keyword
https://read.qxmd.com/read/38020329/systematic-review-of-the-use-of-the-6-minute-walk-test-in-measuring-and-improving-prognosis-in-patients-with-ischemic-heart-disease
#21
REVIEW
Andrew Coulshed, David Coulshed, Faraz Pathan
INTRODUCTION: The 6-minute walk test (6MWT) has been used for over 30 years to assess exercise capacity in patients with respiratory disease, and more recently, in those with heart failure. However, despite being a simple and reproducible test of real-world exercise capacity, its use in patients with ischemic heart disease (IHD) is less well accepted. We sought to review systematically the evidence surrounding the 6MWT in IHD. METHODS: We searched the Medline, PubMed, Embase, and Scopus databases for the following key terms: "six minute walk test/6 minute walk test/6MWT" and "angina/coronary artery disease/coronary disease/IHD/ischemic heart disease...
November 2023: CJC open
https://read.qxmd.com/read/37967141/acute-myocardial-infarction-from-a-lower-middle-income-country-a-comprehensive-report-on-performance-measures-and-quality-metrics-using-national-cardiovascular-data-registry
#22
JOURNAL ARTICLE
Farhala Baloch, Ainan Arshad, Sher Muhammad Sethi, Javed M Tai
INTRODUCTION: Epidemic of cardiovascular disease (CVD) is widely projected in South Asian population and estimated to get double in two decades. Ischemic heart disease (IHD) is one of the spectrums of CVD and acute myocardial infarction (AMI) being the common manifestations of IHD. National Cardiovascular Data Registry (NCDR) is a registry data that measure their practices and improve quality of care. In this project we aim to see our performance trends in the care of IHD including AMI patients over two year's period...
2023: PloS One
https://read.qxmd.com/read/37963685/role-of-genetic-polymorphisms-in-clopidogrel-response-variability-a-systematic-review
#23
JOURNAL ARTICLE
Jose Lopez, Justin Mark, Gustavo J Duarte, Mohammed Shaban, Franklin Sosa, Rishabh Mishra, Swati Jain, An Tran, Asma Khizar, Daniel Karpel, Giancarlo Acosta, Miguel Rodriguez-Guerra
INTRODUCTION: Clopidogrel is a P2Y12 inhibitor that has become a mainstay treatment following percutaneous intervention with drug-eluting stent placement to decrease restenosis and its potential complications, including sudden cardiac death and ischaemic strokes in patients with significant vascular disease. AREAS COVERED: As a prodrug, the metabolism and efficacy of clopidogrel are contingent on the presence of wild-type CYP450 (CYP2C19) alleles. Genetic polymorphisms and variants are well known to impair its ability to prevent major adverse cardiovascular events in these patients, with inadequate response rates as high as 30% in previous publications...
November 2023: Open Heart
https://read.qxmd.com/read/37963682/comorbidities-prior-to-out-of-hospital-cardiac-arrest-and-diagnoses-at-discharge-among-survivors
#24
JOURNAL ARTICLE
Nellie Hjärtstam, Araz Rawshani, Gustaf Hellsén, Truls Råmunddal
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) has a dismal prognosis with overall survival around 10%. Previous studies have shown conflicting results regarding the prevalence and significance of comorbidities in OHCA, as well as the underlying causes. Previously, 80% of sudden cardiac arrest have been attributed to coronary artery disease. We studied comorbidities and discharge diagnoses in OHCA in all of Sweden. METHODS: We used the Swedish Registry of Cardiopulmonary Resuscitation, merged with the Inpatient Registry and Outpatient Registry to identify patients with OHCA from 2010 to 2020 and to collect all their comorbidities as well as discharge diagnoses (among those admitted to hospital)...
