keyword
https://read.qxmd.com/read/31577095/nutraceutical-treatment-and-prevention-of-benign-prostatic-hyperplasia-and-prostate-cancer
#21
REVIEW
Arrigo F G Cicero, Olta Allkanjari, Gian Maria Busetto, Tommaso Cai, Gaetano Larganà, Vittorio Magri, Gianpaolo Perletti, Francesco Saverio Robustelli Della Cuna, Giorgio Ivan Russo, Kostantinos Stamatiou, Alberto Trinchieri, Annabella Vitalone
During the last years, pharmaceutical innovations in primary care are dramatically less frequent and will be even more rare in the next future. In this context, preclinical and clinical research oriented their interest toward natural compounds efficacy and safety, supporting the development of a new "nutraceutical" science. Medicinal plants, in the form of plant parts or extracts of them, are commonly used for the treatment of prostate diseases such as benign hypertrophy, prostatitis and chronic pelvic pain syndrome...
October 2, 2019: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/31540470/plant-bioactives-and-the-prevention-of-prostate-cancer-evidence-from-human-studies
#22
REVIEW
Tracey L Livingstone, Gemma Beasy, Robert D Mills, Jenny Plumb, Paul W Needs, Richard Mithen, Maria H Traka
Prostate cancer has become the most common form of non-cutaneous (internal) malignancy in men, accounting for 26% of all new male visceral cancer cases in the UK. The aetiology and pathogenesis of prostate cancer are not understood, but given the age-adjusted geographical variations in prostate cancer incidence quoted in epidemiological studies, there is increasing interest in nutrition as a relevant factor. In particular, foods rich in phytochemicals have been proposed to reduce the risk of prostate cancer...
September 18, 2019: Nutrients
https://read.qxmd.com/read/31449274/fatty-acids-in-some-cooking-oils-as-agents-of-hormonal-manipulation-in-a-rat-model-of-benign-prostate-cancer
#23
JOURNAL ARTICLE
O Oyelowo, C Okafor, A Ajibare, B Ayomide, K Dada, R Adelakun, B Ahmed
Anti-androgenic substances, mainly prostate 5α-reductase inhibitors, used in the treatment of benign prostatic hyperplasia (BPH) have been associated with side effects in man and animals. To reduce these side effects as well as suppress BPH development, the management of the condition has come to include dietary interventions. This study investigated the effect of some cooking oils on testosterone-induced hyperplasia of the prostate in rats. Male Sprague-dawley rats were distributed into eighteen groups (n=6) as A-R...
June 30, 2019: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://read.qxmd.com/read/31327752/diet-and-lifestyle-considerations-for-patients-with-prostate-cancer
#24
REVIEW
Kyle B Zuniga, June M Chan, Charles J Ryan, Stacey A Kenfield
PURPOSE: To review the literature and provide recommendations on diet and lifestyle considerations in patients with prostate cancer using evidence from randomized controlled trials (RCTs) with additional considerations based on observational evidence. MATERIALS AND METHODS: We initiated our search on ClinicalTrials.gov combining the term "prostate cancer" with a variety of diet and lifestyle factors. We then supplemented our summary of publications from registered trials by including other publications available on Pubmed...
March 2020: Urologic Oncology
https://read.qxmd.com/read/31177307/urolithin-a-induces-prostate-cancer-cell-death-in-p53-dependent-and-in-p53-independent-manner
#25
JOURNAL ARTICLE
Yasir I Mohammed Saleem, Hussam Albassam, Mustafa Selim
PURPOSE: Pomegranate and walnuts are widely consumed dietary sources and contain several bioactive compounds, including the ellagitannins (ETs). ETs are polyphenols that are metabolized in the gut microbiota to urolithin A (UA). p53 is a tumor suppressor that lost its activity through MDM2 activation in about half cancers. The purpose of this study was to investigate the influence of UA on the p53-MDM2 interaction pathway in prostate cancer cell lines. METHODS: Three human prostate cancer cell lines were used that harbor different p53 genotypes; LNCaP (p53+/+ ), 22RV1(p53-/+ ) and PC3 (p53-/- )...
