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https://www.readbyqxmd.com/read/28625816/a-prospective-multicenter-study-evaluating-learning-curves-and-competence-in-endoscopic-ultrasound-and-endoscopic-retrograde-cholangiopancreatography-among-advanced-endoscopy-trainees-the-rapid-assessment-of-trainee-endoscopy-skills-rates-study
#1
Sachin Wani, Rajesh Keswani, Matt Hall, Samuel Han, Meer Akbar Ali, Brian Brauer, Linda Carlin, Amitabh Chak, Dan Collins, Gregory A Cote, David L Diehl, Christopher J DiMaio, Andrew Dries, Ihab El-Hajj, Swan Ellert, Kimberley Fairley, Ashley Faulx, Larissa Fujii-Lau, Srinivas Gaddam, Seng-Ian Gan, Jonathan P Gaspar, Chitiki Gautamy, Stuart Gordon, Cynthia Harris, Sarah Hyder, Ross Jones, Stephen Kim, Srinadh Komanduri, Ryan Law, Linda Lee, Rawad Mounzer, Daniel Mullady, V Raman Muthusamy, Mojtaba Olyaee, Patrick Pfau, Shreyas Saligram, Cyrus Piraka, Amit Rastogi, Laura Rosenkranz, Fadi Rzouq, Aditi Saxena, Raj J Shah, Violette C Simon, Aaron Small, Jayaprakash Sreenarasimhaiah, Andrew Walker, Andrew Y Wang, Rabindra R Watson, Robert H Wilson, Patrick Yachimski, Dennis Yang, Steven Edmundowicz, Dayna S Early
BACKGROUND AND AIMS: Based on the Next Accreditation System, trainee assessment should occur on a continuous basis with individualized feedback. We aimed to validate endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) learning curves among advanced endoscopy trainees (AETs) using a large national sample of training programs and to develop a centralized database that allows assessment of performance in relation to peers. METHODS: ASGE recognized training programs were invited to participate and AETs were graded on ERCP and EUS exams using a validated competency assessment tool that assesses technical and cognitive competence in a continuous fashion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28624577/identification-of-an-immune-specific-class-of-hepatocellular-carcinoma-based-on-molecular-features
#2
Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L Friedman, Myron Schwartz, Augusto Villanueva, Josep M Llovet
BACKGROUND AND AIMS: Agents that induce an immune response against tumors by altering T-cell regulation have increased survival times of patients with advanced-stage tumors, such as melanoma or lung cancer. We aimed to characterize molecular features of immune cells that infiltrate hepatocellular carcinomas (HCCs) to determine whether these types of agents might be effective against liver tumors. METHODS: We analyzed HCC samples from 956 patients. We separated gene expression profiles from tumor, stromal, and immune cells using a non-negative matrix factorization algorithm...
June 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28624141/serial-imaging-and-swan-sequence-of-developmental-venous-anomaly-thrombosis-with-hematoma-diagnosis-and-follow-up
#3
Boukobza Monique, Calvez Sandra, Henry-Feugeas Marie-Cécile, Laissy Jean-Pierre
Developmental venous anomalies (DVAs) are usually asymptomatic. We report a case of DVA thrombosis with recurrent tiny frontal hematoma in a 24-year-old man. The contribution of T2-GRE and SWAN sequences are discussed. Follow-up attested complete recanalization after anticoagulation.
June 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28624134/efficacy-of-response-guided-directly-observed-pegylated-interferon-and-self-administered-ribavirin-for-people-who-inject-drugs-with-hepatitis-c-virus-genotype-2-3-infection-the-activate-study
#4
Jason Grebely, Olav Dalgard, Evan B Cunningham, Behzad Hajarizadeh, Graham R Foster, Philip Bruggmann, Brian Conway, Markus Backmund, Geert Robaeys, Tracy Swan, Janaki Amin, Philippa S Marks, Sophie Quiene, Tanya L Applegate, Martin Weltman, David Shaw, Adrian Dunlop, Margaret Hellard, Julie Bruneau, Håvard Midgard, Stefan Bourgeois, Cornelia Staehelin, Gregory J Dore
BACKGROUND: There are few data on treatment for hepatitis C virus (HCV) infection among people with ongoing injecting drug use. This study evaluated the efficacy of response-guided therapy for chronic HCV genotypes 2/3 infection among people with ongoing injecting drug use or receiving opioid substitution therapy (OST). A secondary aim was to identify predictors of HCV treatment response. METHODS: ACTIVATE was a multicentre clinical trial recruited between 2012 and 2014...
