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https://www.readbyqxmd.com/read/28339746/in-vitro-cytotoxic-and-ace-inhibitory-activities-of-promod-278p-hydrolysate-of-ovotransferrin-from-chicken-egg-white
#1
S H Moon, J H Lee, J H Kim, H-D Paik, D U Ahn
Peptides released from egg proteins via enzymatic hydrolysis show various bioactivities such as antimicrobial, antioxidant, antihypertensive, and immunomodulatory properties. The objective of this study was to investigate the cytotoxic and Angiotensin Converting Enzyme (ACE)-inhibitory activities of ovotransferrin and its promod 278P enzyme hydrolysate. Ovotransferrin from egg white was hydrolyzed using promod 278P at 45°C for 3 hours. Using the MTT assay, the cytotoxicity of ovotransferrin and promod 278P hydrolysate of ovotransferrin were evaluated in human cancer cell lines of various tissue origins...
February 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/28335507/hydroxytyrosol-in-the-prevention-of-the-metabolic-syndrome-and-related-disorders
#2
REVIEW
Julien Peyrol, Catherine Riva, Marie Josèphe Amiot
Virgin olive oil (VOO) constitutes the main source of fat in the Mediterranean diet. VOO is rich in oleic acid, displaying health-promoting properties, but also contains minor bioactive components, especially phenolic compounds. Hydroxytyrosol (HT), the main polyphenol of olive oil, has been reported to be the most bioactive component. This review aims to compile the results of clinical, animal and cell culture studies evaluating the effects of HT on the features of Metabolic Syndrome (MetS) (body weight/adiposity, dyslipidemia, hypertension, and hyperglycemia/insulin resistance) and associated complications (oxidative stress and inflammation)...
March 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28335427/laxative-effects-of-total-diterpenoids-extracted-from-the-roots-of-euphorbia-pekinensis-are-attributable-to-alterations-of-aquaporins-in-the-colon
#3
Kuilong Wang, Lian Liu, Jianyu Huang, Hongli Yu, Hao Wu, Yu Duan, Xiaobing Cui, Xingde Zhang, Liping Liu, Wei Wang
This study was designed to evaluate the toxic effects of total diterpenoids extracted from the roots of Euphorbia pekinensis (TDEP) on the mouse colon and to clarify the mechanism. Dried powdered roots of E. pekinensis were extracted with chloroform, and then the extract (6.7 g) was subjected to column chromatography and preparative TLC, giving TDEP. Using the HPLC-DAD method, the purity of TDEP was determined as 85.26%. Mice were orally administered with TDEP (3.942, 19.71 and 39.42 mg/kg), after which fecal water content and colon water content were examined...
March 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28334024/opposite-effects-of-5-ht-akh-and-octopamine-on-the-crop-contractions-in-adult-drosophila-melanogaster-evidence-of-a-double-brain-gut-serotonergic-circuitry
#4
Paolo Solari, Nicholas Rivelli, Francescaelena De Rose, Lorenzo Picciau, Ludovico Murru, John G Stoffolano, Anna Liscia
This study showed that in adult Drosophila melanogaster, the type of sugar-either present within the crop lumen or in the bathing solution of the crop-had no effect on crop muscle contraction. What is important, however, is the volume within the crop lumen. Electrophysiological recordings demonstrated that exogenous applications of serotonin on crop muscles increases both the amplitude and the frequency of crop contraction rate, while adipokinetic hormone mainly enhances the crop contraction frequency. Conversely, octopamine virtually silenced the overall crop activity...
2017: PloS One
https://www.readbyqxmd.com/read/28332414/determination-of-mycotoxins-in-biscuits-dried-fruits-and-fruit-jams-assessment-of-human-exposure
#5
Biljana Škrbić, Igor Antić, Jelena Cvejanov
A reliable, fast and simple method using UHPLC-MS/MS was developed for the determination of aflatoxins B1 (AFB1), G1 (AFG1), B2 (AFB2) and G2 (AFg2), ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEA), HT-2 toxin and T-2 toxin in crude extracts of biscuits with fruit filling, cookies, dried fruits and fruit jams. The method was successfully demonstrated on 39 samples of biscuits with fruit filling, 34 cookies, 14 dried fruits and 10 fruit jams. The mycotoxins detected in biscuits samples were ZEA, OTA, T-2, and AFB1 with average concentration of positive samples of 2...
