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Onychomycosis laser

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https://www.readbyqxmd.com/read/27885523/a-review-of-the-mechanism-of-action-of-lasers-and-photodynamic-therapy-for-onychomycosis
#1
REVIEW
Anil Kumar Bhatta, Uma Keyal, Xiuli Wang, Emese Gellén
Onychomycosis is one of the most common diseases in the field of dermatology. It refers to the fungal infection of the nail plate or nail bed with high incidence in the general population. The available treatment options for onychomycosis have limited use due to side effects, drug interactions, and contraindications, which necessitates the application of an alternative treatment for onychomycosis. In the recent years, lasers and photodynamic therapy (PDT) have been recognized as alternative treatment options...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27858846/the-efficacy-of-fractional-carbon-dioxide-co2-laser-combined-with-luliconazole-1-cream-for-the-treatment-of-onychomycosis-a-randomized-controlled-trial
#2
Bing Rong Zhou, Yan Lu, Felicia Permatasari, He Huang, Jin Li, Juan Liu, Jia An Zhang, Dan Luo, Yang Xu
BACKGROUND: To evaluate the efficacy of fractional carbon dioxide (CO2) laser combined with luliconazole 1% cream for the treatment of onychomycosis and to compare it with that of fractional CO2 laser alone. METHODS: This was a randomized, parallel group, 2-arm, positive-controlled, single-center, superiority trial with a 1:2 allocation ratio. Sixty patients with clinical and mycological diagnosis of onychomycosis were enrolled from the Dermatology Department of the First Affiliated Hospital of Nanjing Medical University in Nanjing, China from March 2015 to May 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856773/real-world-efficacy-of-1064-nm-nd-yag-laser-for-the-treatment-of-onychomycosis
#3
REVIEW
Jason K Rivers, Brianne J Vestvik, Jonathan Berkowitz
BACKGROUND: Onychomycosis is a cosmetic and, at times, medical concern; therefore, effective and safe alternatives to treatment are needed. OBJECTIVE: To determine the efficacy of a 1064-nm Nd:YAG laser for the treatment of onychomycosis in a real-world setting. METHODS: A single-centre retrospective chart review was conducted between 2012 and 2013. One hundred consecutive patients with a culture- and/or potassium hydroxide-confirmed diagnosis of onychomycosis were treated at least twice...
November 16, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27815496/lasers-for-onychomycosis-current-status
#4
REVIEW
Aditya K Gupta, Kelly A Foley, Sarah G Versteeg
Many studies that have been recently published investigate the efficacy of laser treatment for onychomycosis. These studies support the current US Food and Drug Administration (FDA) approval of lasers for the 'temporary increase in clear nail'. Clear nail growth is an important treatment goal for patients; however, many do not realise that laser treatment is not a cure for onychomycosis. The current article briefly reviews why lasers may be theoretically effective in treating onychomycosis and critically reviews published laser studies for onychomycosis in light of the standards employed in drug trials...
November 4, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27686529/clinical-trials-of-lasers-for-toenail-onychomycosis-the-implications-of-new-regulatory-guidance
#5
Aditya K Gupta, Kelly A Foley, Deanne Daigle
BACKGROUND: Despite the fact that lasers are presently indicated for the cosmetic outcome "temporary increase in clear nail", these devices are increasingly used to treat onychomycosis and particularly in patients who are unwilling or unable to take oral antifungal medication. The US Food and Drug Administration (FDA) recently issued draft guidance for medical device trials for onychomycosis. OBJECTIVE: This review evaluates the quality of laser trials for onychomycosis and compares the design guidelines for medical devices and antifungal drugs...
August 10, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27521028/treating-onychomycosis-with-the-short-pulsed-1064-nm-nd-yag-laser-results-of-a-prospective-randomized-controlled-trial
#6
S Karsai, M Jäger, A Oesterhelt, C Weiss, S W Schneider, M Jünger, C Raulin
BACKGROUND: The role of the short-pulsed 1064-nm-Nd:YAG laser in treating onychomycosis has been the subject of controversial discussion ever since it received FDA approval in 2010. Research to date provides no valid conclusions supporting its use from an evidence-based perspective. OBJECTIVE: In this prospective randomized controlled pilot study, we analysed the effect of the short-pulsed 1064-nm-Nd:YAG laser on the rate of mycological remission and clinical improvement after excluding relevant confounders with regard to our previous studies...
August 13, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27503017/self-controlled-study-of-onychomycosis-treated-with-long-pulsed-nd-yag-1064-nm-laser-combined-with-itraconazole
#7
Yan Li, Jing Xu, Jun-Ying Zhao, Feng-Lin Zhuo
BACKGROUND: Onychomycosis is a fungal infection of the nail plate and subungual area. In this study, we examined the efficacy of laser treatment using self-controlled study programs involving a long-pulsed Nd:YAG 1064-nm laser combined with oral medication. METHODS: Self-controlled strategies were followed in this study. The patients received treatment with oral itraconazole in conjunction with long-pulsed Nd:YAG 1064-nm laser treatment at the nails of the unilateral limb once a week for a total of four times...
