Androgeny

Hereditární angioedém je vzácné dominantně dědičné onemocnění způsobené deficitem inhibitoru C1-esterázy (C1-INH). Onemocnění se klinicky projevuje recidivami lokalizovaných otoků podkoží a sliznic. Nemoc je hendikepující a může být i smrtelná. Charakteristická je extrémní variabilita v četnosti a závažnosti symptomů. Článek se zabývá organizací péče o pacienty a zahrnuje aktuální léčebné možnosti onemocnění. Strategie léčby zahrnuje krátkodobou a dlouhodobou profylaxi a léčbu atak...

INTRODUCTION: Cancer is a complex disorder whose detection and monitoring remains challenging. A biological modeling system, the biology of functions (BoF), claims to be able to evaluate physiologic elements related to carcinogenic activity. A pilot study was undertaken to evaluate the accuracy of the BoF in detecting differences between cancer cases and matched controls. MATERIALS AND METHODS: A retrospective case control study was performed using the BoF analyses of 46 patients with all types of solid and hematgenous cancers, active and inactive (total cases), and 46 controls from a private practice...

Questionnaire data from 195 college students were examined to clarify the relationships among masculinity, femininity, and androgyny and self-perceived flexibility and individualism. Analysis of variance (ANOVA) and hierarchical regression showed no evidence for unique positive "androgyny" effects, while higher masculinity was associated with flexibility and individualism, particularly among women. Contrary to expectations, "androgynous" men were more rigid and conforming, while the cross-typed were most flexible and independent...

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Analysis of the developmental capacities of androgenetic and gynogenetic mouse embryos (bearing two paternal or two maternal pronuclei, respectively) revealed a defect in blastocyst formation of androgenetic, but not gynogenetic, embryos that was a function of the maternal genotype. Androgenetic embryos constructed using fertilized eggs from C57BL/6 or (B6D2)F1 mice developed to the blastocyst stage at frequencies similar to those previously reported, whereas androgenetic embryos constructed with fertilized eggs from DBA/2 mice developed poorly, the majority failing to progress beyond the 16-cell stage and unable to form a blastocoel-like cavity, regardless of whether the male pronuclei were of C57BL6 or DBA/2 origin...

No abstract text is available yet for this article.