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https://www.readbyqxmd.com/read/27915481/effects-of-combination-treatment-of-alpha-1-adrenergic-receptor-antagonists-on-voiding-dysfunction-study-on-target-organs-in-overactive-bladder-rats
#1
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#2
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27913299/the-inhibitory-effect-of-beta-lapachone-on-rankl-induced-osteoclastogenesis
#3
Dong Ryun Gu, Joon No Lee, Gi-Su Oh, Hyung Jin Kim, Min Seuk Kim, Seoung Hoon Lee
β-lapachone (β-L) is a substrate of reduced nicotinamide adenine dinucleotide (NADH): quinone oxidoreductase 1 (NQO1). NQO1 reduces quinones to hydroquinones using NADH as an electron donor and consequently increases the intracellular NAD+/NADH ratio. The activation of NQO1 by β-L has beneficial effects on several metabolic syndromes, such as obesity, hypertension, and renal injury. However, the effect of β-L on bone metabolism remains unclear. Here, we show that β-L might be a potent inhibitor of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis...
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27912885/tetrandrine-an-alkaloid-from-s-tetrandra-exhibits-anti-hypertensive-and-sleep-enhancing-effects-in-shr-via-different-mechanisms
#4
Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
BACKGROUND: Sleep disorders have been found to be associated with hypertension in both cross-sectional and longitudinal epidemiological studies. Tetrandrine, a major component of Stephania tetrandra, is well known as an antihypertensive agent. The anti-hypertension mechanism mainly relies on its L-type calcium channel blocking property. In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). PURPOSE: This study aims to elucidate whether the antihypertensive mechanism of tetrandrine in SHRs is relevant to its hypnotic effect...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912882/tenuifolin-a-saponin-derived-from-radix-polygalae-exhibits-sleep-enhancing-effects-in-mice
#5
Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported that tenuifolin was a major constituent of polygalasaponins. PURPOSE: The currently study aims to investigate the hypnotic effect and possible mechanism of tenuifolin in freely moving mice...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27906434/effect-and-mechanism-of-par-2-on-the-proliferation-of-esophageal-cancer-cells
#6
D Quanjun, Z Qingyu, Z Qiliang, X Liqun, C Jinmei, L Ziquan, H Shike
OBJECTIVE: Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. MATERIALS AND METHODS: Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109) was established with low stable PAR-2 expression. EC109 cell was treated with PAR-2 agonist, PAR-2 anti-agonist and MAPK inhibitor respectively; Untreated EC109 cell (blank control) and PAR-2shRNA EC109 cell were used for analysis also...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27904658/circulating-microparticles-enhanced-rat-vascular-wall-remodeling-following-endothelial-denudation
#7
Fan-Yen Lee, Hung-I Lu, Han-Tan Chai, Jiunn-Jye Sheu, Yi-Ling Chen, Tein-Hung Huang, Gour-Shenq Kao, Sheng-Yi Chen, Sheng-Ying Chung, Pei-Hsun Sung, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that circulating microparticles (MPs) exacerbated vascular wall (VW) remodeling after endothelial denudation by 0.014 wire in a rat model. Adult male Sprague Dawley rats (n = 40) were equally categorized into group 1 [sham-control (SC); 3.0 mL saline intravenous injection], group 2 [SC + intravenous MPs (1.0 × 10(7)) derived from patients with carotid artery stenosis (CAS)], group 3 [femoral arterial endothelial denudation (FAED)], group 4 (FAED + MPs derived from healthy subjects), and group 5 (FAED + CAS-derived MPs)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27903990/baicalein-reduces-angiogenesis-in-the-inflammatory-microenvironment-via-inhibiting-the-expression-of-ap-1
#8
Yujie Huang, Zhaorui Miao, Yang Hu, Yang Yuan, Yuxin Zhou, Libin Wei, Kai Zhao, Qinglong Guo, Na Lu
Increasing clinical and experimental studies have demonstrated that refractory chronic inflammation will result in malignant tumor and anti-angiogenic therapy may be an effective way to thwart the progression. Baicalein, one of the major active flavanoids found in Scutellaria baicalensis Georgi, has been exhibited potent anti-inflammation and anti-tumor effects by reducing angiogenesis. However, the exact mechanism of baicalein on endothelial cells in inflammatory microenvironment was not clear yet. Here, we investigated the anti-angiogenic effect of baicalein by incubating human umbilical vein endothelial cells (HUVECs) with THP-1 conditioned medium in vitro...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903705/organization-of-the-claustrum-to-entorhinal-cortical-connection-in-mice
