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J T Nelson, A A Swan, B Swiger, M Packer, M J Pugh
Hearing loss is the second most common disability awarded by the U.S. Department of Veterans Affairs (VA) to former members of the U.S. uniformed services. Hearing readiness and conservation practices differ among the four largest uniformed military services (Air Force, Army, Marine Corps, and Navy). Utilizing a data set consisting of all hearing loss claims submitted to the VA from fiscal years 2003-2013, we examined characteristics of veterans submitting claims within one year of separation from military service...
October 18, 2016: Hearing Research
Qian Qi, Mary M Cavanagh, Sabine Le Saux, Lisa E Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E Swan, Mark M Davis, Cornelia L Dekker, Lu Tian, Cornelia M Weyand, Jörg J Goronzy
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age...
October 2016: PLoS Pathogens
Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
INTRODUCTION: Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encoding RAGE). We aimed to (i) characterise RAGE expression in the lung, (ii) identify AGER transcripts, (iii) ascertain if SNP rs2070600 (Gly82Ser C/T) is associated with lung function and serum sRAGE levels and (iv) identify whether the Gly82Ser variant is functionally important in altering sRAGE levels in an airway epithelial cell model...
2016: PloS One
Ellen B Gold, Sybil L Crawford, Janie F Shelton, Ping G Tepper, Carolyn J Crandall, Gail A Greendale, Karen A Matthews, Rebecca C Thurston, Nancy E Avis
OBJECTIVE: Greater body mass index (BMI) and body fat are associated with vasomotor symptoms (VMS). Thus, weight loss may prevent VMS. We analyzed whether concurrent BMI or waist circumference and/or changes in weight or waist circumference predicted incident VMS and whether these relations differed by menopause stage or race/ethnicity. METHODS: Data from 10 follow-up visits for 1,546 participants in the Study of Women's Health Across the Nation who reported no VMS at baseline were modeled for time to first symptomatic visit in relation to concurrent BMI and waist circumference and change in weight and waist circumference during early and late menopause using discrete survival analyses, adjusting for covariates...
October 3, 2016: Menopause: the Journal of the North American Menopause Society
Holly Sitters, Alan York, Matthew Swan, Fiona Christie, Julian Di Stefano
Disturbance regimes are changing worldwide, and the consequences for ecosystem function and resilience are largely unknown. Functional diversity (FD) provides a surrogate measure of ecosystem function by capturing the range, abundance and distribution of trait values in a community. Enhanced understanding of the responses of FD to measures of vegetation structure at landscape scales is needed to guide conservation management. To address this knowledge gap, we used a whole-of-landscape sampling approach to examine relationships between bird FD, vegetation diversity and time since fire...
2016: PloS One
Ying Swan Ho, Lian Yee Yip, Nurhidayah Basri, Vivian Su Hui Chong, Chin Chye Teo, Eddy Tan, Kah Ling Lim, Gek San Tan, Xulei Yang, Si Yong Yeo, Mariko Si Yue Koh, Anantham Devanand, Angela Takano, Eng Huat Tan, Daniel Shao Weng Tan, Tony Kiat Hon Lim
Cytology and histology forms the cornerstone for the diagnosis of non-small cell lung cancer (NSCLC) but obtaining sufficient tumour cells or tissue biopsies for these tests remains a challenge. We investigate the lipidome of lung pleural effusion (PE) for unique metabolic signatures to discriminate benign versus malignant PE and EGFR versus non-EGFR malignant subgroups to identify novel diagnostic markers that is independent of tumour cell availability. Using liquid chromatography mass spectrometry, we profiled the lipidomes of the PE of 30 benign and 41 malignant cases with or without EGFR mutation...
October 14, 2016: Scientific Reports
Tatsufumi Usui, Kosuke Soda, Yukiko Tomioka, Hiroshi Ito, Toshiyo Yabuta, Hiroki Takakuwa, Koichi Otsuki, Toshihiro Ito, Tsuyoshi Yamaguchi
Since 2014, clade H5 subtype highly pathogenic avian influenza viruses (HPAIVs) have been distributed worldwide. These viruses, which were reported to be highly virulent in chickens by intravenous inoculation, have a consensus HPAI motif PLRERRRKR at the HA cleavage site. However, two-clade H5N8 viruses which we isolated from wild migratory birds in late 2014 in Japan possessed atypical HA cleavage sequences. A swan isolate, Tottori/C6, had a novel polybasic cleavage sequence, PLGERRRKR, and another isolate from a dead mandarin duck, Gifu/01, had a heterogeneous mixture of consensus PLRERRRKR and variant PLRERRRRKR sequences...
