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Raquel Palao-Suay, María Rosa Aguilar, Francisco J Parra-Ruiz, Samarendra Maji, Richard Hoogenboom, Nathan A Rohner, Susan N Thomas, Julio San Román
Well-structured amphiphilic copolymers are necessary to obtain self-assembled nanoparticles (NPs) based on synthetic polymers. Highly homogeneous and monodispersed macromolecules obtained by controlled polymerization have successfully been used for this purpose. However, disaggregation of the organized macromolecules is desired when a bioactive element, such as α-tocopheryl succinate, is introduced in self-assembled NPs and this element must be exposed or released to exert its action. The aim of this work is to demonstrate that the bioactivity of synthetic NPs based on defined reversible addition-fragmentation chain transfer polymerization copolymers can be enhanced by the introduction of hydrophilic comonomers in the hydrophobic segment...
October 14, 2016: Macromolecular Bioscience
Erich Hellemann, Rubens R Teles, Fernando Hallwass, W Barros, Armando Navarro-Vázquez, Roberto R Gil
Anisotropic NMR parameters, such as residual dipolar couplings (RDCs), residual chemical shift anisotropies (RCSAs) and residual quadrupolar couplings (RQCs or ΔνQ ), appear in solution-state NMR when the molecules under study are subjected to a degree of order. The tunable alignment by reversible compression/relaxation of gels (PMMA and p-HEMA) is an easy, user-friendly, and very affordable method to measure them. When using this method, a fraction of isotropic NMR signals is observed in the NMR spectra, even at a maximum degree of compression...
October 14, 2016: Chemistry: a European Journal
Junsheng Li, Barbara Kwiatkowska, Hao Lu, Maren Voglstätter, Erika Ueda, Michael Grunze, Jonathan Sleeman, Pavel A Levkin, Irina Nazarenko
Malignant transformation is associated with enhancement of cell plasticity, which allows cancer cells to survive under different conditions by adapting to their microenvironment during growth and metastatic spread. Much effort has been devoted to understanding the molecular mechanisms of these processes. Although the importance of the extracellular matrix and of surface properties in these mechanisms is evident, the direct impact of distinct physical and chemical surfaces characteristics on cell fate remains unclear...
October 12, 2016: ACS Applied Materials & Interfaces
P Sadhasivam, C Ganesan, Vetrivel, Hema
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Tadinada Lakshmi Hema, M Madhusudhana Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Arvind Hariharan, N R Diwakar, K Jayanthi, H M Hema, S Deepukrishna, Snehal R Ghaste
CONTEXT: This study compared digital two-dimensional (2D) lateral cephalograms and cone-beam computed tomography (CBCT) total and half-skull images for the reliability of cephalometric measurements. AIMS: (1) To compare the accuracy of cephalometric measurements and reproducibility between the digital and CBCT cephalograms in the Indian population. (2) To compare interobserver variability in landmark identification through their cephalometric measurements by comparing different imaging modalities (CBCT total skull, CBCT half-skull, and conventional lateral cephalogram)...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Thomas G Poder, Denise Pruneau, Josée Dorval, Louis Thibault, Jean-François Fisette, Suzanne K Bédard, Annie Jacques, Patrice Beauregard
BACKGROUND: Blood warmers were developed to reduce the risk of hypothermia associated with the infusion of cold blood products. During massive transfusion, these devices are used with compression sleeve, which induce a major stress to red blood cells. In this setting, the combination of blood warmer and compression sleeve could generate hemolysis and harm the patient. We conducted this study to compare the impact of different pressure rates on the hemolysis of packed red blood cells and on the outlet temperature when a blood warmer set at 41...
2016: PloS One
Amandine Cournil, Arsène Hema, Sabrina Eymard-Duvernay, Laura Ciaffi, Stéphanie Badiou, Firmin N Kabore, Assane Diouf, Liliane Ayangma, Vincent Le Moing, Jacques Reynes, Sinata Koulla-Shiro, Eric Delaporte
BACKGROUND: To investigate change in renal function in African patients initiating second line ART including ritonavir-boosted protease inhibitor (PI/r) with or without tenofovir disoproxil fumarate (TDF). METHODS: HIV-1 positive adults, failing standard first line ART were randomized to either TDF/FTC+LPV/r; ABC+ddI+LPV/r or TDF/FTC+DRV/r and followed until 18 months. Patients with an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1,73m(2) at baseline were included in this analysis...
