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Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, Huidong Zhang
Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide (BPDE) is an endocrine disrupter and ultimate carcinogenic product of benzo(a)pyrene (BaP). Numerous studies have shown that BPDE causes trophoblast-related diseases, such as preeclampsia, growth restriction or miscarriages. However, the underlying mechanism, especially the mitochondria-related BPDE-induced trophoblast dysfunction remains unknown. In this study, we examined mitochondrial functions in BPDE-induced human trophoblast cell line Swan 71. BPDE decreased cell ability, attenuated cell invasion and HCG secretion, induced cell apoptosis, decreased mitochondrial membrane potential, increased reactive oxygen species (ROS) and MDA, and decreased SOD activity in a dose-dependent manner...
November 13, 2017: Environmental Pollution
Alyse K Hawley, Masaru K Nobu, Jody J Wright, W Evan Durno, Connor Morgan-Lang, Brent Sage, Patrick Schwientek, Brandon K Swan, Christian Rinke, Monica Torres-Beltrán, Keith Mewis, Wen-Tso Liu, Ramunas Stepanauskas, Tanja Woyke, Steven J Hallam
Microbial communities drive biogeochemical cycles through networks of metabolite exchange that are structured along energetic gradients. As energy yields become limiting, these networks favor co-metabolic interactions to maximize energy disequilibria. Here we apply single-cell genomics, metagenomics, and metatranscriptomics to study bacterial populations of the abundant "microbial dark matter" phylum Marinimicrobia along defined energy gradients. We show that evolutionary diversification of major Marinimicrobia clades appears to be closely related to energy yields, with increased co-metabolic interactions in more deeply branching clades...
November 15, 2017: Nature Communications
Salman Gohar, Ziad Taimeh, Jeff Morgan, O H Frazier, Francisco Arabia, Andrew Civitello, Ajith Nair
The temporary total artificial heart (TAH-t) has been valuable as a bridge to transplantation in patients with biventricular failure. However, the challenges of accurately assessing pulmonary vascular resistance after TAH-t implantation can preclude these patients from heart transplantation, especially those with pre-existing pulmonary hypertension. The CardioMEMS Heart Failure System (St. Jude's Medical, Little Canada, MN) comprises a wireless pressure sensor that is implanted percutaneously in the pulmonary artery and transmits real-time measurements of pulmonary artery pressures...
November 8, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Brandon D Swan, Lynne B Gasperson, Max O Krucoff, Warren M Grill, Dennis A Turner
BACKGROUND: Microstimulation in human sensory thalamus (ventrocaudal, VC) results in focal sensory percepts in the hand and arm which may provide an alternative target site (to somatosensory cortex) for the input of prosthetic sensory information. Sensory feedback to facilitate motor function may require simultaneous or timed responses across separate digits to recreate perceptions of slip as well as encoding of intensity variations in pressure or touch. OBJECTIVES: To determine the feasibility of evoking sensory percepts on separate digits with variable intensity through either a microwire array or deep brain stimulation (DBS) electrode, recreating "natural" and scalable percepts relating to the arm and hand...
October 27, 2017: Brain Stimulation
Ruth F Paterson, Sharon McNeill, Elaine Mitchell, Thomas Adams, Sarah C Swan, Dave Clarke, Peter I Miller, Eileen Bresnan, Keith Davidson
Fjordic coastlines provide an ideal protected environment for both finfish and shellfish aquaculture operations. This study reports the results of a cruise to the Scottish Clyde Sea, and associated fjordic sea lochs, that coincided with blooms of the diarrhetic shellfish toxin producing dinoflagellate Dinophysis acuta and the diatom genus Chaetoceros, that can generate finfish mortalities. Unusually, D. acuta reached one order of magnitude higher cell abundance in the water column (2840cellsL(-1)) than the more common Dinophysis acuminata (200cellsL(-1)) and was linked with elevated shellfish toxicity (maximum 601±237μg OA eq/kg shellfish flesh) which caused shellfish harvesting closures in the region...
