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https://www.readbyqxmd.com/read/28650925/quantitative-analysis-of-the-inner-retinal-layer-thicknesses-in-age-related-macular-degeneration-using-corrected-optical-coherence-tomography-segmentation
#1
Ilkay Kilic Muftuoglu, Hema L Ramkumar, Dirk-Uwe Bartsch, Amit Meshi, Raouf Gaber, William R Freeman
PURPOSE: To characterize inner retinal damage in patients with dry age-related macular degeneration (AMD) using high-resolution spectral domain optical coherence tomography images. METHODS: Sixty eyes of 60 patients with AMD were categorized using the Age-Related Eye Disease Study (AREDS) severity scale. Spectral domain optical coherence tomography images of these patients were quantified by manually correcting the segmentation of each retinal layer, including the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer to ensure accurate delineation of layers...
June 23, 2017: Retina
https://www.readbyqxmd.com/read/28638495/an-atypical-presentation-of-congenital-pulmonary-airway-malformation-cpam-a-rare-case-with-antenatal-ultrasound-findings-and-review-of-literature
#2
Munnangi Satya Gautam, Srinivas M Naren Satya, Ivvala Sai Prathyusha, K Hema Chandra Reddy, Kamala Retnam Mayilvaganan, Deepthi Raidu
BACKGROUND: Congenital pulmonary airway malformation (CPAM) is a relatively rare congenital anomaly with a wide spectrum of ultrasound features depending on the specific variety of CPAM. Antenatal ultrasound is a valuable, safe, nonionizing, cost-effective, widely available and easily reproducible imaging tool and is indispensable in the diagnosis of CPAM. In this paper, we aimed to report an atypical imaging presentation of CPAM type II in the second trimester, extensively involving all lobes of the left lung...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28629032/effects-of-silane-modified-fillers-on-properties-of-dental-composite-resin
#3
Aysu Aydınoğlu, Afife Binnaz Hazar Yoruç
The effect of silanization on the mechanical, chemical, and physical properties of dental composites was investigated. Silica fillers were obtained from colloidal silica solution, Ludox® HS-40 and they were silanized by using 3-methacryloxypropyl trimethoxysilane (MPTMS) in an acidic media. Mineralogical and chemical structures of unsilanized and silanized fillers were determined by using XRD and FT-IR analyses. The modification of unsilanized/silanized fillers were investigated by performing XPS and TGA analyses...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28619124/multiplex-tests-to-identify-gastrointestinal-bacteria-viruses-and-parasites-in-people-with-suspected-infectious-gastroenteritis-a-systematic-review-and-economic-analysis
#4
Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Pam Royle, Noel McCarthy, Sian Taylor-Phillips, Rohini Manuel, James Mason
BACKGROUND: Gastroenteritis is a common, transient disorder usually caused by infection and characterised by the acute onset of diarrhoea. Multiplex gastrointestinal pathogen panel (GPP) tests simultaneously identify common bacterial, viral and parasitic pathogens using molecular testing. By providing test results more rapidly than conventional testing methods, GPP tests might positively influence the treatment and management of patients presenting in hospital or in the community. OBJECTIVE: To systematically review the evidence for GPP tests [xTAG(®) (Luminex, Toronto, ON, Canada), FilmArray (BioFire Diagnostics, Salt Lake City, UT, USA) and Faecal Pathogens B (AusDiagnostics, Beaconsfield, NSW, Australia)] and to develop a de novo economic model to compare the cost-effectiveness of GPP tests with conventional testing in England and Wales...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28618214/how-to-stop-smoking
#5
Priyanga Jayakumar, Hema Madhuri Mekala, Rajashekar Reddy Yeruva, Steven Lippmann
Despite the known dangers of cigarette smoking, many smokers do not use effective means for cessation. Smoking-cessation guidelines recommend a variety of psychological and medicinal options that include nicotine-replacement products, pharmaceuticals, and electronic cigarettes. This article describes these smoking-cessation options and provides guidance for physicians.
