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https://www.readbyqxmd.com/read/29475013/recommendations-for-the-successful-control-of-a-large-outbreak-of-vancomycin-resistant-enterococcus-faecium-vre-in-a-non-endemic-hospital-setting
#1
F N J Frakking, W S Bril, J C Sinnige, J E van 't Klooster, B A W de Jong, E J van Hannen, M Tersmette
BACKGROUND: A large outbreak of three epidemic vancomycin-resistant Enterococcus faecium (VRE) clones affected our hospital for almost two years. AIM: To describe the strategy to successfully control this outbreak and eradicate VRE from our hospital. METHODS: Infection control interventions started after detection of VRE in three patients. After ongoing transmission despite isolation precautions, cleaning and contact tracing, hospital-wide surveillance was started...
February 20, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29474882/the-angiographic-and-clinical-outcomes-of-intracranial-aneurysms-following-irradiation-in-patients-with-nasopharyngeal-carcinoma-a-13-year-experience-and-literature-review
#2
Chan Siang Hua Victor, Woo Yat Ming Peter, Wong Kai Sing Alain, Chan Kwong Yau, Leung Kar Ming
BACKGROUND AND PURPOSE: Intracranial aneurysms are a known but rare complication of radiotherapy (RT). We reviewed the angiographic and clinical outcomes of intracranial aneurysms following RT in patients with nasopharyngeal carcinoma (NPC), a malignancy endemic in Hong Kong. MATERIALS AND METHODS: The clinical, angiographic and laboratory data was collected for nine NPC patients harboring fifteen intracranial aneurysms following RT, diagnosed between 1st January 2000 and 31st December 2012...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474296/assessment-of-glaucomatous-damage-after-boston-keratoprosthesis-implantation-based-on-digital-planimetric-quantification-of-visual-fields-and-optic-nerve-head-imaging
#3
Mohsin H Ali, Mark S Dikopf, Anthony G Finder, Ahmad A Aref, Thasarat Vajaranant, Jose de la Cruz, Maria Soledad Cortina
PURPOSE: To investigate glaucomatous damage in Boston keratoprosthesis type I (KPro) patients through structural analysis of the optic nerve head and digital planimetric quantification of Goldmann visual fields, a novel method of monitoring perimetric changes in KPro patients. METHODS: Records of patients undergoing KPro implantation from 2007 to 2015 at a single institution were reviewed. Parameters related to glaucoma status and KPro outcomes were analyzed. RESULTS: Twenty-two eyes from 21 patients met inclusion criteria, with mean follow-up of 49...
February 22, 2018: Cornea
https://www.readbyqxmd.com/read/29474258/etiology-of-acute-otitis-media-and-characterization-of-pneumococcal-isolates-after-introduction-of-13-valent-pneumococcal-conjugate-vaccine-in-japanese-children
#4
Kimiko Ubukata, Miyuki Morozumi, Megumi Sakuma, Misako Takata, Eriko Mokuno, Takeshi Tajima, Satoshi Iwata
BACKGROUND: Acute otitis media (AOM) is a leading cause of childhood morbidity and antibiotic prescriptions. We examined etiologic changes in AOM after introduction of 13-valent pneumococcal conjugate vaccine as routine immunization for Japanese children in 2014. Serotypes, resistance genotypes, antibiotic susceptibilities, and multilocus sequence typing of pneumococcal isolates were also characterized. METHODS: Otolaryngologists prospectively collected middle ear fluid from 582 children by tympanocentesis or sampling through a spontaneously ruptured tympanic membrane between June 2016 and January 2017...
February 22, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29474240/high-rates-of-high-grade-cervical-dysplasia-in-high-risk-young-women-with-low-grade-cervical-cytology
#5
Laura R Daily, Britt K Erickson, Daniel N Pasko, J Michael Straughn, Warner K Huh, Charles A Leath
OBJECTIVE: The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology. MATERIALS AND METHODS: After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytology (atypical squamous cells of undetermined significance, high-risk human papillomavirus+, low-grade squamous intraepithelial lesion, or human papillomavirus+ only) managed with colposcopy at our university-based clinic between May 2011 and April 2013 were identified...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29474213/the-opioid-epidemic-and-the-current-prevalence-of-substance-use-disorder-in-anesthesiologists
#6
Ethan O Bryson
PURPOSE OF REVIEW: There has been a substantial increase in prescription and illicit opioid abuse in the general population observed over the last two decades. Initially fueled by an influx of prescription opioid medications, the opioid epidemic now includes increasingly potent heroin and illicit fentanyl. Younger anesthesiologists, those currently in training or recent graduates, have come of age in a society where opioid abuse is much more prevalent. RECENT FINDINGS: The current prevalence of substance use disorder (SUD) in the physician population is slightly higher than in the general population and appears to be increasing...
