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Eleonora Cianflone, Iolanda Aquila, Mariangela Scalise, Pina Marotta, Michele Torella, Bernardo Nadal-Ginard, Daniele Torella
Ischemic Heart Disease (IHD) remains the developed world's number one killer. The improved survival from Acute Myocardial Infarction (AMI) and the progressive aging of western population brought to an increased incidence of chronic Heart Failure (HF), which assumed epidemic proportions nowadays. Except for heart transplantation, all treatments for HF should be considered palliative because none of the current therapy can reverse myocardial degeneration responsible for HF syndrome. To stop the HF epidemic will ultimately require protocols to reduce the progressive cardiomyocyte (CM) loss and to foster their regeneration...
June 3, 2018: Cell Cycle
Iñaki Galán, Lorena Simón, Elena Boldo, Cristina Ortiz, María José Medrano, Rafael Fernández-Cuenca, Cristina Linares, Roberto Pastor-Barriuso
INTRODUCTION AND OBJECTIVES: To evaluate the impact of 2 smoking bans enacted in 2006 (partial ban) and 2011 (comprehensive ban) on hospitalizations for cardiovascular disease in the Spanish adult population. METHODS: The study was performed in 14 provinces in Spain. Hospital admission records were collected for acute myocardial infarction (AMI), ischemic heart disease (IHD), and cerebrovascular disease (CVD) in patients aged ≥ 18 years from 2003 through 2012...
April 16, 2018: Revista Española de Cardiología
George V Dous, Angela C Grigos, Richard Grodman
Although the prognostic value of a positive troponin in an acute stroke patient is still uncertain, it is a commonly encountered clinical situation given that Ischemic Heart Disease (IHD) and cerebrovascular disease (CVD) frequently co-exist in the same patient and share similar risk factors. Our objectives in this review are to (1) identify the biologic relationship between acute cerebrovascular stroke and elevated troponin levels, (2) determine the pathophysiologic differences between positive troponin in the setting of acute stroke versus acute myocardial infarction (AMI), and (3) examine whether positive troponin in the setting of acute stroke has prognostic significance...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
Annette S H Schultz, Lindsey Dahl, Elizabeth McGibbon, R Jarvis Brownlie, Catherine Cook, Basem Elbarouni, Alan Katz, Thang Nguyen, Jo Ann Sawatzky, Moneca Sinclaire, Karen Throndson, Randy Fransoo
OBJECTIVES: To investigate recipient characteristics and rates of index angiography among First Nations (FN) and non-FN populations in Manitoba, Canada. SETTING: Population-based, secondary analysis of provincial administrative health data. PARTICIPANTS: All adults 18 years or older who received an index angiogram between 2000/2001 and 2008/2009. PRIMARY AND SECONDARY OUTCOME MEASURES: (1) Descriptive statistics for age, sex, income quintile by rural and urban residency and Charlson Comorbidity Index for FN and non-FN recipients...
March 25, 2018: BMJ Open
Davide Lazzeroni, Paolo Coruzzi
Worldwide, more than 7 million people experience acute myocardial infarction (AMI) every year (1), and although substantial reduction in mortality has been obtained in recent decades, one-year mortality rates are still in the range of 10%. Among patients who survive AMI, 20% suffer a second cardiovascular event in the first year and approximately 50% of major coronary events occur in those with a previous hospital discharge diagnosis of AMI (2). Despite the evidence that lifestyle changes and risk factors management strongly improve long-term prognosis, preventive care post-AMI remains sub-optimal...
February 19, 2018: Minerva Cardioangiologica
Mandreker Bahall, Katija Khan
BACKGROUND: Outcomes following acute myocardial infarction (AMI) may result in death, increased morbidity, and change in quality of life (QOL). This study explores health-related QOL of first-time patients following AMI. METHODS: This cross-sectional study used a sample of patients with first-time AMI experienced between April 2011 and March 2015 at a tertiary health institution. Recruited patients belonged to different post-AMI periods: 2-10 weeks, 5-22 months, and > 22 months to 4 years post AMI...
February 13, 2018: Health and Quality of Life Outcomes
M Bahall, T Seemungal, G Legall
BACKGROUND: The relative importance of coronary artery disease (CAD) risk varies globally. The aim of this study was to determine CAD risk factors for acute myocardial infarction (AMI) among patients in public health care institutions in Trinidad using a case-control type study design. METHODS: The sample comprised 251 AMI patients hospitalized between March 1, 2011 and April 30, 2012 and 464 age- and sex-matched non-AMI patients with no terminal or life-threatening illness and who did not undergo treatment for CAD...
