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https://www.readbyqxmd.com/read/29679899/postpartum-posttraumatic-and-acute-stress-in-mothers-and-fathers-of-infants-with-very-low-birth-weight-cross-sectional-results-from-a-controlled-multicenter-cohort-study
#1
Nadine Helle, Claus Barkmann, Stephan Ehrhardt, Carola Bindt
BACKGROUND: The birth of a preterm infant can be stressful and traumatic for parents and may cause posttraumatic stress symptoms and disorders. There is a dearth of data from controlled studies regarding level, prevalence, risk, and predictors of these symptoms in parents after preterm birth. METHODS: As part of the longitudinal HaFEn-study, data from parents of infants with very low birth weight (VLBW), and term infants were cross-sectionally analyzed. We recruited parents at the three largest perinatal care centers in Hamburg, Germany...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679898/heart-rate-variability-alterations-in-late-life-depression-a-meta-analysis
#2
REVIEW
Lydia Brown, Chandan Karmakar, Richard Gray, Ripu Jindal, Terrence Lim, Christina Bryant
OBJECTIVE: There is strong evidence for a bi-directional relationship between heart-health and depression in later life, but the physiological mechanisms underlying this relationship remain unclear. Heart rate variability is one promising factor that might help explain this relationship. We present results of a meta-analysis that considers heart rate variability alterations in older adults with depression. METHODS: Literature search of Embase, PsychInfo and Medline revealed five clinical studies and six observational studies that examined the relationship between heart rate variability and depression in adults with a mean age over 60...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679896/treatment-as-usual-tau-as-a-control-condition-in-trials-of-cognitive-behavioural-based-psychotherapy-for-self-harm-impact-of-content-and-quality-on-outcomes-in-a-systematic-review
#3
REVIEW
Katrina Witt, Daniela Pache de Moraes, Tatiana Taylor Salisbury, Ella Aren S Man, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen, Keith Hawton
BACKGROUND: Randomized controlled trials (RCTs) are the mainstay of evaluations of the efficacy of psychosocial interventions. In a recent Cochrane systematic review we analysed the efficacy of cognitive behavioural-based psychotherapies compared to treatment as usual (TAU) in adults who self-harm. In this study we examine the content and reporting quality of TAU in these trials and their relationship to outcomes. METHODS: Five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, EMBASE, and PsycINFO) were searched for RCTs, indexed between 1 January 1998 and 30 April 2015, of cognitive-behavioural interventions compared to TAU for adults following a recent (within six months) episode of self-harm...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#4
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679809/colonic-ischemia-mimicking-obstruction-due-to-sigmoid-colon-cancer-a-case-report
#5
Jiro Kimura, Alan Kawarai Lefor, Tadao Kubota
INTRODUCTION: Colonic ischemia is challenging to diagnose preoperatively. We present a patient with colonic ischemia, initially considered to have colonic obstruction. We review the history, physical findings, imaging, operative documents and postoperative diagnosis of this patient with an atypical presentation of colonic ischemia. PRESENTATION OF CASE: A 74-year old female presented with dyspnea on exertion and melena. A tumor in the sigmoid colon was identified by colonoscopy and biopsy showed adenocarcinoma...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29679782/outcomes-after-off-label-use-of-the-pipeline-embolization-device-for-intracranial-aneurysms-a-multicenter-cohort-study
#6
S G Zammar, T J Buell, C J Chen, R W Crowley, D Ding, C J Griessenauer, B L Hoh, K C Liu, C S Ogilvy, Raper, A Singla, A J Thomas, K M Cockroft, S D Simon
OBJECTIVES: The aim of this retrospective multicenter cohort study is to examine the outcomes of the Pipeline embolization device (PED) for the treatment of intracranial aneurysms outside of United States Food and Drug Administration approved (off-label) indications. METHODS: Data from aneurysm patients treated with the PED for off-label indications was pooled from four different centers. The primary endpoints were decline in modified Rankin Scale (mRS) by at least 1 point and angiographic aneurysm occlusion at follow-up...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29679731/changes-in-pediatric-dxa-measures-of-musculoskeletal-outcomes-and-correlation-with-quantitative-ct-following-treatment-of-acute-lymphoblastic-leukemia
#7
Sogol Mostoufi-Moab, Andrea Kelly, Jonathan A Mitchell, Joshua Baker, Babette S Zemel, Jill Brodsky, Jin Long, Mary B Leonard
We previously reported significant gains in pQCT measures of tibia trabecular bone mineral density (BMD) and cortical structure following completion of therapy in children and adolescents with acute lymphoblastic leukemia (ALL). The objective of this study was to examine changes in DXA measures used in clinical practice and expressed as Z-scores using robust national reference data. Children and adolescents, ages 5 to 18 years were enrolled within 2 (median 0.8) years of completing ALL therapy. DXA total-body less-head bone mineral content (TBLH-BMC), and spine, total hip, femoral neck, and 1/3rd radius areal BMD (aBMD) were assessed in 45 participants at enrollment and 12-months later...
