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Benzo(a)pyrene

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https://www.readbyqxmd.com/read/28822029/gene-structure-and-comparative-and-phylogenetic-analyses-of-catla-catla-cyp1a-full-length-cdna-and-its-responsiveness-to-benzo-a-pyrene-and-copper-sulphate-at-early-developmental-stages
#1
Kavita Kumari, Gireesh-Babu Pathakota, Shivendra Kumar, Gopal Krishna
In the present study, full-length CYP1A cDNA from Catla catla (Catla) has been identified, and its real-time quantitative reverse transcription PCR (qRT-PCR) expression has been evaluated in different tissues, developmental stages (0, 3, 6, 12 and 24 h and 5, 7 and 9 days post-fertilization) and copper sulphate and benzo(a)pyrene (BaP)-treated 5-day post-fertilization (dpf) larvae (6 to 6.5 mm). Various structural, comparative and phylogenetic analyses of the deduced amino acid sequence revealed that the identified gene of Catla belongs to the CYP1A1 subfamily...
August 19, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28813539/vectorization-by-nanoparticles-decreases-the-overall-toxicity-of-airborne-pollutants
#2
Rodolphe Carpentier, Anne Platel, Helena Maiz-Gregores, Fabrice Nesslany, Didier Betbeder
Atmospheric pollution is mainly composed of volatile pollutants and particulate matter that strongly interact. However, their specific roles in the induction of cellular toxicity, in particular the impact of the vectorization of atmospheric pollutants by ultrafine particles, remains to be fully elucidated. For this purpose, non-toxic poly-lactic co-glycolic acid (PLGA) nanoparticles were synthesized and three pollutants (benzo(a)pyrene, naphthalene and di-ethyl-hexyl-phthalate) were adsorbed on the surface of the nanoparticles in order to evaluate the toxicity (cytotoxicity, genotoxicity and ROS induction) of these complexes to a human airway epithelial cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28812058/environmental-pollutants-and-neurodevelopment-review-of-benefits-from-closure-of-a-coal-burning-power-plant-in-tongliang-china
#3
Vrinda Kalia, Frederica Perera, Deliang Tang
Background. Understanding preventable causes of neurodevelopmental disorders is a public health priority. Polycyclic aromatic hydrocarbons (PAH) from combustion of fossil fuel, lead, and mercury are among known neurodevelopmental toxicants. Method. For the first time, we comprehensively review the findings from a study by the Columbia Center for Children's Environmental Health and Chinese partners that followed 2 groups of mother-child pairs, one from 2002 and another from 2005, in Tongliang County, China. Pregnant mothers in the 2 cohorts experienced different exposure to PAH because a local coal-burning power plant was shut down in 2004...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28808779/optimisation-of-extraction-methods-and-quantification-of-benzo-a-pyrene-and-benz-a-anthracene-in-yerba-mat%C3%A3-tea-by-isotope-dilution-mass-spectrometry
#4
Ee Mei Gui, Ting Lu, Tang Lin Teo, Pui Sze Cheow, Tong Kooi Lee
A gas chromatography-isotope dilution mass spectrometry (GC-IDMS) technique was developed for the quantification of two heavy polyaromatic hydrocarbons (PAHs), benz[a]anthracene and benzo[a]pyrene, in yerba maté tea (maté). The optimisation of two extraction methods, namely liquid-liquid extraction and accelerated solvent extraction, was carried out. Both optimised methods were validated using a certified reference material of fine dust and the results were within the expanded uncertainties at 95% confidence level...
August 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28807506/altered-vulnerability-to-asthma-at-various-levels-of-ambient-benzo-a-pyrene-by-ctla4-stat4-and-cyp2e1-polymorphisms
#5
Hyunok Choi, Nana Tabashidze, Pavel Rossner, Miroslav Dostal, Anna Pastorkova, Sek Won Kong, Hans Gmuender, Radim J Sram
BACKGROUND: Within fossil- and solid-fuel dependent geographic locations, mechanisms of air pollution-induced asthma remains unknown. In particular, sources of greater genetic susceptibility to airborne carcinogen, namely, benzo[a]pyrene (B[a]P) has never been investigated beyond that of a few well known genes. OBJECTIVES: To deepen our understanding on how the genotypic variations within the candidate genes contribute to the variability in the children's susceptibility to ambient B[a]P on doctor-diagnosed asthma...
