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https://www.readbyqxmd.com/read/29676681/frameless-robot-assisted-stereoelectroencephalography-in-children-technical-aspects-and-comparison-with-talairach-frame-technique
#1
Taylor J Abel, René Varela Osorio, Ricardo Amorim-Leite, Francois Mathieu, Philippe Kahane, Lorella Minotti, Dominique Hoffmann, Stephan Chabardes
OBJECTIVE Robot-assisted stereoelectroencephalography (SEEG) is gaining popularity as a technique for localization of the epileptogenic zone (EZ) in children with pharmacoresistant epilepsy. Here, the authors describe their frameless robot-assisted SEEG technique and report preliminary outcomes and relative complications in children as compared to results with the Talairach frame-based SEEG technique. METHODS The authors retrospectively analyzed the results of 19 robot-assisted SEEG electrode implantations in 17 consecutive children (age < 17 years) with pharmacoresistant epilepsy, and compared these results to 19 preceding SEEG electrode implantations in 18 children who underwent the traditional Talairach frame-based SEEG electrode implantation...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29676349/partial-corpus-callosal-agenesis-with-ventriculomegaly-and-sulcal-anomaly-in-a-10-year-old-child
#2
Austine Abebe Osawe, Saleh M Kabir, Anas Ismail
Agenesis of the corpus callosum is a heterogeneous, congenital neurodevelopmental condition that can be observed either in isolation or in combination with other brain abnormalities. Patients often present early with characteristic neurologic and physical manifestations. This case discusses a 10-year-old boy who presented to a tertiary health facility in Northern Nigeria with 6-month history of seizure disorder, cognitive impairment and urinary incontinence and had classical magnetic resonance imaging (MRI) findings consistent with partial corpus callosum agenesis in combination with other brain abnormalities...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29671836/children-s-experience-of-symptoms-narratives-through-words-and-images
#3
REVIEW
Barbara M Sourkes
Children who live with a complex chronic or life-threatening illness face extraordinary challenges. Whether they are receiving disease-oriented treatment (aimed at potential cure or prolongation of life) or palliative treatment-or both concurrently-our challenge is to enhance their comfort and minimize their distress. Symptom management is thus a critical component of pediatric palliative care. Symptoms may be either physical or psychological in nature (or a confluence of both) and their effective management has a direct impact on the child's quality of life...
April 19, 2018: Children
https://www.readbyqxmd.com/read/29622334/pediatric-major-head-injury-not-a-minor-problem
#4
REVIEW
Aaron N Leetch, Bryan Wilson
Traumatic brain injury is a highly prevalent and devastating cause of morbidity and mortality in children. A rapid, stepwise approach to the traumatized child should proceed, addressing life-threatening problems first. Management focuses on preventing secondary injury from physiologic extremes such as hypoxemia, hypotension, prolonged hyperventilation, temperature extremes, and rapid changes in cerebral blood flow. Initial Glasgow Coma Score, hyperglycemia, and imaging are often prognostic of outcome. Surgically amenable lesions should be evacuated promptly...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29602053/eeg-findings-and-outcomes-of-continuous-video-eeg-monitoring-started-prior-to-initiation-of-seizure-treatment-in-the-perinatal-stroke
#5
José R Castro Conde, Itziar Quintero Fuentes, Candelaria González Campo, Alejandro Jiménez Sosa, Beatriz Reyes Millán, Sergio Hernández Expósito
BACKGROUND: To analyze the findings in the background EEG activity of infants who suffered perinatal stroke. METHODS: Eleven neonates born 2009-2014 diagnosed of ischemic stroke by MRI (three of them with multistroke) underwent continuous video-EEG monitoring. Visual and spectral (power spectrum and coherence) analyses of the background EEG was performed in three moments: 1) Onset of EEG recording (prior to initiate seizure treatment), 2) Post-ictal epoch (1-2 h after the last seizure), and 3) one-two days after seizure control...
March 27, 2018: Early Human Development
https://www.readbyqxmd.com/read/29588956/high-frequency-oscillations-detected-in-ecog-recordings-correlate-with-cavernous-malformation-and-seizure-free-outcome-in-a-child-with-focal-epilepsy-a-case-report
#6
Su Liu, Michael M Quach, Daniel J Curry, Monika Ummat, Elaine Seto, Nuri F Ince
Epilepsy associated with cavernous malformation (CM) often requires surgical resection of seizure focus to achieve seizure-free outcome. High-frequency oscillations (HFOs) in intracranial electroencephalogram (EEG) are reported as potential biomarkers of epileptogenic regions, but to our knowledge there are no data on the existence of HFOs in CM-caused epilepsy. Here we report our experience of the identification of the seizure focus in a 3-year-old pediatric patient with intractable epilepsy associated with CM...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29584590/maternal-thyroid-function-in-early-pregnancy-and-child-neurodevelopmental-disorders-a-danish-nationwide-case-cohort-study
#7
Stine Linding Andersen, Stig Andersen, Peter Vestergaard, Jørn Olsen
BACKGROUND: Maternal thyroid dysfunction may adversely affect fetal brain development, but more evidence is needed to refine this hypothesis. The aim of this study was to evaluate potential fetal programming by abnormal maternal thyroid function on child neurodevelopmental disorders. METHODS: The design was a case-cohort study within the Danish National Birth Cohort (1997-2003). From the eligible cohort of 71,706 women, a random 12% sub-cohort (n = 7624) was selected, and all women (n = 2276) whose child was diagnosed with seizures, specific developmental disorder (SDD), autism spectrum disorder (ASD), and/or attention-deficit/hyperactivity disorder (ADHD) up to December 31, 2010, were identified...