April 18, 2018: Bone
https://www.readbyqxmd.com/read/29679728/magnetic-resonance-imaging-of-the-lumbar-spine-determining-clinical-impact-and-potential-harm-from-overuse
#8
Nathan M Wnuk, Tarik K Alkasab, Daniel I Rosenthal
BACKGROUND: Lumbar spine MRI is frequently said to be "overused" in the evaluation of low-back pain, yet data concerning the extent of overuse and on potential harmful effects are lacking. PURPOSE: To determine the proportion of examinations with a detectable impact on patient care (actionable outcomes). STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: 5,365 outpatient lumbar spine MR examinations OUTCOME MEASURES: Actionable outcomes included: 1) findings leading to an intervention making use of anatomical information such as surgery; 2) new diagnoses of cancer, infection, or fracture; or 3) following known lumbar spine pathology...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679725/achyranthis-bidentatae-radix-enhanced-articular-distribution-and-anti-inflammatory-effect-of-berberine-in-sanmiao-wan-using-an-acute-gouty-arthritis-rat-model
#9
Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679690/reduced-body-weight-or-increased-muscle-quality-which-is-more-important-for-improving-physical-function-following-exercise-and-weight-loss-in-overweight-and-obese-older-women
#10
Chad R Straight, Alison C Berg, Rachelle A Reed, Mary Ann Johnson, Ellen M Evans
The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4 kg/m2 ) older (age = 69.3 ± 4.1 y) women completed 6 months of multicomponent exercise (cardiorespiratory, resistance, balance and flexibility training) and weight loss (hypocaloric diet that reduced energy intake by ~500 kcal/d)...
April 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29679681/inhibition-of-protein-kinase-a-and-girk-channel-reverses-fentanyl-induced-respiratory-depression
#11
Xiaonan Liang, Zheng Yong, Ruibin Su
Opioid-induced respiratory depression is a major obstacle to improving the clinical management of moderate to severe chronic pain. Opioids inhibit neuronal activity via various pathways, including calcium channels, adenylyl cyclase, and potassium channels. Currently, the underlying molecular pathway of opioid-induced respiratory depression is only partially understood. This study aimed to investigate the mechanisms of opioid-induced respiratory depression in vivo by examining the effects of different pharmacological agents on fentanyl-induced respiratory depression...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29679656/pd-1-blocks-lytic-granule-polarization-with-concomitant-impairment-of-integrin-outside-in-signaling-in-natural-killer-cell-immunological-synapse
#12
Yu Huang, Zhiying Chen, Joon Hee Jang, Mirza S Baig, Grant Bertolet, Casey Schroeder, Shengjian Huang, Qian Hu, Yong Zhao, Dorothy E Lewis, Lidong Qin, Michael Xi Zhu, Dongfang Liu
BACKGROUND: Inhibitory receptor programmed cell death protein-1 (PD-1) is upregulated on a variety of immune cells, including natural killer (NK) cells, during chronic virus infection and tumorigenesis. Blockade of PD-1 or its ligands produces durable clinical responses with tolerable side effects in patients with a broad spectrum of cancers. However, the underlying molecular mechanisms of how PD-1 regulates NK cell function remain poorly characterized. OBJECTIVE: We sought to determine what effect PD-1 signaling has on NK cells...
April 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29679620/longitudinal-association-between-periodontitis-and-development-of-diabetes-running-title-periodontitis-and-diabetes-development
#13
Kaumudi J Joshipura, Francisco J Muñoz-Torres, Bruce A Dye, Brian G Leroux, Margarita Ramírez-Vick, Cynthia M Pérez
BACKGROUND: Clinical trials have shown very modest short-term improvements in glycemic control among participants with diabetes after periodontitis treatment. Few longitudinal studies suggest that periodontitis may be related to prediabetes/diabetes risk. METHODS: We evaluated 1,206 diabetes free participants in the San Juan Overweight Adults Longitudinal Study (SOALS) and 941 with complete 3-year follow-up data were included. The National Health and Nutrition Examination Survey (NHANES) methods were used to assess periodontitis...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679616/early-detection-of-diabetic-retinopathy
#14
REVIEW
Hamid Safi, Sare Safi, Ali Hafezi-Moghadam, Hamid Ahmadieh
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that progresses before the first clinical signs of DR appear. Reduction of the inner neuroretinal layer thickness on macular optical coherence tomography (OCT), reduced contrast sensitivity primarily at low spatial frequencies, abnormal results in color vision and microperimetry tests, and a prolonged implicit time recorded by multifocal electroretinography have been proposed for detection of early functional and nonvisible structural neuroretinal changes...