October 13, 2016: Virus Genes
Yong Zhang, Herbert H T Prins, Martijn Versluijs, Rick Wessels, Lei Cao, Willem Frederik de Boer
When differently sized species feed on the same resources, interference competition may occur, which may negatively affect their food intake rate. It is expected that competition between species also alters behaviour and feeding patch selection. To assess these changes in behaviour and patch selection, we applied an experimental approach using captive birds of three differently sized Anatidae species: wigeon (Anas penelope) (~600 g), swan goose (Anser cygnoides) (~2700 g) and bean goose (Anser fabalis) (~3200 g)...
2016: PloS One
B J Heijnen, R Speyer, B Kertscher, R Cordier, K W J Koetsenruijter, K Swan, H Bogaardt
Introduction. Patients with head and neck cancer suffer from various impairments due to the primary illness, as well as secondary consequences of the oncological treatment. This systematic review describes the effects of radiotherapy and/or chemotherapy on the functions of the upper aerodigestive tract in patients with head and neck cancer. Methods. A systematic literature search was performed by two independent reviewers using the electronic databases PubMed and Embase. All dates up to May 2016 were included...
2016: BioMed Research International
M Tofazzal Islam, Daniel Croll, Pierre Gladieux, Darren M Soanes, Antoine Persoons, Pallab Bhattacharjee, Md Shaid Hossain, Dipali Rani Gupta, Md Mahbubur Rahman, M Golam Mahboob, Nicola Cook, Moin U Salam, Musrat Zahan Surovy, Vanessa Bueno Sancho, João Leodato Nunes Maciel, Antonio NhaniJúnior, Vanina Lilián Castroagudín, Juliana T de Assis Reges, Paulo Cezar Ceresini, Sebastien Ravel, Ronny Kellner, Elisabeth Fournier, Didier Tharreau, Marc-Henri Lebrun, Bruce A McDonald, Timothy Stitt, Daniel Swan, Nicholas J Talbot, Diane G O Saunders, Joe Win, Sophien Kamoun
BACKGROUND: In February 2016, a new fungal disease was spotted in wheat fields across eight districts in Bangladesh. The epidemic spread to an estimated 15,000 hectares, about 16 % of the cultivated wheat area in Bangladesh, with yield losses reaching up to 100 %. Within weeks of the onset of the epidemic, we performed transcriptome sequencing of symptomatic leaf samples collected directly from Bangladeshi fields. RESULTS: Reinoculation of seedlings with strains isolated from infected wheat grains showed wheat blast symptoms on leaves of wheat but not rice...
October 3, 2016: BMC Biology
Bruce A Bowser, Norbert G Campeau, Carrie M Carr, Felix E Diehn, Jennifer S McDonald, Gary M Miller, Timothy J Kaufmann
INTRODUCTION: Ferumoxytol (Feraheme) is a parenteral therapy approved for treatment of iron deficiency anemia. The product insert for ferumoxytol states that it may affect the diagnostic ability of MRI for up to 3 months. However, the expected effects may not be commonly recognized among clinical neuroradiologists. Our purpose is to describe the artifacts we have seen at our institution during routine clinical practice. METHODS: We reviewed the patients at our institution that had brain MRI performed within 90 days of receiving intravenous ferumoxytol...
October 4, 2016: Neuroradiology
Xiaomei Zhou, Catherine J Mondloch
We investigated recognition of familiar and unfamiliar own- and other-race faces across natural variability in appearance. Participants sorted 20 photographs of each of two identities into piles such that each pile contained all photographs of a single identity. The other-race effect was limited to unfamiliar faces. When faces were unfamiliar, participants perceived more identities when sorting other-race races; when faces were familiar, participants made two piles for both own- and other-race faces. Our work calls for rethinking the concept of the other-race effect...
September 28, 2016: Perception
Vicki Hart, Susan R Sturgeon, Nicholas Reich, Lynnette Leidy Sievert, Sybil L Crawford, Ellen B Gold, Nancy E Avis, Katherine W Reeves
PURPOSE: Two case-control studies reported a 50 % decreased breast cancer risk among women who experienced menopausal vasomotor symptoms (VMS), but one cohort study found no association. VMS may be triggered by declining estrogen levels during menopause, whereas elevated estrogen levels have been associated with increased breast cancer risk. VMS may thus be indicative of lower susceptibility to breast cancer. METHODS: We evaluated this relationship in the longitudinal Study of Women's Health Across the Nation (SWAN), using discrete survival analysis of approximately annual data on VMS and self-reported breast cancer occurrences for up to 13 years of follow-up in 3,098 women who were pre- or early perimenopausal at enrollment...