January 19, 2018: BMC Public Health
Matilde Winther-Jensen, Christian Hassager, Jens Flensted Lassen, Lars Køber, Christian Torp-Pedersen, Steen Møller Hansen, Freddy Lippert, Erika Frischknecht Christensen, Kristian Kragholm, Jesper Kjaergaard
Aims: For patients surviving out-of-hospital cardiac arrest (OHCA) with a shockable rhythm, implantable cardioverter defibrillator (ICD) is recommended for non-reversible causes of arrest. We aimed to determine factors associated with implantation of ICD and survival in patients surviving non-AMI OHCA in a nationwide register covering all OHCAs in Denmark. Methods and results: We identified 36 950 OHCAs between 2001 and 2012, 1700 of whom were ICD naïve, ≥18 years, of non-AMI cardiac aetiology and surviving until discharge...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Greg Scott, Jeff J Clawson, Isabel Gardett, Meghan Broadbent, Nathan Williams, Conrad Fivaz, Gigi Marshall, Tracey Barron, Christopher Olola
OBJECTIVE: Chest pain is one of the most common reasons people seek emergency care-and one of the most critical. In the United States, chest pain is the second most common reason for emergency department (ED) visits. A patient's primary complaint of "chest pain" may reflect a broad range of underlying causes; therefore, it is important that emergency medical service (EMS) agencies gain a thorough understanding of these cases, beginning with the initial management of chest pain in the 9-1-1 center...
July 2017: Prehospital Emergency Care
Sanja Bijelović, Nataša Dragić, Milorad Bijelović, Mila Kovačević, Marija Jevtić, Olivera Ninkovic Mrđenovački
BACKGROUND: The aim of this study has been to examine the association between climate conditions (CC) and hospital admissions for the subcategories of cardiovascular diseases (CVD), according to patients' age. MATERIAL AND METHODS: From January 2010 through December 2011, the daily number of hospital admissions for angina pectoris (AP), essential hypertension (EH), acute myocardial infarction (AMI) and ischemic heart diseases (IHD) for adults (19-64 years old) and the elderly (≥ 65 years old), as well as for the CC (N = 728 days) was collected for multivariate Poisson regression analysis, confounding with season and weekends...
March 24, 2017: Medycyna Pracy
Hualiang Lin, Tao Liu, Jianpeng Xiao, Weilin Zeng, Lingchuan Guo, Xing Li, Yanjun Xu, Yonghui Zhang, Jen Jen Chang, Michael G Vaughn, Zhengmin Min Qian, Wenjun Ma
Hourly peak concentration may capture health effects of ambient fine particulate matter pollution (PM2.5) better than daily averages. We examined the associations of hourly peak concentration of PM2.5 with cardiovascular mortality in Guangzhou, China. We obtained daily data on cardiovascular mortality and hourly PM2.5 concentrations in Guangzhou from 19 January 2013 through 30 June 2015. Generalized additive models were applied to evaluate the associations with adjustment for potential confounding factors. Significant associations were found between hourly peak concentrations of PM2...
May 2017: Journal of Exposure Science & Environmental Epidemiology
Mieraf Taddesse Tolla, Ole Frithjof Norheim, Solomon Tessema Memirie, Senbeta Guteta Abdisa, Awel Ababulgu, Degu Jerene, Melanie Bertram, Kirsten Strand, Stéphane Verguet, Kjell Arne Johansson
BACKGROUND: The coverage of prevention and treatment strategies for ischemic heart disease and stroke is very low in Ethiopia. In view of Ethiopia's meager healthcare budget, it is important to identify the most cost-effective interventions for further scale-up. This paper's objective is to assess cost-effectiveness of prevention and treatment of ischemic heart disease (IHD) and stroke in an Ethiopian setting. METHODS: Fifteen single interventions and sixteen intervention packages were assessed from a healthcare provider perspective...
2016: Cost Effectiveness and Resource Allocation: C/E
Aolin Wang, Onyebuchi A Arah, Jussi Kauhanen, Niklas Krause
OBJECTIVES: This study aimed to disentangle the interplay between occupational physical activity (OPA) and leisure-time physical activity (LTPA) in affecting cardiovascular health by examining: (i) interactions between OPA and LTPA and their combined effect on 20-year incidence of acute myocardial infarction (AMI) and (ii) the effect of OPA on AMI that is mediated through LTPA. METHODS: We analyzed data on 1891 men, aged 42-60 years at baseline, from the prospective Kuopio Ischemic Heart Disease Risk Factor Study...