March 23, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28332358/perceptions-of-postmenopausal-symptoms-and-treatment-options-among-middle-aged-korean-women
#6
Min Kyoung Kim, Seok Kyo Seo, Hee Dong Chae, Kyung Joo Hwang, Tak Kim, Byung Koo Yoon, Byung Seok Lee
PURPOSE: To investigate the perceptions of postmenopausal symptoms and treatment options among middle-aged Korean women. MATERIALS AND METHODS: This cross-sectional study included 2330 Korean women. The women were administered a structured questionnaire to collect sociodemographic data and information regarding menopause and its treatment. RESULTS: More than half (65%) of the participants perceived menopause as a disease, and 66.8% knew hormone therapy (HT) is available for menopausal symptom treatment...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332205/evidence-that-5-ht-stimulates-intracellular-ca-2-signalling-and-activates-pannexin-1-currents-in-type-ii-cells-of-the-rat-carotid-body
#7
Sindhubarathi Murali, Min Zhang, Colin A Nurse
Carotid body (CB) chemoreceptor (type I) cells can synthesize and release 5-hydroxytryptamine (5-HT) and increased autocrine-paracrine 5-HT2 receptor signalling contributes to sensory long-term facilitation during chronic intermittent hypoxia (CIH). However, recent studies suggest that adjacent glial-like type II cells can respond to CB paracrine signals by elevating intracellular calcium (Δ[Ca(2+) ]i ) and activating carbenoxolone-sensitive, ATP-permeable, pannexin-1 (Panx-1)-like channels. Here, using dissociated rat CB cultures, we found that 5-HT induced Δ[Ca(2+) ]i responses in a subpopulation of type I cells, and in most (∼67%) type II cells identified by their sensitivity to the P2Y2 receptor agonist, UTP...
March 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28331523/helicteric-acid-oleanic-acid-and-betulinic-acid-three-triterpenes-from-helicteres-angustifolia-l-inhibit-proliferation-and-induce-apoptosis-in-ht-29-colorectal-cancer-cells-via-suppressing-nf-%C3%AE%C2%BAb-and-stat3-signaling
#8
Dan Su, Yu-Qiao Gao, Wei-Bo Dai, Ying Hu, Yan-Fen Wu, Quan-Xi Mei
Colorectal cancer (CRC) is one of the most common malignancies and most frequent cause of cancer death worldwide. The activation of both NF-κB and STAT3 signaling and the crosstalk between them play an important role in colorectal tumor. Helicteres angustifolia L. is a type of commonly used Chinese medicinal herb and possesses a wide variety of biological activities. In the present study, we investigate the effects of three triterpenes from H. angustifolia (HT) such as helicteric acid (HA), oleanic acid (OA), and betulinic acid (BA), on inhibiting CRC progression...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28331177/baseline-dependent-effects-of-amphetamine-on-attention-are-associated-with-striatal-dopamine-metabolism
#9
Karly M Turner, James Peak, Thomas H J Burne
Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance. Our goal was to determine if attention in rats could be improved by low dose amphetamine in a baseline-dependent manner by examining the relationship between task performance, drug response and monoamine levels in corticostriatal tissue. Firstly, rats performed a signal detection task with varying signal durations before administration of saline, 0...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331163/in-vitro-evaluation-of-candidate-bacillus-spp-for-animal-feed
#10
Sirima Mingmongkolchai, Watanalai Panbangred
The aim of this study was to select aerobic spore-formers for animal feed based on their in vitro probiotic potential, including their enzyme-producing ability and safety assessment. Seven isolates out of 187 spore-forming bacteria were selected for their ability to produce cellulase (89.21-1668.32 U/ml), xylanase (1399.68-4351.10 U/ml), and phytase (2.72-28.70 U/ml). Among seven isolates, five had activities towards a broad range of p-nitrophenyl esters with acyl chain lengths from C2 to C12. The probiotic properties of all selected isolates varied with respect to their acid and bile salt tolerance under simulated gastrointestinal tract (GIT) conditions, and their adherence ability to human intestinal cell lines (Caco-2 and HT-29)...