#9
Takuma Kitanishi, Naoki Matsuo
: The claustrum, a subcortical structure situated between the insular cortex and striatum, is reciprocally connected with almost all neocortical regions. Based on this connectivity, the claustrum has been postulated to integrate multisensory information and, in turn, coordinate widespread cortical activity. While studies have identified how sensory information is mapped onto the claustrum, the function of individual topographically-arranged claustro-cortical pathways has been little explored...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27898076/growth-hormone-biases-amygdala-network-activation-after-fear-learning
#10
B Gisabella, S Farah, X Peng, A Burgos-Robles, S H Lim, K A Goosens
Prolonged stress exposure is a risk factor for developing posttraumatic stress disorder, a disorder characterized by the 'over-encoding' of a traumatic experience. A potential mechanism by which this occurs is through upregulation of growth hormone (GH) in the amygdala. Here we test the hypotheses that GH promotes the over-encoding of fearful memories by increasing the number of neurons activated during memory encoding and biasing the allocation of neuronal activation, one aspect of the process by which neurons compete to encode memories, to favor neurons that have stronger inputs...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27896363/oxygen-ultra-fine-bubbles-water-administration-prevents-bone-loss-of-glucocorticoid-induced-osteoporosis-in-mice-by-suppressing-osteoclast-differentiation
#11
T Noguchi, K Ebina, M Hirao, T Morimoto, K Koizumi, K Kitaguchi, H Matsuoka, T Iwahashi, H Yoshikawa
: Oxygen ultra-fine bubbles (OUB) saline injection prevents bone loss of glucocorti\coid-induced osteoporosis in mice, and OUB inhibit osteoclastogenesis via RANK-TRAF6-c-Fos-NFATc1 signaling and RANK-p38 MAPK signaling in vitro. INTRODUCTION: Ultra-fine bubbles (<200 nm in diameter) have several unique properties, and they are tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUB) on glucocorticoid-induced osteoporosis (GIO) model mice...
November 28, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27895618/cyclooxygenase-1-as-a-potential-therapeutic-target-for-seizure-suppression-evidences-from-zebrafish-pentylenetetrazole-seizure-model
#12
Patrícia Gonçalves Barbalho, Benilton de Sá Carvalho, Iscia Lopes-Cendes, Claudia Vianna Maurer-Morelli
Cyclooxygenases (COX)-1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process. COX-2 isoform has been predominantly explored as the most suitable target for pharmacological intervention in epilepsy studies, while COX-1 remains poorly investigated. In the present study, we evaluated the effects of selective COX-1 inhibitor or selective COX-2 inhibitor on seizure suppression in the zebrafish pentylenetetrazole (PTZ)-seizure model...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27889766/telencephalic-neuronal-activation-associated-with-spatial-memory-in-the-terrestrial-toad-rhinella-arenarum-participation-of-the-medial-pallium-during-navigation-by-geometry
#13
María Inés Sotelo, M Florencia Daneri, Verner Peter Bingman, Rubén N Muzio
Amphibians are central to discussions of vertebrate evolution because they represent the transition from aquatic to terrestrial life, a transition with profound consequences for the selective pressures shaping brain evolution. Spatial navigation is one class of behavior that has attracted the interest of comparative neurobiologists because of the relevance of the medial pallium/hippocampus, yet, surprisingly, in this regard amphibians have been sparsely investigated. In the current study, we trained toads to locate a water goal relying on the boundary geometry of a test environment (Geometry-Only) or boundary geometry coupled with a prominent, visual feature cue (Geometry-Feature)...
November 26, 2016: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/27887635/anisakis-pegreffii-nematoda-anisakidae-products-modulate-oxidative-stress-and-apoptosis-related-biomarkers-in-human-cell-lines
#14
Concetta Maria Messina, Federica Pizzo, Andrea Santulli, Ivana Bušelić, Mate Boban, Stjepan Orhanović, Ivona Mladineo
BACKGROUND: In countries with elevated prevalence of zoonotic anisakiasis and high awareness of this parasitosis, a considerable number of cases that associate Anisakis sp. (Nematoda, Anisakidae) and different bowel carcinomas have been described. Although neoplasia and embedded larvae were observed sharing the common site affected by chronic inflammation, no association between the nematode and malignancy were directly proved. Similarly, no data are available about the effect of secretory and excretory products of infecting larvae at the host's cellular level, except in respect to allergenic interaction...
