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Benzo(a)pyrene

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https://www.readbyqxmd.com/read/28102315/methyl-cytosine-driven-structural-changes-enhance-adduction-kinetics-of-an-exon-7-fragment-of-the-p53-gene
#1
Spundana Malla, Karteek Kadimisetty, You-Jun Fu, Dharamainder Choudhary, John B Schenkman, James F Rusling
Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards electrophiles. Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions are in turn correlated with specific cancers. Here we describe the first restriction-enzyme-assisted LC-MS/MS sequencing study of the influence of methyl cytosines (MeC) on kinetics of p53 gene adduction by model metabolite benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), using methodology applicable to correlate gene damage sites for drug and pollutant metabolites with mutation sites...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101199/ultrastructural-changes-during-lung-carcinogenesis-modulation-by-curcumin-and-quercetin
#2
Xin Wang, Lei Wang, Hao Zhang, Ke Li, Jiqin You
The aim of the present study was to examine the effectiveness of curcumin and quercetin in modulating ultrastructural changes during lung carcinogenesis. A total of 24 male laka mice were divided into the normal control, benzo[a]pyrene (BP)-treated, BP+curcumin-treated, BP+quercetin- treated, and BP+curcumin+quercetin-treated groups (n=6 per group). Lung carcinogenesis was induced by a single intraperitoneal injection of BP [100 mg/kg of body weight (b.wt.)]. Curcumin was supplemented to mice at a dose level of 60 mg/kg of b...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100150/polycyclic-aromatic-hydrocarbon-levels-and-risk-assessment-for-food-from-service-facilities-in-korea
#3
Shin-Woong Park, Jun-Hyun Jeong, Jae-Young Her, Mina K Kim, Kwang-Geun Lee
In this study levels of benzo[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenzo[a,h]anthracene, benzo[g,h,i]perylene and indeno[1,2,3-c,d]pyrene in 412 food items collected from food service facilities in Korea were analyzed. The concentrations of the 8 polycyclic aromatic hydrocarbons (PAHs) ranged 0.13-0.48 μg/kg. The concentrations of benzo[a]pyrene in all food samples were <1 μg/kg, which is the lowest maximum limit in foods regulated by EU legislation. PAH contents were employed to conduct exposure and risk assessment...
January 19, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28100131/influence-of-activated-sewage-sludge-amendment-on-pahs-removal-efficiency-from-a-naturally-contaminated-soil-application-of-the-landfarming-treatment
#4
Borislava Lukić, David Huguenot, Antonio Panico, Eric D van Hullebusch, Giovanni Esposito
The removal of polycyclic aromatic hydrocarbons (PAHs) from a naturally co-contaminated soil by PAHs and heavy metals with an initial concentration of 620 mg of total PAHs kg(-1) dry soil was investigated. The efficiency of landfarming in removing phenanthrene, pyrene, benzo(a)pyrene and the group of total 16 US EPA PAHs was evaluated. The process was biostimulated by adding centrifuged activated sewage sludge (SS) as an organic amendment. Experimental activities were conducted in four laboratory scale reactors filled with corn cobs as bulking agent to reach bulk density of 640 kg/m(3)...
January 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28092946/carcinogenesis-of-the-oral-cavity-environmental-causes-and-potential-prevention-by-black-raspberry
#5
Karam El-Bayoumy, Kun-Ming Chen, Shang-Min Zhang, Yuan-Wan Sun, Shantu Amin, Gary Stoner, Joseph B Guttenplan
Worldwide, cancers of the oral cavity and pharynx comprise the sixth most common malignancies. Histologically, more than 90% of oral cancers are squamous cell carcinoma (SCC). Epidemiologic data strongly support the role of exogenous factors such as tobacco, alcohol, and human papilloma virus infection as major causative agents. Avoidance of risk factors has only been partially successful, and survival rates have not improved despite advances in therapeutic approaches. Therefore, new or improved approaches to prevention and/or early detection are critical...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28088583/environmental-carcinogenesis-and-ph-homeostasis-not-only-a-matter-of-dysregulated-metabolism
#6
REVIEW
Kévin Hardonnière, Laurence Huc, Odile Sergent, Jørn A Holme, Dominique Lagadic-Gossmann
According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined...
