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Mao-Wen Weng, Hyun-Wook Lee, Sung-Hyun Park, Yu Hu, Hsing-Tsui Wang, Lung-Chi Chen, William N Rom, William C Huang, Herbert Lepor, Xue-Ru Wu, Chung S Yang, Moon-Shong Tang
Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human cancer agents. Many lines of evidence seriously question this conclusion. To resolve this issue, we determined DNA adducts induced by the three major TS carcinogens: benzo( a )pyrene (BP), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanoe (NNK), and aldehydes in humans and mice. In mice, TS induces abundant aldehyde-induced γ-hydroxy-propano-deoxyguanosine (γ-OH-PdG) and α-methyl-γ-OH-PdG adducts in the lung and bladder, but not in the heart and liver...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Reyna Cristina Colli-Dula, Xiefan Fang, David Moraga-Amador, Nacira Albornoz-Abud, Roberto Zamora-Bustillos, Ana Conesa, Omar Zapata-Perez, Diego Moreno, Emanuel Hernandez-Nuñez
Despite a wide number of toxicological studies that describe benzo[a]pyrene (BaP) effects, the metabolic mechanisms that underlie these effects in fish are largely unknown. Of great concern is the presence of BaP in aquatic systems, especially those in close proximity to human activity leading to consumption of potentially contaminated foods. BaP is a known carcinogen and it has been reported to have adverse effects on the survival, development and reproduction of fish. The purpose of this study was to investigate if a low dose of BaP can alter genes and key metabolic pathways in the liver and testis in male adult tilapia, and whether these could be associated with biological endpoints disruption...
June 8, 2018: Aquatic Toxicology
Samera H Hamad, Nathan M Johnson, Margaret E Tefft, Marielle C Brinkman, Sydney M Gordon, Pamela I Clark, Stephanie S Buehler
Objective: Our objective was to characterize physical properties and semivolatile harmful and potentially harmful constituent yields in the mainstream smoke (MSS) of 4 popular little cigars compared to the 3R4F reference cigarette. Methods: We used the ISO and Canadian Intense Regimen protocols to generate MSS for Cheyenne (Full Flavor and Menthol) and Swisher Sweets (Original and Sweet Cherry) little cigars; and the 3R4F. We examined physical properties such as length, tobacco filler mass, pressure drop, and ventilation for each product...
October 2017: Tobacco Regulatory Science
Rongyan Liu, Ruiwen He, Xinyi Cui, Lena Q Ma
Contaminants, such as polycyclic aromatic hydrocarbons (PAHs), can be absorbed on the particles of indoor dust, which may pose potential health risks. In this study, indoor dust samples were collected and sieved into 6 size fractions (i.e., <43 μm, 43-63 μm, 63-100 μm, 100-150 μm, 150-200 μm, and 200-2000 μm). Ingestion bioaccessibility of PAHs was measured by physiologically based extraction test. Bioaccessibility in fractions of 200-2000 μm was generally higher than those in other particle sizes...
May 28, 2018: Journal of Hazardous Materials
Evelyn Smit, Florian Caiment, Jolanda Piepers, Jos C S Kleinjans, Twan van den Beucken
Translational control is a cellular response mechanism which initiates adaptation during various stress situations. Here, we investigated the role of translational control after benzo[a]pyrene (BaP) exposure in primary mouse hepatocytes. Translated mRNAs were separated and captured based on the number of associated ribosomes using sucrose gradients and subjected to RNA sequencing (RNAseq) to investigate translational changes. Furthermore, unseparated RNA (total RNA) was used for RNAseq to determine the transcriptional alterations...
June 12, 2018: Toxicology Letters
Babajide O Ajayi, Isaac A Adedara, Olumide S Ajani, Matthew O Oyeyemi, Ebenezer O Farombi
BACKGROUND: The deterioration of male reproductive health may represent an outcome of an active disease and environmental factors. The present study investigated the modulatory role of [6]-gingerol in spermatotoxicity resulting from colitis and benzo[a]pyrene (B[a]P), an environmental and food-borne pollutant. METHODS: Group I (control) mice received corn oil alone, while group II ([6]-gingerol alone) mice orally received [6]-gingerol alone at 100 mg/kg body weight...
June 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Yidian Sun, Deming Dong, Liwen Zhang, Sinan He, Xiuyi Hua, Zhiyong Guo
The occurrence, spatial distribution, seasonal variation, sources, and ecological risks of polycyclic aromatic hydrocarbons (PAHs) in overlying water and surface sediments from Tiaozi River, which is an urban river running through the downtown of Siping City, a traditional industrial city of northeastern China, were investigated. The total PAH concentrations (ΣPAHs) in water varied from 473.5 to 2674.3 ng/L with a mean value of 1272.6 ng/L and ranged from 601.5 to 2906.3 ng/g with a mean value of 1534.4 ng/g in sediments...
