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Benzo(a)pyrene

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https://www.readbyqxmd.com/read/28345827/polycyclic-aromatic-hydrocarbons-in-edible-mushrooms-from-niger-delta-nigeria-carcinogenic-and-non-carcinogenic-health-risk-assessment
#1
Sorbari Igbiri, Nnaemeka Arinze Udowelle, Osazuwa Clinton Ekhator, Rose Ngozi Asomugha, Zelinjo Nkeiruka Igweze, Orish Ebere Orisakwe
In the oil-rich Niger Delta, hydrocarbon pollution and oil spillages, gas flaring and sundry anthropogenic activities constitute sources of polycyclic aromatic hydrocarbons (PAHs), with food contamination playing a major role in human exposure. In this study we assessed PAH levels in wild and cultivated edible mushroom species consumed by the general population from the oil producing Niger Delta, Nigeria. The concentrations of USEPA-16 PAHs were determined by gas chromatography and carcinogenic and non-carcinogenic health risks were calculated...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28343715/occurrence-profiles-and-toxic-equivalents-of-chlorinated-and-brominated-polycyclic-aromatic-hydrocarbons-in-e-waste-open-burning-soils
#2
Chiya Nishimura, Yuichi Horii, Shuhei Tanaka, Kwadwo Ansong Asante, Florencio Ballesteros, Pham Hung Viet, Takaaki Itai, Hidetaka Takigami, Shinsuke Tanabe, Takashi Fujimori
We conducted this study to assess the occurrence, profiles, and toxicity of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) and brominated polycyclic aromatic hydrocarbons (Br-PAHs) in e-waste open burning soils (EOBS). In this study, concentrations of 15 PAHs, 26 Cl-PAHs and 14 Br-PAHs were analyzed in EOBS samples. We found that e-waste open burning is an important emission source of Cl-PAHs and Br-PAHs as well as PAHs. Concentrations of total Cl-PAHs and Br-PAHs in e-waste open burning soil samples ranged from 21 to 2800 ng/g and from 5...
March 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28341327/importance-of-the-structure-and-nanoporosity-of-organic-matter-on-the-desorption-kinetics-of-benzo-a-pyrene-in-sediments
#3
Youda Huang, Dainan Zhang, Dandan Duan, Yu Yang, Yongqiang Xiong, Yong Ran
The desorption kinetics and mechanism were investigated using a Tenax extraction technique on different sediments spiked with radiocarbon-labeled benzo[a]pyrene (BaP). Five sedimentary fractions were sequentially fractionated, and the only nonhydrolyzable organic carbon fractions (NHC) were characterized using advanced solid-state (13)C nuclear magnetic resonance spectroscopy (NMR), improved six end-member model, and a CO2 gas adsorption technique. The sediments contained high percentages of algaenan and/or sporopollenin but low percentages of black carbon and lignin...
March 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28341215/identification-and-molecular-characterization-of-cytochrome-p450-cyp450-family-genes-in-the-marine-ciliate-euplotes-crassus-the-effect-of-benzo-a-pyrene-and-beta-naphthoflavone
#4
Bora Yim, Hokyun Kim, Jisoo Kim, Haeyeon Kim, Eun-Ji Won, Young-Mi Lee
Marine ciliate Euplotes crassus, a single-cell eukaryote, and has been considered as a model organism for monitoring of environmental pollutions in sediments. Cytochrome P450 (CYP450) monooxygenase are phase I enzyme involved in detoxification of environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs). However, little information on CYP450 family genes in ciliate is available. In the present study, acute toxicity of PAH, benzo[a]pyrene (B[a]P) and PAH-like model compound, beta-naphthoflavone (β-NF), was investigated; full-length cDNA sequences and genomic structure of five CYP450 genes (CYP5680A1, CYP5681A1, CYP5681B1, CYP5682A1, and CYP5683A1) were analyzed; and finally their activities and transcriptional changes were measured after exposure to PAHs for 48h...
