keyword
MENU ▼
Read by QxMD icon Read
search

Benzo(a)pyrene

keyword
https://www.readbyqxmd.com/read/28545203/influence-of-urban-vegetation-on-air-pollution-and-noise-exposure-a-case-study-in-gothenburg-sweden
#1
Jenny Klingberg, Malin Broberg, Bo Strandberg, Pontus Thorsson, Håkan Pleijel
Air pollution levels (NO2, PAHs, O3) were investigated, before (BLE) and after (ALE) leaf emergence, in the urban landscape of Gothenburg, Sweden. The aims were to study the 1) spatial and temporal variation in pollution levels between urban green areas, 2) effect of urban vegetation on air pollution levels at the same distance from a major emission source (traffic route), 3) improvement of urban air quality in urban parks compared to adjacent sites near traffic, 4) correlation between air pollution and noise in a park...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28544899/identifying-risk-sources-of-air-contamination-by-polycyclic-aromatic-hydrocarbons
#2
Jiri Huzlik, Frantisek Bozek, Adam Pawelczyk, Roman Licbinsky, Magdalena Naplavova, Michael Pondelicek
This article is directed to determining concentrations of polycyclic aromatic hydrocarbons (PAHs), which are sorbed to solid particles in the air. Pollution sources were identified on the basis of the ratio of benzo[ghi]perylene (BghiPe) to benzo[a]pyrene (BaP). Because various important information is lost by determining the simple ratio of concentrations, least squares linear regression (classic ordinary least squares regression), reduced major axis, orthogonal regression, and Kendall-Theil robust diagnostics were utilized for identification...
May 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28541831/genotoxicity-and-antigenotoxicity-assessments-of-the-flavonoid-vitexin-by-the-drosophila-melanogaster-somatic-mutation-and-recombination-test
#3
Liliane Menezes Fernandes, Zaira da Rosa Guterres, Igor Vivian Almeida, Veronica Elisa Pimenta Vicentini
Vitexin is a C-glycosylated flavone found in various medicinal plants with several proven biological properties such as anti-inflammatory, antispasmodic, antimicrobial, cytotoxic, and antioxidant activities. Considering that the human population consumes many foods that contain this flavonoid, the objective of this study was to investigate the genotoxic and the antigenotoxic potentials of vitexin by the SMART (Somatic Mutation and Recombination Test) in Drosophila melanogaster wings, in vivo. To evaluate the genotoxic activity, larvae obtained from standard (ST) and high bioactivation (HB) crosses were chronically treated with different concentrations of vitexin (0...
May 25, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28538680/diazonium-salt-based-surface-enhanced-raman-spectroscopy-nanosensor-detection-and-quantitation-of-aromatic-hydrocarbons-in-water-samples
#4
Inga Tijunelyte, Stéphanie Betelu, Jonathan Moreau, Ioannis Ignatiadis, Catherine Berho, Nathalie Lidgi-Guigui, Erwann Guénin, Catalina David, Sébastien Vergnole, Emmanuel Rinnert, Marc Lamy de la Chapelle
Here, we present a surface-enhanced Raman spectroscopy (SERS) nanosensor for environmental pollutants detection. This study was conducted on three polycyclic aromatic hydrocarbons (PAHs): benzo[a]pyrene (BaP), fluoranthene (FL), and naphthalene (NAP). SERS substrates were chemically functionalized using 4-dodecyl benzenediazonium-tetrafluoroborate and SERS analyses were conducted to detect the pollutants alone and in mixtures. Compounds were first measured in water-methanol (9:1 volume ratio) samples. Investigation on solutions containing concentrations ranging from 10(-6) g L(-1) to 10(-3) g L(-1) provided data to plot calibration curves and to determine the performance of the sensor...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28536195/discovery-of-a-widespread-metabolic-pathway-within-and-among-phenolic-xenobiotics
#5
Pahriya Ashrap, Guomao Zheng, Yi Wan, Tong Li, Wenxin Hu, Wenjuan Li, Hong Zhang, Zhaobin Zhang, Jianying Hu
Metabolism is an organism's primary defense against xenobiotics, yet it also increases the production of toxic metabolites. It is generally recognized that phenolic xenobiotics, a group of ubiquitous endocrine disruptors, undergo rapid phase II metabolism to generate more water-soluble glucuronide and sulfate conjugates as a detoxification pathway. However, the toxicological effects of the compounds invariably point to the phase I metabolic cytochrome P450 enzymes. Here we show that phenolic xenobiotics undergo an unknown metabolic pathway to form more lipophilic and bioactive products...
