were decerebrated and arterially perfused with a carbogenated, Ringer's solution to establish the DAPM. To allow distinction between central and peripheral actions of interventions, experiments were conducted in both the DAPM and in a "pithed" DAPM which has no brainstem or spinal cord control...
January 15, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29333562/have-you-ever-googled-a-patient-or-been-friended-by-a-patient-social-media-intersects-the-practice-of-genetic-counseling
#20
NinaMarie F Omaggio, Maria J Baker, Laura J Conway
Patients and healthcare providers are becoming increasingly connected via social media, bringing new opportunities and challenges. Direct connection can occur between patients and providers using online tools such as Facebook and LinkedIn. In addition, providers can gather information about patients using a search engine such as Google, referred to as patient-targeted Googling (PTG). An online 54-item survey was used to gain information on (1) how and to what extent genetic counseling students and genetic counselors connect directly with patients via social media sites, and (2) gather information on providers using PTG...
January 15, 2018: Journal of Genetic Counseling
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