March 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28340792/in-situ-quantitative-and-visual-investigation-of-the-retention-of-polycyclic-aromatic-hydrocarbons-on-the-root-surface-of-kandelia-obovata-using-a-microscopic-fluorescence-spectral-analysis-method
#5
Huadong Tan, Ruilong Li, Yaxian Zhu, Yong Zhang
A novel approach for in situ determination of individual benzo[a]pyrene (B[a]P), pyrene (Pyr) and anthracene (Ant) on the root surface micro-zone (0.960mm(2)) of Kandelia obovata (K. obovata) was established using a microscopic fluorescence spectral analysis (MFSA) system. The detection limits for the three polycyclic aromatic hydrocarbons (PAHs) were 44.2, 59.7 and 36.3ngg(-1) on lateral roots and were 42.8, 62.4 and 39.1ngg(-1) on taproots of the K. obovata root micro-zone. Using the established MFSA method, retention of the PAHs on the K...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340763/a-preconcentrator-separator-two-in-one-online-system-for-polycyclic-aromatic-hydrocarbons-analysis
#6
Charinrat Siritham, Chongdee Thammakhet-Buranachai, Panote Thavarungkul, Proespichaya Kanatharana
A novel preconcentrator-separator two-in-one online system has been developed for the online analysis of trace amounts of four polycyclic aromatic hydrocarbons (PAHs) in tea samples. A micro-preconcentrator unit of zeolite imidazolate framework-8-poly(vinyl alcohol) cryogel (ZIF-8-PVA cryogel) and a micro-separation unit of multiwalled carbon nanotubes-poly(vinyl alcohol) cryogel (MWCNTs-PVA cryogel) were fabricated onto an acrylic plate. The eluent from this two-in-one system flowed directly to an on-column UV-visible detector...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28332173/combined-ultrasound-with-fenton-treatment-for-the-degradation-of-carcinogenic-polycyclic-aromatic-hydrocarbons-in-textile-dying-sludge
#7
Jian-Hao Zhang, Hai-Yuan Zou, Xun-An Ning, Mei-Qing Lin, Chang-Min Chen, Tai-Cheng An, Jian Sun
To develop an effective method to remove the toxic and carcinogenic polycyclic aromatic hydrocarbons (CPAHs) from textile dyeing sludge, five CPAHs were selected to investigate the degradation efficiencies using ultrasound combined with Fenton process (US/Fenton). The results showed that the synergistic effect of the US/Fenton process on the degradation of CPAHs in textile dyeing sludge was significant with the synergy degree of 30.4. During the US/Fenton process, low ultrasonic density showed significant advantage in degrading the CPAHs in textile dyeing sludge...
March 22, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28332138/benzo-a-pyrene-exposure-causes-genotoxic-and-biochemical-changes-in-the-midge-larvae-of-chironomus-sancticaroli-strixino-strixino-diptera-chironomidae
#8
M Vicentini, G S Morais, D Rebechi-Baggio, V S Richardi, G S Santos, M M Cestari, M A Navarro-Silva
Benzo(a)pyrene (BaP) is a carcinogenic polycyclic aromatic hydrocarbon, also found in nature due to human activities. BaP adheres to sediments showing toxic effects on benthic organisms, including midge larvae of the family Chironomidae. We tested for toxic effects of benzo(a)pyrene on Chironomus sancticaroli Strixino & Strixino 1981 using biochemical and genotoxic biomarkers, to identify changes in metabolic and antioxidant pathways, besides neurotoxic and DNA damage. Enzyme activity was compared by exposing larvae to four nominal concentrations (0...
March 22, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28329817/early-life-benzo-a-pyrene-exposure-causes-neurodegenerative-syndromes-in-adult-zebrafish-danio-rerio-and-the-mechanism-involved
#9
Dongxu Gao, Chonggang Wang, Zhihui Xi, Yixi Zhou, Yuanchuan Wang, Zhenghong Zuo
There is increasing recognition of the importance of early-life environmental exposures in health disorders at later-life stages. The aim of this study was to evaluate whether early-life exposure to benzo[a]pyrene (BaP) could induce neurodegenerative syndromes at later-life stages in zebrafish. Embryos were exposed to BaP at doses of 0, 0.05, 0.5, 5, and 50 nM from early embryogenesis to 96 h post-fertilization (hpf), then transferred to clean water and maintained for 365 days. We found that BaP decreased locomotor and cognitive ability, neurotransmitter levels of dopamine, 3,4-dihydroxyphenylacetic acid and norepinephrine; and induced loss of dopaminergic neurons and resulted in neurodegeneration...
