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https://www.readbyqxmd.com/read/28078553/expression-of-apoptosis-regulatory-genes-in-the-hippocampus-of-rat-neonates-born-to-mothers-with-diabetes
#1
Hossein Haghir, Javad Hami, Nassim Lotfi, Mostafa Peyvandi, Simagol Ghasemi, Mehran Hosseini
Diabetes during pregnancy impairs the development of the central nervous system (CNS) and causes cognitive and behavioral abnormalities in offspring. However, the exact mechanism by which the maternal diabetes affects the development of the brain remains to be elucidated. The aim of the present study was to investigate the effects of maternal diabetes in pregnancy on the expression of Bcl-2 and Bax genes and the numerical density of degenerating dark neurons (DNs) in the hippocampus of offspring at the first postnatal two weeks...
January 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28077135/comorbidity-study-of-borderline-personality-disorder-applying-association-rule-mining-to-the-taiwan-national-health-insurance-research-database
#2
Cheng-Che Shen, Li-Yu Hu, Ya-Han Hu
BACKGROUND: Borderline personality disorder (BPD) is a complex clinical state with highly polymorphic symptoms and signs. Studies have demonstrated that people with a BPD diagnosis are likely to have numerous co-occurring psychiatric disorders and physical comorbidities. The aim of our study was to obtain further insight about the associations among comorbidities of BPD and to demonstrate the practicality of using association rule mining (ARM) technique in clinical databases. METHODS: A retrospective case-control study was conducted on information of 1460 patients (292 BPD patients and 1168 control patients) selected from the Taiwan National Health Insurance Research Database...
January 11, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28075445/a-clinical-and-molecular-analysis-of-a-patient-with-emanuel-syndrome
#3
Jin-Wen Luo, Huan Yang, Zhi-Ping Tan, Ming Tu, Hong Luo, Yi-Feng Yang, Li Xie
Emanuel syndrome (ES) is the most frequent type of recurrent non‑Robertsonian translocation that is characterized by numerous anomalies. Over 100 patients with ES have been described in the literature. The phenotype of this syndrome varies but often consists of facial dysmorphism, microcephaly, severe intellectual disability, developmental retardation, congenital heart disease and genital anomalies. The present study describes a 2‑year‑old boy with multiple malformations, including facial dysmorphism, severe intellectual disability, growth retardation, congenital heart disease, cleft lip and palate, genital malformation (micropenis), amblyopia, thymic dysplasia and hearing impairment...
January 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28073442/toward-predicting-dinophysis-blooms-off-nw-iberia-a-decade-of-events
#4
Ma Teresa Moita, Yolanda Pazos, Carlos Rocha, Rita Nolasco, Paulo B Oliveira
Dinophysis acuminata and Dinophysis acuta are recurrent species off NW Iberia but their outbreaks occur under different conditions. A decade (2004-2013) of weekly data for each species at two sentinel stations located at the entrance of Rias de Aveiro-AV (NW Portugal, 40°38.6'N) and Pontevedra-PO (Galicia, Spain, 42°21.5'N), were used to investigate the regional synchronism and mesoscale differences related to species detection, bloom (>200cellsL(-1)) initiation and development. Results highlight the high interannual variability of bloom events and summarize the associated meteorological/oceanographic conditions...
March 2016: Harmful Algae
https://www.readbyqxmd.com/read/28040119/are-congenital-malformations-more-frequent-in-fetuses-with-intrahepatic-persistent-right-umbilical-vein-a-comparative-study
#5
Ignacio Adiego-Calvo, Ricardo Saviron-Cornudella, Cristina Martinez-Payo, Encarna Rubio-Aranda, Javier Sancho-Sauco, Ana Isabel Cisneros-Gimeno, Pilar Perez-Perez, Diego Lerma-Puertas, Jaime Whyte-Orozco
OBJECTIVE: Persistent right umbilical vein (PRUV) is a vascular anomaly where the right umbilical vein remains as the only conduit that returns oxygenated blood to the fetus. It has classically been described as associated with numerous defects. We distinguish the intrahepatic variant (better prognosis) and the extrahepatic variant (associated with worse prognosis). The objective of this study was to compare rates of congenital malformations in fetuses with intrahepatic PRUV (I-PRUV) versus singleton pregnancies without risk factors...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28009316/-efficacy-of-combined-use-of-antioxidative-and-phototherapy-in-the-treatment-of-vitiligo
#6
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, Ts Tsiskarishvili, L Chitanava
Despite of numerous investigations, carried out practically in all countries of the world for the study of vitiligo and the search for its new effective therapies, pathogenic mechanisms of vitiligo are still poorly understood, and the proposed treatments are not perfect. One of the most accepted theories of the pathogenesis of vitiligo is an oxidative stress theory, according to which a series of biochemical anomalies cause oxidative stress, leading to accumulation of melanocytotoxic substances and inhibition of natural processes of detoxification with subsequent destruction of melanocytes in vitiligo focus...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27982444/solvent-mediated-non-electrostatic-ion-ion-interactions-predicting-anomalies-in-electrophoresis
#7
Prakash Goswami, Jayabrata Dhar, Uddipta Ghosh, Suman Chakraborty
We study the effects of solvent-mediated non-electrostatic ion-ion interactions on electrophoretic mobility of a charged spherical particle. To this end, we consider the case of low surface electrostatic potential resulting in the linearization of the governing equations, which enables us to deduce a closed-form analytical solution to the electrophoretic mobility. We subsequently compare our results to the standard model using Henry's approach and report the changes brought about by the non-electrostatic potential...
