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Resveratrol AND AMPK

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https://www.readbyqxmd.com/read/29242624/plant-derived-compounds-strigolactone-gr24-and-pinosylvin-activate-sirt1-and-enhance-glucose-uptake-in-rat-skeletal-muscle-cells
#1
Shalem Modi, Nagendra Yaluri, Tarja Kokkola, Markku Laakso
Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue. We hypothesised that the novel plant-derived compounds, strigolactone and pinosylvin, beneficially enhance SIRT1 function, insulin signalling, glucose uptake, and mitochondrial biogenesis in skeletal muscle cells...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235249/anticancer-effects-of-resveratrol-in-canine-hemangiosarcoma-cell-lines
#2
A Carlson, K S Alderete, M K O Grant, D M Seelig, L C Sharkey, B N M Zordoky
Hemangiosarcoma (HSA) is a highly malignant tumour with aggressive biological behaviour. HSAs are more common in dogs than other domestic animals. The median survival time of dogs with HSA remains short, even with chemotherapy and surgery. Therefore, there is a critical need to improve the adjuvant chemotherapeutic regimens to improve clinical outcomes in dogs with HSA. Resveratrol has been shown to possess strong anti-proliferative and/or pro-apoptotic properties in human cancer cell lines. Nevertheless, the potential anticancer effects of resveratrol have not been reported in canine HSAs...
December 13, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29213353/resveratrol-prevents-ros-induced-apoptosis-in-high-glucose-treated-retinal-capillary-endothelial-cells-via-the-activation-of-ampk-sirt1-pgc-1%C3%AE-pathway
#3
Jun Li, Songping Yu, Jia Ying, Tianyan Shi, Peipei Wang
Resveratrol (RSV) is used as a protective therapy against diabetic retinopathy. However, the mechanism(s) underlying this protective effect has not been fully elucidated. Bovine retinal capillary endothelial cells (BRECs), an in vitro model, were used to investigate the mechanism of RSV. Our results showed that high glucose induced significant cellular apoptosis in BRECs, which was accompanied by increased intracellular levels of reactive oxygen species (ROS) and cleaved caspase-3. The glucose-induced apoptosis and ROS elevation were both inhibited by RSV...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29208771/advanced-iron-overload-cardiomyopathy-in-a-genetic-murine-model-is-rescued-by-resveratrol-therapy
#4
Subhash K Das, Pavel Zhabyeyev, Ratnadeep Basu, Vaibhav B Patel, Jason R B Dyck, Zamaneh Kassiri, Gavin Y Oudit
Iron-overload cardiomyopathy is prevalent on a worldwide basis and is a major co-morbidity in patients with genetic hemochromatosis and secondary iron overload. Therapies are limited in part due to lack of a valid pre-clinical model, which recapitulates advanced iron-overload cardiomyopathy. Male hemojuvelin knockout (HJVKO) mice, which lack hemojuvelin (HJV), a bone morphogenetic co-receptor protein required for hepcidin expression and systemic iron homeostasis, were fed a high iron diet starting at 4 weeks of age for a duration of 1 year...
December 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29202102/combinatorial-treatment-with-natural-compounds-in-prostate-cancer-inhibits-prostate-tumor-growth-and-leads-to-key-modulations-of-cancer-cell-metabolism
#5
Alessia Lodi, Achinto Saha, Xiyuan Lu, Bo Wang, Enrique Sentandreu, Meghan Collins, Mikhail G Kolonin, John DiGiovanni, Stefano Tiziani
High-throughput screening of a natural compound library was performed to identify the most efficacious combinatorial treatment on prostate cancer. Ursolic acid, curcumin and resveratrol were selected for further analyses and administered in vivo via the diet, either alone or in combination, in a mouse allograft model of prostate cancer. All possible combinations of these natural compounds produced synergistic effects on tumor size and weight, as predicted in the screens. A subsequent untargeted metabolomics and metabolic flux analysis using isotopically labeled glutamine indicated that the compound combinations modulated glutamine metabolism...
