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Resveratrol AND AMPK

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https://www.readbyqxmd.com/read/29904891/%C3%AE-viniferin-activates-autophagic-apoptosis-and-cell-death-by-reducing-glucocorticoid-receptor-expression-in-castration-resistant-prostate-cancer-cells
#1
Kejun Cheng, Xi Liu, Lu Chen, Jian-Min Lv, Fa-Jun Qu, Xiu-Wu Pan, Lin Li, Xin-Gang Cui, Yi Gao, Dan-Feng Xu
Prostate cancer (PCa) is one of the most commonly diagnosed urological malignancies. However, there are limited therapies for PCa patients who develop biochemical recurrence after androgen deprivation therapy (ADT). In the present study, we investigated the therapeutic efficacy and mechanism of α-Viniferin (KCV), an oligostilbene of trimeric resveratrol, against human PCa cells and found that it markedly inhibited the proliferation of LNCaP, DU145, and PC-3 cancer cells in a time- and dose-dependent manner, and had a strong cytotoxicity in non-androgen-dependent PCa cells...
June 15, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29896258/resveratrol-provides-benefits-in-mice-with-type-ii-diabetes-induced-chronic-renal-failure-through-ampk-signaling-pathway
#2
Haiyan Guo, Linyun Zhang
Type II diabetes-induced ischemic injuries are known to lead to the rapid degeneration of the kidneys as a result of chronic renal failure. Chronic renal failure is a condition, which typically manifests with symptoms including cardiovascular system and left ventricular hypertrophy, atherosclerosis as well as arterial and aortic stiffness. Resveratrol is a multifunctional compound that has been reported to produce beneficial outcomes for patients with type-II diabetes due to prevention of oxidative stress and apoptosis...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895790/amp-activated-protein-kinase-as-a-reprogramming-strategy-for-hypertension-and-kidney-disease-of-developmental-origin
#3
REVIEW
You-Lin Tain, Chien-Ning Hsu
Suboptimal early-life conditions affect the developing kidney, resulting in long-term programming effects, namely renal programming. Adverse renal programming increases the risk for developing hypertension and kidney disease in adulthood. Conversely, reprogramming is a strategy aimed at reversing the programming processes in early life. AMP-activated protein kinase (AMPK) plays a key role in normal renal physiology and the pathogenesis of hypertension and kidney disease. This review discusses the regulation of AMPK in the kidney and provides hypothetical mechanisms linking AMPK to renal programming...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29894715/resveratrol-ameliorates-disorders-of-mitochondrial-biogenesis-and-dynamics-in-a-rat-chronic-ocular-hypertension-model
#4
Xi Zhang, Yifan Feng, Yuping Wang, Jing Wang, Danni Xiang, Weiran Niu, Fei Yuan
AIMS: To explore the roles of mitochondrial biogenesis and dynamics in both RGC-5 cells apoptosis and rat retinal damage induced by elevated pressure and their involvement in resveratrol (RSV)-induced cell protection. MATERIALS AND METHODS: The chronic ocular hypertension (COH) model was established in rats by injecting superparamagnetic iron oxide into anterior chamber. The RGC-5 cells were incubated under ambient and elevated pressure (70 mm Hg) respectively...
June 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29857913/facilitation-of-hippocampal-long-term-potentiation-and-reactivation-of-latent-hiv-1-via-ampk-activation-common-mechanism-of-action-linking-learning-memory-and-the-potential-eradication-of-hiv-1
#5
Jahahreeh Finley
Learning and memory are generally considered the behavioral correlates of long-term potentiation (LTP), a form of synaptic plasticity associated with a persistent and long-lasting increase in synaptic strength. Repetitive stimulation of excitatory synapses in the hippocampal CA1 region leads to release and binding of glutamate to the glutamate receptors AMPAR and NMDAR located on pyramidal neurons. Activation of AMPARs facilitates Na+ influx, postsynaptic depolarization, NMDAR-mediated Ca2+ influx, and activation of several intracellular mechanisms that characterize LTP, including increased AMPAR synthesis, ROS production, and ER Ca2+ release...