June 14, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28614823/resistance-of-enteric-viruses-on-fomites
#5
Enagnon Kazali Alidjinou, Famara Sane, Swan Firquet, Pierre-Emmanuel Lobert, Didier Hober
Human enteric viruses are associated with several clinical features, especially gastroenteritis. Large amounts of these viruses can be released in the environment and spread to people. Enteric viruses are nonenveloped viruses and have displayed good survival in the environment. They can be significantly resistant in food and water but also on fomites, and this is thought to play a role in transmission, leading to sporadic cases or outbreaks. The survival of enteric viruses on fomites relies on many factors including the virus itself, fomite properties, and extrinsic environmental factors such as temperature or relative humidity...
June 15, 2017: Intervirology
https://www.readbyqxmd.com/read/28614804/in-vivo-kinetics-and-nonradioactive-imaging-of-rapidly-proliferating-cells-in-graft-versus-host-disease
#6
Nataliya P Buxbaum, Donald E Farthing, Natella Maglakelidze, Martin Lizak, Hellmut Merkle, Andrea C Carpenter, Brittany U Oliver, Veena Kapoor, Ehydel Castro, Gregory A Swan, Liliane M Dos Santos, Nicolas J Bouladoux, Catherine V Bare, Francis A Flomerfelt, Michael A Eckhaus, William G Telford, Yasmine Belkaid, Remy J Bosselut, Ronald E Gress
Hematopoietic stem cell transplantation (HSCT) offers a cure for cancers that are refractory to chemotherapy and radiation. Most HSCT recipients develop chronic graft-versus-host disease (cGVHD), a systemic alloimmune attack on host organs. Diagnosis is based on clinical signs and symptoms, as biopsies are risky. T cells are central to the biology of cGVHD. We found that a low Treg/CD4+ T effector memory (Tem) ratio in circulation, lymphoid, and target organs identified early and established mouse cGVHD. Using deuterated water labeling to measure multicompartment in vivo kinetics of these subsets, we show robust Tem and Treg proliferation in lymphoid and target organs, while Tregs undergo apoptosis in target organs...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28610605/adherence-to-response-guided-pegylated-interferon-and-ribavirin-for-people-who-inject-drugs-with-hepatitis-c-virus-genotype-2-3-infection-the-activate-study
#7
Evan B Cunningham, Behzad Hajarizadeh, Olav Dalgard, Janaki Amin, Margaret Hellard, Graham R Foster, Philip Bruggmann, Brian Conway, Markus Backmund, Geert Robaeys, Tracy Swan, Philippa S Marks, Sophie Quiene, Tanya L Applegate, Martin Weltman, David Shaw, Adrian Dunlop, Julie Bruneau, Håvard Midgard, Stefan Bourgeois, Maria Christine Thurnheer, Gregory J Dore, Jason Grebely
BACKGROUND: The aims of this analysis were to investigate treatment completion and adherence among people with ongoing injecting drug use or receiving opioid substitution therapy (OST) in a study of response-guided therapy for chronic HCV genotypes 2/3 infection. METHODS: ACTIVATE was a multicenter clinical trial recruited between 2012 and 2014. Participants with genotypes 2/3 were treated with directly observed peg-interferon alfa-2b (PEG-IFN) and self-administered ribavirin for 12 (undetectable HCV RNA at week 4) or 24 weeks (detectable HCV RNA at week 4)...
June 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28608275/robert-mathys-finger-prosthesis-of-the-proximal-interphalangeal-joint-a-retrospective-case-series-of-19-joints-in-17-patients
#8
J P Rijnja, P P G M Kouwenberg, S Ray, E T Walbeehm
INTRODUCTION: The Robert Mathys (RM) Finger is a hinged type of arthroplasty for the metacarpophalangeal and proximal interphalangeal (PIP) joint that compensates ligament instability. The aim of this study is to evaluate the outcomes and complications of RM Finger arthroplasty of the PIP joint. MATERIALS AND METHODS: A retrospective case series of 19 RM Finger arthroplasties of the PIP joint in 17 patients was performed with a median follow-up of 36 months. The active range of motion (AROM) was measured pre-operatively, at the 6-week follow-up, at the termination of hand therapy, and at the final follow-up...