October 5, 2016: Antiviral Therapy
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N-bis(acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content...
January 2, 2017: Carbohydrate Polymers
Jaffer A Ajani, Thomas A D'Amico, Khaldoun Almhanna, David J Bentrem, Joseph Chao, Prajnan Das, Crystal S Denlinger, Paul Fanta, Farhood Farjah, Charles S Fuchs, Hans Gerdes, Michael Gibson, Robert E Glasgow, James A Hayman, Steven Hochwald, Wayne L Hofstetter, David H Ilson, Dawn Jaroszewski, Kimberly L Johung, Rajesh N Keswani, Lawrence R Kleinberg, W Michael Korn, Stephen Leong, Catherine Linn, A Craig Lockhart, Quan P Ly, Mary F Mulcahy, Mark B Orringer, Kyle A Perry, George A Poultsides, Walter J Scott, Vivian E Strong, Mary Kay Washington, Benny Weksler, Christopher G Willett, Cameron D Wright, Debra Zelman, Nicole McMillian, Hema Sundar
Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of death from cancer in the world. Several advances have been made in the staging procedures, imaging techniques, and treatment approaches. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Gastric Cancer provide an evidence- and consensus-based treatment approach for the management of patients with gastric cancer. This manuscript discusses the recommendations outlined in the NCCN Guidelines for staging, assessment of HER2 overexpression, systemic therapy for locally advanced or metastatic disease, and best supportive care for the prevention and management of symptoms due to advanced disease...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Kadir Erol
The separation and purification methods are extremely important for the hemoglobin (Hb) which is a crucial biomolecule. The adsorption technique is popular among these methods and the cryogels have been used quite much due to their macropores and interconnected flow channels. In this study, the Hb adsorption onto the Cu(II) immobilized poly(2-hydroxyethyl methacrylate-glycidyl methacrylate), poly(HEMA-GMA)-Cu(II), cryogels was investigated under different conditions (pH, interaction time, initial Hb concentration, temperature and ionic strength) to optimize adsorption conditions...
August 10, 2016: Artificial Cells, Nanomedicine, and Biotechnology
Jerusha A Hema, Rajkumari Malaka, Narayanan P Muthukumarasamy, Akilandeswari Sambandam, Subakanmani Subramanian, Murugan Sevanan
The biosynthesis of silver nanoparticles (AgNPs) has been proved to be a cost effective and environmental friendly approach toward chemical and physical methods. In the present study, biosynthesis of AgNPs was carried out using aqueous extract of Zea mays (Zm) husk. The initial colour change from golden yellow to orange was observed between 410 and 450 nm which confirmed the synthesis of AgNPs. Also, dynamic light scattering-particle size analysis confirmed the average size to be 113 nm and zeta potential value of -28 kV...
October 2016: IET Nanobiotechnology
C Kerezoudi, C Gogos, V Samanidou, D Tziafas, G Palaghias
OBJECTIVE: To evaluate the elution of HEMA, BPA, UDMA and BisGMA from a conventional resin cement (Multilink Automix(®), Ivoclar Vivadent) through human dentin, under constant positive pulpal pressure. METHODS: Ten human dentin disks (n=10) were adjusted in a new testing device and transparent glass slabs were luted with Multilink Automix(®) resin cement, following manufacturer's instructions, under a steady pressure of 25N. The device was filled with Ringer's solution...
September 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Helmut Schweikl, Matthias Widbiller, Stephanie Krifka, Johannes Klement, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Wolfgang Buchalla
OBJECTIVE: Lipopolysaccharide (LPS) from cariogenic microorganisms and resin monomers like HEMA (2-hydroxyethyl methacrylate) included in dentin adhesive are present in a clinical situation in deep dentinal cavity preparations. Here, cell survival, expression of proteins related to redox homeostasis, and viability of mouse macrophages exposed to LPS and HEMA were analyzed with respect to the influence of oxidative stress. METHODS: Cell survival of RAW264.7 mouse macrophages was determined using a crystal violet assay, protein expression was detected by Western blotting, and HEMA- or LPS-induced apoptosis (cell viability) was analyzed by flow cytometry...
