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Gadolinium Brain MRI

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https://www.readbyqxmd.com/read/28416842/-drainage-characteristic-of-the-brain-interstitial-fluid-detected-by-using-fluorescence-and-magnetic-tracer-method
#1
Y Zhao, Y Q Li, H Y Li, Y L Li, L X Liu, L Yuan, S J Zhang, H B Han
OBJECTIVE: Compare the results of molecular diffusion and mass flow in the interstitial space(ISS) displayed by using optical and magnetic probes and study partitioned drainage of the brain interstitial fluid (ISF). METHODS: In the study, 36 male SD rats were randomly divided into fluorescent inspection group (18), magnetic tracer group (18). Then they were divided equally into caudate nucleus (Cn), thalamus (T) and substantia nigra (Sn) subgroup, 6 rats in each subgroup...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28416425/-bilateral-facial-nerve-palsy-associated-with-epstein-barr-virus-infection-in-a-3-year-old-boy
#2
M Grassin, A Rolland, N Leboucq, A Roubertie, F Rivier, P Meyer
Bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. We describe a case of bilateral simultaneous facial nerve palsy associated with Epstein-Barr virus (EBV) infection in a 3-year-old boy. Several symptoms led to the diagnosis of EBV infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with EBV-specific antibodies, lymphocytic meningitis, and a positive blood EBV polymerase chain reaction (9...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28415747/comparison-of-gadolinium-enhanced-mri-and-18fdg-pet-pet-ct-for-the-diagnosis-of-brain-metastases-in-lung-cancer-patients-a-meta-analysis-of-5-prospective-studies
#3
Ye Li, Guanqiao Jin, Danke Su
OBJECTIVE: We undertook this meta-analysis to compare the significance of Gadolinium-enhanced MRI and 18FDG PET/PET-CT for diagnosing brain metastases of lung cancer patients. RESULTS: Five articles comprising 941 patients were included for analysis. The sensitivities with 95% confidence interval for PET/PET-CT and MRI were 0.21 (0.13 - 0.32) and 0.77 (95% CI = 0.60 - 0.89), specificities were 1.00 (0.99 - 1.00) and 0.99 (0.97 - 1.00), and the areas under curve were 0...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409254/pediatric-brain-mri-part-1-basic-techniques
#4
REVIEW
Mai-Lan Ho, Norbert G Campeau, Thang D Ngo, Unni K Udayasankar, Kirk M Welker
Pediatric neuroimaging is a complex and specialized field that uses magnetic resonance (MR) imaging as the workhorse for diagnosis. Standard MR techniques used in adult neuroimaging are suboptimal for imaging in pediatrics because there are significant differences in the child's developing brain. These differences include size, myelination and sulcation. MR protocols need to be tailored to the specific indication and reviewed by the supervising radiologist in real time, and the specialized needs of this population require careful consideration of issues such as scan timing, sequence order, sedation, anesthesia and gadolinium administration...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28392539/headache-caused-by-brain-metastases-of-castration-resistant-prostate-cancer-during-cabazitaxel-therapy
#5
Keitaro Watanabe, Takeo Kosaka, Hiroshi Hongo, Satoshi Tamaki, Mototsugu Oya
We describe the case of a 55-year-old man who underwent four cycles of cabazitaxel therapy for castration-resistant prostate cancer (CRPC). After the fourth cycle of cabazitaxel, the patient experienced severe headaches. Brain gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) revealed multiple brain metastases. A few days later, the patient suffered impaired consciousness that progressed rapidly. The patient was treated for the symptoms of increased intracranial pressure and underwent whole-brain radiation...
April 7, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/28391601/retrospective-evaluation-of-cerebral-tumors-resect-a-clinical-database-of-pre-operative-mri-and-intra-operative-ultrasound-in-low-grade-glioma-surgeries
#6
Yiming Xiao, Maryse Fortin, Geirmund Unsgård, Hassan Rivaz, Ingerid Reinertsen
PURPOSE: The advancement of medical image processing techniques, such as image registration, can effectively help improve the accuracy and efficiency of brain tumor surgeries. However, it is often challenging to validate these techniques with real clinical data due to the rarity of such publicly available repositories. ACQUISITION AND VALIDATION METHODS: Pre-operative magnetic resonance images (MRI), and intra-operative ultrasound (US) scans were acquired from 23 patients with low-grade glioma who underwent surgeries at St...
