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https://www.readbyqxmd.com/read/29783270/reducing-alarm-fatigue-in-two-neonatal-intensive-care-units-through-a-quality-improvement-collaboration
#1
Kendall R Johnson, James I Hagadorn, David W Sink
OBJECTIVE:  To reduce nonactionable oximeter alarms by 80% without increasing time infants were hypoxemic (oxygen saturation [SpO2 ] ≤ 80%) or hyperoxemic (SpO2  > 95% while on supplemental oxygen). STUDY DESIGN:  In 2015, a multidisciplinary team at Connecticut Children's Medical Center initiated a quality improvement project to reduce nonactionable oximeter alarms in two referral neonatal intensive care units (NICUs). Changes made through improvement cycles included reduction of the low oximeter alarm limit for specific populations, increased low alarm delay, development of postmenstrual age-based alarm profiles, and updated bedside visual reminders...
May 21, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29783249/prognosis-of-ischaemic-heart-disease-in-patients-with-newly-diagnosed-dm-type-2-by-logistic-regression
#2
Alina Urbanovych, Halyna Suslyk
OBJECTIVE: Introduction: Diabetes Mellitus (DM) type 2 is an important medical and social problem all around the world. One of the most serious and widespread complications of DM type 2 is a damage to the cardiovascular system. The aim was to study the way of how to predict the IHD development in patients with the newly diagnosed DM type 2 by building a mathematical model with the help of statistical method, in particular, a logistic regression, which allows predicting the occurrence of IHD by the levels of proven biochemical and anthropometric indices...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783242/specific-nature-of-changes-in-main-immunohistochemical-parameters-of-neoangiogenesis-in-patients-with-psoriasis
#3
Iryna Ya Voznyak, Оrysya О Syzon, Marianna O Dashko
OBJECTIVE: Introduction: Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. Taking into consideration the data of scientific investigation, at present psoriasis is explained as genetically determined chronic multi factor polysystemic dermatosis. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization, depending on psoriasis form and severity of the course of pathological processes...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783234/-myocardial-bridge-as-the-only-cause-of-acute-coronary-syndrome-among-the-young-patients
#4
Liudmila O Miakinkova, Yurii V Teslenko, Irina V Tsyhanenko
OBJECTIVE: Introduction: Myocardial bridge is an inborn anomaly of coronary artery development, when a part of it is submerged in a myocard, which is pressing the coronary artery to a systola and restrains coronary blood circulation. Generally this feature of coronary blood circulation does not cause any clinical symptoms because the 85% of coronary blood stream of the left ventricle is provided by diastolic filling. Hemodynamic changes in atherosclerosis, tahicardie, hypertrophie of myocard are leading to the manifestation of clinical symptoms of ischemia...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783229/-morphological-characteristics-of-kidneys-connective-tissue-of-mature-fetuses-and-newborns-from-mothers-whose-pregnancy-was-complicated-by-preeclampsia-of-varying-degrees-of-severity
#5
Iryna V Sorokina, Mykhailo S Myroshnychenko, Nataliia V Kapustnyk, Tetyana O Khramova, Oksana V Dehtiarova, Svitlana I Danylchenko
OBJECTIVE: Introduction: The kidneys connective tissue condition in the antenatal period affects the formation of tissues and it changes with the development of various general pathological processes in this organ. The aim of the study was to identify the morphological features of kidneys connective tissue of fetuses and newborns from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity. PATIENTS AND METHODS: Materials and methods: The material of the study was the tissue of kidneys of mature fetuses and newborns from mothers with physiological pregnancy (28 cases), as well as from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity (78 cases)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783208/the-role-of-hydrogen-sulfide-in-the-progression-mechanisms-of-non-alcoholic-steatohepatitis-and-chronic-kidney-disease
#6
Oksana S Khukhlina, Igor V Gerush, Alona A Antoniv, Olha Ye Mandryk, Tamara G Kopchuk, Svitlana P Melnychuk, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The steady increase in the incidence of non-alcoholic steatohepatitis (NASH) on the background of obesity and chronic kidney disease (CKD) in people of working age in Ukraine. The aim: To establish the role of hydrogen sulfide in the mechanisms of mutual burden and progression of non-alcoholic steatohepatitis and chronic kidney disease in patients with obesity. PATIENTS AND METHODS: Materials and methods: 114 patients with NASH were examined on the background of obesity of І-ІІ degree, including: 52 patients with NASH (group 1) (without accompanying CKD), 62 patients with NASH with a comorbid CKD І-ІІ degree (group 2)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783104/school-climate-and-physical-adolescent-relationship-abuse-differences-by-sex-socioeconomic-status-and-bullying
#7
Sonia Jain, Alison K Cohen, Taylor Paglisotti, Malavika A Subramanyam, Alison Chopel, Elizabeth Miller
Little is known about the association between school climate and adolescent relationship abuse (ARA). We used 2011-2012 data from surveys of California public school students (in the United States of America) who were in a dating relationship in the last year (n = 112 378) to quantify the association between different school climate constructs and physical ARA. Fifty-two percent of students were female, and all students were in 9th or 11th grade (approximately ages 14-17). Over 11% of students reported experiencing physical ARA in the last year...