December 16, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27981065/art-3-5d-an-algorithm-to-label-arteries-and-veins-from-three-dimensional-angiography
#8
Beatrice Barra, Elena De Momi, Giancarlo Ferrigno, Guglielmo Pero, Francesco Cardinale, Giuseppe Baselli
Preoperative three-dimensional (3-D) visualization of brain vasculature by digital subtraction angiography from computerized tomography (CT) in neurosurgery is gaining more and more importance, since vessels are the primary landmarks both for organs at risk and for navigation. Surgical embolization of cerebral aneurysms and arteriovenous malformations, epilepsy surgery, and stereoelectroencephalography are a few examples. Contrast-enhanced cone-beam computed tomography (CE-CBCT) represents a powerful facility, since it is capable of acquiring images in the operation room, shortly before surgery...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27924730/congenital-malformations-attributed-to-prenatal-exposure-to-cyclophosphamide
#9
Padmanabhan Rengasamy
Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the growing trend among women postponing childbearing, the number of women who are diagnosed with breast cancer is also increasing thus escalating the chances of exposure of the unborn child to antineoplastic drugs...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27897152/a-novel-multi-frequency-electrical-impedance-tomography-spectral-imaging-algorithm-for-early-stroke-detection
#10
Lin Yang, Canhua Xu, Meng Dai, Feng Fu, Xuetao Shi, Xiuzhen Dong
Multi-frequency electrical impedance tomography (MFEIT) reconstructs the image of conductivity inside the human body based on the dependence of tissue conductivity on frequency. As there exist differences in the conductivity over frequency between blood, ischemic cortical tissue and normal cortical tissue, MFEIT has potential application in the detection of acute stroke. However, because the conductivity distribution of the human head is highly inhomogeneous and the conductivities of normal head tissue and stroke lesion tissue both change with frequency, the anomaly and normal head tissues are often mixed together in the reconstructed image, which makes it difficult to discern the anomaly...
December 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27896319/correlation-between-pollution-and-decline-of-scleractinian-cladocora-caespitosa-linnaeus-1758-in-the-gulf-of-gabes
#11
Akram El Kateb, Claudio Stalder, Christoph Neururer, Chiara Pisapia, Silvia Spezzaferri
During an expedition in 2014 in the Gulf of Gabes that aimed to evaluate the impact of the pollution of the phosphate industry on the marine environment, numerous dead coral fragments were retrieved from several stations along a 18 km long transect in front of the industry complex of Gabes. Detailed taxonomy of these coral fragments shows clearly that all fragments belong to the species Cladocora caespitosa (Linnaeus, 1758). Quantitative analysis of the coral fragments indicates a positive correlation with stations characterized by positive bathymetric anomalies...
November 2016: Heliyon
https://www.readbyqxmd.com/read/27895973/review-of-the-genetic-basis-of-jaw-malformations
#12
REVIEW
Mairaj K Ahmed, Xiaoqian Ye, Peter J Taub
Genetic etiologies for congenital anomalies of the facial skeleton, namely, the maxilla and mandible, are important to understand and recognize. Malocclusions occur when there exist any significant deviation from what is considered a normal relationship between the upper jaw (maxilla) and the lower jaw (mandible). They may be the result of anomalies of the teeth alone, the bones alone, or both. A number of genes play a role in the facial skeletal development and are regulated by a host of additional regulatory molecules...
December 2016: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/27895906/respiratory-distress-associated-with-heterotopic-gastrointestinal-cysts-of-the-oral-cavity-a-case-report
#13
Marco Antonio Méndez Sáenz, Mario de Jesús Villegas González, Marco A Ponce Camacho, Lucia M Cavazos Cavazos, Bárbara Sáenz Ibarra, Blanca I Esquivel García, José Luis Treviño González
Heterotopic gastrointestinal cysts of the oral cavity are benign lesions usually discovered during infancy. Their pathogenesis is not very clear. They are rare congenital anomalies that result from remnants of foregut-derived epithelium in the head, neck, thorax or abdomen during embryonic development. The majority of these lesions occur in the anterior ventral surface of the tongue and extend to the floor of the mouth. They are confused clinically by surgeons in cases of head and neck masses in children as ranulas, dermoid and thyroglossal cysts, and lymphangioma...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27895538/syndactyly-release
#14
REVIEW
Tara L Braun, Jeffrey G Trost, William C Pederson
Syndactyly is one of the most common congenital hand anomalies treated by pediatric plastic surgeons. Established principles of syndactyly separation dictate the timing and order of syndactyly release, with the goals of surgery being the creation of an anatomically normal webspace, tension-free closure of soft tissue, and return of function to the fingers. Numerous surgical methods have been described, many of which involve the use of local flaps to reconstruct the commissure and full-thickness skin grafts for coverage of raw areas...