January 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28069128/on-line-mspd-spe-hplc-fld-analysis-of-polycyclic-aromatic-hydrocarbons-in-bovine-tissues
#7
Tania M Gutiérrez-Valencia, Martha P García de Llasera
A fast method was optimized and validated for simultaneous trace determination of four polycyclic aromatic hydrocarbons: benzo[a]anthracene, benzo[b]fluoranthene, benzo[k]fluoranthene and benzo[a]pyrene in bovine tissues. The determination was performed by matrix solid-phase dispersion (MSPD) coupled on-line to solid phase extraction (SPE) and high performance liquid chromatography (HPLC) with fluorescence detection (FLD). The sample was dispersed on C18 silica sorbent and then the on-line MSPD-SPE-HPLC/FLD method was applied...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28065544/solar-radiation-as-a-swift-pathway-for-pah-photodegradation-a-field-study
#8
Montse Marquès, Montse Mari, Jordi Sierra, Martí Nadal, José L Domingo
The photodegradation of polycyclic aromatic hydrocarbons (PAHs) may be an important degradation pathway of PAHs in regions with a high solar radiation. The present investigation was aimed at studying the photodegradation of PAHs after their deposition on surface soils with different textures. Photodegradation by-products were also identified and semi-quantified, as well as correlated with the decrease of parent compounds. The experiment was performed by deploying soil samples spiked with a mixture of the 16 US EPA priority PAHs in a methacrylate box, exposed to solar radiation for 7days, meaning a solar energy of 102...
January 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28065385/processing-of-the-abasic-sites-clustered-with-the-benzo-a-pyrene-adducts-by-the-base-excision-repair-enzymes
#9
Lidia V Starostenko, Nadejda I Rechkunova, Natalia A Lebedeva, Alexander A Lomzov, Vladimir V Koval, Olga I Lavrik
The major enzyme in eukaryotic cells that catalyzes the cleavage of apurinic/apyrimidinic (AP or abasic) sites is AP endonuclease 1 (APE1) that cleaves the phosphodiester bond on the 5'-side of AP sites. We found that the efficiency of AP site cleavage by APE1 was affected by the benzo[a]pyrenyl-DNA adduct (BPDE-dG) in the opposite strand. AP sites directly opposite of the modified dG or shifted toward the 5' direction were hydrolyzed by APE1 with an efficiency moderately lower than the AP site in the control DNA duplex, whereas AP sites shifted toward the 3' direction were hydrolyzed significantly less efficiently...
December 27, 2016: DNA Repair
https://www.readbyqxmd.com/read/28063314/construction-of-pah-degrading-mixed-microbial-consortia-by-induced-selection-in-soil
#10
German Zafra, Ángel E Absalón, Miguel Ángel Anducho-Reyes, Francisco J Fernandez, Diana V Cortés-Espinosa
Bioremediation of polycyclic aromatic hydrocarbons (PAHs)-contaminated soils through the biostimulation and bioaugmentation processes can be a strategy for the clean-up of oil spills and environmental accidents. In this work, an induced microbial selection method using PAH-polluted soils was successfully used to construct two microbial consortia exhibiting high degradation levels of low and high molecular weight PAHs. Six fungal and seven bacterial native strains were used to construct mixed consortia with the ability to tolerate high amounts of phenanthrene (Phe), pyrene (Pyr) and benzo(a)pyrene (BaP) and utilize these compounds as a sole carbon source...
December 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/28063149/modulation-of-benzo-a-pyrene-induced-anxiolytic-like-behavior-by-retinoic-acid-in-zebrafish-involvement-of-oxidative-stress-and-antioxidant-defense-system
#11
Ratnalipi Mohanty, Saroj Kumar Das, Manorama Patri
Benzo[a]pyrene (B[a]P) is commonly associated with oxidative stress-induced neurotoxicity. Retinoic acid (RA) has been shown to exhibit neuroprotection in brain, and disruption of RA signaling via excess or deficient RA can lead to oxidative stress. B[a]P contamination in aquatic environment has been shown to lower the internal RA level. Thus, the present study was conducted in wild-type zebrafish to ameliorate the neurotoxic effect of B[a]P by waterborne RA co-supplementation. Findings showed that B[a]P induced anxiolytic-like behavioral response, and altered antioxidant activity in zebrafish is attenuated by RA...