March 27, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29579553/a-systematic-review-of-quality-of-life-in-parents-of-children-with-epilepsy
#8
REVIEW
Klajdi Puka, Tamara P Tavares, Kelly K Anderson, Mark A Ferro, Kathy N Speechley
OBJECTIVES: This systematic review aimed to 1) describe the quality of life (QOL) of parents of children with childhood-onset epilepsy (CWE), 2) identify factors associated with parental QOL, and 3) evaluate the association between parents' QOL and children's psychological well-being. METHODS: We conducted a comprehensive search of MEDLINE, EMBASE, and PsycINFO and conducted forward and backward citation tracking. A total of 15 articles met inclusion criteria. Parents' QOL was compared with population norms, healthy controls, and parents of children with other chronic conditions...
March 23, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29531931/thrombotic-thrombocytopenic-purpura-in-a-child-with-diabetic-ketoacidosis
#9
Neda Mostofizadeh, Serajaddin Arefnia, Mahin Hashemipour, Elham Hashemi Dehkordi
Thrombotic thrombocytopenic purpura (TTP) secondary to diabetic ketoacidosis has been rarely reported and is considered as a rare complication. If left untreated, this condition could be life threatening with considerable morbidity and mortality. Herein, we report a 6-year-old girl with reduced consciousness and respiratory distress with a history of polydipsia and polyuria in the 2 weeks before hospitalization. The patient was initially diagnosed as diabetic ketoacidosis based on clinical and laboratory findings and treated accordingly...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29530119/-clinical-features-of-enterococcus-faecium-meningitis-in-children
#10
Li-Yuan Wang, Xiao-Tang Cai, Zhi-Ling Wang, Shun-Li Liu, Yong-Mei Xie, Hui Zhou
OBJECTIVE: To summarize the clinical features of Enterococcus faecium meningitis in children. METHODS: The clinical data of nine children with Enterococcus faecium meningitis were analyzed. RESULTS: In all the nine children, Enterococcus faecium was isolated from blood, cerebrospinal fluid, or peripherally inserted central catheters; 6 (67%) patients were neonates, 2 (22%) patients were younger than 6 months, and 1 (11%) patient was three years and four months of age...
March 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29529558/chd2-epilepsy-polygraphic-documentation-of-self-induced-seizures-due-to-fixation-off-sensitivity
#11
Davide Caputo, Marina Trivisano, Federico Vigevano, Lucia Fusco
CHD2 gene has been described in association with different types of childhood myoclonic epilepsy and is emerging as a gene involved in photosensitivity alone or combined with epilepsy. Recent studies suggest that CHD2 could be responsible for a proper phenotype characterized by infantile-onset generalized epilepsy, intellectual disability, and photosensitivity and in particular with self-induced seizures. We report the case of a child with CHD2 mutation and mild developmental impairment that since the age of 3 years started with myoclonic seizures apparently well responding to antiepileptic drugs and that subsequently developed intractable self-induced seizures...
March 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29526578/cannabidiol-for-treatment-of-refractory-childhood-epilepsies-experience-from-a-single-tertiary-epilepsy-center-in-slovenia
#12
David Neubauer, Mirjana Perković Benedik, Damjan Osredkar
PURPOSE: Refractory epilepsies in children present a major burden for patients and their families. Cannabidiol (CBD) has been suggested as a potential treatment for refractory epilepsies. The aim of this study was to evaluate the effectiveness of add-on therapy with CBD for the treatment of refractory childhood epilepsies. METHOD: Patients with childhood-onset refractory epilepsy, treated at the tertiary epilepsy center of the University Children's Hospital Ljubljana, Slovenia, were included in the study...
March 8, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29523493/antecedents-of-screening-positive-for-attention-deficit-hyperactivity-disorder-in-ten-year-old-children-born-extremely-preterm
#13
Alan Leviton, Stephen R Hooper, Scott J Hunter, Megan N Scott, Elizabeth N Allred, Robert M Joseph, T Michael O'Shea, Karl Kuban
BACKGROUND: The incidence of attention deficit hyperactivity disorder is higher among children born very preterm than among children who are mature at birth. METHODS: We studied 583 ten-year-old children who were born before 28 weeks of gestation whose IQ was above 84 and had a parent-completed Child Symptom Inventory-4, which allowed classification of the child as having or not having symptoms of attention deficit hyperactivity disorder. For 422 children, we also had a teacher report, and for 583 children, we also had a parent report of whether or not a physician made an attention deficit hyperactivity disorder diagnosis...