November 2023: Open Heart
https://read.qxmd.com/read/37949621/the-canadian-study-of-arterial-inflammation-in-patients-with-diabetes-and-recent-vascular-events-evaluation-of-colchicine-effectiveness-cadence-protocol-for-a-randomised-double-blind-placebo-controlled-trial
#25
JOURNAL ARTICLE
Kevin Emery Boczar, Sheojung Shin, Robert A deKemp, Dar Dowlatshahi, Anahita Tavoosi, Christiane Wiefels, Peter Liu, Heather Lochnan, Paul A MacPherson, Aun Yeong Chong, Carlos Torres, Eugene Leung, Ahmed Tawakol, Ali Ahmadi, Linda Garrard, Chantal Lefebvre, Cathy Kelly, Poppy MacPhee, Everad Tilokee, Paolo Raggi, George A Wells, Rob Beanlands
BACKGROUND: Inflammation is a key mediator in the development and progression of the atherosclerotic disease process as well as its resultant complications, like myocardial infarction (MI), stroke and cardiovascular (CV) death, and is emerging as a novel treatment target. Trials involving anti-inflammatory medications have demonstrated outcome benefit in patients with known CV disease. In this regard, colchicine appears to hold great promise. However, there are potential drawbacks to colchicine use, as some studies have identified an increased risk of infection, and a non-significant trend for increased all-cause mortality...
November 10, 2023: BMJ Open
https://read.qxmd.com/read/37930348/contemporary-risk-factors-associated-with-ischaemic-heart-disease-in-central-south-africa-a-single-centre-study
#26
JOURNAL ARTICLE
Michelle Butler, Lezelle Botes, Stephen Brown, Francis Smit
BACKGROUND: Deaths from non-communicable diseases have increased in sub-Saharan Africa over the years, with limited data on coronary artery disease (CAD) and the risk factors thereof. The objective of this study was to investigate modifiable and non-modifiable risk factors in central South Africa in patients with CAD. METHODS: Patients with angiographically confirmed CAD who were evaluated in the catheterisation laboratory for the first time over a two-year period (2016 - 2017) were included...
November 6, 2023: Cardiovascular Journal of Africa
https://read.qxmd.com/read/37926912/sex-specific-presentation-care-and-clinical-events-in-individuals-admitted-with-nstemi-the-acvc-eapci-eorp-nstemi-registry-of-the-european-society-of-cardiology
#27
JOURNAL ARTICLE
Ramesh Nadarajah, Peter Ludman, Cécile Laroche, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milasinovic, Chris P Gale
BACKGROUND: Women have historically been disadvantaged in terms of care and outcomes for NSTEMI. We describe patterns of presentation, care, and outcomes for NSTEMI by sex in a contemporary and geographically diverse cohort. METHODS: Prospective cohort study including 2947 patients (907 women, 2040 men) with Type I NSTEMI from 287 centres in 59 countries, stratified by sex. Quality of care was evaluated based on 12 guideline-recommended care interventions. The all-or-none scoring composite performance measure was used to define receipt of optimal care...
October 31, 2023: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/37914540/sodium-glucose-cotransporter-2-inhibitors-in-south-australia-the-magic-before-the-fame
#28
JOURNAL ARTICLE
Jia Yong Tan, Derek P Chew, Kristina Lambrakis, Kathryn D Tiver, Emmanuel S Gnanamanickam, Chellalakshmi Muthuranjan, Stephen N Stranks, Carmine G De Pasquale
BACKGROUND: Recent clinical trials have demonstrated that sodium-glucose cotransporter 2 inhibitors (SGLT2i), which were previously only indicated in treatment of type 2 diabetes mellitus (T2DM), can markedly reduce heart failure hospitalisation (HFH), with less striking potential reductions in acute coronary syndromes and cardiac arrhythmias. To evaluate the impact of SGLT2i on cardiovascular outcomes in real-world practice, we performed a retrospective cohort analysis on South Australian (SA) data...
