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https://www.readbyqxmd.com/read/29776964/arrhythmias-in-adult-patients-with-congenital-heart-disease-and-pulmonary-arterial-hypertension
#1
Maria Drakopoulou, Heba Nashat, Aleksander Kempny, Rafael Alonso-Gonzalez, Lorna Swan, Stephen J Wort, Laura C Price, Colm McCabe, Tom Wong, Michael A Gatzoulis, Sabine Ernst, Konstantinos Dimopoulos
OBJECTIVES: Approximately 5%-10% of adults with congenital heart disease (CHD) develop pulmonary arterial hypertension (PAH), which affects life expectancy and quality of life. Arrhythmias are common among these patients, but their incidence and impact on outcome remains uncertain. METHODS: All adult patients with PAH associated with CHD (PAH-CHD) seen in a tertiary centre between 2007 and 2015 were followed for new-onset atrial or ventricular arrhythmia. Clinical variables associated with arrhythmia and their relation to mortality were assessed using Cox analysis...
May 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29775798/to-detect-or-not-to-detect-a-replication-and-extension-of-the-three-stage-model
#2
Alexander B Swan, Dustin P Calvillo, Russell Revlin
When faced with a decision, people generally show a bias toward heuristic processing, even if it leads to the incorrect decision, such as in the base-rate neglect task. The crucial question is whether people know that they are biased. Recently, the three-stage model (Pennycook, Fugelsang, & Koehler, 2015) suggested that detecting this bias (conflict detection) is imperfect and a consistent source of bias because some people do not recognize that they are making biased decisions. In Experiment 1, participants completed a base-rate neglect task as replication of Pennycook et al...
May 15, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29774963/glucocorticoid-signaling-regulates-cell-invasion-and-migration-in-the-human-first-trimester-trophoblast-cell-line-sw-71
#3
Edwina P Kisanga, Zhonghua Tang, Seth Guller, Shannon Whirledge
PROBLEM: The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic-pituitary-adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the inflammatory and stress response. Although the glucocorticoid receptor (GR) is expressed in all human villous trophoblast tissue, the effect of glucocorticoids on placentation is not well understood. METHOD OF STUDY: Using microarray analysis, we identified the glucocorticoid-regulated transcriptional profile in the immortalized first-trimester extravillous trophoblast cell line Swan...
May 18, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29768283/cerebral-oxygenation-as-a-monitoring-parameter-for-mortality-during-venoarterial-extracorporeal-membrane-oxygenation
#4
Hyoung Soo Kim, Sang Ook Ha, Kyung-Ho Yu, Mi Sun Oh, Sunghoon Park, Sun Hee Lee, Sang Jin Han, Hyun-Sook Kim, In Bok Chang, Jun Hyong Ahn
There are no recommended guidelines for monitoring parameters during venoarterial extracorporeal membrane oxygenation (VA-ECMO). We evaluated whether regional cerebral oxygen saturation (rScO2) could be a monitoring parameter for mortality during VA-ECMO. We retrospectively searched our database for adult patients who underwent VA-ECMO between April 2015 and October 2016 and identified 21 patients with rScO2 data. Their baseline and clinical characteristics during the first 7 days (vital signs, arterial blood gas results, ECMO variables, rScO2, Swan-Ganz catheter parameters, transthoracic echocardiography parameters, and outcomes) were collected and evaluated for associations with 28 day mortality...
May 15, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29763651/ejection-fraction-the-swan-song-of-a-timeless-index-or-the-battle-against-strain-will-still-go-on
#5
EDITORIAL
Kalliopi Keramida, Nikolaos Kouris
No abstract text is available yet for this article.
May 12, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29763492/perianal-extramammary-paget-disease-treated-with-topical-imiquimod-and-oral-cimetidine
#6
Jayla Gray, Arielle Gray, James Swan, Joshua Eberhardt, Kumaran Mudaliar, Rebecca Tung
Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma. The current mainstay of treatment is wide local excision. We present the case of a 56-year-old woman with perianal EMPD that recurred 4 years after initial treatment with wide local excision with Mohs micrographic surgery tissue processing of marginal tissue. Upon recurrence with anal canal involvement, the patient was treated with a 16-week combination course of topical imiquimod and oral cimetidine. There is growing evidence to support both the use of topical imiquimod for the treatment of EMPD as well as the antioncogenic effects of oral cimetidine...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29760739/antiarrhythmic-effects-of-carvedilol-and-flecainide-in-cardiomyocytes-derived-from-catecholaminergic-polymorphic-ventricular-tachycardia-patients
#7
R P Pölönen, K Penttinen, H Swan, K Aalto-Setälä
Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carrying different mutations in RYR2. iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion and L4115 or V4653F mutation in RYR2 and of a healthy individual. Ca2+ kinetics and drug effects were studied with Fluo-4 AM indicator...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29757002/a-gradual-effects-model-for-single-case-designs
#8
Daniel M Swan, James E Pustejovsky
Single-case designs are a class of repeated measures experiments used to evaluate the effects of interventions for small or specialized populations, such as individuals with low-incidence disabilities. There has been growing interest in systematic reviews and syntheses of evidence from single-case designs, but there remains a need to further develop appropriate statistical models and effect sizes for data from the designs. We propose a novel model for single-case data that exhibit nonlinear time trends created by an intervention that produces gradual effects, which build up and dissipate over time...