November 2016: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/27894681/results-of-micronucleus-assays-with-individuals-who-are-occupationally-and-environmentally-exposed-to-mercury-lead-and-cadmium
#15
REVIEW
Armen Nersesyan, Michael Kundi, Monika Waldherr, Tahereh Setayesh, Miroslav Mišík, Georg Wultsch, Metka Filipic, Gustavo Rafael Mazzaron Barcelos, Siegfried Knasmueller
Millions of humans are exposed occupationally and environmentally to lead, mercury and cadmium compounds. Mercury compounds are less abundant but some of them belong to the most toxic chemicals which are known. We evaluated the literature to find out if these metals act in humans as genotoxic carcinogens and if their health effects can be predicted by use of micronucleus (MN) assays with lymphocytes and/or with other genotoxicity tests. Numerous studies showed that lead and mercury induce cancer in humans and also in animals, in vitro experiments with cultured cells indicate that they cause DNA damage via different molecular mechanisms including release of reactive oxygen species and interactions with DNA repair processes...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27891787/evaluation-of-the-western-australian-register-of-developmental-anomalies-thirty-five-years-of-surveillance
#16
Wendy N Nembhard, Carol Bower
BACKGROUND: The birth defects component of the Western Australian Register for Developmental Anomalies (WARDA-BD) was evaluated to assess its efficiency, effectiveness, and data quality. METHODS: WARDA-BD was evaluated using the Centers for Disease Control and Prevention Guidelines for Evaluating Public Health Surveillance Systems and Data Quality Standards from the National Birth Defects Prevention Network. The evaluation included interviews with Register staff, local community organizations, parents, clinicians, and researchers; process observation; and secondary data analyses...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27875174/screenit-visual-analysis-of-cellular-screens
#17
Kasper Dinkla, Hendrik Strobelt, Bryan Genest, Stephan Reiling, Mark Borowsky, Hanspeter Pfister
High-throughput and high-content screening enables large scale, cost-effective experiments in which cell cultures are exposed to a wide spectrum of drugs. The resulting multivariate data sets have a large but shallow hierarchical structure. The deepest level of this structure describes cells in terms of numeric features that are derived from image data. The subsequent level describes enveloping cell cultures in terms of imposed experiment conditions (exposure to drugs). We present Screenit, a visual analysis approach designed in close collaboration with screening experts...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27866998/tomographic-inversion-of-time-domain-resistivity-and-chargeability-data-for-the-investigation-of-landfills-using-a-priori-information
#18
Giorgio De Donno, Ettore Cardarelli
In this paper, we present a new code for the modelling and inversion of resistivity and chargeability data using a priori information to improve the accuracy of the reconstructed model for landfill. When a priori information is available in the study area, we can insert them by means of inequality constraints on the whole model or on a single layer or assigning weighting factors for enhancing anomalies elongated in the horizontal or vertical directions. However, when we have to face a multilayered scenario with numerous resistive to conductive transitions (the case of controlled landfills), the effective thickness of the layers can be biased...
January 2017: Waste Management
https://www.readbyqxmd.com/read/27863341/physical-constraints-on-the-non-dimensional-absorption-coefficients-of-compressional-and-shear-waves-for-viscoelastic-cylinders
#19
F G Mitri, Z E A Fellah
BACKGROUND: Normalized absorption coefficients for the longitudinal and shear waves in viscoelastic (polymer-type) materials, extracted from non-fictional experimental data showed anomalous effects, such as the generation of a negative radiation force (NRF) in plane progressive waves, negative energy absorption and extinction efficiencies and a scattering enhancement, not in agreement with energy conservation. OBJECTIVE: The objective of this work is directed towards analyzing those anomalies from the standpoint of energy conservation...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27834645/robust-detection-of-fast-and-slow-frequency-jumps-of-atomic-clocks
#20
Lorenzo Galleani, Patrizia Tavella
This paper presents a frequency jump detector for atomic clocks. The detector considers both fast frequency jumps, which are abrupt variations of the clock frequency trend, and slow frequency jumps, which correspond to variations of the frequency trend over a finite time interval. These anomalies are particularly critical for space clocks in global navigation satellite systems (GNSS). The developed detector is robust in the sense that it can deal with time-varying frequency trends, sinusoidal terms, outliers and missing data...
November 4, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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