November 2023: Heart, Lung & Circulation
https://read.qxmd.com/read/37875127/complications-in-patients-with-cardiogenic-shock-on-veno-arterial-extracorporeal-membrane-oxygenation-therapy-distribution-and-relevance-results-from-an-international-multicentre-cohort-study
#29
JOURNAL ARTICLE
Benedikt N Beer, Caroline Kellner, Alina Goßling, Jonas Sundermeyer, Lisa Besch, Angela Dettling, Paulus Kirchhof, Stefan Blankenberg, Alexander M Bernhardt, Stefan Brunner, Pascal Colson, Dennis Eckner, Derk Frank, Ingo Eitel, Norbert Frey, Matthias Eden, Tobias Graf, Danny Kupka, Ulf Landmesser, Nicolas Majunke, Octavian Maniuc, Sven Möbius-Winkler, David A Morrow, Marc Mourad, Curt Noel, Peter Nordbeck, Martin Orban, Federico Pappalardo, Sandeep M Patel, Matthias Pauschinger, Hermann Reichenspurner, P Christian Schulze, Robert H G Schwinger, Antonia Wechsler, Carsten Skurk, Holger Thiele, Anubodh S Varshney, Can Martin Sag, Jannis Krais, Dirk Westermann, Benedikt Schrage
BACKGROUND: VA-ECMO restores circulation and tissue oxygenation in cardiogenic shock (CS) patients, but can also lead to complications. OBJECTIVES: To quantify VA-ECMO complications and analyse their association with overall survival as well as favourable neurological outcome (CPC 1 + 2). METHODS: All-comer patients with CS treated with VA-ECMO were retrospectively enrolled from 16 centres in 4 countries (2005-2019). Neurological, bleeding and ischaemic adverse events (AEs) were considered...
October 24, 2023: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/37850354/impact-of-hypertriglyceridaemia-on-cardiovascular-mortality-according-to-low-density-lipoprotein-cholesterol-in-a-15-6-million-population
#30
JOURNAL ARTICLE
Hyung-Bok Park, Reza Arsanjani, Sung-Jin Hong, Jee-Jeon Yi, Sang-Wook Yi
AIMS: To assess the association between triglyceride (TG) levels and cardiovascular disease (CVD) mortality concerning low-density lipoprotein cholesterol (LDL-C) and age in the general population. METHODS AND RESULTS: From the Korean National Health Insurance Service database, 15,672,028 participants aged 18-99 who underwent routine health examinations were followed up for CVD mortality. Hazard ratios (HRs) for CVD mortality were calculated using Cox models after adjusting for various confounders...
October 18, 2023: European Journal of Preventive Cardiology
https://read.qxmd.com/read/37849625/racial-ethnic-disparities-in-the-alzheimer-s-disease-link-with-cardio-and-cerebrovascular-diseases-based-on-hawaii-medicare-data
#31
JOURNAL ARTICLE
Chathura Siriwardhana, Enrique Carrazana, Kore Liow, John J Chen
BACKGROUND: There is an expanding body of literature implicating heart disease and stroke as risk factors for Alzheimer's disease (AD). Hawaii is one of the six majority-minority states in the United States and has significant racial health disparities. The Native-Hawaiians/Pacific-Islander (NHPI) population is well-known as a high-risk group for a variety of disease conditions. OBJECTIVE: We explored the association of cardiovascular disease with AD development based on the Hawaii Medicare data, focusing on racial disparities...
2023: JAD Reports
https://read.qxmd.com/read/37817566/changes-in-proteinuria-and-the-associated-risks-of-ischemic-heart-disease-acute-myocardial-infarction-and-angina-pectoris-in-korean-population
#32
JOURNAL ARTICLE
Sung Keun Park, Ju Young Jung, Min-Ho Kim, Chang-Mo Oh, Eunhee Ha, Eun Hye Yang, Hyo Choon Lee, Soonsu Shin, Woo Yeon Hwang, Sangho Lee, So Youn Shin, Jae-Hong Ryoo
OBJECTIVES: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease. METHODS: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative → negative; resolved: proteinuria ≥1+ → negative; incident: negative → proteinuria ≥1+; persistent: proteinuria ≥1+ → proteinuria ≥1+)...
