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Physical activity prostatic cancer

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https://www.readbyqxmd.com/read/28808043/allosteric-alterations-in-the-androgen-receptor-and-activity-in-prostate-cancer
#1
REVIEW
Takuma Uo, Stephen R Plymate, Cynthia C Sprenger
Organisms have evolved to generate biological complexity in their proteome and transcriptome from a limited number of genes. This concept holds true for the androgen receptor, which displays a diversity of inclusion/exclusion events in its structural motifs as a mechanism of resistance to the most forefront anti-androgen therapies. More than 20 androgen receptor variants that lack various portions of ligand-binding domain have been identified in human prostate cancer (PCa) samples. Most of the variants are inactive on their own, with a few exceptions displaying constitutive activity...
September 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28795218/atopy-and-prostate-cancer-is-there-a-link-between-circulating-levels-of-ige-and-psa-in-humans
#2
Mieke Van Hemelrijck, Sophia N Karagiannis, Sabine Rohrmann
BACKGROUND: Atopy has been investigated as a potential risk factor for prostate cancer. IgE antibodies may be major players in protective responses against tumours, through engendering antigen presentation and enhancing adaptive immune responses targeted towards a specific allergen, but potentially also against tumour-associated antigens such as prostate-specific antigen (PSA). We therefore cross-sectionally investigated associations between circulating levels of PSA and IgE in the National Health and Nutrition Examination Survey 2005-2006...
August 9, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28781209/why-epidemiological-studies-of-physical-activity-in-prostate-cancer-often-underestimate-its-benefits
#3
EDITORIAL
Mary Kathryn Downer
No abstract text is available yet for this article.
August 3, 2017: European Urology
https://www.readbyqxmd.com/read/28775317/interaction-between-von-hippel-lindau-protein-and-fatty-acid-synthase-modulates-hypoxia-target-gene-expression
#4
Wendi Sun, Hiroyuki Kato, Shojiro Kitajima, Kian Leong Lee, Katarina Gradin, Takashi Okamoto, Lorenz Poelllinger
Hypoxia-inducible factors (HIFs) play a central role in the transcriptional response to changes in oxygen availability. Stability of HIFs is regulated by multi-step reactions including recognition by the von Hippel-Lindau tumour suppressor protein (pVHL) in association with an E3 ligase complex. Here we show that pVHL physically interacts with fatty acid synthase (FASN), displacing the E3 ubiquitin ligase complex. This results in HIF-α protein stabilization and activation of HIF target genes even in normoxia such as during adipocyte differentiation...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28760403/health-related-quality-of-life-for-immediate-versus-delayed-androgen-deprivation-therapy-in-patients-with-asymptomatic-non-curable-prostate-cancer-trog-03-06-and-vcog-pr-01-03-toad-a-randomised-multicentre-non-blinded-phase-3-trial
#5
Gillian M Duchesne, Henry H Woo, Madeleine King, Steven J Bowe, Martin R Stockler, Alice Ames, Catherine D'Este, Mark Frydenberg, Andrew Loblaw, Shawn Malone, Jeremy Millar, Keen Hun Tai, Sandra Turner
BACKGROUND: Androgen-deprivation therapy in patients with prostate cancer who have relapsed with rising prostate-specific antigen concentration only (PSA-only relapse), or with non-curable but asymptomatic disease at diagnosis, could adversely affect quality of life at a time when the disease itself does not. We aimed to compare the effect of immediate versus delayed androgen-deprivation therapy on health-related quality of life over 5 years in men enrolled in the TOAD (Timing of Androgen Deprivation) trial...
July 28, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28749619/healthy-plant-foods-intake-could-protect-against-prostate-cancer-risk-a-case-control-study
#6
Yahya Jalilpiran, Erfan Hezaveh, Salmeh Bahmanpour, Shiva Faghih
Background: Several studies have investigated the association between healthy plant foods intake and prostate cancer risk with inconsistent results. So this study was conducted to examine the existence of any possible association between healthy plant foods and prostate cancer risk. Materials and Methods: Sixty newly diagnosed prostate cancer cases and 60 controls engaged in a hospital-based case-control study. A validated 16o-items semi-quantitative FFQ was used to assess usual dietary intakes. Energy-adjusted amounts of healthy plant foods intake were calculated using the residual method...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28731882/the-effect-on-bone-outcomes-of-home-based-exercise-intervention-for-prostate-cancer-survivors-receiving-androgen-deprivation-therapy-a-pilot-randomized-controlled-trial
#7
Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Young Deuk Choi, Eunju Choi, Youngkyu Song, Hosook Song
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25)...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#8
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
July 14, 2017: Urologia
https://www.readbyqxmd.com/read/28723724/coping-strategies-used-by-breast-prostate-and-colorectal-cancer-survivors-a-literature-review
#9
Mari P Lashbrook, Patricia C Valery, Vikki Knott, Marilynne N Kirshbaum, Christina M Bernardes
BACKGROUND: Individual coping strategies are a fundamental element underpinning psychosocial distress. OBJECTIVE: The aim of this study was to describe coping strategies and their measurement used by survivors of breast, prostate, and/or colorectal cancer after treatment. METHODS: A search of electronic databases (PubMed, CINAHL, and PsycINFO) was conducted from January 1980 to March 2015. Data were extracted using standardized forms and included studies that explored the coping mechanisms of survivorship of breast, prostate, or colorectal cancer...
