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https://www.readbyqxmd.com/read/28645124/-paralytic-ileus-with-fatal-consequence-under-psychotropic%C3%A2-medication
#1
Ingo Runte, Ulrich Hamberger
In the area of Bielefeld there occurred a striking accumulation of four cases of death as a consequence of a paralytic ileus within a period of two years. All four patients suffered from a psychotic disorder and had taken psychotropic medication for many years. After exclusion of other causes, the anticholinergic effect of the psychotropic medication must be taken as the cause of death. A review of literature and pharmacological receptor profiles are presented. Therapeutic consequences are described in order to prevent more cases of death...
June 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28629634/-123-i-fp-cit-spect-imaging-in-blepharospasm
#2
M De Verdal, D Renard, L Collombier, G Castelnovo
INTRODUCTION: Blepharospasm is a focal dystonia characterized by involuntary cocontraction of the eyelid protractors, causing spasmodic closure of the eyelids. Apraxia of eyelid opening is caused by an inability to initiate lid opening without paralytic abnormality. Some studies suggest that patients with either pure blepharospasm or blepharospasm associated with apraxia of eyelid opening are more prone to developing Parkinson's disease. METHODS: In our study, (123)I-FP-CIT (DAT) SPECT was performed in 24 patients with either pure blepharospasm or blepharospasm associated with apraxia of eyelid opening and no signs of parkinsonism to identify dopaminergic dysfunction...
June 16, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28616979/proposed-biotransformation-pathways-for-new-metabolites-of-paralytic-shellfish-toxins-based-on-field-and-experimental-mussel-samples
#3
Ling Ding, Jiangbing Qiu, Aifeng Li
A seafood poisoning event occurred in Qinhuangdao City, China, in April 2016. Subsequently, the causative mussels (Mytilus galloprovincialis) were harvested and analyzed to reveal a high concentration (~10,758 μg STX eq. kg-1) of paralytic shellfish toxins (PST), including GTX1/4 and GTX2/3, as well as new metabolites 11-hydroxy-STX (M2), 11,11-dihydroxy-STX (M4), open-ring 11,11-dihydroxy-STX (M6), 11-hydroxy-NEO (M8), and 11,11-dihydroxy-NEO (M10). In order to understand the origin and biotransformation pathways of these new metabolites, uncontaminated mussels (M...
June 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28601274/rocuronium-should-be-the-default-paralytic-in-rapid-sequence-intubation
#4
Anand K Swaminathan, Haney Mallemat
No abstract text is available yet for this article.
June 7, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28592028/-analysis-of-12-cases-of-exogenous-lipoid-pneumonia-confirmed-by-pathology
#5
Y X Wang, F Fang, Y F Guo, Y M Li, T Y Sun, M Zhang, J Chen, B M Fang
Objective: To study the etiological, clinical, radiological, diagnostic, therapeutic, and prognostic manifestations of exogenous lipoid pneumonia (ELP), and therefore to improve the diagnosis and treatment of this disease. Methods: The clinical data of 12 cases of ELP confirmed by pathology were retrospectively analyzed. Results: The patients consisted of 9 males and 3 females, with an average age of 73.8 years (range, 44 to 100 years). The underlying diseases were variable, including diseases affecting the general condition (multiple organ failure, chronic heart and renal insufficiency, pemphigoid, etc) and conditions with increased risk of aspiration (sequelae of cerebrovascular disease, Alzheimer's disease, advanced stage of nasopharyngeal carcinoma, paralytic ileus, etc)...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28587138/toxin-variability-estimations-of-68-alexandrium-ostenfeldii-dinophyceae-strains-from-the-netherlands-reveal-a-novel-abundant-gymnodimine
#6
Helge Martens, Urban Tillmann, Kirsi Harju, Carmela Dell'Aversano, Luciana Tartaglione, Bernd Krock
Alexandrium ostenfeldii is a toxic dinoflagellate that has recently bloomed in Ouwerkerkse Kreek, The Netherlands, and which is able to cause a serious threat to shellfish consumers and aquacultures. We used a large set of 68 strains to the aim of fully characterizing the toxin profiles of the Dutch A. ostenfeldii in consideration of recent reports of novel toxins. Alexandrium ostenfeldii is known as a causative species of paralytic shellfish poisoning, and consistently in the Dutch population we determined the presence of several paralytic shellfish toxins (PST) including saxitoxin (STX), GTX2/3 (gonyautoxins), B1 and C1/C2...