2023: Epidemiology and Health
https://read.qxmd.com/read/37813562/cognitive-impairment-and-outcomes-in-older-adults-with-non-st-elevation-acute-coronary-syndrome
#33
JOURNAL ARTICLE
Valerie Josephine Dirjayanto, Mohammad Alkhalil, John Dodson, Gregory Mills, Graziella Pompei, Francesca Rubino, Vijay Kunadian
OBJECTIVE: This study aimed to explore the prognostic impact of cognitive impairment on the long-term risk of major adverse cardiovascular events (MACEs) in older patients with non-ST-elevation acute coronary syndrome (NSTEACS) undergoing invasive treatment. METHODS: Patients aged ≥75 years with NSTEACS undergoing an invasive strategy were included in the multicentre prospective study (NCT01933581). Montreal Cognitive Assessment was used to evaluate cognitive status at baseline (scores ≥26 classified as normal, <26 as cognitive impairment)...
October 9, 2023: Heart
https://read.qxmd.com/read/37763799/analysis-of-the-association-between-retinal-artery-occlusion-and-acute-ischaemic-stroke-st-elevation-myocardial-infarction-and-risk-factors-in-hungarian-patients
#34
JOURNAL ARTICLE
Szabolcs Balla, Attila Vajas, Orsolya Pásztor, Anikó Rentka, Balázs Lukucz, Márta Kasza, Attila Nagy, Mariann Fodor, Valéria Nagy
Background and Objectives : We aimed to analyse data on retinal artery occlusion (RAO) patients to explore correlations with acute ischaemic stroke (AIS), ST-elevation myocardial infarction (STEMI), and cardio/cerebrovascular comorbidities. Patients and Methods : Our retrospective cohort study included 169 RAO and 169 age- and gender-matched control patients. We examined the association of AIS, STEMI, and related comorbidities such as hypertension (HT), type 1 and type 2 diabetes (T1DM and T2DM, respectively), hyperlipidaemia, and ischaemic heart disease (IHD) with RAO...
September 18, 2023: Medicina
https://read.qxmd.com/read/37740450/effects-of-renin-angiotensin-system-blockers-on-outcomes-from-covid-19-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#35
JOURNAL ARTICLE
Matthew M Y Lee, Toru Kondo, Ross T Campbell, Mark C Petrie, Naveed Sattar, Scott D Solomon, Muthiah Vaduganathan, Pardeep S Jhund, John J V McMurray
BACKGROUND AND AIMS: Randomized controlled trials (RCTs) have assessed the effects of renin-angiotensin system (RAS) blockers in adults with coronavirus disease 2019 (COVID-19). This meta-analysis provides estimates of the safety and efficacy of treatment with (vs. without) RAS blockers from these trials. METHODS: PubMed, Web of Science, and ClinicalTrials.gov were searched (1 March-12 April 2023). Event/patient numbers were extracted, comparing angiotensin-converting enzyme (ACE) inhibitor/angiotensin-receptor blocker (ARB) treatment with no treatment, for the outcomes: intensive care unit (ICU) admission, mechanical ventilation, vasopressor use, acute kidney injury (AKI), renal replacement therapy (RRT), acute myocardial infarction, stroke/transient ischaemic attack, heart failure, thromboembolic events, and all-cause death...
January 5, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
https://read.qxmd.com/read/37714678/plasma-type-i-collagen-%C3%AE-1-chain-in-relation-to-coronary-artery-disease-findings-from-a-prospective-population-based-cohort-and-an-acute-myocardial-infarction-prospective-cohort-in-sweden
#36
JOURNAL ARTICLE
Filip Hammaréus, Lennart Nilsson, Kwok-Leung Ong, Margareta Kristenson, Karin Festin, Anna K Lundberg, Rosanna W S Chung, Eva Swahn, Joakim Alfredsson, Signe Holm Nielsen, Lena Jonasson
OBJECTIVES: To investigate the association between type I collagen α1 chain (COL1α1) levels and coronary artery disease (CAD) by using absolute quantification in plasma. Also, to investigate the correlates of COL1α1 to clinical characteristics and circulating markers of collagen metabolism. DESIGN: Life conditions, Stress and Health (LSH) study: prospective cohort study, here with a nested case-control design.Assessing Platelet Activity in Coronary Heart Disease (APACHE) study: prospective cohort study...