June 8, 2019: European Journal of Nutrition
https://read.qxmd.com/read/30441769/experimental-evidence-of-the-antitumor-antimetastatic-and-antiangiogenic-activity-of-ellagic-acid
#26
REVIEW
Claudia Ceci, Pedro M Lacal, Lucio Tentori, Maria Gabriella De Martino, Roberto Miano, Grazia Graziani
Ellagic acid (EA) is a naturally occurring polyphenolic compound endowed with strong antioxidant and anticancer properties that is present in high quantity in a variety of berries, pomegranates, and dried fruits. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis, all processes that are crucial for tumour infiltrative behaviour and the metastatic process. In addition, EA may increase tumour sensitivity to chemotherapy and radiotherapy...
November 14, 2018: Nutrients
https://read.qxmd.com/read/30247964/an-integrative-approach-to-prostate-cancer
#27
REVIEW
Donald I Abrams
OBJECTIVES: The mostly indolent natural history and long overall survival associated with a diagnosis of prostate cancer provides a unique opportunity for men to explore diet and lifestyle interventions to alter the trajectory of their disease. As many patients may be appropriate for postponing conventional therapy, the effects of various integrative interventions can be investigated. In addition, treatment of prostate cancer with surgery, radiation, or androgen deprivation therapy, all may produce physical or psychological side effects that could be amenable to complementary therapies...
2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://read.qxmd.com/read/29737081/-the-extract-from-punica-granatum-pomegranate-leaves-promotes-apoptosis-and-impairs-metastasis-in-prostate-cancer-cells
#28
JOURNAL ARTICLE
Yuan-le Deng, Ya-Li Li, Ting-Ting Zheng, Ming-Xing Hu, Ting-Hong Ye, Yong-Mei Xie, Wen-Ya Yin
OBJECTIVE: To investigate the effects of pomegranate leaves extract(PLE)on proliferation,apoptosis and metastasis of prostate cancer cells. METHODS: The proliferation of TRAMP-C1,DU145,PC3 prostate cancer cells treated with different concentrations of PLE (final mass concentrations were 12.5,25,50,100, 200 μg/mL,respectively) for different time (24,48,72 h) was detected by MTT assay. Colony formation assay was performed to verify the long-term effects of PLE on the proliferation of DU145 and PC3 cells...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/28867799/could-pomegranate-juice-help-in-the-control-of-inflammatory-diseases
#29
REVIEW
Francesca Danesi, Lynnette R Ferguson
Fruits rich in polyphenols, such as pomegranates, have been shown to have health benefits relating to their antioxidant and anti-inflammatory properties. Using data obtained from PubMed and Scopus, this article provides a brief overview of the therapeutic effects of pomegranate on chronic inflammatory diseases (CID) such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), metabolic and cardiovascular disorders, and other inflammatory-associated conditions, with an emphasis on fruit-derived juices...
August 30, 2017: Nutrients
https://read.qxmd.com/read/28724216/the-extract-from-punica-granatum-pomegranate-peel-induces-apoptosis-and-impairs-metastasis-in-prostate-cancer-cells
#30
JOURNAL ARTICLE
Yuanle Deng, Yali Li, Fangfang Yang, Anqi Zeng, Shuping Yang, Yi Luo, Yiwen Zhang, Yongmei Xie, Tinghong Ye, Yong Xia, Wenya Yin
Prostate cancer is a big threat to male for its poor prognosis and high mortality rate. Natural compounds are important resources of many anticancer drugs. Pomegranate is a kind of antioxidant-rich fruit and its peel and seed has potential anticancer activities. In this study, we aimed to investigate the effects of pomegranate peel extract (PoPx) on the apoptosis and metastasis of prostate cancer cells and the related mechanism. We found that PoPx showed growth inhibition on prostate cancer cells. Nuclei morphological and flow cytometer (FCM) analysis indicated that PoPx could induce prostate cancer apoptosis...