August 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28802573/cytotoxicity-and-cyp1a-inhibition-in-rainbow-trout-liver-rtl-w1-cell-lines-exposed-to-dispersant-corexit-9500-and-its-major-surfactant-components
#6
Subham Dasgupta, Anne E McElroy
As part of a large study examining the toxicity of the Corexit® family of oil spill dispersants on aquatic vertebrates, we examined effects on the liver in an in vitro study using the rainbow trout liver cell line (RTL-W1). We exposed RTL-W1 cells to the dispersant Corexit 9500 and its major surfactant components and measured their cytotoxic effects as well as modulation of activity of CYP1A, one of the major enzymes responsible for organic contaminant metabolism. The anionic surfactant DOSS was found to be the most cytotoxic with a 24h EC50 of 10mg/L, as compared to 45 to 91mg/L for the non-ionic surfactants, Tween 80 and 85 and Span 80...
August 9, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28800488/benzo-a-pyrene-induced-a-mitochondria-independent-apoptosis-of-liver-in-juvenile-chinese-rare-minnows-gobiocypris-rarus
#7
Jinmiao Zha, Xiangsheng Hong, Haiou Rao, Lilai Yuan, Zijian Wang, Satyanarayanan Senthil Kumaran
To examine the effects of BaP on tissue apoptosis, laboratory studies were conducted using juvenile Chinese rare minnows (Gobiocypris rarus) exposed to 1, 5, 20, and 80 μg/L of BaP for 28 days. The post-treatment pathological findings in the liver were associated with hepatocyte swelling, karyopyknosis, and karyorrhexis. Moreover, an increase in the goblet cells in the intestine, epithelial hyperplasia of the gills and fusion of gill lamellae were observed. Significant increases in hepatocyte apoptosis using the TUNEL stain were observed in the liver tissue but not in the intestine and gills...
August 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28798528/dosimetry-for-lung-tumorigenesis-induced-by-urethane-4-n-methyl-n-nitrosamino-1-3-pyridyl-1-butanone-nnk-and-benzo-a-pyrene-b-a-p-in-a-jjmsslc-mice
#8
Saeko Onami, Chigusa Okubo, Asuka Iwanaga, Hiroaki Suzuki, Hajime Iida, Yurie Motohashi, Yuki Tomonari, Seiji Otake, Hiroyuki Tsuji, Hiroyuki Yoshimura
Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28795330/acetylcholinesterase-and-heat-shock-protein-70-response-in-larval-brain-tissue-of-lymantria-dispar-l-lepidoptera-limantriidae-upon-chronic-exposure-to-benzo-a-pyrene
#9
Larisa Ilijin, Marija Mrdaković, Milena Vlahović, Dragana Matić, Anja Gavrilović, Aleksandra Mrkonja, Vesna Perić-Mataruga
The effects of different concentrations of benzo(a)pyrene (BaP) (2, 10, 20, 100, 200, and 2000 ng/g dry food weight) on the activity of acetylcholinesterase (AChE) and concentration of heat-shock protein 70 (hsp70) in fifth instar Lymantria dispar brain tissue were investigated. Inhibition of AChE is a general effect biomarker at the individual level. We observed the most efficient inhibition of this enzyme at medium and high BaP concentrations (20, 100, 200, and 2000 ng/g dry food weight). Western blot analysis revealed the presence of two hsp 70 isoforms, with changed amounts depending on the BaP concentration...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28795279/human-health-risk-assessment-and-pahs-in-a-stretch-of-river-ganges-near-kanpur
#10
Pooja Srivastava, T R Sreekrishnan, A K Nema
The presence of 13 polycyclic aromatic hydrocarbons (PAHs) was measured in a small stretch of river Ganges in Kanpur, using high-performance liquid chromatography equipped with photodiode array detector (HPLC/PDA). Non-carcinogenic risk on human health was calculated in the form of hazardous index. Carcinogenic risk was calculated as chronic daily intake and incremental lifetime cancer risk (ILCR) with the help of monitored PAHs in river water. Due to non-availability of reference dose (RfD) values for all the 13 PAHs, the combined hazardous index for three PAHs was calculated...
