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Volume guarantee ventilation newborn

Frank Caminita, Marie van der Merwe, Brittany Hance, Ramesh Krishnan, Sarah Miller, Karyl Buddington, Randal K Buddington
Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia remain the leading causes of preterm infant morbidity, mortality, and lifelong disability. Research to improve outcomes requires translational large animal models for RDS. Preterm pigs delivered by caesarian section at gestation days (GD) 98, 100, 102, and 104 were provided 24 h of neonatal intensive care, monitoring (pulse oximetry, blood gases, serum biomarkers, radiography), and nutritional support, with or without intubation and mechanical ventilation (MV; pressure control ventilation with volume guarantee)...
January 15, 2015: American Journal of Physiology. Lung Cellular and Molecular Physiology
Judith L Hough, Andrew D Shearman, Helen Liley, Caroline A Grant, Andreas Schibler
AIMS: Although suctioning is a standard airway maintenance procedure, there are significant associated risks, such as loss of lung volume due to high negative suction pressures. This study aims to assess the extent and duration of change in end-expiratory level (EEL) resulting from endotracheal tube (ETT) suction and to examine the relationship between EEL and regional lung ventilation in ventilated preterm infants with respiratory distress syndrome. METHODS: A prospective observational clinical study of the effect of ETT suction on 20 non-muscle-relaxed preterm infants with respiratory distress syndrome (RDS) on conventional mechanical ventilation was conducted in a neonatal intensive care unit...
November 2014: Journal of Paediatrics and Child Health
Martin Keszler, Kabir Abubakar
BACKGROUND: Surgical closure of patent ductus arteriosus (PDA) is associated with adverse outcomes. Surgical exposure requires retraction of the lung, resulting in decreased aeration and compliance. Optimal respiratory support for PDA surgery is unknown. Experience with volume guarantee (VG) ventilation at our institution led us to hypothesize that surgery would be better tolerated with automatic adjustment of pressure by VG to maintain tidal volume (VT) during retraction. OBJECTIVE: The objective of this study was to describe ventilator support, VT, and oxygenation of infants supported with VG during PDA surgery...
January 2015: American Journal of Perinatology
Yoshio Sakurai, Masanori Tamura
No abstract text is available yet for this article.
March 2014: Pediatric Critical Care Medicine
Aydin Erdemir, Zelal Kahramaner, Ebru Turkoglu, Hese Cosar, Sumer Sutcuoglu, Esra Arun Ozer
OBJECTIVE: To compare the effects and short-term outcomes of pressure support ventilation with volume guarantee versus synchronized intermittent mandatory ventilation in the weaning phase of very low-birth weight infants with respiratory distress syndrome. DESIGN: Randomized controlled prospective study. SETTING: Tertiary care neonatal unit. PATIENTS: A total of 60 premature infants who were less than 33 weeks' gestation and/or less than 1,500 g birth weight and received mechanical ventilation because of respiratory distress syndrome were studied...
March 2014: Pediatric Critical Care Medicine
Clarissa Gutierrez Carvalho, Rita C Silveira, Renato Soibelmann Procianoy
In preterm infants, the need for intubation and mechanical ventilation is associated with ventilator-induced lung injuries and subsequent bronchopulmonary dysplasia. The aim of the present review was to improve the understanding of the mechanisms of injury that involve cytokine-mediated inflammation to contribute to the development of new preventive strategies. Relevant articles were retrieved from the PubMed database using the search terms "ventilator-induced lung injury preterm", "continuous positive airway pressure", "preterm", and "bronchopulmonary dysplasia"...
October 2013: Revista Brasileira de Terapia Intensiva
S Shah, A Kaul
AIM: The aim of our study was to quantify arterial carbon dioxide levels (PaCO2) achieved by ventilating extremely preterm neonates in volume guarantee mode targeting tidal volumes of approximately 4 ml/kg. METHODS: We performed a prospective trial on preterm infants with gestational age ≤28 weeks, birth-weight ≤1000 grams, postnatal age <48 hours and are supported by mechanical ventilation. All infants were ventilated using volume guarantee plus synchronized intermittent positive pressure ventilation (SIPPV + VG mode)...