July 14, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28711382/recreational-physical-activity-in-relation-to-prostate-cancer-specific-mortality-among-men-with-nonmetastatic-prostate-cancer
#10
Ying Wang, Eric J Jacobs, Susan M Gapstur, Maret L Maliniak, Ted Gansler, Marjorie L McCullough, Victoria L Stevens, Alpa V Patel
BACKGROUND: Large prospective cohort studies need to confirm the associations between recreational physical activity (PA), including the most common type-walking, and prostate cancer-specific mortality (PCSM) among prostate cancer patients. OBJECTIVE: To investigate the associations of recreational PA, reported before and after diagnosis, with PCSM, overall and by tumor risk category. DESIGN, SETTING, AND PARTICIPANTS: In a prospective cohort study conducted in the USA, men diagnosed with nonmetastatic prostate cancer between 1992/1993 and June 2011 were followed for mortality until 2012...
July 12, 2017: European Urology
https://www.readbyqxmd.com/read/28707842/leisure-time-physical-activity-and-risk-of-prostate-cancer-a-dose-response-meta-analysis
#11
Feng Liu, Jing Wang, Hai-Long Wu, Hui Wang, Jian-Xiang Wang, Rui Zhou, Zhi Zhu
INTRODUCTION: Physical activity (PA) may be a protect factor against prostate cancer (Pca). We aim to investigate and establish the potential relationship between leisure-time PA and Pca. EVIDENCE ACQUISITION: PubMed, Embase databases were searched for eligibly studies (cohort) before Aug-11, 2016. We conducted a meta-analysis to pool the dose-specific effects between leisure-time PA and Pca. Subgroup analysis was employed to see the potential variation among each group...
July 12, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28698340/leisure-time-physical-activity-and-circulating-25-hydroxyvitamin-d-levels-in-cancer-survivors-a-cross-sectional-analysis-using-data-from-the-us-national-health-and-nutrition-examination-survey
#12
Lin Yang, Adetunji T Toriola
OBJECTIVES: Circulating 25-hydroxyvitamin D (25-OHD) is associated with improved cancer prognosis in some studies, yet it may be a surrogate marker for physical activity. We investigated the associations of leisure-time physical activity (LTPA) with circulating 25-OHD levels in cancer survivors, and determined whether associations differ by indoor and outdoor activity. DESIGN: Cross-sectional study. SETTING: The US National Health and Nutrition Examination Survey (NHANES)...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28685892/randomized-controlled-trial-of-a-peer-led-multimodal-intervention-for-men-with-prostate-cancer-to-increase-exercise-participation
#13
Daniel A Galvão, Robert U Newton, Afaf Girgis, Stephen J Lepore, Anna Stiller, Cathrine Mihalopoulos, Robert A Gardiner, Dennis R Taaffe, Stefano Occhipinti, Suzanne K Chambers
OBJECTIVE: Exercise may reduce morbidity, increase survival, and improve quality of life (QoL) in prostate cancer patients. However, effective ways to encourage exercise outside carefully controlled clinical trials remain uncertain. We evaluated the effectiveness of peer-led self-management for increasing exercise participation in men with localized prostate cancer. METHODS: Four hundred and sixty-three prostate cancer patients from Queensland, Australia were randomized to a monthly telephone-based group peer support for 6 months supported by self-management materials and exercise equipment (INT, n = 232) or usual care (UC, n = 231)...
July 7, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28656468/the-role-of-the-built-environment-in-a-randomized-controlled-trial-to-increase-physical-activity-among-men-with-prostate-cancer-the-promote-trial
#14
Erin L McGowan, Daniel Fuller, Nicoleta Cutumisu, Scott North, Kerry S Courneya
PURPOSE: The purpose of the study was to examine the association between the built environment and physical activity (PA) in prostate cancer survivors (PCS), as well as whether built environment factors (walkability, count of sports complexes) were effect modifiers of a PA intervention. METHODS: Our study included 165 PCS residing in Edmonton, Alberta, from the PROMOTE trial. The PROMOTE trial was a randomized controlled trial of a behaviour change intervention to increase PA and quality of life in PCS...