May 26, 2017: Microorganisms
https://www.readbyqxmd.com/read/28579583/a-case-of-intussusceptions-at-two-parts-of-the-ileum-caused-by-an-ileus-tube
#7
Yutaka Okagawa, Kohichi Takada, Hiroki Sakamoto, Takumi Miura, Shigeki Abeshima, Junji Kato
An 87-year-old woman was admitted to our hospital for paralytic ileus, and she was treated using an ileus tube. Although her symptoms improved, abdominal fullness developed again on day 3 after ileus tube insertion. Abdominal computed tomography indicated intussusceptions at the ileum and the terminal part of the ileum;therefore, an emergency surgery was performed. During the surgery, antegrade intussusceptions were found in the ileum 60cm from the ileocecal valve and the terminal part of the ileum into the ascending colon...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28566174/role-of-the-other-babinski-sign-in-hyperkinetic-facial-disorders
#8
Sara Varanda, Sofia Rocha, Margarida Rodrigues, Álvaro Machado, Gisela Carneiro
BACKGROUND: The "other Babinski sign" consists in the co-contraction of the orbicularis and frontalis muscles, causing an eyebrow elevation during ipsilateral eye closure. It cannot be voluntarily reproduced. AIMS OF THE STUDY: To determine the utility of this sign in the differential diagnosis of hyperkinetic facial disorders. METHODS: The presence of the sign was assessed in consecutive patients with blepharospasm, primary hemifacial spasm or post-paralytic facial syndrome treated in a botulinum toxin outpatient clinic...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28552040/functional-outcomes-following-anterior-transfer-of-the-tibialis-posterior-tendon-for-foot-drop-secondary-to-peroneal-nerve-palsy
#9
Byung-Ki Cho, Kyoung-Jin Park, Seung-Myung Choi, Se-Hyuk Im, Nelson F SooHoo
BACKGROUND: This retrospective comparative study reports the practical function in daily and sports activities after tibialis posterior tendon transfer for foot drop secondary to peroneal nerve palsy. METHODS: Seventeen patients were followed for a minimum of 3 years after tibialis posterior tendon transfer for foot drop secondary to peroneal nerve palsy. Matched controls were used to evaluate the level of functional restoration. Functional evaluations included American Orthopaedic Foot & Ankle Society (AOFAS) scores, Foot and Ankle Outcome Score (FAOS), Foot and Ankle Ability Measure (FAAM) scores, and isokinetic muscle strength test...
June 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28546813/a-case-of-urachal-carcinoma-of-the-abdominal-wall-in-a-kidney-transplant-recipient
#10
Takuya Yamazaki, Yasushi Nagaba, Yoshitaka Shimada, Yoshinori Taoka, Satoru Minamida, Dai Koguchi, Masahiro Hagiwara, Sho Watanuki, Hide Nagaba, Kazunari Yoshida, Yasuo Takeuchi
Urachal carcinoma is an extremely rare malignant tumor arising from the urachus in the fetus. We report a patient who developed urachal carcinoma 18 years after kidney transplantation. A 59-year-old man was admitted because of abdominal pain and massive ascites. He had undergone kidney transplantation 18 years earlier and had end-stage renal disease requiring dialysis. Abdominal CT showed massive ascites and an abdominal wall cystic mass separated from the peritoneal cavity. Hemodialysis was started, and paralytic ileus was diagnosed and treated...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28545474/a-retrospective-study-to-assess-the-evaluation-of-living-related-kidney-donors-and-their-outcomes-following-nephrectomy-at-kenyatta-national-hospital
#11
A Muturi, V Kotecha, S Kanyi
BACKGROUND: Kidney transplantation is the renal replacement therapy of choice for end stage renal disease. To ensure safety regular audit of the donation process is necessary. The aim of this study was to assess the evaluation of potential living related kidney donors and document their outcomes following nephrectomy. METHODS: This was a retrospective descriptive study involving all living related kidney donors seen at Kenyatta National Hospital (KNH) renal unit from 2010 to 2014...
May 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28544556/electrophysiological-analysis-of-synaptic-transmission-in-drosophila
#12
REVIEW
Maria Bykhovskaia, Alexander Vasin
Synaptic transmission is dynamic, plastic, and highly regulated. Drosophila is an advantageous model system for genetic and molecular studies of presynaptic and postsynaptic mechanisms and plasticity. Electrical recordings of synaptic responses represent a wide-spread approach to study neuronal signaling and synaptic transmission. We discuss experimental techniques that allow monitoring synaptic transmission in Drosophila neuromuscular and central systems. Recordings of synaptic potentials or currents at the larval neuromuscular junction (NMJ) are most common and provide numerous technical advantages due to robustness of the preparation, large and identifiable muscles, and synaptic boutons which can be readily visualized...
May 24, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28534855/rbc-adherence-of-immune-complexes-containing-botulinum-toxin-improves-neutralization-and-macrophage-uptake
#13
Fetweh H Al-Saleem, Rashmi Sharma, Rama Devudu Puligedda, Md Elias, Chandana Devi Kattala, Paul M Simon, Lance L Simpson, Scott K Dessain
In the paralytic disease botulism, the botulinum neurotoxin (BoNT) passes through the bloodstream to reach and inactivate neuromuscular junctions. Monoclonal antibodies (mAbs) may be useful BoNT countermeasures, as mAb combinations can rapidly clear BoNT from the blood circulation. We have previously shown that the BoNT-neutralizing potency of mAbs can be improved through red blood cell (RBC) immunoadherence. For example, a fusion protein (FP) that adheres biotinylated mAbs to the RBC surface enabled a pair of mAbs to neutralize 5000 LD50 BoNT/A in the mouse protection assay...
