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https://www.readbyqxmd.com/read/27888214/cardiorespiratory-fitness-and-death-from-cancer-a-42-year-follow-up-from-the-copenhagen-male-study
#1
Magnus Thorsten Jensen, Andreas Holtermann, Hans Bay, Finn Gyntelberg
OBJECTIVES: Poor cardiorespiratory fitness (CRF) is associated with death from cancer. If follow-up time is short, this association may be confounded by subclinical disease already present at the time of CRF assessment. This study investigates the association between CRF and death from cancer and any cause with 42 years and 44 years of follow-up, respectively. SETTING, PARTICIPANTS AND MAIN OUTCOME MEASURES: Middle-aged, employed and cancer-free Danish men from the prospective Copenhagen Male Study, enrolled in 1970-1971, were included...
November 25, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27886411/dog-ownership-and-physical-activity-among-breast-prostate-and-colorectal-cancer-survivors
#2
Cynthia C Forbes, Chris M Blanchard, W Kerry Mummery, Kerry S Courneya
BACKGROUND: Dog ownership has been associated with higher rates of physical activity (PA) in several populations but no study to date has focused on cancer survivors. The purpose of this study was to examine the associations between dog ownership and PA among cancer survivors; and to examine correlates of dog ownership. METHODS: A stratified random sample of 2062 breast (BCS), prostate (PCS), and colorectal cancer survivors (CRCS) was mailed a questionnaire assessing PA, social-cognitive, dog ownership, demographic, and medical variables...
November 25, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27884704/enhanced-aggressiveness-of-bystander-cells-in-an-anti-tumor-photodynamic-therapy-model-role-of-nitric-oxide-produced-by-targeted-cells
#3
Jerzy Bazak, Jonathan M Fahey, Katarzyna Wawak, Witold Korytowski, Albert W Girotti
The bystander effects of anti-cancer ionizing radiation have been widely studied, but far less is known about such effects in the case of non-ionizing photodynamic therapy (PDT). In the present study, we tested the hypothesis that photodynamically-stressed prostate cancer PC3 cells can elicit nitric oxide (NO)-mediated pro-growth/migration responses in non-stressed bystander cells. A novel approach was used whereby both cell populations existed on a culture dish, but made no physical contact with one other...
November 22, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27884071/a-pilot-study-on-the-motivational-effects-of-an-internet-delivered-physical-activity-behaviour-change-programme-in-nova-scotian-cancer-survivors
#4
Cynthia C Forbes, Chris M Blanchard, W Kerry Mummery, Kerry S Courneya
OBJECTIVE: To examine the effects of an internet-delivered, distance-based physical activity (PA) behaviour change programme on motivation to perform PA in cancer survivors. DESIGN: Breast, prostate and colorectal cancer survivors (N = 95) were randomized to either an online Theory of Planned Behaviour (TPB)-based PA behaviour change programme (UCAN) or usual care. MAIN OUTCOME MEASURES: Motivational variables from the TPB including intention, planning, attitude, subjective norm, perceived behavioural control and underlying beliefs...
November 24, 2016: Psychology & Health
https://www.readbyqxmd.com/read/27881518/study-protocol-for-a-randomised-controlled-trial-of-brief-habit-based-lifestyle-advice-for-cancer-survivors-exploring-behavioural-outcomes-for-the-advancing-survivorship-cancer-outcomes-trial-ascot
#5
Rebecca J Beeken, Helen Croker, Maggie Heinrich, Lee Smith, Kate Williams, Allan Hackshaw, John Hines, Michael Machesney, Madhavan Krishnaswamy, Sharon Cavanagh, Rebecca Roylance, Alison Hill, Kathy Pritchard-Jones, Jane Wardle, Abigail Fisher
INTRODUCTION: Positive health behaviours such as regular physical activity and a healthy diet have significant effects on cancer outcomes. There is a need for simple but effective behaviour change interventions with the potential to be implemented within the cancer care pathway. Habit-based advice encourages repetition of a behaviour in a consistent context so that the behaviour becomes increasingly automatic in response to a specific contextual cue. This approach therefore encourages long-term behaviour change and can be delivered through printed materials...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27871956/evidence-for-masturbation-and-prostate-cancer-risk-do-we-have-a-verdict
#6
REVIEW
Basil H Aboul-Enein, Joshua Bernstein, Michael W Ross
INTRODUCTION: Prostate cancer (PCa) is one of the leading causes of cancer death in men and remains one of the most diagnosed malignancies worldwide. Ongoing public health efforts continue to promote protective factors, such as diet, physical activity, and other lifestyle modifications, against PCa development. Masturbation is a nearly universal safe sexual activity that transcends societal boundaries and geography yet continues to be met with stigma and controversy in contemporary society...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27861848/gamma-glutamyltransferase-and-risk-of-prostate-cancer-findings-from-the-kihd-prospective-cohort-study
#7
Setor K Kunutsor, Jari A Laukkanen
Increased circulating serum gamma-glutamyltransferase (GGT) has been linked with an increased risk of chronic disease outcomes, including overall and several site-specific cancers. However, the relationship of GGT with prostate cancer risk is uncertain. We aimed to assess the prospective association of GGT with risk of prostate cancer. Serum GGT activity was assessed at baseline in the Finnish Kuopio Ischemic Heart Disease prospective cohort of 2,390 men aged 42-61 years without a history of cancer at baseline...