January 1, 2013: Journal of Neonatal-perinatal Medicine
Gianluca Lista, Francesca Castoldi, Silvia Bianchi, Enrica Lupo, Francesco Cavigioli, Andrea Farolfi, Chiara Bersanini, Emiliana Ferrerio
OBJECTIVE: To investigate respiratory health and lung function in school-aged children without broncho-pulmonary dysplasia (BPD), who were very low birth weight (VLBWi) and randomized at birth to high frequency oscillatory ventilation (HFOV) or volume guarantee (VG) ventilation for severe respiratory distress syndrome (RDS). METHODS: In this observational study, 7-y-old ex-preterm infants with severe RDS, randomly assigned at birth to receive assisted/control ventilation + VG (Vt = 5 mL/kg, PEEP = 5 cmH2O)(VG group; mean GA 27 ± 2 wk; mean BW 1086 ± 158 g) or HFOV (HFOV group; mean GA: 27 ± 2; mean BW: 1090 ± 139 g) (both groups were ventilated with Drager Babylog 8000 plus) were recalled...
March 2014: Indian Journal of Pediatrics
Andrea Dotta, Anna Portanova, Natalia Bianchi, Marta Ciofi Degli Atti, Rinaldo Zanini, Massimiliano Raponi
UNLABELLED: Accreditation or certification of Health Care Providers is a crucial tool to improve health care quality, and to promote excellence. Excellent healthcare should have the following six characteristics: Safe, Effective, Person-centred, Timely, Efficient, Equitable. Safety in health care should consider the analysis and reduction of medical systematic errors and their related patients' harm. In 1999 the U.S. Institute of Medicine defined medical errors as the failure of a planned action to be completed as intended or the use of a wrong plan to achieve an aim...
March 2013: Journal of Maternal-fetal & Neonatal Medicine
G M Sant'Anna, M Keszler
Mechanical ventilation is a resource-intensive complex medical intervention associated with high morbidity. Considerable practice style variation exists in most hospitals and is not only confusing for parents, but the lack of consistently high standard of optimal ventilation deprives some infants of the benefits of state-of-the-art care. Developing a unit protocol for mechanical ventilation requires exhaustive research, inclusion of all stake-holders, thoughtful protocol development and careful implementation after a thorough educational process, followed by monitoring...
December 2012: Early Human Development
Sirin Guven, Senol Bozdag, Hulya Saner, Merih Cetinkaya, Ahmet Sami Yazar, Muferet Erguven
BACKGROUND: Volume guaranteed (VG) synchronized intermittent mandatory ventilation (SIMV) is a novel mode of SIMV that provides automatic adjustment of the peak inspiratory pressure for ensuring a minimum set tidal volume and there are limited data about the effects of VG ventilation on short term neonatal outcomes in preterm infants with respiratory distress syndrome (RDS). OBJECTIVE: The main objective of this study was to evaluate the effect of VG ventilation on duration of ventilation and total supplemental oxygen...
March 2013: Journal of Maternal-fetal & Neonatal Medicine
Luigi Gagliardi, Paolo Tagliabue, Roberto Bellù, Carlo Corchia, Fabio Mosca, Rinaldo Zanini
BACKGROUND: Respiratory support in very preterm infants is often a life-saving procedure and several techniques are available. There is lack of data on the current use of these techniques. METHODS AND AIM: We analyzed a cohort of infants <30 weeks gestation or < 1501 g birth weight, enrolled in the Italian Neonatal Network in 2009 and 2010 (n = 8297, mean gestation = 29.3 weeks, mean birth weight = 1089 g) to ascertain the use of several techniques. We also conducted a questionnaire survey of all neonatal units adhering to the Italian Neonatal Network, inquiring about preferred methods of respiratory support...
October 2012: Journal of Maternal-fetal & Neonatal Medicine
Francesc Botet, Josep Figueras-Aloy, Xavier Miracle-Echegoyen, José Manuel Rodríguez-Miguélez, Maria Dolors Salvia-Roiges, Xavier Carbonell-Estrany
OBJECTIVE: The aim of this study was to analyze the evolution from 1997 to 2009 of survival without significant (moderate and severe) bronchopulmonary dysplasia (SWsBPD) in extremely-low-birth-weight (ELBW) infants and to determine the influence of changes in resuscitation, nutrition and mechanical ventilation on the survival rate. STUDY DESIGN: In this study, 415 premature infants with birth weights below 1000 g (ELBW) were divided into three chronological subgroups: 1997 to 2000 (n = 65), 2001 to 2005 (n = 178) and 2006 to 2009 (n = 172)...