August 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27488125/tavaborole-efinaconazole-and-luliconazole-three-new-antimycotic-agents-for-the-treatment-of-dermatophytic-fungi
#8
Jacqueline Saunders, Kayla Maki, Renee Koski, S Eric Nybo
Fungal diseases of the nail bed (onychomycosis) and epidermis are recurrent illnesses in the elderly and immunocompromised patients, which have few efficacious treatment options. Current treatment options for onychomycosis are limited to topical agents, laser treatment, and oral antifungals. Previous generations of topical agents were not efficacious, owing to poor penetration of the nail bed. Oral antifungal drugs, such as itraconazole, terbinafine, and fluconazole, not only give better response rates but also inhibit a host of CYP450 enzymes...
August 3, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27465251/a-clinical-review-of-laser-and-light-therapy-for-nail-psoriasis-and-onychomycosis
#9
Lauren E Wiznia, Nicola A Quatrano, Euphemia W Mu, Evan A Rieder
BACKGROUND: There are considerable emerging data in the use of lasers and lights to treat onychomycosis and psoriasis of the nail subunit. OBJECTIVE: We aimed to review all of the medical literature on laser therapy of nail psoriasis and onychomycosis published since 1992. METHODS AND MATERIALS: We performed a PubMed literature search using the search terms "nail," "laser therapy," "laser surgery," "light," with search terms "psoriasis" and "onychomycosis...
July 25, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27402466/a-randomised-comparative-study-of-1064-nm-neodymium-doped-yttrium-aluminium-garnet-nd-yag-laser-and-topical-antifungal-treatment-of-onychomycosis
#10
Tae In Kim, Min Kyung Shin, Ki-Heon Jeong, Dong Hye Suh, Sang Jun Lee, In-Hwan Oh, Mu-Hyoung Lee
Conventional treatments for onychomycosis include oral and topical antifungal agents. Although Nd:YAG laser has been reported to be effective, controlled studies combined or compared with conventional treatments are needed. To evaluate the efficacy of 1064 nm Nd:YAG laser for onychomycosis and compare outcomes with those of topical antifungal treatment and combination therapy. Patients were randomly divided into three groups: Laser (L); laser with topical antifungal therapy (L + T); and topical antifungal treatment (T)...
July 12, 2016: Mycoses
https://www.readbyqxmd.com/read/27339057/combination-therapy-for-onychomycosis-using-a-fractional-2940-nm-er-yag-laser-and-5%C3%A2-amorolfine-lacquer
#11
Jing Zhang, Sha Lu, Huaiqiu Huang, Xiqing Li, Wenying Cai, Jianchi Ma, Liyan Xi
Onychomycosis remains difficult to cure by traditional methods. The aim of this study was to evaluate the efficacy of combination therapy with a fractional erbium yttrium aluminum garnet (Er:YAG) laser and 5 % amorolfine lacquer on onychomycosis. Nine patients with bilateral nails affected by distal and lateral subungual onychomycosis were included. The bilateral nails of each patient were divided into two groups. The 20 affected nails on one side of each patient as group 1 were treated with a fractional Er:YAG laser once a week and 5 % amorolfine lacquer twice weekly, while the 20 nails on the symmetrical side of each patient as group 2 were treated with amorolfine lacquer only...
September 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27274650/the-efficacy-and-prognostic-factors-for-long-pulse-neodymium-yttrium-aluminum-garnet-laser-treatment-on-onychomycosis-a-pilot-study
#12
Sha Lu, Jing Zhang, Yuheng Liang, Xiqing Li, Wenying Cai, Liyan Xi
No abstract text is available yet for this article.
June 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27222187/-efficacy-and-safety-of-long-pulse-1064-nm-nd-yag-laser-for-treatment-of-onychomycosis-of-the-toenails
#13
Ye-Mei Yang, Si-Tong Zhou, Yong-Xuan Hu, Zu-Hao Mao, Zhong Wu, Xue Han, Kang-Xing Liu, Shi-Yun Hunag, Yan-Qing Hu, Yan Lu, Xian-Yi Zhou
OBJECTIVE: To evaluate the efficacy and safety of long pulse 1064 nm Nd:YAG laser therapy in the treatment of onychomycosis of the toenails. METHODS: A total of 104 patients with onychomycosis (461 toenails) were divided by age into ≥60 years group and <60 years group, and each group was further divided into subgroups according to Scoring Clinical Index of Onychomycosis (SCIO) scoring and the location of the compromised toenails. All the toenails were treated with 10 to12 sessions of long pulse 1064 nm Nd:YAG laser therapy at the interval of 1 week...