January 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28327162/biological-effects-of-carbon-black-nanoparticles-are-changed-by-surface-coating-with-polycyclic-aromatic-hydrocarbons
#10
Karina Lindner, Michael Ströbele, Sandra Schlick, Sina Webering, André Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Hüttmann, Holger Heine, Henning Bockhorn, Tanja Hansen, Peter König, Heinz Fehrenbach
BACKGROUND: Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and through adsorbing intrinsically toxic substances, such as polycyclic aromatic hydrocarbons (PAH). It is not clear whether a PAH surface coating changes the toxicological properties of CBNP by influencing their physicochemical properties, through the specific toxicity of the surface-bound PAH, or by a combination of both...
March 21, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28325086/application-of-bacterial-reverse-mutation-assay-for-detection-of-non-genotoxic-carcinogens
#11
Rewan Kanode, Saurabh Chandra, Sharad Sharma
Non-genotoxic carcinogens may play a significant role in development of cancer. Currently short-term assays for mutagenicity classify genotoxic carcinogens and lack the abilities to detect epigenetic carcinogens. The need to develop an endpoint always remains to recognize potentially carcinogenic agents employing rapid and practical bioassays. For this, the present study utilized TA98 and TA1537 tester strains of Salmonella typhimurium to evaluate four non-genotoxic carcinogenic agents (Coumarin, β-Myrcene, Bis(2-ethylhexyl) phthalate and trans-anethole)...
March 22, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28319121/growth-altering-microbial-interactions-are-responsive-to-chemical-context
#12
Angela Liu, Anne M Archer, Matthew B Biggs, Jason A Papin
Microbial interactions are ubiquitous in nature, and are equally as relevant to human wellbeing as the identities of the interacting microbes. However, microbial interactions are difficult to measure and characterize. Furthermore, there is growing evidence that they are not fixed, but dependent on environmental context. We present a novel workflow for inferring microbial interactions that integrates semi-automated image analysis with a colony stamping mechanism, with the overall effect of improving throughput and reproducibility of colony interaction assays...
2017: PloS One
https://www.readbyqxmd.com/read/28315931/polycyclic-aromatic-hydrocarbons-in-mussels-from-a-south-american-estuary
#13
Ana L Oliva, Andrés H Arias, Pamela Y Quintas, Natalia S Buzzi, Jorge E Marcovecchio
Bivalves, especially mussels, have been pointed as putative species to monitor polycyclic aromatic hydrocarbons (PAHs) in marine environment. After several environmental PAHs baseline reports, the present study was conducted to assess for the first time the levels of PAHs in native mussels (Brachidontes rodriguezii) collected from a critical industrialized estuary of Argentina. Under this objective, after an 18-month sampling period, 34 pools of mussels were assessed for 17 PAHs, including the 16 compounds prioritized by United States Environmental Protection Agency...
March 18, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28314140/an-investigation-of-the-immunotoxicity-of-oil-sands-processed-water-and-leachates-in-trout-leukocytes
#14
F Gagné, A Bruneau, P Turcotte, C Gagnon, E Lacaze
Increased oil sands (OS) mining activity has raised concerns about impacts on aquatic organisms. This study sought to examine the effects of single representative compounds from OS (benzo(a)pyrene, naphthalene), a mixture of naphthenic acids (NAs), OS-processed water (OSPW) and OS leachate (OSL) extracts on rainbow trout leukocytes. Primary cultures of trout leukocytes were exposed to increasing concentrations of benzo(a)pyrene, naphthalene, NAs, OSPW and OSL for 48h at 18°C. Immunocompetence was followed by measuring changes in lymphocyte and macrophage viability and phagocytosis...
March 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28314123/which-persistent-organic-pollutants-in-the-rivers-of-the-bohai-region-of-china-represent-the-greatest-risk-to-the-local-ecosystem
#15
Yueqing Zhang, Andrew C Johnson, Chao Su, Meng Zhang, Monika D Jürgens, Yajuan Shi, Yonglong Lu
Freshwater aquatic organisms can be exposed to hundreds of persistent organic pollutants (POPs) discharged by natural and anthropogenic activities. Given our limited resources it is necessary to identify, from the existing evidence, which is the greatest threat so that control measures can be targeted wisely. The focus of this study was to rank POPs according to the relative risk they represent for aquatic organisms in rivers in the Bohai Region, China. A list of 14 POPs was compiled based on the available data on their presence in these rivers and ecotoxicological data...
