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Resveratrol AND AMPK

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https://www.readbyqxmd.com/read/27873458/resveratrol-enhances-brown-adipocyte-formation-and-function-by-activating-amp-activated-protein-kinase-ampk-%C3%AE-1-in-mice-fed-high-fat-diet
#1
Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B D Rodgers, Qingyan Jiang, Michael V Dodson, Min Du
SCOPE: Enhancing the formation and function of brown adipose tissue (BAT) increases thermogenesis and hence reduces obesity. Thus, we investigate the effects of resveratrol (Resv) on brown adipocyte formation and function in mouse interscapular BAT (iBAT). METHODS AND RESULTS: CD1 mice and stromal vascular cells (SVCs) isolated from iBAT were treated with Resv. Expression of brown adipogenic and thermogenic markers, and involvement of AMP-activated protein kinase (AMPK)α1 were assessed...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27836811/sirt1-ampk-crosstalk-is-involved-in-high-glucose-dependent-impairment-of-insulin-responsiveness-in-primary-rat-podocytes
#2
Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowski
Growing evidence indicates that in diabetes, high glucose concentrations affect podocyte metabolism and function. The crucial pathological feature of type 2 diabetes mellitus and metabolic syndrome is insulin resistance, often developed as a result of dysregulation of nutrient-responsible systems and disturbance of cellular homeostasis under diabetic conditions. Here, we report the involvement of the reciprocal interplay between deacetylase SIRT1 and protein kinase AMPK in podocyte high glucose-induced abolition of insulin-dependent glucose uptake, manifesting insulin resistance...
November 9, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27789328/resveratrol-increases-microrna-130a-expression-to-promote-angiogenesis-and-improve-heart-functions-in-mice-after-myocardial-infarction
#3
Guanmin Tang, Lei Peng, Gang Qian, Shijun Wang, Huilin Hu, Xiaoping Zhang, Guojie Song, Ming Yao, Changlin Zhai
BACKGROUND: Resveratrol, a polyphenol of natural compounds, has beneficial cardiovascular effects. Increased expression of miR-130a has been reported to attenuate cardiac remodeling after myocardial infarction (MI). We hypothesized that resveratrol via an miR-130a-dependent mechanism promotes angiogenesis and improves heart functions in mice after MI. METHODS: The MI model was established in mice by ligation of left anterior descending coronary artery. The expression of miR-130a was examined by RT-qPCR...
October 24, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27788262/resveratrol-reverses-functional-chagas-heart-disease-in-mice
#4
Glaucia Vilar-Pereira, Vitor C Carneiro, Hilton Mata-Santos, Amanda R R Vicentino, Isalira P Ramos, Naira L L Giarola, Daniel F Feijó, José R Meyer-Fernandes, Heitor A Paula-Neto, Emiliano Medei, Marcelo T Bozza, Joseli Lannes-Vieira, Claudia N Paiva
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27669292/yap-inhibition-by-resveratrol-via-activation-of-ampk-enhances-the-sensitivity-of-pancreatic-cancer-cells-to-gemcitabine
#5
Zhengdong Jiang, Xin Chen, Ke Chen, Liankang Sun, Luping Gao, Cancan Zhou, Meng Lei, Wanxing Duan, Zheng Wang, Qingyong Ma, Jiguang Ma
Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both in vitro and in vivo. Aberrant expression of YAP has been reported to activate multiple growth-regulatory pathways and confer anti-apoptotic abilities to many cancer cells. However, the role of resveratrol in YES-activated protein (YAP) expression and that of YAP in pancreatic cancer cells' response to gemcitabine resistance remain elusive. In this study, we found that resveratrol suppressed the proliferation and cloning ability and induced the apoptosis of pancreatic cancer cells...
2016: Nutrients
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#6
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27504055/2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-glucoside-isolated-from-polygoni-multiflori-ameliorates-the-development-of-periodontitis
#7
Yu-Tang Chin, Meng-Ti Hsieh, Chi-Yu Lin, Po-Jan Kuo, Yu-Chen S H Yang, Ya-Jung Shih, Hsuan-Yu Lai, Guei-Yun Cheng, Heng-Yuan Tang, Chen-Chen Lee, Sheng-Yang Lee, Ching-Chiung Wang, Hung-Yun Lin, Earl Fu, Jacqueline Whang-Peng, Leroy F Liu
Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27494711/cilostazol-modulates-autophagic-degradation-of-%C3%AE-amyloid-peptide-via-sirt1-coupled-lkb1-ampk%C3%AE-signaling-in-neuronal-cells
#8
So Youn Park, Hye Rin Lee, Won Suk Lee, Hwa Kyoung Shin, Hye Young Kim, Ki Whan Hong, Chi Dae Kim
A neuroprotective role of autophagy mediates the degradation of β-amyloid peptide (Aβ) in Alzheimer's disease (AD). The previous study showed cilostazol modulates autophagy by increasing beclin1, Atg5 and LC3-II expressions, and depletes intracellular Aβ accumulation. This study elucidated the mechanisms through which cilostazol modulates the autophagic degradation of Aβ in neurons. In N2a cells, cilostazol (10-30 μM), significantly increased the expression of P-AMPKα (Thr 172) and downstream P-ACC (acetyl-CoA carboxylase) (Ser 79) as did resveratrol (SIRT1 activator), or AICAR (AMPK activator), which were blocked by KT5720, compound C (AMPK inhibitor), or sirtinol...