February 22, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29474173/possibility-of-database-research-as-a-means-of-pharmacovigilance-in-japan-based-on-a-comparison-with-sertraline-postmarketing-surveillance
#7
Yoko Hirano, Yuko Asami, Kazuhiko Kuribayashi, Shigeru Kitazaki, Yuji Yamamoto, Yoko Fujimoto
BACKGROUND: Many pharmacoepidemiologic studies using large-scale databases have recently been utilized to evaluate the safety and effectiveness of drugs in Western countries. In Japan, however, conventional methodology has been applied to postmarketing surveillance (PMS) to collect safety and effectiveness information on new drugs to meet regulatory requirements. Conventional PMS entails enormous costs and resources despite being an uncontrolled observational study method. This study is aimed at examining the possibility of database research as a more efficient pharmacovigilance approach by comparing a health care claims database and PMS with regard to the characteristics and safety profiles of sertraline-prescribed patients...
June 20, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29474141/robot-assisted-retroperitoneal-lymphadenectomy-in-testicular-cancer-treatment-a-systematic-review
#8
Aggelos Tselos, Demetrios Moris, Diamantis I Tsilimigras, Evangelos Fragkiadis, Eustratia Mpaili, Panagiotis Sakarellos, Michail Vailas, Kevin N Shah, Alexandros Papalampros
INTRODUCTION: Retroperitoneal lymph node dissection (RPLND) in testicular cancer is a documented treatment along with active surveillance and chemotherapy. This study aims to summarize the current evidence on the use of Robot-assisted RPLND (RARPLND) in comparison with the laparoscopic and open approach. MATERIALS AND METHODS: A search was conducted in the existing literature focusing on reports with outcomes of RARPLND for stage I-IIB testicular tumor. RESULTS: Eleven studies complied with the inclusion criteria, including 116 patients...
February 23, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29473992/radical-prostatectomy-and-the-effect-of-close-surgical-margins-results-from-the-search-database
#9
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
https://www.readbyqxmd.com/read/29473903/the-role-of-culex-pipiens-l-diptera-culicidae-in-virus-transmission-in-europe
#10
REVIEW
Victor A Brugman, Luis M Hernández-Triana, Jolyon M Medlock, Anthony R Fooks, Simon Carpenter, Nicholas Johnson
Over the past three decades, a range of mosquito-borne viruses that threaten public and veterinary health have emerged or re-emerged in Europe. Mosquito surveillance activities have highlighted the Culex pipiens species complex as being critical for the maintenance of a number of these viruses. This species complex contains morphologically similar forms that exhibit variation in phenotypes that can influence the probability of virus transmission. Critical amongst these is the choice of host on which to feed, with different forms showing different feeding preferences...
February 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29473896/congenital-toxoplasmosis-a-plea-for-a-neglected-disease
#11
Martine Wallon, François Peyron
Maternal infection by Toxoplasma gondii during pregnancy may have serious consequences for the fetus, ranging from miscarriage, central nervous system involvement, retinochoroiditis, or subclinical infection at birth with a risk of late onset of ocular diseases. As infection in pregnant women is usually symptomless, the diagnosis relies only on serological tests. Some countries like France and Austria have organized a regular serological testing of pregnant women, some others have no prenatal program of surveillance...
February 23, 2018: Pathogens
https://www.readbyqxmd.com/read/29473512/the-role-of-inflammatory-response-in-stroke-associated-programmed-cell-death
#12
K Duris, Z Splichal, M Jurajda
Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation...
February 22, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29473482/prospective-surveillance-and-targeted-physiotherapy-for-arm-morbidity-after-breast-cancer-surgery-a-pilot-randomized-controlled-trial
#13
Bolette S Rafn, Stanley Hung, Alison M Hoens, Margaret L McNeely, Chiara A Singh, Winkle Kwan, Carol Dingee, Elaine C McKevitt, Urve Kuusk, Jinsi Pao, Nancy Van Laeken, Charlie H Goldsmith, Kristin L Campbell
OBJECTIVE: To evaluate prospective surveillance and targeted physiotherapy (PSTP) compared to education (EDU) on the prevalence of arm morbidity and describe the associated program cost. DESIGN: Pilot randomized single-blinded controlled trial. SETTING: Urban with assessments and treatment delivered in hospitals. PARTICIPANTS: Women scheduled for breast cancer surgery. INTERVENTIONS: Participants were randomly assigned (1:1) to PSTP ( n = 21) or EDU ( n = 20) and assessed presurgery and 12 months postsurgery...
February 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29473406/plaidoyer-pour-un-renforcement-du-syst%C3%A3-me-de-pharmacovigilance-au-burkina-faso
#14
Lassané Kaboré, Téné Marceline Yaméogo, Issiaka Sombié, Moussa Ouédraogo, Souleymane Fofana, Abdramane Berthé, Rasmané Semdé, Fati Kirakoya-Samadoulougou
Large-scale deployment of new medicines has been observed over the last two decades in many Sub-Saharan Africa countries faced with major public health issues such as malaria and HIV/AIDS. However, some of these medicines may be responsible for varying degrees of toxicity, with adverse drug reactions leading to decreased compliance or even discontinuation of treatment. Pharmacovigilance systems therefore had to be set up in these countries, such as in Burkina Faso, West Africa, which initiated the organization of pharmacovigilance activities in 2008...
