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https://www.readbyqxmd.com/read/29314488/fabrication-of-thermosensitive-cyclic-brush-copolymer-with-enhanced-therapeutic-efficacy-for-anticancer-drug-delivery
#1
Xiao-Yan Tu, Chao Meng, Yun-Fei Wang, Li-Wei Ma, Bao-Yan Wang, Jin-Lin He, Pei-Hong Ni, Xiang-Ling Ji, Ming-Zhu Liu, Hua Wei
Adaptation of cyclic brush polymer for drug delivery applications remains largely unexplored. Herein, cyclic brush copolymer of poly(2-hydroxyethyl methacrylate-g-poly(N-isopropylacrylamide-st-N-hydroxyethylacrylamide)) (cb-P(HEMA-g-P(NIPAAm-st-HEAAm))), comprising a cyclic core of PHEMA and thermosensitive brushes of statistical copolymer of P(NIPAAm-st-HEAAm), is designed and synthesized successfully via a graft-from approach using atom transfer free radical polymerization from a cyclic multimacroinitiator...
January 4, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29302531/need-for-revisiting-the-role-of-sexually-transmitted-disease-clinics-in-government-hospitals-in-india
#2
Madhulekha Bhattacharya, Hema Gogia
Introduction: The Government of India provides treatment for sexually transmitted infections (STIs) through government's sexually transmitted disease (STD) clinics with the mandate of providing curative and preventive services for clients in the context of STIs. However, besides the patients suffering from STDs, other clients with problems related to reproductive and sexual health also attend these clinics. This study aimed to assess the profile and treatment-seeking behavior of clients attending STD clinics in government hospitals in India...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29301852/potein-kinase-g-activation-reverses-oxidative-stress-and-restores-osteoblast-function-and-bone-formation-in-male-mice-with-type-1-diabetes
#3
Hema Kalyanaraman, Gerburg Schwaerzer, Ghania Ramdani, Francine Castillo, Brian T Scott, Wolfgang Dillmann, Robert L Sah, Darren E Casteel, Renate B Pilz
Bone loss and fractures are under-recognized complications of type 1 diabetes, and are primarily due to impaired bone formation by osteoblasts. The mechanisms leading to osteoblast dysfunction in diabetes are incompletely understood, but insulin deficiency, poor glycemic control, and hyperglycemia-induced oxidative stress likely contribute. Here we show that insulin promotes osteoblast proliferation and survival via the nitric oxide (NO)/cGMP/protein kinase G (PKG) signal transduction pathway, and that PKG stimulation of Akt provides a positive feedback loop...
January 4, 2018: Diabetes
https://www.readbyqxmd.com/read/29298483/a-metal-protein-attenuating-compound-for-pet-neuroimaging-synthesis-and-preclinical-evaluation-of-11c-pbt2
#4
Hema S Krishnan, Vadim Bernard-Gauthier, Michael Stephen Placzek, Kenneth Dahl, Vidya Narayanaswami, Elijahu Livni, Zhen Chen, Jing Yang, Thomas Lee Collier, Chongzhao Ran, Jacob M Hooker, Steven H Liang, Neil Vasdev
Dyshomeostasis or abnormal accumulation of metal ions such as copper, zinc and iron have been linked to the pathogenesis of multiple neurodegenerative disorders including Alzheimer's disease (AD) and Huntington's disease (HD). 5,7-Dichloro-2-((dimethylamino)methyl)quinolin-8-ol, PBT2, is a second generation metal protein-attenuating compound that has recently advanced in Phase II clinical trials for the treatment of AD and HD based on promising preclinical efficacy data. Herein, we report the first radiosynthesis and preclinical positron emission tomography (PET) neuroimaging evaluation of [11C]PBT2 in rodents and nonhuman primates...