December 21, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29520437/central-nervous-system-cns-neuroblastoma-a-case-based-update
#14
Federico Bianchi, Gianpiero Tamburrini, Marco Gessi, Paolo Frassanito, Luca Massimi, Massimo Caldarelli
BACKGROUND: Primary central nervous system (CNS) neuroblastoma is a rare intracranial tumor affecting children mainly in the first years of life. It is usually a supratentorial tumor with a wide spectrum of clinical presentation, seizures, and focal neurological deficits being the most common presenting signs. CASE DESCRIPTION: A 2-year-old child was admitted to our ward after a generalized seizure. Neurological examination was normal. Radiological studies showed a small DWI hyperintense lesion of the right rectus gyrus...
March 8, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29510713/prevalence-risk-factors-and-behavioural-and-emotional-comorbidity-of-acute-seizures-in-young-kenyan-children-a-population-based-study
#15
Symon M Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein, Charles R J C Newton
BACKGROUND: Acute symptomatic seizures and febrile seizures are common in children admitted to hospitals in Africa and may be markers of brain dysfunction. They may be associated with behavioural and emotional problems, but there are no published community-based studies in Africa. METHODS: We screened 7047 children aged 1-6 years (randomly sampled from 50,000 in the community) for seizures (using seven questions) and invited those who screened positive and a proportion of negatives for a clinical assessment...
March 7, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29482495/the-feasibility-of-using-actigraphy-to-characterize-sleep-in-rett-syndrome
#16
Alyssa M Merbler, Breanne J Byiers, John J Garcia, Timothy J Feyma, Frank J Symons
BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Sleep problems are reported by the majority of caregivers of individuals with RTT. METHODS: The present study aimed to replicate and extend previous work about the feasibility of measuring sleep with an actigraph device in a sample of girls with clinically diagnosed RTT (N = 13, mean age = 9 years, 5 months). Participants wore an actigraph device day and night for seven consecutive days...
February 27, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29479905/public-awareness-understanding-and-attitudes-towards-epilepsy-in-montenegro
#17
Sanja Vodopić, Slavica Vujisić
Stigma remains a distressing consequence of epilepsy worldwide. We assessed stigma markers among citizens of Montenegro. Randomly selected adults aged 18 to 65 were interviewed using a 10-item questionnaire, which had been used in similar settings. Descriptive statistics, χ2-test and Fisher exact test were used in order to identify factors associated with negative attitudes. After exclusions and refusals, the questionnaire was administered to 1000 people, 91% of whom had heard about epilepsy. Less than half knew someone with epilepsy and 31...
September 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29478218/mitochondrial-encephalopathy-first-portuguese-report-of-a-vars2-causative-variant
#18
Sandra Pereira, Mariana Adrião, Mafalda Sampaio, Margarida Ayres Basto, Esmeralda Rodrigues, Laura Vilarinho, Elisa Leão Teles, Isabel Alonso, Miguel Leão
INTRODUCTION: Combined oxidative phosphorylation deficiency 20 (COXPD20) is a mitochondrial respiratory chain complex (RC) disorder, caused by disease-causing variants in the VARS2 gene, which encodes a mitochondrial aminoacyl-tRNA synthetase. Here we describe a patient with fatal mitochondrial encephalopathy caused by a homozygous VARS2 gene missense variant. CASE REPORT: We report the case of a girl, the first child of non-consanguineous and healthy parents, born from an uneventful term pregnancy, who presented, in the neonatal period, major hypotonia and microcephaly...
February 25, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29465492/seizure-induced-increased-18f-dopa-uptake-in-a-child-with-diffuse-astrocytoma-and-transient-brain-mri-abnormalities-related-to-status-epilepticus
#19
Giovanni Morana, Gianluca Bottoni, Maria Margherita Mancardi, Antonio Verrico, Arnoldo Piccardo
We report the finding of increased F-DOPA uptake in the brain parenchyma surrounding a temporoparietal low-grade diffuse astrocytoma and corresponding to transient seizure-induced MRI abnormalities. There was concomitant markedly increased tumoral uptake. This F-DOPA PET phenomenon may represent increased amino acid transport induced by seizures. In the setting of brain tumor imaging, increased F-DOPA uptake of low-grade epileptogenic tumors and adjacent brain parenchyma should be carefully interpreted in light of clinical and electroencephalographic findings related to seizure activity...
February 21, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29461904/an-investigation-of-the-association-between-seizures-autism-symptomology-and-developmental-functioning-in-young-children
#20
Claire O Burns, Johnny L Matson
OBJECTIVE: The aim of the present study was to explore whether a history of seizures was associated with autism symptom severity and developmental functioning in young children. METHODS: Autism symptom severity and developmental functioning were compared between children with and without a history or seizures who either had atypical development or met criteria for autism spectrum disorder (ASD) based on review of records by a licensed clinical psychologist. RESULTS: Parents of children who met criteria for ASD reported lower levels of autism symptomology when the child had a history of seizures, while the opposite trend was found for children with atypical development...
February 20, 2018: Developmental Neurorehabilitation
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