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Physical activity prostatic cancer

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https://www.readbyqxmd.com/read/29158832/clinical-translation-and-first-in-human-use-of-44-sc-sc-psma-617-for-pet-imaging-of-metastasized-castrate-resistant-prostate-cancer
#1
Elisabeth Eppard, Ana de la Fuente, Martina Benešová, Ambreen Khawar, Ralph A Bundschuh, Florian C Gärtner, Barbara Kreppel, Klaus Kopka, Markus Essler, Frank Rösch
BACKGROUND: Various trivalent radiometals are well suited for labeling of DOTA-conjugated variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The DOTA-conjugate PSMA-617 has proven high potential in PSMA radioligand therapy (PSMA-RLT) of prostate cancer as well as PET imaging when labeled with lutetium-177 and gallium-68 respectively. Considering the relatively short physical half-life of gallium-68 this positron emitter precludes prolonged acquisition periods, as required for pre-therapeutic dosimetry or intraoperative applications...
2017: Theranostics
https://www.readbyqxmd.com/read/29143545/taz-responds-to-fluid-shear-stress-to-regulate-the-cell-cycle
#2
Hyun Jung Lee, Adesuwa Ewere, Miguel F Diaz, Pamela L Wenzel
Physical forces associated with tumor growth and drainage alter cancer cell invasiveness and metastatic potential. We previously showed that fluid frictional force, or shear stress, typical of lymphatic flow induces YAP1/TAZ activation in prostate cancer cells to promote motility dependent upon YAP1 but not TAZ. Here, we show that shear stress elevates TAZ protein levels and promotes TAZ nuclear localization. Increased TAZ activity drives increased DNA synthesis and induces AMOTL2, ANKRD1, and CTGF gene transcription independently of YAP1...
November 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29112317/-prostate-cancer-is-far-more-hidden%C3%A2-perceptions-of-stigma-social-isolation-and-help-seeking-among-men-with-prostate-cancer
#3
K A Ettridge, J A Bowden, S K Chambers, D P Smith, M Murphy, S M Evans, D Roder, C L Miller
The purpose of this study was to provide in-depth insight into men's experiences of prostate cancer, specifically: perceived stigma and self-blame, social isolation, unmet need and help-seeking. A qualitative descriptive approach was used. Semi-structured interviews were undertaken with 20 men diagnosed with prostate cancer, and thematic analysis was undertaken. Some participants perceived a stigma associated with prostate cancer and cancer in general, which sometimes acted as a barrier to disclosure. Self-blame and internalisation of cause was not a prominent issue...
November 7, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29094773/availability-of-prostate-cancer-exercise-rehabilitation-resources-and-practice-patterns-in-belgium-results-of-a-cross-sectional-study
#4
R Bultijnck, B Van Ruymbeke, S Everaert, H Bagué, E Rammant, S Rimbaut, V Fonteyne, N Lumen, K Decaestecker, P Ost
Exercise is recommended for prostate cancer (PCa) patients treated with androgen deprivation therapy. The goal of the study was to assess the availability of hospital-based rehabilitation resources and national practice patterns for PCa in Belgium. A questionnaire was conducted with rehabilitation physical therapists in all Belgian hospital with urology and rehabilitation departments. Practice patterns were compared with the American College of Sports Medicine guidelines. PCa prevalence data were obtained from the Belgian Cancer Registry and attitude of physicians towards physical activity was documented...
November 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29049045/nutrition-physical-activity-and-lifestyle-factors-in-prostate-cancer-prevention
#5
Eric Ballon-Landa, John Kellogg Parsons
PURPOSE OF REVIEW: To review current evidence for prostate cancer prevention with nutrition, physical activity, and lifestyle interventions and identify future research directions. RECENT FINDINGS: Multiple preclinical and observational studies have observed that diet, exercise, and lifestyle interventions may play a role in mitigating disease progression, mortality, and overall disease burden for high-grade and fatal prostate cancer. Increased vegetable and fruit intakes, decreased red meat and saturated fat intakes, and increased exercise are potentially associated with decreased risk of incident disease and increased progression-free, prostate cancer-specific, and overall survival...