May 19, 2017: Toxins
https://www.readbyqxmd.com/read/28532167/how-the-marine-biotoxins-affect-human-health
#14
Silvia Morabito, Serena Silvestro, Caterina Faggio
Several marine microalgae produce dangerous toxins very damaging to human health, aquatic ecosystems and coastal resources. These Harmful Algal Blooms (HABs) in recent decades seem greatly increased regarding frequency, severity and biogeographical level, causing serious health risks as a consequence of the consumption of contaminated seafood. Toxins can cause various clinically described syndromes, characterised by a wide range of symptoms: amnesic (ASP), diarrhoetic (DSP), azaspirazid (AZP), neurotoxic (NSP) and paralytic (PSP) shellfish poisonings and ciguatera fish poisoning...
May 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28516259/-poisoning-caused-by-marine-biotoxins
#15
REVIEW
Philipp Hess
This paper presents a short summary of the knowledge on marine biotoxins. As toxins are known for their acute effects, they have been classified here according to the effects they cause in acute human poisoning incidents. Toxins may thus be distinguished into those that affect the nervous system (paralytic and other neurotoxins), memory (amnesic poisons), and the digestive system (diarrhetic toxins). Furthermore, newly emerging toxins, such as ciguatoxins or shark toxins, and factors that lead to the introduction of toxins in new areas, are presented...
May 17, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28514385/-the-effects-of-diosmin-and-hesperidin-on-capillary-blood-flow-of-upper-limbs-in-patients-with-secondary-raynaud-s-syndrome
#16
A M Zudin, A G Gritsenko, I T Hadzhishvili
The article discusses the effects of diosmin and hesperidin on capillary blood flow in patients with secondary Raynaud's syndrome (RS). Raynaud's syndrome a difficult problem of modern angiology, since in its development there is a large range of disorders of the capillary blood flow of the limbs. Currently, the main way of therapy in patients with secondary Raynaud's syndrome is the use of either calcium channel blockers (if angiospastic stage of the disease), or prostaglandins of group E1 (with tropho-paralytic stage of secondary RS)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28512689/long-term-results-of-fibular-achilles-tenodesis-westin-s-tenodesis-for-paralytic-pes-calcaneus-is-hypercorrection-avoidable-a-longitudinal-retrospective-study
#17
Helder Henzo Yamada, Patricia Maria Moraes de Barros Fucs
PURPOSE: The purpose of this study was to review all cases of patients submitted to Westin's tenodesis, who had calcaneus feet secondary to myelomeningocele sequel, in order to evaluate the anatomical change provided by surgery and also to verify, in a long-term follow-up, the inversion of the deformity depending on the patient's age. METHODS: In this longitudinal retrospective study, all medical records of patients with myelomeningocele sequelae submitted to Westin's tenodesis from 1993 to 2013 in a public university hospital were reviewed...
May 16, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28508942/-conservative-and-surgical-ileus-treatment
#18
H Listle, C Gutt
The diagnosis ileus is one of the most common indications for an emergency laparotomy. In 70% of the cases, the small intestine is affected, and in 30% it is the colorectum. While stuck hernias are a major cause in developing countries, the most common causes in western countries are postoperative adhesions that lead to an acute bowl obstruction. The timeframe for treatment of a complete mechanical obstruction is short as acute ischemia can lead to necrosis with bowl perforation within 6 h. The perioperative lethality for an emergency laparotomy due to an ileus ranges from 5-15%...
May 16, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28495477/quantification-of-saxitoxin-in-human-blood-by-elisa
#19
Rebekah E Wharton, Melanie C Feyereisen, Andrea L Gonzalez, Nicole L Abbott, Elizabeth I Hamelin, Rudolph C Johnson
Saxitoxin (STX) is a potent marine toxin that causes paralytic shellfish poisoning (PSP) which can result in significant morbidity and mortality in humans. Low lethal doses, rapid onset of PSP symptoms, and brief STX half-life in vivo require sensitive and rapid diagnostic techniques to monitor human exposures. Our laboratory has validated an enzyme-linked immunosorbent assay (ELISA) for quantitative detection of STX from 0.020 to 0.80 ng/mL in human whole blood and from 0.06 to 2.0 ng/mL in dried human blood which is simple, sensitive, rapid, and cost-effective...
July 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28492356/high-frequency-irreversible-electroporation-safety-and-efficacy-of-next-generation-irreversible-electroporation-adjacent-to-critical-hepatic-structures
#20
Imran A Siddiqui, Russell C Kirks, Eduardo L Latouche, Matthew R DeWitt, Jacob H Swet, Erin H Baker, Dionisios Vrochides, David A Iannitti, Rafael V Davalos, Iain H McKillop
Irreversible electroporation (IRE) is a nonthermal ablation modality employed to induce in situ tissue-cell death. This study sought to evaluate the efficacy of a novel high-frequency IRE (H-FIRE) system to perform hepatic ablations across, or adjacent to, critical vascular and biliary structures. Using ultrasound guidance H-FIRE electrodes were placed across, or adjacent to, portal pedicels, hepatic veins, or the gall bladder in a porcine model. H-FIRE pulses were delivered (2250 V, 2-5-2 pulse configuration) in the absence of cardiac synchronization or intraoperative paralytics...
June 2017: Surgical Innovation
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