2017: NPJ Precision Oncology
https://www.readbyqxmd.com/read/29189984/the-role-of-resveratrol-on-skeletal-muscle-cell-differentiation-and-myotube-hypertrophy-during-glucose-restriction
#6
Hannah F Dugdale, David C Hughes, Robert Allan, Colleen S Deane, Christopher R Coxon, James P Morton, Claire E Stewart, Adam P Sharples
Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that resveratrol treatment would improve muscle cell differentiation and myotube hypertrophy in differentiating C2C12 myoblasts and mature myotubes during GR. Glucose restriction at 0.6 g/L (3.3 mM) blocked differentiation and myotube hypertrophy versus high-glucose (4...
November 30, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29172079/design-syntheses-and-lipid-accumulation-inhibitory-activities-of-novel-resveratrol-mimics
#7
Chanjuan Li, Bao Cheng, Sai Fang, Huihao Zhou, Qiong Gu, Jun Xu
Hispidine was initially discovered from Ficus Hispida for cardiovascular protection. In this paper, hispidine derivatives, which contain a novel resveratrol-like scaffold, have been designed, synthesized, and assayed as agents against lipid accumulations in 3T3-L1 pre-adipocytes. Six hispidine derivatives have the activity of reducing TG in 3T3-L1 adipocytes in dosage-dependent manner. The most active compound can reduce the lipid accumulation up to 78.4% at 10 μM qPCR and Western blotting results demonstrate that the two most active compounds inhibit both lipodenesis and adipogenesis in 3T3-L1 cells through (1) increasing the phosphorylations of AMPK and ACC, promoting SIRT1 expression...
November 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29171745/retracted-resveratrol-inhibits-oesophageal-adenocarcinoma-cell-proliferation-via-amp-activated-protein-kinase-signaling
#8
(no author information available yet)
Retraction: Retracted:Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling Asian Pacific Journal of Cancer Prevention (APJCP) has retracted the article titled “Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling”(1) for reason of having duplicated contents brought to the attention of APJCP’s editorial office by the following email content: “Dear Editors of Gastroenterology and Hepatology, Acta Pharmacologica Sinica, Asian Pac J Cancer Prev, Clinical and Experimental Hypertension, I write to you from the editorial office of PLOS ONE to inform you of concerns related to duplicated content in articles published by your journals...
November 24, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29164657/resveratrol-protects-leydig-cells-from-nicotine-induced-oxidative-damage-through-enhanced-autophagy
#9
Shengxian Liu, Qinyu Sun, Zhaomin Li
Some studies have revealed that nicotine can damage the male reproductive system through various ways including oxidative stress, which is a primary factor in the pathogenesis of male infertility. The strong antioxidative capacity of resveratrol has been demonstrated previously, but its role in the context of male reproduction remains inconclusive. To explore the biological role of resveratrol in protecting male reproductive function and the potential underlying mechanism, nicotine-induced Leydig cells were used as a cell model of oxidative damage...
November 22, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29130531/acute-hypoxic-preconditioning-prevents-palmitic-acid-induced-cardiomyocyte-apoptosis-via-switching-metabolic-glut4-glucose-pathway-back-to-cd36-fatty-acid-dependent
#10
Yeh-Peng Chen, Wei-Wen Kuo, Rathinasamy Baskaran, Cecilia-Hsuan Day, Ray-Jade Chen, Su-Ying Wen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Chia-Hua Kuo, Chih-Yang Huang
Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myocardial cell damage leads to an imbalance of energy metabolism, and many studies have indicated that short-term hypoxia during myocardial cell injury has a protective effect. In our previous animal studies, we found that short-term hypoxia in the heart has a protective effect, but long-term hypoxia increases myocardial cell injury. Palmitic acid (PA)-treated H9c2 cardiomyoblasts and neonatal rat ventricle cardiomyocytes were used to simulate hyperlipidemia model, which suppress cluster of differentiation 36 (CD36) and activate glucose transporter type 4 (GLUT4)...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29115429/resveratrol-mediated-apoptosis-in-renal-cell-carcinoma-via-the-p53-amp%C3%A2-activated-protein-kinase-mammalian-target-of-rapamycin-autophagy-signaling-pathway
#11
Qingjun Liu, Qiang Fang, Shiqi Ji, Zhixing Han, Wenlong Cheng, Haijian Zhang
