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https://www.readbyqxmd.com/read/29222058/differential-expression-of-the-immediate-early-genes-c-fos-arc-egr-1-and-npas4-during-long-term-memory-formation-in-the-context-preexposure-facilitation-effect-cpfe
#1
Nicholas A Heroux, Brittany F Osborne, Lauren A Miller, Malak Kawan, Katelyn N Buban, Jeffrey B Rosen, Mark E Stanton
No abstract text is available yet for this article.
December 5, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29214513/hyper-response-to-novelty-increases-c-fos-expression-in-the-hippocampus-and-prefrontal-cortex-in-a-rat-model-of-schizophrenia
#2
Tomas Monfil, Rubén Antonio Vázquez Roque, Israel Camacho-Abrego, Hiram Tendilla-Beltran, Tommaso Ianniti, Ivan Meneses-Morales, Patricia Aguilar-Alonso, Gonzalo Flores, Julio Cesar Morales-Medina
Schizophrenia is a debilitating disorder that may have a neurodevelopmental origin. For this reason, animal models based on neonatal insults or manipulations have been extensively used to demonstrate schizophrenia-related behaviors. Among those, the neonatal ventral hippocampus lesion (nVHL) is largely used as a model of schizophrenia-related behavior as it mimics behavioral and neurochemical abnormalities often seen in schizophrenic patients including hyperlocomotion in a novel environment. To investigate the neuroanatomical basis of coding novelty in the nVHL rat, we assessed the behavioral locomotor activity paradigm in a novel environment and measured expression of c-Fos, a marker of neural activation, in brain regions involved in the process of coding novelty or locomotion...
December 6, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29212295/inhibitory-effects-of-boesenbergia-pandurata-on-age-related-periodontal-inflammation-and-alveolar-bone-loss-in-fischer-344-rats
#3
Haebom Kim, Changhee Kim, Do Un Kim, Hee Chul Chung, Jae-Kwan Hwang
Periodontitis, an infective disease caused by oral pathogens and the intrinsic aging process, results in the destruction of periodontal tissues and alveolar bone loss. This study investigated whether Boesenbergia pandurata extract (BPE) standardized with panduratin A exerted anti-periodontitis effects using an aging model representative of naturally occurring periodontitis. In aged rats, the oral administration of BPE (200 mg/kg/day) for 8 weeks significantly reduced the mRNA and protein expression of interleukin (IL)-1β, nuclear factor-kappaB (NF-κB), matrix metalloproteinase (MMP)-2, and MMP-8 in gingival tissues (p < 0...
December 8, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29210146/central-administration-of-galanin-n-terminal-fragment-1-15-decreases-the-voluntary-alcohol-intake-in-rats
#4
Carmelo Millón, Antonio Flores-Burgess, Estela Castilla-Ortega, Belén Gago, María García-Fernandez, Antonia Serrano, Fernando Rodriguez de Fonseca, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabiale
Alcohol consumption is considered a major risk factor for disease and mortality worldwide. In the absence of effective treatments in alcohol use disorders, it is important to find new biological targets that could modulate alcohol consumption. We tested the role of the N-terminal galanin fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the two-bottle choice paradigm as well as compare the effects of GAL(1-15) with the whole molecule of GAL. We describe for the first time that GAL(1-15), via central mechanisms, induces a strong reduction in preference and ethanol consumption in rats...