July 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29788929/resveratrol-induces-autophagy-dependent-apoptosis-in-hl-60-cells
#6
Yingying Fan, Jen-Fu Chiu, Jing Liu, Yan Deng, Cheng Xu, Jun Zhang, Guanwu Li
BACKGROUND: All known mechanisms of apoptosis induced by resveratrol act through cell cycle arrest and changes in mitochondrial membrane potential. It is currently unknown whether resveratrol-induced apoptosis is associated with other physiological processes, such as autophagy. METHODS: Apoptosis-related markers involved in the intrinsic and extrinsic apoptotic pathways, and autophagic markers were detected by using western blotting and immunofluorescence. Mitochondrial membrane potential was assayed by flow cytometry...
May 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29788824/activation-of-ampk-in-human-placental-explants-impairs-mitochondrial-function-and-cellular-metabolism
#7
Daphne Landau, Maricela Haghiac, Judi Minium, Yelenna Skomorovska-Prokvolit, Virtu Calabuig-Navarro, Perrie O'Tierney-Ginn
OBJECTIVE: Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor whose phosphorylation increases energy production. We sought to evaluate the placenta-specific effect of AMPK activation on the handling of nutrients required for fetal development. METHODS: Explants were isolated from term placenta of 29 women (pregravid body mass index: 29.1 ± 9.9 kg/m2 ) and incubated for 24 hours with 0 to 100 µmol/L resveratrol or 0 to 1 mmol/L of 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29723857/resveratrol-modulates-apoptosis-and-autophagy-induced-by-high-glucose-and-palmitate-in-cardiac-cells
#8
Kui Xu, Xiu-Fen Liu, Zhi-Qiang Ke, Qing Yao, Shuang Guo, Chao Liu
BACKGROUND/AIMS: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects in various cardiovascular diseases. This study investigated if resveratrol protected cardiac cells by modulating apoptosis and autophagy in the context of diabetes. METHODS: H9c2 cardiac myoblast cells were exposed to high glucose combined with palmitate. Autophagy was evaluated by estimating LC3-II/I ratio, P62 protein levels, and LC3 fluorescent puncta...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29663499/resveratrol-inhibits-the-proliferation-and-induces-the-apoptosis-in-ovarian-cancer-cells-via-inhibiting-glycolysis-and-targeting-ampk-mtor-signaling-pathway
#9
Yu Liu, Lin Tong, Yan Luo, Xin Li, Gaowen Chen, Yifeng Wang
Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, and targeting aerobic glycolysis becomes a promising therapeutic approach for cancer. Here we reported that a small polyphenol resveratrol exhibited profound anti-tumor efficacy on human ovarian cancer. Resveratrol markedly inhibited the proliferation, migration, and invasion of A2780 and SKOV3 ovarian cancer cells, while impaired glycolysis, and induced apoptosis in these cells. Exposure to resveratrol increased the expression and activation of AMPK and Caspase 3, and decreased the expression and activation of AMPK downstream kinase mTOR...
July 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29554499/resveratrol-improves-glucose-uptake-in-insulin-resistant-adipocytes-via-sirt1
#10
Sifan Chen, Zhongliang Zhao, Liangru Ke, Zilun Li, Wenxue Li, Zili Zhang, Ying Zhou, Xiang Feng, Wei Zhu
Insulin resistance serves as "common soil" for promoting the development of metabolic diseases; however, the precise pathological factors leading to insulin resistance are not well clarified. Resveratrol (Res) is a natural polyphenolic compound with anti-inflammatory and antioxidative effects. However, effects and mechanisms of Res on glucose metabolism in adipocytes remain largely unknown. In this study, we show Res treatment significantly increases glucose uptake in insulin-resistant 3T3-L1 adipocytes in vitro...