March 22, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28330872/nadph-oxidase-1-supports-proliferation-of-colon-cancer-cells-by-modulating-reactive-oxygen-species-dependent-signal-transduction
#11
Agnes Juhasz, Susan Markel, Shikha Gaur, Han Liu, Jiamo Lu, Guojian Jiang, Xiwei Wu, Smitha Antony, Yongzhong Wu, Giovanni Melillo, Jennifer L Meitzler, Diana C Haines, Donna Butcher, Krishnendu Roy, James H Doroshow
Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation. NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates superoxide, is highly expressed in colon cancer. To investigate the role that NOX1 plays in colon cancer growth, we used shRNA to decrease NOX1 expression stably in HT-29 human colon cancer cells. The 80-90% decrease in NOX1 expression achieved by RNAi produced a significant decline in ROS production and a G1/S block that translated into a 2-3-fold increase in tumor cell doubling time without increased apoptosis...
March 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28330557/loss-of-anthocyanins-and-modification-of-the-anthocyanin-profiles-in-grape-berries-of-malbec-and-bonarda-grown-under-high-temperature-conditions
#12
Inés de Rosas, María Teresa Ponce, Emiliano Malovini, Leonor Deis, Bruno Cavagnaro, Pablo Cavagnaro
Malbec and Bonarda are the two most widely cultivated grape varieties in Argentina, and their derived red wines are recognized worldwide, being their intense color a major quality trait. The temperature during fruit ripening conditions berries color intensity. In the main viticulture region of Malbec and Bonarda a 2-3°C increase in temperature has been predicted for the upcoming years as consequence of the global climate change. In the present study, this predicted temperature raise was simulated under field-crop conditions, and its effect on anthocyanin pigmentation in berries of Malbec and Bonarda was monitored by HPLC analysis throughout the ripening process, in two growing seasons...
May 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28328497/synergistic-effects-of-nanodrug-ultrasound-hyperthermia-and-thermal-ablation-on-solid-tumors-an-animal-study
#13
Li-Chen Chiu, Sheng-Kai Wu, Win-Li Lin, Gin-Shin Chen
OBJECTIVE: Delivery barriers of nanodrug in large tumors due to heterogeneous blood supply, elevated interstitial pressure and long transport distances can degrade the efficacy of cancer treatment. In this study, we proposed a therapeutic strategy to improve the tumor growth inhibition by injecting pegylated liposomal doxorubicin (PLD), and then applying a short time of ultrasound hyperthermia (HT) on the entire solid tumor, and inflicting ultrasound thermal ablation (Ab) in the low-perfused tumor region...
March 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28327620/correlation-between-ultrasound-elastography-and-histologic-characteristics-of-papillary-thyroid-carcinoma
#14
Li Yi, Wu Qiong, Wang Yan, Fan Youben, Hu Bing
The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 126 papillary thyroid carcinomas (PTCs) from 103 patients who underwent ultrasonography and elastography before surgery. The histologic characteristics and clinicopathologic indexes were compared with the SR of ultrasound elastography (UE)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327109/a-cross-sectional-study-on-sarcopenia-using-different-methods-reference-values-for-healthy-saudi-young-men
#15
Shaea A Alkahtani
BACKGROUND: The aim of this study was to determine reference values for sarcopenia indices using different methods in healthy Saudi young men. METHODS: Participants included 232 Saudi men aged between 20 and 35 years. The study measured anthropometric indices, blood pressure, hand grip strength, and lean muscle mass using dual-energy X-ray absorptiometry (DXA), and bioelectrical impedance analysis (BIA) was performed using Inbody 770 and Tanita 980 devices. RESULTS: Using DXA, the mean value of appendicular lean mass divided by the height squared (ALM/ht(2)) was found to be 8...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28326855/impact-of-postoperative-pulmonary-hypertension-on-outcome-after-heart-transplantation
#16
Jakob Lundgren, Carl Söderlund, Göran Rådegran
OBJECTIVES: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). DESIGN: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund in the period 1988-2010 and who were evaluated with right-heart-catheterization at rest, prior to HT and repeatedly during the first postoperative year, were grouped based on their MPAP, DPG, and PVR...