December 6, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29209167/heme-oxygenase-1-induction-by-carbon-monoxide-releasing-molecule-3-suppresses-interleukin-1%C3%AE-mediated-neuroinflammation
#5
Chih-Chung Lin, Chien-Chung Yang, Li-Der Hsiao, Ssu-Yu Chen, Chuen-Mao Yang
Neurodegenerative disorders and brain damage are initiated by excessive production of reactive oxygen species (ROS), which leads to tissue injury, cellular death and inflammation. In cellular anti-oxidant systems, heme oxygenase-1 (HO-1) is an oxidative-sensor protein induced by ROS generation or carbon monoxide (CO) release. CO releasing molecules (CORMs), including CORM-3, exert anti-oxidant and anti-inflammatory effects. However, the molecular mechanisms of CORM-3-induced HO-1 expression and protection against interleukin (IL)-1β-induced inflammatory responses have not been fully elucidated in rat brain astrocytes (RBA-1)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29208967/a-selective-inhibition-of-c-fos-activator-protein-1-as-a-potential-therapeutic-target-for-intervertebral-disc-degeneration-and-associated-pain
#6
Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimura
Intervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogenesis IVD degeneration. We investigated the effects of inhibition of c-Fos/AP-1 on IVD degeneration and associated pain. A selective inhibitor, T-5224, significantly suppressed the interleukin-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207140/platelet-rich-plasma-inhibits-rankl-induced-osteoclast-differentiation-through-activation-of-wnt-pathway-during-bone-remodeling
#7
Dongyue Wang, Yajuan Weng, Shuyu Guo, Yuxin Zhang, Tingting Zhou, Mengnan Zhang, Lin Wang, Junqing Ma
Platelet-rich plasma (PRP) is used in the clinic as an autologous blood product to stimulate bone regeneration and chondrogenesis. Numerous studies have demonstrated that PRP affects bone remodeling by accelerating osteoblast formation. With the research perspective focusing on osteoclasts, the present study established a mouse model of mandibular advancement to examine the effect of PRP on osteoclast differentiation induced by modification of the dynamics of the temporomandibular joint (TMJ). The lower incisors of the mice were trimmed by 1 mm and the resultant change in mandibular position during the process of eating induced condylar adaptation to this change...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205377/adenosine-a2a-receptors-are-required-for-glutamate-mglur5-and-dopamine-d1-receptor-evoked-erk1-2-phosphorylation-in-rat-hippocampus-involvement-of-nmda-receptor
#8
Paraskevi Krania, Eleni Dimou, Maria Bantouna, Stylianos Kouvaros, Eirini Tsiamaki, Costas Papatheodoropoulos, Konstantinos Sarantis, Fevronia Angelatou
Interaction between mGluR5 and NMDA receptors (NMDAR) is vital for synaptic plasticity and cognition. We recently demonstrated that stimulation of mGluR5 enhances NMDAR-responses in hippocampus by phosphorylating NR2B(Tyr1472) subunit, and this reaction was enabled by adenosine A2A receptors(A2A R) (Sarantis et al.2015). In this study, by using in vitro phosphorylation and western blot analysis in hippocampal slices of male Wistar rats, we show, that mGluR5 stimulation or mGluR5/NMDARs co-stimulation, synergistically activate ERK1/2 signaling leading to c-Fos expression...
December 5, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29205090/rapamycin-exacerbates-cardiovascular-dysfunction-after-complete-high-thoracic-spinal-cord-injury
#9
Khalid C Eldahan, David H Cox, Jenna L Gollihue, Samir P Patel, Alexander G Rabchevsky
Autonomic dysreflexia (AD) is a potentially life-threatening syndrome in individuals with spinal cord injury (SCI) above the T6 spinal level that is characterized by episodic hypertension in response to noxious stimuli below the lesion. Maladaptive intraspinal plasticity is thought to contribute to the temporal development of AD, and experimental approaches that reduce such plasticity mitigate the severity of AD. The mammalian target of rapamycin (mTOR) has gained interest as a mediator of plasticity, regeneration and nociceptor hypersensitivity in the injured spinal cord...
December 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29204804/influence-of-preoptic-estradiol-on-behavioral-and-neural-response-to-cocaine-in-female-sprague-dawley-rats
#10
Christopher L Robison, Julia R Martz, Juan M Dominguez
RATIONALE: Systemic estradiol (E2) increases the behavioral and neural response to cocaine. Where in the brain E2 acts to modulate cocaine response is not entirely clear. Evidence supports a role in this modulation for several candidate regions, including the medial preoptic area (mPOA). OBJECTIVES: This study examined whether manipulation of E2 in the mPOA modulates differing behavioral responses to cocaine and whether this is reflected in differing levels of c-Fos in the NAc following cocaine administration...