September 1, 2016: Scandinavian Journal of Work, Environment & Health
Vidmantas Vaičiulis, Ričardas Radišauskas, Rūta Ustinavičienė, Gintarė Kalinienė, Abdonas Tamošiūnas
The aim of this study was to evaluate the associations among morbidity of acute myocardial infarction (AMI) and mortality from ischemic heart disease (IHD) with heliogeophysical factors among the Kaunas population. The study population was stratified into three age categories: 25-54, 55-64, and ≥65 years. In this study, solar flares (SF), solar proton fluences (SPF), and geomagnetic activity (GMA) were employed as heliogeophysical factors and used Poisson regression and two methods of time series modeling (lag and lead)...
September 2016: Environmental Science and Pollution Research International
Roland Chetty, Andrew Ross
BACKGROUND: Incidence and prevalence of non-communicable diseases, including ischaemic heart disease (IHD) and associated acute myocardial infarction (AMI), are increasing in South Africa. Local studies are needed as contextual factors, such as healthcare systems, gender and ethnicity, may affect presentation and management. In AMI, reviews on time between onset of chest pain and initiation of urgent treatment are useful, as delays in initiation of thrombolytic treatment significantly increase morbidity and mortality...
March 30, 2016: African Journal of Primary Health Care & Family Medicine
A Safa, H R Rashidinejad, M Khalili, S Dabiri, M Nemati, M M Mohammadi, A Jafarzadeh
Recruitment of leukocytes is one of the earliest events in the pathogenesis of ischemic heart disease (IHD) and chemokines play an important role in the migration of these cells into the inflammation sites. The aim of this study was to evaluate the CXCL10, CCL20 and CCL22 levels and the single nucleotide polymorphisms (SNPs) rs4508917, rs6749704 and rs4359426 in chemokine genes in patients with IHD to clarify any association. A total of 300 patients with IHD as having acute myocardial infarction (AMI; n=100), stable angina (SA; n=100) or unstable angina (UA; n=100) and 100 healthy subjects as a control group were enrolled to study...
July 2016: Cytokine
Aolin Wang, Onyebuchi A Arah, Jussi Kauhanen, Niklas Krause
OBJECTIVES: It remains unclear whether different types of shift work impose similar risks for cardiovascular events in middle-aged workers, especially those with pre-existing ischaemic heart disease (IHD). This study investigated the relations between different shift types and incident acute myocardial infarction (AMI) among men with and without pre-existing IHD, respectively. METHODS: We analysed data on 1891 men, aged 42-60 years at baseline, in the prospective Kuopio Ischemic Heart Disease Risk Factor Study cohort, using Cox proportional hazard models with adjustment for demographic, biological, behavioural and psychosocial job factors...
September 2016: Occupational and Environmental Medicine
Peter Morfeld, Kenneth A Mundt, Linda D Dell, Tom Sorahan, Robert J McCunney
Epidemiological studies have demonstrated associations between airborne environmental particle exposure and cardiac disease and mortality; however, few have examined such effects from poorly soluble particles of low toxicity such as manufactured carbon black (CB) particles in the work place. We combined standardised mortality ratio (SMR) and Cox proportional hazards results from cohort studies of US, UK and German CB production workers. Under a common protocol, we analysed mortality from all causes, heart disease (HD), ischemic heart disease (IHD) and acute myocardial infarction (AMI)...
March 9, 2016: International Journal of Environmental Research and Public Health
Rasmus Strandmark, Johan Herlitz, Christer Axelsson, Andreas Claesson, Anders Bremer, Thomas Karlsson, Maria Jimenez-Herrera, Annica Ravn-Fischer
BACKGROUND: The aim of this study was a) To identify predictors of the use of aspirin in the pre-hospital setting in acute myocardial infarction (AMI) and b) To analyze whether the use of any of the recommended medications was associated with outcome. METHODS: All patients with a final diagnosis of AMI, transported by the Emergency Medical Services (EMS) and admitted to the coronary care unit at Sahlgrenska University Hospital in Gothenburg, Sweden, in 2009-2011, were included...
2015: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Thuan-Quoc Thach, Sarah M McGhee, Jason C So, June Chau, Eric K P Chan, Chit-Ming Wong, Anthony J Hedley
OBJECTIVES: To examine trends in deaths for conditions associated with secondhand smoke exposure over the years prior to and following the implementation of a smoke-free policy in Hong Kong. DESIGN: Time-series study. SETTING: Death registration data from Hong Kong Special Administrative Region (SAR) Government Census and Statistics Department. PARTICIPANTS: All deaths registered from 1 January 2001 to 31 December 2011...
November 2016: Tobacco Control
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