November 2017: Harmful Algae
Tim A Kanters, Clazien A M Bouwmans, Naomi van der Linden, Siok Swan Tan, Leona Hakkaart-van Roijen
OBJECTIVES: Dutch health economic guidelines include a costing manual, which describes preferred research methodology for costing studies and reference prices to ensure high quality studies and comparability between study outcomes. This paper describes the most important revisions of the costing manual compared to the previous version. METHODS: An online survey was sent out to potential users of the costing manual to identify topics for improvement. The costing manual was aligned with contemporary health economic guidelines...
2017: PloS One
G A Mashour, M S Avidan
No abstract text is available yet for this article.
October 1, 2017: British Journal of Anaesthesia
S I Mortimer, S Hatcher, N M Fogarty, J H J van der Werf, D J Brown, A A Swan, R H Jacob, G H Geesink, D L Hopkins, J E Hocking Edwards, E N Ponnampalam, R D Warner, K L Pearce, D W Pethick
Genetic correlations between 29 wool production and quality traits and 25 meat quality and nutritional value traits were estimated for Merino sheep from an Information Nucleus (IN). Genetic correlations among the meat quality and nutritional value traits are also reported. The IN comprised 8 flocks linked genetically and managed across a range of sheep production environments in Australia. The wool traits included over 5,000 yearling and 3,700 adult records for fleece weight, fiber diameter, staple length, staple strength, fiber diameter variation, scoured wool color, and visual scores for breech and body wrinkle...
October 2017: Journal of Animal Science
Yoshitaka Hamada, Hiroaki Takai, Ryousuke Satoh, Naohito Hibino, Yukiko Ueda, Yoshitaka Minamikawa
We present seven cases of a relatively rare swan neck deformity resulting from chronic radial collateral ligament (RCL) injury of the proximal interphalangeal (PIP) joint in the little finger. All patients were middle-aged women (mean 51 years old, range 42-55), and the duration between the initial injury and surgery was 20 years (range 5-40). The chief complaint was painful snapping of the PIP joint. All patients had hyperextension and ulnar deviation of the PIP joint with mobile swan neck deformities that had not improved with conservative treatment...
January 1, 2017: Journal of Hand Surgery, European Volume
Amin Kiaghadi, Hanadi S Rifai, Daniel W Burleson
Hurricanes can cause widespread environmental pollution that has yet to be fully articulated. This study develops a predictive water quality model to forecast potential contamination resulting from buckled or ruptured storage tanks in coastal industrialized areas when subjected to storm surge. The developed EFDC-Storm Surge model (EFDC-SS) couples EPA's EFDC code with the SWAN-ADCIRC hurricane simulation model. EFDC-SS is demonstrated using the Houston Ship Channel in Texas as a testbed and hurricane Ike as a model hurricane...
November 2, 2017: Marine Pollution Bulletin
William Bassett, Jeremy Korsch, Kenneth G Swan
What role does arthroscopic surgery have in the treatment of patients with atraumatic meniscal tears and osteoarthritis? The authors reviewed the literature to find out.
November 2017: Journal of Family Practice
M De Lorenzi, M C Swan, C Easter, G P A Chanoit
OBJECTIVES: To describe the placement of self-inflating tissue expanders and clinical outcomes in 12 consecutive cases of reconstruction of distal cutaneous limb defects in dogs. MATERIALS AND METHODS: Cases of distal cutaneous limb defect were divided into three groups based on the location of the placement of the self-inflating tissue expanders: Group A (n=4): on, or proximal to, the elbow and stifle; Group B (n=4): distal to the elbow or stifle and proximal to the carpus or tarsus; and Group C (n=4): distal to the carpus or tarsus...
November 2, 2017: Journal of Small Animal Practice
Allison S Catalano, Kent Redford, Richard Margoluis, Andrew T Knight
Failure carries undeniable stigma and is difficult to confront for individuals, teams, and organizations. Disciplines such as commercial and military aviation, medicine, and business have long histories of grappling with it, beginning with the recognition that failure is inevitable in every human endeavor. While conservation may arguably be more complex, conservation professionals can draw upon the research and experience of these other disciplines to institutionalize activities and attitudes that foster learning from failures, whether they are minor setbacks or major disasters...