December 4, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29203334/sex-differences-in-olfactory-induced-neural-activation-of-the-amygdala
#11
Takefumi Kikusui, Mayu Kajita, Natsumi Otsuka, Tatsuya Hattori, Kanako Kumazawa, Akiyuki Watarai, Miho Nagasawa, Ayumu Inutsuka, Akihiro Yamanaka, Naoki Matsuo, Herbert E Covington, Kazutaka Mogi
Olfactory signals, including the scent of urine, are thought to be processed by specific brain regions, such as the medial amygdala (Me), and regulate sexual behavior in a sex-dependent manner. We aimed to reveal the sex-specific neural circuit from the accessory olfactory bulb (AOB) to Me by using a transgenic mouse. We quantified the long-lasting green fluorescent protein (GFP) expression profile, which was controlled by the c-fos promotor in a sex-dependent manner by the scent of urine. Female urine predominantly activated neurons of the MePD in male mice and the MePV in female mice...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29200178/induction-of-chronic-migraine-phenotypes-in-a-rat-model-after-environmental-irritant-exposure
#12
Phillip Edward Kunkler, LuJuan Zhang, Philip Lee Johnson, Gerry Stephen Oxford, Joyce Harts Hurley
Air pollution is linked to increased emergency room visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well-understood. We previously reported that chronic environmental irritant exposure sensitizes the trigeminovascular system response to nasal administration of environmental irritants. Here, we examine whether chronic environmental irritant exposure induces migraine behavioral phenotypes. Male rats were exposed to acrolein, a TRPA1 agonist, or room air by inhalation for 4 days prior to meningeal blood flow measurements, periorbital cutaneous sensory testing or other behavioral testing...
December 1, 2017: Pain
https://www.readbyqxmd.com/read/29197622/protective-effects-of-dioscin-against-fructose-induced-renal-damage-via-adjusting-sirt3-mediated-oxidative-stress-fibrosis-lipid-metabolism-and-inflammation
#13
Yujie Qiao, Lina Xu, Xufeng Tao, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Zeyao Tang, Xiaodong Ma, Kexin Liu, Jinyong Peng
In the present work, the effects and possible mechanisms of dioscin, one natural product from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose-induced renal injury in rats were tested. The results showed that dioscin significantly restored fructose-induced renal injury by decreasing the levels of Cr, BUN, and rehabilitating histopathological changes. In addition, dioscin markedly adjusted the levels of MDA, SOD and GSH-Px, reduced ROS level in renal tissue, and decreased the levels of TG, FFA, α-SMA and COL1A...
December 2, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29196218/stress-induced-hippocampus-npas4-mrna-expression-relates-to-specific-psychophysiological-patterns-in-stress-response
#14
Jean-Baptiste Drouet, André Peinnequin, Patrice Faure, Josiane Denis, Nadine Fidier, Renaud Maury, Alain Buguet, Raymond Cespuglio, Frédéric Canini
Neuronal Per-Arnt-Sim (PAS) domain protein4 (Npas4) is a key protein that intervenes in GABA synapse scaling and neurotrophicity enhancing. Since GABA and neurotrophicity are implicated in stress response and Npas4-deficient rodents exhibit behavioral alterations, an investigation was designed in rats to verify whether stress-induced spontaneous hippocampus Npas4 mRNA expression would be associated with specific patterns of stress response. The rats were exposed to one of three stressor levels: no stress (CTL, n=15), exposure to a footshock apparatus (Sham, S, n=40) and footshock (F, n=80)...
November 28, 2017: Brain Research
https://www.readbyqxmd.com/read/29195839/the-ventromedial-hypothalamic-nucleus-plays-an-important-role-in-anxiolytic-like-effect-of-neuropeptide-s
#15
Jin Hong Jiang, Ya Li Peng, Pei Jiang Zhang, Hong Xiang Xue, Zhen He, Xue Ya Liang, M Chang
Neuropeptide S (NPS), the endogenous neuropeptide ligand of NPSR, has been reported to regulate anxiety-related behavior involved in multiple brain regions, including amygdale, locus coeruleus and Barrington's nucleus. However, little research has been conducted on the anxiolytic-like behaviors of NPS on the hypothalamus, which was an important area in defensive behavior. Here, we investigated a role of hypothalamus in anxiolytic-like behaviors of NPS. We found that NPSR protein of mouse distributed mainly in the ventromedial hypothalamus (VMH)...