November 8, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27844337/physical-activity-and-prostate-cancer-an-updated-review
#8
REVIEW
Roy J Shephard
Prostate cancer affects a major proportion of older men, and effective preventive measures are few. Earlier suggestions of 10-30% risk reduction from vigorous physical activity thus merit further analysis. This narrative review updates information on associations between physical activity and prostate cancer, seeking activity patterns associated with maximal risk reduction. Systematic searches of Ovid/MEDLINE and PubMed databases from 1996 to June 2016 have linked the terms prostate neoplasms/prostate cancer with occupation, occupational title, sedentary job or heavy work, exercise, physical activity, sports, athletes, physical education/training or aerobic fitness...
November 14, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27843346/the-danish-prostate-cancer-database
#9
REVIEW
Mary Nguyen-Nielsen, Søren Høyer, Søren Friis, Steinbjørn Hansen, Klaus Brasso, Erik Breth Jakobsen, Mette Moe, Heidi Larsson, Mette Søgaard, Anne Nakano, Michael Borre
AIM OF DATABASE: The Danish Prostate Cancer Database (DAPROCAdata) is a nationwide clinical cancer database that has prospectively collected data on patients with incident prostate cancer in Denmark since February 2010. The overall aim of the DAPROCAdata is to improve the quality of prostate cancer care in Denmark by systematically collecting key clinical variables for the purposes of health care monitoring, quality improvement, and research. STUDY POPULATION: All Danish patients with histologically verified prostate cancer are included in the DAPROCAdata...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27837443/do-cancer-survivors-develop-healthier-lifestyle-behaviors-than-the-cancer-free-population-in-the-plco-study
#10
Makenzie L Hawkins, Saundra S Buys, Lisa H Gren, Sara E Simonsen, Anne C Kirchhoff, Mia Hashibe
BACKGROUND: Current studies report mixed results in health status and health behaviors after a diagnosis of cancer. The aim of our study is to investigate potential differences in lifestyle factors among cancer survivors and cancer-free individuals in a prospective cohort study conducted in the United States. METHODS: Using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Trial, 10,133 cancer survivors were identified and compared to 81,992 participants without cancer to evaluate differences in body mass index (BMI), smoking, NSAID use, and physical activity...
November 11, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27816833/diet-body-size-physical-activity%C3%A2-and-risk-of-prostate-cancer-an-umbrella-review-of-the-evidence
#11
REVIEW
Georgios Markozannes, Ioanna Tzoulaki, Dimitra Karli, Evangelos Evangelou, Evangelia Ntzani, Marc J Gunter, Teresa Norat, John P Ioannidis, Konstantinos K Tsilidis
The existing literature on the relationship between diet, body size, physical activity and prostate cancer risk was summarised by the World Cancer Research Fund Continuous Update Project (CUP). An evaluation of the robustness of this evidence is required to help inform public health policy. The robustness of this evidence was evaluated using several criteria addressing evidence strength and validity, including the statistical significance of the random effects summary estimate and of the largest study in a meta-analysis, number of prostate cancer cases, between-study heterogeneity, 95% prediction intervals, small-study effects bias, excess significance bias and sensitivity analyses with credibility ceilings...