August 10, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28791412/benzo-a-pyrene-enhances-the-emt-associated-migration-of-lung-adenocarcinoma-a549-cells-by-upregulating-twist1
#11
Xi Chen, Hongbing Peng, Jian Xiao, Anqi Guan, Bin Xie, Bixiu He, Qiong Chen
Benzo(a)pyrene (BaP), an important toxic component of cigarette smoke, can cause lung cancer and lead to the progression of lung cancer. In the present study, we investigated the effect of BaP on the migration of lung adenocarcinoma A549 cells. BaP (1 µM) promoted the migration of A549 cells in a time-dependent manner and upregulated the expression of the Twist family BHLH transcription factor 1 (Twist1). BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin...
August 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28782227/short-androgen-receptor-poly-glutamine-promoted-endometrial-cancer-is-associated-with-benzo-a-pyrene-mediated-aryl-hydrocarbon-receptor-activation
#12
Lumin Chen, Bo-Ying Bao, Wei-Chun Chang, Jason Yen-Ping Ho, Bi-Hua Cheng, Chung-Lin Wang, Qifeng Tang, Wei-Chung Cheng, Hui-Wen Chang, Yao-Ching Hung, Wen-Lung Ma
The androgen receptor (AR) poly-glutamine polymorphism (AR-Q) was reported to play role in endometrial cancer (EMCA) development, yet controversial. Environmental factors interact with genetic variation have been reported in EMCA. Aerosol toxins, polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP), are EMCA facilitators. This report examined the interplay between AR-Qs and BaP in EMCA. During analysing patient AR-Q polymorphism and Aryl hydrocarbon Receptor (AhR) expressions, we found overall survival (OS) benefit is ascending with AR-Q lengths (5-year OS of 61...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28758069/investigating-the-application-of-a-nitroreductase-expressing-transgenic-zebrafish-line-for-high-throughput-toxicity-testing
#13
Anna C Chlebowski, Jane K La Du, Lisa Truong, Staci L Massey Simonich, Robert L Tanguay
Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded. Transgenic zebrafish models have been developed for tissue-specific cell ablation, which use nitroreductase to ablate specific tissues or cell types following exposure to the non-toxic pro-drug metronidazole (MTZ). When metabolized by nitroreductase, MTZ produces a potent cytotoxin, which specifically ablates the tissue in which metabolism occurs...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28741116/application-of-multivariate-curve-resolution-alternate-least-square-technique-on-extracting-pure-spectral-components-from-multiple-emitting-systems-a-case-study
#14
Madhumita Tarai, Ashok Kumar Mishra
Multiple emitting components in a fluorophoric system often produce complicated emission spectra. Extracting the individual spectral information from the composite spectra is important in order to comprehend the photophysical processes occurring in the multifluorophoric systems. Although the combination of Principal Component Analysis and Multivariate Curve Resolution-Alternate Least Square (PCA/MCR-ALS) technique is a well-known approach for curve deconvolution, its applicability in the spectral deconvolution of vibronically and electronically mixed up emitting systems as well as systems merged up with multiple electronic bands without a priori knowledge of the individual emitting species, is not properly studied...
July 24, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28738571/determination-of-polycyclic-aromatic-hydrocarbons-in-infant-formula-using-solid-state-urea-clathrate-formation-with-gas-chromatography-tandem-mass-spectrometry
#15
Zoltán Nyiri, Márton Novák, Zsolt Bodai, Noémi Petrovics, Zsuzsanna Eke
An analytical method has been developed for the quantitative determination of the 16 EU priority polycyclic aromatic hydrocarbons (PAHs) in infant formula. Prior to analysis infant formula is subjected to sample preparation including the extraction of PAHs from the sample, transesterification of the triglyceride content of the extract to fatty acid methyl esters (FAMEs), and solid state urea clathrate formation to remove the FAMEs. Measurements were carried out with gas chromatography - tandem mass spectrometry...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28736785/rapid-and-ultrasensitive-detection-of-endocrine-disrupting-chemicals-using-a-nanosensor-enabled-cell-based-platform
#16
Ngoc D B Le, Xian Wang, Yingying Geng, Rui Tang, Gulen Yesilbag Tonga, Ziwen Jiang, Vincent M Rotello
Endocrine disrupting chemicals (EDCs) interact with estrogen receptors (ERs), causing a broad range of adverse health effects. Current assays for EDC activity are slow and often lack sensitivity. We report here an ultra-sensitive nanosensor that can detect estrogenic cellular changes in ER(+) MCF-7 cells rapidly (minutes) at several orders of magnitude lower than the generally used assays. Notably, the sensor responses at these ultra-low EDC levels correlated with an increased synthesis phase (S-phase) cell population of EDC-treated cells...