September 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Tatiana Foscaldo, Glauco Botelho Dos Santos, Luciana Meirelles Miragaya, Marcelle Garcia, Viviane Hass, Eduardo Moreira da Silva
PURPOSE: To evaluate the effect of dentin treatment using HEMA phosphate (HEMA-P) on the microtensile bond strength (μTBS) and nanoleakage of an etch-and-rinse adhesive system. MATERIALS AND METHODS: The occlusal surfaces of human molars were wet ground until superficial dentin was exposed. The specimens were then assigned to two groups according to dentin treatment: PA: 37% H₃PO₄ for 15 s; or HP: HEMA-P for 15 s. Adper Single Bond 2 was applied to the treated dentin surfaces and resin composite buildups were incrementally constructed over them...
September 23, 2016: Journal of Adhesive Dentistry
Valeria B Gotti, Américo B Correr, Steven H Lewis, Victor P Feitosa, Lourenço Correr-Sobrinho, Jeffrey W Stansbury
OBJECTIVE: To assess the influence of hydrophilicity of reactive nanogels on the mechanical performance of dental adhesives and microtensile bond strength (μTBS) to dentin after 24h or 3 months of aging. METHODS: A series of three nanogels were synthesized: NG1-IBMA/UDMA; NG2-HEMA/BisGMA; NG3-HEMA/TE-EGDMA. The nanogels were dispersed in solvent, HEMA or BisGMA/HEMA. The degree of conversion (DC) of the materials was measured and the flexural modulus of these polymers was evaluated in dry or wet conditions...
September 21, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Xiaoli Yu, Haiying Jin, Xuelian Cheng, Qian Wang, Qingsheng Qi
5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthetic pathway, attracts close attention among researchers because of its potential applications to cancer treatment and agriculture. Overexpression of heterologous hemA and hemL, which encode glutamyl-tRNA reductase and glutamate-1-semialdehyde aminotransferase, respectively, in Corynebacterium glutamicum produces ALA, although whether ALA accumulation causes unintended effects on the host is unknown. Here we used an integrated systems approach to compare global transcriptional changes induced by the expression of hemA and hemL...
November 2016: Microbiological Research
T S Anirudhan, Anoop S Nair, J Parvathy
An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-g-HEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Successful reloading of TML onto the lens was monitored using a simple and novel UV-Visible spectrophotometric method which showed an excellent reloading capacity of 6...
September 20, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Anju Verma, Hema Joshi, Vineeta Singh, Anup Anvikar, Neena Valecha
BACKGROUND: Plasmodium vivax is the most widely distributed human malaria parasite and accounts for approximately the same number of malaria cases as Plasmodium falciparum in India. Compared with P. falciparum, P. vivax is difficult to eradicate because of its tendency to cause relapses, which impacts treatment and control strategies. The genetic diversity of these parasites, particularly of the merozoite surface protein-3 alpha (msp-3α) gene, can be used to help develop a potential vaccine...
2016: Malaria Journal
Diana Braunholz, Mohammad Saki, Franziska Niehr, Merve Öztürk, Berta Borràs Puértolas, Robert Konschak, Volker Budach, Ingeborg Tinhofer
In solid tumours millions of cells are shed into the blood circulation each day. Only a subset of these circulating tumour cells (CTCs) survive, many of them presumable because of their potential to form multi-cellular clusters also named spheroids. Tumour cells within these spheroids are protected from anoikis, which allows them to metastasize to distant organs or re-seed at the primary site. We used spheroid cultures of head and neck squamous cell carcinoma (HNSCC) cell lines as a model for such CTC clusters for determining the role of the epidermal growth factor receptor (EGFR) in cluster formation ability and cell survival after detachment from the extra-cellular matrix...
2016: PloS One
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