March 22, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28326039/estrone-sulfate-transport-and-steroid-sulfatase-activity-in-colorectal-cancer-implications-for-hormone-replacement-therapy
#17
Lorna C Gilligan, Ali Gondal, Vivien Tang, Maryam T Hussain, Anastasia Arvaniti, Anne-Marie Hewitt, Paul A Foster
Hormone replacement therapy (HRT) affects the incidence and potential progression of colorectal cancer (CRC). As HRT primarily consists of estrone sulfate (E1S), understanding whether this conjugated estrogen is transported and metabolized in CRC will define its potential effect in this malignancy. Here, we show that a panel of CRC cell lines (Colo205, Caco2, HCT116, HT-29) have steroid sulfatase (STS) activity, and thus can hydrolyze E1S. STS activity is significantly higher in CRC cell lysate, suggesting the importance of E1S transport in intracellular STS substrate availability...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28326015/serotonin-regulates-the-firing-of-principal-cells-of-the-subiculum-by-inhibiting-a-t-type-ca-2-current
#18
Anders V Petersen, Camilla S Jensen, Valérie Crépel, Mathias Falkerslev, Jean-François Perrier
The subiculum is the main output of the hippocampal formation. A high proportion of its principal neurons fire action potentials in bursts triggered by the activation of low threshold calcium currents. This firing pattern promotes synaptic release and regulates spike-timing-dependent plasticity. The subiculum receives a high density of fibers originating from the raphe nuclei, suggesting that serotonin (5-HT) modulates subicular neurons. Here we investigated if and how 5-HT modulates the firing pattern of bursting neurons...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28325327/preparation-of-cellulose-nanocrystals-from-humulus-japonicus-stem-and-the-influence-of-high-temperature-pretreatment
#19
Yani Jiang, Jiping Zhou, Qi Zhang, Guoqi Zhao, Lin Heng, Dongdong Chen, Dongfang Liu
As one of the most abundant wild herbs in nature, the Humulus japonicus stem (HJS) is a new low-cost source of cellulosic material. In this work, cellulose nanocrystals (CNCs) were isolated from HJS using acid hydrolysis. The influence of high temperature pretreatment (HT pretreatment) on the properties and yields of these HT-HJS (HJS fibers after HT pretreatment at different temperatures) and HT-CNCs (CNCs prepared from the HT-HJS) was studied. The results showed that there was no variation of the chemical structure among the HT-HJS and HT-CNCs...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28325004/study-of-phase-estimation-methods-to-analyse-cardiorespiratory-synchronization-in-osa-patients
#20
Jordi Sola-Soler, Beatriz F Giraldo, Jose A Fiz, Raimon Jane
Obstructive Sleep Apnea (OSA) is a sleep disorder highly prevalent in the general population. Cardiorespiratory Phase Synchronization (CRPS) is a form of non-linear interaction between respiratory and cardiovascular systems that was found to be reduced in severe OSA patients. The Hilbert Transform (HT) method was the recommended choice for estimating the respiratory phase in CRPS studies. But we have noticed that HT provides a phase that is aligned to the transition between the exhalation and the inhalation parts of different breathing cycles, instead of being aligned to the breathing onsets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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