January 30, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29473402/-introduction-many-countries-have-developed-disease-surveillance-systems-to-deal-with-epidemics-but-although-health-information-systems-have-existed-for-more-than-two-decades-constraints-and-biases-in-data-collection-limit-the-relevance-of-policy-decisions
#15
Fatoumata Hane
INTRODUCTION: Many countries have developed disease surveillance systems to deal with epidemics, but although health information systems have existed for more than two decades, constraints and biases in data collection limit the relevance of policy decisions and strategies in the field of health, as priority has been given to education and health in developing countries. Donor support has led to the development of systems for the production of statistics, designed, among other things, to more clearly target interventions in terms of educational objectives, action and credibility and enable health systems to continue to benefit from external funding...
January 30, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29473394/-introduction-heavy-rainfall-in-may-2016-caused-large-scale-flooding-of-the-seine-and-its-tributaries-analysis-of-this-unusual-event-showed-that-it-could-recur-on-an-even-larger-scale-the-sanitary-consequences-were-less-frequently-assessed-in-this-analysis
#16
Laurène Dufayet, Chantal Médernach, Clément Bassi, Robert Garnier, Jérôme Langrand
INTRODUCTION: Heavy rainfall in May 2016 caused large-scale flooding of the Seine and its tributaries. Analysis of this unusual event showed that it could recur on an even larger scale. The sanitary consequences were less frequently assessed in this analysis, particularly the risk of accidental collective carbon monoxide (CO) poisoning caused by the use of combustion engine drainage pumps. METHODS: We retrospectively reviewed all cases of acute accidental carbon monoxide exposure observed in the Ile-de-France region, related to the use of drainage pumps in spring and summer 2016 and notified to the Ile-de-France CO poisoning surveillance network...
January 30, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29473333/risk-factors-and-survival-outcomes-in-patients-with-breast-cancer-and-lung-metastasis-a-population-based-study
#17
Weikai Xiao, Shaoquan Zheng, Peng Liu, Yutian Zou, Xinhua Xie, Ping Yu, Hailin Tang, Xiaoming Xie
The risk factors for morbidity and mortality in breast cancer lung metastases (BCLM) patients still remain poorly identified. The aim of this study was to assess the incidence and survival of BCLM and associated risk factors. Patients with BCLM were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate logistic regression analysis was used to determine the risk factors for BCLM. Predictors of factors associated with death were analyzed in Cox regression and Fine and Gray's test...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473322/a-method-to-identify-the-areas-at-risk-for-the-introduction-of-avian-influenza-virus-into-poultry-flocks-through-direct-contact-with-wild-ducks
#18
G Galletti, A Santi, V Guberti, G Paternoster, E Licata, L Loli Piccolomini, A Procopio, M Tamba
Wild dabbling ducks are the main reservoir for avian influenza (AI) viruses and pose an ongoing threat to commercial poultry flocks. Combining the (i) size of that population, (ii) their flight distances and (iii) their AI prevalence, the density of AI-infected dabbling ducks (DID) was calculated as a risk factor for the introduction of AI viruses into poultry holdings of Emilia-Romagna region, Northern Italy. Data on 747 poultry holdings and on 39 AI primary outbreaks notified in Emilia-Romagna between 2000 and 2017 were used to validate that risk factor...
February 22, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29473136/factors-that-influence-parental-misperception-of-their-child-s-actual-weight-status-in-south-carolina
#19
Dana M AlHasan, Charity B Breneman, Chelsea L Lynes, Kate Callahan-Myrick
Objectives Studies suggest that parents tend to misperceive their child's actual weight status and typically underestimate their child's weight. Since few studies examine the factors that influence parental misperception, this study aims to assess the influence of parent and child factors with parental misperception of their child's actual weight status who were either at their recommended weight or overweight/obese in South Carolina in 2013 and 2014. Methods Secondary data were obtained from the Behavioral Risk Factor Surveillance System (BRFSS) and the Children's Health Assessment Survey (CHAS) in 2013 and 2014 in SC...
February 22, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29472902/prevention-and-control-strategies-to-counter-zika-virus-a-special-focus-on-intervention-approaches-against-vector-mosquitoes-current-updates
#20
REVIEW
Raj K Singh, Kuldeep Dhama, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Ruchi Tiwari, Sandip Chakraborty, Yashpal S Malik, Rubén Bueno-Marí
Zika virus (ZIKV) is the most recent intruder that acquired the status of global threat creating panic and frightening situation to public owing to its rapid spread, attaining higher virulence and causing complex clinical manifestations including microcephaly in newborns and Guillain Barré Syndrome. Alike other flaviviruses, the principal mode of ZIKV transmission is by mosquitoes. Advances in research have provided reliable diagnostics for detecting ZIKV infection, while several drug/therapeutic targets and vaccine candidates have been identified recently...
2018: Frontiers in Microbiology
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