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Benzo(a)pyrene

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https://www.readbyqxmd.com/read/29051449/do-16-polycyclic-aromatic-hydrocarbons-represent-pah-air-toxicity
#1
Vera Samburova, Barbara Zielinska, Andrey Khlystov
Estimation of carcinogenic potency based on analysis of 16 polycyclic aromatic hydrocarbons (PAHs) ranked by U.S. Environmental Protection Agency (EPA) is the most popular approach within scientific and environmental air quality management communities. The majority of PAH monitoring projects have been focused on particle-bound PAHs, ignoring the contribution of gas-phase PAHs to the toxicity of PAH mixtures in air samples. In this study, we analyzed the results of 13 projects in which 88 PAHs in both gas and particle phases were collected from different sources (biomass burning, mining operation, and vehicle emissions), as well as in urban air...
August 15, 2017: Toxics
https://www.readbyqxmd.com/read/29048840/-determination-of-four-polycyclic-aromatic-hydrocarbons-in-olive-oil-by-high-performance-liquid-chromatography-fluorescent-detection
#2
Jiaying Zhao, Xiaomin Li, Xiaohua Lu, Qinghe Zhang, Weibing Zhang
A method for the determination of four polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]anthracene, chrysene, benzo[b]fluoranthene and benzo[a]pyrene in olive oil by high performance liquid chromatography-fluorescent detection (HPLC-FLD) was developed. The olive oil samples were diluted with isopropanol and cleaned-up by a solid phase extraction cartridge with π-π specificity. Critical isomers were separated by gradient elution with water-acetonitrile on an Agilent ZORBAX Eclipse PAH column (100 mm×2...
July 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048810/-simultaneous-determination-of-15-polycyclic-aromatic-hydrocarbons-in-cigarette-filter-by-gas-chromatography-tandem-mass-spectrometry
#3
Xiaotao Zhang, Li Zhang, Yibin Ruan, Weiwei Wang, Houwei Ji, Qiang Wan, Fucheng Lin, Jian Liu
A method for the simultaneous determination of 15 polycyclic aromatic hydrocarbons in cigarette filter was developed by isotope internal standard combined with gas chromatography-tandem mass spectrometry. The cigarette filters were extracted with dichloromethane, and the extract was filtered with 0.22 μm organic phase membrane. The samples were isolated by DB-5MS column (30 m×0.25 mm, 0.25 μm) and detected using multiple reaction monitoring mode of electron impact source under positive ion mode. The linearities of the 15 polycyclic aromatic hydrocarbons (acenapthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, ben[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenzo[a,h]anthracene, benzo[g,h,i]perylene and indeno[1,2,3-c,d]pyrene) were good, and the correlation coefficients (R(2)) ranged from 0...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048787/-rapid-determination-of-benzo-a-pyrene-in-foods-by-ultra-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry-with-atmospheric-pressure-chemical-ionization
#4
Xiaoyi Zhang, Xiuyao Zhang, Xinxin Cai, Ruifen Li
A method for the determination of benzo[a]pyrene in foods was developed by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) based on isotope dilution and molecularly imprinted solid-phase extraction (MIP-SPE). The target analyte in samples was extracted with n-hexane after spiked with benzo[a]pyrene-d12, and purified using MIP-SPE to eliminate most of the coextracts. The separation of benzo[a]pyrene was carried out on an XBridge BEH C18 column with gradient elution of methanol and water...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29042535/mechanism-of-error-free-replication-across-benzo-a-pyrene-stereoisomers-by-rev1-dna-polymerase
#5
Olga Rechkoblit, Alexander Kolbanovskiy, Hannah Landes, Nicholas E Geacintov, Aneel K Aggarwal
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG adducts. Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed mechanism of DNA synthesis opposite undamaged and damaged guanine. Here we report high-resolution structures of yeast Rev1 with three BP-N (2)-dG adducts, namely the 10S (+)-trans-BP-N (2)-dG, 10R (+)-cis-BP-N (2)-dG, and 10S ( - )-cis-BP-N (2)-dG...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29035147/isolation-production-and-characterization-of-a-new-single-chain-anti-idiotypic-antibody-against-benzo-a-pyrene
#6
K V Arnst, A E Studennikov, V A Ustinov, A N Glushkov
Polycyclic aromatic hydrocarbons are chemical carcinogens which could induce the development of human cancers. Anti-idiotypic antibodies against benzo[a]pyrene are perspective for human cancer immunoprophylaxis and tumor immunodiagnostic. The purpose of this study was isolating of anti-idiotypic antibodies against benzo[a]pyrene from human lymphocytes naïve phage library. The anti-idiotypic antibody, named B5, was selected. Analysis of the nucleotide and amino acid sequences B5 showed no similarity to known protein databases antibodies...