May 18, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29783076/disrupted-reward-and-cognitive-control-networks-contribute-to-anhedonia-in-depression
#8
Liang Gong, Cancan He, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xie
Neuroimaging studies have identified that anhedonia, a core feature of major depressive disorder (MDD), is associated with dysfunction in reward and cognitive control processing. However, it is still not clear how the reward network (β-network) and the cognitive control network (δ-network) are linked to biased anhedonia in MDD patients. Sixty-eight MDD patients and 64 cognitively normal (CN) subjects underwent a resting-state functional magnetic resonance imaging scan. A 2*2 ANCOVA analysis was used to explore the differences in the nucleus accumbens-based, voxelwise functional connectivity (FC) between the groups...
May 12, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29783028/thoracic-duct-embolization-a-survey-of-practice-patterns
#9
Samantha A Jayasinghe, Ravi N Srinivasa, Anthony N Hage, Joseph J Gemmete, Bill S Majdalany, Jeffrey Forris Beecham Chick
PURPOSE: To determine training, treatment techniques, outcomes, and practice patterns of practitioners performing thoracic duct embolization (TDE). MATERIALS AND METHODS: From September to October of 2017, a 34-question survey focusing on training, treatment techniques, outcomes, and practice patterns of TDE was distributed through the Open Forum using the Society of Interventional Radiology Connect website. 54 practitioners completed the entire survey. Percentages were calculated for answers to the questions...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29782994/structural-covariance-of-brain-region-volumes-is-associated-with-both-structural-connectivity-and-transcriptomic-similarity
#10
Yohan Yee, Darren J Fernandes, Leon French, Jacob Ellegood, Lindsay S Cahill, Dulcie A Vousden, Leigh Spencer Noakes, Jan Scholz, Matthijs C van Eede, Brian J Nieman, John G Sled, Jason P Lerch
An organizational pattern seen in the brain, termed structural covariance, is the statistical association of pairs of brain regions in their anatomical properties. These associations, measured across a population as covariances or correlations usually in cortical thickness or volume, are thought to reflect genetic and environmental underpinnings. Here, we examine the biological basis of structural volume covariance in the mouse brain. We first examined large scale associations between brain region volumes using an atlas-based approach that parcellated the entire mouse brain into 318 regions over which correlations in volume were assessed, for volumes obtained from 153 mouse brain images via high-resolution MRI...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29782993/generalized-recurrent-neural-network-accommodating-dynamic-causal-modeling-for-functional-mri-analysis
#11
Yuan Wang, Yao Wang, Yvonne W Lui
Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29782972/stat3-and-apoptosis-challenges-in-cancer
#12
REVIEW
Nazanin Fathi, Golnaz Rashdi, Simin Sharifi
Several studies have processed conceivable evidence for the vital role of Signal Transducer and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis. Therefore, one of the important factors in formation of cancer is STAT3 and for design of novel anticancer drugs is a suitable target. On the other hand, apoptosis pathway has a critical role in the cancers pathogenesis. Generally, increasing developments have been existed to expression, production, phosphorylation or activation of STAT3 in the effective or responsible cells of most of the cancers...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782849/seizure-modulation-by-sleep-and-sleep-state
#13
Carl W Bazil
Sleep is a dynamic process, during which the electrical rhythms of the brain orchestrate a complicated progression of changing frequencies, patterns and connectivity. Each stage of sleep is different electrophysiologically from wakefulness, and from other sleep stages. It should be no surprise, then, that the various sleep states influence the origin, suppression, and spread of seizures, and that different seizure types are affected in individual (and sometimes contradictory) ways. While much of the electrical symphony that occurs in both normal and epileptic brains is incompletely understood, at the basic level some interesting and often clinically important influences of the various sleep states have been identified...