June 8, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28617337/tunable-temperature-response-of-a-thermochromic-photonic-gel-sensor-containing-n-isopropylacrylamide-and-4-acryloyilmorpholine
#6
Hwanam Kye, Young Gook Koh, Youkyung Kim, Sung Gu Han, Hyunjung Lee, Wonmok Lee
In this study, thermochromic photonic gels were fabricated using 2-hydroxyethyl methacrylate (HEMA) as a hydrogel building block, and 4-Acryloyl morpholine (ACMO) and N-isopropylacrylamide (NIPAAM) as thermoresponsive monomers with different critical solution temperature behaviors. Rapid photopolymerization of opal-templated monomer mixtures of varying ACMO contents formed five individual thermochromic inverse opal photonic gels integrated on a single substrate. With temperature variation from 10 °C to 80 °C, the changes in reflective colors and reflectance spectra of the respective thermochromic gels were noted, and λpeak changes were plotted...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28607915/engineering-cord-blood-to-improve-engraftment-after-cord-blood-transplant
#7
REVIEW
Rohtesh S Mehta, Hema Dave, Catherine M Bollard, Elizabeth J Shpall
Umbilical cord blood transplant (CBT) has traditionally been associated with slower engraftment of neutrophils, delayed immune reconstitution and consequently higher risk of infections as compared with peripheral blood progenitor cell (PBPC) or bone marrow (BM) transplants. This is primarily due to low numbers of total nucleated cells (TNCs) and the naive nature of CB immune cells. The use of double unit CB transplant (DCBT) increases the total cell dose in the graft, but it still does not produce as rapid engraftment as seen with PBPC or even BM transplants...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28605747/histopathological-and-immunohistochemical-findings-in-congenital-pouch-colon-a-prospective-study
#8
Hema Udawat, Vandana Nunia, Praveen Mathur, Harsh Prasad Udawat, Kusum Lata Gaur, Amulya K Saxena, M Krishna Mohan
BACKGROUND: There is a paucity of literature on the histopathological aspects of congenital pouch colon (CPC) and immunohistochemical (IHC) assessment has not been reported. So we planned to study the histopathological and IHC findings within the spectrum of CPC and compare the findings with the normal colon. METHODS: This is a descriptive prospective study on CPC patients. There were 49 cases of CPC (42 males and 7 females) and 13 controls. Histological examination was done using hematoxylin and eosin and Masson trichrome stain...
June 13, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28604541/high-dose-high-frequency-aflibercept-for-recalcitrant-neovascular-age-related-macular-degeneration
#9
Qi Sheng You, Raouf Gaber, Amit Meshi, Hema L Ramkumar, Mostafa Alam, Ilkay Kilic Muftuoglu, William R Freeman
PURPOSE: To determine the efficacy of monthly (0.1 mL/4 mg) aflibercept for refractory neovascular age-related macular degeneration (wet age-related macular degeneration). METHODS: This was a retrospective interventional case series in which patients with wet age-related macular degeneration were treated with stepwise dose escalation. Nonvitrectomized patients resistant to monthly (Q4W) ranibizumab/bevacizumab were switched to 2 mg aflibercept every 8 weeks. With resistance, they were escalated to Q4W 2 mg aflibercept, then Q4W 4 mg (high dose high frequency, 4Q4W) aflibercept...
June 9, 2017: Retina
https://www.readbyqxmd.com/read/28602330/mean-shape-of-the-human-limbus
#10
Alejandra Consejo, Clara Llorens-Quintana, Hema Radhakrishnan, D Robert Iskander
PURPOSE: To characterize the mean topographic shape of the limbus of a normal human eye and determine whether it depends on age or refractive power. SETTING: University of Manchester, Manchester, United Kingdom. DESIGN: Prospective case series. METHODS: Participants with no previous ocular surgeries were included in this study. The left eye was measured with a corneoscleral topographer (Eye Surface Profiler). From the raw anterior eye height data, the topographic limbus was demarcated and fitted in 3 dimensions to a circle, an ellipse, and a Fourier series...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28602017/design-and-evaluation-of-artificial-cornea-with-core-skirt-design-using-polyhydroxyethyl-methacrylate-and-graphite
#11
Mukty Sinha, Tanvi Gupte
PURPOSE: Artificial cornea is the effective treatment option for corneal blindness. One of the challenges with the artificial cornea is limited, or no tissue integration necessitates reimplantation due to necrosis or corneal melting. We propose here a new formulation approach for core-skirt incorporating graphite in the outer skirt region to improve cell adhesion. METHODS: Hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate were procured from Sigma-Aldrich...
June 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28591799/incentivizing-universal-safe-delivery-in-nepal-10%C3%A2-years-of-experience
#12
Tim Ensor, Hema Bhatt, Suresh Tiwari
Payments to users and providers of health services are an important ingredient in attempts to promote universal health coverage in low resource settings. The maternal health programme in Nepal explicitly recognizes that ensuring universal access to safe delivery care requires policies that both ensure effective services and overcome demand-side barriers. The programme has used three innovative financing initiatives to stimulate an increase in the use of facility-based delivery: the maternity incentive scheme (2005) reimbursing women for accessing a facility, activity payments in poor districts (2006) and universal free-delivery (2009)...