May 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29524400/ampk-activation-by-pterostilbene-contributes-to-suppression-of-hepatic-gluconeogenic-gene-expression-and-glucose-production-in-h4iie-cells
#11
Guang Ren, Agnes M Rimando, Suresh T Mathews
Pterostilbene, a bioactive component of blueberries and grapes, shows structural similarity to resveratrol, and exhibits antioxidant, anti-inflammatory, anti-cancer, hypoglycemic, and cholesterol lowering effects. Recent evidence indicates that pterostilbene is an agonist of the nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPAR-α). Since PPAR-α agonists induce peroxisomal proliferation and fatty acid oxidation, we examined gene expression of acyl CoA oxidase (ACO) and carnitine palmitoyl transferase-1 (CPT-1)...
April 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29514131/potential-of-resveratrol-in-mitigating-metabolic-disturbances-induced-by-ethanol
#12
REVIEW
Tomasz Szkudelski, Katarzyna Szkudelska
Alcohol abuse is associated with numerous health problems, including metabolic disturbances and liver damage. Therefore, different compounds are continuously being tested to evaluate their potential effectiveness in reducing these harmful changes. Animal studies clearly show that resveratrol is capable of ameliorating some consequences of ethanol ingestion. Resveratrol is a naturally occurring diphenolic compound having pleiotropic, health-promoting properties. Its beneficial action have been also demonstrated in animal models with ethanol-induced metabolic disturbances and liver injury...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29510506/resveratrol-inhibits-porcine-intestinal-glucose-and-alanine-transport-potential-roles-of-na%C3%A2-%C2%BA-k%C3%A2-%C2%BA-atpase-activity-protein-kinase-a-amp-activated-protein-kinase-and-the-association-of-selected-nutrient-transport-proteins-with-detergent-resistant-membranes
#13
Stefanie Klinger, Gerhard Breves
BACKGROUND: Beneficial effects of Resveratrol (RSV) have been demonstrated, including effects on transporters and channels. However, little is known about how RSV influences intestinal transport. The aim of this study was to further characterize the effects of RSV on intestinal transport and the respective mechanisms. METHODS: Porcine jejunum and ileum were incubated with RSV (300 µM, 30 min) in Ussing chambers (functional studies) and tissue bathes (detection of protein expression, phosphorylation, association with detergent resistant membranes (DRMs))...
March 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29494287/resveratrol-regulates-blood-pressure-by-enhancing-ampk-signaling-to-downregulate-a-rac1-derived-nadph-oxidase-in-the-central-nervous-system
#14
Tung-Chen Yeh, Ching-Sen Shin, Hsin-Hung Chen, Chi-Cheng Lai, Gwo-Ching Sun, Ching-Jiunn Tseng, Pei-Wen Cheng
Resveratrol is a polyphenol with pleiotropic effects against oxidative damage that has been widely implicated in the lowering of hypertension risk. The purpose of this study was to determine whether improve NO release in the brain either through the activation of AMPK or reduced Rac1-induced ROS generation, thereby reducing BP in rats with fructose-induced hypertension. The rats were fed with 10% fructose or crestor (rosuvastatin; 1.5 mg/kg/day) and resveratrol (10 mg/kg/day) treatment for 1 week, the systolic blood pressure (SBP) of the rats were measured by tail-cuff method...
March 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29492205/resveratrol-ameliorates-autophagic-flux-to-promote-functional-recovery-in-rats-after-spinal-cord-injury
#15
Peng Wang, Lizhu Jiang, Nian Zhou, Hao Zhou, Huzhe Liu, Wenrui Zhao, Hanxiang Zhang, Xiang Zhang, Zhenming Hu
Resveratrol is known to improve functional recovery after spinal cord injury, but the exact mechanism involved is yet unclear. The aim of this study was to clarify whether resveratrol can exert neuroprotective effects via activating neuronal autophagic flux, in view of the underlying role of the autophagic flux mediated by resveratrol on neuronal apoptosis after spinal cord injury, and identify the role of the liver kinase B1(LKB1)/adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/ p70 ribosomal protein S6 kinase (p70s6k) signal pathway in the autophagic flux mediated by resveratrol...