April 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28387066/calcifying-pseudoneoplasm-of-the-neuraxis-in-direct-continuity-with-a-low-grade-glioma-a-case-report-and-review-of-the-literature
#7
Nayuta Higa, Hideaki Yokoo, Hirofumi Hirano, Hajime Yonezawa, Tatsuki Oyoshi, Yuko Goto, Kazunori Arita
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are presumed to be a non-neoplastic reactive pathology, based on the frequent finding of granulomatous inflammation. To our knowledge, there are few reports of CAPNON in association with a neoplasm. Here, we report the case of a 62-year-old man presenting with headache, which was caused by CAPNON in the left cingulate gyrus. CT scan revealed a calcified mass exhibiting gradual growth and increasing peritumoral edema. MRI showed an intra-axial hypointense mass on T1- and T2-weighted images...
April 7, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28377923/dynamic-susceptibility-contrast-magnetic-resonance-imaging-protocol-of-the-normal-canine-brain
#8
Krystina L Stadler, Anthony P Pease, Elizabeth A Ballegeer
Perfusion magnetic resonance imaging (MRI), specifically dynamic susceptibility MRI (DSC-MRI) is routinely performed as a supplement to conventional MRI in human medicine for patients with intracranial neoplasia and cerebrovascular events. There is minimal data on the use of DSC-MRI in veterinary patients and a DSC-MRI protocol in the veterinary patient has not been described. Sixteen normal dogs, 6 years or older were recruited for this study. The sample population included 11 large dogs (>11 kg) and 5 small dogs (<11 kg)...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28375456/long-term-outcomes-of-allogeneic-haematopoietic-stem-cell-transplantation-for-adult-cerebral-x-linked-adrenoleukodystrophy
#9
Jörn-Sven Kühl, Felipe Suarez, Godfrey T Gillett, Philipp G Hemmati, John A Snowden, Michael Stadler, Giang L Vuong, Patrick Aubourg, Wolfgang Köhler, Renate Arnold
The adult cerebral inflammatory form of X-linked adrenoleukodystrophy is a rapidly progressive neurodegenerative disease, as devastating as childhood cerebral adrenoleukodystrophy. Allogeneic haematopoietic stem cell transplantation has been demonstrated to provide long-term neurological benefits for boys with the childhood cerebral form, but results in adults are sparse and inconclusive. We analysed data from 14 adult males with adult cerebral adrenoleukodystrophy treated with allogeneic haematopoietic stem cell transplantation on a compassionate basis in four European centres...
April 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28362042/gadolinium-contrast-agents-are-they-really-safe
#10
Hana Malikova, Michal Holesta
Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be more easily released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease...
March 28, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28361260/gadolinium-retention-in-the-body-what-we-know-and-what-we-can-do
#11
REVIEW
Enrico Tedeschi, Ferdinando Caranci, Flavio Giordano, Valentina Angelini, Sirio Cocozza, Arturo Brunetti
Gadolinium-based contrast agents (GBCA), widely used in Magnetic Resonance Imaging (MRI) for almost 30 years, were recently shown to be deposited in the brain and to induce persistent T1 shortening in deep gray matter structures in subjects with normal renal function. The aim of the present study is to summarize the evidence derived from the rapidly growing scientific literature on Gadolinium retention in the brain and in the rest of the body. To this end, the original articles that described imaging and pathology findings in humans and animals exposed to GBCA were reviewed...
March 30, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28357495/signal-intensity-change-on-unenhanced-t1-weighted-images-in-dentate-nucleus-and-globus-pallidus-after-multiple-administrations-of-gadoxetate-disodium-an-intraindividual-comparative-study
#12
Giorgio Conte, Lorenzo Preda, Emilia Cocorocchio, Sara Raimondi, Caterina Giannitto, Marta Minotti, Francesca De Piano, Giuseppe Petralia, Pier Francesco Ferrucci, Massimo Bellomi
PURPOSE: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. MATERIALS AND METHODS: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up...
March 29, 2017: European Radiology
https://www.readbyqxmd.com/read/28357166/spontaneous-intracranial-hypotension-presenting-as-a-pseudo-chiari-1
#13
Ali S Haider, Suraj Sulhan, Ian T Watson, Dean Leonard, Eliel N Arrey, Umair Khan, Phu Nguyen, Kennith F Layton
Spontaneous intracranial hypotension (SIH) is classified as a decrease in cerebrospinal fluid (CSF) pressure secondary to a CSF leakage and consequent descent of the brain into the foramen magnum. Diagnosing SIH can be difficult due to its overlapping findings with Arnold-Chiari type 1 Malformation (CM1) where the cerebellar tonsils herniate into the foramen magnum. The similarity of both conditions calls for a more reliable imaging technique to localize the CSF leak which could narrow the differential diagnosis and aid in choosing the correct treatment...