September 15, 2023: BMJ Open
https://read.qxmd.com/read/37712510/association-of-stress-hyperglycemia-ratio-with-in-hospital-new-onset-atrial-fibrillation-and-long-term-outcomes-in-patients-with-acute-myocardial-infarction
#37
JOURNAL ARTICLE
Jiachen Luo, Zhiqiang Li, Xiaoming Qin, Xingxu Zhang, Xiangdong Liu, Wenming Zhang, Wei Xu, Baoxin Liu, Yidong Wei
AIMS: To investigate the predictive value and prognostic impact of stress hyperglycemia ratio (SHR) for new-onset atrial fibrillation (NOAF) complicating acute myocardial infarction (AMI). MATERIALS AND METHODS: This retrospective study included 2145 AMI patients without AF history between February 2014 and March 2018. SHR was calculated using fasting blood glucose (mmol/L)/[1.59*HbA1c (%)-2.59]. The association between SHR and post-MI NOAF was assessed with multivariable logistic regression analyses...
September 15, 2023: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/37673458/association-between-diseases-of-despair-and-atherosclerotic-cardiovascular-disease-among-insured-adults-in-the-usa-a-retrospective-cohort-study-from-2017-to-2021
#38
JOURNAL ARTICLE
Matthew Nudy, Kathleen Galper, Daniel R George, Brent A Williams, Jennifer L Kraschnewski, Lawrence Sinoway, Emily Brignone
OBJECTIVES: To assess associations between diseases of despair (DoD) and incident atherosclerotic cardiovascular disease (ASCVD) among insured adults in the USA. DESIGN: Retrospective cohort study. SETTING: Highmark insurance claims data in the USA from 2017 to 2021. PARTICIPANTS: Adults with at least 10 months of continuous insurance enrolment, no record of ASCVD in the 2016 baseline year and no missing data on study variables...
September 6, 2023: BMJ Open
https://read.qxmd.com/read/37662584/spontaneous-coronary-artery-dissection-with-leucoencephalopathy-associated-with-thrombospondin-type-1-domain-containing-1-gene-mutation-a-case-report
#39
Gotabhaya Ranasinghe, Rasika Sovis, Sajeev Shellvacumar, Vajira H W Dissanayake
BACKGROUND: Spontaneous coronary artery dissection (SCAD) is increasingly diagnosed as one of the infrequent causes of acute coronary syndrome. Almost no cause was identified in half of the cases. Here, we report a rare case of spontaneous coronary artery dissection with leucoencephalopathy (SCADLE) associated with a mutation of the thrombospondin Type 1 domain containing 1 (THSD1) gene. CASE SUMMARY: A 36-year-old lady who presented with ischaemic type chest pain for 4 h duration and found to have anterior ST elevation myocardial infarction...
September 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37645441/safety-profiles-of-methylphenidate-amphetamine-and-atomoxetine-analysis-of-spontaneous-reports-submitted-to-the-food-and-drug-administration-adverse-event-reporting-system
#40
JOURNAL ARTICLE
Wei Wei, Li Chen, Hui Zhou, Jinfeng Liu, Yue Zhang, Shiyu Feng, Yingtao Bai, Yanen Leng, En Chang, Liang Huang
Background: Methylphenidate, atomoxetine, and Amphetamine are the three most commonly used medications approved by the United States Food and Drug Administration (FDA) for the treatment of attention deficit/hyperactivity disorder (ADHD). However, a comprehensive analysis of their safety profiles across various age groups and genders in real-world contexts has yet to be conducted. In this study, a pharmacovigilance analysis was performed using the FDA Adverse Event Reporting System (FAERS) database to examine differences in adverse events between methylphenidate, atomoxetine, and Amphetamine...
2023: Frontiers in Pharmacology
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