May 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533128/polyphenol-inhibition-of-benzo-a-pyrene-induced-oxidative-stress-and-neoplastic-transformation-in-an-in-vitro-model-of-carcinogenesis
#6
Kosar Omidian, Hossein Rafiei, Brian Bandy
While dietary polyphenols are widely recognized for cancer-preventing characteristics, the relative effectiveness and mechanisms of action of different polyphenols is not clear. In the present study, we investigated the protective effects of six different polyphenols against benzo[a]pyrene (B[a]P)-induced oxidative stress and neoplastic transformation in the Bhas 42 cell carcinogenesis assay. All of the polyphenols completely prevented the increased intracellular ROS generation by B[a]P at 12 h, and most inhibited after 3 days...
May 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28531207/benzo-a-pyrene-activates-interleukin-6-induction-and-suppresses-nitric-oxide-induced-apoptosis-in-rat-vascular-smooth-muscle-cells
#7
Huei-Ping Tzeng, Kuo-Cheng Lan, Ting-Hua Yang, Min-Ni Chung, Shing Hwa Liu
Benzo[a]pyrene, a ubiquitous environmental pollutant, has been suggested to be capable of initiating and/or accelerating atherosclerosis. Accumulation of vascular smooth muscle cells (VSMCs) in vessel intima is a hallmark of atherosclerosis. Nitric oxide (NO) can suppress VSMCs proliferation and induce VSMCs apoptosis. NO plays a compensatory role in the vascular lesions to reduce proliferation and/or accelerate apoptosis of VSMCs. The aim of this study was to investigate whether benzo[a]pyrene can affect VSMCs growth and apoptosis induced by NO...
2017: PloS One
https://www.readbyqxmd.com/read/28529061/benzo-a-pyrene-7-8-diol-9-10-epoxide-suppresses-the-migration-and-invasion-of-human-extravillous-trophoblast-htr-8-svneo-cells-by-down-regulating-mmp2-through-inhibition-of-fak-src-pi3k-akt-pathway
#8
Rong Wang, Weiping Wang, Lin Ao, Zhi Wang, Xianglin Hao, Huidong Zhang
Moderate invasion of trophoblasts into the endometrium is crucial for successful pregnancy. Benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) is a carcinogenic metabolite of benzo[a]pyrene which causes various diseases. We investigated the effects of BPDE on migration and invasion of trophoblast HTR-8/SVneo cells. Migration and invasion of cells exposed to 0.25-1.0μM BPDE for 24h were significantly inhibited. Moreover, tube formation of human umbilical vein endothelial cell (HUVEC) was also significantly reduced after incubation with HTR-8/SVneo cells treated with 0...
May 18, 2017: Toxicology
https://www.readbyqxmd.com/read/28527150/development-of-in-silico-protocols-to-predict-structural-insights-into-the-metabolic-activation-pathways-of-xenobiotics
#9
M Kalim A Khan, Salman Akhtar, Jamal M Arif
To establish in silico model to predict the structural insight into the metabolic bioactivation pathway of xenobiotics, we considered two specific and one non-specific mammary procarcinogen [e.g., dibenzo[a,l]pyrene (DBP), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (BP)]. The CYP1A1, 1B1, 2C9, 1A2 and 2B6 reported in wet-lab studies to actively metabolize DBP also showed strong binding energies (kcal/mol) of -11.50, -10.67, -10.37, -9.76 and -9.72, respectively, with inhibition constants ranging between 0...