September 28, 2016: Cancer Causes & Control: CCC
C Vu, E Hernly, E Carey, K Swan
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Barbara Sternfeld, Alicia Colvin, Andrea Stewart, Sheila Dugan, Lisa Nackers, Samar R El Khoudary, Mei-Hua Huang, Carrie Karvonen-Gutierrez
PURPOSE: To examine the prospective association between healthy lifestyle behaviors and objectively measured physical function in midlife women. METHODS: Participants included 1,769 racially/ethnically diverse women, ages 56-68, from the SWAN (Study of Women's Health Across the Nation) cohort. Physical function was assessed at the 13th follow-up (FU13) visit with the Short Physical Performance Battery (4 meter walk, repeated chair stands, and balance test) and grip strength...
September 23, 2016: Medicine and Science in Sports and Exercise
Sheela Sathyanarayana, Emily Barrett, Ruby Nguyen, Bruce Redmon, Wren Haaland, Shanna H Swan
Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010-2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex...
2016: International Journal of Environmental Research and Public Health
Amy E Anderson, David J Swan, Oi Yean Wong, Matthew Buck, Oliver Eltherington, Rachel A Harry, Angela M Patterson, Arthur G Pratt, Gary Reynolds, John-Paul Doran, John A Kirby, John D Isaacs, Catharien M U Hilkens
Tolerogenic dendritic cells (tolDC) are a new immunotherapeutic tool for the treatment of rheumatoid arthritis (RA) and other autoimmune disorders. We have established a method to generate stable tolDC by pharmacological modulation of human monocyte-derived DC. These tolDC exert potent pro-tolerogenic actions on CD4(+) T-cells. Lack of IL-12p70 production is a key immunoregulatory attribute of tolDC but does not fully explain their action. Here we show that tolDC express TGF-β1 at both mRNA and protein level, and that expression of this immunoregulatory cytokine is significantly higher in tolDC than in mature monocyte-derived DC...
September 26, 2016: Clinical and Experimental Immunology
Diogo H Kita, Katlyn B Meyer, Amanda C Venturelli, Rafaella Adams, Daria L B Machado, Rosana N Morais, Shanna H Swan, Chris Gennings, Anderson J Martino-Andrade
We examined the anogenital distance (AGD) plasticity in rats through the manipulation of the androgen environment in utero and during puberty. Dams were treated from gestation days 13-20 with vehicle, flutamide (20mg/kg/day), di-(2-ethylhexyl) phthalate (DEHP, 750mg/kg/day), or testosterone (1.0mg/kg/day). After weaning, male pups were randomly assigned to one of four postnatal groups, which received the same treatments given prenatally. Sixteen treatment groups were established based on the combination of pre- and postnatal exposures...
August 10, 2016: Toxicology
Karen Ling Kwong, David Lam, Sarah Tsui, Mary Ngan, Brian Tsang, Tai Sum Lai, Siu Man Lam
PURPOSE: This study evaluated self-esteem in adolescents with epilepsy and its association with psychosocial and disease-related variables. METHODS: This was a cross-sectional study with patients enrolled between January and June 2010. Culture-Free Self-Esteem Inventory for Children (CFSEI-2) was administered to 140 children with epilepsy and 50 children with asthma, aged 10-18years attending mainstream schools. RESULTS: Adolescents with epilepsy had a significantly lower overall self-esteem score when compared with those with asthma, 17±5...
October 2016: Epilepsy & Behavior: E&B
Sheila A Dugan, Kelly Karavolos, Elizabeth B Lynch, Chiquia S Hollings, Francis Fullam, Brittney S Lange-Maia, Lynda H Powell
BACKGROUND: Physical inactivity in midlife women is associated with increased intra-abdominal adipose tissue development. We describe an innovative multimethod study 1) to better understand barriers to physical activity (PA) and 2) engage midlife women to product test physical activities and identify local community-based providers and sustainable and fun PA experiences. METHODS: Formative research on PA barriers from the Chicago site SWAN ancillary study of midlife women was utilized to develop a pilot testing measure...
August 24, 2016: Journal of Physical Activity & Health
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