September 2017: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/28709945/punicalagin-a-polyphenol-from-pomegranate-fruit-induces-growth-inhibition-and-apoptosis-in-human-pc-3-and-lncap-cells
#31
JOURNAL ARTICLE
Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien
Prostate cancer (PCa) is an international health problem and search for its effective treatment is in progress. Punicalagin (PN), polyphenol from pomegranate fruit, is known to exhibit potent anticancer activity in lung, breast and cervical cells. However, there is paucity of information on its effect in PCa. This study evaluated anti-proliferative effects of PN and its effects on extrinsic pathway of apoptosis in PCa cells, and angiogenesis in chicken chorioallantoic membrane (CAM). Antioxidant activities of PN were determined by 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation (LPO) methods...
August 25, 2017: Chemico-biological Interactions
https://read.qxmd.com/read/28440320/a-review-of-pomegranate-in-prostate-cancer
#32
REVIEW
C J Paller, A Pantuck, M A Carducci
BACKGROUND: Preclinical studies showing that pomegranate juice and its components inhibit prostate cancer led to multiple clinical trials to determine whether pomegranate products could slow the growth of prostate cancer. This review summarizes the preclinical data and discusses the results of the clinical trials. METHODS: Trials targeted patients on active surveillance, neoadjuvant patients, patients with biochemical recurrence (BCR) following local therapy for prostate cancer, and patients with metastatic castration-resistant prostate cancer (mCRPC)...
September 2017: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/28125044/pomegranate-for-prevention-and-treatment-of-cancer-an-update
#33
REVIEW
Pooja Sharma, Sarah F McClees, Farrukh Afaq
Cancer is the second leading cause of death in the United States, and those who survive cancer may experience lasting difficulties, including treatment side effects, as well as physical, cognitive, and psychosocial struggles. Naturally-occurring agents from dietary fruits and vegetables have received considerable attention for the prevention and treatment of cancers. These natural agents are safe and cost efficient in contrast to expensive chemotherapeutic agents, which may induce significant side effects. The pomegranate ( Punica granatum L...
January 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/27406859/tomato-based-randomized-controlled-trial-in-prostate-cancer-patients-effect-on-psa
#34
RANDOMIZED CONTROLLED TRIAL
Ingvild Paur, Wolfgang Lilleby, Siv Kjølsrud Bøhn, Erik Hulander, Willibrord Klein, Ljiljana Vlatkovic, Karol Axcrona, Nils Bolstad, Trine Bjøro, Petter Laake, Kristin A Taskén, Aud Svindland, Lars Magne Eri, Bjørn Brennhovd, Monica H Carlsen, Sophie D Fosså, Sigbjørn S Smeland, Anette S Karlsen, Rune Blomhoff
BACKGROUND & AIMS: The effect of lycopene-containing foods in prostate cancer development remains undetermined. We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen (PSA) in prostate cancer patients. METHODS: Prior to their curative treatment, 79 patients with prostate cancer were randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks...