February 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407880/the-protective-effect-of-resveratrol-on-vascular-aging-by-modulation-of-the-renin-angiotensin-system
#16
Eun Nim Kim, Min Young Kim, Ji Hee Lim, Yaeni Kim, Seok Joon Shin, Cheol Whee Park, Yong-Soo Kim, Yoon Sik Chang, Hye Eun Yoon, Bum Soon Choi
BACKGROUND AND AIMS: This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS: Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and the expression of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), and anti-oxidative enzymes was measured in thoracic aortas of 24-month-old mice...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29393425/ampk-sirt1-p38-mapk-signaling-pathway-regulates-alcohol%C3%A2-induced-neurodegeneration-by-resveratrol
#17
Xinyi Gu, Zhengxu Cai, Ming Cai, Kun Liu, Dan Liu, Qinsong Zhang, Jing Tan, Qiang Ma
Resveratrol has also been approved for use in enhancing plant disease resistance and reducing pesticide use. A number of studies have shown that the disease resistance of crops treated with resveratrol is markedly improved. The aim of the present study was to examine the protective effect of resveratrol against alcohol‑induced neurodegeneration occurred and its association with AMP‑activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/p38 in rats and humans. ELISA, caspase‑3 activity and western blot analyses were employed in the present study...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29336118/resveratrol-potently-counteracts-quercetin-starvation-induced-autophagy-and-sensitizes-hepg2-cancer-cells-to-apoptosis
#18
Sarah Tomas-Hernández, Jordi Blanco, Cristina Rojas, Joel Roca-Martínez, María José Ojeda-Montes, Raúl Beltrán-Debón, Santiago Garcia-Vallvé, Gerard Pujadas, Lluís Arola, Miquel Mulero
SCOPE: Resveratrol (RSV) has been described as a potent antioxidant, antisteatotic, and antitumor compound, and it has also been identified as a potent autophagy inducer. On the other hand, quercetin (QCT) is a dietary flavonoid with known antitumor, anti-inflammatory, and antidiabetic effects. Additionally, QCT increases autophagy. To study the hypothetical synergistic effect of both compounds, we test the combined effect of QCT and RSV on the autophagy process in HepG2 cells. METHODS AND RESULTS: Autophagy is studied by western blotting, real-time RT-PCR, and cellular staining...
March 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29326403/resveratrol-an-nrf2-activator-ameliorates-aging-related-progressive-renal-injury
#19
Eun Nim Kim, Ji Hee Lim, Min Young Kim, Tae Hyun Ban, In-Ae Jang, Hye Eun Yoon, Cheol Whee Park, Yoon Sik Chang, Bum Soon Choi
BACKGROUND: Two important issues in the aging kidney are mitochondrial dysfunction and oxidative stress. An Nrf2 activator, resveratrol, is known to have various effects. Resveratrol may prevent inflammation and oxidative stress by activating Nrf2 and SIRT1 signaling. We examined whether resveratrol could potentially ameliorate the cellular condition, such as renal injury due to cellular oxidative stress and mitochondrial dysfunction caused by aging. METHODS: Male 18-month-old C57BL/6 mice were used...
January 11, 2018: Aging
https://www.readbyqxmd.com/read/29316653/synergistic-association-of-valproate-and-resveratrol-reduces-brain-injury-in-ischemic-stroke
#20
Lara Faggi, Giuseppe Pignataro, Edoardo Parrella, Vanessa Porrini, Antonio Vinciguerra, Pasquale Cepparulo, Ornella Cuomo, Annamaria Lanzillotta, Mariana Mota, Marina Benarese, Paolo Tonin, Lucio Annunziato, PierFranco Spano, Marina Pizzi
Histone deacetylation, together with altered acetylation of NF-κB/RelA, encompassing the K310 residue acetylation, occur during brain ischemia. By restoring the normal acetylation condition, we previously reported that sub-threshold doses of resveratrol and entinostat (MS-275), respectively, an activator of the AMP-activated kinase (AMPK)-sirtuin 1 pathway and an inhibitor of class I histone deacetylases (HDACs), synergistically elicited neuroprotection in a mouse model of ischemic stroke. To improve the translational power of this approach, we investigated the efficacy of MS-275 replacement with valproate, the antiepileptic drug also reported to be a class I HDAC blocker...
January 6, 2018: International Journal of Molecular Sciences
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