May 19, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28524104/dietary-intake-of-meat-cooking-related-mutagens-hcas-and-risk-of-colorectal-adenoma-and-cancer-a-systematic-review-and-meta-analysis
#10
Manuela Chiavarini, Gaia Bertarelli, Liliana Minelli, Roberto Fabiani
Much evidence suggests that the positive association between meat intake and colorectal adenoma (CRA) and cancer (CRC) risk is mediated by mutagenic compounds generated during cooking at high temperature. A number of epidemiological studies have estimated the effect of meat-related mutagens intake on CRC/CRA risk with contradictory and sometimes inconsistent results. A literature search was carried out (PubMed, Web of Science and Scopus) to identify articles reporting the relationship between the intake of meat-related mutagens (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline: DiMeIQx, benzo(a) pyrene (B(a)P) and "meat derived mutagenic activity" (MDM)) and CRC/CRA risk...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28522830/inhibition-of-endocytic-lipid-antigen-presentation-by-common-lipophilic-environmental-pollutants
#11
Manju Sharma, Xiang Zhang, Shuangmin Zhang, Liang Niu, Shuk-Mei Ho, Aimin Chen, Shouxiong Huang
Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants. To test this notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust particles impact on the activation of lipid-specific T cells. Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28513332/a-fit-for-purpose-method-to-monitor-16-eu-pahs-in-food-results-of-five-years-official-food-control-in-two-italian-regions
#12
Carmela Lestingi, Tamara Tavoloni, Valentina Bardeggia, Monia Perugini, Arianna Piersanti
A gas-chromatographic single quadrupole analytical method for the analysis of the sixteen priority EU polycyclic aromatic hydrocarbons (PAHs) in food is presented in this paper. The method fulfils the request of Regulation EU 836/2011 for an analytical procedure to be used for official control of PAHs in food, in EU member states. The sample preparation involves a Pressurised Liquid Extraction (PLE) with an in-cell clean-up step followed by a lipid removal using SPE on a styrene divinylbenzene stationary phase (SDVB) and a final gel permeation chromatography (GPC) step...
May 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28511592/cytotoxicity-mutagenicity-and-antimutagenicity-of-the-gentisic-acid-on-htc-cells
#13
Flavia Maria Lima Cavalcante, Igor Vivian Almeida, Elisângela Düsman, Mário Sérgio Mantovani, Veronica Elisa Pimenta Vicentini
Gentisic acid (GA) exhibits antioxidant, anti-inflammatory, and antibiotic activities. This substance can be found in citrus fruits, grapes, olive oil, and peas. Considering that there are few studies in the literature on the toxicity of GA, the present work aimed to investigate its cytotoxic, mutagenic, and antimutagenic activities on HTC cells. GA was diluted in culture medium at the final concentration of 0.08, 0.16, 0.8, 1.6, and 8 μg/mL. The cytotoxicity was determined by the MTT assay and Trypan Blue exclusion method, with methyl methanesulfonate and doxorubicin as positive controls, respectively...
May 16, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28511186/search-for-internal-cancers-in-mice-tattooed-with-inks-of-high-contents-of-potential-carcinogens-a-one-year-autopsy-study-of-red-and-black-tattoo-inks-banned-in-the-market
#14
Mitra Sepehri, Catharina M Lerche, Katrina Hutton Carlsen, Jørgen Serup
BACKGROUND AND OBJECTIVE: Tattoo ink stock products often contain potential carcinogens, which on large-scale population exposure may be clinically relevant. The aim of this autopsy study in mice was to screen major organs for clinical and subclinical cancers. METHODS: Mice were tattooed on their backs. In total, 48 mice were included and divided into 4 groups; 11 mice tattooed black, 10 tattooed red, and 5 mice serving as untreated controls. A group of 22 mice with black tattoos and exposed to ultraviolet radiation (UVR) were also studied...
May 17, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28502747/chicken-egg-fetal-liver-dna-and-histopathologic-effects-of-structurally-diverse-carcinogens-and-non-carcinogens
#15
M J Iatropoulos, T Kobets, J-D Duan, K D Brunnemann, E Vock, U Deschl, G M Williams
Chicken egg fetal livers were evaluated for histopathological changes produced by four genotoxic hepatocarcinogens: 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (BaP), diethylnitrosamine (DEN); four structurally related non- or weakly- carcinogenic comparators: fluorene (FLU), aflatoxin B2 (AFB2), benzo[e]pyrene (BeP), N-nitrosodiethanolamine (NDELA); two epigenetic hepatocarcinogens: clofibric acid (CFA), phenobarbital (PB); and the non-carcinogen, D-mannitol (MAN). CFA, PB and MAN were also assessed for formation of DNA adducts using the (32)P nucleotide postlabeling (NPL) assay and for DNA breaks using the comet assay...