November 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29194604/effects-of-microrna-129-and-its-target-gene-c-fos-on-proliferation-and-apoptosis-of-hippocampal-neurons-in-rats-with-epilepsy-via-the-mapk-signaling-pathway
#16
Yu-Tong Zhang
This study aims to investigate the effect of microRNA-129 (miR-129) on proliferation and apoptosis of hippocampal neurons in epilepsy rats by targeting c-Fos via the MAPK signaling pathway. Thirty rats were equally classified into a model group (successfully established as chronic epilepsy models) and a control group. miR-129, c-Fos, bax and MAPK expressions were detected by RT-qPCR and Western blotting. Hippocampal neurons were assigned into normal, blank, negative control (NC), miR-129 mimic, miR-129 inhibitor, siRNA-c-Fos, miR-129 inhibitor + siRNA-c-Fos groups...
November 30, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29192233/kaempferide-prevents-titanium-particle-induced-osteolysis-by-suppressing-jnk-activation-during-osteoclast-formation
#17
Zixian Jiao, Weifeng Xu, Jisi Zheng, Pei Shen, An Qin, Shanyong Zhang, Chi Yang
Kaempferide (KF) is an O-methylated flavonol, a natural plant extract, which is often found in Kaempferia galanga. It has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties. In this study, we aimed to investigate whether KF effectively inhibits titanium particle induced calvarial bone loss via down regulation of the JNK signaling pathway. In the mice with titanium particle induced calvarial osteolysis, the Low dose of KF mildly reduced the resorption pits while in the high dose group, fewer scattered pits were observed on the surface of calvarium...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192229/seasonal-expression-of-oxytocin-and-oxytocin-receptor-in-the-scented-gland-of-male-muskrat-ondatra-zibethicus
#18
Fengwei Zhang, Qian Liu, Ziyi Wang, Wenqian Xie, Xia Sheng, Haolin Zhang, Zhengrong Yuan, Yingying Han, Qiang Weng
Oxytocin (OT) can modulate multiple physiological functions via binding to the widely distributed oxytocin receptor (OTR). In this study, we investigated the seasonal expressions of OT, OTR and extracellular signal regulated kinase (ERK1/2) signaling pathway components in the scented gland of muskrat during the breeding and non-breeding seasons. Histologically, glandular cells, interstitial cells and excretory tubules were identified in the breeding season scented glands, whereas epithelial cells were sparse in the non-breeding season...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186377/oxytocin-oxytocin-receptor-systems-facilitate-social-defeat-posture-in-male-mice
#19
Naranbat Nasanbuyan, Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Katsuhiko Nishimori, Akihiro Yamanaka, Tatsushi Onaka
Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics, i.e., social defeat stress, evokes species-specific defeat posture via unknown mechanisms. Oxytocin neurons have been shown to be activated by stressful stimuli and to have pro-social and anxiolytic actions. The roles of oxytocin during social defeat stress remain unclear. Expression of c-Fos, a marker of neuronal activation, in oxytocin neurons and in oxytocin receptor-expressing neurons was investigated in mice...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29182617/in-vivo-stimulation-of-locus-coeruleus-effects-on-amygdala-subnuclei
#20
Elisa Rodríguez-Ortega, Fernando Cañadas, Francisca Carvajal, Diana Cardona
The locus coeruleus (LC) is the major noradrenergic nucleus and sends projections to almost all brain areas. A marked increase in norepinephrine release has been demonstrated in several brain areas in response to exposure to acute stressful stimuli, especially those innervated by LC projections. One of the brain areas innervated by LC neurons is the amygdala, a structure highly involved in emotional processes and memory formation. The aim of this study was to increase knowledge of the functional connectivity between the LC and the amygdala subnuclei...
2017: Acta Neurobiologiae Experimentalis
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