January 3, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29298367/e-cigarette-toxicity
#5
Gulay Tegin, Hema Madhuri Mekala, Simrat Kaur Sarai, Steven Lippmann
Tobacco smoking is the most preventable cause of morbidity and mortality. In just a few short years, electronic cigarettes (e-cigarettes) have become increasingly popular, especially for younger individuals. Many people believe that e-cigarettes are safe. The inhaled aerosols of e-cigarettes contain numerous potential toxicities, some of which could be dangerous for health with long-term use. The safety of prolonged aerosol exposure is not known. The use of e-cigarettes as a harm-reduction tool at stopping tobacco smoking is not uniformly successful...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29298365/associations-of-prepregnancy-morbid-obesity-and-prenatal-depression-with-gestational-weight-gain
#6
Hema Chagarlamudi, Juhee Kim, Edward Newton
OBJECTIVES: Pregnancy outcomes and infant growth and development are influenced by various prenatal and postnatal factors. Gestational weight gain (GWG) is an important indicator of pregnancy management and outcomes. Information about the interaction between prenatal obesity and depression on GWG among low-income women is limited. There also is a lack of information about morbid obesity and GWG. The purpose of this study was to examine the associations of prepregnancy weight status, including morbid obesity as a separate group, and prenatal depression with GWG using electronic medical records in an academic prenatal clinic serving a largely low-income population...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29297409/ethical-issues-related-to-consent-for-intrapartum-trials
#7
Hema Dhumale, Shivaprasad Goudar
Informed consent is the heart of ethical research. For any consent to be ethically valid, it should meet certain critical criteria- disclosure and understanding of relevant information, decision making competency of the participants, voluntariness of the decision and documentation of the agreement. Meeting all these criteria to obtain ethically valid consent from laboring women while conducting intrapartum trials is challenging because there is little time available during labor to provide study specific information necessary for the participant to understand and decide to sign the consent form...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29297352/tackling-the-hard-problems-implementation-experience-and-lessons-learned-in-newborn-health-from-the-african-health-initiative
#8
Hema Magge, Roma Chilengi, Elizabeth F Jackson, Bradley H Wagenaar, Almamy Malick Kante
BACKGROUND: The Doris Duke Charitable Foundation's African Health Initiative supported the implementation of Population Health Implementation and Training (PHIT) Partnership health system strengthening interventions in designated areas of five countries: Ghana, Mozambique, Rwanda, Tanzania, and Zambia. All PHIT programs included health system strengthening interventions with child health outcomes from the outset, but all increasingly recognized the need to increase focus to improve health and outcomes in the first month of life...
December 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29287176/removal-of-pb-ii-from-water-using-a-bio-composite-adsorbent-a-systematic-approach-of-optimizing-synthesis-and-process-parameters-by-response-surface-methodology
#9
Jayabrata Maity, Samit Kumar Ray
The synthesis parameters for preparing a novel bio-composite adsorbent by integrating a copolymer of 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM) and crosslinker N, N'-methylene bis acrylamide (MBA), polyethylene glycol (PEG) and Azadirachta Indica or Neem leaf (NL) and the process parameters for its subsequent use for adsorption of Pb(II) ion from water were optimized with central composite design (CCD) of response surface methodology (RSM). The structure of the bio-composite was characterized by FTIR, XRD, TGA, DMA, FESEM-EDX and PZC analysis...
December 26, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29286515/cortisol-level-as-risk-factor-for-malignant-hematologic-pathology-in-children-exposed-to-ionizing-radiation-after-chornobyl-accident
#10
V G Bebeshko, K M Bruslova, T I Pushkareva, N M Tsvietkova, L O Lyashenko, A S Sergeeva, V F Kuzmenko, S M Iatsemyrskiy, Yu M Samson, V G Boyarsky, I V Tryhlіb
OBJECTIVE: Determination of serum cortisol level in the initial period of acute leukemia in children, who exposed to ion izing radiation and other factors of Chornobyl accident, depending on their age and prognosis of disease. MATERIALS AND METHODS: The study involved 283 children residents of Kyiv, Zhytomyr and Chernihiv regions. There were 90 acute leukemia patients(AL) (ALL - 56, AML - 34), and 193 people of comparison group with anemia, leukemoid reactions and lymphadenopathy...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29285661/correction-to-cupriavidus-malaysiensis-sp-nov-a-novel-poly-3-hydroxybutyrate-co-4-hydroxybutyrate-accumulating-bacterium-isolated-from-the-malaysian-environment
#11
Hema Ramachandran, Nur Asilla Hani Shafie, Kumar Sudesh, Mohamad Noor Azizan, Mohamad Isa Abdul Majid, Al-Ashraf Abdullah Amirul
In the original publication of the article, it was noted that Fig. 1 present an image of Cupriavidus malaysiensis strain USMAHM13 and not of strain USMAA1020, as indicated in the figure legend. The image in the original version is thus noted to serve as a record of strain USMAHM13 and the corrected version of Fig. 1 is reprinted below.
December 28, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29282267/stepped-care-approach-for-medial-tibiofemoral-osteoarthritis-streamline-protocol-for-a-randomised-controlled-trial
#12
Sarah Rubia Robbins, Luciano Ricardo S Melo, Hema Urban, Leticia A Deveza, Rebecca Asher, Victoria L Johnson, David J Hunter
INTRODUCTION: Current guidelines recommend tailored interventions to optimise knee osteoarthritis (OA) management. However, models of care still have a 'one size fits all' approach, which is suboptimal as it ignores patient heterogeneity. This study aims to compare a stepped care strategy with standard care for overweight and obese persons with medial tibiofemoral OA. METHODS AND ANALYSIS: Participants will be randomised into two groups (85 each). The intervention will receive a diet and exercise programme for 18 weeks in the first step of the study...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29278804/adherence-of-pseudomonas-aeruginosa-onto-surfactant-laden-contact-lenses
#13
Reynalyn Mosuela, Shelan Mustafa, Simon Gould, Hany Hassanin, Raid G Alany, Amr ElShaer
There is an immense research interest to utilise contact lens (CLs) as a popular platform for ocular drug delivery. However, CLs are the major predisposing factors of bacterial keratitis which is commonly caused by adhesion of microbes such as Pseudomonas aeruginosa and Staphylococcus epidermidis. The aim of the current study is to explore the effect of surfactants; Poloxamer 188, Polysorbate 80 and Tetronic® 90R4 (at 0.25% - 3% v/v) on the characteristics of CLs and on the adhesion abilities of Pseudomonas aeruginosa to the lenses' surfaces...
