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https://www.readbyqxmd.com/read/29770953/a-systematic-review-of-physical-activity-based-behaviour-change-interventions-reaching-men-with-prostate-cancer
#1
REVIEW
A Finlay, G Wittert, C E Short
PURPOSE: Men who are survivors of prostate cancer report a variety of psychological and physical factors contributing to a lower quality of life, and physical activity can assist to mitigate these issues. This review aims to provide a summary of physical activity behaviour change trials targeting prostate cancer survivors, assess the feasibility of these interventions and, if possible, identify intervention and study characteristics associated with significant intervention effects. METHOD: Four databases (PubMed, CINAHL, PsycINFO and EMBASE) were systematically searched for randomised controlled trials containing at least one behavioural outcome relating to physical activity published up until July 2016...
May 16, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29764892/intense-exercise-for-survival-among-men-with-metastatic-castrate-resistant-prostate-cancer-interval-gap4-a-multicentre-randomised-controlled-phase-iii-study-protocol
#2
Robert U Newton, Stacey A Kenfield, Nicolas H Hart, June M Chan, Kerry S Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A Galvão, Charles J Ryan, Fred Saad
INTRODUCTION: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC). METHODS AND ANALYSIS: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29712628/a-web-based-intervention-to-reduce-distress-after-prostate-cancer-treatment-development-and-feasibility-of-the-getting-down-to-coping-program-in-two-different-clinical-settings
#3
Jane Cockle-Hearne, Deborah Barnett, James Hicks, Mhairi Simpson, Isabel White, Sara Faithfull
BACKGROUND: Distress after prostate cancer treatment is a substantial burden for up to one-third of men diagnosed. Physical and emotional symptoms and health service use can intensify, yet men are reticent to accept support. To provide accessible support that can be cost effectively integrated into care pathways, we developed a unique, Web-based, self-guided, cognitive-behavior program incorporating filmed and interactive peer support. OBJECTIVE: To assess feasibility of the intervention among men experiencing distress after prostate cancer treatment...
April 30, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29696211/characteristics-of-cancer-patients-participating-in-presurgical-lifestyle-intervention-trials-exploring-effects-on-tumor-biology
#4
John A Dasher, Andrew D Frugé, Denise C Snyder, Wendy Demark-Wahnefried
Background: Poor diet and insufficient physical activity are strongly associated with an increased risk of several cancers. Preclinical studies suggest that lifestyle modifications may exert favorable effects on tumor biology. Randomized controlled trials in the presurgical setting serve as an ideal means to translate this research to humans; however, little is known about the characteristics of patients who enroll in these presurgical trials versus those who do not. Methods: Screening databases from three presurgical lifestyle intervention trials for breast and prostate cancer patients conducted at Duke University Medical Center (NCT00049309) and the University of Alabama at Birmingham (NCT02224807 and NCT01886677) were combined for analysis...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29651945/modeling-of-a-cyclotron-target-for-the-production-of-11c-with-geant4
#5
Andrea Chiappiniello, Federico Zagni, Angelo Infantino, Sara Vichi, Gianfranco Cicoria, Maria Pia Morigi, Mario Marengo
BACKGROUND: In medical cyclotron facilities, 11C is produced according to the 14N(p,α)11C reaction and widely employed in studies of prostate and brain cancers by Positron Emission Tomography. It is known from literature [1] that the 11C-target assembly shows a reduction in efficiency during time, meaning a decrease of activity produced at the end of bombardment. This effect might depend on aspects still not completely known. OBJECTIVE: Possible causes of the loss of performance of the 11C-target assembly were addressed by Monte Carlo simulations...