October 18, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29038181/barriers-and-facilitators-to-healthy-lifestyle-and-acceptability-of-a-dietary-and-physical-activity-intervention-among-african-caribbean-prostate-cancer-survivors-in-the-uk-a-qualitative-study
#6
Vanessa Er, J Athene Lane, Richard M Martin, Raj Persad, Frank Chinegwundoh, Victoria Njoku, Eileen Sutton
OBJECTIVES: Diet and lifestyle may have a role in delaying prostate cancer progression, but little is known about the health behaviours of Black British prostate cancer survivors despite this group having a higher prostate cancer mortality rate than their White counterparts. We explored the barriers and facilitators to dietary and lifestyle changes and the acceptability of a diet and physical activity intervention in African Caribbean prostate cancer survivors. DESIGN: We conducted semistructured in-depth interviews and used thematic analysis to code and group the data...
October 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29017509/acceptability-of-dietary-and-physical-activity-lifestyle-modification-for-men-following-radiotherapy-or-radical-prostatectomy-for-localised-prostate-cancer-a-qualitative-investigation
#7
Lucy E Hackshaw-McGeagh, Eileen Sutton, Raj Persad, Jonathan Aning, Amit Bahl, Anthony Koupparis, Chris Millett, Richard M Martin, J Athene Lane
BACKGROUND: The experience and acceptability of lifestyle interventions for men with localised prostate cancer are not well understood, yet lifestyle interventions are increasingly promoted for cancer survivors. We explored the opinions, experiences and perceived acceptability of taking part in nutritional and physical activity interventions amongst men with prostate cancer and their partners; with the ultimate plan to use such information to inform the development of nutritional and physical activity interventions for men with prostate cancer...
October 10, 2017: BMC Urology
https://www.readbyqxmd.com/read/28978344/the-expect-examining-exercise-prostate-cancer-and-circulating-tumour-cells-trial-study-protocol-for-a-randomised-controlled-trial
#8
Gráinne Sheill, Lauren Brady, Emer Guinan, Brian Hayes, Orla Casey, John Greene, Tatjana Vlajnic, Fidelma Cahill, Mieke Van Hemelrijck, Nicola Peat, Sarah Rudman, Juliette Hussey, Moya Cunningham, Liam Grogan, Thomas Lynch, Rustom P Manecksha, John McCaffrey, Lorelei Mucci, Orla Sheils, John O'Leary, Dearbhaile M O'Donnell, Ray McDermott, Stephen Finn
BACKGROUND: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population...
October 4, 2017: Trials
https://www.readbyqxmd.com/read/28976393/-approach-to-peripheral-arterial-disease-in-the-elderly
#9
Ozan Onur Balkanay, Suat Nail Ömeroğlu
The prevalence of peripheral arterial disease, which usually develops on the basis of atherosclerosis and develops as a result of chronic arterial occlusive pathology, increases with age. Peripheral artery disease in the elderly patient population may be asymptomatic due to restrictive conditions associated with immobilization. Concurrent cerebrovascular disease and coronary artery disease risk and mortality rates are higher in elderly patients with peripheral artery disease. The life expectancy in patients with peripheral arterial disease is worse than in prostate cancer patients...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28969358/possible-role-of-diet-in-cancer-systematic-review-and-multiple-meta-analyses-of-dietary-patterns-lifestyle-factors-and-cancer-risk
#10
Giuseppe Grosso, Francesca Bella, Justyna Godos, Salvatore Sciacca, Daniele Del Rio, Sumantra Ray, Fabio Galvano, Edward L Giovannucci
Context: Evidence of an association between dietary patterns derived a posteriori and risk of cancer has not been reviewed comprehensively. Objective: The aim of this review was to investigate the relation between a posteriori-derived dietary patterns, grouped as healthy or unhealthy, and cancer risk. The relation between cancer risk and background characteristics associated with adherence to dietary patterns was also examined. Data Sources: PubMed and Embase electronic databases were searched...