July 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28734250/assessment-of-direct-exposure-and-leaching-risk-from-pahs-in-roadway-and-stormwater-system-residuals
#17
Edmund Azah, Hwidong Kim, Timothy Townsend
Wastes generated from municipal cleaning activities such as street sweeping, ditch cleaning, stormwater pond maintenance, and catch basin sediment removal require appropriate management. Beneficial use of these types of waste is a good alternative to landfilling; however, there are genuine concerns about possible soil and groundwater contamination by pollutants such as polycyclic aromatic hydrocarbons (PAHs). This study assessed the potential risks associated with beneficial use of roadway and stormwater system residuals collected from 14 cities across the state of Florida, USA...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28730822/distributions-of-polycyclic-aromatic-hydrocarbons-aromatic-ketones-carboxylic-acids-and-trace-metals-in-arctic-aerosols-long-range-atmospheric-transport-photochemical-degradation-production-at-polar-sunrise
#18
Dharmendra Kumar Singh, Kimitaka Kawamura, Ayako Yanase, Leonard A Barrie
The distributions, correlations, and source apportionment of aromatic acids, aromatic ketones, polycyclic aromatic hydrocarbons (PAHs), and trace metals were studied in Canadian high Arctic aerosols. Nineteen PAHs including minor sulfur-containing heterocyclic PAH (dibenzothiophene) and major 6 carcinogenic PAHs were detected with a high proportion of fluoranthene followed by benzo[k]fluoranthene, pyrene, and chrysene. However, in the sunlit period of spring, their concentrations significantly declined likely due to photochemical decomposition...
August 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28725931/seasonal-trend-of-pahs-concentrations-in-farmed-mussels-from-the-coastal-areas-of-the-naples-italy
#19
Mauro Esposito, Monia Perugini, Sara Lambiase, Annamaria Conte, Loredana Baldi, Michele Amorena
This paper reports on the results about the chemical pollution pressure in the Gulf of Naples and nearby coastal areas. Farmed mussels were analysed for the presence of polycyclic aromatic hydrocarbons (PAHs). The results documented a decreasing trend in the PAHs levels respect to the past years. The Bay of Pozzuoli remains as the most contaminated site within the Lucrino area with the highest reported number of samples exceeding the benzo(a)pyrene and PAHs sum limits. All the samples with concentrations above the European regulatory limit were collected in the winter period illustrating a seasonal trend of PAHs distribution in mussels during the 4 years investigated...
July 19, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28723623/daurinol-blocks-breast-and-lung-cancer-metastasis-and-development-by-inhibition-of-focal-adhesion-kinase-fak
#20
Jong K Woo, Hyun J Jung, Ji-Youn Park, Ju-Hee Kang, Byung I Lee, DongYun Shin, Chu W Nho, Soo-Young Cho, Je K Seong, Seung H Oh
FAK overexpression has been reported in diverse primary and metastatic tumor tissues, supporting its pro-tumorigenic and pro-metastatic roles. Therefore, we have developed a neo-treatment strategy using daurinol to effectively treat cancer metastasis. Daurinol blocked cancer cell migration and invasion in vitro and exhibited anti-metastatic activity in an experimental metastasis model of breast and lung cancer. Daurinol selectively inhibited phosphorylation of FAK at Tyr925, Tyr576/577, and Tyr397 sites in a dose- and time-dependent manner...
July 4, 2017: Oncotarget
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