2016: PloS One
https://www.readbyqxmd.com/read/27488452/resveratrol-inhibits-renal-interstitial-fibrosis-in-diabetic-nephropathy-by-regulating-ampk-nox4-ros-pathway
#9
Ting He, Jiachuan Xiong, Ling Nie, Yanlin Yu, Xu Guan, Xinli Xu, Tangli Xiao, Ke Yang, Liang Liu, Daohai Zhang, Yunjian Huang, Jingbo Zhang, Junping Wang, Kumar Sharma, Jinghong Zhao
: Renal interstitial fibrosis is a major pathologic feature of diabetic nephropathy, while the pathogenesis and therapeutic interventions of diabetic renal interstitial fibrosis are not well established. In this study, we first demonstrated that high glucose could induce renal fibroblast (NRK-49F) cell proliferation and activation to myofibroblasts, accompanied by a significant increase in the intracellular levels of reactive oxygen species (ROS) derived from nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4)...
August 4, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27454290/p53-coordinates-decidual-sestrin-2-ampk-mtorc1-signaling-to-govern-parturition-timing
#10
Wenbo Deng, Jeeyeon Cha, Jia Yuan, Hirofumi Haraguchi, Amanda Bartos, Emma Leishman, Benoit Viollet, Heather B Bradshaw, Yasushi Hirota, Sudhansu K Dey
Inflammation and oxidative stress are known risk factors for preterm birth (PTB); however, the mechanisms and pathways that influence this condition are not fully described. Previously, we showed that mTORC1 signaling is increased in mice harboring a uterine-specific deletion of transformation-related protein 53 (p53d/d mice), which exhibit premature decidual senescence that triggers spontaneous and inflammation-induced PTB. Treatment with the mTORC1 inhibitor rapamycin reduced the incidence of PTB in the p53d/d mice...
August 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27398147/resveratrol-attenuated-estrogen-deficient-induced-cardiac-dysfunction-role-of-ampk-sirt1-and-mitochondrial-function
#11
Zijun Meng, Hongjiang Jing, Lu Gan, Hua Li, Bingde Luo
Large epidemiological studies suggest that there are important differences in the incidence and severity of a wide variety of cardiac diseases, between premenopausal and menopausal women. Recently, it has been demonstrated that resveratrol may has similar function as estrogen. However, whether resveratrol replacement could mimic estrogen to protect heart in ovariectomized mice remains completely unknown. Firstly, the present study has used OVX/CAL model to investigate the effect of RSV on ischemic heart. Echocardiography analysis revealed that RSV administration significantly improved cardiac contractile function in estrogen-deficient mice...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27382348/resveratrol-attenuates-lipopolysaccharide-induced-dysfunction-of-blood-brain-barrier-in-endothelial-cells-via-ampk-activation
#12
Min Hu, Bo Liu
Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions, strictly regulates paracellular permeability to maintain an optimal extracellular environment for brain homeostasis. The aim of this study was to elucidate the effects of resveratrol and the role of AMPK in BBB dysfunction induced by lipopolysaccharide (LPS). Exposure of human brain microvascular endothelial cells (HBMECs) to LPS (1 µg/ml) for 4 to 24 hours week dramatically increased the permeability of the BBB in parallel with lowered expression levels of occluding and claudin-5, which are essential to maintain tight junctions in HBMECs...
July 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27372854/oocyte-activation-and-latent-hiv-1-reactivation-ampk-as-a-common-mechanism-of-action-linking-the-beginnings-of-life-and-the-potential-eradication-of-hiv-1
#13
Jahahreeh Finley
In all mammalian species studied to date, the initiation of oocyte activation is orchestrated through alterations in intracellular calcium (Ca(2+)) signaling. Upon sperm binding to the oocyte plasma membrane, a sperm-associated phospholipase C (PLC) isoform, PLC zeta (PLCζ), is released into the oocyte cytoplasm. PLCζ hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to produce diacylglycerol (DAG), which activates protein kinase C (PKC), and inositol 1,4,5-trisphosphate (IP3), which induces the release of Ca(2+) from endoplasmic reticulum (ER) Ca(2+) stores...
August 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27344038/therapy-with-resveratrol-attenuates-obesity-associated-allergic-airway-inflammation-in-mice
#14
Diana Majolli André, Marina Ciarallo Calixto, Carolina Sollon, Eduardo Costa Alexandre, Luiz O Leiria, Natalia Tobar, Gabriel Forato Anhê, Edson Antunes
Obesity and insulin resistance have been associated with deterioration in asthma outcomes. High oxidative stress and deficient activation of AMP-activated protein kinase (AMPK) have emerged as important regulators linking insulin resistance and inflammation. This study aimed to evaluate the effects of resveratrol on obesity-associated allergic pulmonary inflammation. Male C57/Bl6 mice fed with high-fat diet to induce obesity (obese group) or standard-chow diet (lean group) were treated or not with resveratrol (100mg/kg/day, two weeks)...