February 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28304160/nucleosome-histone-tail-conformation-and-dynamics-impacts-of-lysine-acetylation-and-a-nearby-minor-groove-benzo-a-pyrene-derived-lesion
#16
Iwen Fu, Yuqin Cai, Nicholas E Geacintov, Yingkai Zhang, Suse Broyde
Histone tails in nucleosomes play critical roles in regulation of many biological processes, including chromatin compaction, transcription, and DNA repair. Moreover, post-translational modifications, notably lysine acetylation, are crucial to these functions. While the tails have been intensively studied, how the structures and dynamics of tails are impacted by the presence of a nearby bulky DNA lesion is a frontier research area, and how these properties are impacted by tail lysine acetylation remains unexplored...
March 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28298645/role-for-the-atpase-inhibitory-factor-1-in-the-environmental-carcinogen-induced-warburg-phenotype
#17
Kévin Hardonnière, Morgane Fernier, Isabelle Gallais, Baharia Mograbi, Normand Podechard, Eric Le Ferrec, Nathalie Grova, Brice Appenzeller, Agnès Burel, Martine Chevanne, Odile Sergent, Laurence Huc, Sylvie Bortoli, Dominique Lagadic-Gossmann
Most tumors undergo metabolic reprogramming towards glycolysis, the so-called Warburg effect, to support growth and survival. Overexpression of IF1, the physiological inhibitor of the F0F1ATPase, has been related to this phenomenon and appears to be a relevant marker in cancer. Environmental contributions to cancer development are now widely accepted but little is known about the underlying intracellular mechanisms. Among the environmental pollutants humans are commonly exposed to, benzo[a]pyrene (B[a]P), the prototype molecule of polycyclic aromatic hydrocarbons (PAHs), is a well-known human carcinogen...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290727/the-toxic-effects-of-benzo-a-pyrene-on-activated-mouse-t-cells-in-vitro
#18
Shuang Guan, Yixuan Huang, Zhe Feng, Linli Xu, Yingli Jin, Jing Lu
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon contaminant that is widely present in environmental sources, including food. This study aims to clarify the effects of B[a]P toxicity on activated mouse T cells in vitro. Our results show that B[a]P markedly inhibited Concanavalin A (ConA)-induced T lymphocyte proliferation and suppressed the production of the cytokines Interferon (IFN)-γ, Interleukin (IL)-2 and IL-4. Western blot and protein-DNA interaction assays were used to study how B[a]P affects signal transduction...
March 14, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28284726/endocrine-disrupting-compounds-modulates-adiponectin-secretion-expression-of-its-receptors-and-action-on-steroidogenesis-in-ovarian-follicle
#19
Agnieszka Rak, Karolina Zajda, Ewa Łucja Gregoraszczuk
We determined the effect of dioxin-like polychlorinated naphtalenes (PCN) (Halowax 1051) (100pg/ml), benzo(a)pyrene [B(a)P] (2.5ng/ml), hexachlorobenzene (HCBz) (0.2ng/ml) and non-dioxin like polybrominated diphenyl ether (BDE-47) (25ng/ml) and bisphenol A (BPA) (20ng/ml) on ovarian adiponectin secretion (ELISA) and its receptors expression (Western blot). Ovarian cells co-culture was used to examine action of endocrine disruptors (EDCs) on adiponectin (10μg/ml) stimulated steroidogenesis. B(a)P, HCBz, testosterone (T) decreased adiponectin secretion and receptors expression, BPA, BDE-47, estradiol (E2) had the opposite effect, while PCN had inhibitory effect only on adiponectin secretion...
March 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28284555/reduction-in-population-exposure-to-pm2-5-and-cancer-risk-due-to-pm2-5-bound-pahs-exposure-in-beijing-china-during-the-apec-meeting
#20
Yangyang Xie, Bin Zhao, Yuejing Zhao, Qinzi Luo, Shuxiao Wang, Bin Zhao, Shunhua Bai
Radical measures for controlling ambient air pollution sources were employed by the Chinese government during the Asia-Pacific Economic Cooperation (APEC) meeting in 2014, providing a unique case to evaluate the health effect benefits from such measures. To examine the cancer risk reduction from the source control measures during the APEC meeting, we estimated the reduction in population exposure to PM2.5 and PAHs and the reduction in PAHs-associated cancer risk if the control measures were sustained over time...
March 8, 2017: Environmental Pollution
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