May 11, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28497299/ecotoxicological-and-health-risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-short-neck-clam-paphia-undulata-and-contaminated-sediments-in-malacca-strait-malaysia
#16
Mehrzad Keshavarzifard, Mohamad Pauzi Zakaria, Reza Sharifi
The distribution, sources, and human health risk assessment of polycyclic aromatic hydrocarbons (PAHs) in surface sediment and the edible tissue of short-neck clam (Paphia undulata) from mudflat ecosystem in the west coast of Malaysia were investigated. The concentrations of ∑16 PAHs varied from 347.05 to 6207.5 and 179.32 to 1657.5 ng g(-1) in sediment and short-neck clam samples, respectively. The calculations of mean PEL quotients (mean-PELQs) showed that the ecological risk of PAHs in the sediment samples was low to moderate-high level, whereas the total health risk through ingestion and dermal contact was considerably high...
May 11, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28487163/a-multi-year-study-of-hepatic-biomarkers-in-coastal-fishes-from-the-gulf-of-mexico-after-the-deepwater-horizon-oil-spill
#17
Marci Smeltz, Laura Rowland-Faux, Céline Ghiran, William F Patterson, Steven B Garner, Alan Beers, Quentin Mièvre, Andrew S Kane, Margaret O James
Following the 2010 Gulf of Mexico oil spill, concerns were raised regarding exposure of fish to crude oil components, particularly polycyclic aromatic hydrocarbons (PAHs). This three year study examined hepatic enzymes in post-mitochondrial supernatant fractions from red snapper (Lutjanus campechanus) and gray triggerfish (Balistes capriscus) collected in the north central Gulf of Mexico between 2011 and 2014. Biomarker activities evaluated included benzo(a)pyrene hydroxylase (AHH), ethoxyresorufin O-deethylase (EROD), glutathione transferase (GST), and glutathione peroxidase (GPx)...
April 27, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28486571/ras-oncogene-and-hypoxia-inducible-factor-1-alpha-hif-1%C3%AE-expression-in-the-amazon-fish-colossoma-macropomum-cuvier-1818-exposed-to-benzo-a-pyrene
#18
Grazyelle Sebrenski da Silva, Luciana Mara Lopes Fé, Maria de Nazaré Paula da Silva, Vera Maria Fonseca de Almeida E Val
Benzo[a]pyrene (B[a]P) is a petroleum derivative capable of inducing cancer in human and animals. In this work, under laboratory conditions, we analyzed the responses of Colossoma macropomum to B[a]P acute exposure through intraperitoneal injection of four different B[a]P concentrations (4, 8, 16 and 32 μmol/kg) or corn oil (control group). We analyzed expression of the ras oncogene and the Hypoxia-inducible factor-1 alpha (hif-1α) gene using quantitative real-time PCR. Additionally, liver histopathological changes and genotoxic effects were evaluated through the comet assay...
May 8, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28482185/effect-of-exposure-to-polycyclic-aromatic-hydrocarbons-on-basal-ganglia-and-attention-deficit-hyperactivity-disorder-symptoms-in-primary-school-children
#19
Marion Mortamais, Jesus Pujol, Barend L van Drooge, Didac Macià, Gerard Martínez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been proposed as environmental risk factors for attention deficit hyperactivity disorder (ADHD). The effects of these pollutants on brain structures potentially involved in the pathophysiology of ADHD are unknown. OBJECTIVE: The aim of this study was to investigate the effects of PAHs on basal ganglia volumes and ADHD symptoms in school children. METHODS: We conducted an imaging study in 242 children aged 8-12years, recruited through a set of representative schools of the city of Barcelona, Spain...
May 5, 2017: Environment International
https://www.readbyqxmd.com/read/28481324/chemical-characterization-of-the-indoor-air-quality-of-a-university-hospital-penetration-of-outdoor-air-pollutants
#20
Paul T J Scheepers, Luuk Van Wel, Gwendolyn Beckmann, Rob B M Anzion
For healthcare centers, local outdoor sources of air pollution represent a potential threat to indoor air quality (IAQ). The aim of this study was to study the impact of local outdoor sources of air pollution on the IAQ of a university hospital. IAQ was characterized at thirteen indoor and two outdoor locations and source samples were collected from a helicopter and an emergency power supply. Volatile organic compounds (VOC), acrolein, formaldehyde, nitrogen dioxide (NO₂), respirable particulate matter (PM-4...
May 8, 2017: International Journal of Environmental Research and Public Health
keyword
keyword
79596
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"