September 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27332935/resveratrol-cardioprotection-against-myocardial-ischemia-reperfusion-injury-involves-upregulation-of-adiponectin-levels-and-multimerization-in-type-2-diabetic-mice
#15
Qiang Yang, Hai-Chang Wang, Yi Liu, Chao Gao, Lu Sun, Ling Tao
Downregulation of adiponectin (APN) multimerization is significantly correlated with the aggravation of myocardial ischemia/reperfusion (MI/R) injury in Type 2 diabetes mellitus (T2DM). Resveratrol (RSV) upregulates APN multimerization in adipocytes, but whether RSV improves endogenous APN multimerization and thus attenuates MI/R injury in T2DM mice has never been investigated. T2DM mice were treated with 10 mg/kg RSV daily for 3 weeks, followed by 30 min of myocardial ischemia and 3 h or 24 h of reperfusion...
June 20, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27285995/anti-breast-cancer-potential-of-quercetin-via-the-akt-ampk-mammalian-target-of-rapamycin-mtor-signaling-cascade
#16
Amilcar Rivera Rivera, Linette Castillo-Pichardo, Yamil Gerena, Suranganie Dharmawardhane
The Akt/adenosine monophosphate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has emerged as a critical signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth. Thus, dysregulation of this pathway contributes to the development of metabolic disorders such as obesity, type 2diabetes, and cancer. We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells...
2016: PloS One
https://www.readbyqxmd.com/read/27276511/metformin-and-resveratrol-inhibit-drp1-mediated-mitochondrial-fission-and-prevent-er-stress-associated-nlrp3-inflammasome-activation-in-the-adipose-tissue-of-diabetic-mice
#17
Aiyun Li, Shuihong Zhang, Jia Li, Kang Liu, Fang Huang, Baolin Liu
OBJECTIVE: This study was designed to investigate the hypothesis that metformin and resveratrol exhibited the same effect on inhibition of NLRP3 inflammasome activation with regulation of AMPK in adipose tissue exposed to high glucose. METHODS: To induce adipose tissue dysfunction, we treated epididymal adipose tissue of mice or differentiated 3T3-L1 adipocytes with high glucose (33 mM) for 24 h. Meanwhile, mice were injected with streptozotocin STZ to induce diabetes and followed by oral administration of metformin (200 mg/kg), resveratrol (50 mg/kg) or ER stress inhibitor TUDCA (50 mg/kg) for 7 days...
October 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27190265/brief-communication-sir-2-1-dependent-lifespan-extension-of-caenorhabditis-elegans-by-oxyresveratrol-and-resveratrol
#18
Jiyun Lee, Gayeung Kwon, Jieun Park, Jeong-Keun Kim, Young-Hee Lim
Resveratrol (RES) has been studied for its effects on the lifespan extension of Caenorhabditis elegans, but controversy still remains on its mechanism related with SIR-2. In this study, longevity assay was performed to confirm SIR-2-dependent lifespan extension of C. elgeans with RES and oxyresveratrol (OXY), an isomer of hydroxylated RES using loss-of-function mutants of C. elegans including sir-2.1 mutant. The results showed that OXY and RES significantly (P < 0.05) extended the lifespan of C. elegans compared with the control...
October 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27156686/resveratrol-attenuates-monocyte-to-macrophage-differentiation-and-associated-inflammation-via-modulation-of-intracellular-gsh-homeostasis-relevance-in-atherosclerosis
#19
Sathish Babu Vasamsetti, Santosh Karnewar, Raja Gopoju, Paradesi Naidu Gollavilli, Sai Ram Narra, Jerald Mahesh Kumar, Srigiridhar Kotamraju
Monocyte-to-macrophage differentiation promotes an inflammatory environment within the arterial vessel wall that causes a mal-adaptive immune response, which contributes to the progression of atheromatous plaque formation. In the current study, we show that resveratrol, a well-known antioxidant, dose-dependently attenuated phorbol myristate acetate (PMA)-induced monocyte-to-macrophage differentiation, as measured by cell adhesion, increase in cell size, and scavenger receptor expression in THP-1 monocytes. Also, resveratrol significantly inhibited PMA-induced pro-inflammatory cytokine/chemokine and matrix metalloprotease (MMP-9) production...
July 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27149559/resveratrol-via-activation-of-lkb1-ampk-signaling-suppresses-oxidative-stress-to-prevent-endothelial-dysfunction-in-diabetic-mice
#20
Min Hu, Bo Liu
BACKGROUND: Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. Whether resveratrol via activation of AMPK improves endothelial dysfunction in diabetes remains unknown. Here, we reported that activation of AMPK is required for resveratrol-induced improvement of endothelial function in diabetic mice. METHODS: AMPK phosphorylation and activity, productions of reactive oxygen species, endothelium-dependent/independent relaxation were determined in vitro or in vivo...
2016: Clinical and Experimental Hypertension: CHE
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