June 12, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28608022/manipulation-of-local-environment-produces-different-diversity-outcomes-depending-on-location-within-a-river-network
#9
Brett M Tornwall, Christopher M Swan, Bryan L Brown
Ecologists have long been interested in mechanisms governing community composition and assembly. Spatial connectivity is one potential mechanism that can have a large influence on community processes. In accordance with network metrics such as closeness and betweenness, headwater streams are more isolated than mainstem streams. Theory and observational studies predict that community structure in isolated locations of dispersal networks should respond more strongly to manipulations of local conditions, whereas well-connected communities subject to high levels of dispersal should not respond strongly to local manipulations...
June 13, 2017: Oecologia
https://www.readbyqxmd.com/read/28607230/preventing-torture-for-people-deprived-of-freedom-the-atlantic-hope-and-black-swan-prison-model
#10
Ernest N Ogbozor, Mara L Schoeny, Andrew Baer
International law and minimum standards provide certain protection for detainees and prisoners of war (POW) against torture and ill-treatment. Places of detention and parties to conflicts are often monitored to ensure that they adhere to the required standards through, for example, visits to individual detainees and the assessment of facilities. However, monitoring between the point of arrest and eventual remand in prisons is largely inadequate. This paper explains an emerging model to enhance protection of prisoners through readiness training for prospective humanitarian personnel...
2017: Torture: Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture
https://www.readbyqxmd.com/read/28606654/management-of-marfan-syndrome-during-pregnancy-a-real-world-experience-from-a-joint-cardiac-obstetric-service
#11
Joanna C E-S Lim, Matthew Cauldwell, Roshni R Patel, Anselm Uebing, Ruth A Curry, Mark R Johnson, Michael A Gatzoulis, Lorna Swan
BACKGROUND: Pregnancy in Marfan Syndrome (MFS) is associated with increased maternal risk of cardiovascular events. Given the maternal and genetic risks, pre-conception counselling is essential to facilitate informed choices. Multidisciplinary antenatal care with regular imaging is mandatory and best delivered through a Joint Cardiac Obstetric Service (JCOS). The aim of this study was to compare the care delivered in a JCOS against recognised international standards (European Society of Cardiology (ESC))...
May 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28603697/dispersal-and-transmission-of-avian-paramyxovirus-serotype-4-among-wild-birds-and-domestic-poultry
#12
Renfu Yin, Pingze Zhang, Xinxin Liu, Yanyu Chen, Zhi Tao, Lili Ai, Junjiao Li, Yingying Yang, Mingxin Li, Cong Xue, Jing Qian, Xueli Wang, Jing Chen, Yong Li, Yanping Xiong, Jun Zhang, Tobias Stoeger, Yuhai Bi, Jianjun Chen, Zhuang Ding
Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it is an economically important poultry pathogen. Despite the existence of several published strains, very little is known about the distribution, host species, and transmission of APMV-4 strains. To better understand the relationships among these factors, we conducted an APMV-4 surveillance of wild birds and domestic poultry in six provinces of China suspected of being intercontinental flyways and sites of interspecies transmission...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28602499/susceptibility-weighted-angiography-and-diffusion-weighted-imaging-in-posterior-reversible-encephalopathy-syndrome-is-there-an-association-between-hemorrhage-cytotoxic-edema-blood-pressure-and-imaging-severity
#13
Shivaprakash Basavanthaiah Hiremath, Amol Anantrao Gautam, Shilpa Anil, Reji Thomas, Geena Benjamin
PURPOSE: To assess the significance of association and possible correlation between hemorrhage, cytotoxic edema, blood pressure and imaging severity in posterior reversible encephalopathy syndrome (PRES). MATERIALS AND METHODS: This retrospective study included the medical and imaging records of 35 consecutive patients with PRES. The clinical data analysis included the highest recorded blood pressure (BP) on the day of the ictus, MRI including spin-echo echo planar diffusion-weighted imaging (DWI), susceptibility weighted angiography (SWAN) and conventional sequences...