November 3, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27771244/a-study-of-combination-bicalutamide-and-raloxifene-for-patients-with-castration-resistant-prostate-cancer
#12
Thai H Ho, Rafael Nunez-Nateras, Yue-Xian Hou, Alan H Bryce, Donald W Northfelt, Amylou C Dueck, Bryan Wong, Melissa L Stanton, Richard W Joseph, Erik P Castle
BACKGROUND: Prostate tissue expresses 2 estrogen receptor (ER) isoforms, ER-α and ER-β, and estrogen-based therapies have shown activity in preclinical studies. Raloxifene, a selective ER modulator, has inhibited the growth of prostate cancer xenograft models and was tested in a phase II trial of castration-resistant prostate cancer (CRPC), with some patients achieving stable disease. However, no studies have examined the safety of the combination of bicalutamide plus raloxifene for CRPC...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27753182/quality-of-life-outcomes-from-the-prostate-adenocarcinoma-transcutaneous-hormones-patch-trial-evaluating-luteinising-hormone-releasing-hormone-agonists-versus-transdermal-oestradiol-for-androgen-suppression-in-advanced-prostate-cancer
#13
Duncan C Gilbert, Trinh Duong, Howard G Kynaston, Abdulla A Alhasso, Fay H Cafferty, Stuart D Rosen, Subramanian Kanaga-Sundaram, Sanjay Dixit, Marc Laniado, Sanjeev Madaan, Gerald Collins, Alvan Pope, Andrew Welland, Matthew Nankivell, Richard Wassersug, Mahesh K B Parmar, Ruth E Langley, Paul D Abel
OBJECTIVES: To compare quality-of-life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol (tE2) or luteinising hormone-releasing hormone agonists (LHRHa) for androgen-deprivation therapy (ADT). PATIENTS AND METHODS: Men with locally advanced or metastatic prostate cancer participating in an ongoing randomised, multicentre UK trial comparing tE2 versus LHRHa for ADT were enrolled into a QoL sub-study. tE2 was delivered via three or four transcutaneous patches containing oestradiol 100 μg/24 h...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27749527/variations-of-physical-activity-and-sedentary-behavior-between-before-and-after-cancer-diagnosis-results-from-the-prospective-population-based-nutrinet-sant%C3%A3-cohort
#14
Philippine Fassier, Laurent Zelek, Valentin Partula, Bernard Srour, Patrick Bachmann, Marina Touillaud, Nathalie Druesne-Pecollo, Pilar Galan, Patrice Cohen, Hélène Hoarau, Paule Latino-Martel, Mehdi Menai, Jean-Michel Oppert, Serge Hercberg, Mélanie Deschasaux, Mathilde Touvier
Physical activity (PA) but also reduced sedentary behavior may be associated with better prognosis and lower risk of recurrence in cancer patients. Our aim was to quantify the variations in PA and time spent sedentary between before and after diagnosis, relying on prospective data in French adults. We also investigated sociodemographic and lifestyle factors associated with these variations.Subjects (n = 942) were incident cancer cases diagnosed in the NutriNet-Santé cohort between 2009 and 2015. PA and sedentary behavior were prospectively collected with the 7-day short version of the IPAQ questionnaire every year since subjects' inclusion (i...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27726215/factors-associated-with-current-and-severe-physical-side-effects-after-prostate-cancer-treatment-what-men-report
#15
L Steentjes, S Siesling, F J Drummond, J G van Manen, L Sharp, A Gavin
We identified patient and disease characteristics associated with (1) "current" physical side-effects of any severity; and (2) "severe" physical side-effects "ever" experienced by 3,348 (54%) prostate cancer (PCa) survivors in Ireland diagnosed 2-18 years previously. Postal questionnaires collected symptoms at diagnosis, post-biopsy complications, comorbidities, primary treatments and physical side-effects post-treatment (urinary incontinence, erectile dysfunction, libido loss, bowel problems, breast changes, hot flushes, and fatigue, "ever" and "current" at time of questionnaire completion)...