June 14, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Pasquale Avino, Mauro Scungio, Luca Stabile, Gino Cortellessa, Giorgio Buonanno, Maurizio Manigrasso
Smoking activities still represent the main, and preventable, cause of lung cancer risk worldwide. For this reason, a number of studies were carried out to deepen and better characterize the emission of cigarette-generated mainstream aerosols in order to perform an a-priori evaluation of the particle doses and related lung cancer risks received by active smokers. On the contrary, a gap of knowledge still exists in evaluating the dose and risk received by passive smokers in indoor private micro-environments (e...
June 9, 2018: Science of the Total Environment
E Kudlek, M Dudziak
Organic micropollutants, in particular those of anthropogenic origin, may have a toxic influence on water organisms. Photochemical oxidation processes are one of the most effective methods of decomposition of a wide range of those compounds. During the oxidation process a large number of different by-products are generated, which can still be biologically active. The development of analytical techniques, including the reduction of the detection limit to several fg/L, allows the identification of even trace concentrations of compounds...
June 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Hao Chen, Xiaoping Diao, Hailong Zhou
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is well known for its teratogenic, mutagenic and carcinogenic effects. In this study, we applied metabolomics to investigate the tissue-specific metabolic responses of the Pinctada martensii digestive glands and gills after a short-duration exposure to BaP (1 μg/L and 10 μg/L). After 72 h of exposure to BaP, the majority of metabolite changes were related to osmolytes, energy metabolites, and amino acids. BaP (1 μg/L) accelerated energy deterioration and decreased osmotic regulation, while BaP (10 μg/L) disturbed energy metabolism and increased osmotic stress in the digestive glands...
June 2018: Marine Pollution Bulletin
Joseph Guevara-Luna, Patricia Alvarez-Fitz, Elvira Ríos-Leal, Macdiel Acevedo-Quiroz, Sergio Encarnación-Guevara, Ma Elena Moreno-Godinez, Mildred Castellanos-Escamilla, Jeiry Toribio-Jiménez, Yanet Romero-Ramírez
Benzo[a]pyrene (BaP) is recognized as a potentially carcinogenic and mutagenic hydrocarbon, and thus, its removal from the environment is a priority. The use of thermophilic bacteria capable of biodegrading or biotransforming this compound to less toxic forms has been explored in recent decades, since it provides advantages compared to mesophilic organisms. This study assessed the biotransformation of BaP by the thermophilic bacterium Bacillus licheniformis M2-7. Our analysis of the biotransformation process mediated by strain M2-7 on BaP shows that it begins during the first 3 h of culture...
June 9, 2018: World Journal of Microbiology & Biotechnology
Biljana D Škrbić, Kiwao Kadokami, Igor Antić
This study demonstrates the occurrence of 940 organic micro-pollutants in surface water of four rivers, one irrigation canal system, and two lakes in Vojvodina Province, the northern part of Serbia, summing in total eighteen samples. The number of detected chemicals ranged from 22 to 84, with 127 micro-pollutants detected at least once, representing 13% of the studied substances. The targeted compounds include n-alkanes, sterols, polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides polychlorinated biphenyls, pesticides, pharmaceutical active compounds, industrial chemicals, plasticizers, etc...
June 7, 2018: Environmental Research
Ran Han, Huiping Dai, Chuanjie Yang, Shuhe Wei, Lei Xu, Wei Yang, Xuekai Dou
The role of same amendment on phytoremediating different level contaminated soils is seldom known. Soil pot culture experiment was used to compare the strengthening roles of cysteine (CY), EDTA, salicylic acid (Sa), and Tween 80 (TW) on hyperaccumulator Solanum nigrum L. phytoremediating higher level of single cadmium (Cd) or Benzo(a)pyrene (BAP) and their co-contaminated soils. Results showed that the Cd capacities (ug pot-1 ) in shoots of S. nigrum in the combined treatment T0.1EDTA+0.9CY were the highest for the 5 and 15 mg kg-1 Cd contaminated soils...