October 16, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29032809/evaluation-of-polycyclic-aromatic-hydrocarbons-bioavailability-on-santos-bay-brazil-through-levels-of-biliary-metabolites
#7
Ana Cecília Rizzatti de Albergaria-Barbosa, Denis Albuquerque Moreira da Silva, Arthur José da Silva Rocha, Satie Taniguchi, Vinicius Faria Patire, June Ferraz Dias, Wellington Silva Fernandez, Marcia Caruso Bícego
This study evaluated the PAH bioavailability from Santos Bay (Brazil) in 4 species of fish, using PAH biliary metabolites. The collection was done monthly, between July and December, in three different regions of Santos Bay. The metabolites were analyzed through a high performance liquid chromatograph with fluorescence detectors. Total metabolites concentrations ranged from 65.5 to 589μgg(-1) of bile, evidencing PAH bioavailability on Santos Bay. Levels of phenanthrene and benzo[a]pyrene metabolites were in the classification range of areas moderate contaminated...
October 10, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29032526/micro-pollutants-in-sediment-samples-in-the-middle-danube-region-serbia-occurrence-and-risk-assessment
#8
Biljana D Škrbić, Kiwao Kadokami, Igor Antić, Grigorije Jovanović
This is the first comprehensive study on the occurrence of 940 semi-volatile organic compounds including sterols, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), pesticides, plasticizers, and other emerging compounds in 10 river and canal sediments collected in northern Serbia. For quantification of investigated compounds GC-MS-MS (selected reaction monitoring) and GC-MS (using both selected ion monitoring and total ion monitoring) methods were used. The number of detected compounds was in the range of 85-117, while the sum of the concentrations varied from 959 μg/kg dry-wt to 84,445 μg/kg dry-wt...
October 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29032469/itraq-based-proteomic-profiling-of-a-microbacterium-sp-strain-during-benzo-a-pyrene-removal-under-anaerobic-conditions
#9
Junfeng Dou, Wei Qin, Aizhong Ding, Xiang Liu, Yi Zhu
This study focused on the protein expression of a Microbacterium sp. strain that utilized various concentrations of benzo(a)pyrene (BaP) as the sole source of carbon and energy under anaerobic conditions. A total of 1539 protein species were quantified by isobaric tags for relative and absolute quantitation (iTRAQ) coupled with LC-MS/MS. GO, COG, and pathway enrichment analysis showed that most proteins demonstrated catalytic and binding functions and were mainly involved in metabolic processes, cellular processes, and single-organism processes...
October 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29022178/interactive-effects-of-pahs-with-different-rings-and-as-on-their-uptake-transportation-and-localization-in-as-hyperaccumulator
#10
Xiaoyong Liao, Zeying Wu, Xu Ma, Xuegang Gong, Xiulan Yan
In order to illuminate the mechanism of the interaction of polycyclic aromatic hydrocarbon (PAH) with different benzene rings and arsenic (As) in As hyperaccumulator, Pteris vittata L., the uptakes of PAHs were investigated using hydroponics simulation and localizations of PAHs in the plant were determined using two-photon laser scanning confocal microscopy (TPLSCM). The results showed that the total As concentration in different parts of P. vittata decreased in the presence of PAHs with increased numbers of benzene rings: 38...