May 14, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29752389/pregnancy-in-women-with-a-fontan-circulation-a-systematic-review-of-the-literature
#9
Alvaro Garcia Ropero, Shankar Baskar, Jolien W Roos Hesselink, Andrea Girnius, Dominica Zentner, Lorna Swan, Magalie Ladouceur, Nicole Brown, Gruschen R Veldtman
BACKGROUND: The Fontan operation has provided life-saving palliation and adult survival for individuals born with single ventricle physiology. Many now seek advice about safe pregnancy. Little data are, however, available, consisting mainly of anecdotal experience and small series. This article seeks to review the published literature and identify lessons learnt from this collective experience. METHODS AND RESULTS: We conducted a systematic review to evaluate maternal and fetal outcomes of pregnancy in women with a Fontan circulation...
May 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29746404/diagnostic-and-therapeutic-challenges
#10
Kevin I Rosenberg, Robert Swan, Robert Hampton
No abstract text is available yet for this article.
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29745185/-growth-adaptability-of-zostera-marina-at-different-habitats-of-the-swan-lake-in-rongcheng-china
#11
Mei Yu Guo, Wen Tao Li, Xiao Long Yang, Xiu Mei Zhang, Jian Ying Liu, Chang Jun Li
Eelgrass (Zostera marina), a seagrass species widely distributed in the coastal regions of northern hemisphere, has suffered with a great decline due to a variety of anthropogenic and environmental stresses. In order to examine the adaptability of eelgrass to different environmental stresses, studies on the morphology and reproductive capacity of eelgrass had been carried out monthly from November 2014 to October 2015 at four different habitats of the Swan Lake, including patch area inintertidal area and subtidal area, eelgrass meadow edge, and eelgrass meadow area...
May 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29740400/the-role-of-kcnq1-mutations-and-maternal-beta-blocker-use-during-pregnancy-in-the-growth-of-children-with-long-qt-syndrome
#12
Heta Huttunen, Matti Hero, Mitja Lääperi, Johanna Känsäkoski, Heikki Swan, Joel A Hirsch, Päivi J Miettinen, Taneli Raivio
Objective: Two missense mutations in KCNQ1 , an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patients with long QT syndrome 1 (LQT1) due to loss-of-function mutations in KCNQ1 . Design: Medical records of 104 patients with LQT1 in a single tertiary care center between 1995 and 2015 were retrospectively reviewed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29734620/effects-of-pond-management-on-biodiversity-patterns-and-community-structure-of-zooplankton-in-urban-environments
#13
Jamie G Suski, Christopher M Swan, Christopher J Salice, Charles F Wahl
As urban areas continue expanding, major cities become connected forming megacities. Urban encroachment into natural areas transforms the landscape into a built environment with heterogeneously distributed patches of novel habitat. Community structure within novel habitats is influenced by anthropogenic factors including fragmentation and species interactions. Alterations in complex biodiversity patterns may be used to assess how urban stressors impact community assemblages which, ultimately, may inform sustainable management decisions...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29730336/reply-to-shukla-et-al-commentary-on-prenatal-exposure-to-acetaminophen-and-children-s-language-development-at-30-months
#14
EDITORIAL
Carl-Gustaf Bornehag, Avi Reichenberg, Maria Unenge Hallerback, Sverre Wikstrom, Holger M Koch, Shanna H Swan
No abstract text is available yet for this article.
May 3, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29730148/mri-derived-regional-biventricular-function-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-before-and-after-pulmonary-endarterectomy
#15
Sabine K Maschke, Christian O Schoenfeld, Till F Kaireit, Serghei Cebotari, Karen Olsson, Marius Hoeper, Frank Wacker, Jens Vogel-Claussen
RATIONALE AND OBJECTIVES: The aim of this study was to assess regional myocardial function in patients with chronic thromboembolic hypertension (CTEPH) before and after successful pulmonary endarterectomy (PEA) using magnetic resonance imaging. METHODS: Twenty-two patients with CTEPH underwent cardiac magnetic resonance imaging before and 12 (11, 17) days after PEA. Mean pulmonary artery pressure was evaluated preoperatively by right heart catheterization and during post-PEA intensive care unit-stay using a Swan-Ganz catheter...