January 6, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28061388/ancestral-benzo-a-pyrene-exposure-affects-bone-integrity-in-f3-adult-fish-oryzias-latipes
#12
Frauke Seemann, Chang-Bum Jeong, Ge Zhang, Miles Teng Wan, Baosheng Guo, Drew Ryan Peterson, Jae-Seong Lee, Doris Wai-Ting Au
Benzo[a]pyrene (BaP) at an environmentally relevant concentration (1μg/L) has previously been shown to affect bone development in a transgenerational manner in F3 medaka (Oryzias latipes) larvae (17dph). Here, we provide novel histomorphometric data demonstrating that the impaired bone formation at an early life stage is not recoverable and can result in a persistent transgenerational impairment of bone metabolism in F3 adult fish. A decrease in bone thickness and the occurrence of microcracks in ancestrally BaP-treated adult male fish (F3) were revealed by MicroCt measurement and histopathological analysis...
December 23, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28059605/fetal-dna-hypermethylation-in-tight-junction-pathway-is-associated-with-neural-tube-defects-a-genome-wide-dna-methylation-analysis
#13
Linlin Wang, Shanshan Lin, Ji Zhang, Tian Tian, Lei Jin, Aiguo Ren
Neural tube defects (NTDs) are a spectrum of severe congenital malformations of fusion failure of the neural tube during early embryogenesis. Evidence on aberrant DNA methylation in NTD development remains scarce, especially when exposure to environmental pollutant is taken into consideration. DNA methylation profiling was quantified using the Infinium HumanMethylation450 array in neural tissues from 10 NTD cases and 8 non-malformed controls (stage 1). Subsequent validation was performed using a Sequenom MassARRAY system in neural tissues from 20 NTD cases and 20 non-malformed controls (stage 2)...
January 6, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28049045/in-vitro-models-reveal-differences-in-the-developmental-neurotoxicity-of-an-environmental-polycylic-aromatic-hydrocarbon-mixture-compared-to-benzo-a-pyrene-neuronotypic-pc12-cells-and-embryonic-neural-stem-cells
#14
Theodore A Slotkin, Samantha Skavicus, Jennifer Card, Richard T Di Giulio, Frederic J Seidler
In addition to their carcinogenic activity, polycyclic aromatic hydrocarbons (PAHs) are suspected to be developmental neurotoxicants. We evaluated the effects of PAHs with two in vitro models that assess distinct "decision nodes" in neurodifferentiation: neuronotypic PC12 cells, which characterize the transition from cell replication to neurodifferentiation, neurite outgrowth and neurotransmitter specification; and embryonic neural stem cells (NSCs), which evaluate the origination of neurons and glia from precursors...
December 31, 2016: Toxicology
https://www.readbyqxmd.com/read/28044178/levels-and-sources-of-pahs-in-air-borne-pm2-5-of-hefei-city-china
#15
Ruoyu Hu, Guijian Liu, Hong Zhang, Huaqin Xue, Xin Wang
This work studied the concentrations and sources of polycyclic aromatic hydrocarbons (PAHs) in air-borne particulate matter of Hefei, China. Samples of PM2.5 were collected daily at two sites during May, 2014, and January, 2015. The average daily concentration of PM2.5 was 96.88 µg m(-3), which is higher than the 2012 China Ambient Air Quality Standard (GB3095-2012 24-h grade II) of 75 µg m(-3). The concentrations of 16 EPA priority polycyclic aromatic hydrocarbons (PAHs) were analyzed by gas chromatography-mass spectrometry...
January 2, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28043741/exposure-to-benzo-a-pyrene-impairs-decidualization-and-decidual-angiogenesis-in-mice-during-early-pregnancy
#16
Xueyan Li, Cha Shen, Xueqing Liu, Junlin He, Yubin Ding, Rufei Gao, Xinyi Mu, Yanqing Geng, Yingxiong Wang, Xuemei Chen
Benzo[a]pyrene (BaP) is a ubiquitous environmental persistent organic pollutant and a well-known endocrine disruptor. BaP exposure could alter the steroid balance in females. Endometrium decidualization and decidual angiogenesis are critical events for embryo implantation and pregnancy maintenance during early pregnancy and are modulated by steroids. However, the effect of BaP on decidualization is not clear. This study aimed to explore the effects of BaP on decidualization and decidual angiogenesis in pregnant mice...