November 25, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27882999/activation-of-ventral-tegmental-area-5-ht2c-receptors-reduces-incentive-motivation
#15
Lourdes Valencia-Torres, Cristian M Olarte-Sánchez, David J Lyons, Teodora Georgescu, Megan Greenwald-Yarnell, Martin G Myers, Christopher M Bradshaw, Lora K Heisler
Obesity is primarily due to food intake in excess of the body's energetic requirements, intake that is not only associated with hunger but also the incentive value of food. The 5-hydroxytryptamine 2C receptor (5-HT2CR) is a target for the treatment of human obesity. Mechanistically, 5-HT2CRs are positioned to influence both homeostatic feeding circuits within the hypothalamus and reward circuits within the ventral tegmental area (VTA). Here we investigated the role of 5-HT2CRs in incentive motivation using a mathematical model of progressive ratio (PR) responding in mice...
November 24, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27881080/genotypic-differences-in-intruder-evoked-immediate-early-gene-activation-in-male-but-not-female-vasopressin-1b-receptor-knockout-mice
#16
Shannah K Witchey, Erica L Stevenson, Heather K Caldwell
BACKGROUND: The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal aggressive behaviors and social recognition memory. However, this brain area is just one part of a larger neural circuit that is likely to be impacted in Avpr1b knockout (-/-) mice...
November 24, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27876668/activation-of-the-orbitofrontal-and-anterior-cingulate-cortices-during-the-expression-of-a-naturalistic-compulsive-like-behavior-in-the-rabbit
#17
Hugo Cano-Ramírez, Kurt L Hoffman
We propose that maternal nest building in the female laboratory rabbit is a useful model for compulsions in obsessive-compulsive disorder (OCD). This repetitive behavior comprises collecting straw, depositing it into the nest box, and then returning to collect more straw. We reasoned that if "straw carrying" behavior is homologous to compulsive behavior, then it should be associated with activation of prefrontal regions associated with OCD, namely, the orbitofrontal and anterior cingulate cortices (OFC and ACC, respectively)...
November 19, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27873445/the-motion-of-a-living-conspecific-activates-septal-and-preoptic-areas-in-naive-domestic-chicks-gallus-gallus
#18
Uwe Mayer, Orsola Rosa-Salva, Francesca Morbioli, Giorgio Vallortigara
Predispositions to attend to animate objects are ubiquitous in newborn vertebrates but little is known about their neural bases. In the present study we wanted to know if exposure to the motion of an alive, behaving conspecific will selectively activate septal, preoptic and amygdaloid areas in visually naive domestic chicks. For this purpose, newly hatched chicks were exposed to an alive conspecific, whose natural motion presents of course several features typical of animate motion to which chicks are known to be sensitive...
November 22, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27870439/estradiol-shifts-interactions-between-the-infralimbic-cortex-and-central-amygdala-to-enhance-fear-extinction-memory-in-female-rats
#19
Lisa Y Maeng, Kara K Cover, Mohamad B Taha, Aaron J Landau, Mohammed R Milad, Kelimer Lebrón-Milad
There is growing evidence that estradiol (E2) enhances fear extinction memory consolidation. However, it is unclear how E2 influences the nodes of the fear extinction network to enhance extinction memory. This study begins to delineate the neural circuits underlying the influence of E2 on fear extinction acquisition and consolidation in female rats. After fear conditioning (day 1), naturally cycling female rats underwent extinction learning (day 2) in a low-E2 state, receiving a systemic administration of either E2 or vehicle prior to extinction training...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27866934/pharmacodynamic-action-and-mechanism-of-du-liang-soft-capsule-a-traditional-chinese-medicine-capsule-on-treating-nitroglycerin-induced-migraine
#20
Min Hou, Qing Tang, Qiang Xue, Xiaona Zhang, Yang Liu, Sheng Yang, Liechun Chen, Xiaoyu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Du Liang soft capsule (DL) is a traditional Chinese medicine for treating migraines; it is made from two Chinese herbs, including LigusticumstriatumDC., root; Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., root. AIM OF THE STUDY: In the present study, we aimed to elucidate the pharmacodynamic action of DL and its mechanism in an animal model of migraines induced by glyceryl trinitrate (GTN). MATERIALS AND METHODS: Sixty rats were randomly divided into six groups, including a normal control group, model control group, positive group (Sumatriptan 0...
November 17, 2016: Journal of Ethnopharmacology
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