May 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29782836/dancing-with-the-diva-hsp90-client-interactions
#14
REVIEW
Martina Radli, Stefan G D Rüdiger
The molecular chaperone Hsp90 is involved in the folding, maturation and degradation of a large number structurally and sequentially unrelated clients, often connected to serious diseases. Elucidating the principles of how Hsp90 recognises this large variety of substrates is essential for comprehending the mechanism of this chaperone machinery, as well as it is a prerequisite for the design of client specific drugs targeting Hsp90. Here, we discuss the recent progress in understanding the substrate recognition principles of Hsp90 and its implications for the role of Hsp90 in the lifecycle of (signalling) molecules...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782585/exploring-transformations-in-caribbean-indigenous-social-networks-through-visibility-studies-the-case-of-late-pre-colonial-landscapes-in-east-guadeloupe-french-west-indies
#15
Tom Brughmans, Maaike S de Waal, Corinne L Hofman, Ulrik Brandes
This paper presents a study of the visual properties of natural and Amerindian cultural landscapes in late pre-colonial East-Guadeloupe and of how these visual properties affected social interactions. Through a review of descriptive and formal visibility studies in Caribbean archaeology, it reveals that the ability of visual properties to affect past human behaviour is frequently evoked but the more complex of these hypotheses are rarely studied formally. To explore such complex hypotheses, the current study applies a range of techniques: total viewsheds, cumulative viewsheds, visual neighbourhood configurations and visibility networks...
2018: Journal of archaeological method and theory
https://www.readbyqxmd.com/read/29782584/including-traffic-jam-avoidance-in-an-agent-based-network-model
#16
Christian Hofer, Georg Jäger, Manfred Füllsack
Background: Understanding traffic is an important challenge in different scientific fields. While there are many approaches to constructing traffic models, most of them rely on origin-destination data and have difficulties when phenomena should be investigated that have an effect on the origin-destination matrix. Methods: A macroscopic traffic model is introduced that is novel in the sense that no origin-destination data are required as an input. This information is generated from mobility behavior data using a hybrid approach between agent-based modeling to find the origin and destination points of each vehicle and network techniques to find efficiently the routes most likely used to connect those points...
2018: Computational social networks
https://www.readbyqxmd.com/read/29782576/self-represented-witnessing-the-use-of-social-media-by-asylum-seekers-in-australia-s-offshore-immigration-detention-centres
#17
Maria Rae, Rosa Holman, Amy Nethery
The act of witnessing connects audiences with distant suffering. But what happens when bearing witness becomes severely restricted? External parties, including the mainstream news media, are constrained from accessing Australia's offshore immigration detention centres. The effect is that people seeking asylum are hidden from the public and excluded from national debates. Some detainees have adopted social media as a platform to communicate their stories of flight, and their experiences of immigration detention, to a wider audience...
May 2018: Media, culture, and society
https://www.readbyqxmd.com/read/29782536/fungal-type-carbohydrate-binding-modules-from-the-coccolithophore-emiliania-huxleyi-show-binding-affinity-to-cellulose-and-chitin
#18
Bart J M Rooijakkers, Martina S Ikonen, Markus B Linder
Six fungal-type cellulose binding domains were found in the genome of the coccolithophore Emiliania huxleyi and cloned and expressed in Escherichia coli. Sequence comparison indicate high similarity to fungal cellulose binding domains, raising the question of why these domains exist in coccolithophores. The proteins were tested for binding with cellulose and chitin as ligands, which resulted in the identification of two functional carbohydrate binding modules: EHUX2 and EHUX4. Compared to benchmark fungal cellulose binding domain Cel7A-CBM1 from Trichoderma reesei, these proteins showed slightly lower binding to birch and bacterial cellulose, but were more efficient chitin binders...
2018: PloS One
https://www.readbyqxmd.com/read/29782510/individual-differences-in-learning-correlate-with-modulation-of-brain-activity-induced-by-transcranial-direct-current-stimulation
#19
Brian Falcone, Atsushi Wada, Raja Parasuraman, Daniel E Callan
Transcranial direct current stimulation (tDCS) has been shown to enhance cognitive performance on a variety of tasks. It is hypothesized that tDCS enhances performance by affecting task related cortical excitability changes in networks underlying or connected to the site of stimulation facilitating long term potentiation. However, many recent studies have called into question the reliability and efficacy of tDCS to induce modulatory changes in brain activity. In this study, our goal is to investigate the individual differences in tDCS induced modulatory effects on brain activity related to the degree of enhancement in performance, providing insight into this lack of reliability...
2018: PloS One
https://www.readbyqxmd.com/read/29782368/tiny-moments-matter-promoting-professionalism-in-everyday-practice
#20
Elizabeth C Bernabeo, Benjamin Chesluk, Lorna Lynn
INTRODUCTION: Professionalism rests upon a number of individual, environmental, and societal level factors, leading to specific professional behavior in specific situations. Focusing on professional lapses to identify and remediate unprofessional physicians is incomplete. We explored professionalism in practicing internal medicine physicians in the context of everyday practice, to highlight how typical experiences contribute to positive, yet often unnoticed, professional behavior. METHODS: In-depth interviews were used to uncover 13 physicians' most meaningful experiences of professionalism...
May 16, 2018: Journal of Continuing Education in the Health Professions
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