December 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29276777/patient-centered-dentinal-hypersensitivity-treatment-outcomes-results-from-the-national-dental-pbrn
#14
M W Heft, M S Litaker, D T Kopycka-Kedzierawski, C Meyerowitz, S Chonowski, R L Yardic, V V Gordan, R Mungia, G H Gilbert
Dentinal hypersensitivity (DH) can have a significant impact on oral health and functioning, and it is a clinical symptom commonly managed by dentists during routine clinical practice. DH symptoms are typically elicited by otherwise innocuous, nonpainful stimuli applied to exposed dentin (e.g., tactile stimuli, warming or cooling temperatures or air puffs). Treatment approaches have sought to directly target the dentinal pulp tissues or close dentinal tubules via dental office care and treatment services (fluoride varnishes, glutaraldehydes, bonding agents, sealants, oxalates, or lasers) or home care services (toothpastes or dentifrices containing fluoride or potassium nitrate compounds)...
January 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29275438/effect-of-hydrophobic-surface-treated-fumed-silica-fillers-on-a-one-bottle-etch-and-rinse-model-dental-adhesive
#15
Jing Wang, Qingsong Yu, Zhiyuan Yang
The objective of this study was to investigate the effect of hydrophobic surface treatment to fumed silica fillers on the bonding performance of a one-bottle etch and rinse model dental adhesive. In this study, 0.5-5 wt.% of Filler 1 and Filler 2 were loaded into BisGMA/HEMA model dental adhesive. Filler 1 was not treated, while Filler 2 was surface treated with a dimethyl silicone fluid making the silica extremely hydrophobic. The prepared adhesives were characterized through measurements of viscosity, degree of conversion, and water contact angle...
December 23, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29249231/hemoglobinuric-acute-kidney-injury-in-a-patient-with-a-kinked-prosthetic-aortic-graft%C3%A2
#16
Hema V Sheelvanth, Khaleel A Sayeed, William A Whittier
Acute kidney injury (AKI) due to intravascular hemolysis has been well described in paroxysmal nocturnal hemoglobinuria (PNH) and in cardiac valvular dysfunction. However, reported cases of hemoglobinuric AKI from prosthetic aortic grafts are sparse. We present a case of microangiopathic hemolytic anemia and hemoglobinuric AKI presenting 9 days after repair of an ascending aortic dissection with a prosthetic graft. After an unremarkable recovery following the initial procedure, the patient presented on postoperative day 9 with dyspnea, fatigue, and cola-colored urine...
December 18, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29244868/cyclodextrin-containing-hydrogels-as-an-intraocular-lens-for-sustained-drug-release
#17
Xiao Li, Yang Zhao, Kaijie Wang, Lei Wang, Xiaohui Yang, Siquan Zhu
To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization...
2017: PloS One
https://www.readbyqxmd.com/read/29241441/antibody-separation-using-lectin-modified-poly-hema-edma-hydrogel-membranes
#18
Esra Feyzioğlu Demir, Cansu Ilke Kuru, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the as-synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10...
December 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29232130/atom-transfer-radical-polymerization-of-multi-shelled-cationic-corona-for-the-systemic-delivery-of-sirna
#19
Hyesung Kim, Young Ju Son, Wei Mao, Kam W Leong, Hyuk Sang Yoo
We propose an effective siRNA delivery system by preparing poly(DAMA-HEMA)-multilayered gold nanoparticles using multiple surface-initiated atom transfer radical polymerization (SI-ATRP) processes. The polymeric multilayer structure is characterized by transmission electron microscopy (TEM), matrix-associated laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and ζ-potential. The amount of siRNA electrostatically incorporated into the nanoparticle can be tuned by the number of polymeric shells, which in turn influences the cellular uptake and gene silencing effect...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29227501/chondrogenic-potential-of-macroporous-biodegradable-cryogels-based-on-synthetic-poly-%C3%AE-amino-acids
#20
T Sedlačík, O K Acar, H Studenovská, I Kotelnikov, J Kučka, Z Konečná, T Zikmund, J Kaiser, G T Kose, F Rypáček
In this study, the potential of highly porous hydrogels based on biodegradable synthetic poly(α-amino acids) to support proliferation and chondrogenesis of human dental pulp stem cells (hDPSCs) was investigated. Covalently crosslinked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydroxyethyl methacrylate (HEMA) and N-propargyl methacrylamide (PrMAAm) as minor co-monomers...
December 11, 2017: Soft Matter
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