December 30, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28040247/spermatozoa-a-relevant-biological-target-for-genotoxicity-assessment-of-contaminants-in-the-estuarine-bivalve-scrobicularia-plana
#17
Amélie Châtel, Mélanie Bruneau, Clémence Lièvre, Astrid Goupil, Catherine Mouneyrac
Evaluation of DNA quality of gametes is a relevant method to predict potential consequences of pollutants in the next generations, as it allows to define adverse outcome pathways implicated in pollutant-mediated toxicity for risk assessment. In the present study, a comet assay was developed for the spermatozoa of Scrobicularia plana exposed to 10 and 100μg/L of benzo[a]pyrene (B[a]P) for 24h and 5days. The induction of apoptosis and repair mechanisms was assessed by determining caspase-3 activity and polymerase cell nuclear antigen (PCNA) mRNA expression level...
December 28, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28035602/proteomic-characterization-of-the-outer-membrane-vesicle-of-the-halophilic-marine-bacterium-novosphingobium-pentaromativorans-us6-1
#18
Sung Ho Yun, Sang-Yeop Lee, Chi-Won Choi, Hayoung Lee, Hyun-Joo Ro, Sangmi Jun, Yong Min Kwon, Kae Kyoung Kwon, Sang-Jin Kim, Gun-Hwa Kim, Seung Il Kim
Novosphingobium pentaromativorans US6-1 is a Gram-negative halophilic marine bacterium able to utilize several polycyclic aromatic hydrocarbons such as phenanthrene, pyrene, and benzo[a]pyrene. In this study, using transmission electron microscopy, we confirmed that N. pentaromativorans US6-1 produces outer membrane vesicles (OMVs). N. pentaromativorans OMVs (hereafter OMVNovo) are spherical in shape, and the average diameter of OMVNovo is 25-70 nm. Proteomic analysis revealed that outer membrane proteins and periplasmic proteins of N...
January 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28032951/methanolic-bark-extract-of-acacia-catechu-ameliorates-benzo-a-pyrene-induced-lung-toxicity-by-abrogation-of-oxidative-stress-inflammation-and-apoptosis-in-mice
#19
Ayaz Shahid, Rashid Ali, Nemat Ali, Syed Kazim Hasan, Preeti Barnwal, Shekh Mohammad Afzal, Abul Vafa, Sarwat Sultana
Benzo(a)pyrene [B(a)P] is a well-known carcinogen present in the environment. In this study, we evaluated the protective potential of methanolic bark extract of Acacia catechu Willd. (MEBA) against the lung toxicity induced by B(a)P in Swiss albino mice. To determine the protective efficacy of MEBA, it was orally administered to the mice at two doses (200 and 400 mg/kg body weight) once daily for 7 days. Mice were also exposed (orally) to B(a)P at a dose of 125 mg/kg body weight on 7th day. Administration of B(a)P increased the activities of toxicity markers such as LDH, LPO, and XO with a subsequent decrease in the activities of tissue anti-oxidant armory (CAT, SOD, GST, GPx, GR, QR, and GSH)...
December 29, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/28025788/benzo-a-pyrene-degradation-and-microbial-community-responses-in-composted-soil
#20
Fengxiao Zhu, Sean Storey, Mardiana Mohd Ashaari, Nicholas Clipson, Evelyn Doyle
Benzo(a)pyrene degradation was compared in soil that was either composted, incubated at a constant temperature of 22 °C, or incubated under a temperature regime typical of a composting process. After 84 days, significantly more (61%) benzo(a)pyrene was removed from composted soil compared to soils incubated at a constant temperature (29%) or at composting temperatures (46%). Molecular fingerprinting approaches indicated that in composted soils, bacterial community changes were driven by both temperature and organic amendment, while fungal community changes were primarily driven by temperature...
December 26, 2016: Environmental Science and Pollution Research International
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