June 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28929838/the-influence-of-nutritional-factors-on-prostate-cancer-incidence-and-aggressiveness
#11
Manrique Pascual-Geler, Noelia Urquiza-Salvat, Jose Manuel Cozar, Inmaculada Robles-Fernandez, Ana Rivas, Luis Javier Martinez-Gonzalez, Francisco Manuel Ocaña-Peinado, Jose Antonio Lorente, Maria Jesus Alvarez-Cubero
There is an increasing evidence for a link between nutrition, lifestyle and prostate cancer (PCa) development and/or progression of disease. The objective of this study was to examine the association between dietary factors and PCa incidence and aggressiveness in a case-control study. After the analysis of the anatomic pathology, subjects were classified in patients with PCa (n = 157) and controls (n = 158). Clinical data including Gleason score, PSA values and biopsy results, were compiled. Frequencies of food consumption and sociodemographic data were also obtained...
September 20, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28891033/targeted-alpha-therapy-of-mcrpc-dosimetry-estimate-of-213-bismuth-psma-617
#12
Clemens Kratochwil, Karl Schmidt, Ali Afshar-Oromieh, Frank Bruchertseifer, Hendrik Rathke, Alfred Morgenstern, Uwe Haberkorn, Frederik L Giesel
PURPOSE: PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA). In this work, we estimate the radiation dosimetry for this ligand labeled with the alpha-emitter (213)Bi. METHODS: Three patients with metastatic prostate cancer underwent PET scans 0.1 h, 1 h, 2 h, 3 h, 4 h and 5 h after injection of (68)Ga-PSMA-617. Source organs were kidneys, liver, spleen, salivary glands, bladder, red marrow and representative tumor lesions...
September 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28881355/presurgical-weight-loss-affects-tumour-traits-and-circulating-biomarkers-in-men-with-prostate-cancer
#13
RANDOMIZED CONTROLLED TRIAL
Wendy Demark-Wahnefried, Soroush Rais-Bahrami, Renee A Desmond, Jennifer B Gordetsky, Gary R Hunter, Eddy S Yang, Maria Azrad, Andrew D Frugé, Yuko Tsuruta, Lyse A Norian, Roanne Segal, William E Grizzle
BACKGROUND: Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer. METHODS: This single-blinded, two-arm randomised controlled trial explored outcomes of a presurgical weight loss intervention (WLI) that promoted ∼1 kg per week loss via caloric restriction and increased physical activity (PA)...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28872752/time-on-androgen-deprivation-therapy-and-adaptations-to-exercise-secondary-analysis-from-a-12-month-randomized-controlled-trial-in-men-with-prostate-cancer
#14
Dennis R Taaffe, Laurien M Buffart, Robert U Newton, Nigel Spry, James Denham, David Joseph, David Lamb, Suzanne K Chambers, Daniel A Galvão
OBJECTIVES: To explore if duration of prior exposure to androgen deprivation therapy (ADT) in men with prostate cancer (PCa) undertaking a yearlong exercise program moderates the exercise response on body composition and muscle performance. In addition, we explored the moderator effect of baseline testosterone, time since ADT, and baseline value of the outcome. PATIENTS AND METHODS: In a multicenter randomized controlled trial, 100 patients previously treated for either 6 months (short-term) or 18 months (long-term) ADT in combination with radiotherapy as part of the TROG 03...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28871558/examining-the-accessibility-of-high-quality-physical-activity-behaviour-change-support-freely-available-online-for-men-with-prostate-cancer
#15
Camille E Short, Charlotte Gelder, Lena Binnewerg, Megan McIntosh, Deborah Turnbull
BACKGROUND: While the internet is considered a promising avenue for providing physical activity support to prostate cancer survivors, little is known about the accessibility of quality websites in the real world. PURPOSE: This work aimed to explore what websites prostate cancer survivors are likely to find when seeking physical activity support online and to evaluate their quality using evidenced-based criteria. METHOD: A search strategy was developed in consultation with prostate cancer survivors (n = 44) to reflect the most common ways they are likely to search the internet...