Resveratrol, known as phytoalexin, is a natural compound. Clinical studies have revealed that resveratrol has a variety of effects including anti‑inflammatory, antivirus and tumor suppressor activities. It has been reported that it may serve an important role in renal cell carcinoma (RCC) however, the molecular mechanism underlying resveratrol‑induced apoptosis in RCC is still unclear. The aim of the present study was to determine whether resveratrol could suppress RCC progression. Analysis of apoptosis demonstrated that resveratrol may act as a RCC suppressor in a dose‑ and time‑dependent manner...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29070475/-effect-of-resveratrol-on-forelimb-grip-strength-and-myofibril-structure-in-aged-rats
#12
Zhi-Yin Liao, Ke-Xiang Zhao, Qian Xiao
OBJECTIVE: To observe the effect of resveratrol on muscle mass, forelimb grip strength, myofibril structure and AMPK/sirt1 pathway in skeletal muscles of aged rats. METHODS: Twenty aged (25 months old) SD rats were randomly divided into aged control group and resveratrol treatment group (10 in each group) with 10 young (6 months old) rats served as the young control group. In resveratrol treatment group, the rats were treated with resveratrol (mixed in chow) for 6 weeks...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29067115/advanced-glycation-end-products-and-lipopolysaccharides-stimulate-interleukin-6-secretion-via-the-rage-tlr4-nf-%C3%AE%C2%BAb-ros-pathways-and-resveratrol-attenuates-these-inflammatory-responses-in-mouse-macrophages
#13
Ayaka Ohtsu, Yui Shibutani, Kotomi Seno, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
Macrophages are essential for regulating the physiology of pregnancy; however, excessive inflammatory responses to macrophages, induced by infection and/or endogenous danger signals, may potentially result in complications during pregnancy. Advanced glycation end-products (AGE) and lipopolysaccharides (LPS) are known to induce inflammation and are associated with adverse developmental outcomes. The aim of the present study was to examine the effect of AGE and LPS on cytokines in the J774 murine macrophage cell line and the potential effect of resveratrol on AGE- and LPS-induced inflammation in macrophages...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29036449/resveratrol-attenuates-bone-cancer-pain-through-regulating-the-expression-levels-of-asic3-and-activating-cell-autophagy
#14
Haili Zhu, Jieqiong Ding, Ji Wu, Tingting Liu, Jing Liang, Qiong Tang, Ming Jiao
Bone cancer pain (BCP) is one of the most common pains in patients with malignant cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the increasing evidence both have shown that acid-sensing ion channels 3 (ASIC3) is an important protein in the pathological pain state in some pain models. We hypothesized that the expression change of ASIC3 might be one of the factors related to BCP. In this study, we established the BCP model through intrathecally injecting rat mammary gland carcinoma cells (MRMT-1) into the left tibia of Sprague-Dawley female rats, and found that the BCP rats showed bone destruction, increased mechanical pain sensitivities and up-regulated ASIC3 protein expression levels in L4-L6 dorsal root ganglion...
November 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29027961/dosis-facit-sanitatem-concentration-dependent-effects-of-resveratrol-on-mitochondria
#15
REVIEW
Corina T Madreiter-Sokolowski, Armin A Sokolowski, Wolfgang F Graier
The naturally occurring polyphenol, resveratrol (RSV), is known for a broad range of actions. These include a positive impact on lifespan and health, but also pro-apoptotic anti-cancer properties. Interestingly, cell culture experiments have revealed a strong impact of RSV on mitochondrial function. The compound was demonstrated to affect mitochondrial respiration, structure and mass of mitochondria as well as mitochondrial membrane potential and, ultimately, mitochondria-associated cell death pathways. Notably, the mitochondrial effects of RSV show a very strict and remarkable concentration dependency: At low concentrations, RSV (<50 μM) fosters cellular antioxidant defense mechanisms, activates AMP-activated protein kinase (AMPK)- and sirtuin 1 (SIRT1)-linked pathways and enhances mitochondrial network formation...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28989083/resveratrol-activation-of-ampk-dependent-pathways-is-neuroprotective-in-human-neural-stem-cells-against-amyloid-beta-induced-inflammation-and-oxidative-stress
#16
Ming-Chang Chiang, Christopher J Nicol, Yi-Chuan Cheng
Alzheimer's disease (AD) is a neurodegenerative disorder with progressive memory loss resulting in dementia. Amyloid-beta (Aβ) peptides play a critical role in the pathogenesis of this disease, and are thought to promote inflammation and oxidative stress leading to neurodegeneration in the neocortex and hippocampus of the AD brains. AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis, and cell survival in response to inflammation and oxidative stress. However, the neuroprotective mechanisms by which AMPK achieves these beneficial effects in human neural stem cells (hNSCs) exposed to Aβ is still not well understood...