June 7, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28583826/risk-stratification-for-covert-invasive-cancer-among-patients-referred-for-colonic-endoscopic-mucosal-resection-a-large-multi-center-cohort
#13
Nicholas G Burgess, Luke F Hourigan, Simon A Zanati, Gregor J Brown, Rajvinder Singh, Stephen J Williams, Spiro C Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Hema Mahajan, Duncan McLeod, Michael J Bourke
BACKGROUND & AIMS: Among patients with large colorectal sessile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal invasive cancer (SMIC). Lesions with overt endoscopic evidence of SMIC are referred for surgery, although those without these features might still contain SMIC that is not visible on endoscopic inspection (covert SMIC). Lesions with a high covert SMIC risk might be better suited for endoscopic submucosal dissection (ESD) than for endoscopic mucosal resection (EMR)...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28571520/profiles-of-elderly-people-infected-with-hiv-and-response-to-antiretroviral-treatment-in-burkina-faso-a-retrospective-cohort-study
#14
Ismaël Diallo, Nicolas Meda, Smaïla Ouédraogo, Armel Poda, Arsène Hema, Yempabou Sagna, Lynda M Sawadogo, Youssouf J Drabo, Dieu-Donné Ouedraogo
BACKGROUND: In sub-Saharan Africa, few studies exist on elderly HIV-positive populations. Therefore, we aimed to examine the profiles of elderly people living with HIV (PLHIV) in Burkina Faso and their response to antiretroviral therapy (ART). METHODS: We reviewed the monitoring and treatment of PLHIV over the age of 50 years and then compared with the monitoring and treatment of PLHIV under 50 years. RESULTS: A total of 3367 patients were included...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28571152/oncogenic-osteomalacia-an-approach-to-diagnosis-with-a-case-report
#15
Biswajit Dey, Debasis Gochhait, Hema Subramanian, Madhusudhanan Ponnusamy
Oncogenic osteomalacia, also known as tumour induced osteomalacia, is a rare paraneoplastic syndrome caused by mesenchymal tumours secreting Fibroblast Growth Factor-23 (FGF-23). The characteristic biochemical findings include hypophosphatemia and low 1,25-dihydroxy vitamin D. The differential diagnosis for hypophosphatemia are varied. We present a case of oncogenic osteomalacia in a 29-year-old female, who presented with complaints of generalized diffuse bone pain and walking difficulty for six months duration...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28551079/adhesion-attenuates-respiratory-burst-induced-by-different-modes-of-triggering-in-resting-or-lps-primed-neutrophils
#16
Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura
The effects of adherence on neutrophil superoxide anion (O2(-)) generation triggered by surface, soluble ligand, or adherence were studied. Resting-neutrophils adhered to the uncoated tubes resulting in O2(-) generation, but not on plasma-, fibrinogen-, vitronectin-, fibronectin-, laminin-, collagen-, or poly HEMA-coated surfaces. Enhanced N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated O2(-) generation by LPS-primed-neutrophils was induced by the incubation on plasma, fibrinogen, vitronectin, fibronectin, or laminin in the absence of Mg(2+)...
August 2017: Immunobiology
https://www.readbyqxmd.com/read/28545818/boron-nitride-nanotubes-as-novel-fillers-for-improving-the-properties-of-dental-adhesives
#17
Felipe Weidenbach Degrazia, Vicente Castelo Branco Leitune, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
OBJECTIVE: This study aimed to evaluate the physical-chemical properties of experimental dental adhesives containing boron nitride nanotubes (BNNTs) as inorganic fillers. METHODS: An experimental adhesive resin was prepared using HEMA-BisGMA, 66/33wt% (control). Inorganic BNNT fillers were first analyzed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and then incorporated into the adhesive at different concentration (0.05, 0...
May 22, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28545657/durability-of-a-low-shrinkage-tegdma-hema-free-resin-composite-system-in-class-ii-restorations-a-6-year-follow-up
#18
Jan W V van Dijken, Ulla Pallesen
OBJECTIVE: The objective of this randomized controlled prospective trial was to evaluate the durability of a low shrinkage and TEGDMA/HEMA-free resin composite system in posterior restorations in a 6-year follow up. METHODS: 139 Class II restorations were placed in 67 patients with a mean age of 53 years (range 29-82). Each participant received at random two, as similar as possible, Class II restorations. In the first cavity of each pair the TEGDMA/HEMA-free resin composite system was placed with its 3-step etch-and-rinse adhesive (cmf-els)...
May 22, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28538217/the-significance-of-glandular-cells-on-conventional-cervicovaginal-smears-experience-from-a-tertiary-care-hospital-in-coastal-india
#19
Pooja K Suresh, Hema Kini, Jessica Minal, Neha Dhavalpure, Sridevi H Basavaiah, Deepa S Adiga, Laveena Maben
INTRODUCTION: Glandular lesions of the female genital tract (FGT) are quite uncommon compared to squamous lesions. Their cytological diagnosis is difficult because of their architectural and cytological complexity, as well as the lack of experience of many cytopathologists in this field. The aim of this study was to determine the significance of Papanicolaou (Pap) smears in the diagnosis of glandular FGT lesions. METHODOLOGY: All Pap smears reported during the period of January 2012 to December 2013 were retrieved...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28536938/enhancement-of-5-aminolevulinic-acid-production-by-metabolic-engineering-of-the-glycine-biosynthesis-pathway-in-corynebacterium-glutamicum
#20
Yalan Zou, Tao Chen, Lili Feng, Shuanghong Zhang, Dongxu Xing, Zhiwen Wang
OBJECTIVE: To construct a strain of Corynebacterium glutamicum capable of efficiently producing 5-aminolevulinic acid (5-ALA) via the C4 pathway by modification of serine and glycine pathway using glucose as sole carbon source. RESULTS: The recombinant C. glutamicum strain AP2 harboring a codon-optimized hemA gene from Rhodobacter sphaeroides was used as host strain for 5-ALA production. A plasmid harboring the serine operon, which contained serB, serC and the site-specific mutant serA (Δ197) , was constructed and introduced into C...
May 23, 2017: Biotechnology Letters
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