October 10, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27720532/setting-an-agenda-for-assessment-of-health-related-quality-of-life-among-men-with-prostate-cancer-on-active-surveillance-a-consensus-paper-from-a-european-school-of-oncology-task-force
#16
Silvia Villa, Friederike Kendel, Lionne Venderbos, Tiziana Rancati, Chris Bangma, Peter Carroll, Louis Denis, Laurence Klotz, Ida J Korfage, Athene J Lane, Tiziana Magnani, Ken Mastris, Antti Rannikko, Monique Roobol, Bruce Trock, Roderick Van den Bergh, Hendrik Van Poppel, Riccardo Valdagni, Lara Bellardita
BACKGROUND: Literature on the health-related quality of life (HRQoL) for men with localized prostate cancer (PCa) on active surveillance (AS) shows a need for methodological guidance regarding HRQoL issues and how to address them. OBJECTIVE: The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies. DESIGN, SETTING, AND PARTICIPANTS: A modified Delphi study was used to reach consensus on AS HRQoL research topics and tools between 2014 and 2015...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27716218/effectiveness-of-community-based-football-compared-to-usual-care-in-men-with-prostate-cancer-protocol-for-a-randomised-controlled-parallel-group-multicenter-superiority-trial-the-fc-prostate-community-trial
#17
Eik Bjerre, Ditte Marie Bruun, Anders Tolver, Klaus Brasso, Peter Krustrup, Christoffer Johansen, Robin Christensen, Mikael Rørth, Julie Midtgaard
BACKGROUND: Prostate cancer is the most common non-cutaneous malignancy in men. Today most patients may expect to live years following the diagnosis and may thus experience significant morbidity due to disease progression and treatment toxicity. In order to address some of these problems exercise has been suggested and previously studies have shown improvements of disease specific quality of life and a reduction in treatment-related toxicity. Cohort studies with long term follow up have suggested that physical activity is associated with improved survival in prostate cancer patients...
October 3, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27699825/elevated-c-peptides-abdominal-obesity-and-abnormal-adipokine-profile-are-associated-with-higher-gleason-scores-in-prostate-cancer
#18
Katie M Di Sebastiano, Jehonathan H Pinthus, Wilhelmina C M Duivenvoorden, Laurel Patterson, Joel A Dubin, Marina Mourtzakis
BACKGROUND: Prostate cancer development is associated with numerous lifestyle factors (i.e., physical activity, nutrition intake) and metabolic perturbations. These factors have been studied independently; here, we used an integrative approach to characterize these lifestyle and metabolic parameters in men undergoing diagnostic prostate biopsies. METHODS: We prospectively evaluated 51 consecutive men for body composition, metabolic factors including glucose- and lipid-related measures, as well as lifestyle factors prior to prostate biopsy...
October 4, 2016: Prostate
https://www.readbyqxmd.com/read/27677728/associations-of-post-diagnosis-physical-activity-and-change-from-pre-diagnosis-physical-activity-with-quality-of-life-in-prostate-cancer-survivors
#19
Megan S Farris, Karen A Kopciuk, Kerry S Courneya, Elizabeth McGregor, Qinggang Wang, Christine M Friedenreich
BACKGROUND: This prospective study examined the associations between post-diagnosis physical activity and change from pre-diagnosis physical activity with quality of life (QoL) in prostate cancer survivors. METHODS: Prostate cancer survivors (n=830) who participated in a case-control study with invasive stage {greater than or equal to}II disease were followed up to 2007 to capture QoL outcomes. At baseline and three time points post-diagnosis (2000-2007), interviews/questionnaires were used to collect data on physical activity, general QoL measured by the SF-36 and other treatment/lifestyle factors...
September 27, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27650933/management-of-prostate-cancer-patients-with-locally-adverse-pathologic-features-after-radical-prostatectomy-feasibility-of-active-surveillance-for-cases-with-gleason-grade-3%C3%A2-%C3%A2-4%C3%A2-%C3%A2-7
#20
Xun Shangguan, Baijun Dong, Yanqing Wang, Fan Xu, Xiaoguang Shao, Jianjun Sha, Yinjie Zhu, Jiahua Pan, Wei Xue
PURPOSE: To evaluate the ability of the new Gleason grade groups (GGGs) to stratify risk in prostate cancer patients with locally adverse pathologic features after radical prostatectomy (RP) thereby allowing more accurate assessment for planning eventual adjuvant therapy. PATIENTS AND METHODS: Data on 172 patients with locally adverse pathologic features (including seminal vesicle invasion, extracapsular extension, or positive surgical margins) who had been treated with wait and see policy after RP were retrospectively analyzed for biochemical recurrence (BCR)-free survival...
September 20, 2016: Journal of Cancer Research and Clinical Oncology
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