April 12, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29651647/an-estrogen-related-lifestyle-score-is-associated-with-risk-of-postmenopausal-breast-cancer-in-the-plco-cohort
#6
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
PURPOSE: Healthy or unhealthy lifestyle behaviors are often adopted together. We aimed to investigate the combined effect of estrogen-related lifestyle factors on postmenopausal breast cancer risk. METHODS: Data from 27,153 women enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were used. We created an estrogen-related lifestyle score (ERLS) by incorporating a previously developed measure of estrogenic diet, alcohol intake, body mass index (BMI), and physical activity...
April 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29645327/exploring-cancer-survivors-views-of-health-behavior-change-where-do-you-start-where-do-you-stop-with-everything
#7
Teresa Corbett, Tara Cheetham, Andre Matthias Müller, Joanna Slodkowska-Barabasz, Laura Wilde, Adele Krusche, Alison Richardson, Claire Foster, Eila Watson, Paul Little, Lucy Yardley, Katherine Bradbury
OBJECTIVE: Physical activity (PA) and a healthy diet can improve the well-being of cancer survivors. However, cancer survivors often do not engage in these behaviours. This study aimed to explore barriers and facilitators to engaging in these behaviours following cancer treatment. METHODS: During the development of a web-based intervention to enhance health-related quality of life in cancer survivors, 32 people who had completed treatment for breast, colon or prostate cancer were presented with an intervention for PA and healthy eating...
April 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29596883/antagonistic-activities-of-mir-148a-and-dnmt1-ectopic-expression-of-mir-148a-impairs-dnmt1-mrna-and-dwindle-cell-proliferation-and-survival
#8
Dipta Sengupta, Moonmoon Deb, Samir Kumar Patra
Functional analyses of noncoding RNAs have associated many micro RNAs (miRNA, miR) with various physiological processes, including proliferation, differentiation, development, cell metabolism, and apoptosis. Aberrant expression of miRNA and imbalance in their functions may lead to cellular aberration and different disease development, including cancer. In silico analysis of miRNA target prediction suggested that miR-148a possess a binding site in the 3' UTR of DNMT1 mRNA which can cause silencing of DNMT1 gene...
March 26, 2018: Gene
https://www.readbyqxmd.com/read/29593021/lifestyle-advice-to-cancer-survivors-a-qualitative-study-on-the-perspectives-of-health-professionals
#9
Dimitrios A Koutoukidis, Sonia Lopes, Abigail Fisher, Kate Williams, Helen Croker, Rebecca J Beeken
OBJECTIVES: Adoption of healthy lifestyle behaviours has shown promising effectiveness in reducing the high morbidity burden of cancer survivors. Health professionals (HPs) are well suited to provide lifestyle advice but few survivors report receiving guidance from them. This study aimed to explore HPs' perspective of lifestyle advice (on healthy eating, physical activity, smoking, and alcohol) for cancer survivors. DESIGN: In-depth semistructured qualitative interviews were conducted by telephone or face to face...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29576530/latest-evidence-on-the-impact-of-smoking-sports-and-sexual-activity-as-modifiable-lifestyle-risk-factors-for-prostate-cancer-incidence-recurrence-and-progression-a-systematic-review-of-the-literature-by-the-european-association-of-urology-section-of-oncological
#10
REVIEW
Sabine D Brookman-May, Riccardo Campi, Jose D S Henríquez, Tobias Klatte, Johan F Langenhuijsen, Maurizio Brausi, Estefania Linares-Espinós, Alessandro Volpe, Martin Marszalek, Bulent Akdogan, Christina Roll, Christian G Stief, Oscar Rodriguez-Faba, Andrea Minervini
CONTEXT: Smoking, sexual activity, and physical activity (PA) are discussed as modifiable lifestyle factors associated with prostate cancer (PCa) development and progression. OBJECTIVE: To evaluate the available evidence concerning the association of smoking, sexual activity, and sports and exercise on PCa risk, treatment outcome, progression, and cancer-specific mortality. EVIDENCE ACQUISITION: A systematic review of studies published between 2007 and 2017 using MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials, and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement criteria was conducted...