May 2, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29728621/migratory-whooper-swans-cygnus-cygnus-transmit-h5n1-virus-between-china-and-mongolia-combination-evidence-from-satellite-tracking-and-phylogenetics-analysis
#16
Shuhong Li, Weiyue Meng, Dongping Liu, Qiqi Yang, Lixia Chen, Qiang Dai, Tian Ma, Ruyi Gao, Wendong Ru, Yunfeng Li, Pengbo Yu, Jun Lu, Guogang Zhang, Huaiyu Tian, Hongliang Chai, Yanbing Li
In late 2014, a highly pathogenic avian influenza (hereafter HPAI) H5N1 outbreak infected whooper swans Cygnus cygnus wintering at the Sanmenxia Reservoir area, China, and raised concerns about migratory linkages between wintering and breeding grounds of whooper swans. In this study, 61 swans were satellite tracked from 2013 to 2016 to determine the spatial association of their migration routes and H5N1 outbreaks, and 3596 fecal samples were collected along the migration routes for virology testing. Swans departed the wintering grounds and migrated along the Yellow River, and flew over the Yin Mountains in China...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29725695/alternatives-to-the-swan-ganz-catheter
#17
REVIEW
Daniel De Backer, Jan Bakker, Maurizio Cecconi, Ludhmila Hajjar, Da Wei Liu, Suzanna Lobo, Xavier Monnet, Andrea Morelli, Sheila Neinan Myatra, Azriel Perel, Michael R Pinsky, Bernd Saugel, Jean-Louis Teboul, Antoine Vieillard-Baron, Jean-Louis Vincent
While the pulmonary artery catheter (PAC) is still interesting in specific situations, there are many alternatives. A group of experts from different backgrounds discusses their respective interests and limitations of the various techniques and related measured variables. The goal of this review is to highlight the conditions in which the alternative devices will suffice and when they will not or when these alternative techniques can provide information not available with PAC. The panel concluded that it is useful to combine different techniques instead of relying on a single one and to adapt the "package" of interventions to the condition of the patient...
May 3, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29720545/multifocal-demyelinating-motor-neuropathy-and-hamartoma-syndrome-associated-with-a-de-novo-pten-mutation
#18
Boglarka Bansagi, Vietxuan Phan, Mark R Baker, Julia O'Sullivan, Matthew J Jennings, Roger G Whittaker, Juliane S Müller, Jennifer Duff, Helen Griffin, James A L Miller, Grainne S Gorman, Hanns Lochmüller, Patrick F Chinnery, Andreas Roos, Laura E Swan, Rita Horvath
OBJECTIVE: To describe a patient with a multifocal demyelinating motor neuropathy with onset in childhood and a mutation in phosphatase and tensin homolog ( PTEN ), a tumor suppressor gene associated with inherited tumor susceptibility conditions, macrocephaly, autism, ataxia, tremor, and epilepsy. Functional implications of this protein have been investigated in Parkinson and Alzheimer diseases. METHODS: We performed whole-exome sequencing in the patient's genomic DNA validated by Sanger sequencing...
May 2, 2018: Neurology
https://www.readbyqxmd.com/read/29716572/the-association-among-emotions-and-food-choices-in-first-year-college-students-using-mobile-ecological-momentary-assessments
#19
Jessica Ashurst, Irene van Woerden, Genevieve Dunton, Michael Todd, Punam Ohri-Vachaspati, Pamela Swan, Meg Bruening
BACKGROUND: Studies have examined the associations between emotions and overeating but have only rarely considered associations between emotions and specific food choices. The purpose of this secondary data analysis was to use mobile ecological momentary assessments (mEMAs) to examine associations between emotions and food choices among first-year college students living in residence halls. METHODS: Using an intensive repeated-measures design, mEMAs were used to assess concurrent emotions and food choices in a racially/ethnically diverse sample of first-year college students (n = 663)...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29704912/religiosity-and-faith-in-relation-to-time-to-metabolic-syndrome-for-hispanic-women-in-a-multiethnic-cohort-of-women-findings-from-the-study-of-women-s-health-across-the-nation-swan
#20
Amanda A Allshouse, Nanette Santoro, Robin Green, Jason Y Y Wong, Dawn M Upchurch, Genevieve Neal-Perry, Rebecca C Thurston, Carol A Derby
OBJECTIVES: We investigated whether faith was associated with a difference in time to incident metabolic syndrome (MetS) among midlife Hispanic women vs women of other ethnicities. STUDY DESIGN: The Study of Women's Health Across the Nation (SWAN) is a community-based, longitudinal study of a cohort of midlife women. Social, demographic, psychosocial, anthropometric, medical, and physiological measures, and incident MetS were assessed in near-annual intervals using questionnaires and assays...
June 2018: Maturitas
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