September 4, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28866631/association-of-gender-specific-risk-factors-in-metabolic-and-cardiovascular-diseases-an-nhanes-based-cross-sectional-study
#16
Xiu-E Zhang, Bei Cheng, Qian Wang, Jing-Jing Wan
In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007-2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42...
September 2, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28859204/-physical-activity-and-cancer
#17
Stephanie Krebs, Anika Berling-Ernst, Martin Halle
The value of physical activity in cancer prevention and therapy has been increasingly recognised during the last twenty years. Many patients suffer from a loss of physical performance and a decline in quality of life - with fatigue, anxiety and depression as a direct result of their disease and therapy. Since the 1990 s, there has been a substantial increase in scientific evidence demonstrating the positive effects of physical activity in cancer patients. This article presents an overview of the most important studies investigating the effects of physical activity for breast, colon, and prostate cancer...
August 31, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28854891/cancer-related-risk-factors-and-incidence-of-major-cancers-by-race-gender-and-region-analysis-of-the-nih-aarp-diet-and-health-study
#18
Tomi Akinyemiju, Howard Wiener, Maria Pisu
BACKGROUND: Racial disparities in the incidence of major cancers may be attributed to differences in the prevalence of established, modifiable risk factors such as obesity, smoking, physical activity and diet. METHODS: Data from a prospective cohort of 566,398 adults aged 50-71 years, 19,677 African-American and 450,623 Whites, was analyzed. Baseline data on cancer-related risk factors such as smoking, alcohol, physical activity and dietary patterns were used to create an individual adherence score...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28835353/a-web-based-and-print-based-computer-tailored-physical-activity-intervention-for-prostate-and-colorectal-cancer-survivors-a-comparison-of-user-characteristics-and-intervention-use
#19
Rianne Henrica Johanna Golsteijn, Catherine Bolman, Denise Astrid Peels, Esmee Volders, Hein de Vries, Lilian Lechner
BACKGROUND: Physical activity (PA) is beneficial in improving negative physical and psychological effects of cancer. The rapidly increasing number of cancer survivors, resulting from aging and improved cancer care, emphasizes the importance to develop and provide low cost, easy accessible PA programs. Such programs could be provided through the Internet, but that could result in the exclusion of cancer survivors not familiar with the Internet. Therefore, we developed a computer-tailored PA intervention for prostate and colorectal cancer survivors in which both Web-based and print materials are provided, and participants can choose their own preferred delivery mode...
August 23, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28826701/outcomes-of-men-on-active-surveillance-for-low-risk-prostate-cancer-at-a-safety-net-hospital
#20
E Charles Osterberg, Nynikka R A Palmer, Catherine R Harris, Gregory P Murphy, Sarah D Blaschko, Carissa Chu, Isabel E Allen, Matthew R Cooperberg, Peter R Carroll, Benjamin N Breyer
PURPOSE: To characterize demographic, disease, and cancer outcomes of men on active surveillance (AS) at a safety-net hospital and characterize those who were lost to follow-up (LTFU). METHODS: From January 2004 to November 2014, 104 men with low-risk prostate cancer (PCa) were followed with AS at Zuckerberg San Francisco General Hospital (ZSFG). Criteria for AS have evolved over time; however, patients with diagnostic prostate-specific antigen (PSA) 10ng/mL or less, clinical stage T1/2, biopsy Gleason score 3 + 3 or 3 + 4, 33% or fewer positive cores, and 50% or less tumor in any single core were potentially eligible for AS...
November 2017: Urologic Oncology
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