May 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27138036/terbinafine-hydrochloride-trans-ungual-delivery-via-nanovesicular-systems-in-vitro-characterization-and-ex-vivo-evaluation
#14
Noha Ibrahim Elsherif, Rehab Nabil Shamma, Ghada Abdelbary
Treating a nail infection like onychomycosis is challenging as the human nail plate acts as a formidable barrier against all drug permeation. Available oral and topical treatments have several setbacks. Terbinafine hydrochloride (TBH), belonging to the allylamine class, is mainly used for treatment of onychomycosis. This study aims to formulate TBH in a nanobased spanlastic vesicular carrier that enables and enhances the drug delivery through the nail. The nanovesicles were formulated by ethanol injection method, using either Span® 60 or Span® 65, together with Tween 80 or sodium deoxycholate as an edge activator...
May 2, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27031556/diagnosis-and-management-of-onychomycosis-perspectives-from-a-joint-podiatric-medicine-dermatology-roundtable
#15
Tracey C Vlahovic, Warren S Joseph, Richard K Scher, Antonella Tosti, Jesse Plasencia, David M Pariser, Bryan C Markinson
Onychomycosis is a fungal infection, and, as such, one of the goals of treatment should be eradication of the infective agent. Despite this, in contrast to dermatologists, many podiatric physicians do not include antifungals in their onychomycosis treatment plans. Before initiating treatment, confirmation of mycologic status via laboratory testing (eg, microscopy with potassium hydroxide preparation, histopathology with periodic acid-Schiff staining, fungal culture, and polymerase chain reaction) is important; however, more podiatric physicians rely solely on clinical signs than do dermatologists...
March 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27010770/the-effectiveness-of-1-064-nm-long-pulsed-nd-yag-laser-in-the-treatment-of-severe-onychomycosis
#16
Min Seok Kim, Ji Yun Jung, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
INTRODUCTION: Severe onychomycosis in the elderly is a common condition and generally difficult to treat. Long-pulsed Nd:YAG (LPNY) laser has been found to be useful in the treatment of onychomycosis. We sought to evaluate the effectiveness of 1,064-nm LPNY laser in the treatment of severe onychomycosis. MATERIALS AND METHODS: Forty nails in 13 patients with severe onychomycosis were divided into two groups. Each group received eight treatment sessions at one-week intervals with 1,064-nm LPNY laser...
October 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/26953542/laser-therapies-for-onychomycosis-critical-evaluation-of-methods-and-effectiveness
#17
REVIEW
W Francuzik, K Fritz, C Salavastru
The number of medical devices designed specifically to treat onychomycosis has recently increased, although their mechanism of action is not clear. We evaluated available laser therapies for onychomycosis by reviewing the existing literature. Twenty-two reports, published in peer-reviewed journals and as white papers out of 926 initial search results conveyed enough details to be included in this study. In most cases, the methodology of the trials described in the papers we reviewed was not comprehensive and the reporting of outcomes was not unified...
June 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26936299/translational-medicine-in-the-field-of-ablative-fractional-laser-afxl-assisted-drug-delivery-a-critical-review-from-basics-to-current-clinical-status
#18
REVIEW
Merete Haedersdal, Andrés M Erlendsson, Uwe Paasch, R Rox Anderson
BACKGROUND: Ablative fractional lasers enhance uptake of topical therapeutics and the concept of fractional laser-assisted drug delivery has now been taken into clinical practice. OBJECTIVES: We systematically reviewed preclinical data and clinical evidence for fractional lasers to enhance drug uptake and improve clinical efficacy. METHODS: We searched PubMed and Embase databases; 34 articles met the inclusion criteria. Studies were categorized into experimental preclinical studies and clinical trials, the latter graded according to level of evidence...
May 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26874820/fractional-carbon-dioxide-co2-laser-assisted-topical-therapy-for-the-treatment-of-onychomycosis
#19
Anil Kumar Bhatta, Uma Keyal, Xin Huang, Jing Jun Zhao
BACKGROUND: Inability of topical medications to penetrate via nail plate brings a great challenge to clinicians in treating onychomycosis. Furthermore, oral medications are not appropriate for all patients because of drug interactions, adverse effects, and contraindications. OBJECTIVE: We sought to evaluate the clinical efficacy of fractional carbon-dioxide laser-assisted topical therapy for onychomycosis. METHODS: In total, 75 patients with 356 onychomycotic nails confirmed by mycologic examination were included in this study...
May 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26809447/how-effective-is-efinaconazole-in-the-management-of-onychomycosis
#20
Aditya K Gupta, Maria Cernea
INTRODUCTION: Onychomycosis is a fungal nail infection that is difficult to treat due to poor accessibility of drugs into the nail plate. Although oral antifungals can reach the nail apparatus more readily, these therapies may not be suitable or desirable for some patients (e.g., multiple medications or immunocompromised). Efinaconazole 10% solution is a new topical antifungal recently approved and sold in Canada, the United States and Japan for the treatment of mild-to-moderate toenail onychomycosis...
2016: Expert Opinion on Pharmacotherapy
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