February 16, 2017: Curēus
https://www.readbyqxmd.com/read/28322975/a-polymeric-micelle-magnetic-resonance-imaging-mri-contrast-agent-reveals-blood-brain-barrier-bbb-permeability-for-macromolecules-in-cerebral-ischemia-reperfusion-injury
#14
Kouichi Shiraishi, Zuojun Wang, Daisuke Kokuryo, Ichio Aoki, Masayuki Yokoyama
Blood-brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation. The recombinant human tissue-type plasminogen activator (rtPA) increases the risk of symptomatic intracranial hemorrhages. Recent imaging technologies have advanced our understanding of pathological BBB disorders; however, an ongoing challenge in the pre-"rtPA treatment" stage is the task of developing a rigorous method for hemorrhage-risk assessments...
March 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28306402/the-effect-of-radiation-dose-on-the-onset-and-progression-of-radiation-induced-brain-necrosis-in-the-rat-model
#15
Brad A Hartl, Htet S W Ma, Katherine S Hansen, Julian Perks, Michael S Kent, Ruben C Fragoso, Laura Marcu
PURPOSE: To provide a comprehensive understanding of how the selection of radiation dose affects the temporal and spatial progression of radiation-induced necrosis in the rat model. MATERIALS AND METHODS: Necrosis was induced with a single fraction of radiation exposure, at doses ranging between 20 and 60 Gy, to the right hemisphere of 8-week-old Fischer rats from a linear accelerator. The development and progression of necrosis in the rats was monitored and quantified every other week with T1- and T2-weighted gadolinium contrast-enhanced MRI studies...
March 17, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28301882/infantile-hemangioma-of-the-posterior-fossa-in-a-newborn-early-management-and-long-term-follow-up
#16
Elsa Haine, Annick Sevely, Sergio Boetto, Marie-Bernadette Delisle, Claude Cances
A 21-day-old male infant was admitted with signs of intracranial hypertension. Brain magnetic resonance imaging (MRI) revealed a voluminous mass in the posterior fossa with an intense peripheral enhancement on T1 images with gadolinium. The child was treated secondarily by surgical decompression of the posterior fossa and the lesion was biopsied. The pathological findings indicated infantile hemangioma. Treatment with oral prednisolone was initiated at 3 months, given the lack of tumor involution. Six months after corticotherapy was stopped, repeated MRIs indicated a significant reduction in tumor size and then complete disappearance...
March 16, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28289935/repeated-intravenous-administration-of-gadobutrol-does-not-lead-to-increased-signal-intensity-on-unenhanced-t1-weighted-images-a-voxel-based-whole-brain-analysis
#17
Soenke Langner, Marie-Luise Kromrey, Jens-Peter Kuehn, Matthias Grothe, Martin Domin
OBJECTIVES: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis. METHODS: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#18
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28283598/leptomeningeal-gadolinium-enhancement-across-the-spectrum-of-chronic-neuroinflammatory-diseases
#19
Martina Absinta, Irene C M Cortese, Luisa Vuolo, Govind Nair, Manori P de Alwis, Joan Ohayon, Alessandro Meani, Vittorio Martinelli, Roberta Scotti, Andrea Falini, Bryan R Smith, Avindra Nath, Steven Jacobson, Massimo Filippi, Daniel S Reich
OBJECTIVE: To assess the prevalence and the specificity of leptomeningeal enhancement (LME) on postcontrast T2-fluid-attenuated inversion recovery (FLAIR) MRI in multiple sclerosis (MS) compared to a variety of inflammatory and noninflammatory neurologic conditions assessed in 2 academic research hospitals. METHODS: On 3T postcontrast T2-FLAIR images, the presence of focal gadolinium enhancement was evaluated in the leptomeningeal compartment in 254 people with non-MS neurologic conditions or neurotropic viral infections...
April 11, 2017: Neurology
https://www.readbyqxmd.com/read/28277457/advanced-mri-measures-of-cerebral-perfusion-and-their-clinical-applications
#20
Bryan Lanzman, Jeremy J Heit
Cerebral blood flow measurement by magnetic resonance imaging perfusion (MRP) techniques is broadly applied to patients with acute ischemic stroke, vasospasm following aneurysmal subarachnoid hemorrhage, chronic arterial steno-occlusive disease, cervical atherosclerotic disease, and primary brain neoplasms. MRP may be performed using an exogenous tracer, most commonly gadolinium-based intravenous contrast, or an endogenous tracer, such as arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). Here, we review the technical basis of commonly performed MRP techniques, the interpretation of MRP imaging maps, and how MRP provides valuable clinical information in the triage of patients with cerebral disease...
April 2017: Topics in Magnetic Resonance Imaging: TMRI
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