October 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29019276/benzo-a-pyrene-induces-lung-toxicity-and-inflammation-in-mice-prevention-by-carvacrol
#11
P Barnwal, A Vafa, S M Afzal, A Shahid, S K Hasan, Alpashree, S Sultana
Benzo(a)pyrene (B(a)P) is an environmental pollutant which causes various lung toxicities. The present study was designed to evaluate the protective effects of carvacrol, a monoterpenic phenol against B(a)P-induced lung toxicity. In this study, Swiss albino mice were pretreated with carvacrol (25 mg/kg and 50 mg/kg) orally for 7 consecutive days before administering oral B(a)P (125 mg/kg). Preventive efficacy of carvacrol was assessed in terms of membrane oxidation, antioxidant enzyme activities, histopathological changes, and inflammatory (iNOS, NF-κB, and COX-2) markers...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28990778/benzo-a-pyrene-induces-autophagic-and-pyroptotic-death-simultaneously-in-hl-7702-human-normal-liver-cells
#12
Li Yuan, Junyi Liu, Hong Deng, Chunxia Gao
As a common polycyclic aromatic hydrocarbon compound, benzo(α)pyrene (BaP) is readily produced in processing of oil and fatty foods. It is not only a strong carcinogen, but also a substance with strong immunotoxicity and reproduction toxicity. Autophagy and pyroptosis are two types of programmed cell death. Whether or not BaP damages body tissues via autophagy or pyroptosis remains unknown. The present study investigated the effects of BaP on autophagy and pyroptosis in HL-7702 cells. The results showed that BaP induced cell death in HL-7702 cells, enhanced the intracellular levels of ROS, arrested cell cycle at the S phase...
October 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28987621/combined-intervention-of-static-magnetic-field-and-growth-rate-of-microbacterium-maritypicum-cb7-for-benzo-a-pyrene-biodegradation
#13
Ahlem Mansouri, Chiraz Abbes, Ahmed Landoulsi
In this work, we have shown for the first time that Microbacterium maritypicum CB7 bacterium is capable to use Benzo(a)Pyrene as a sole source of carbon and energy. We followed the growth kinetics of M. maritypicum CB7 in minimum medium supplemented with 10 mg/l Benzo(a)Pyrene for 30 days. The results obtained showed that M. maritypicum CB7 strain is able to degrade 69% of the initial amount of BaP. In order to improve the rate of biodegradation, we tested for 5 days the effect of a static magnetic field (SMF) at different inductions (50, 100 and 200 mT) on the degradation kinetics of Benzo(a)Pyrene by M...
October 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28987381/altered-gene-expression-profiles-in-the-lungs-of-benzo-a-pyrene-exposed-mice-in-the-presence-of-lipopolysaccharide-induced-pulmonary-inflammation
#14
Q Shi, R R Fijten, D Spina, Y Riffo Vasquez, V M Arlt, R W Godschalk, F J Van Schooten
Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5mg/mouse) by intratracheal instillation. Gene expression changes were analyzed in mouse lungs by RNA microarrays. Analysis of genes that are known to be involved in the cellular response to B[a]P indicated that LPS significantly inhibited gene expression of various enzymes linked to B[a]P metabolism, which was confirmed by phenotypic analyses of enzyme activity...
October 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28986083/the-effect-of-sewage-sludge-fertilization-on-the-concentration-of-pahs-in-urban-soils
#15
Elżbieta Wołejko, Urszula Wydro, Agata Jabłońska-Trypuć, Andrzej Butarewicz, Tadeusz Łoboda
This paper analyses sources of sixteen PAHs - polycyclic aromatic hydrocarbons in urbanized areas by using selected diagnostic ratios. Simultaneously, an attempt was made to determine how sewage sludge changes PAHs content in urbanized areas soils. In the experiment three lawns along the main roads in Bialystok with different traffic intensity, three doses of sewage sludge and two years of study were considered. There was no effect of fertilization with sewage sludge on the sum of 16 PAHs in urban soil samples, nevertheless, the sum of 16 PAHs was reduced from 2...