July 29, 2018: International Journal of Phytoremediation
Arash Etemadi, Christian C Abnet, Barry I Graubard, Laura Beane- Freeman, Neal D Freedman, Linda Liao, Sanford M Dawsey, Rashmi Sinha
Distal and proximal colon tumors have distinct incidence trends and embryonic origins; whether these sub-sites have distinct susceptibilities to known risk factors is unclear. We used pooled data from 407,270 participants in three US-based studies, with overall median follow-up of 13.8 years. We used adjusted Cox models to analyze the association between dietary intakes (from diet history questionnaire) of total, processed and unprocessed red meat; total white meat, poultry and fish; and meat-related compounds: heme iron, nitrate, nitrite, the heterocyclic amines (HCAs), and benzo(a)pyrene (B(a)P) and incidence of colorectal cancer subsites...
June 6, 2018: International Journal of Cancer. Journal International du Cancer
Ainhoa Rubio-Clemente, Edwin Chica, Gustavo Peñuela
The presence of polycyclic aromatic hydrocarbons, such as anthracene (AN) and benzo[a]pyrene (BaP), in water has become a problem of great concern due to the detrimental health effects caused to humans and living beings. In this work, the efficiency of the UV/H2 O2 system for degrading the target compounds at ultra-trace levels in surface water has been evaluated. For this purpose, a previous optimization step using a face-centered central composite experimental design has been conducted, considering the effect of the UV-C irradiance and the initial concentration of H2 O2 ...
June 5, 2018: Environmental Science and Pollution Research International
Chanokporn Muangchinda, Adisan Rungsihiranrut, Pinidphon Prombutara, Suwat Soonglerdsongpha, Onruthai Pinyakong
A bacterial consortium, named SWO, was enriched from crude oil-contaminated seawater from Phrao Bay in Rayong Province, Thailand, after a large oil spill in 2013. The bacterial consortium degraded a polycyclic aromatic hydrocarbon (PAH) mixture consisting of phenanthrene, anthracene, fluoranthene, and pyrene (50 mg L-1 each) by approximately 73%, 69%, 52%, and 48%, respectively, within 21 days. This consortium exhibited excellent adaptation to a wide range of environmental conditions. It could degrade a mixture of four PAHs under a range of pH values (4...
May 29, 2018: Journal of Hazardous Materials
Jan Skála, Radim Vácha, Pavel Čupr
The main topic of this study is a human health risk assessment of a defined exposure scenario in the floodplain soils of the headwater areas of the central European watershed, with the aim of exploring both multivariate and regional data structures. Flood-prone areas are recognized worldwide to be susceptible to contamination and its redistribution. Contributions of various classes of toxic compounds (organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs)) to human health risks were assessed in a screening risk assessment...
June 1, 2018: International Journal of Environmental Research and Public Health
Jae Hac Ko, Jingchen Wang, Qiyong Xu
Polycyclic aromatic hydrocarbons (PAHs) not only present a risk to human health when released into the air, but also can be precursors to form particulate matter (PM) during sewage sludge pyrolysis. In this study, 16 EPA PAHs in PM (ΣPAHPM ) during sewage sludge pyrolysis were investigated with increasing temperature (200o C-1000 °C) and holding time under different operation conditions [inert gas flow rate (IGFR) (200-800 mL/min) and heating rate (5-20 °C/min)]. ΣPAHPM varied with temperature, IGFR, and heating rate, and ranged from 597 (±41) μg/g to 3240 (±868) μg/g...
May 21, 2018: Chemosphere
Pasano Bojang, Kenneth S Ramos
Long Interspersed Nuclear Element-1 (LINE-1 or L1) reactivation is linked to poor prognosis in Non-Small Cell Lung Carcinoma (NSCLC), but the molecular bases of this response remain largely unknown. In this report, we show that challenge of human bronchial epithelial cells (HBECs) with the lung carcinogen, benzo(a)pyrene (BaP), shifted the L1 promoter from a heterochromatic to euchromatic state through disassembly of the Nucleosomal and Remodeling Deacetylase (NuRD) complex. Carcinogen challenge was also associated with partial displacement of constituent proteins from the nuclear to the cytoplasmic compartment...
May 30, 2018: Molecular Oncology
Caroline Santos, Marcelo Tempesta de Oliveira, Ilce Mara de Syllos Cólus, Silvia Helena Sofia, Claudia Bueno Dos Reis Martinez
The goal of this work was to design specific cyp1a primers for the fish Prochilodus lineatus to study the expression of this gene and its relation to the activity of biotransformation phase I enzyme (ethoxyresorufin O-deethylase - EROD) and genotoxic damage after 6 and 24 h of benzo(a)pyrene (B(a)P) intraperitoneal injection. In comparison to fish injected only with canola oil (vehicle), the expression of cyp1a and EROD activity both in the liver and gills were significantly higher after 6 and 24 h of B(a)P injection...
May 21, 2018: Environmental Toxicology and Pharmacology
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