June 2017: Clinical Nutrition
https://read.qxmd.com/read/27039735/anti-tumoral-properties-of-punica-granatum-pomegranate-seed-extract-in-different-human-cancer-cells
#35
JOURNAL ARTICLE
Khaled Seidi, Rana Jahanban-Esfahlan, Mozhgan Abasi, Mehran Mesgari Abbasi
BACKGROUND: Punica granatum (PG) has been demonstrated to possess antitumor effects on various types of cancer cells. In this study, we determined antiproliferative properties of a seed extract of PG (PSE) from Iran in different human cancer cells. MATERIALS AND METHODS: A methanolic extract of pomegranate seeds was prepared. Total phenolic content (TPC) and total flavonoid content (TFC) were assessed by colorimetric assays. Antioxidant activity was determined with reference to DPPH radical scavenging activity...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/26955879/clarification-of-the-molecular-pathway-of-taiwan-local-pomegranate-fruit-juice-underlying-the-inhibition-of-urinary-bladder-urothelial-carcinoma-cell-by-proteomics-strategy
#36
JOURNAL ARTICLE
Ting-Feng Wu, Li-Ting Hsu, Bo-Xian Tsang, Li-Chien Huang, Wan-Yin Shih, Li-Yi Chen
BACKGROUND: Pomegranate fruit has been shown to exhibit the inhibitory activity against prostate cancer and lung cancer in vitro and in vivo, which might be a resource for chemoprevention and chemotherapy of cancer. Our previous documented findings indicated that treatment of urinary bladder urothelial carcinoma cell with the ethanol extract isolated from the juice of pomegranate fruit grown in Taiwan could inhibit tumor cell. In this study we intended to uncover the molecular pathway underlying anti-cancer efficacy of Taiwan pomegranate fruit juice against urinary bladder urothelial carcinoma...
2016: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/26898239/phytotherapeutic-interventions-in-the-management-of-biochemically-recurrent-prostate-cancer-a-systematic-review-of-randomised-trials
#37
REVIEW
Margaret Diana van Die, Kerry M Bone, Jon Emery, Scott G Williams, Marie V Pirotta, Channing J Paller
OBJECTIVE: To evaluate the evidence from randomised trials for the efficacy and safety of phytotherapeutic interventions in the management of biochemically recurrent (BCR) prostate cancer, indicated by prostate-specific antigen (PSA) progression, numbers progressing to/time to initiation of androgen-deprivation therapy or salvage therapy. PATIENTS AND METHODS: MEDLINE (Ovid), EMBASE (Ovid), AMED (Ovid), CINAHL (EBSCO) and the Cochrane Library databases were searched...
April 2016: BJU International
https://read.qxmd.com/read/26354897/a-systematic-review-of-dietary-nutritional-and-physical-activity-interventions-for-the-prevention-of-prostate-cancer-progression-and-mortality
#38
REVIEW
Lucy E Hackshaw-McGeagh, Rachel E Perry, Verity A Leach, Sara Qandil, Mona Jeffreys, Richard M Martin, J Athene Lane
PURPOSE: Given the long-term, although potentially fatal, nature of prostate cancer, there is increasing observational evidence for the reduction in disease progression and mortality through changes in lifestyle factors. METHODS: We systematically reviewed dietary, nutritional, and physical activity randomized interventions aimed at modifying prostate cancer progression and disease-specific mortality, including a detailed assessment of risk of bias and methodological quality...
November 2015: Cancer Causes & Control: CCC
https://read.qxmd.com/read/26320438/anti-tumoral-properties-of-punica-granatum-pomegranate-peel-extract-on-different-human-cancer-cells
#39
JOURNAL ARTICLE
Sina Modaeinama, Mozhgan Abasi, Mehran Mesgari Abbasi, Rana Jahanban-Esfahlan
BACKGROUND: Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of antioxidative properties. Punica granatum (PG) (pomegranate) is a well known fruit in this context, but its cytotoxicity in cancer cells has not been extensively studied. Here, we investigated the antiproliferative properties of a peel extract of PG from Iran in different human cancer cells. MATERIALS AND METHODS: A methanolic extract of pomegranate peel (PPE) was prepared...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/26180600/potential-effects-of-pomegranate-polyphenols-in-cancer-prevention-and-therapy
#40
REVIEW
Eleonora Turrini, Lorenzo Ferruzzi, Carmela Fimognari
Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeutic potential. Pomegranate has been shown to exert anticancer activity, which is generally attributed to its high content of polyphenols. This review provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of pomegranate polyphenols as future anticancer agents...
2015: Oxidative Medicine and Cellular Longevity
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