March 22, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29572229/the-mda-9-syntenin-igf-1r-stat3-axis-directs-prostate-cancer-invasion
#11
Swadesh K Das, Anjan K Pradhan, Praveen Bhoopathi, Sarmistha Talukdar, Xue-Ning Shen, Devanand Sarkar, Luni Emdad, Paul B Fisher
Although prostate cancer (PCa) is clinically manageable during several stages of progression, survival is severely compromised once cells invade and metastasize to distant organs. Comprehending the pathobiology of invasion is required for developing efficacious targeted therapies against metastasis. Based on bioinformatics data, we predicted an association of melanoma differentiation associated gene-9 (syntenin, or syndecan binding protein (SDCBP)) in PCa progression. Using tissue samples from various Gleason stage PCa patients with adjacent normal tissue, a series of normal prostate and PCa cell lines (with differing tumorigenic/metastatic properties), mda-9/syntenin manipulated variants (including loss-of-function and gain-of-function cell lines), and CRISPR/Cas9 stable MDA-9/syntenin knockout cells, we now confirm the relevance of and dependence on MDA-9/syntenin in PCa invasion...
March 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29569731/exercise-and-prostate-cancer-from-basic-science-to-clinical-applications
#12
REVIEW
Christian Campos, Paula Sotomayor, Daniel Jerez, Javier González, Camila B Schmidt, Katharina Schmidt, Winfried Banzer, Alejandro S Godoy
Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment...
March 23, 2018: Prostate
https://www.readbyqxmd.com/read/29564692/a-systematic-review-of-pfe-pre-prostatectomy
#13
REVIEW
S S Goonewardene, D Gillatt, R Persad
Male Stress Urinary Incontinence is a complication post robotic radical prostatectomy. This is a major problem that needs to be solved, since it has great impact on quality of life affecting the patient's physical activity and social well-being. A systematic review relating to literature on impact of preoperative PFE on continence outcomes for patients undergoing prostatectomy was conducted. The search strategy aimed to identify all references related to pelvic floor exercises and post-prostatectomy. Search terms used were as follows: (Pelvic floor exercises) AND (incontinence) AND (prostatectomy)...
March 21, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29560520/changes-in-the-levels-of-testosterone-profile-over-time-in-relation-to-clinical-parameters-in-a-cohort-of-patients-with-prostate-cancer-managed-by-active-surveillance
#14
Ahmed S Zakaria, Alice Dragomir, Wassim Kassouf, Simon Tanguay, Armen Aprikian
OBJECTIVES: To characterize testosterone profile changes over time in a cohort of prostate cancer (PCa) patients managed with active surveillance (AS) and to assess its correlation with the initial disease characteristics and further progression. METHODS: We conducted retrospective chart review of PCa patients managed with AS. Patients were followed with PSA, total, free and bioavailable testosterone measurements, physical examination, and by repeat biopsies or periodic magnetic resonance imaging...
March 20, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29559731/first-degree-relatives-of-cancer-patients-a-target-group-for-primary-prevention-a-cross-sectional-study
#15
Ulrike Haug, Oliver Riedel, Constanze Cholmakow-Bodechtel, Louise Olsson
BACKGROUND: Persons with a first-degree relative (FDR) with cancer are at increased cancer risk. We investigated preventive behaviour, cancer risk perception and readiness to change an unhealthy lifestyle in persons with and without an FDR with cancer. METHODS: Using an online questionnaire, we conducted a cross-sectional study in Germany including persons (≥35 years) with an FDR with colorectal, lung, prostate, breast, stomach or cervical/uterine cancer (n = 621) and persons without cancer in FDRs (n = 303)...