October 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28956002/maternal-resveratrol-intake-during-lactation-attenuates-hepatic-triglyceride-and-fatty-acid-synthesis-in-adult-male-rat-offspring
#17
Masato Tanaka, Tomomi Kita, Shojiro Yamasaki, Tae Kawahara, Yukako Ueno, Mai Yamada, Yuuka Mukai, Shin Sato, Masaaki Kurasaki, Takeshi Saito
Resveratrol (3,5,4-trihydroxystilbene) is a natural polyphenolic compound found in grapes and red wine and has been shown to exert protective effects on the liver preventing lipid accumulation induced by a high-fat diet. However, no studies have shown that the nutritional resveratrol intake by the parental generation has modified lipogenesis in an adult offspring. The aim of this study was to investigate whether maternal resveratrol intake during lactation affects lipogenesis in adult male rat offspring, and if it does, what is the molecular mechanistic basis...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28929674/-molecular-mechanisms-of-autophagy-in-regulating-renal-aging-and-interventional-effects-of-chinese-herbal-medicine
#18
REVIEW
Yue Tu, Wei Sun, Di-Ping Chen, Yi-Gang Wan, Wei Wu, Jian Yao
Aging is the gradual functional recession of the living tissues or organs caused by a variety of genetic and environmental factors together. Autophagy is a process of degrading cytoplasmic components mediated by lysosomes in eukaryotic cells. Kidney is a typical target organ of aging. Autophagy regulates renal aging. Decrease in autophagy can accelerate renal aging,whereas,increase in autophagy can delay renal aging. During the process of regulating renal aging,the mammalian target of rapamycin (mTOR) and its related signaling pathways including the adenosine monophosphate activated protein kinase (AMPK)/mTOR,the phosphatidylinositol 3-kinase (PI3K)/ serine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in renal aging...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28819881/resveratrol-induces-apoptosis-and-inhibits-adipogenesis-by-stimulating-the-sirt1-ampk%C3%AE-foxo1-signalling-pathway-in-bovine-intramuscular-adipocytes
#19
Xiaomu Liu, Hongbo Zhao, Qing Jin, Wei You, Haijian Cheng, Yifan Liu, Enliang Song, Guifen Liu, Xiuwen Tan, Xianglun Zhang, Fachun Wan
Sirtuin type 1 (SIRTl) and AMP-activated protein kinase (AMPK) play important roles in regulating energy metabolism, cell proliferation and differentiation, ageing, apoptosis, and metabolism. The effect of 100, 200, and 400 μm Resveratrol (RES), an activator of SIRT1, on apoptosis of bovine intramuscular adipocytes was investigated by nuclear staining, flow cytometry, quantitative real-time polymerase chain reaction, and western blotting. Results show that RES inhibited adipogenesis, decreased cell viability, and increased apoptotic rates in a dose-dependent way...
August 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28761044/resveratrol-reverses-the-warburg-effect-by-targeting-the-pyruvate-dehydrogenase-complex-in-colon-cancer-cells
#20
Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, Jerry W Shay, Xavier Coumoul, Robert Barouki, Chantal Benelli, Laurence Huc, Sylvie Bortoli
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth. However, the rapid metabolism of resveratrol strongly limits its bioavailability. The molecular mechanisms sustaining the potential biological activity of low doses of resveratrol has not been extensively studied and, thus, needs better characterization. Here, we show that resveratrol (10 µM, 48 hr) induces both a cell growth arrest and a metabolic reprogramming in colon cancer cells...
July 31, 2017: Scientific Reports
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