October 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28985597/human-health-risk-assessment-of-ground-water-contaminated-with-petroleum-pahs-using-monte-carlo-simulations-a-case-study-of-an-indian-metropolitan-city
#16
Bokam Rajasekhar, Indumathi M Nambi, Suresh Kumar Govindarajan
Underground pipelines are frequently used to transport petroleum fuels, through industrial as well as residential zones. Chennai is one of the four largest metropolitan cities of India. The region of interest in this study is located in the northern part of the Chennai. Ground water of this area was contaminated with polyaromatic hydrocarbons (PAHs) from the leaking oil storage tanks and pipe lines. Health risk assessment was conducted for exposure to PAHs in the ground water using incremental life time cancer risk (ILCR) models coupled with benzo[a]pyrene toxic equivalent method...
October 3, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28985535/evaluation-of-polyurethane-foam-passive-air-sampler-puf-as-a-tool-for-occupational-pah-measurements
#17
Bo Strandberg, Anneli Julander, Mattias Sjöström, Marie Lewné, Hatice Koca Akdeva, Carolina Bigert
Routine monitoring of workplace exposure to polycyclic aromatic hydrocarbons (PAHs) is performed mainly via active sampling. However, active samplers have several drawbacks and, in some cases, may even be unusable. Polyurethane foam (PUF) as personal passive air samplers constitute good alternatives for PAH monitoring in occupational air (8 h). However, PUFs must be further tested to reliably yield detectable levels of PAHs in short exposure times (1-3 h) and under extreme occupational conditions. Therefore, we compared the personal exposure monitoring performance of a passive PUF sampler with that of an active air sampler and determined the corresponding uptake rates (Rs)...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28972195/exposure-to-genotoxic-compounds-alters-in-vitro-cellular-voc-excretion
#18
Rianne Fijten, Agnieszka Smolinska, Quan Shi, Daniëlle Pachen, Jan Dallinga, Agnes Boots, Frederik Jan van Schooten
Genotoxic carcinogens significantly damage cells and tissues by targeting macromolecules such as proteins and DNA, but their mechanisms of action and effects on human health are diverse. Consequently, determining the amount of exposure to a carcinogen and its cellular effects is essential, yet difficult. The aim of this manuscript was to investigate the potential of detecting alterations in Volatile Organic Compounds (VOCs) profiles in the in vitro headspace of pulmonary cells after exposure to the genotoxic carcinogens cisplatin and benzo[a]pyrene using two different sampling set-ups...
October 3, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28965195/variation-in-foliar-uptake-of-polycyclic-aromatic-hydrocarbons-in-six-varieties-of-winter-wheat
#19
Taoran Shi, Kai Tian, Huanyu Bao, Xueping Liu, Fuyong Wu
To investigate intraspecific variations of foliar uptake of polycyclic aromatic hydrocarbons (PAHs) of winter wheat (Triticum aestivum L.), leaves of six varieties including Changwu 521 (CW), Hedong TX-006 (HD), Jiaomai 266 (JM), Xiaoyan 22 (XY), Yunong 949 (YN), and Zhongmai 175 (ZM) were exposed to three levels of (0, 0.25, and 1.5 mg L(-1)) mixture of six selected PAHs (phenanthrene, anthracene, pyrene, benz[a]anthracene, benzo[a]pyrene, and benzo[g,h,i]perylene). After 10 consecutive days of application, all the six selected PAHs (Σ6 PAHs) were determined in the leaves of the six varieties of the winter wheat...
September 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28959625/human-health-risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-smoked-fish-species-from-markets-in-southern-nigeria
#20
Isioma Tongo, Ozekeke Ogbeide, Lawrence Ezemonye
Polycyclic Aromatic Hydrocarbons (PAHs) levels in four commonly consumed smoked fish species from markets in Southern Nigeria were assessed to evaluate possible human health risks associated with consumption. Varying levels of PAH congeners were observed in the fish tissues with the highest total concentration of PAHs in Scomber scombrus. High concentrations of benzo(a)pyrene was observed in Clarias gariepinus and Ethmalosa fimbriata with values above the guideline value of 0.05 mg/kg. The Dietary Daily Intake (DDI) value for total PAHs (∑PAHs) was highest for S...
2017: Toxicology Reports
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