Mehrdad Hashemi, Mehrnaz Razzazan, Maryam Bagheri, Saba Asadi, Behdokht Jamali, Maryam Khalafi, Abolfazl Azimi, Sepideh Rad, Mitra Behroozaghdam, Noushin Nabavi, Mohsen Rashidi, Farshid Dehkhoda, Afshin Taheriazam, Maliheh Entezari
AMP-activated protein kinase (AMPK) signaling has a versatile role in Osteosarcoma (OS), an aggressive bone malignancy with a poor prognosis, particularly in cases that have metastasized or recurred. This review explores the regulatory mechanisms, functional roles, and therapeutic applications of AMPK signaling in OS. It focuses on the molecular activation of AMPK and its interactions with cellular processes like proliferation, apoptosis, and metabolism. The uncertain role of AMPK in cancer is also discussed, highlighting its potential as both a tumor suppressor and a contributor to carcinogenesis...
October 4, 2023: Pathology, Research and Practice