June 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28651586/development-of-a-computer-tailored-physical-activity-intervention-for-prostate-and-colorectal-cancer-patients-and-survivors-oncoactive
#15
R H J Golsteijn, C Bolman, E Volders, D A Peels, H de Vries, L Lechner
BACKGROUND: Cancer and cancer treatment coincide with substantial negative physical, psychological and psychosocial problems. Physical activity (PA) can positively affect the negative effects of cancer and cancer treatment and thereby increase quality of life in CPS. Nevertheless, only a minority of CPS meet PA guidelines. We developed the OncoActive (OncoActief in Dutch) intervention: a computer-tailored PA program to stimulate PA in prostate and colorectal CPS, because to our knowledge there are only a few PA interventions for these specific cancer types in the Netherlands METHODS: The OncoActive intervention was developed through systematic adaptation of a proven effective, evidence-based, computer-tailored PA intervention for adults over fifty, called Active Plus...
June 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28646365/post-diagnosis-serum-insulin-like-growth-factors-in-relation-to-dietary-and-lifestyle-changes-in-the-prostate-testing-for-cancer-and-treatment-protect-trial
#16
Vanessa Er, Kalina Biernacka, Andrew J Simpkin, Richard M Martin, Mona Jeffreys, Pauline Emmett, Rebecca Gilbert, Kerry N L Avery, Eleanor Walsh, Michael Davis, Jenny L Donovan, David E Neal, Freddie C Hamdy, Jeff M P Holly, J Athene Lane
PURPOSE: The insulin-like growth factor (IGF) system is modifiable by diet and lifestyle, and has been linked to prostate cancer development and progression. METHODS: We conducted a prospective cohort study of 621 men diagnosed with localized prostate cancer to investigate the associations of dietary and lifestyle changes with post-diagnosis circulating levels of IGF-I and IGFBP-3. We used analysis of covariance to estimate the associations, controlling for baseline IGF-I or IGFBP-3, respectively...
August 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28636526/does-health-coaching-grow-capacity-in-cancer-survivors-a-systematic-review
#17
Suzette Barakat, Kasey Boehmer, Marwan Abdelrahim, Sangwoo Ahn, Abdulrahman A Al-Khateeb, Neri Álvarez Villalobos, Larry Prokop, Patricia J Erwin, Kirsten Fleming, Valentina Serrano, Gabriela Spencer-Bonilla, Mohammad Hassan Murad
Interventions that grow patient capacity to do the work of health care and life are needed to support the health of cancer survivors. Health coaching may grow capacity. This systematic review of health coaching interventions explored coaching's ability to grow capacity of cancer survivors. The authors included randomized trials or quasi-experimental studies comparing coaching to alternative interventions, and adhered to PRISMA reporting guidelines. Data were analyzed using the Theory of Patient Capacity (BREWS: Capacity is affected by factors that influence ability to reframe Biography ["B"], mobilize or recruit Resources ["R"], interact with the Environment of care ["E"], accomplish Work ["W"]), and function Socially ["S"])...
June 21, 2017: Population Health Management
https://www.readbyqxmd.com/read/28632242/exploring-gender-differences-in-self-reported-physical-activity-and-health-among-older-caregivers
#18
Colleen A Cuthbert, Kathryn King-Shier, Dianne Tapp, Dean Ruether, S Nicole Culos-Reed
PURPOSE/OBJECTIVES: To document self-reported physical health and activity levels of older caregivers. Gender differences in physical health, physical activity levels, and predictors of physical activity were also examined.
. DESIGN: A cross-sectional study.
. SETTING: Tom Baker Cancer Centre in Calgary, Alberta, Canada.
. SAMPLE: 130 caregivers aged 60 years or older caring for individuals with breast, prostate, or colorectal cancer...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28621209/habits-and-self-assessed-quality-of-life-negative-intrusive-thoughts-and-depressed-mood-in-patients-with-prostate-cancer-a-longitudinal-study
#19
David Bock, Eva Angenete, Anders Bjartell, Stefan Carlsson, Gunnar Steineck, Johan Stranne, Thordis Thorsteinsdottir, Peter Wiklund, Eva Haglind
OBJECTIVE: The aim of this study was to evaluate the association of self-assessed preoperative physical activity, alcohol consumption and smoking with self-assessed quality of life, negative intrusive thoughts and depressed mood after radical prostatectomy. MATERIALS AND METHODS: The Laparoscopic Prostatectomy Robot Open (LAPPRO) trial was a prospective, controlled, non-randomized longitudinal trial of patients (n = 4003) undergoing radical prostatectomy at 14 centers in Sweden...
June 16, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28620703/epidemiology-and-biology-of-physical-activity-and-cancer-recurrence
#20
REVIEW
Christine M Friedenreich, Eileen Shaw, Heather K Neilson, Darren R Brenner
Physical activity is emerging from epidemiologic research as a lifestyle factor that may improve survival from colorectal, breast, and prostate cancers. However, there is considerably less evidence relating physical activity to cancer recurrence and the biologic mechanisms underlying this association remain unclear. Cancer patients are surviving longer than ever before, and fear of cancer recurrence is an important concern. Herein, we provide an overview of the current epidemiologic evidence relating physical activity to cancer recurrence...
June 15, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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