November 1, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
Leigha Senter, Robin L Bennett, Anne C Madeo, Sarah Noblin, Kelly E Ormond, Kami Wolfe Schneider, Kelli Swan, Alice Virani
The Code of Ethics (COE) of the National Society of Genetic Counselors (NSGC) was adopted in 1992 and was later revised and adopted in 2006. In 2016, the NSGC Code of Ethics Review Task Force (COERTF) was convened to review the COE. The COERTF reviewed ethical codes written by other professional organizations and suggested changes that would better reflect the current and evolving nature of the genetic counseling profession. The COERTF received input from the society's legal counsel, Board of Directors, and members-at-large...
October 27, 2017: Journal of Genetic Counseling
K Ruppert, J Cauley, Y Lian, J C Zgibor, C Derby, D H Solomon
This was a longitudinal study examining the effects of insulin use on bone mineral density loss. Insulin use was found to be associated with greater bone mineral density loss at the femoral neck among women with diabetes mellitus. INTRODUCTION: Women with diabetes mellitus (DM) have higher bone mineral density (BMD) and experience slower BMD loss but have an increased risk of fracture. The data regarding the effect of insulin treatment on BMD remains conflicted. We examined the impact of insulin initiation on BMD...
October 27, 2017: Osteoporosis International
Sean C Anderson, Trevor A Branch, Andrew B Cooper, Nicholas K Dulvy
No abstract text is available yet for this article.
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
Jason W Christopher, Bennett B Goldberg, Anna K Swan
Monolayer molybdenum disulfide (MoS2) has emerged as a model system for studying many-body physics because the low dimensionality reduces screening leading to tightly bound states stable at room temperature. Further, the many-body states possess a pseudo-spin degree of freedom that corresponds with the two direct-gap valleys of the band structure, which can be optically manipulated. Here we focus on one bound state, the negatively charged trion. Unlike excitons, trions can radiatively decay with non-zero momentum by kicking out an electron, resulting in an asymmetric trion photoluminescence (PL) peak with a long low-energy tail and peak position that differs from the zero momentum trion energy...
October 25, 2017: Scientific Reports
Fanny Sunden, Ishraq AlSadhan, Artem Lyubimov, Tzanko Doukov, Jeffrey Swan, Daniel Herschlag
Members of enzyme superfamilies specialize in different reactions but often exhibit catalytic promiscuity for one anothers reactions, consistent with catalytic promiscuity as an important driver in the evolution of new enzymes. Wanting to understand how catalytic promiscuity and other factors may influence evolution across a superfamily, we turned to the well-studied Alkaline Phosphatase (AP) superfamily, comparing three of its members-two evolutionarily distinct phosphatases and a phosphodiesterase. We mutated distinguishing active-site residues to generate enzymes that had a common Zn(2+) bimetallo core, but little sequence similarity and different auxiliary domains...
October 25, 2017: Journal of Biological Chemistry
Jérôme Raoul, Andrew A Swan, Jean-Michel Elsen
BACKGROUND: Building an efficient reference population for genomic selection is an issue when the recorded population is small and phenotypes are poorly informed, which is often the case in sheep breeding programs. Using stochastic simulation, we evaluated a genomic design based on a reference population with medium-density genotypes [around 45 K single nucleotide polymorphisms (SNPs)] of dams that were imputed from very low-density genotypes (≤ 1000 SNPs). METHODS: A population under selection for a maternal trait was simulated using real genotypes...
October 24, 2017: Genetics, Selection, Evolution: GSE
Sasan Fereidouni, M Jenckel, A Seidalina, K Karamendin, M Beer, E Starick, S Asanova, E Kasymbekov, M Sayatov, A Kydyrmanov
Five avian paramyxoviruses of serotype 8 (APMV-8) were isolated during a study monitoring wild birds in Kazakhstan in 2013 and each was further characterized. The viruses were isolated from three White-fronted geese (Anser albifrons), one Whooper swan (Cygnus cygnus), and one Little stint (Calidris minuta). Before our study, only two complete APMV-8 sequences had been reported worldwide since their discovery in the USA and Japan in the 1970s. We report the complete genome sequences of the newly detected viruses and analyze the genetic evolution of the APMV-8 viruses over four decades...
October 22, 2017: Archives of Virology
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