April 18, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679592/multiple-coagulation-factor-deficiency-protein-2-as-a-crucial-component-in-metastasis-of-human-oral-cancer
#15
Megumi Fukamachi, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Kazuaki Fushimi, Hiroki Kasama, Manabu Iyoda, Yasuyuki Minakawa, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Multiple coagulation factor deficiency protein 2 (MCFD2), a binding partner of lectin mannose binding 1 (LMAN1), causes combined deficiencies of coagulation factors V and VIII. MCFD2 function in inherited hematologic disorders is well elucidated; however, little is known about its role in human tumorigenesis. The aim of the current study was to investigate the states of MCFD2 in oral squamous cell carcinoma (OSCC). The expression of MCFD2 was up-regulated significantly in all cell lines examined. Evaluation of the cellular functions associated with tumoral metastasis showed that MCFD2 knockdown (shMCFD2) cells exhibited significantly lower cellular invasiveness and migration and higher cellular adhesion compared with shControl cells...
April 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29679493/ppars-and-pain
#16
REVIEW
Bright N Okine, Jessica C Gaspar, David P Finn
Chronic pain is a common cause of disability worldwide and remains a global health and socioeconomic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain, or associated with significant adverse side effects. The peroxisome proliferator-activated receptors (PPARs), a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679487/allergen-specific-immunotherapy-induces-regulatory-t-cells-in-an-atopic-dermatitis-mouse-model
#17
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
https://www.readbyqxmd.com/read/29679433/students-attitudes-to-suicide-and-suicidal-persons-a-cross-national-and-cultural-comparison-between-turkey-and-united-kingdom
#18
Chris Flood, Mualla Yilmaz, Louise Phillips, Tracy Lindsay, Mehmet Eskin, Janet Hiley, Bahar Tasdelen
INTRODUCTION: Suicide is a major public health issue internationally and the impact of positive or negative attitudes amongst the mental health professional workforce warrants scrutiny. The study aimed to examine English and Turkish nursing students' attitudes towards people with suicidal behaviour. METHOD: This cross-cultural study reports on attitudes of 240 nursing students towards suicide in Turkey and 82 nursing students in the UK. A reliable and valid twenty-four item 'Attitudes towards Suicide Scale' and 'Social Reactions to Suicidal Persons Scale' were used to measure attitudes...
April 21, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29679412/influence-of-the-medication-environment-on-the-unsafe-medication-behavior-of-nurses-a-path-analysis
#19
Xi Yu, Ce Li, Xueqin Gao, Furong Liu, Ping Lin
AIMS AND OBJECTIVES: To explore the relationship between the medication environment and the unsafe medication behavior of nurses and to analyze its influence path. BACKGROUND: Unsafe medication behavior is the direct cause of medication error. The organizational environment is the foundation of and plays a guiding role in work behavior. Whether the medication environment correlates with the unsafe medication behavior of nurses remains unclear. DESIGN: This study used a correlative design with self-administered questionnaires, and the SHEL model, an acronym of its elements of software, hardware, environment, and liveware, was used as the framework for the medication environment...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679378/prominent-microglial-activation-in-cortical-white-matter-is-selectively-associated-with-cortical-atrophy-in-primary-progressive-aphasia
#20
Daniel T Ohm, Garam Kim, Tamar Gefen, Alfred Rademaker, Sandra Weintraub, Eileen Bigio, M-Marsel Mesulam, Emily Rogalski, Changiz Geula
AIMS: Primary progressive aphasia (PPA) is a clinical syndrome characterized by selective language impairments associated with focal cortical atrophy favouring the language dominant hemisphere. PPA is associated with Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and significant accumulation of activated microglia. Activated microglia can initiate an inflammatory cascade that may contribute to neurodegeneration, but their quantitative distribution in cortical white matter and their relationship with cortical atrophy are unknown...
April 21, 2018: Neuropathology and Applied Neurobiology
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