March 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29551549/return-to-work-following-robot-assisted-laparoscopic-and-open-retropubic-radical-prostatectomy-a-single-center-cohort-study-to-compare-duration-of-sick-leave
#16
Stefanie von Mechow, Markus Graefen, Alexander Haese, Pierre Tennstedt, Dirk Pehrke, Frank Friedersdorff, Burkhard Beyer
PURPOSE: To compare the duration of sick leave in patients with localized prostate cancer after robot-assisted radical prostatectomy (RARP) and open retropubic RP (ORP) at a German high-volume prostate cancer center. METHODS: The data of 1,415 patients treated with RP at Martini Klinik, Prostate Cancer Center between 2012 and 2016 were, retrospectively, analyzed. Information on employment status, monthly revenues and days of work missed due to sickness were assessed via online questionnaire...
June 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29548365/multiparametric-mp-mri-of-prostate-cancer
#17
REVIEW
Virendra Kumar, Girdhar S Bora, Rajeev Kumar, Naranamangalam R Jagannathan
Prostate cancer (PCa) is one of the most prevalent cancers in men. A large number of men are detected with PCa; however, the clinical behavior ranges from low-grade indolent tumors that never develop into a clinically significant disease to aggressive, invasive tumors that may rapidly progress to metastatic disease. The challenges in clinical management of PCa are at levels of screening, diagnosis, treatment, and follow-up after treatment. Magnetic resonance imaging (MRI) methods have shown a potential role in detection, localization, staging, assessment of aggressiveness, targeting biopsies, etc...
April 2018: Progress in Nuclear Magnetic Resonance Spectroscopy
https://www.readbyqxmd.com/read/29527464/physical-activity-and-annual-medical-outlay-in-u-s-colorectal-breast-and-prostate-cancer-survivors
#18
Alice F Yan, Yang Wang, Alexander V Ng
Multiple chronic conditions in cancer survivors are highly prevalent and may increase health care costs for both patients and the health care system. Studies of cancer survivors reveal positive effects of physical activity (PA) on reducing risk of cancer recurrence, other chronic conditions, and secondary cancer. Few nationally representative studies have examined how physical activity levels have affected survivors' annual economic burden in the United States. Leisure-time physical activity data from the National Health Interview Survey was linked to health care expenditure data from the Medical Expenditure Panel Survey data (2008-2012)...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29506297/-exercise-and-physical-activity-during-and-after-cancer-who-benefits-most-what-is-proven
#19
Karen Steindorf, Martina E Schmidt, Philipp Zimmer
A growing number of literature reports positive effects of physical activity and exercise. These effects concern prevention, mortality and progress of cancer. Furthermore they show a reduction of disease- and treatment-specific side effects, which implies a better patients' quality of life. Evidence shows a decreased mortality risk in patients with physically active cancer of colon, breast, ovaries and prostate. Activity recommendations for patients with cancer do not differ from those for healthy persons...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29489050/urinary-bowel-and-sexual-health-in-older-men-from-northern-ireland
#20
David W Donnelly, Conan Donnelly, Therese Kearney, David Weller, Linda Sharp, Amy Downing, Sarah Wilding, Penny Wright, Paul Kind, James W F Catto, William R Cross, Malcolm D Mason, Eilis McCaughan, Richard Wagland, Eila Watson, Rebecca Mottram, Majorie Allen, Hugh Butcher, Luke Hounsome, Peter Selby, Dyfed Huws, David H Brewster, Emma McNair, Carol Rivas, Johana Nayoan, Mike Horton, Lauren Matheson, Adam W Glaser, Anna Gavin
OBJECTIVES: To provide data on the prevalence of urinary, bowel and sexual dysfunction in Northern Ireland (NI), to act as a baseline for studies of prostate cancer outcomes and to aid service provision within the general population. SUBJECTS AND METHODS: A cross-sectional postal survey of 10 000 men aged ≥40 years in NI was conducted and age-matched to the distribution of men living with prostate cancer. The EuroQoL five Dimensions five Levels (EQ-5D-5L) and 26-item Expanded Prostate Cancer Composite (EPIC-26) instruments were used to enable comparisons with prostate cancer outcome studies...
February 28, 2018: BJU International
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