June 8, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28602322/trabecular-microbypass-stent-implantation-with-cataract-extraction-in%C3%A2-pseudoexfoliation-glaucoma
#14
Tanner J Ferguson, Russell Swan, Mitch Ibach, Justin Schweitzer, Ramu Sudhagoni, John P Berdahl
PURPOSE: To evaluate the safety and efficacy of a trabecular microbypass stent (iStent) combined with cataract surgery in patients with pseudoexfoliation glaucoma (PXG). SETTING: Vance Thompson Vision, Sioux Falls, South Dakota, USA. DESIGN: Retrospective case series. METHODS: Eyes with PXG had implantation of 1 stent. Data were collected preoperatively and postoperatively through 24 months. Data included intraocular pressure (IOP), number of glaucoma medications, the incidence of postoperative IOP pressure spikes of 15 mm Hg or higher at any timepoint, and the need for additional surgery...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28600088/invasive-hemodynamics-of-pulmonary-disease-and-the-right-ventricle
#15
REVIEW
David Silber, Justine Lachmann
Pulmonary hypertension (PH) falls into 5 groups, as defined by the World Health Organization. Swan-Ganz catheters determine precapillary versus postcapillary PH. The hemodynamic values of PH at rest and with vasodilatory challenge categorize the etiology of PH and guide treatment. RV maladaptations to increased pulmonary vascular resistance (PVR) and the chronicity of the right ventricle's (RV) response to increased PH and/or increased PVR can be understood with pressure-volume (PV) loops constructed with use of conductance catheters...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28597974/a-simple-cell-transport-device-keeps-culture-alive-and-functional-during-shipping
#16
Paula G Miller, Ying I Wang, Glen Swan, Michael L Shuler
Transporting living complex cellular constructs through the mail while retaining their full viability and functionality is challenging. During this process, cells often suffer from exposure to suboptimal life-sustaining conditions (e.g. temperature, pH), as well as damage due to shear stress. We have developed a transport device for shipping intact cell/tissue constructs from one facility to another that overcomes these obstacles. Our transport device maintained three different cell lines (Caco2, A549, and HepG2 C3A) individually on transwell membranes with high viability (above 97%) for 48 h under simulated shipping conditions without an incubator...
June 9, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28587840/control-of-biting-lice-mallophaga-a-review
#17
REVIEW
Giovanni Benelli, Alice Caselli, Graziano Di Di Giuseppe, Angelo Canale
The chewing lice (Mallophaga) are common parasites of different animals. Most of them infest terrestrial and marine birds, including pigeons, doves, swans, cormorants and penguins. Mallophaga have not been found on marine mammals but only on terrestrial ones, including livestock and pets. Their bites damage cattle, sheep, goats, horses and poultry, causing itch and scratch and arousing phthiriasis and dermatitis. Notably, Mallophaga can vector important parasites, such as the filarial heartworm Sarconema eurycerca...
June 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28569232/relationship-among-phosphorus-content-in-water-sediment-interface-in-middle-temperate-grassland
#18
E Jing Su Derong Lv Shihai Diao Zhaoyan Bu He Zheng Zhirong Ye Shengxing
In order to reveal the dynamic changes of phosphorus release from the sediments of the wetlands in mid-temperature steppe without external phosphorus input, the relationship among the phosphorus content in the overlying water, sediment and interstitial water was studied by using variables control method. In July of 2015, the undisturbed sediments and corresponding overlying water from the sediment-water interface of Hulunbeier steppe, China were selected (included Yimin River midstream (YM) wetland, Muqiao section (HM) wetland, Swan Lake (TE) wetland, Xiboqiao section (HX) wetland, Huihe and Yi Min River Interchange (HY) wetland and Hulun lake (HH) wetland) and cultured in wetland habitat simulator...
May 18, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28567210/potential-disease-transmission-from-wild-geese-and-swans-to-livestock-poultry-and-humans-a-review-of-the-scientific-literature-from-a-one-health-perspective
#19
Johan Elmberg, Charlotte Berg, Henrik Lerner, Jonas Waldenström, Rebecca Hessel
There are more herbivorous waterfowl (swans and geese) close to humans, livestock and poultry than ever before. This creates widespread conflict with agriculture and other human interests, but also debate about the role of swans and geese as potential vectors of disease of relevance for human and animal health. Using a One Health perspective, we provide the first comprehensive review of the scientific literature about the most relevant viral, bacterial, and unicellular pathogens occurring in wild geese and swans...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28561945/beta-blocker-administration-during-emergency-department-evaluation-for-acute-coronary-syndrome-is-associated-with-lower-posttraumatic-stress-symptoms-1-month-later
#20
Laura Meli, Bernard P Chang, Daichi Shimbo, Brendan W Swan, Donald Edmondson, Jennifer A Sumner
We examined whether beta blocker administration in the emergency department (ED) during evaluation for suspected acute coronary syndrome (ACS) was associated with posttraumatic stress disorder (PTSD) symptoms 1-month later. Participants (N = 350) were enrolled in the Reactions to Acute Care and Hospitalization (REACH) study, an ongoing observational cohort study of ED predictors of medical and psychological outcomes after evaluation for suspected ACS. Beta blockade during evaluation in the ED was extracted from medical records, and PTSD symptoms in response to the experience of suspected ACS were assessed 1-month later via telephone...
May 31, 2017: Journal of Traumatic Stress
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