2012: BMC Pediatrics
Nuray Duman, Funda Tuzun, Sumer Sutcuoglu, Cemile Didem Yesilirmak, Abdullah Kumral, Hasan Ozkan
PURPOSE: The aim of this randomized controlled trial was to assess whether the addition of volume guarantee (VG) to triggered ventilation decreases the duration of ventilation in very low birth weight (VLBW) infants with respiratory distress syndrome (RDS). METHODS: Infants were randomized into two groups to initially receive either assist/control (A/C) or A/C plus VG ventilation and then weaned with synchronized intermittent mandatory ventilation (SIMV) or SIMV plus VG...
August 2012: Intensive Care Medicine
Martin Keszler, Maria Brugada Montaner, Kabir Abubakar
OBJECTIVE: The authors previously showed that 48% of infants <800 g were ventilated with tidal volume (VT) < dead space (DS) using volume guarantee (VG) ventilation. Here, The authors sought to confirm those findings under the rigorous conditions of a bench study. DESIGN AND METHODS: The authors measured the time to wash out CO2 from a 45-ml test lung using end-tidal CO(2) monitor (ETCO(2)). The test lung was filled with 100% CO(2), then ventilated using VG at VT ranging from DS+2 ml to DS-1...
May 2012: Archives of Disease in Childhood. Fetal and Neonatal Edition
Cui-Qing Liu, Ze Cui, Yao-Fang Xia, Li Ma, Li-Li Fan
OBJECTIVE: To evaluate the efficacy of targeted tidal volume ventilation in the treatment of severe neonatal respiratory distress syndrome (RDS). METHODS: Eighty-four neonates with severe RDS between June 2008 and January 2010 were randomly assigned to 3 groups according to the ventilation mode: synchronized intermittent positive pressure ventilation plus volume guarantee (SIPPV+VG; n=31), high frequency oscillation ventilation (HFOV; n=23) and intermittent mandatory ventilation (IMV; n=30)...
September 2011: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
F Racca, M Bonati, L Del Sorbo, G Berta, M Sequi, E C Capello, A Wolfler, I Salvo, E Bignamini, G Ottonello, R Cutrera, P Biban, F Benini, V M Ranieri
BACKGROUND: To date, few studies have been published regarding the number of children in Italy who require long-term mechanical ventilation (LTV) and their underlying diagnoses, ventilatory needs and hospital discharge rate. METHODS: A preliminary national postal survey was conducted and identified 535 children from 57 centers. Detailed data were then obtained for 378 children from 30 centers. RESULTS: The estimated prevalence in Italy of this population was 4...
September 2011: Minerva Anestesiologica
C Klingenberg, K I Wheeler, P G Davis, C J Morley
A recent systematic review and meta-analysis shows that volume-targeted ventilation (VTV) compared with pressure-limited ventilation (PLV) reduce death and bronchopulmonary dysplasia, pneumothorax, hypocarbia and severe cranial ultrasound abnormalities. In this paper, we present published research and our experience with volume guarantee (VG) ventilation, a VTV mode available on the Dräger Babylog 8000plus and VN500 ventilators. The VG algorithm measures the expired tidal volume (V(T)) for each inflation and adjusts the peak inflating pressure for the next inflation to deliver a V(T) set by the clinician...
September 2011: Journal of Perinatology: Official Journal of the California Perinatal Association
K I Wheeler, C J Morley, S B Hooper, P G Davis
OBJECTIVE: The objective of this study is to compare the effects of back-up ventilation rates (BURs) on triggered inflations and patient cardiorespiratory stability during assist-control/volume guarantee ventilation (AC/VG). STUDY DESIGN: This study is a randomized crossover trial conducted in a neonatal unit in an Australian tertiary NICU. In all, 26 stable preterm infants on AC/VG ventilation were studied at BUR settings of 30, 40 and 50 min(-1). Inflation rate, triggering and cardiorespiratory measures of patient stability were compared during 20 min epochs with 10 min washout periods...
February 2012: Journal of Perinatology: Official Journal of the California Perinatal Association
O A Kriakvina, V A Grebennikov, L E Tsypin, N N Volodin
Mechanical ventilation with guaranteed volumes combines advantages of time-cyclic ventilation with limitation of pressure and constant flow, with volume control ventilation. This symbiosis allows to choose the optimal, stable breathing volume of the newborn, while maintaining pressure control. The review presents the principles of work, the main advantages and limitations of ventilation systems with the guaranteed volumes, as well as results and analysis of studies.
January 2011: Anesteziologiia i Reanimatologiia
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